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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% 4-Hydroxy-3-methoxybenzonitrile 4421-08-3 Producer

Cas:4421-08-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Vanillonitrile

Cas:4421-08-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:4-Hydroxy-3-methoxybenzonitrile CAS:4421-08-3 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without

Manufacturer supply CAS 4421-08-3 with best quality

Cas:4421-08-3

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

4-Hydroxy-3-Methoxybenzon-Itrile CAS 4421-08-3

Cas:4421-08-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 4421-08-3 with best quality

Cas:4421-08-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Hydroxy-3-methoxybenzonitrle

Cas:4421-08-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzonitrile,4-hydroxy-3-methoxy-

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 4-Hydroxy-3-Methoxybenzonitrile CAS No.:4421-08-3 Molecule Formula:C8H7NO2 Molecule Weight:149.15 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality 4-Hydroxy-3-Methoxybenzonitrile on stock

Cas:4421-08-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

4-Hydroxy-3-methoxybenzonitrile Chemical Properties Melting point 85-87 °C (lit.) Boiling point 270.21°C (rough estimate) density 1.2517 (rough estimate) refractive index 1.5320 (estimate) pka 7.84±0.18(Predicted) CA

4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:1 Gram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Hydroxy-3-methoxybenzonitrile cas no. 4421-08-3 98%

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Greenutra Resource Inc

4-Hydroxy-3-methoxybenzonitrileAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hebei Quanhe Biotechnology Co. LTD

Hebei Tecxiang Chemical Co., Ltd. is an enterprise specializing in the research and development, production and trade of pharmaceutical intermediates, apis and chemical raw materials and formula technology. Our company has extensive experience in the

4-Hydroxy-3-Methoxybenzonitrile

Cas:4421-08-3

Min.Order:1 Kilogram

FOB Price: $10.0 / 30.0

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

4-Hydroxy-3-Methoxybenzonitrile

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

4-Hydroxy-3-methoxybenzonitrile cas 4421-08-3Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

4-Hydroxy-3-methoxybenzonitrile cas 4421-08-3

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low priceAppearance:beige crystalline powder Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changzhou Ansciep Chemical Co.,Ltd.

reagent grade ex stockAppearance:white or off-white crystalline powder Storage:Keep away of light,cool place Package:1L 5L 10L 25L bottle Application:pharma intermediate Transportation:by Fedex, ship or plane

4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home an

4-Hydroxy-3-methoxybenzonitrle manufacture

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:5g Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port

4-Hydroxy-3-Methoxybenzonitrile

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Hydroxy-3-Methoxybenzonitrile

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

4-Hydroxy-3-methoxybenzonitrile 4421-08-3

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

HWRK Chem

in store Package:100g Application:Organic Chemicals

4-Hydroxy-3-methoxybenzonitrile

Cas:4421-08-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

vanillin
121-33-5

vanillin

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With phenoxyamine hydrochloride In methanol; aq. phosphate buffer; water-d2 at 60℃; for 8h; pH=6.5;99%
With iron(III) chloride; hydroxylamine hydrochloride In N,N-dimethyl-formamide for 3h; Reagent/catalyst; Reflux;98%
With copper(II) oxide; hydroxylamine hydrochloride In neat (no solvent) for 0.0194444h; Mechanism; Reagent/catalyst; Microwave irradiation; Green chemistry;98%
vanillin oxime
2874-33-1

vanillin oxime

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With iron(III) chloride; silica gel In neat (no solvent) at 110℃; for 1.5h; Catalytic behavior; Concentration; Temperature; Green chemistry;98%
With silica gel for 0.0166667h; microwave irradiation;95%
With hydroxylamine hydrochloride; phosphorus pentoxide; silica gel for 0.0166667h; microwave irradiation;95%
vanillin oxime hydrochloride

vanillin oxime hydrochloride

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
at 100℃; for 8h; Beckmann rearrangement;92%
potassiumhexacyanoferrate(II) trihydrate

potassiumhexacyanoferrate(II) trihydrate

2-methoxy-4-iodophenol
203861-62-5

2-methoxy-4-iodophenol

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With tetrabutylammomium bromide; copper(II) acetate monohydrate In water at 180℃; for 22h;86%
2-methoxy-4-iodophenol
203861-62-5

2-methoxy-4-iodophenol

potassium ferrocyanide

potassium ferrocyanide

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 130℃; for 10h; Schlenk technique;86%
veratronitrile
2024-83-1

veratronitrile

A

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

B

2-methoxy-5-cyanophenol
52805-46-6

2-methoxy-5-cyanophenol

Conditions
ConditionsYield
With sodium methylate; 1-dodecylthiol In N,N-dimethyl-formamide at 100℃; for 1h;A 83%
B 17%
Vanillylamin
1196-92-5

