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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,5-Dihydroxy-1,4-Dithiane supplier in China

Cas:40018-26-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

Name:1,4-Dithiane-2,5-diol Synonyms:p-Dithiane-2,5-diol CAS:40018-26-6 Name:1,4-Dithiane-2,5-diol Synonyms:p-Dithiane-2,5-diol ;2,5-Dihydroxy-1,4-dithiane Molecular Formula:C4H8O2S2 Molecular Weight:152.23 CAS:40018-26-6

CAS: 40018-26-6 p-Dithiane-2,5-diol

Cas:40018-26-6

Min.Order:1 Kilogram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1,4-dithiane-2,5-diol

Cas:40018-26-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price 99% Food Grade 2,5-Dihydroxy-1,4-dithiane 40018-26-6 Kosher Manufacturer

Cas:40018-26-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Tengzhou Runlong Fragrance Co., Ltd.

1、Our factory passed ISO 9001, ISO 14001, ISO 22000 system certification; HALAL 、KOSHER、FCC AND FDA certificate are available. We can provide customers with better prices, and the supply is stable. 2、We founded in 2004,10% of the staff have more tha

2,5-Dihydroxy-1,4-Dithiane, CAS NO.40018-26-6

Cas:40018-26-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

p-Dithiane-2,5-diol 40018-26-6 /manufacturer/low price/high quality/in stock

Cas:40018-26-6

Min.Order:1 Kilogram

FOB Price: $11.0 / 12.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,5-Dihydroxy-1,4-dithiane

Cas:40018-26-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

p-Dithiane-2,5-diol Basic information Product Name: p-Dithiane-2,5-diol Synonyms: 1,4-DITHIANE-2,5-DIOL;2,5-DIHYDROXY-1,4-DITHIANE;4-DITHIANE-2,5-DIOL;MERCATOACETALDEHYDE DIMER;MERCAPTOA

TIANFU-CHEM - p-Dithiane-2,5-diol

Cas:40018-26-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

2,5-Dihydroxy-1,4-dithiane

Cas:40018-26-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 40018-26-6 with fast shipping

Cas:40018-26-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

p-Dithiane-2,5-diol

Cas:40018-26-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

CAS No : 40018-26-6 Molecular: C4H8O2S2 Molecular weight: 152.24 Structure: Specification: Appearance: white to off white crystalline powder Assay: 99.0%Min Melting point: 135 ℃ min. Loss on drying: 0.5% max. Sulphate ash: 0.2% m

2,5-dihydroxy-1,4-dithiane

Cas:40018-26-6

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

p-Dithiane-2,5-diol 40018-26-6

Cas:40018-26-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

2,5-Dihydroxy-1,4-dithiane

Cas:40018-26-6

Min.Order:1 Kilogram

FOB Price: $10.0 / 11.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

2,5-Dihydroxy-1,4-dithiane CAS:40018-26-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi

2,5-Dihydroxy-1,4-dithiane CAS:40018-26-6

Cas:40018-26-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer best service, company and transport

Factory wholesale 99% 2,5-Dihydroxy-1,4-dithiane; CAS:40018-26-6

Cas:40018-26-6

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Leader Biochemical Group

About Product Details

China Biggest Factory Manufacturer Supply 2,5-Dihydroxy-1,4-dithiane CAS 40018-26-6

Cas:40018-26-6

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:40018-26-6

Cas:40018-26-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

Hangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting 2,5-Dihydroxy-1,4-dithiane CAS:40018-26-6 , Please contact us by email freely. We are leading exporter in China. If you real

2,5-Dihydroxy-1,4-dithiane CAS:40018-26-6 from FandaChem

Cas:40018-26-6

Min.Order:1 Metric Ton

Negotiable

Type:Other

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

P-DITHIANE-2,5-DIOL

Cas:40018-26-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

p-Dithiane-2,5-diol

Cas:40018-26-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

p-Dithiane-2,5-diol

Cas:40018-26-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2,5-Dihydroxy-1,4-Dithiane

Cas:40018-26-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

2,5-Dihydroxy-1,4-DithianeAppearance:white or practically white crystalline powder Storage:STORE IN A COOL, DRY PLACE. STORE IN A TIGHTLY CLOSED CONTAINER. Package:according to customers' requirements Application:EMTRICITABINE&LAMIVUDINE INTERMEDIAT

2,5-Dihydroxy-1,4-Dithiane

Cas:40018-26-6

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

NIGNXIA XINDACHANG TECHNOLOGY CO.,LTD

Donglian as a factory and supplier of aroma chemicals in China, We can provide different quantities of custom synthesis chemicals in food flavor scale more than fourteen years.in addition, our company has researched and developed four series

p-Dithiane-2,5-diol

Cas:40018-26-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Siwei Development Group Ltd.

