USDMF EDMF are all available! Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the re
Cas:357336-20-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a
Cas:357336-20-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c
Cas:357336-20-0
Min.Order:1 Kilogram
FOB Price: $6.0
Type:Lab/Research institutions
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Cas:357336-20-0
Min.Order:1 Kilogram
FOB Price: $15.0 / 30.0
Type:Trading Company
inquiryProduct Name: Brivaracetam Synonyms:(alphaS,4R)-alpha-Ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide;UCB-34714;1-PyrrolidineacetaMide, α-ethyl-2-oxo-4-propyl-, (αS,4R)-;(S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanaMide;2(S)-[2-Oxo-4(R)-
Cas:357336-20-0
Min.Order:25 Gram
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Type:Trading Company
inquiryBrivaracetam[CAS:357336-20-0] 5-hydroxy-4-propylfuran-2(5H)-one[CAS:78920-10-2] L-2-Aminobutanamide hydrochloride[CAS:7682-20-4] (R)-4-propyl-dihydro-furan-2-one[CAS:63095-51-2] Chemical Name: 2(S)-[2-Oxo-4(R)-propylpyrrolidin-1-yl]b
Cas:357336-20-0
Min.Order:50 Gram
Negotiable
Type:Other
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:357336-20-0
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:357336-20-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:357336-20-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:357336-20-0
Min.Order:1 Gram
FOB Price: $6.0 / 9.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:357336-20-0
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryName: 2(S)-[2-Oxo-4(R)-propylpyrrolidin-1-yl]butyramide CAS:357336-20-0 MF: C11H20N2O2 Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:APIS Transportation:By sea or by air Port:Qingdao Port
Cas:357336-20-0
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiryAppearance:White or off- white powder Storage:ln stock Package:25kg/Barrel Application:Brain Enhancing Drug Transportation:Express/Sea/Air Port:Any port in china
Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua
Cas:357336-20-0
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:357336-20-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
Cas:357336-20-0
Min.Order:100 Kilogram
FOB Price: $1.0 / 5.0
Type:Trading Company
inquiryProduct Name: brivaracetam Synonyms: (alphaS,4R)-alpha-Ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide;UCB-34714;1-PyrrolidineacetaMide, α-ethyl-2-oxo-4-propyl-, (αS,4R)-;(S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanaMide;2(S)-[2-Oxo-4
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:357336-20-0
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryBeluga chemical professional supply Brivaracetam manufacturer of high quality 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China a
Cas:357336-20-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:357336-20-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:357336-20-0
Min.Order:1 Kilogram
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Type:Lab/Research institutions
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Cas:357336-20-0
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:357336-20-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:357336-20-0
Min.Order:1 Kilogram
FOB Price: $3.0 / 7.0
Type:Trading Company
inquiryBrivaracetam CAS 357336-20-0 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control sy
Cas:357336-20-0
Min.Order:1 Kilogram
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Type:Trading Company
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
(2S)-4,5-dehydro-(2-oxo-4-n-propyl-1-pyrrolidinyl)-2-butanamide
brivaracetam
Conditions | Yield |
---|---|
With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; copper(l) chloride; sodium t-butanolate In toluene at -40℃; for 24h; Inert atmosphere; | 99.3% |
