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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid Manufacturer/High quality/Best price/In stock

Cas:3919-74-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-(2-Chloro-6-Fluorophenyl)-5-Methylisoxazole-4-Carboxylic Acid supplier in China

Cas:3919-74-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxylic acid

Cas:3919-74-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--3919-74-2--High purity 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier

TIANFUCHEM--3919-74-2--High purity 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid factory price

Cas:3919-74-2

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Isoxazolecarboxylicacid, 3-(2-chloro-6-fluorophenyl)-5-methyl- 3919-74-2

Cas:3919-74-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid CAS:3919-74-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid CAS:3919-74-2

Cas:3919-74-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Isoxazolecarboxylicacid, 3-(2-chloro-6-fluorophenyl)-5-methyl-

Cas:3919-74-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Isoxazolecarboxylicacid, 3-(2-chloro-6-fluorophenyl)-5-methyl-

Cas:3919-74-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Price, service, company and transport advantage: 1.place of origin china with super quality by reasonable price. 2. it's customers' right to choose the package (ems, dhl, fedex, ups); 3. it's custo

BEST PRICE/3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid

Cas:3919-74-2

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid

Cas:3919-74-2

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Isoxazolecarboxylicacid, 3-(2-chloro-6-fluorophenyl)-5-methyl-

Cas:3919-74-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 3-(2-Chloro-6-Fluorophenyl)-5-Methylisoxazole-4-Carboxylic Acid

Cas:3919-74-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid

Cas:3919-74-2

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3919-74-2 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid /High quality/Best price/In stock

Cas:3919-74-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid

Cas:3919-74-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid

Cas:3919-74-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid

Cas:3919-74-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Hebei Mojin Biotechnology Co.,Ltd

We produce carbomer by our own factory,carbomer 940 is our best seller.It is used for cosmetic and medical.And we also become agent for lubrizol.Our carbomer 940 get high viscosity and good transparency.The price will depond on the market,surely supp

4-Isoxazolecarboxylicacid, 3-(2-chloro-6-fluorophenyl)-5-methyl-

Cas:3919-74-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:5g Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

3-(2-Chloro-6-fluorophenyl)-5-Methylisoxazole-4-carboxylic acid

Cas:3919-74-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid

Cas:3919-74-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

3-(2-Chloro-6-Fluorophenyl)-5-Methylisoxazole-4-Carboxylic Acid

Cas:3919-74-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Nanjing HuaNuo Bio-Pharmacuetical Co.,Ltd

Independent research and development of impurities, familiar with the market and impurity characteristics; We can ship out on the same day if the products are in stock; Focus on impurity development of new products in the market; Expert in customizi

Flucloxacillin EP Impurity D

Cas:3919-74-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white to yellow crystal powder Storage:Room temperature with sealed well Package:according to the clients requirement Applicatio

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid

Cas:3919-74-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3-(2-Chloro-6-fluorophenyl)-5-Methylisoxazole-4-carboxylic Acid

Cas:3919-74-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid

Cas:3919-74-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl)methanol
1239346-71-4

(3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl)methanol

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: (3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl)methanol With potassium permanganate; disodium hydrogenphosphate In methanol; water at 25℃; Continuous flow conditions; Sonication;
Stage #2: With hydrogenchloride; sodium thiosulfate; sodium chloride In methanol; water; ethyl acetate
87%
2-chloro-6-fluoro-N-hydroxybenzene-1-carbonimidoyl chloride
51088-25-6

2-chloro-6-fluoro-N-hydroxybenzene-1-carbonimidoyl chloride

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

Conditions
ConditionsYield
With ethanol; triethylamine at 5℃;72%
methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate
4415-09-2

methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol
With water; sodium hydroxide In methanol for 1h; pH=11 - 13; Reflux;
With water; sodium hydroxide In ethanol at 60℃; for 24h;
With sodium hydroxide In water for 3h;
2-chloro-6-fluorobenzaldehyde
387-45-1

