Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&D b
Cas:443913-73-3
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
1. high purity 2. able to provide COA/HNMR/HPLC 3. High quality 4. low price 5. Best service Appearance:white powder Storage:rm Package:bag/bottle/drum Application:anti cancer Transportation:common transportation Port:Shanghai, Wuhan
Cas:443913-73-3
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
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Min.Order:1 Kilogram
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryName Vandetanib CAS 443913-73-3 EINECS 1806241-263-5 MF C22H24BrFN4O2
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:443913-73-3
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inquirySuperlist Name: Vandetanib Formula: C22H24BrFN4O2 Synonyms: 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline;CH 331;ZD 6474;Zactima;N-(4-bromo-2-fluoro-phenyl)-6-methoxy-7-[(1-methyl-4-piperidyl)methoxy]quinazo
Cas:443913-73-3
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,
Vandetanib CAS:443913-73-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:443913-73-3
Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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Min.Order:1 Gram
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inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:443913-73-3
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryVandetanib CAS:443913-73-3 Appearance Off-white powder Purity/HPLC ≥99% Single impurity ≤0.10% HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten
Cas:443913-73-3
Min.Order:10 Gram
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inquiryAdvantages: WuHan HanSheng New Material is a renowned pharmaceutical manufacturer. We can offer high-quality products at competitive prices in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our phil
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:443913-73-3
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Type:Lab/Research institutions
inquiryLorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
Cas:443913-73-3
Min.Order:100 Metric Ton
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Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:443913-73-3
Min.Order:0 Metric Ton
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inquiryVandetanib is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:White to off-white solid Storage:Room temperature, Keep in Dark Place. Package:According to the demand of customer Applic
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:443913-73-3
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Type:Trading Company
inquiryformaldehyd
4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester
vandetanib
Conditions | Yield |
---|---|
Stage #1: formaldehyd; 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester With formic acid In water at 80℃; for 6.5 - 8.5h; Stage #2: With potassium hydroxide In methanol; water at 60℃; for 2h; Product distribution / selectivity; | 94% |
Stage #1: formaldehyd; 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester With formic acid In water at 80℃; for 5 - 6.5h; Stage #2: With sodium hydroxide In tetrahydrofuran; water at 40℃; Product distribution / selectivity; | 90.6% |
Stage #1: formaldehyd; 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester With formic acid; water at 95℃; for 4h; Stage #2: With sodium hydroxide In water pH=10.5; Product distribution / selectivity; | 88% |
Stage #1: formaldehyd; 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester With formic acid In water at 81℃; for 5h; Stage #2: With potassium hydroxide In tetrahydrofuran; water at 40℃; Product distribution / selectivity; | 80.3% |
4-bromo-2-fluoroaniline
4-chloro-6-methoxy-7-[(1'-methylpiperidin-4'-yl)methoxy]-quinazoline
vandetanib
Conditions | Yield |
---|---|
In isopropyl alcohol at 80℃; for 0.533333h; Microwave irradiation; | 89% |
Conditions | Yield |
---|---|
With sodium triacetoxyborohydride; acetic acid In methanol; dichloromethane; water at 20℃; for 2h; | 85% |
Stage #1: formaldehyd; N-Desmethylvandetanib With formic acid at 95℃; for 4h; Stage #2: With sodium hydroxide In water pH=11; | 45% |
With sodium cyanoborohydride In tetrahydrofuran; methanol at 18 - 25℃; for 1h; Product distribution / selectivity; |
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride; acetic acid In methanol; dichloromethane at 20℃; for 2h; | 84% |
formaldehyd
formic acid
4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester
vandetanib
Conditions | Yield |
---|---|
Stage #1: 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester With hydrogenchloride In methanol; water at 20℃; Stage #2: formaldehyd; formic acid at 20℃; | 78% |
vandetanib
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane; water Product distribution / selectivity; Saturated solution; |
4-bromo-2-fluoroaniline
vandetanib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogenchloride / isopropyl alcohol / 2 h / Reflux 2: trifluoroacetic acid / 1 h / Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C 4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 5: sodium triacetoxyborohydride; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: acetic acid / 1 h / 130 °C / Irradiation 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C View Scheme |
7-benzyloxy-4-chloro-6-methoxyquinazoline
vandetanib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogenchloride / isopropyl alcohol / 2 h / Reflux 2: trifluoroacetic acid / 1 h / Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C 4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 5: sodium triacetoxyborohydride; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C View Scheme |
4-(4-bromo-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline
vandetanib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 3: sodium triacetoxyborohydride; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C View Scheme |
