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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

4-FLUOROISOQUINOLINE

Cas:394-67-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

4-Fluoroisoquinoline 394-67-2

Cas:394-67-2

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

4-Fluoroisoquinoline 394-67-2

Cas:394-67-2

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Discount price CAS 394-67-2 with best quality

Cas:394-67-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Fluoroisoquinoline 394-67-2

Cas:394-67-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Syntheses Material Intermediate, 4-Fluoroisoquinoline CAS:394-67-2

Cas:394-67-2

Min.Order:1 Kilogram

FOB Price: $272.0 / 298.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

4-Fluoroisoquinoline CAS:394-67-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inter

4-Fluoroisoquinoline CAS:394-67-2

Cas:394-67-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

4-Fluoroisoquinoline/ LIDE PHARMA- Factory supply / Best price

Cas:394-67-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/ 4-Fluoroisoquinoline /Manufacturer in China

Cas:394-67-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Fluoroisoquinoline cas no. 394-67-2 98%

Cas:394-67-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Greenutra Resource Inc

4-FluoroisoquinolineAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

4-Fluoroisoquinoline CAS No.394-67-2

Cas:394-67-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

4-Fluoroisoquinoline

Cas:394-67-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-bromoisoquinoline
1532-97-4

4-bromoisoquinoline

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
With potassium fluoride; C114H158O4P2Pd2; silver fluoride In tert-butyl methyl ether at 110℃; for 14h; Sealed tube;90%
Stage #1: 4-bromoisoquinoline With n-butyllithium In tetrahydrofuran at -65℃; for 0.5h;
Stage #2: With N-fluorobis(benzenesulfon)imide In tetrahydrofuran at -65℃; for 2h;
60%
Stage #1: 4-bromoisoquinoline With n-butyllithium In tetrahydrofuran; hexane at -65℃; for 1.5h; Cooling with acetone-dry ice;
Stage #2: With N-fluorobis(benzenesulfon)imide In tetrahydrofuran; hexane at -65℃; for 1h;
Stage #1: 4-bromoisoquinoline With n-butyllithium In tetrahydrofuran; hexane at -65℃; for 1.5h;
Stage #2: With N-fluorobis(benzenesulfon)imide In tetrahydrofuran; hexane at -65℃; for 2h;
Stage #3: With sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 12h;
Stage #1: 4-bromoisoquinoline With n-butyllithium In tetrahydrofuran; hexane at -65℃; for 1.5h;
Stage #2: With N-fluorobis(benzenesulfon)imide In tetrahydrofuran; hexane at -65 - 20℃;
4-aminoisoquinoline
23687-25-4

4-aminoisoquinoline

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
Stage #1: 4-aminoisoquinoline With lithium tetrafluoroborate; tert.-butylnitrite; trifluoroacetic acid In ethyl acetate at 60℃; Balz-Schiemann Reaction; Flow reactor;
Stage #2: With lithium tetrafluoroborate In ethyl acetate Flow reactor;
74%
Stage #1: 4-aminoisoquinoline With tetrafluoroboric acid; sodium nitrite In water at -10 - -8℃; for 1h;
Stage #2: In toluene at 90℃; for 1h;
8%
isoquinoline-4-diazonium-tetrafluoroborate

isoquinoline-4-diazonium-tetrafluoroborate

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

4-bromoisoquinoline
1532-97-4

4-bromoisoquinoline

N-fluorobis(benzenesulfon)imide
133745-75-2

N-fluorobis(benzenesulfon)imide

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
Stage #1: 4-bromoisoquinoline With n-butyllithium In tetrahydrofuran at -65℃; for 0.5h;
Stage #2: N-fluorobis(benzenesulfon)imide In tetrahydrofuran at -65 - 25℃; for 11.5h; Inert atmosphere;
1-isoquinolone
491-30-5

1-isoquinolone

A

isoquinoline
119-65-3

isoquinoline

B

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: Selectfluor / acetonitrile / 2.5 h / 20 °C / Inert atmosphere
2.1: trichlorophosphate / dichloromethane / 20 - 47 °C
2.2: 2 h / 65 - 67 °C
3.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 3 steps
1: Selectfluor / acetonitrile / 2.5 h / 20 °C / Inert atmosphere
2: trichlorophosphate / dichloromethane / 20 - 47 °C
3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 4 steps
1: Selectfluor / acetonitrile / 2.5 h / 20 °C / Inert atmosphere
2: trichlorophosphate / dichloromethane / 20 - 47 °C
3: trichlorophosphate / 2.5 h / 66 - 68 °C
4: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 4 steps
1: Selectfluor / acetonitrile / 2.5 h / 20 °C / Inert atmosphere
2: hydrogenchloride / dichloromethane; ethyl acetate / 6 h / 20 °C
3: trichlorophosphate / 2.5 h / 66 - 68 °C
4: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr
View Scheme
C10H10FNO2