2-chloro-6-fluorobenzaldehyde

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) NH2OH, (ii) Cl2, CHCl3, (iii) /BRN= 506727/, MeOH
2: aq. KOH / ethanol
View Scheme
Multi-step reaction with 4 steps
1.1: hydroxylamine sulfate / methanol / 0.5 h
1.2: 0.5 h / pH 8 - 9 / Reflux
2.1: chlorine / methanol / 0 - 5 °C
3.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10
3.2: 2 h / 0 - 20 °C / pH 9
4.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux
View Scheme
Multi-step reaction with 3 steps
1: sodium carbonate; hydroxylamine hydrochloride / ethanol; water / 2 h / 20 °C
2: pyridine; N-chloro-succinimide / chloroform / 1.5 h / 20 °C
3: ethanol; triethylamine / 5 °C
View Scheme
2-chloro-6-fluoro-N-hydroxybenzene-1-carbonimidoyl chloride
51088-25-6

2-chloro-6-fluoro-N-hydroxybenzene-1-carbonimidoyl chloride

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10
1.2: 2 h / 0 - 20 °C / pH 9
2.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux
View Scheme
N-[(2-chloro-6-fluorophenyl)methylidene]hydroxylamine
443-33-4

N-[(2-chloro-6-fluorophenyl)methylidene]hydroxylamine

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: chlorine / methanol / 0 - 5 °C
2.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10
2.2: 2 h / 0 - 20 °C / pH 9
3.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux
View Scheme
Multi-step reaction with 2 steps
1: pyridine; N-chloro-succinimide / chloroform / 1.5 h / 20 °C
2: ethanol; triethylamine / 5 °C
View Scheme
2-chloro-6-fluorobenzaldehyde
387-45-1

2-chloro-6-fluorobenzaldehyde

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2-chloro-6-fluorobenzaldehyde With hydroxylamine sulfate In methanol at 20 - 40℃; for 1h;
Stage #2: With chlorine; sodium carbonate; triethylamine In methanol at 0 - 20℃; for 24h; pH=~ 9.5; Inert atmosphere;
Stage #3: acetoacetic acid methyl ester With sodium carbonate In methanol pH=~ 7 - 7.5;
ethyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate
83817-51-0

ethyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol at 60℃; for 24h;

A

carbon dioxide
124-38-9

carbon dioxide

B

5,5-dimethyl-thiazolidine-2,4-dicarboxlic acid

5,5-dimethyl-thiazolidine-2,4-dicarboxlic acid

C

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

Conditions
ConditionsYield
With potassium tellurite; sulfuric acid at 14.84℃; Kinetics; Thermodynamic data; Temperature;
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride

3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride

Conditions
ConditionsYield
With phosphorus pentachloride at 45℃; for 1h;88%
With phosphorus pentachloride In toluene
With phosphorus pentachloride In toluene
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamide
4415-11-6

3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamide

Conditions
ConditionsYield
(i) SOCl2, (ii) NH3, acetone; Multistep reaction;
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / Reflux
2: sodium carbonate; ammonium hydroxide / water; diethyl ether / 3.17 h / 0 - 25 °C
View Scheme
(2-chloro-6-fluorophenyl)methanol
56456-50-9

(2-chloro-6-fluorophenyl)methanol

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

(2-chloro-6-fluoro-phenyl)methyl N-(3-(2-chloro-6-fluoro-phenyl)-5-methyl-1,2-oxazol-4-yl)carbamate
1104461-35-9

(2-chloro-6-fluoro-phenyl)methyl N-(3-(2-chloro-6-fluoro-phenyl)-5-methyl-1,2-oxazol-4-yl)carbamate

Conditions
ConditionsYield
With diphenyl phosphoryl azide; triethylamine In 1,4-dioxane Heating;
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

Prop-2-ynyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate
1391026-03-1

Prop-2-ynyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: phosphorus pentachloride / 1 h / 45 °C
2: triethylamine / dichloromethane / 2 h / 0 - 20 °C
View Scheme
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

(1-(2-morpholino-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-caroboxylate
1391026-19-9

(1-(2-morpholino-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-caroboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 1 h / 45 °C
2: triethylamine / dichloromethane / 2 h / 0 - 20 °C
3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C
View Scheme
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

(1-benzyl-1H-1,2,3-triazol-4-yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate
1391026-20-2