7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine hydrochloride
vandetanib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: trifluoroacetic acid / 1 h / Reflux 2: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C 3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 4: sodium triacetoxyborohydride; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C View Scheme |
vandetanib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: trifluoroacetic acid / 0.75 h / 70 °C / Irradiation 2: caesium carbonate / acetonitrile / 3 h / Reflux 3: acetic acid / 1 h / 130 °C / Irradiation 4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 5: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C View Scheme |
vandetanib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: caesium carbonate / acetonitrile / 3 h / Reflux 2: acetic acid / 1 h / 130 °C / Irradiation 3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 4: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C View Scheme |
3-methoxy-4-hydroxybenzonitrile
vandetanib
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2: acetic anhydride; nitric acid 3: tert-butylamine hydrochloride; sodium dithionite; sodium hydrogencarbonate / dichloromethane; water / 2 h 4: 0.25 h / 90 °C / Irradiation 5: trifluoroacetic acid / 0.75 h / 70 °C / Irradiation 6: caesium carbonate / acetonitrile / 3 h / Reflux 7: acetic acid / 1 h / 130 °C / Irradiation 8: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 9: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: potassium carbonate / acetonitrile / 0.17 h / 20 °C 1.2: 5 h / Reflux 2.1: acetic acid; nitric acid / 2 h / Cooling with ice 3.1: palladium 10% on activated carbon; hydrogen / methanol / 2327.23 Torr 4.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C 5.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C 6.1: hydrogenchloride / methanol; water / 20 °C 6.2: 20 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: potassium carbonate / acetonitrile / 0.17 h / 20 °C 1.2: 5 h / Reflux 2.1: acetic acid; nitric acid / 2 h / Cooling with ice 3.1: palladium 10% on activated carbon; hydrogen / methanol / 2327.23 Torr 4.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C 5.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C 6.1: hydrogenchloride / methanol; water / 20 °C 6.2: 20 °C View Scheme |
4-(benzyloxy)-3-methoxybenzonitrile
vandetanib
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: acetic anhydride; nitric acid 2: tert-butylamine hydrochloride; sodium dithionite; sodium hydrogencarbonate / dichloromethane; water / 2 h 3: 0.25 h / 90 °C / Irradiation 4: trifluoroacetic acid / 0.75 h / 70 °C / Irradiation 5: caesium carbonate / acetonitrile / 3 h / Reflux 6: acetic acid / 1 h / 130 °C / Irradiation 7: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 8: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: acetic acid; nitric acid / 2 h / Cooling with ice 2.1: palladium 10% on activated carbon; hydrogen / methanol / 2327.23 Torr 3.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C 4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C 5.1: hydrogenchloride / methanol; water / 20 °C 5.2: 20 °C View Scheme |
4-(benzyloxy)-5-methoxy-2-nitrobenzonitrile
vandetanib
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: tert-butylamine hydrochloride; sodium dithionite; sodium hydrogencarbonate / dichloromethane; water / 2 h 2: 0.25 h / 90 °C / Irradiation 3: trifluoroacetic acid / 0.75 h / 70 °C / Irradiation 4: caesium carbonate / acetonitrile / 3 h / Reflux 5: acetic acid / 1 h / 130 °C / Irradiation 6: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 7: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: palladium 10% on activated carbon; hydrogen / methanol / 2327.23 Torr 2.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C 4.1: hydrogenchloride / methanol; water / 20 °C 4.2: 20 °C View Scheme |
2-amino-4-(benzyloxy)-5-methoxybenzonitrile
vandetanib
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 0.25 h / 90 °C / Irradiation 2: trifluoroacetic acid / 0.75 h / 70 °C / Irradiation 3: caesium carbonate / acetonitrile / 3 h / Reflux 4: acetic acid / 1 h / 130 °C / Irradiation 5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 6: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C View Scheme |
vandetanib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C 3.1: hydrogenchloride / methanol; water / 20 °C 3.2: 20 °C View Scheme |
vandetanib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C 3.1: hydrogenchloride / methanol; water / 20 °C 3.2: 20 °C View Scheme |
Conditions | Yield |
---|---|
With copper(l) iodide; N1, N2-diphenethyloxalamide; sodium t-butanolate In 1,4-dioxane for 24h; Schlenk technique; Inert atmosphere; Molecular sieve; Heating; | 75% |
vandetanib
Conditions | Yield |
---|---|
With bis(3,5-bis(trifluoromethyl)phenyl)(2-(2,4,6-triisopropylphenyl)-1H-inden-3-yl)phosphine; bis(dibenzylideneacetone)-palladium(0) In acetonitrile at 120℃; for 16h; Inert atmosphere; Sealed tube; | 73% |
vandetanib
Conditions | Yield |
---|---|
With pyridine hydrochloride at 190 - 200℃; for 1.33333h; | 17% |
vandetanib
Conditions | Yield |
---|---|
With water In tetrahydrofuran at 20 - 50℃; for 28.333 - 292.333h; Product distribution / selectivity; |
ethylenediamine
vandetanib
Conditions | Yield |
---|---|
Stage #1: 2,2’,2”-nitrilotris(ethane-2,1-diyl)tris(1H-imidazole-1-carboxylate); vandetanib With triethylamine In dimethyl sulfoxide at 20℃; Stage #2: ethylenediamine In dimethyl sulfoxide at 20℃; for 24h; | |
Stage #1: 2,2’,2”-nitrilotris(ethane-2,1-diyl)tris(1H-imidazole-1-carboxylate); vandetanib With triethylamine In dimethyl sulfoxide at 20℃; Stage #2: ethylenediamine In dimethyl sulfoxide for 24h; Stage #3: With trifluoroacetic acid In dimethyl sulfoxide |
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