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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-Bromo-5-fluoroanisole Manufacturer/High quality/Best price/In stock

Cas:450-88-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Bromo-5-Fluoroanisole with high purity

Cas:450-88-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:shanghai

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 450-88-4 with competitive price

Cas:450-88-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzene,1-bromo-4-fluoro-2-methoxy- 450-88-4

Cas:450-88-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Bromo-5-Fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzene,1-bromo-4-fluoro-2-methoxy-

Cas:450-88-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

BUTTPARK 87\07-62; 2-BROMO-5-FLUOROANISOLE; 1-Bromo-4-fluoro-2-methoxybenzene; 2-Bromo-5-fluoroanisole98+%; 1-Bromo-4-fluoro-2-methoxybenzene, 2- Bromo-5-fluorophenyl methyl ether; 2-BroMo-5-fluoroanisole, 95.0% (GC) CAS No.: 450-88-4 Molecular

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2-Bromo-5-Fluoroanisole CAS No.:450-88-4 Molecule Formula:C7H6BrFO Molecule Weight:205.02 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING IT

High Quality 2-Bromo-5-Fluoroanisole on stock

Cas:450-88-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

2-Bromo-5-fluoroanisoleCAS NO.: 450-88-4

Cas:450-88-4

Min.Order:1 Kilogram

FOB Price: $4.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 2-Bromo-5-fluoroanisole Synonyms: 2-BroMo-5-fluoroanisole, 95.0%(GC);1-Bromo-4-fluoro-2-methoxybenzene, 2-Bromo-5-fluorophenyl methyl ether;BUTTPARK 87\07-62;2-BROMO-5-FLUOROANISOLE;1-Bromo-4-fluoro-2-methoxybenzene;2-Bromo-5-fluo

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Changzhou Anchor Biological Technology Co., Ltd.

Our company is engaged in customizing the benzene ring and pyridine derivative organic intermediates, and the quantity is flexible according to customer's needs. It mainly provides high-quality intermediates for domestic and foreign pharmaceutical an

2-Bromo-5-fluoroanisole Manufacturer/High quality/Best price/In stock CAS NO.450-88-4

Cas:450-88-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Bromo-5-Fluoroanisole cas no. 450-88-4 98%

Cas:450-88-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

2-BroMo-5-fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer Answer: Yes, we are factory founded on 2012.Q2: How to contact with us Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours.Q3:Which kind of payment terms do you

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

2-Bromo-5-Fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city?in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api,?intermediat

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Grams, Kilograms Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-BroMo-5-fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Pharm intermediate

2-Bromo-5-fluoroanisole

Cas:450-88-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

dimethyl sulfate
77-78-1

dimethyl sulfate

2-bromo-5-fluorophenol
147460-41-1

2-bromo-5-fluorophenol

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
With potassium carbonate In acetone at 60℃; for 2h;100%
With potassium carbonate In acetone at 60℃; for 2h;100%
With potassium carbonate In acetone at 60℃; for 2h;100%
4-fluoro-2-methoxyaniline
450-91-9

4-fluoro-2-methoxyaniline

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
Stage #1: 4-fluoro-2-methoxyaniline With sodium nitrite In water at -5 - 0℃;
Stage #2: With hydrogen bromide; copper(I) bromide In water at 105℃;
93%
Diazotization;
2-bromo-5-fluorophenol
147460-41-1

2-bromo-5-fluorophenol

methyl iodide
74-88-4

methyl iodide

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;93%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 3h;
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 3h;
2,4-difluorobromobenzene
348-57-2

2,4-difluorobromobenzene

potassium methanolate
865-33-8

potassium methanolate

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
In tetrahydrofuran at 65 - 68℃; for 5h;93%
In tetrahydrofuran at 65 - 68℃; for 5h;93%
In tetrahydrofuran at 65℃; for 4h;90%
4-fluoro-2-methoxy-benzoic acid
395-82-4

4-fluoro-2-methoxy-benzoic acid

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
With potassium phosphate; tetrabuthylammonium tribromide In acetonitrile at 100℃; for 16h;75%
methanol
67-56-1

methanol

2,4-difluorobromobenzene
348-57-2

2,4-difluorobromobenzene

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
Stage #1: methanol With sodium hydride In tetrahydrofuran at 0℃; for 15h;
Stage #2: 2,4-difluorobromobenzene In tetrahydrofuran at 20℃; for 17h; Further stages.;
42%
2,4-difluorobromobenzene
348-57-2

2,4-difluorobromobenzene

potassium methanolate
865-33-8

potassium methanolate

A

1-Bromo-2,4-dimethoxybenzene
17715-69-4

1-Bromo-2,4-dimethoxybenzene

B

1-bromo-2-fluoro-4-methoxybenzene
458-50-4

1-bromo-2-fluoro-4-methoxybenzene

C

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
In tetrahydrofuran at 65 - 68℃; for 22h; Inert atmosphere; regioselective reaction;A 9%
B n/a
C n/a
1-fluoro-3-methoxybenzene
456-49-5

