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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&D b

Vandetanib/ LIDE PHARMA- Factory supply / Best price

Cas:443913-73-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways focus on: -Pharmaceutical raw materials -Chemical raw materials -Food additives -Flavors and fragrances -Feed additives -Plant extracts -Veterinary raw materials We could supply you: -Best quality -Competitive price

Vandetanib 443913-73-3

Cas:443913-73-3

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Trading Company

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an

Vandetanib

Cas:443913-73-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hubei DiBo chemical co., LTD

National Professional and Technical Manufacturers Hot Selling Vantanil Raw Materials 443913-73-3 with COA, High Content Vantanil Price, Standard Specification Vantanil Spot, Vantanil Manufacturers Direct Selling Vandetanib Chinese alias:

Vandetanib /Cas:443913-73-3 /99.8%

Cas:443913-73-3

Min.Order:25 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Vandetanib

Cas:443913-73-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Vandetanib

Cas:443913-73-3

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Vandetanib 443913-73-3 GMP Manufacturer

Cas:443913-73-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Vandetanib

Cas:443913-73-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Vandetanib

Cas:443913-73-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

Vandetanib

Cas:443913-73-3

Min.Order:1000 Gram

FOB Price: $1800.0

Type:Trading Company

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Hubei Vanz Pharm Co.,Ltd

1. high purity 2. able to provide COA/HNMR/HPLC 3. High quality 4. low price 5. Best service Appearance:white powder Storage:rm Package:bag/bottle/drum Application:anti cancer Transportation:common transportation Port:Shanghai, Wuhan

low price, high quality Vandetanib

Cas:443913-73-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM---Vandetanib

Cas:443913-73-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Vandetanib CAS 443913-73-3 Treatment of Thyroid Cancer

Cas:443913-73-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 443913-73-3 with competitive price

Cas:443913-73-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name Vandetanib CAS 443913-73-3 EINECS 1806241-263-5 MF C22H24BrFN4O2

Vandetanib

Cas:443913-73-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

High quality CAS443913-73-3 Vandetanib with best price

Cas:443913-73-3

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

Superlist Name: Vandetanib Formula: C22H24BrFN4O2 Synonyms: 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline;CH 331;ZD 6474;Zactima;N-(4-bromo-2-fluoro-phenyl)-6-methoxy-7-[(1-methyl-4-piperidyl)methoxy]quinazo

High quality Vandetanib

Cas:443913-73-3

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

Vandetanib

Cas:443913-73-3

Min.Order:1 Gram

FOB Price: $15.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Vandetanib CAS:443913-73-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Vandetanib CAS:443913-73-3

Cas:443913-73-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Quinazolinamine,N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-

Cas:443913-73-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Vandetanib manufacturer with low price

Cas:443913-73-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Anti-Cancer powder CAS 443913-73-3 Vandetanib

Cas:443913-73-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

Vandetanib CAS:443913-73-3 Appearance Off-white powder Purity/HPLC ≥99% Single impurity ≤0.10% HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten

Vandetanib stock with the competitive price

Cas:443913-73-3

Min.Order:10 Gram

Negotiable

Type:Other

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Wuhan Han Sheng New Material Technology Co.,Ltd

Advantages: WuHan HanSheng New Material is a renowned pharmaceutical manufacturer. We can offer high-quality products at competitive prices in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our phil

Vandetanib

Cas:443913-73-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Quinazolinamine,N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-

Cas:443913-73-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

Vandetanib

Cas:443913-73-3

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

High purity 443913-73-3High quality 443913-73-3Vandetanib Good Supplier

Cas:443913-73-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Nanjing Fred Technology Co.,Ltd.

Vandetanib is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:White to off-white solid Storage:Room temperature, Keep in Dark Place. Package:According to the demand of customer Applic

Vandetanib

Cas:443913-73-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Vandetanib

Cas:443913-73-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

99% Vandetanib CAS 443913-73-3 with Best Price

Cas:443913-73-3

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

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Synthetic route

formaldehyd
50-00-0

formaldehyd

4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester
338992-20-4

4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Stage #1: formaldehyd; 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester With formic acid In water at 80℃; for 6.5 - 8.5h;
Stage #2: With potassium hydroxide In methanol; water at 60℃; for 2h; Product distribution / selectivity;
94%
Stage #1: formaldehyd; 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester With formic acid In water at 80℃; for 5 - 6.5h;
Stage #2: With sodium hydroxide In tetrahydrofuran; water at 40℃; Product distribution / selectivity;
90.6%
Stage #1: formaldehyd; 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester With formic acid; water at 95℃; for 4h;
Stage #2: With sodium hydroxide In water pH=10.5; Product distribution / selectivity;
88%
Stage #1: formaldehyd; 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester With formic acid In water at 81℃; for 5h;
Stage #2: With potassium hydroxide In tetrahydrofuran; water at 40℃; Product distribution / selectivity;
80.3%
4-bromo-2-fluoroaniline
367-24-8