C10H10FNO2

A

isoquinoline
119-65-3

isoquinoline

B

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trichlorophosphate / dichloromethane / 20 - 47 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 3 steps
1: trichlorophosphate / dichloromethane / 20 - 47 °C
2: trichlorophosphate / 2.5 h / 66 - 68 °C
3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / dichloromethane; ethyl acetate / 6 h / 20 °C
2: trichlorophosphate / 2.5 h / 66 - 68 °C
3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr
View Scheme
4-fluoroisoquinolin-1(2H)-one

4-fluoroisoquinolin-1(2H)-one

A

isoquinoline
119-65-3

isoquinoline

B

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trichlorophosphate / 2.5 h / 66 - 68 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr
View Scheme
1-chloro-4-fluoroisoquinoline

1-chloro-4-fluoroisoquinoline

A

isoquinoline
119-65-3

isoquinoline

B

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 760.051 Torr; Reagent/catalyst; Overall yield = 33 mg;
1-hydroxyisoquinoline
491-30-5

1-hydroxyisoquinoline

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Selectfluor / acetonitrile; methanol / 3 h / Reflux
2: hydrogenchloride / water; ethyl acetate
3: trichlorophosphate / 3 h / Reflux
4: palladium on activated charcoal; sodium hydroxide; hydrogen / methanol; water / 3 h / 20 °C
View Scheme
4-fluoro-3-methoxyisoquinolin-1-ol

4-fluoro-3-methoxyisoquinolin-1-ol

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water; ethyl acetate
2: trichlorophosphate / 3 h / Reflux
3: palladium on activated charcoal; sodium hydroxide; hydrogen / methanol; water / 3 h / 20 °C
View Scheme
4-fluoroisoquinolin-1-ol

4-fluoroisoquinolin-1-ol

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trichlorophosphate / 3 h / Reflux
2: palladium on activated charcoal; sodium hydroxide; hydrogen / methanol; water / 3 h / 20 °C
View Scheme
1-chloro-4-fluoroisoquinoline

1-chloro-4-fluoroisoquinoline

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen; sodium hydroxide In methanol; water at 20℃; for 3h;
1-bromoisoquinoline
1532-71-4

1-bromoisoquinoline

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-fluorobis(benzenesulfon)imide / acetonitrile / 6 h / 60 °C
2: hydrogen / water; methanol / 6 h / 20 °C / Flow reactor; Alkaline conditions
View Scheme
1-­bromo-4-fluoroisoquinoline
1421517-86-3

1-­bromo-4-fluoroisoquinoline

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

Conditions
ConditionsYield
With hydrogen In methanol; water at 20℃; for 6h; Temperature; Flow reactor; Alkaline conditions;
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

4-fluoroisoquinoline sulfate
906820-09-5

4-fluoroisoquinoline sulfate

Conditions
ConditionsYield
With sulfuric acid In acetone at 0 - 10℃; for 2h; Inert atmosphere; Large scale reaction;99%
With sulfuric acid In acetone at 0 - 10℃; for 2h;98.8%
With sulfuric acid In acetone at -5℃; for 2h; Temperature;
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

4­-fluoroisoquinoline N­-oxide
1008-32-8

4­-fluoroisoquinoline N­-oxide

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 14h;88%
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

1-phenylcyclopropan-1-ol
29526-96-3

1-phenylcyclopropan-1-ol

3-(4-fluoroisoquinolin-1-yl)-1-phenylpropan-1-one

3-(4-fluoroisoquinolin-1-yl)-1-phenylpropan-1-one

Conditions
ConditionsYield
With dipotassium peroxodisulfate In water; dimethyl sulfoxide at 70℃; for 12h; Inert atmosphere;68%
2-methyltetrahydrofuran
96-47-9

2-methyltetrahydrofuran

4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

4-fluoro-1-(5-methyltetrahydrofuran-2-yl)isoquinoline

4-fluoro-1-(5-methyltetrahydrofuran-2-yl)isoquinoline

Conditions
ConditionsYield
With C24H42N3(1+)*ClO4(1-); lithium perchlorate; acetic acid; trifluoroacetic acid In acetonitrile at 20℃; for 36h; Irradiation; Electrochemical reaction; Inert atmosphere; regioselective reaction;61%
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