Vanillylamin

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With ammonium hydroxide; oxygen In tert-Amyl alcohol at 110℃; under 2250.23 Torr; for 15h; Autoclave; Green chemistry;83%
(E)-4-hydroxy-3-methoxybenzaldehyde oxime
134283-49-1

(E)-4-hydroxy-3-methoxybenzaldehyde oxime

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
at 120℃; for 2.5h; Beckmann rearrangement; Heating;73%
2-(2-methoxy-4-cyanophenoxy)-acetic acid
115109-49-4

2-(2-methoxy-4-cyanophenoxy)-acetic acid

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
Stage #1: 2-(2-methoxy-4-cyanophenoxy)-acetic acid With triethylamine In N,N-dimethyl-formamide; toluene for 3h; Curtius rearrangement; Heating;
Stage #2: With potassium hydroxide; glycerol In ethanol; N,N-dimethyl-formamide; toluene for 2h; Heating; Further stages.;
70%
methyl 3,4-dimethoxybenzoate
2150-38-1

methyl 3,4-dimethoxybenzoate

A

3,4-dihydroxybenzonitrile
17345-61-8

3,4-dihydroxybenzonitrile

B

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran at 185℃; for 24h;A 63%
B 23%
Homovanillic acid
306-08-1

Homovanillic acid

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With iron(III) trifluoromethanesulfonate; sodium nitrite In dimethyl sulfoxide at 50℃; for 10h; Inert atmosphere; Sealed tube;62%
potassium hexacyanoferrate(II) trihydrate

potassium hexacyanoferrate(II) trihydrate

2-methoxy-4-iodophenol
203861-62-5

2-methoxy-4-iodophenol

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With tetrabutylammomium bromide; copper(II) acetate monohydrate In water at 20 - 140℃; Microwave irradiation;59%
methyl 3,4-dimethoxybenzoate
2150-38-1

methyl 3,4-dimethoxybenzoate

A

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

B

2-methoxy-5-cyanophenol
52805-46-6

2-methoxy-5-cyanophenol

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran at 110℃; for 24h;A 55%
B 18%
veratronitrile
2024-83-1

veratronitrile

A

3,4-dihydroxybenzonitrile
17345-61-8

3,4-dihydroxybenzonitrile

B

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With 1,3-dimethyl-2-imidazolidinone; sodium hexamethyldisilazane In tetrahydrofuran at 185℃; for 12h; further reagent: LDA;A 53%
B 28%
4-bromoguaiacol
7368-78-7

4-bromoguaiacol

P-toluenesulfonyl cyanide
19158-51-1

P-toluenesulfonyl cyanide

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
Stage #1: 4-bromoguaiacol; P-toluenesulfonyl cyanide With potassium phosphate; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile In acetone for 0.25h; Inert atmosphere; Sealed tube;
Stage #2: With 1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)-2-trisilanol In acetone for 12h; Inert atmosphere; Irradiation;
41%
4-cyano-2-methoxyphenyl acetate
28335-42-4

4-cyano-2-methoxyphenyl acetate

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With potassium hydroxide
With hydrogenchloride
With potassium hydroxide In ethanol for 0.333333h; Heating; Yield given;
4-(benzyloxy)-3-methoxybenzonitrile
52805-34-2

4-(benzyloxy)-3-methoxybenzonitrile

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal
sulfuric acid
7664-93-9

sulfuric acid

vanillin
121-33-5

vanillin

NaN3

NaN3

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

copper cyanide

copper cyanide

diazotized 4-amino-pyrocatechol-2-methyl ether

diazotized 4-amino-pyrocatechol-2-methyl ether

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

3-methoxy-4-picryloxy-benzaldehyde-(O-picryl-seqtrans-oxime )