With 5% Pd-CaCO3; hydrogen In methanol; water at -10 - 0℃; Temperature; Reagent/catalyst; Solvent; | 70.2% |
brivaracetam
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran | 93% |
With sodium hydroxide In dichloromethane at -15 - -10℃; Concentration; Reagent/catalyst; Temperature; Solvent; | 90% |
With lithium hexamethyldisilazane In tetrahydrofuran at -15 - -5℃; for 4h; | 69.8% |
(S)-2-amino-butanamide hydrochloride
brivaracetam
Conditions | Yield |
---|---|
With sodium carbonate In ethanol at 50℃; for 24h; Temperature; | 93% |
(S)-2-amino-butanamide
brivaracetam
Conditions | Yield |
---|---|
Stage #1: C7H13IO2 With 1,1'-carbonyldiimidazole In toluene at 10 - 20℃; for 0.166667h; Inert atmosphere; Stage #2: (S)-2-amino-butanamide In toluene at 10 - 20℃; | 92% |
(S)-2-amino-butanamide
brivaracetam
Conditions | Yield |
---|---|
With potassium carbonate In ethanol at 60℃; for 8h; Reagent/catalyst; Solvent; Temperature; | 91% |
With tetra-(n-butyl)ammonium iodide; sodium carbonate In Isopropyl acetate at 88.8℃; for 28h; Inert atmosphere; Cooling; | 32% |
Stage #1: (S)-2-amino-butanamide; ethyl (R)-γ-bromo-3-propylbutyrate With tetra-(n-butyl)ammonium iodide; sodium carbonate In Isopropyl acetate for 28h; Reflux; Stage #2: With acetic acid In Isopropyl acetate at 60℃; for 1.83h; | 12.66% |
brivaracetam
Conditions | Yield |
---|---|
With ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 20℃; for 2h; Time; Large scale; | 90% |
With ammonia; pivaloyl chloride; triethylamine In dichloromethane at 0 - 10℃; for 6h; Inert atmosphere; | 88% |
Stage #1: (2S)-2-[(4R)-2-oxo-4-n-propyl-1-pyrrolidinyl]butyric acid With chloroformic acid ethyl ester; triethylamine In dichloromethane at -10 - -5℃; for 1h; Stage #2: With ammonium bicarbonate In dichloromethane at -10 - -5℃; | 67% |
brivaracetam
Conditions | Yield |
---|---|
In isopropyl alcohol for 6h; Reflux; | 89.3% |
brivaracetam
Conditions | Yield |
---|---|
With ammonium hydroxide; ammonia In water at 5℃; under 750.075 - 1125.11 Torr; for 15h; | 88.7% |
(S)-2-amino-butanamide
brivaracetam
Conditions | Yield |
---|---|
With potassium hydroxide In dichloromethane at 0 - 5℃; for 2h; Molecular sieve; | 87% |
brivaracetam
Conditions | Yield |
---|---|
With ammonium hydroxide In N,N-dimethyl-formamide at 20℃; for 15h; | 86.4% |
With ammonium hydroxide; ammonia In water at 5℃; under 750.075 - 1125.11 Torr; for 15h; | 34 g |
With ammonia In tetrahydrofuran at 20℃; for 20h; | 0.91 g |
brivaracetam
Conditions | Yield |
---|---|
With triethylsilane; trifluoroacetic acid In dichloromethane at -25 - 20℃; for 4.51667h; | 81.3% |
With triethylsilane; boron trifluoride diethyl etherate In dichloromethane at 0℃; for 18h; |
brivaracetam
Conditions | Yield |
---|---|
In ethanol; n-heptane at 23 - 27℃; Product distribution / selectivity; Resolution of racemate; | 80% |
In dichloromethane Resolution of racemate; |
brivaracetam
Conditions | Yield |
---|---|
With sulfuric acid In toluene at 90 - 100℃; for 15h; Solvent; Reagent/catalyst; Temperature; Green chemistry; | 77.95% |
Multi-step reaction with 2 steps 1: thionyl chloride / tetrahydrofuran / 2 h / 0 - 20 °C 2: lithium hexamethyldisilazane / tetrahydrofuran / 4 h / -15 - -5 °C View Scheme | |
With tributylphosphine; di-tert-butyl-diazodicarboxylate In tetrahydrofuran at 20℃; for 18h; |
brivaracetam
Conditions | Yield |
---|---|
With sodium chloride In water; N,N-dimethyl-formamide at 100℃; for 16h; Solvent; Temperature; Reagent/catalyst; | 75.47% |
(S)-2-amino-butanamide
brivaracetam
Conditions | Yield |
---|---|
Stage #1: (S)-2-amino-butanamide; C7H12Br2O With tetrabutylammomium bromide; potassium hydroxide In dichloromethane at 0℃; for 10h; Stage #2: In tert-butyl methyl ether at 20℃; for 22h; Reagent/catalyst; Temperature; Inert atmosphere; | 75% |
