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Triumph International Development Limilted

Appearance:Coloriess Clear liquid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao/S

2,4-Dichloro-5-(trifluoromethyl)pyrimidine Coloriess Clear liquid

Cas:3932-97-6

Min.Order:0 Metric Ton

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2,4-dichloro-5-trifluoromethylpyrimidine cas no. 3932-97-6 98%

Cas:3932-97-6

Min.Order:0

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Shangdong Shinning Pharm co.ltd

100% owned factory, regulatory compliance and be audited.Appearance:colorless liquid Application:Commercial

2,4-Dichloro-5-trifluoromethylpyrimidine Cas no.3932-97-6 99.0%+

Cas:3932-97-6

Min.Order:0

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,4-Dichloro-5-Trifluoromethylpyrimidine with high purity

Cas:3932-97-6

Min.Order:1 Kilogram

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Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Our Services 1. Certificate Of Analysis (COA) 2. Material Safety Data Sheet (MSDS) 3. Route of synthesis (ROS) 4. Method of Aanlysis (MOA)

5-Trifluoromethyl-2,4-dichloropyrimidine

Cas:3932-97-6

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,4-dichloro-5-(trifluoromethyl)pyrimidine

Cas:3932-97-6

Min.Order:1

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2,4-Dichloro-5-Trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:1 Metric Ton

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Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2,4-Dichloro-5-trifluoromethylpyrimidine Manufacturer/High quality/Best price/In stock

Cas:3932-97-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,4-Dichloro-5-(trifluoromethyl)-pyrimidine

Cas:3932-97-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2,4-Dichloro-5-trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 3932-97-6 with competitive price

Cas:3932-97-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2,4-Dichloro-5-trifluoromethylpyrimidine 3932-97-6

Cas:3932-97-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediates, 2,4-Dichloro-5-trifluoromethylpyrimidine CAS: 3932-97-6

Cas:3932-97-6

Min.Order:1 Kilogram

FOB Price: $1419.0 / 1427.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2,4-Dichloro-5-trifluoromethylpyrimidine CAS:3932-97-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high

2,4-Dichloro-5-trifluoromethylpyrimidine CAS:3932-97-6

Cas:3932-97-6

Min.Order:1 Gram

Negotiable

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2,4-Dichloro-5-trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:1 Kilogram

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2,4-Dichloro-5-trifluoromethylpyrimidine/ LIDE PHARMA- Factory supply / Best price

Cas:3932-97-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:3932-97-6

Cas:3932-97-6

Min.Order:0

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

2,4-Dichloro-5-trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,4-Dichloro-5-Trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:0

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Type:Manufacturers

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 3932-97-6 2,4-Dichloro-5-trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:1 Kilogram

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2,4-DICHLORO-5-TRIFLUOROMETHYLPYRIMIDINE

Cas:3932-97-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2,4-dichloro-5-(trifluoromethyl)pyrimidine

Cas:3932-97-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,4-Dichloro-5-trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:0

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Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2,4-Dichloro-5-trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:1 Gram

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Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2,4-Dichloro-5-Trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

CAS3932-97-6 2,4-Dichloro-5-trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:1 Kilogram

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2,4-Dichloro-5-trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:1 Kilogram

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best Offer2,4-Dichloro-5-trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:0

Negotiable

Type:Trading Company

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2,4-Dichloro-5-trifluoromethylpyrimidine

Cas:3932-97-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

2,4-Dichloro-5-trifluoromethylpyrimidine Chemical Properties Boiling point 49℃/32mm density 1.609 g/mL at 25 °C refractive index 1.4749 Fp 200 ºF storage temp. 2-8°C pka -4.89±0.29(Predicted) InChIKey VAB

2,4-Dichloro-5-(trifluoromethyl)pyrimidine

Cas:3932-97-6

Min.Order:1 Gram

FOB Price: $65.0

Type:Lab/Research institutions

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Synthetic route

5-trifluoromethyluracil
54-20-6

5-trifluoromethyluracil

2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

Conditions
ConditionsYield
With phosphoric acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate at 85 - 100℃; for 20h;95%
With phosphoric acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate In water at 85 - 100℃; for 20.25h;95%
With N-ethyl-N,N-diisopropylamine; trichlorophosphate; phosphoric acid at 85 - 100℃; for 20.25h;95%
trifluoromethyluracil

trifluoromethyluracil

2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

Conditions
ConditionsYield
With phosphoric acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate at 85 - 100℃; for 20h;95%
(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

