DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryProduct Name: CYCLO(-GLY-PRO) Synonyms: CYCLO(-GLY-PRO);cyclo(pro-gly);Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-, (8aS)- (9CI);(8AS)-HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE;Cyclic (Pro-Gly);(S)-Hexahyd
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inquiryCYCLO(-GLY-PRO) CAS:3705-27-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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High purity, high success rate, short cycle and moderate priceAppearance:White powder solid Storage:Negative 20 degrees Celsius Package:5mg, 10mg 100mg, 1gram Application:Applied to various scientific research
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good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:10mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any por
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 200℃; under 12901.3 Torr; for 0.333333h; Microwave irradiation; | 99% |
With Zr6-based UiO-66 metal-organic frameworks at 80℃; for 24h; | 88% |
With 14C2H7N*14H(1+)*2H2O*2O(2-)*2Zr(4+)*O122P4W34(18-) In dimethyl sulfoxide at 70℃; for 24h; | 76% |
Multi-step reaction with 2 steps 1: HCl 2: 105 °C / 0 Torr View Scheme |
(2S)-N-(N-Benzyloxycarbonylglycyl)prolinamide
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol at 22℃; for 12h; | 93% |
With platinum Hydrogenation; | |
With hydrogen; palladium on activated charcoal In methanol at 22℃; |
Conditions | Yield |
---|---|
With trimethylphosphane In tetrahydrofuran; water | A 92% B n/a |
Conditions | Yield |
---|---|
With Zr6-based UiO-66 metal-organic frameworks at 80℃; for 24h; | 92% |
In phenol at 160℃; for 1h; |
t-butyloxycarbonyl-glycyl-proline methyl ester
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
In water at 130℃; for 4h; | 90% |
Multi-step reaction with 2 steps 1: formic acid 2: toluene; butan-1-ol / Heating View Scheme |
glycine ethyl ester hydrochloride
(S)-proline-N-carboxyanhydride
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
Stage #1: glycine ethyl ester hydrochloride; (S)-proline-N-carboxyanhydride With triethylamine In dichloromethane at -78℃; for 6h; Stage #2: In water for 24h; Heating; | 87% |
(9aS)-2,3,4,5,7,8,9,9a-Octahydro-1H-pyrrolo<2,1-d><1,2,5>triazepine-1,5-dione
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With ammonia; sodium In tetrahydrofuran at -60℃; for 0.25h; | 80% |
Multi-step reaction with 2 steps 1: Na, NH3 liq. / -68 °C View Scheme |
N-chloroacetyl-L-proline ethyl ester
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With ammonia In ethanol Ambient temperature; | 78.2% |
Cbz-glycyl-(L)-prolyl benzotriazole
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 18h; | 72% |
N-Nitroacetyl-(S)-proline ethyl ester
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With aluminium amalgam In ethanol at 30℃; for 8h; | 70% |
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With triethylamine In methanol Heating; | 65% |
With triethylamine In methanol for 16h; Heating / reflux; | |
With triethylamine In methanol for 16h; Heating / reflux; | |
With ammonia In methanol at 23℃; for 4h; | n/a |
H-Pro-Gly-OMe
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
at 110℃; under 0.001 Torr; | |
With triethylamine In methanol for 14h; Heating / reflux; | |
With triethylamine In methanol for 6h; Reflux; | |
With triethylamine In methanol Heating; |
H-Pro-Gly-OEt
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
at 105℃; under 0.001 Torr; | |
With ethanol; triethylamine | |
at 105℃; under 0.001 Torr; |
N-trichloroethoxycarbonylglycyl-L-proline methyl ester
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With methanol; zinc Heating; |
N-phthaloylglycine chloride
L-proline
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With hydrazine hydrate 1.) CHCl3, reflux, 4 h, 2.) CHCl3, EtOH, a) RT, 12 h, b) reflux, 24 h; Yield given. Multistep reaction; |
glycyl proline
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
(2S)-N-(N-Benzyloxycarbonylglycyl)proline methyl ester
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol at 22℃; | |
Multi-step reaction with 2 steps 1: 81 percent / NH3 / methanol / 216 h 2: 93 percent / H2 / 10percent Pd/C / methanol / 12 h / 22 °C View Scheme |
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With ethanol | |
at 105℃; under 0.001 Torr; |
H-Pro-Gly-OEt
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With phosphate buffer at 37℃; pH=7.4; Kinetics; |
Conditions | Yield |
---|---|
With dipeptidyl peptidase IV; HEPES buffer at 37℃; pH=7.4; Enzyme kinetics; |
1-(2-bromoacetyl)pyrrolidine-2-carboxylic acid methyl ester
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 57 percent / H2NNH2*H2O / ethanol / 2 h / Heating 2: 80 percent / Na, liq. NH3 / tetrahydrofuran / 0.25 h / -60 °C View Scheme | |
Multi-step reaction with 4 steps 1: H2NNH2*H2O / ethanol / Heating 2: ethanol / 1.5 h / Heating 3: Na, NH3 liq. / -68 °C View Scheme |
methyl (2S)-pyrrolidine carboxylate
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: NMM, iso-butyl chloroformate / tetrahydrofuran; dimethylformamide / -40 °C 2: H2NNH2*H2O / ethanol / Heating 3: ethanol / 1.5 h / Heating 4: Na, NH3 liq. / -68 °C View Scheme |
