CAS No.55-86-7,Chlormethine hydrochloride Suppliers

Hunan Russell Chemicals Technology Co.,Ltd

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Mechlorethamine Hydrochloride 55-86-7

Cas:55-86-7

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Pure Chemistry Scientific Inc.

Mechlorethamine Hydrochloride Application:80080091

Mechlorethamine Hydrochloride

Cas:55-86-7

Min.Order:1 Gram

FOB Price: $500.0

Type:Trading Company

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Synthetic route

: 50-00-0
formaldehyd

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 55-86-7
mechlorethamine hydrochloride

Conditions

Conditions	Yield
With formic acid at 100 - 120℃; for 3.33333h;	100%
With formic acid In water at 100 - 120℃; for 3.33333h; Heating / reflux;	100%
With formic acid In water at 100 - 120℃; for 3.33333h;	100%
With formic acid In water 1a.) 100 deg C, 3 h, 1b.) 120 deg C, 20 min; Yield given;

: 54060-15-0
2-[2-hydroxyethyl(methyl)amino]ethanol hydrochloride

: 55-86-7
mechlorethamine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In chloroform for 2h; Chlorination; Heating;	99%

: 50-00-0
formaldehyd

: 64-18-6
formic acid

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 55-86-7
mechlorethamine hydrochloride

Conditions

Conditions	Yield
In water at 100℃; for 3h; Reflux;	99%

...Expand

: 105-59-9
N-Methyldiethanolamine

: 55-86-7
mechlorethamine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In chloroform at 20℃; for 2h;	96%
With thionyl chloride In dichloromethane at 0 - 20℃; for 24h;	92%
With thionyl chloride In dichloromethane at 20℃; for 48h; Cooling with ice;	85%

: 64-18-6
formic acid

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 55-86-7
mechlorethamine hydrochloride

Conditions

Conditions	Yield
In water at 100 - 120℃;	92%

: 55-86-7
mechlorethamine hydrochloride

: 104-47-2
p-methoxybenzylnitrile

: 487013-52-5
4-(4-methoxyphenyl)-1-methylpiperidine-4-carbonitrile

Conditions

Conditions	Yield
With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 60℃; for 24h;	100%
With tetra(n-butyl)ammonium hydrogensulfate In sodium hydroxide	20%

: 55-86-7
mechlorethamine hydrochloride

: 4-(n-butoxy-benzenesulfonyl) acetic acid ethyl ester

: 239797-38-7
1-methyl-4-(4-butoxybenzenesulfonyl)piperidine-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In acetone for 16h; Heating;	98%

: 4421-08-3
3-methoxy-4-hydroxybenzonitrile

: 55-86-7
mechlorethamine hydrochloride

: 1357621-02-3
1,5-bis(4-cyano-2-methoxyphenoxy)-N-methyl-3-azapentane

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 115℃; for 3h;	98%

: 10025-99-7
potassium tetrachloroplatinate(II)

: 55-86-7
mechlorethamine hydrochloride

: 2-chloro-N-(2-chloroethyl)-N-methylethylammonium tetrachloroplatinate(II)

Conditions

Conditions	Yield
In water aq. soln. mechlorethamine hydrochloride and K2PtCl4 was heated at 50-60°C for 3 h; soln. was left at room temp. for 2 days, ppt. was filtered off, washed with EtOH and air-dried; elem. anal.;	95%

: 55-86-7
mechlorethamine hydrochloride

: 140-53-4
p-chlorobenzyl cyanide

: 258500-81-1
4-(4-chlorophenyl)-1-methylpiperidine-4-carbonitrile

Conditions

Conditions	Yield
With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 60℃; for 24h;	92%
With tetra(n-butyl)ammonium hydrogensulfate In sodium hydroxide

: 16532-79-9
4-Bromophenylacetonitrile

: 55-86-7
mechlorethamine hydrochloride

: 1225452-44-7
4-(4-bromophenyl)-1-methylpiperidine-4-carbonitrile

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20 - 60℃; for 19h;	90%

: 55-86-7
mechlorethamine hydrochloride

: 17356-08-0
thiourea

: 63915-53-7, 111012-88-5
bis-(2-carbamimidoylmercapto-ethyl)-methyl-amine; trihydrochloride

Conditions

Conditions	Yield
In ethanol for 5h; Condensation; Heating;	88%
In ethanol at 80℃; for 5h;	65%
In ethanol Reflux;

: 55-86-7
mechlorethamine hydrochloride

: 6928-85-4
N-amino-N'-methylpiperazine

Conditions

Conditions	Yield
With hydrazine hydrate	87%

: 55-86-7
mechlorethamine hydrochloride

A: N,N-bis(2-hydrazinoethyl)methylamine

B: 6928-85-4
N-amino-N'-methylpiperazine

Conditions

Conditions	Yield
With hydrazine hydrate at 50℃; for 2h;	A 2% B 87%

: 459-22-3
4-fluorophenylacetonitrile

: 55-86-7
mechlorethamine hydrochloride

: 258500-80-0
4-(4-fluorophenyl)-1-methylpiperidine-4-carbonitrile

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 60℃; for 24h;	82%
With sodium hydride In DMF (N,N-dimethyl-formamide) at 60℃; for 24h;	82%
With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 60℃; for 24h;	82%
With tetra(n-butyl)ammonium hydrogensulfate In sodium hydroxide