4-bromo-2-fluoroaniline

4-chloro-6-methoxy-7-[(1'-methylpiperidin-4'-yl)methoxy]-quinazoline
264208-72-2

4-chloro-6-methoxy-7-[(1'-methylpiperidin-4'-yl)methoxy]-quinazoline

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
In isopropyl alcohol at 80℃; for 0.533333h; Microwave irradiation;89%
formaldehyd
50-00-0

formaldehyd

N-Desmethylvandetanib
338992-12-4

N-Desmethylvandetanib

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
With sodium triacetoxyborohydride; acetic acid In methanol; dichloromethane; water at 20℃; for 2h;85%
Stage #1: formaldehyd; N-Desmethylvandetanib With formic acid at 95℃; for 4h;
Stage #2: With sodium hydroxide In water pH=11;
45%
With sodium cyanoborohydride In tetrahydrofuran; methanol at 18 - 25℃; for 1h; Product distribution / selectivity;
formic acid
64-18-6

formic acid

N-Desmethylvandetanib
338992-12-4

N-Desmethylvandetanib

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In methanol; dichloromethane at 20℃; for 2h;84%
formaldehyd
50-00-0

formaldehyd

formic acid
64-18-6

formic acid

4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester
338992-20-4

4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Stage #1: 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester With hydrogenchloride In methanol; water at 20℃;
Stage #2: formaldehyd; formic acid at 20℃;
78%
4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline hydrochloride

4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline hydrochloride

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water Product distribution / selectivity; Saturated solution;
4-bromo-2-fluoroaniline
367-24-8

4-bromo-2-fluoroaniline

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride / isopropyl alcohol / 2 h / Reflux
2: trifluoroacetic acid / 1 h / Reflux
3: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C
4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
5: sodium triacetoxyborohydride; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic acid / 1 h / 130 °C / Irradiation
2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C
View Scheme
7-benzyloxy-4-chloro-6-methoxyquinazoline
162364-72-9

7-benzyloxy-4-chloro-6-methoxyquinazoline

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride / isopropyl alcohol / 2 h / Reflux
2: trifluoroacetic acid / 1 h / Reflux
3: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C
4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
5: sodium triacetoxyborohydride; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C
View Scheme
4-(4-bromo-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline
196603-96-0

4-(4-bromo-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C
2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
3: sodium triacetoxyborohydride; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C
View Scheme
7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine hydrochloride
768350-54-5

7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine hydrochloride

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: trifluoroacetic acid / 1 h / Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C
3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
4: sodium triacetoxyborohydride; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C
View Scheme
(E)-N'-(5-benzyloxy-2-cyano-4-methoxyphenyl)-N,N-dimethylformimidamide

(E)-N'-(5-benzyloxy-2-cyano-4-methoxyphenyl)-N,N-dimethylformimidamide

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: trifluoroacetic acid / 0.75 h / 70 °C / Irradiation
2: caesium carbonate / acetonitrile / 3 h / Reflux
3: acetic acid / 1 h / 130 °C / Irradiation
4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
5: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C
View Scheme
(E)-N'-(2-cyano-5-hydroxy-4-methoxyphenyl)-N,N-dimethylformimidamide

(E)-N'-(2-cyano-5-hydroxy-4-methoxyphenyl)-N,N-dimethylformimidamide

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: caesium carbonate / acetonitrile / 3 h / Reflux
2: acetic acid / 1 h / 130 °C / Irradiation
3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
4: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C
View Scheme
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2: acetic anhydride; nitric acid
3: tert-butylamine hydrochloride; sodium dithionite; sodium hydrogencarbonate / dichloromethane; water / 2 h
4: 0.25 h / 90 °C / Irradiation
5: trifluoroacetic acid / 0.75 h / 70 °C / Irradiation
6: caesium carbonate / acetonitrile / 3 h / Reflux
7: acetic acid / 1 h / 130 °C / Irradiation
8: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
9: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetonitrile / 0.17 h / 20 °C
1.2: 5 h / Reflux
2.1: acetic acid; nitric acid / 2 h / Cooling with ice
3.1: palladium 10% on activated carbon; hydrogen / methanol / 2327.23 Torr
4.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C
6.1: hydrogenchloride / methanol; water / 20 °C
6.2: 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetonitrile / 0.17 h / 20 °C
1.2: 5 h / Reflux
2.1: acetic acid; nitric acid / 2 h / Cooling with ice
3.1: palladium 10% on activated carbon; hydrogen / methanol / 2327.23 Torr
4.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C
6.1: hydrogenchloride / methanol; water / 20 °C
6.2: 20 °C
View Scheme
4-(benzyloxy)-3-methoxybenzonitrile
52805-34-2