1-fluoro-3-methoxybenzene

A

1-bromo-2-fluoro-4-methoxybenzene
458-50-4

1-bromo-2-fluoro-4-methoxybenzene

B

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
With bromine; tetramethylammonium bromide In liquid sulphur dioxide at -23℃; Product distribution; Rate constant;
With bromine; iron In chloroform at -60℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
N-Formylpiperidine
2591-86-8

N-Formylpiperidine

1-fluoro-3-methoxybenzene
456-49-5

1-fluoro-3-methoxybenzene

A

2-fluoro-4-methoxy-benzaldehyde
331-64-6

2-fluoro-4-methoxy-benzaldehyde

B

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

C

2-methoxy-4-fluorobenzaldehyde
450-83-9

2-methoxy-4-fluorobenzaldehyde

Conditions
ConditionsYield
Yield given. Multistep reaction;
4-fluoro-2-methoxy-1-nitrobenzene
448-19-1

4-fluoro-2-methoxy-1-nitrobenzene

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: iron; aqueous acetic acid
2: Diazotization
View Scheme
Multi-step reaction with 2 steps
1.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 30 - 35 °C / 3750.38 - 7500.75 Torr / Autoclave; Inert atmosphere
2.1: sodium nitrite / water / -5 - 0 °C
2.2: 105 °C
View Scheme
methanol
67-56-1

methanol

2,4-difluorobromobenzene
348-57-2

2,4-difluorobromobenzene

A

1-bromo-2-fluoro-4-methoxybenzene
458-50-4

1-bromo-2-fluoro-4-methoxybenzene

B

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
With potassium tert-butylate In 1,4-dioxane at 20℃; Inert atmosphere; regioselective reaction;
2,4-difluorobromobenzene
348-57-2

2,4-difluorobromobenzene

potassium methanolate
865-33-8

potassium methanolate

A

1-bromo-2-fluoro-4-methoxybenzene
458-50-4

1-bromo-2-fluoro-4-methoxybenzene

B

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
With potassium tert-butylate In 1,4-dioxane at 20℃; for 24h; Inert atmosphere; regioselective reaction;
2,4-Difluoronitrobenzene
446-35-5

2,4-Difluoronitrobenzene

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium hydroxide / water; toluene / 55 - 60 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 60 - 100 °C
3.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 30 - 35 °C / 3750.38 - 7500.75 Torr / Autoclave; Inert atmosphere
4.1: sodium nitrite / water / -5 - 0 °C
4.2: 105 °C
View Scheme
5-fluoro-2-nitrophenol
446-36-6

5-fluoro-2-nitrophenol

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 60 - 100 °C
2.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 30 - 35 °C / 3750.38 - 7500.75 Torr / Autoclave; Inert atmosphere
3.1: sodium nitrite / water / -5 - 0 °C
3.2: 105 °C
View Scheme
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

acetyl chloride
75-36-5

acetyl chloride

1-(5-bromo-2-fluoro-4-methoxyphenyl)ethan-1-one
914221-54-8

1-(5-bromo-2-fluoro-4-methoxyphenyl)ethan-1-one

Conditions
ConditionsYield
With aluminum (III) chloride In 1,2-dichloro-ethane at -10 - 5℃; for 1h;100%
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene With aluminum (III) chloride In 1,2-dichloro-ethane at -10 - 2℃;
Stage #2: acetyl chloride In 1,2-dichloro-ethane at 0 - 5℃; for 1h;
100%
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene With aluminum (III) chloride In dichloromethane at -5 - 20℃;
Stage #2: acetyl chloride In dichloromethane at -5 - 0℃; for 6h;
89%
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene; acetyl chloride With aluminum (III) chloride In 1,2-dichloro-ethane at 0 - 10℃; for 1.16667h; Friedel-Crafts acylation; Inert atmosphere; Large scale reaction;
Stage #2: With water In ethyl acetate; 1,2-dichloro-ethane at 0 - 20℃; Large scale reaction;
88%
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

4-fluoro-2-methoxyphenylboronic acid
179899-07-1

4-fluoro-2-methoxyphenylboronic acid

2,2'-dimethoxy-4,4'-difluorobiphenyl
5400-65-7

2,2'-dimethoxy-4,4'-difluorobiphenyl

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water for 43h; Inert atmosphere; Reflux;99%
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

chloroacetone
78-95-5

chloroacetone

1-[(5-fluoro-2-methoxyphenyl) thio]-2-propanone
476198-75-1

1-[(5-fluoro-2-methoxyphenyl) thio]-2-propanone

Conditions
ConditionsYield
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene With tert.-butyl lithium; sulfur In tetrahydrofuran; pentane at -78℃; for 0.25h;
Stage #2: chloroacetone In tetrahydrofuran; pentane at -78℃; for 1h;
98%
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