: 55-86-7
mechlorethamine hydrochloride

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 258500-84-4
4-(3,4-dichlorophenyl)-1-methylpiperidine-4-carbonitrile

Conditions

Conditions	Yield
With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 60℃; for 24h;	82%
With sodium hydroxide; cetyltributylphosphonium bromide at 100℃; for 1h;
With sodium hydroxide; tributyl pentadecylphosphonium bromide In water at 100℃; for 1h;

: 55-86-7
mechlorethamine hydrochloride

: 767-00-0
4-cyanophenol

: 1030364-10-3
4,4'-[1,5-(N-methyl-3-azapentanediylbis(oxy))]bisbenzonitrile

Conditions

Conditions	Yield
With potassium carbonate In various solvent(s) at 130℃; for 16h;	82%

: 55-86-7
mechlorethamine hydrochloride

: 99365-40-9
6-bromo-2,3-dihydro-1H-indole-2-one

: 1160248-46-3
6-bromo-1'-methyl-spiro [indole-3,4'-piperidin]-2 (1H)-one

Conditions

Conditions	Yield
Stage #1: 6-bromo-2,3-dihydro-1H-indole-2-one With sodium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Stage #2: mechlorethamine hydrochloride In tetrahydrofuran at -78 - 20℃; for 48.5h;	82%
Stage #1: 6-bromo-2,3-dihydro-1H-indole-2-one With sodium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Stage #2: mechlorethamine hydrochloride In tetrahydrofuran at -78 - 20℃;	31%

: 55-86-7
mechlorethamine hydrochloride

: 239796-74-8
[4-(4-chlorophenoxy)benzenesulfonyl]acetic acid ethyl ester

: 239797-42-3
4-[4-(4-chlorophenoxy)benzenesulfonyl]-1-methylpiperidine-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In acetone for 16h; Heating;	81%

: 20870-78-4
5-bromo-2-indolin-2-one

: 55-86-7
mechlorethamine hydrochloride

: 920023-48-9
5-bromo-1'-methyl-spiro[indoline-3,4'-piperidine]-2-one

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-indolin-2-one With sodium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Stage #2: mechlorethamine hydrochloride In tetrahydrofuran at -78 - 20℃; for 48.5h;	78%

: 70127-50-3
diphenyl(2-hydroxyphenylmethyl)phosphine oxide

: 55-86-7
mechlorethamine hydrochloride

: 209346-62-3
methylamine

Conditions

Conditions	Yield
With caesium carbonate In 1,4-dioxane for 14h; Heating;	76%

: 2850-21-7
2-(4-methoxybenzenesulfonyl)acetic acid ethyl ester

: 55-86-7
mechlorethamine hydrochloride

: 212770-92-8
1-methyl-4-(4-methoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In acetone for 16h; Heating;	75%

: 72684-95-8
3,5-dimethoxy-4-hydroxybenzonitrile

: 55-86-7
mechlorethamine hydrochloride

: 1357621-03-4
1,5-bis(4-cyano-2,6-dimethoxyphenoxy)-N-methyl-3-azapentane

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 80℃; for 1.5h;	74%

: 20491-53-6
di-isopropylphosphine

: 55-86-7
mechlorethamine hydrochloride

: 2-(diisopropylphosphanyl)-N-(2-(diisopropylphosphanyl)ethyl)-N-methylethan-1-amine

Conditions

Conditions	Yield
Stage #1: di-isopropylphosphine With n-butyllithium In tetrahydrofuran for 1h; Schlenk technique; Reflux; Stage #2: mechlorethamine hydrochloride With n-butyllithium In tetrahydrofuran Schlenk technique; Reflux;	73%
Stage #1: di-isopropylphosphine With n-butyllithium In diethyl ether; hexane at -78℃; for 4h; Schlenk technique; Reflux; Inert atmosphere; Stage #2: mechlorethamine hydrochloride With n-butyllithium In diethyl ether; hexane at -78℃; for 2h; Schlenk technique; Inert atmosphere; Reflux;