Product name: P-Dithiane-2,5-Diol CAS No.:40018-26-6 Molecule Formula:C4H8O2S2 Molecule Weight:152.24 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard

Best Quality P-Dithiane-2,5-Diol

Cas:40018-26-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2,5-Dihydroxy-1,4-dithiane Manufacturer/High quality/Best price/In stock

Cas:40018-26-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Factory Sells2,5-Dihydroxy-1,4-dithiane

Cas:40018-26-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2,5-Dihydroxy-1,4-dithiane

Cas:40018-26-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

2,5-Dihydroxy-1,4-dithiane Chemical Properties Melting point 130 °C (dec.) (lit.) Boiling point 244.73°C (rough estimate) density 1.224 (estimate) FEMA 3826 | 2,5-DIHYDROXY-1,4-DITHIANE refractive index 1.5200 (estimate) s

2,5-Dihydroxy-1,4-dithiane

Cas:40018-26-6

Min.Order:1 Kilogram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

Synthetic route

2-chloroethanal
107-20-0

2-chloroethanal

1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

Conditions
ConditionsYield
With sodium hydrogensulfide; water
With sodium hydroxide; hydrogen sulfide
2,5-diethoxy-[1,4]dithiane
408533-52-8

2,5-diethoxy-[1,4]dithiane

1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

Conditions
ConditionsYield
With hydrogenchloride
2,2-diethoxy-ethanethiol
53608-94-9

2,2-diethoxy-ethanethiol

1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

Conditions
ConditionsYield
With hydrogenchloride
2,2-dimethyl-1,3oxathiolan-5-one
35350-46-0

2,2-dimethyl-1,3oxathiolan-5-one

A

1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

B

2-Mercaptomethyl-[1,3]oxathiolan-5-ol

2-Mercaptomethyl-[1,3]oxathiolan-5-ol

Conditions
ConditionsYield
With diisobutylaluminium hydride In toluene at -78℃; for 2h;
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

methyl 2-diethylphosphono-4-methyl-2-pentenoate
660428-50-2

methyl 2-diethylphosphono-4-methyl-2-pentenoate

2-Isopropyl-2,5-dihydro-thiophene-3-carboxylic acid methyl ester
112177-95-4

2-Isopropyl-2,5-dihydro-thiophene-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane Heating;100%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

Benzoylacetonitrile
614-16-4

Benzoylacetonitrile

(2-amino-thien-3-yl)phenylmethanone
21582-44-5

(2-amino-thien-3-yl)phenylmethanone

Conditions
ConditionsYield
With triethylamine In 2,2,2-trifluoroethanol at 60℃; for 6.5h; Gewald Aminoheterocycles Synthesis; Microwave irradiation;100%
Stage #1: 1,4-dithiane-2,5-diol; Benzoylacetonitrile In ethanol at 20℃; for 0.166667h;
Stage #2: With N-methylpiperazine-functionalized Polyacrylonitrile Fiber In ethanol for 5h; Gewald Aminoheterocycles Synthesis; Reflux;
83%
With diethylamine In ethanol at 50℃; for 4h;64%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

cyanoacetic acid amide
107-91-5

cyanoacetic acid amide

2-aminothiophene-3-carboxamide
14080-51-4

2-aminothiophene-3-carboxamide

Conditions
ConditionsYield
With triethylamine In ethanol at 68℃; for 12h; Gewald Aminoheterocycles Synthesis; Inert atmosphere;100%
With triethylamine In ethanol at 20℃; for 2.08333h; Heating / reflux;88%
Stage #1: 1,4-dithiane-2,5-diol; cyanoacetic acid amide In ethanol at 20℃; for 0.166667h;
Stage #2: With N-methylpiperazine-functionalized Polyacrylonitrile Fiber In ethanol for 4h; Gewald Aminoheterocycles Synthesis; Reflux;
87%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

