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inquirygood quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran
Conditions | Yield |
---|---|
With potassium fluoride; C114H158O4P2Pd2; silver fluoride In tert-butyl methyl ether at 110℃; for 14h; Sealed tube; | 90% |
Stage #1: 4-bromoisoquinoline With n-butyllithium In tetrahydrofuran at -65℃; for 0.5h; Stage #2: With N-fluorobis(benzenesulfon)imide In tetrahydrofuran at -65℃; for 2h; | 60% |
Stage #1: 4-bromoisoquinoline With n-butyllithium In tetrahydrofuran; hexane at -65℃; for 1.5h; Cooling with acetone-dry ice; Stage #2: With N-fluorobis(benzenesulfon)imide In tetrahydrofuran; hexane at -65℃; for 1h; | |
Stage #1: 4-bromoisoquinoline With n-butyllithium In tetrahydrofuran; hexane at -65℃; for 1.5h; Stage #2: With N-fluorobis(benzenesulfon)imide In tetrahydrofuran; hexane at -65℃; for 2h; Stage #3: With sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 12h; | |
Stage #1: 4-bromoisoquinoline With n-butyllithium In tetrahydrofuran; hexane at -65℃; for 1.5h; Stage #2: With N-fluorobis(benzenesulfon)imide In tetrahydrofuran; hexane at -65 - 20℃; |
4-aminoisoquinoline
4-fluoroisoquinoline
Conditions | Yield |
---|---|
Stage #1: 4-aminoisoquinoline With lithium tetrafluoroborate; tert.-butylnitrite; trifluoroacetic acid In ethyl acetate at 60℃; Balz-Schiemann Reaction; Flow reactor; Stage #2: With lithium tetrafluoroborate In ethyl acetate Flow reactor; | 74% |
Stage #1: 4-aminoisoquinoline With tetrafluoroboric acid; sodium nitrite In water at -10 - -8℃; for 1h; Stage #2: In toluene at 90℃; for 1h; | 8% |
4-fluoroisoquinoline
4-bromoisoquinoline
N-fluorobis(benzenesulfon)imide
4-fluoroisoquinoline
Conditions | Yield |
---|---|
Stage #1: 4-bromoisoquinoline With n-butyllithium In tetrahydrofuran at -65℃; for 0.5h; Stage #2: N-fluorobis(benzenesulfon)imide In tetrahydrofuran at -65 - 25℃; for 11.5h; Inert atmosphere; |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: Selectfluor / acetonitrile / 2.5 h / 20 °C / Inert atmosphere 2.1: trichlorophosphate / dichloromethane / 20 - 47 °C 2.2: 2 h / 65 - 67 °C 3.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr View Scheme | |
Multi-step reaction with 3 steps 1: Selectfluor / acetonitrile / 2.5 h / 20 °C / Inert atmosphere 2: trichlorophosphate / dichloromethane / 20 - 47 °C 3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr View Scheme | |
Multi-step reaction with 4 steps 1: Selectfluor / acetonitrile / 2.5 h / 20 °C / Inert atmosphere 2: trichlorophosphate / dichloromethane / 20 - 47 °C 3: trichlorophosphate / 2.5 h / 66 - 68 °C 4: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr View Scheme | |
Multi-step reaction with 4 steps 1: Selectfluor / acetonitrile / 2.5 h / 20 °C / Inert atmosphere 2: hydrogenchloride / dichloromethane; ethyl acetate / 6 h / 20 °C 3: trichlorophosphate / 2.5 h / 66 - 68 °C 4: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trichlorophosphate / dichloromethane / 20 - 47 °C 2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr View Scheme | |
Multi-step reaction with 3 steps 1: trichlorophosphate / dichloromethane / 20 - 47 °C 2: trichlorophosphate / 2.5 h / 66 - 68 °C 3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / dichloromethane; ethyl acetate / 6 h / 20 °C 2: trichlorophosphate / 2.5 h / 66 - 68 °C 3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trichlorophosphate / 2.5 h / 66 - 68 °C 2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr View Scheme |
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 760.051 Torr; Reagent/catalyst; Overall yield = 33 mg; |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Selectfluor / acetonitrile; methanol / 3 h / Reflux 2: hydrogenchloride / water; ethyl acetate 3: trichlorophosphate / 3 h / Reflux 4: palladium on activated charcoal; sodium hydroxide; hydrogen / methanol; water / 3 h / 20 °C View Scheme |
4-fluoroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / water; ethyl acetate 2: trichlorophosphate / 3 h / Reflux 3: palladium on activated charcoal; sodium hydroxide; hydrogen / methanol; water / 3 h / 20 °C View Scheme |