C13H17BBrFO3

C13H17BBrFO3

Conditions
ConditionsYield
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Glovebox;95%
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Glovebox;
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

C13H17BBrFO3

C13H17BBrFO3

Conditions
ConditionsYield
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Glovebox;95%
7-hydroxy-5,8-dimethyl-2-naphthonitrile

7-hydroxy-5,8-dimethyl-2-naphthonitrile

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

7-(4-fluoro-2-methoxyphenoxy)-5,8-dimethyl-2-naphthonitrile

7-(4-fluoro-2-methoxyphenoxy)-5,8-dimethyl-2-naphthonitrile

Conditions
ConditionsYield
With copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate In 1,4-dioxane Inert atmosphere; Sealed tube; Heating;91%
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester
1121600-04-1

4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 110℃; for 16h; Temperature; Inert atmosphere;90%
With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene Inert atmosphere; Reflux;58%
With palladium diacetate; sodium t-butanolate; XPhos In toluene at 90℃; Buchwald-Hartwig Coupling;
[1,2-13C2]-acetyl chloride
89186-79-8

[1,2-13C2]-acetyl chloride

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

[13C2]1-(5-bromo-2-fluoro-4-methoxyphenyl)ethanone

[13C2]1-(5-bromo-2-fluoro-4-methoxyphenyl)ethanone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane90%
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

copper(I) cyanide
544-92-3

copper(I) cyanide

2-methoxy-4-fluorobenzonitrile
191014-55-8

2-methoxy-4-fluorobenzonitrile

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 180℃; for 5.5h;85%
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene; copper(I) cyanide In 1-methyl-pyrrolidin-2-one at 180℃; for 5h;
Stage #2: With ammonia In 1-methyl-pyrrolidin-2-one; water for 0.75h;
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene; copper(I) cyanide In 1-methyl-pyrrolidin-2-one at 180℃; for 5.5h;
Stage #2: With ammonium hydroxide In 1-methyl-pyrrolidin-2-one; water at 20℃; for 0.75h;
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene; copper(I) cyanide In 1-methyl-pyrrolidin-2-one at 180℃; for 5.5h;
Stage #2: With ammonia In 1-methyl-pyrrolidin-2-one; water at 20℃; for 0.75h;
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene; copper(I) cyanide In 1-methyl-pyrrolidin-2-one at 180℃; for 5.5h;
Stage #2: With ammonia In 1-methyl-pyrrolidin-2-one; water at 20℃; for 0.75h;
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

3-chloroprop-1-ene
107-05-1

3-chloroprop-1-ene

(2S,3S)-2-(4-fluoro-2-methoxyphenyl)-3-methyloxirane

(2S,3S)-2-(4-fluoro-2-methoxyphenyl)-3-methyloxirane

Conditions
ConditionsYield
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene With magnesium; lithium chloride In tetrahydrofuran at 70℃; for 1h;
Stage #2: 3-chloroprop-1-ene With iron(III)-acetylacetonate In tetrahydrofuran at 0 - 70℃;
Stage #3: With Oxone; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate In water; acetonitrile at 0℃; for 1.5h;
85%
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

C7H3(2)H3BrFO

C7H3(2)H3BrFO

Conditions
ConditionsYield
With water-d2; potassium carbonate; silver carbonate; cyclohexyldiphenylphosphine In toluene at 120℃; for 12h;85%
4-(benzoyloxy)morpholine
5765-65-1

4-(benzoyloxy)morpholine

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

C11H14FNO2

C11H14FNO2

Conditions
ConditionsYield
With norbornene; 1,4-bis(dicyclopentylphosphino)butane di-trifluoroborate; palladium diacetate; caesium carbonate; 1,7,7-trimethyl-endo-bicyclo[2.2.1]heptan-2-ol In 1,4-dioxane at 90℃; for 14h; Inert atmosphere; Sealed tube; chemoselective reaction;83%
Trimethyl borate
121-43-7

Trimethyl borate

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

4-fluoro-2-methoxyphenylboronic acid
179899-07-1

4-fluoro-2-methoxyphenylboronic acid

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran82%
5-fluoro-7-hydroxy-8-methyl-2-naphthonitrile

5-fluoro-7-hydroxy-8-methyl-2-naphthonitrile

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

5-fluoro-7-(4-fluoro-2-methoxyphenoxy)-8-methyl-2-naphthonitrile

5-fluoro-7-(4-fluoro-2-methoxyphenoxy)-8-methyl-2-naphthonitrile

Conditions
ConditionsYield
With copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate In 1,4-dioxane Inert atmosphere; Sealed tube; Heating;79%
5-chloro-7-hydroxy-8-methyl-2-naphthonitrile