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethanol / 1.5 h / Heating 2: Na, NH3 liq. / -68 °C View Scheme |
N-Boc-L-proline
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 58 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, HOBT monohydrate, Et3N / 24 h / Ambient temperature 2: 100 percent / 1 h / Ambient temperature 3: 65 percent / Et3N / methanol / Heating View Scheme |
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / 1 h / Ambient temperature 2: 65 percent / Et3N / methanol / Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92.5 percent / SOCl2 2: 77.2 percent / Et3N / benzene / Ambient temperature 3: 78.2 percent / NH3 / ethanol / Ambient temperature View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / water / 20 °C 2: isobutyl chloroformate; 4-methyl-morpholine / dichloromethane / 20 °C 3: trifluoroacetic acid / dichloromethane / 20 °C 4: triethylamine / methanol / Heating View Scheme |
ethyl (2S)-pyrrolidine-2-carboxylate
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 77.2 percent / Et3N / benzene / Ambient temperature 2: 78.2 percent / NH3 / ethanol / Ambient temperature View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: palladium; acetic acid; aqueous methanol / Hydrogenation 2: HCl 3: 105 °C / 0 Torr View Scheme |
di-tert-butyl dicarbonate
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With dmap In dichloromethane at 20℃; | 92% |
prenyl bromide
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
N-dimethylallyl glycylproline diketopiperazine
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide | 84% |
trimethoxonium tetrafluoroborate
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
(8aS)-6,7,8,8a-tetrahydro-1-methoxypyrrolo[1,2-a]pyrazin-4(3H)-one
Conditions | Yield |
---|---|
In dichloromethane for 24h; Heating; | 77% |
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
(S)-octahydropyrrolo[1,2-a]pyrazine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran for 27h; Heating; | 68.9% |
With lithium aluminium tetrahydride In tetrahydrofuran for 8h; Heating; | 55% |
With lithium aluminium tetrahydride In tetrahydrofuran for 0.166667h; Heating; | |
With lithium aluminium tetrahydride In tetrahydrofuran for 3h; Reflux; | |
Multi-step reaction with 2 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / Reflux 1.2: 3 h / 0 - 20 °C 2.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C View Scheme |
1-methoxy-1H-indole-3-carbaldehyde
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
(8aS)-2-(3-formyl-1H-indol-2-yl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
Stage #1: (S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 1-methoxy-1H-indole-3-carbaldehyde In N,N-dimethyl-formamide at 0 - 20℃; for 6h; regioselective reaction; | 67% |
formaldehyd
1-naphtylpiperazine
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
In methanol; water Mannich reaction; Heating; | 59% |
In ethanol Mannich reaction; Heating; |
1-iodo-2,2-dimethyl-1,2-propadiene
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate In N,N-dimethyl-formamide at 75℃; for 16h; | 58% |
formaldehyd
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
1-(naphthalen-1-yl)-3-(R)-methylpiperazine
Conditions | Yield |
---|---|
In methanol; water Mannich reaction; Heating; | 43% |
tert-Butoxybis(dimethylamino)methane
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
(8aRS,3Z)-3-[(dimethylamino)methylidene]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 3.5h; Heating; | 43% |
formaldehyd
1-(3,4-dihydro-2H-1,5-benzodioxepin-6-yl)piperazine
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
In methanol; water Mannich reaction; Heating; | 41% |
benzyl chloroformate
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
benzyl (S)-hexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate
Conditions | Yield |
---|---|
Stage #1: (S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione With lithium aluminium tetrahydride In tetrahydrofuran for 14h; Heating / reflux; Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water at 0℃; Stage #3: benzyl chloroformate In tetrahydrofuran; water at 0 - 20℃; for 3h; | 41% |
Stage #1: (S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione With lithium aluminium tetrahydride In tetrahydrofuran for 16h; Reflux; Stage #2: benzyl chloroformate With sodium hydrogencarbonate In tetrahydrofuran at 0 - 20℃; for 3h; |
formaldehyd
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
1-(naphthalen-1-yl)-3-(S)-methylpiperazine
Conditions | Yield |
---|---|
In methanol; water Mannich reaction; Heating; | 36% |
1-iodo-propane
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
(3R,8aS)-3-Propyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With magnesium bromide; lithium diisopropyl amide In tetrahydrofuran at -70℃; for 24h; | 20% |
Conditions | Yield |
---|---|
With hydrogenchloride |
p-methoxybenzyl chloride
(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
(S)-2-(4-Methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione
Conditions | Yield |
---|---|
With sodium hydride DMF; Yield given. Multistep reaction; |
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