: 95-56-7
2-hydroxybromobenzene

: 55-86-7
mechlorethamine hydrochloride

: 94896-98-7
N-methylbis<2-(o-bromophenoxy)ethyl>amine

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 3h; Heating;	72%

: 5367-60-2
3-nitro-(4-piperidin-1-yl)aniline

: 55-86-7
mechlorethamine hydrochloride

: 885704-45-0
1-methyl-4-(3-nitro-4-piperidin-1-yl-phenyl)-piperazine

Conditions

Conditions	Yield
With potassium carbonate In ethanol for 48h;	71%

: 19966-86-0
lithium di-tert-butylphosphide

: 55-86-7
mechlorethamine hydrochloride

: 1086138-37-5
bis(2-(di-t-butylphosphino)ethyl)methylamine

Conditions

Conditions	Yield
Stage #1: mechlorethamine hydrochloride With n-butyllithium In diethyl ether; hexane at -78 - 20℃; for 2h; Inert atmosphere; Schlenk technique; Stage #2: lithium di-tert-butylphosphide In diethyl ether; hexane at -78 - 60℃; Inert atmosphere; Schlenk technique; Reflux;	69%
Stage #1: mechlorethamine hydrochloride With n-butyllithium In tetrahydrofuran; hexane at 0℃; Inert atmosphere; Schlenk technique; Stage #2: lithium di-tert-butylphosphide In tetrahydrofuran; hexane at -78℃; Inert atmosphere; Schlenk technique;	3.8 g

: 55-86-7
mechlorethamine hydrochloride

: 829-85-6
diphenylphosphane

: 200885-37-6
N-methyl (bis(2-(diphenylphosphanyl)ethyl))amine

Conditions

Conditions	Yield
Stage #1: diphenylphosphane With n-butyllithium In tetrahydrofuran; hexane Stage #2: mechlorethamine hydrochloride With n-butyllithium In tetrahydrofuran	68%
Stage #1: diphenylphosphane With n-butyllithium In diethyl ether; hexane at -78℃; for 4h; Inert atmosphere; Schlenk technique; Reflux; Stage #2: mechlorethamine hydrochloride In diethyl ether; hexane at -78℃; Inert atmosphere; Schlenk technique; Reflux;	0.6538 g

: (R)-5-amino-3-N,N-dibenzylamino-3,4-dihydro-2H-1-benzopyran

: 55-86-7
mechlorethamine hydrochloride

: (R)-3-N,N-dibenzylamino-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-1-benzopyran

Conditions

Conditions	Yield
With sodium hydroxide; sodium iodide; sodium hydrogencarbonate In water; acetonitrile	67%

: 55-86-7
mechlorethamine hydrochloride

: 61394-49-8
ethyl 2-oxindoline-5-carboxylate

: 946135-53-1
ethyl 1'-methyl-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylate

Conditions

Conditions	Yield
Stage #1: ethyl 2-oxindoline-5-carboxylate With sodium hydride In N,N-dimethyl-formamide for 0.166667h; cooling; Stage #2: mechlorethamine hydrochloride In N,N-dimethyl-formamide for 5.16667h; Further stages.;	65%

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CAS No.:55-86-7
Name:Chlormethine hydrochloride
Article Data:21
Molecular Structure:
Formula:C₅H₁₁Cl₂N . Cl H
Molecular Weight:192.516
Synonyms:Diethylamine,2,2'-dichloro-N-methyl-, hydrochloride (8CI);Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-,hydrochloride (9CI);1,5-Dichloro-3-methyl-3-azapentane hydrochloride;2,2'-Dichloro-N-methyldiethylamine hydrochloride;Antimit;Azotoyperite;Bis(2-chloroethyl)-N-methylamine hydrochloride;C 6866;Caryolysine;Caryolysine hydrochloride;Chloramin;Chloramin hydrochloride;Chloramine;Chlorethamine;Chlormethine hydrochloride;Chlormethinum;Dema;Dichloren;Dichloren hydrochloride;Dichloromethyldiethylamine hydrochloride;Dimitan;Embechine;Embichin;Embichin hydrochloride;Embikhine;Embiquine;Erasol;Erasol hydrochloride;Erasol-Ido;HN2 hydrochloride;Kloramin;MBA hydrochloride;Mechlorethaminehydrochloride;Methylbis(2-chloroethyl)amine hydrochloride;Methylbis(b-chloroethyl)amine hydrochloride;Mitoxine;Mustargen hydrochloride;Mustine hydrochloride;N,N-Bis(2-chloroethyl)methanamine hydrochloride;N-Lost;N-Methyl-N,N-bis(2-chloroethyl)amine hydrochloride;N-Methylbis(2-chloroethyl)amine hydrochloride;NCI C56382;NM;NSC 762;NSC 762hydrochloride;Nitol;Nitol takeda;Nitrogen mustard;Nitrogen mustard (HN 2)hydrochloride;Nitrogen mustard hydrochloride;Nitrogranulogen;Nitrogranulogenhydrochloride;SK 101;
EINECS:200-246-0
Density:1.106g/cm³
Melting Point:108-111 °C(lit.)
Boiling Point:110.3°C at 760 mmHg
Flash Point:20.5°C
Solubility:
Appearance:white crystalline powder
Hazard Symbols:
Risk Codes45-46-28-34-42/43
Safety: 53-36/37/39-45
Transport Information:UN 2811
PSA:3.24000
LogP:2.19780

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