L-menthol glyoxylate monohydrate
111969-64-3

L-menthol glyoxylate monohydrate

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-hydroxy-1,3-oxathiolane-2-carboxylate
200396-19-6

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-hydroxy-1,3-oxathiolane-2-carboxylate

Conditions
ConditionsYield
Stage #1: L-menthyl glyoxylate monohydrate With acetic acid In toluene at 110 - 115℃;
Stage #2: 1,4-dithiane-2,5-diol In toluene Heating;
100%
Stage #1: 1,4-dithiane-2,5-diol With acetic acid In acetonitrile at 40 - 45℃; for 0.166667h;
Stage #2: L-menthyl glyoxylate monohydrate In acetonitrile at 90℃; for 0.166667h;
88%
Stage #1: L-menthyl glyoxylate monohydrate With acetic acid In toluene at 110 - 111℃; for 3h;
Stage #2: 1,4-dithiane-2,5-diol In toluene at 85 - 90℃; for 2h;
Stage #3: With triethylamine In n-heptane at 0 - 5℃; for 6h;
80%
Stage #1: L-menthyl glyoxylate monohydrate With acetic acid In toluene at 120℃; for 2h; Dean-Stark;
Stage #2: 1,4-dithiane-2,5-diol In toluene for 4h; Reflux;
Stage #3: With triethylamine In hexane; toluene at 0℃; for 16h;
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

3-amino-2-propanol
78-96-6, 1674-56-2

3-amino-2-propanol

1-(di(thiiran-2-yl)amino)propan-2-ol

1-(di(thiiran-2-yl)amino)propan-2-ol

Conditions
ConditionsYield
With toluene-4-sulfonic acid In ethanol at 20℃; Reflux; Inert atmosphere;100%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

3-amino-2-propanol
78-96-6, 1674-56-2

3-amino-2-propanol

C7H13NOS2

C7H13NOS2

Conditions
ConditionsYield
With toluene-4-sulfonic acid In ethanol for 2h; Reagent/catalyst; Reflux;100%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

5-(4-chlorophenyl)-1-phenylpent-2-en-4-yn-1-one

5-(4-chlorophenyl)-1-phenylpent-2-en-4-yn-1-one

C19H15ClO2S

C19H15ClO2S

Conditions
ConditionsYield
With 3-{[(S)-{5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl}(6-methoxyquinolin-4-yl)methyl]amino}-4-[(2-fluorophenyl)amino]cyclobut-3-ene-1,2-dione In toluene at 60℃; for 6h; enantioselective reaction;99.5%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

1-(2-thienyl)-2-nitroethene
34312-77-1

1-(2-thienyl)-2-nitroethene

4-nitro-5-(thiophen-2-yl)tetrahydrothiophen-3-ol

4-nitro-5-(thiophen-2-yl)tetrahydrothiophen-3-ol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; tandem Michael-intramolecular Henry reaction; Inert atmosphere;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

(E)-2,4-dimethoxy-β-nitrostyrene
37630-19-6

(E)-2,4-dimethoxy-β-nitrostyrene

5-(2,4-dimethoxyphenyl)-4-nitrotetrahydrothiophen-3-ol

5-(2,4-dimethoxyphenyl)-4-nitrotetrahydrothiophen-3-ol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; tandem Michael-intramolecular Henry reaction; Inert atmosphere;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

(E)-1-methoxy-4-(2-nitrovinyl)benzene
3179-10-0, 5576-97-6

(E)-1-methoxy-4-(2-nitrovinyl)benzene

5-(4-methoxyphenyl)-4-nitrotetrahydrothiophen-3-ol

5-(4-methoxyphenyl)-4-nitrotetrahydrothiophen-3-ol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; tandem Michael-intramolecular Henry reaction; Inert atmosphere;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