A

C9H5ClFNO2S*ClH
1334294-10-8

C9H5ClFNO2S*ClH

B

4-fluoroisoquinoline-5-sulfonyl chloride hydrochloride
906820-08-4

4-fluoroisoquinoline-5-sulfonyl chloride hydrochloride

Conditions
ConditionsYield
Stage #1: 4-­fluoroisoquinoline With sulfuric acid at 10 - 40℃; for 0.5h;
Stage #2: With sulfur trioxide at 20 - 45℃; for 12h;
Stage #3: With hydrogenchloride; thionyl chloride; sodium hydrogencarbonate Product distribution / selectivity; more than 3 stages;
A n/a
B 55%
With chlorosulfonic acid Inert atmosphere;A 24 %Chromat.
B 13 %Chromat.
Multi-step reaction with 2 steps
1.1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction
2.1: sulfur trioxide / ethyl acetate / 19 h / 30 °C / Inert atmosphere; Large scale reaction
2.2: 7 h / 30 - 70 °C / Inert atmosphere
2.3: 1 h / 35 °C / Inert atmosphere
View Scheme
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

1-iodocyclohexane
626-62-0

1-iodocyclohexane

1-cyclohexyl-4-fluoroisoquinoline

1-cyclohexyl-4-fluoroisoquinoline

Conditions
ConditionsYield
With tert-butyl peroxyacetate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; trifluoroacetic acid In acetonitrile at 20℃; for 24h; Inert atmosphere; Sealed tube; Irradiation;49%
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate

1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate

1-cyclohexyl-4-fluoroisoquinoline

1-cyclohexyl-4-fluoroisoquinoline

Conditions
ConditionsYield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 2.9-dimethyl-1,10-phenanthroline; zinc trifluoromethanesulfonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In N,N-dimethyl acetamide for 24h; Inert atmosphere; Irradiation;18%
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

4-fluoro-5-nitroisoquinoline
928664-13-5

4-fluoro-5-nitroisoquinoline

Conditions
ConditionsYield
Stage #1: 4-­fluoroisoquinoline With sulfuric acid; potassium nitrate at -5 - 5℃; for 1h;
Stage #2: With ammonia In water pH=8;
With sulfuric acid; potassium nitrate In water at -5 - 0℃; for 1h;
Stage #1: 4-­fluoroisoquinoline With sulfuric acid; potassium nitrate at -5 - 5℃;
Stage #2: With ammonia In water pH=8; Cooling with ice;
With sulfuric acid; nitric acid at 0 - 20℃; for 3h;23 g
With sulfuric acid; potassium nitrate at 25℃; for 12h; Inert atmosphere;5 g
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

(S)-(-)-4-fluoro-N-(1-hydroxypropan-2-yl)isoquinoline-5-sulfonamide
223644-12-0

(S)-(-)-4-fluoro-N-(1-hydroxypropan-2-yl)isoquinoline-5-sulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction
2.1: sulfur trioxide / ethyl acetate / 19 h / 30 °C / Inert atmosphere; Large scale reaction
2.2: 7 h / 30 - 70 °C / Inert atmosphere
2.3: 1 h / 35 °C / Inert atmosphere
3.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction
View Scheme
Multi-step reaction with 2 steps
1: chlorosulfonic acid / Inert atmosphere
2: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction
View Scheme
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

A

C12H11FN2O2S

C12H11FN2O2S

B

C13H15FN2O5S2

C13H15FN2O5S2

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction
2.1: sulfur trioxide / ethyl acetate / 19 h / 30 °C / Inert atmosphere; Large scale reaction
2.2: 7 h / 30 - 70 °C / Inert atmosphere
2.3: 1 h / 35 °C / Inert atmosphere
3.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction
4.1: triethylamine / tetrahydrofuran / -10 - 0 °C / Inert atmosphere; Large scale reaction
View Scheme
Multi-step reaction with 3 steps
1: chlorosulfonic acid / Inert atmosphere
2: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction
3: triethylamine / tetrahydrofuran / -10 - 0 °C / Inert atmosphere; Large scale reaction
View Scheme
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

(S)-4-fluoro-N-[1-(3-hydroxypropylamino)propan-2-yl]isoquinoline-5-sulfonamide oxalate