(1-benzyl-1H-1,2,3-triazol-4-yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 1 h / 45 °C
2: triethylamine / dichloromethane / 2 h / 0 - 20 °C
3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C
View Scheme
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

(1-(4-(1,3-dioxoisoindolin-2-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate
1391026-21-3

(1-(4-(1,3-dioxoisoindolin-2-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 1 h / 45 °C
2: triethylamine / dichloromethane / 2 h / 0 - 20 °C
3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C
View Scheme
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

(1-butyl-1H-1,2,3-triazol-4yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate
1391026-22-4

(1-butyl-1H-1,2,3-triazol-4yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 1 h / 45 °C
2: triethylamine / dichloromethane / 2 h / 0 - 20 °C
3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C
View Scheme
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

(1-allyl-1H-1,2,3-triazol-4-yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4 carboxylate
1391026-23-5

(1-allyl-1H-1,2,3-triazol-4-yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4 carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 1 h / 45 °C
2: triethylamine / dichloromethane / 2 h / 0 - 20 °C
3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C
View Scheme
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

flushloxilin triethylamine

flushloxilin triethylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 0.67 h / -5 - 0 °C
2.1: 30 - 35 °C
2.2: 1 h / -5 - 0 °C
View Scheme
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

Flucloxacillin sodium
1847-24-1

Flucloxacillin sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 0.67 h / -5 - 0 °C
2.1: 30 - 35 °C
2.2: 1 h / -5 - 0 °C
3.1: sodium isooctanoate / acetone; water; ethyl acetate / 3 h / 20 - 25 °C
View Scheme
pivaloyl chloride
3282-30-2

pivaloyl chloride

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

C16H15ClFNO4

C16H15ClFNO4

Conditions
ConditionsYield
With triethylamine In dichloromethane at -5 - 0℃; for 0.666667h; Time;
di(benzothiazol-2-yl)disulfide
120-78-5

di(benzothiazol-2-yl)disulfide

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

C18H10ClFN2O2S2

C18H10ClFN2O2S2

Conditions
ConditionsYield
With triethylamine; triethyl phosphite In dichloromethane at 5 - 15℃; Large scale;
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbothioamide

3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbothioamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / Reflux
2: sodium carbonate; ammonium hydroxide / water; diethyl ether / 3.17 h / 0 - 25 °C
3: Lawessons reagent / 1,4-dioxane / 4 h / Reflux
View Scheme
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

3-(2-chloro-6-fluorophenyl)-5-methyl-4-(thiazol-2-yl)isoxazole

3-(2-chloro-6-fluorophenyl)-5-methyl-4-(thiazol-2-yl)isoxazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / Reflux
2: sodium carbonate; ammonium hydroxide / water; diethyl ether / 3.17 h / 0 - 25 °C
3: Lawessons reagent / 1,4-dioxane / 4 h / Reflux
4: water / 24 h / Reflux
View Scheme
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

C11H9ClFN3O2

C11H9ClFN3O2

Conditions
ConditionsYield
Stage #1: 3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid With thionyl chloride for 3h; Reflux;
Stage #2: With hydrazine hydrate In 1,4-dioxane at 25℃; for 2h;
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

2-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]-5-methyl-1,3,4-oxadiazole

2-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]-5-methyl-1,3,4-oxadiazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: thionyl chloride / 3 h / Reflux
1.2: 2 h / 25 °C
2.1: 6 h / 140 °C / Microwave irradiation
View Scheme
thiazolidine-2-one
2682-49-7

thiazolidine-2-one

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

C14H10ClFN2O3S

C14H10ClFN2O3S

Conditions
ConditionsYield
Stage #1: 3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.333333h;
Stage #2: thiazolidine-2-one In dichloromethane at 20℃;
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

C19H14ClFN2O3

C19H14ClFN2O3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 40 °C
2: potassium carbonate / toluene / 0.42 h / 40 °C / Microwave irradiation
View Scheme
3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid
3919-74-2

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

C20H16ClFN2O3

C20H16ClFN2O3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 40 °C
2: potassium carbonate / toluene / 0.42 h / 40 °C / Microwave irradiation
View Scheme

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