1-[(E)-2-nitroethenyl]naphthalene
4735-49-3, 37630-26-5

1-[(E)-2-nitroethenyl]naphthalene

5-naphthalen-1-yl-4-nitrotetrahydrothiophen-3-ol

5-naphthalen-1-yl-4-nitrotetrahydrothiophen-3-ol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; tandem Michael-intramolecular Henry reaction; Inert atmosphere;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

trans-2,4-dichloro-β-nitrostyrene
18984-21-9, 34209-97-7

trans-2,4-dichloro-β-nitrostyrene

5-(2,4-dichlorophenyl)-4-nitrotetrahydrothiophen-3-ol

5-(2,4-dichlorophenyl)-4-nitrotetrahydrothiophen-3-ol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; tandem Michael-intramolecular Henry reaction; Inert atmosphere;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
959-33-1

3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one

((2R,3S,4S)-4-hydroxy-2-(4-methoxyphenyl)tetrahydrothiophen-3-yl)(phenyl)methanone
1357912-54-9

((2R,3S,4S)-4-hydroxy-2-(4-methoxyphenyl)tetrahydrothiophen-3-yl)(phenyl)methanone

Conditions
ConditionsYield
With potassium fluoride; C46H34I4O6 In dichloromethane at 20℃; for 24h; Schlenk technique; Inert atmosphere; stereoselective reaction;99%
With C32H28F6N4O3 In toluene at 60℃; for 6h; optical yield given as %ee; enantioselective reaction;91%
In water for 12h; Reflux;60%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

(E)-3-(4-chloro-benzylidene)-chroman-4-one
61661-20-9, 61926-52-1, 62174-08-7

(E)-3-(4-chloro-benzylidene)-chroman-4-one

(2'SR,3SR,4'SR)-2'-(4-chlorophenyl)-4'-hydroxy-4',5'-dihydro-2'H-spiro[chromane-3,3'-thiophen]-4-one

(2'SR,3SR,4'SR)-2'-(4-chlorophenyl)-4'-hydroxy-4',5'-dihydro-2'H-spiro[chromane-3,3'-thiophen]-4-one

B

2'-(4-chlorophenyl)-4'-hydroxy-4',5'-dihydro-2'H-spiro[chromane-3,3'-thiophen]-4-one

2'-(4-chlorophenyl)-4'-hydroxy-4',5'-dihydro-2'H-spiro[chromane-3,3'-thiophen]-4-one

Conditions
ConditionsYield
With triethylamine In toluene at 80℃; for 0.5h; diastereoselective reaction;A n/a
B 99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

(E)-3-[(pyridin-3-yl)methylene]chroman-4-one

(E)-3-[(pyridin-3-yl)methylene]chroman-4-one

A

(2'S,3S,4'S)-4'-hydroxy-2'-(pyridin-3-yl)-4',5'-dihydro-2'H-spiro[chroman-3,3'-thiophen]-4-one

(2'S,3S,4'S)-4'-hydroxy-2'-(pyridin-3-yl)-4',5'-dihydro-2'H-spiro[chroman-3,3'-thiophen]-4-one

B

C17H15NO3S

C17H15NO3S

C

C17H15NO3S

C17H15NO3S

Conditions
ConditionsYield
Stage #1: (E)-3-[(pyridin-3-yl)methylene]chroman-4-one With C31H29F3N4O3; magnesium sulfate In toluene at 20℃; for 0.25h;
Stage #2: 1,4-dithiane-2,5-diol In toluene at 55℃; enantioselective reaction;
A 99%
B n/a
C n/a
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

3-[(4-bromophenyl)methylene]-2,3-dihydro-4H-1-benzopyran-4-one
74074-04-7, 101001-05-2

3-[(4-bromophenyl)methylene]-2,3-dihydro-4H-1-benzopyran-4-one

A

(2'S,3S,4'S)-2-(4-bromophenyl)-4'-hydroxy-4',5'-dihydro-2'H-spiro[chroman-3,3'-thiophen]-4-one

(2'S,3S,4'S)-2-(4-bromophenyl)-4'-hydroxy-4',5'-dihydro-2'H-spiro[chroman-3,3'-thiophen]-4-one

B

C18H15BrO3S

C18H15BrO3S

Conditions
ConditionsYield
Stage #1: 3-[(4-bromophenyl)methylene]-2,3-dihydro-4H-1-benzopyran-4-one With C31H29F3N4O3; magnesium sulfate In toluene at 20℃; for 0.25h;
Stage #2: 1,4-dithiane-2,5-diol In toluene at 55℃; enantioselective reaction;
A 99%
B n/a
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