2,4-dichloro-5-iodopyrimidine
13544-44-0

2,4-dichloro-5-iodopyrimidine

2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

Conditions
ConditionsYield
With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; Trimethyl borate In dimethyl sulfoxide at 60℃; for 2h; Inert atmosphere;81%
2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine
170911-92-9

4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine

tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate
1393900-79-2

tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 0.833333h;
Stage #2: 4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine With triethylamine In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0 - 20℃; for 18h;
98%
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 0.5h;
Stage #2: 4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine With triethylamine In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0 - 20℃; for 18h;
98%
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc dibromide In 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 0.5h;
Stage #2: 4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine With triethylamine In 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 3h;
72.3%
tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate
170011-57-1

tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate

2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate
1383682-52-7

tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In cis-1,2-Dichloroethylene; diethyl ether; butan-1-ol at 20℃; for 0.166667h;
Stage #2: tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate With triethylamine In cis-1,2-Dichloroethylene; diethyl ether; butan-1-ol at 20℃;
98%
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 20℃; for 0.166667h;
Stage #2: tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate With triethylamine In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 20℃;
98%
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 1h; Inert atmosphere;
Stage #2: tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate With triethylamine In 1,2-dichloro-ethane; tert-butyl alcohol at 0 - 20℃; for 24.5h;
88%
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 1h; Inert atmosphere;
Stage #2: tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate With triethylamine In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0 - 20℃; for 24.5h;
88%
2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

tert-butyl (4-aminobenzyl)carbamate
94838-55-8

tert-butyl (4-aminobenzyl)carbamate

tert-butyl 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzylcarbamate
1073160-22-1

tert-butyl 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzylcarbamate

Conditions
ConditionsYield
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 20℃; for 0.333333h;
Stage #2: tert-butyl (4-aminobenzyl)carbamate With triethylamine at 20℃;
97%
4-[(tert-butyldimethylsilyl)oxy]aniline
111359-74-1

4-[(tert-butyldimethylsilyl)oxy]aniline

2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

N-(4-((tert-butyldimethylsilyl)oxy)phenyl)-4-chloro-5-(trifluoromethyl)pyrimidin-2-amine

N-(4-((tert-butyldimethylsilyl)oxy)phenyl)-4-chloro-5-(trifluoromethyl)pyrimidin-2-amine

Conditions
ConditionsYield
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc dibromide In 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 0.5h;
Stage #2: 4-[(tert-butyldimethylsilyl)oxy]aniline With triethylamine In 1,2-dichloro-ethane; tert-butyl alcohol at 0 - 20℃; for 20h;
97%
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc dibromide In 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 0.5h;
Stage #2: 4-[(tert-butyldimethylsilyl)oxy]aniline With triethylamine In 1,2-dichloro-ethane; tert-butyl alcohol at 0 - 20℃; for 20h;
97%
4-nitro-phenol
100-02-7

4-nitro-phenol

2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

4-chloro-2-(4-nitrophenoxyl)-5-trifluoromethyl pyrimidine
1265228-21-4

4-chloro-2-(4-nitrophenoxyl)-5-trifluoromethyl pyrimidine

Conditions
ConditionsYield
With 4-methyl-morpholine In isopropyl alcohol at -5 - 20℃; for 4h;96%
With 4-methyl-morpholine In isopropyl alcohol at -5 - 20℃;90%
In 1-methyl-pyrrolidin-2-one; isopropyl alcohol at -5 - 20℃; for 4h; Product distribution / selectivity;90%
With N-(2-(4-tert-butyl-piperazin-1-yl)-4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide In isopropyl alcohol for 1h; Cooling with ice;
2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

phenol
108-95-2

phenol

2-chloro-4-phenoxy-5-(trifluoromethyl)pyrimidine

2-chloro-4-phenoxy-5-(trifluoromethyl)pyrimidine

Conditions
ConditionsYield
With potassium carbonate In acetone at 0℃; for 1h;96%
2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