3-methoxy-4-picryloxy-benzaldehyde-(O-picryl-seqtrans-oxime )

alcoholic KOH-solution

alcoholic KOH-solution

A

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

B

2,4,6-Trinitrophenol
88-89-1

2,4,6-Trinitrophenol

vanillin
121-33-5

vanillin

A

vanillin oxime
2874-33-1

vanillin oxime

B

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With hydroxylamine hydrochloride; FeOO280 In toluene for 6h; Condensation; dehydration; Heating;A 43 % Chromat.
B 57 % Chromat.
With hydroxylamine hydrochloride; titanium(IV) oxide for 0.00833333h; Microwave irradiation; Neat (no solvent);
vanillin
121-33-5

vanillin

5-fluoro-2-trifluoromethylbenzyl halide

5-fluoro-2-trifluoromethylbenzyl halide

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (NH2OH)2*H2SO4; sodium acetate / ethanol / Heating
2: SOCl2 / benzene / Heating
View Scheme
Multi-step reaction with 2 steps
1: 89 percent / aq. NaOH; hydroxylamine hydrochloride / ethanol / 0 - 20 °C
2: 85 percent / phthalic anhydride / 0.08 h / Heating
View Scheme
vanillin
121-33-5

vanillin

iron (II)-chloride

iron (II)-chloride

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NH2OH*HCl; Et3N / CHCl3 / 0 - 20 °C
2: bis(trichloromethyl) carbonate / CHCl3 / 20 °C
View Scheme
3-methoxy-4-(phenylmethoxy)benzaldehyde
2426-87-1

3-methoxy-4-(phenylmethoxy)benzaldehyde

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) NH2OH*HCl, Py, (ii) DCC, CuSO4*5H2O, Et3N
2: H2 / Pd-C
View Scheme
pentahydrated cupric sulfate

pentahydrated cupric sulfate

(4-hydroxy-3-methoxy-phenyl)-glyoxylic acid
2021-40-1

(4-hydroxy-3-methoxy-phenyl)-glyoxylic acid

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
With sodium hydroxide; ammonia In water
4-(hydrazonomethyl)-2-methoxyphenol
1527-84-0

4-(hydrazonomethyl)-2-methoxyphenol

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: laccase from Trametesversicolor; oxygen / dimethyl sulfoxide / 16 h / 30 °C / pH 4.7 / Enzymatic reaction
2: hydroxylamine hydrochloride / acetonitrile / 4 h / Reflux
View Scheme
4-((2-(1H-tetrazol-5-yl)hydrazono)methyl)-2-methoxyphenol
56929-45-4

4-((2-(1H-tetrazol-5-yl)hydrazono)methyl)-2-methoxyphenol

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: laccase from Trametesversicolor; oxygen / ethanol / 2 h / 30 °C / pH 4.7 / Enzymatic reaction
2: hydroxylamine hydrochloride / acetonitrile / 4 h / Reflux
View Scheme
4-bromoguaiacol
7368-78-7

4-bromoguaiacol

copper(l) cyanide

copper(l) cyanide

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide
2-methoxy-phenol
90-05-1

2-methoxy-phenol

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-Bromosuccinimide
2: N,N-dimethyl-formamide
View Scheme
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

2-methoxy-4-(2H-tetrazol-5-yl)-phenol

2-methoxy-4-(2H-tetrazol-5-yl)-phenol

Conditions
ConditionsYield
With sodium azide; zinc dibromide In water; isopropyl alcohol at 80℃; for 24h;100%
With ammonium azide; ammonium chloride; lithium chloride In N,N-dimethyl-formamide at 120 - 130℃; for 24h;40%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

benzyl bromide
100-39-0

benzyl bromide

4-(benzyloxy)-3-methoxybenzonitrile
52805-34-2

4-(benzyloxy)-3-methoxybenzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;100%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 18h;100%
Stage #1: 3-methoxy-4-hydroxybenzonitrile With potassium carbonate In acetonitrile at 20℃; for 0.166667h;
Stage #2: benzyl bromide In acetonitrile for 5h; Reflux;
96.8%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

4-(tert-butyldimethylsilyloxy)-3-methoxybenzonitrile
1245744-72-2

4-(tert-butyldimethylsilyloxy)-3-methoxybenzonitrile

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane at 20℃; for 2h; Inert atmosphere;100%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

dimethylamino sulfonyl chloride
13360-57-1

dimethylamino sulfonyl chloride

4-cyano-2-methoxyphenyl N,N-dimethylsulfamate
1432739-31-5

4-cyano-2-methoxyphenyl N,N-dimethylsulfamate

Conditions
ConditionsYield
Stage #1: 3-methoxy-4-hydroxybenzonitrile With dmap; triethylamine In dichloromethane at 20℃; for 0.166667h;
Stage #2: dimethylamino sulfonyl chloride In dichloromethane at 20℃; for 16h;
100%
ethyl bromide
74-96-4

ethyl bromide

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

4-ethoxy-3-methoxybenzonitrile
81259-56-5

4-ethoxy-3-methoxybenzonitrile

Conditions
ConditionsYield
Stage #1: 3-methoxy-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.583333h;
Stage #2: ethyl bromide In N,N-dimethyl-formamide at 0 - 20℃;
100%
With potassium carbonate In acetone Reflux;
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