3-[(2-bromophenyl)methylene]-2,3-dihydro-4H-1-benzopyran-4-one

3-[(2-bromophenyl)methylene]-2,3-dihydro-4H-1-benzopyran-4-one

A

(2'R,3S,4'S)-2'-(2-bromophenyl)-4'-hydroxy-4',5'-dihydro-2'H-spiro[chroman-3,3'-thiophen]-4-one

(2'R,3S,4'S)-2'-(2-bromophenyl)-4'-hydroxy-4',5'-dihydro-2'H-spiro[chroman-3,3'-thiophen]-4-one

B

C18H15BrO3S

C18H15BrO3S

C

C18H15BrO3S

C18H15BrO3S

Conditions
ConditionsYield
Stage #1: 3-[(2-bromophenyl)methylene]-2,3-dihydro-4H-1-benzopyran-4-one With C31H29F3N4O3; magnesium sulfate In toluene at 20℃; for 0.25h;
Stage #2: 1,4-dithiane-2,5-diol In toluene at 55℃; enantioselective reaction;
A 99%
B n/a
C n/a
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

(2R,2'S,4'R)-4'-hydroxy-2'-phenyl-4',5'-dihydro-2'H,3H-spiro[benzofuran-2,3'-thiophen]-3-one

(2R,2'S,4'R)-4'-hydroxy-2'-phenyl-4',5'-dihydro-2'H,3H-spiro[benzofuran-2,3'-thiophen]-3-one

Conditions
ConditionsYield
With C31H26F6N4O2 In 1,4-dioxane at 10℃; for 72h; enantioselective reaction;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

3,4,5-trimethoxychalcone
127034-55-3, 60246-63-1

3,4,5-trimethoxychalcone

((2R,3S,4S)-4-hydroxy-2-(3,4,5-trimethoxyphenyl)tetrahydrothiophen-3-yl)(phenyl)methanone

((2R,3S,4S)-4-hydroxy-2-(3,4,5-trimethoxyphenyl)tetrahydrothiophen-3-yl)(phenyl)methanone

Conditions
ConditionsYield
With potassium fluoride; C46H34I4O6 In dichloromethane at 20℃; for 24h; Schlenk technique; Inert atmosphere; stereoselective reaction;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

((2R,3S,4S)-2-(4-fluorophenyl)-4-hydroxytetrahydrothiophen-3-yl)(phenyl)methanone
1357912-51-6

((2R,3S,4S)-2-(4-fluorophenyl)-4-hydroxytetrahydrothiophen-3-yl)(phenyl)methanone

Conditions
ConditionsYield
With potassium fluoride; C46H34I4O6 In dichloromethane at 20℃; for 24h; Schlenk technique; Inert atmosphere; stereoselective reaction;99%
With potassium fluoride; C46H34I4O6 In dichloromethane at 20℃; Inert atmosphere; stereoselective reaction;
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

4-bromo-4'-methoxychalcone
92873-00-2

4-bromo-4'-methoxychalcone

((2R,3S,4S)-2-(4-bromophenyl)-4-hydroxytetrahydrothiophen-3-yl)(4-methoxyphenyl)methanone

((2R,3S,4S)-2-(4-bromophenyl)-4-hydroxytetrahydrothiophen-3-yl)(4-methoxyphenyl)methanone

Conditions
ConditionsYield
With potassium fluoride; C46H34I4O6 In dichloromethane at 20℃; for 24h; Schlenk technique; Inert atmosphere; stereoselective reaction;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

4-bromobenzal-4'-methylacetophenone
13565-40-7, 7020-14-6

4-bromobenzal-4'-methylacetophenone

((2R,3S,4S)-2-(4-bromophenyl)-4-hydroxytetrahydrothiophen-3-yl)(p-tolyl)methanone

((2R,3S,4S)-2-(4-bromophenyl)-4-hydroxytetrahydrothiophen-3-yl)(p-tolyl)methanone

Conditions
ConditionsYield
With potassium fluoride; C46H34I4O6 In dichloromethane at 20℃; for 24h; Schlenk technique; Inert atmosphere; stereoselective reaction;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