4-fluoroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trichlorophosphate / 3 h / Reflux 2: palladium on activated charcoal; sodium hydroxide; hydrogen / methanol; water / 3 h / 20 °C View Scheme |
4-fluoroisoquinoline
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen; sodium hydroxide In methanol; water at 20℃; for 3h; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-fluorobis(benzenesulfon)imide / acetonitrile / 6 h / 60 °C 2: hydrogen / water; methanol / 6 h / 20 °C / Flow reactor; Alkaline conditions View Scheme |
1-bromo-4-fluoroisoquinoline
4-fluoroisoquinoline
Conditions | Yield |
---|---|
With hydrogen In methanol; water at 20℃; for 6h; Temperature; Flow reactor; Alkaline conditions; |
4-fluoroisoquinoline
4-fluoroisoquinoline sulfate
Conditions | Yield |
---|---|
With sulfuric acid In acetone at 0 - 10℃; for 2h; Inert atmosphere; Large scale reaction; | 99% |
With sulfuric acid In acetone at 0 - 10℃; for 2h; | 98.8% |
With sulfuric acid In acetone at -5℃; for 2h; Temperature; |
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 14h; | 88% |
4-fluoroisoquinoline
1-phenylcyclopropan-1-ol
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate In water; dimethyl sulfoxide at 70℃; for 12h; Inert atmosphere; | 68% |
Conditions | Yield |
---|---|
With C24H42N3(1+)*ClO4(1-); lithium perchlorate; acetic acid; trifluoroacetic acid In acetonitrile at 20℃; for 36h; Irradiation; Electrochemical reaction; Inert atmosphere; regioselective reaction; | 61% |
4-fluoroisoquinoline
A
C9H5ClFNO2S*ClH
B
4-fluoroisoquinoline-5-sulfonyl chloride hydrochloride
Conditions | Yield |
---|---|
Stage #1: 4-fluoroisoquinoline With sulfuric acid at 10 - 40℃; for 0.5h; Stage #2: With sulfur trioxide at 20 - 45℃; for 12h; Stage #3: With hydrogenchloride; thionyl chloride; sodium hydrogencarbonate Product distribution / selectivity; more than 3 stages; | A n/a B 55% |
With chlorosulfonic acid Inert atmosphere; | A 24 %Chromat. B 13 %Chromat. |
Multi-step reaction with 2 steps 1.1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction 2.1: sulfur trioxide / ethyl acetate / 19 h / 30 °C / Inert atmosphere; Large scale reaction 2.2: 7 h / 30 - 70 °C / Inert atmosphere 2.3: 1 h / 35 °C / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
With tert-butyl peroxyacetate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; trifluoroacetic acid In acetonitrile at 20℃; for 24h; Inert atmosphere; Sealed tube; Irradiation; | 49% |
4-fluoroisoquinoline
Conditions | Yield |
---|---|
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 2.9-dimethyl-1,10-phenanthroline; zinc trifluoromethanesulfonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In N,N-dimethyl acetamide for 24h; Inert atmosphere; Irradiation; | 18% |
4-fluoroisoquinoline
4-fluoro-5-nitroisoquinoline
Conditions | Yield |
---|---|
Stage #1: 4-fluoroisoquinoline With sulfuric acid; potassium nitrate at -5 - 5℃; for 1h; Stage #2: With ammonia In water pH=8; | |
With sulfuric acid; potassium nitrate In water at -5 - 0℃; for 1h; | |
Stage #1: 4-fluoroisoquinoline With sulfuric acid; potassium nitrate at -5 - 5℃; Stage #2: With ammonia In water pH=8; Cooling with ice; | |
With sulfuric acid; nitric acid at 0 - 20℃; for 3h; | 23 g |
With sulfuric acid; potassium nitrate at 25℃; for 12h; Inert atmosphere; | 5 g |
4-fluoroisoquinoline
(S)-(-)-4-fluoro-N-(1-hydroxypropan-2-yl)isoquinoline-5-sulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction 2.1: sulfur trioxide / ethyl acetate / 19 h / 30 °C / Inert atmosphere; Large scale reaction 2.2: 7 h / 30 - 70 °C / Inert atmosphere 2.3: 1 h / 35 °C / Inert atmosphere 3.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction View Scheme | |
Multi-step reaction with 2 steps 1: chlorosulfonic acid / Inert atmosphere 2: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction 2.1: sulfur trioxide / ethyl acetate / 19 h / 30 °C / Inert atmosphere; Large scale reaction 2.2: 7 h / 30 - 70 °C / Inert atmosphere 2.3: 1 h / 35 °C / Inert atmosphere 3.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction 4.1: triethylamine / tetrahydrofuran / -10 - 0 °C / Inert atmosphere; Large scale reaction View Scheme | |