brivaracetam
Conditions | Yield |
---|---|
With sodium hexamethyldisilazane In tetrahydrofuran at -10 - 10℃; for 1h; Reagent/catalyst; Temperature; | 75% |
With potassium tert-butylate In tetrahydrofuran at -30℃; | 69.06% |
Conditions | Yield |
---|---|
With potassium bromide In dichloromethane at 5℃; for 2.5h; Temperature; Reagent/catalyst; Inert atmosphere; | 74.8% |
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
brivaracetam
Conditions | Yield |
---|---|
Stage #1: (S)-2-aminobutyramide hydrochloride With sodium hydroxide In ethanol for 1h; Reflux; Green chemistry; Stage #2: (+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one In ethanol for 9h; Green chemistry; Stage #3: With sulfuric acid In toluene at 95 - 100℃; for 15h; Green chemistry; | 72.93% |
brivaracetam
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In isopropyl alcohol at -30 - -20℃; | 72.4% |
Conditions | Yield |
---|---|
Stage #1: (S)-2-aminobutyramide hydrochloride With potassium carbonate In Isopropyl acetate for 8h; Reflux; Stage #2: C8H15BrO2 In Isopropyl acetate for 28h; Reflux; | 68% |
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium sulfate; potassium hydroxide In dichloromethane at 20 - 30℃; for 18h; Large scale; | 64% |
With tetrabutylammomium bromide; sodium sulfate; potassium hydroxide In dichloromethane at 20 - 30℃; for 18h; Molecular sieve; | 543.5 g |
With tetrabutylammomium bromide; sodium sulfate; potassium hydroxide In dichloromethane at 20 - 30℃; for 18h; Molecular sieve; Large scale; | 543.5 g |
(S)-2-amino-butanamide
brivaracetam
Conditions | Yield |
---|---|
With sodium hydroxide In acetonitrile at 0 - 25℃; for 12h; Solvent; Reagent/catalyst; Temperature; | 64% |
Conditions | Yield |
---|---|
Stage #1: (S)-2-aminobutyramide hydrochloride With potassium carbonate In Isopropyl acetate for 8h; Reflux; Stage #2: C7H13IO2 In Isopropyl acetate for 28h; Reflux; | 63.4% |
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
(S)-2-amino-butanamide
brivaracetam
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 24h; Reflux; enantioselective reaction; | 60% |
With sodium sulfate; potassium hydroxide at 160℃; for 18h; Temperature; Molecular sieve; Inert atmosphere; | 60% |
Stage #1: (+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one; (S)-2-amino-butanamide In toluene at 20℃; for 2h; Inert atmosphere; Stage #2: With sodium tetrahydroborate; sodium hydroxide In water; toluene for 1h; Stage #3: With acetic acid In water; toluene at 50℃; for 20h; |
(S)-2-amino-butanamide
brivaracetam
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; lithium isopropylamide; sodium sulfate In N,N-dimethyl-formamide at 10 - 20℃; for 10h; Large scale; | 59% |
brivaracetam
Conditions | Yield |
---|---|
With 2-hydroxypyridin In toluene at 90℃; for 3h; Reagent/catalyst; | 58% |
With acetic acid In tetrahydrofuran at 25 - 65℃; for 4h; | 28 g |
brivaracetam
Conditions | Yield |
---|---|
With methanol; chloro-trimethyl-silane; magnesium at 20℃; for 24h; Reagent/catalyst; Temperature; | 47.6% |
A
((2R)-2-[(4R)-2-oxo-4-propyltetrahydro-1H-pyrrol-1-yl]butanamide)
B
brivaracetam
Conditions | Yield |
---|---|
Purification / work up; Resolution of diastereomeric mixture; | A 45% B 44% |
2-(2-oxo-4-propylpyrrolidin-1-yl)butanamide
brivaracetam
Conditions | Yield |
---|---|
With Chiralpak AD In ethanol; n-heptane Resolution of racemate; | 44% |
brivaracetam
Conditions | Yield |
---|---|
With benzotriazol-1-ol In toluene at 90℃; for 3h; | 40% |
With acetic acid In toluene at 80 - 85℃; for 14h; Reagent/catalyst; Temperature; Solvent; | 0.3 g |
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