6,6'-dihydroxy-5,5'-dimethoxy-[1,1'-biphenyl]-3,3'-dicarbonitrile

6,6'-dihydroxy-5,5'-dimethoxy-[1,1'-biphenyl]-3,3'-dicarbonitrile

Conditions
ConditionsYield
With laccase from Trametesversicolor; oxygen In aq. acetate buffer at 30℃; for 2h; pH=4.7; Reagent/catalyst; Enzymatic reaction;99%
With laccase from Trametes versicolor; oxygen In acetone at 20℃; for 24h; pH=5; Green chemistry; Enzymatic reaction;95%
With laccase from Trametes versicolor; oxygen In acetone at 20℃; for 24h; pH=5; Enzymatic reaction;95%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

4-bromomethyltrifluoromethylbenzene
402-49-3

4-bromomethyltrifluoromethylbenzene

3-methoxy-4-((4-(trifluoromethyl)benzyl)oxy)benzonitrile

3-methoxy-4-((4-(trifluoromethyl)benzyl)oxy)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 80℃; Williamson Ether Synthesis; Inert atmosphere;99%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

3-methoxy-4-O-trifluoromethylsulfonylbenzonitrile
652997-57-4

3-methoxy-4-O-trifluoromethylsulfonylbenzonitrile

Conditions
ConditionsYield
With triethylamine In dichloromethane at -78 - 20℃; for 14h; Inert atmosphere;98.4%
With pyridine at 20 - 25℃;92%
With pyridine at 20 - 25℃; for 1h;92%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

ethyl iodide
75-03-6

ethyl iodide

4-ethoxy-3-methoxybenzonitrile
81259-56-5

4-ethoxy-3-methoxybenzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 40℃; for 16h;98%
With potassium hydroxide
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

3,4-dihydroxybenzonitrile
17345-61-8

3,4-dihydroxybenzonitrile

Conditions
ConditionsYield
With aluminium(III) iodide; diisopropyl-carbodiimide In acetonitrile at 80℃; for 18h;98%
With aluminium(III) iodide; calcium oxide In acetonitrile at 80℃; for 18h;95%
With aluminium(III) iodide In dimethyl sulfoxide; acetonitrile at 80℃; for 18h;95%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

mechlorethamine hydrochloride
55-86-7

mechlorethamine hydrochloride

1,5-bis(4-cyano-2-methoxyphenoxy)-N-methyl-3-azapentane
1357621-02-3

1,5-bis(4-cyano-2-methoxyphenoxy)-N-methyl-3-azapentane

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 115℃; for 3h;98%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

3-(bromomethyl)benzonitrile
28188-41-2

3-(bromomethyl)benzonitrile

3-cyanobenzyl 4-cyano-2-methoxyphenyl ether
923831-00-9

3-cyanobenzyl 4-cyano-2-methoxyphenyl ether

Conditions
ConditionsYield
Stage #1: 3-methoxy-4-hydroxybenzonitrile With potassium carbonate In N,N-dimethyl-formamide for 0.5h;
Stage #2: m-(bromomethyl)benzonitrile In N,N-dimethyl-formamide
98%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

2-(chloromethyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole
350672-14-9

2-(chloromethyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole

4-((5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)methoxy)-3-methoxybenzonitrile

4-((5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)methoxy)-3-methoxybenzonitrile

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 20℃;98%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

benzyl chloride
100-44-7

benzyl chloride

4-(benzyloxy)-3-methoxybenzonitrile
52805-34-2

4-(benzyloxy)-3-methoxybenzonitrile

Conditions
ConditionsYield
Stage #1: 3-methoxy-4-hydroxybenzonitrile With potassium carbonate In acetonitrile at 20℃; for 0.166667h;
Stage #2: benzyl chloride In acetonitrile for 5h; Reflux;
95.7%
With potassium carbonate In acetone88%
2-iodo-propane
75-30-9

2-iodo-propane

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

4-isopropoxy-3-methoxybenzonitrile
757192-64-6

4-isopropoxy-3-methoxybenzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetone for 22h; Reflux;95%
With potassium carbonate In acetone for 22h; Reflux;
CH3O3S(1-)*C11H19N2O(1+)

CH3O3S(1-)*C11H19N2O(1+)

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

3-methoxy-4-(4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyloxy)benzonitrile
1319736-49-6