4-(benzyloxy)-3-methoxybenzonitrile

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: acetic anhydride; nitric acid
2: tert-butylamine hydrochloride; sodium dithionite; sodium hydrogencarbonate / dichloromethane; water / 2 h
3: 0.25 h / 90 °C / Irradiation
4: trifluoroacetic acid / 0.75 h / 70 °C / Irradiation
5: caesium carbonate / acetonitrile / 3 h / Reflux
6: acetic acid / 1 h / 130 °C / Irradiation
7: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
8: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: acetic acid; nitric acid / 2 h / Cooling with ice
2.1: palladium 10% on activated carbon; hydrogen / methanol / 2327.23 Torr
3.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C
5.1: hydrogenchloride / methanol; water / 20 °C
5.2: 20 °C
View Scheme
4-(benzyloxy)-5-methoxy-2-nitrobenzonitrile
385784-84-9

4-(benzyloxy)-5-methoxy-2-nitrobenzonitrile

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: tert-butylamine hydrochloride; sodium dithionite; sodium hydrogencarbonate / dichloromethane; water / 2 h
2: 0.25 h / 90 °C / Irradiation
3: trifluoroacetic acid / 0.75 h / 70 °C / Irradiation
4: caesium carbonate / acetonitrile / 3 h / Reflux
5: acetic acid / 1 h / 130 °C / Irradiation
6: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
7: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 2327.23 Torr
2.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C
4.1: hydrogenchloride / methanol; water / 20 °C
4.2: 20 °C
View Scheme
2-amino-4-(benzyloxy)-5-methoxybenzonitrile
385785-02-4

2-amino-4-(benzyloxy)-5-methoxybenzonitrile

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 0.25 h / 90 °C / Irradiation
2: trifluoroacetic acid / 0.75 h / 70 °C / Irradiation
3: caesium carbonate / acetonitrile / 3 h / Reflux
4: acetic acid / 1 h / 130 °C / Irradiation
5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
6: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol / 2 h / 20 °C
View Scheme
(E)-N,N'-bis(4-bromo-2-fluorophenyl)formamidine

(E)-N,N'-bis(4-bromo-2-fluorophenyl)formamidine

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C
3.1: hydrogenchloride / methanol; water / 20 °C
3.2: 20 °C
View Scheme
2-amino-4-hydroxy-5-methoxybenzonitrile

2-amino-4-hydroxy-5-methoxybenzonitrile

vandetanib
443913-73-3

vandetanib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C
3.1: hydrogenchloride / methanol; water / 20 °C
3.2: 20 °C
View Scheme
vandetanib
443913-73-3

vandetanib

butan-1-ol
71-36-3

butan-1-ol

C26H33FN4O3

C26H33FN4O3

Conditions
ConditionsYield
With copper(l) iodide; N1, N2-diphenethyloxalamide; sodium t-butanolate In 1,4-dioxane for 24h; Schlenk technique; Inert atmosphere; Molecular sieve; Heating;75%
5-[2-(1,3-dioxan-2-yl)ethyl]-1-aza-5-germabicyclo[3.3.3]undecane

5-[2-(1,3-dioxan-2-yl)ethyl]-1-aza-5-germabicyclo[3.3.3]undecane

vandetanib
443913-73-3

vandetanib

N-(4-(2-(1,3-dioxan-2-yl)ethyl)-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine

N-(4-(2-(1,3-dioxan-2-yl)ethyl)-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine

Conditions
ConditionsYield
With bis(3,5-bis(trifluoromethyl)phenyl)(2-(2,4,6-triisopropylphenyl)-1H-inden-3-yl)phosphine; bis(dibenzylideneacetone)-palladium(0) In acetonitrile at 120℃; for 16h; Inert atmosphere; Sealed tube;73%
vandetanib
443913-73-3

vandetanib

4-((4-bromo-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol

4-((4-bromo-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol

Conditions
ConditionsYield
With pyridine hydrochloride at 190 - 200℃; for 1.33333h;17%
vandetanib
443913-73-3

vandetanib

4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline monohydrate

4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline monohydrate

Conditions
ConditionsYield
With water In tetrahydrofuran at 20 - 50℃; for 28.333 - 292.333h; Product distribution / selectivity;
2,2’,2”-nitrilotris(ethane-2,1-diyl)tris(1H-imidazole-1-carboxylate)

2,2’,2”-nitrilotris(ethane-2,1-diyl)tris(1H-imidazole-1-carboxylate)

ethylenediamine
107-15-3

ethylenediamine

vandetanib
443913-73-3

vandetanib

diZD

diZD

Conditions
ConditionsYield
Stage #1: 2,2’,2”-nitrilotris(ethane-2,1-diyl)tris(1H-imidazole-1-carboxylate); vandetanib With triethylamine In dimethyl sulfoxide at 20℃;
Stage #2: ethylenediamine In dimethyl sulfoxide at 20℃; for 24h;
Stage #1: 2,2’,2”-nitrilotris(ethane-2,1-diyl)tris(1H-imidazole-1-carboxylate); vandetanib With triethylamine In dimethyl sulfoxide at 20℃;
Stage #2: ethylenediamine In dimethyl sulfoxide for 24h;
Stage #3: With trifluoroacetic acid In dimethyl sulfoxide

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