5-chloro-7-hydroxy-8-methyl-2-naphthonitrile

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

5-chloro-7-(4-fluoro-2-methoxyphenoxy)-8-methyl-2-naphthonitrile

5-chloro-7-(4-fluoro-2-methoxyphenoxy)-8-methyl-2-naphthonitrile

Conditions
ConditionsYield
With copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate In 1,4-dioxane Inert atmosphere; Sealed tube; Heating;78%
bis(tri-t-butylphosphine)palladium(0)
53199-31-8

bis(tri-t-butylphosphine)palladium(0)

dichloromethane
75-09-2

dichloromethane

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

1,3-bis(cyclohexylphosphanyl)propane
97472-13-4

1,3-bis(cyclohexylphosphanyl)propane

C34H56BrFOP2Pd*0.62CH2Cl2

C34H56BrFOP2Pd*0.62CH2Cl2

Conditions
ConditionsYield
Stage #1: bis(tri-t-butylphosphine)palladium(0); 1,3-bis(cyclohexylphosphanyl)propane In toluene at 20℃; for 1h; Inert atmosphere;
Stage #2: 1-bromo-4-fluoro-2-methoxybenzene In toluene at 80℃; for 15h; Inert atmosphere;
Stage #3: dichloromethane
76%
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

C15H15BrO3
949019-87-8

C15H15BrO3

Conditions
ConditionsYield
Stage #1: 4-Methoxybenzyl alcohol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; Inert atmosphere;
Stage #2: 1-bromo-4-fluoro-2-methoxybenzene In N,N-dimethyl-formamide; mineral oil at 100℃; Inert atmosphere;
75%
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

(S)-2,2'-diamino-1,1'-binaphthalene
18531-95-8

(S)-2,2'-diamino-1,1'-binaphthalene

C27H21FN2O

C27H21FN2O

Conditions
ConditionsYield
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene; (S)-2,2'-diamino-1,1'-binaphthalene With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: With sodium tert-butoxide In toluene at 20 - 70℃; for 5.16667h; Schlenk technique; Inert atmosphere;
74.2%
8-fluoro-7-hydroxy-5-methyl-2-naphthonitrile

8-fluoro-7-hydroxy-5-methyl-2-naphthonitrile

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

8-fluoro-7-(4-fluoro-2-methoxyphenoxy)-5-methyl-2-naphthonitrile

8-fluoro-7-(4-fluoro-2-methoxyphenoxy)-5-methyl-2-naphthonitrile

Conditions
ConditionsYield
With copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate In 1,4-dioxane Inert atmosphere; Sealed tube; Heating;74%
cyclobutanone
1191-95-3

cyclobutanone

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

C11H13FO2

C11H13FO2

Conditions
ConditionsYield
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere;
Stage #2: cyclobutanone In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
71%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

4-(2-cyanopropan-2-yl)-2-methoxybenzonitrile

4-(2-cyanopropan-2-yl)-2-methoxybenzonitrile

Conditions
ConditionsYield
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran; hexane at -78 - 20℃; for 1h;
70%
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

C17H24BrNO4
1173006-38-6

C17H24BrNO4

Conditions
ConditionsYield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; Inert atmosphere;
Stage #2: 1-bromo-4-fluoro-2-methoxybenzene In N,N-dimethyl-formamide; mineral oil at 100℃; Inert atmosphere;
69%
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

4-fluoro-2-methoxybenzenethiol
398456-80-9

4-fluoro-2-methoxybenzenethiol

Conditions
ConditionsYield
With tert.-butyl lithium; sulfur In tetrahydrofuran; pentane at -78℃; for 1h;68%
With tert.-butyl lithium; sulfur In tetrahydrofuran; pentane at -78℃; for 1h;68%
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

3-bromo-6-fluoro-2-methoxybenzaldehyde
473416-74-9

3-bromo-6-fluoro-2-methoxybenzaldehyde

Conditions
ConditionsYield
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -78℃; for 0.833333h;
66%
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78℃; for 1h;
64%
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1.25h; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78℃; for 0.833333h; Inert atmosphere;
9.7 g
Stage #1: 1-bromo-4-fluoro-2-methoxybenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1.3h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexanes at -78℃; for 0.8h;
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

isopropyl alcohol
67-63-0

isopropyl alcohol

1-bromo-4-isopropoxy-2-methoxybenzene
176391-61-0

1-bromo-4-isopropoxy-2-methoxybenzene

Conditions
ConditionsYield
Stage #1: isopropyl alcohol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; Inert atmosphere;
Stage #2: 1-bromo-4-fluoro-2-methoxybenzene In N,N-dimethyl-formamide; mineral oil at 100℃; Inert atmosphere;
66%

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