sodium thiomethoxide
5188-07-8

sodium thiomethoxide

4-chloro-2-methylsulfany l-5-(trifluoromethyl)pyrimidine
919116-36-2

4-chloro-2-methylsulfany l-5-(trifluoromethyl)pyrimidine

Conditions
ConditionsYield
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether at 0℃; for 2h;
Stage #2: sodium thiomethoxide In diethyl ether at 0 - 20℃; for 48h;
95%
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether at 0℃; for 2h;
Stage #2: sodium thiomethoxide In diethyl ether at 0 - 20℃; for 48h;
95%
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether at 0℃; for 2h;
Stage #2: sodium thiomethoxide In diethyl ether at 0 - 25℃; for 48h;
95%
4-chloro-aniline
106-47-8

4-chloro-aniline

2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

A

(4-chlorophenyl)-(4-chloro-5-trifluoromethyl-pyrimidin-2-yl)-amine
514842-83-2

(4-chlorophenyl)-(4-chloro-5-trifluoromethyl-pyrimidin-2-yl)-amine

B

C11H6Cl2F3N3
1448795-01-4

C11H6Cl2F3N3

Conditions
ConditionsYield
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0℃;
Stage #2: 4-chloro-aniline With triethylamine In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 20℃;
A 95%
B n/a
2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

2,4-bis(2,2,2-trifluoroethoxy)-5-(trifluoromethyl)pyrimidine

2,4-bis(2,2,2-trifluoroethoxy)-5-(trifluoromethyl)pyrimidine

Conditions
ConditionsYield
Stage #1: 2,2,2-trifluoroethanol With n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.5h; Inert atmosphere;
Stage #2: 2,4-dichloro-5-trifluoromethylpyrimidine In tetrahydrofuran; hexane at -20 - 40℃; for 24.5h; Inert atmosphere;
91%
Stage #1: 2,2,2-trifluoroethanol With n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.5h; Inert atmosphere;
Stage #2: 2,4-dichloro-5-trifluoromethylpyrimidine In tetrahydrofuran; hexane at -20 - 40℃; for 24.5h; Inert atmosphere;
91%
Stage #1: 2,2,2-trifluoroethanol With n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.5h; Inert atmosphere;
Stage #2: 2,4-dichloro-5-trifluoromethylpyrimidine In tetrahydrofuran; hexane at 40℃; for 24h;
91%
2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

5-trifluoromethyluracil
54-20-6

5-trifluoromethyluracil

Conditions
ConditionsYield
With acetic acid In water at 110℃; for 5h;90.6%
2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline
304897-49-2

4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline

tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate
1393901-46-6

tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 1h;
Stage #2: 4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline With triethylamine In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 20℃; Cooling with ice;
90%
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 1h; Inert atmosphere;
Stage #2: 4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline With triethylamine In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0 - 20℃;
90%
3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester
875798-79-1

3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester

2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate
1393900-90-7

tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 0.5h;
Stage #2: 3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0 - 20℃; for 60h;
90%
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 0.5h;
Stage #2: 3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester With triethylamine In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0 - 20℃; for 60h;
90%
tert-butyl 4-(4-amino-2-methylphenyl)-piperidine-1-carboxylate
955369-50-3

tert-butyl 4-(4-amino-2-methylphenyl)-piperidine-1-carboxylate

2,4-dichloro-5-trifluoromethylpyrimidine
3932-97-6

2,4-dichloro-5-trifluoromethylpyrimidine

tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidine-2-yl)amino)-2-methylphenyl)piperidine-1-carboxylate
1383682-55-0

tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidine-2-yl)amino)-2-methylphenyl)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 2,4-dichloro-5-trifluoromethylpyrimidine With zinc(II) chloride In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol at 0℃; for 1h; Inert atmosphere;
Stage #2: tert-butyl 4-(4-amino-2-methylphenyl)-piperidine-1-carboxylate With triethylamine In 1,2-dichloro-ethane; tert-butyl alcohol at 0 - 20℃; for 16.5h;
89%

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