Multi-step reaction with 3 steps 1: chlorosulfonic acid / Inert atmosphere 2: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction 3: triethylamine / tetrahydrofuran / -10 - 0 °C / Inert atmosphere; Large scale reaction View Scheme |
4-fluoroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction 2.1: sulfur trioxide / ethyl acetate / 19 h / 30 °C / Inert atmosphere; Large scale reaction 2.2: 7 h / 30 - 70 °C / Inert atmosphere 2.3: 1 h / 35 °C / Inert atmosphere 3.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction 4.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 20 h / -10 - 0 °C / Inert atmosphere; Large scale reaction 4.2: 0 - 25 °C / Inert atmosphere; Large scale reaction 4.3: 0.58 h / 75 °C / Inert atmosphere; Large scale reaction View Scheme | |
Multi-step reaction with 3 steps 1.1: chlorosulfonic acid / Inert atmosphere 2.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction 3.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 20 h / -10 - 0 °C / Inert atmosphere; Large scale reaction 3.2: 0 - 25 °C / Inert atmosphere; Large scale reaction 3.3: 0.58 h / 75 °C / Inert atmosphere; Large scale reaction View Scheme |
4-fluoroisoquinoline
4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction 2.1: sulfur trioxide / ethyl acetate / 19 h / 30 °C / Inert atmosphere; Large scale reaction 2.2: 7 h / 30 - 70 °C / Inert atmosphere 2.3: 1 h / 35 °C / Inert atmosphere 3.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction 4.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 20 h / -10 - 0 °C / Inert atmosphere; Large scale reaction 4.2: 0 - 25 °C / Inert atmosphere; Large scale reaction 4.3: 0.58 h / 75 °C / Inert atmosphere; Large scale reaction 5.1: potassium carbonate / dichloromethane; water / 1 h / 20 °C / Inert atmosphere; Large scale reaction 5.2: 0.5 h / 25 °C / Inert atmosphere; Large scale reaction 5.3: 5 - 15 °C / Inert atmosphere; Large scale reaction View Scheme | |
Multi-step reaction with 4 steps 1.1: chlorosulfonic acid / Inert atmosphere 2.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction 3.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 20 h / -10 - 0 °C / Inert atmosphere; Large scale reaction 3.2: 0 - 25 °C / Inert atmosphere; Large scale reaction 3.3: 0.58 h / 75 °C / Inert atmosphere; Large scale reaction 4.1: potassium carbonate / dichloromethane; water / 1 h / 20 °C / Inert atmosphere; Large scale reaction 4.2: 0.5 h / 25 °C / Inert atmosphere; Large scale reaction 4.3: 5 - 15 °C / Inert atmosphere; Large scale reaction View Scheme |
4-fluoroisoquinoline
A
4-fluoroisoquinoline-5-sulfonic acid
B
4-fluoroisoquinoline-8-sulfonic acid
Conditions | Yield |
---|---|
With sulfuric acid; sulfur trioxide at 30℃; for 4h; Inert atmosphere; | |
Multi-step reaction with 2 steps 1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction 2: sulfur trioxide / 19 h / 30 °C / Inert atmosphere View Scheme | |
With phosphotungstic acid; sulfuric acid; sulfur trioxide at 30℃; for 3h; Reagent/catalyst; Temperature; |
4-fluoroisoquinoline
4-fluoro-5-isoquinolinesulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sulfuric acid; potassium nitrate / 12 h / 25 °C / Inert atmosphere 2.1: zinc; ammonium chloride / water; tetrahydrofuran / 5 h / 25 °C / Inert atmosphere 3.1: hydrogenchloride; sodium nitrate / water / 1 h / -15 °C / Inert atmosphere 3.2: 2 h / -5 - 0 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction 2.1: sulfur trioxide / 19 h / 30 °C / Inert atmosphere; Large scale reaction 2.2: 7 h / 30 - 70 °C / Inert atmosphere View Scheme |
4-fluoroisoquinoline
1-bromo-4-fluoroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 14 h / 0 - 20 °C 2.1: tetrabutylammomium bromide / dichloromethane / 0.17 h / 20 °C / Inert atmosphere; Molecular sieve 2.2: 20 °C / Inert atmosphere View Scheme |
4-fluoroisoquinoline
4-fluoroisoquinoline-5-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuric acid; potassium nitrate / 12 h / 25 °C / Inert atmosphere 2: zinc; ammonium chloride / water; tetrahydrofuran / 5 h / 25 °C / Inert atmosphere View Scheme |
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