(4-fluorophenyl)((2R,3S,4S)-2-(4-fluorophenyl)-4-hydroxytetrahydrothiophen-3-yl)methanone

(4-fluorophenyl)((2R,3S,4S)-2-(4-fluorophenyl)-4-hydroxytetrahydrothiophen-3-yl)methanone

Conditions
ConditionsYield
With potassium fluoride; C46H34I4O6 In dichloromethane at 20℃; for 24h; Schlenk technique; Inert atmosphere; stereoselective reaction;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

C12H8Cl2N2O3

C12H8Cl2N2O3

5-(3,4-dichlorophenyl)-4-(3-methyl-4-nitroisoxazol-5-yl)tetrahydrothiophen-3-ol

5-(3,4-dichlorophenyl)-4-(3-methyl-4-nitroisoxazol-5-yl)tetrahydrothiophen-3-ol

Conditions
ConditionsYield
In ethanol at 80℃;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

3-Methyl-4-nitro-5-[(E)-2-(4-nitro-phenyl)-vinyl]-isoxazole
78080-53-2

3-Methyl-4-nitro-5-[(E)-2-(4-nitro-phenyl)-vinyl]-isoxazole

4-(3-methyl-4-nitroisoxazol-5-yl)-5-(4-nitrophenyl)tetrahydrothiophen-3-ol

4-(3-methyl-4-nitroisoxazol-5-yl)-5-(4-nitrophenyl)tetrahydrothiophen-3-ol

Conditions
ConditionsYield
In ethanol at 80℃;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

C12H9N3O5

C12H9N3O5

4-(3-methyl-4-nitroisoxazol-5-yl)-5-(3-nitrophenyl)tetrahydrothiophen-3-ol

4-(3-methyl-4-nitroisoxazol-5-yl)-5-(3-nitrophenyl)tetrahydrothiophen-3-ol

Conditions
ConditionsYield
In ethanol at 80℃;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

C12H9N3O5

C12H9N3O5

4-(3-methyl-4-nitroisoxazol-5-yl)-5-(2-nitrophenyl)tetrahydrothiophen-3-ol

4-(3-methyl-4-nitroisoxazol-5-yl)-5-(2-nitrophenyl)tetrahydrothiophen-3-ol

Conditions
ConditionsYield
In ethanol at 80℃;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

2,6-di-tert-butyl-4-benzylidene-cyclohexa-2,5-dienone
7078-98-0

2,6-di-tert-butyl-4-benzylidene-cyclohexa-2,5-dienone

2-(((3,5-bis-tert-butyl-4-hydroxyphenyl)(phenyl)methyl)thio)acetaldehyde

2-(((3,5-bis-tert-butyl-4-hydroxyphenyl)(phenyl)methyl)thio)acetaldehyde

Conditions
ConditionsYield
With methanol; P(p-C6H4F)3 at 20℃; for 24h;99%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

methyl vinyl ketone
78-94-4

methyl vinyl ketone

3-acetyl-4-hydroxy-tetrahydrothiophene
564486-00-6

3-acetyl-4-hydroxy-tetrahydrothiophene

Conditions
ConditionsYield
With 1,3-dicyclohexylimidazolium-2-carboxylate In tetrahydrofuran at 21℃; for 2h; Michael Addition;98%
With triethylamine In dichloromethane 1.) 5 deg C, 45 min, 2.) 23 deg C, 17 h, 3.) reflux, 1 h;48%
1,4-dithiane-2,5-diol
40018-26-6

1,4-dithiane-2,5-diol

malononitrile
109-77-3

malononitrile

2-amino-3-cyanothiophene
4651-82-5

2-amino-3-cyanothiophene

Conditions
ConditionsYield
With triethylamine In methanol at 70℃; for 0.5h;98%
Stage #1: 1,4-dithiane-2,5-diol; malononitrile In ethanol at 20℃; for 0.166667h;
Stage #2: With N-methylpiperazine-functionalized Polyacrylonitrile Fiber In ethanol for 2h; Gewald Aminoheterocycles Synthesis; Reflux;
91%
With triethylamine; N,N-dimethyl-formamide In methanol at 50℃; for 0.0333333h; microwave irradiation;81%

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