3-methoxy-4-(4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyloxy)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide at 120℃; for 3h;94%
spiro[7-azoniabicyclo[2,2,1]heptane-7,4'-[1'-methyl-2'-oxo-4'-piperazinium]methanesulphonate]
1207726-33-7

spiro[7-azoniabicyclo[2,2,1]heptane-7,4'-[1'-methyl-2'-oxo-4'-piperazinium]methanesulphonate]

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

3-methoxy-4-(4-(4-methyl-3-oxo-piperazine-1-yl)cyclohexyloxy)benzonitrile

3-methoxy-4-(4-(4-methyl-3-oxo-piperazine-1-yl)cyclohexyloxy)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In ISOPROPYLAMIDE at 120℃; for 3h;94%
1-chloro-4-pentyne
14267-92-6

1-chloro-4-pentyne

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

3-methoxy-4-(pent-4-yn-1-yloxy)benzonitrile

3-methoxy-4-(pent-4-yn-1-yloxy)benzonitrile

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In 1-methyl-pyrrolidin-2-one at 65℃; for 24h;93%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

3-methoxy-4-(methoxymethyloxy)benzonitrile
161196-85-6

3-methoxy-4-(methoxymethyloxy)benzonitrile

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 3h;92%
With N-ethyl-N,N-diisopropylamine In dichloromethane80%
1,1'-(Azodicarbonyl)dipiperidin
10465-81-3

1,1'-(Azodicarbonyl)dipiperidin

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

4-(4-chlorophenyl)-5-(3-hydroxypropyl)-2-(2-methylimidazol-1-yl)oxazole
198064-22-1

4-(4-chlorophenyl)-5-(3-hydroxypropyl)-2-(2-methylimidazol-1-yl)oxazole

4-(4-chlorophenyl)-5-[3-(4-cyano-2-methoxyphenoxy)propyl]-2-(2-methyl-1-imidazolyl)oxazole
327189-33-3

4-(4-chlorophenyl)-5-[3-(4-cyano-2-methoxyphenoxy)propyl]-2-(2-methyl-1-imidazolyl)oxazole

Conditions
ConditionsYield
With tributylphosphine In tetrahydrofuran92%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

trifluoromethanesulfonic acid anhydride
1025373-45-8

trifluoromethanesulfonic acid anhydride

3-methoxy-4-O-trifluoromethylsulfonylbenzonitrile
652997-57-4

3-methoxy-4-O-trifluoromethylsulfonylbenzonitrile

Conditions
ConditionsYield
With pyridine at 0 - 25℃;92%
1-bromo-butane
109-65-9

1-bromo-butane

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

3-methoxy-4-butoxybenzonitrile

3-methoxy-4-butoxybenzonitrile

Conditions
ConditionsYield
Stage #1: 3-methoxy-4-hydroxybenzonitrile With potassium carbonate In water; N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: 1-bromo-butane In water; N,N-dimethyl-formamide at 20 - 37℃;
92%
Stage #1: 3-methoxy-4-hydroxybenzonitrile With potassium carbonate In water; N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: 1-bromo-butane In water; N,N-dimethyl-formamide at 20 - 37℃;
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

2-(chloromethyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole
24023-71-0

2-(chloromethyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole

3-methoxy-4-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methoxy)benzonitrile

3-methoxy-4-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methoxy)benzonitrile

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 20℃;92%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

ethyl halide

ethyl halide

4-ethoxy-3-methoxybenzonitrile
81259-56-5

4-ethoxy-3-methoxybenzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 37℃;91.8%
styrene
292638-84-7

styrene

methanol
67-56-1

methanol

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

(1S*,4R*,7R*)-6,6-dimethoxy-5-oxo-8-phenylbicyclo[2.2.2]oct-2-en-2-yl cyanide

(1S*,4R*,7R*)-6,6-dimethoxy-5-oxo-8-phenylbicyclo[2.2.2]oct-2-en-2-yl cyanide

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene at 50℃; for 1h; Oxidation; Diels-Alder cycloaddition;91%
With [bis(acetoxy)iodo]benzene at 50℃; for 4h; Diels-Alder reaction;91%
triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

3-methoxy-4-(triisopropylsilyloxy)benzonitrile
222622-85-7

3-methoxy-4-(triisopropylsilyloxy)benzonitrile

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;91%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; Inert atmosphere;91%
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

acetyl chloride
75-36-5

acetyl chloride

4-cyano-2-methoxyphenyl acetate
28335-42-4

4-cyano-2-methoxyphenyl acetate

Conditions
ConditionsYield
With pyridine In tetrahydrofuran at 20℃; for 2h;91%

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