(S)-4-fluoro-N-[1-(3-hydroxypropylamino)propan-2-yl]isoquinoline-5-sulfonamide oxalate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction
2.1: sulfur trioxide / ethyl acetate / 19 h / 30 °C / Inert atmosphere; Large scale reaction
2.2: 7 h / 30 - 70 °C / Inert atmosphere
2.3: 1 h / 35 °C / Inert atmosphere
3.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction
4.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 20 h / -10 - 0 °C / Inert atmosphere; Large scale reaction
4.2: 0 - 25 °C / Inert atmosphere; Large scale reaction
4.3: 0.58 h / 75 °C / Inert atmosphere; Large scale reaction
View Scheme
Multi-step reaction with 3 steps
1.1: chlorosulfonic acid / Inert atmosphere
2.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction
3.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 20 h / -10 - 0 °C / Inert atmosphere; Large scale reaction
3.2: 0 - 25 °C / Inert atmosphere; Large scale reaction
3.3: 0.58 h / 75 °C / Inert atmosphere; Large scale reaction
View Scheme
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline hydrochloride
223644-02-8

4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction
2.1: sulfur trioxide / ethyl acetate / 19 h / 30 °C / Inert atmosphere; Large scale reaction
2.2: 7 h / 30 - 70 °C / Inert atmosphere
2.3: 1 h / 35 °C / Inert atmosphere
3.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction
4.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 20 h / -10 - 0 °C / Inert atmosphere; Large scale reaction
4.2: 0 - 25 °C / Inert atmosphere; Large scale reaction
4.3: 0.58 h / 75 °C / Inert atmosphere; Large scale reaction
5.1: potassium carbonate / dichloromethane; water / 1 h / 20 °C / Inert atmosphere; Large scale reaction
5.2: 0.5 h / 25 °C / Inert atmosphere; Large scale reaction
5.3: 5 - 15 °C / Inert atmosphere; Large scale reaction
View Scheme
Multi-step reaction with 4 steps
1.1: chlorosulfonic acid / Inert atmosphere
2.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere; Large scale reaction
3.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 20 h / -10 - 0 °C / Inert atmosphere; Large scale reaction
3.2: 0 - 25 °C / Inert atmosphere; Large scale reaction
3.3: 0.58 h / 75 °C / Inert atmosphere; Large scale reaction
4.1: potassium carbonate / dichloromethane; water / 1 h / 20 °C / Inert atmosphere; Large scale reaction
4.2: 0.5 h / 25 °C / Inert atmosphere; Large scale reaction
4.3: 5 - 15 °C / Inert atmosphere; Large scale reaction
View Scheme
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

A

4-fluoroisoquinoline-5-sulfonic acid
906820-10-8

4-fluoroisoquinoline-5-sulfonic acid

B

4-fluoroisoquinoline-8-sulfonic acid
1334294-09-5

4-fluoroisoquinoline-8-sulfonic acid

Conditions
ConditionsYield
With sulfuric acid; sulfur trioxide at 30℃; for 4h; Inert atmosphere;
Multi-step reaction with 2 steps
1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction
2: sulfur trioxide / 19 h / 30 °C / Inert atmosphere
View Scheme
With phosphotungstic acid; sulfuric acid; sulfur trioxide at 30℃; for 3h; Reagent/catalyst; Temperature;
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

4-fluoro-5-isoquinolinesulfonyl chloride
194032-33-2

4-fluoro-5-isoquinolinesulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid; potassium nitrate / 12 h / 25 °C / Inert atmosphere
2.1: zinc; ammonium chloride / water; tetrahydrofuran / 5 h / 25 °C / Inert atmosphere
3.1: hydrogenchloride; sodium nitrate / water / 1 h / -15 °C / Inert atmosphere
3.2: 2 h / -5 - 0 °C
View Scheme
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

A

4-fluoro-5-isoquinolinesulfonyl chloride
194032-33-2

4-fluoro-5-isoquinolinesulfonyl chloride

B

C9H5ClFNO2S

C9H5ClFNO2S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sulfuric acid / acetone / 2 h / 0 - 10 °C / Inert atmosphere; Large scale reaction
2.1: sulfur trioxide / 19 h / 30 °C / Inert atmosphere; Large scale reaction
2.2: 7 h / 30 - 70 °C / Inert atmosphere
View Scheme
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

1-­bromo-4-fluoroisoquinoline
1421517-86-3

1-­bromo-4-fluoroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 14 h / 0 - 20 °C
2.1: tetrabutylammomium bromide / dichloromethane / 0.17 h / 20 °C / Inert atmosphere; Molecular sieve
2.2: 20 °C / Inert atmosphere
View Scheme
4-­fluoroisoquinoline
394-67-2

4-­fluoroisoquinoline

4-fluoroisoquinoline-5-amine
928664-14-6

4-fluoroisoquinoline-5-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid; potassium nitrate / 12 h / 25 °C / Inert atmosphere
2: zinc; ammonium chloride / water; tetrahydrofuran / 5 h / 25 °C / Inert atmosphere
View Scheme

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