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Shanghai Pinewood Fine Chemical Co., Ltd.

Appearance:OFF WHITE TO BROWN CRYSTALLINE POWDER Application:Doxepin Port:Shanghai

Dibenz[b,e]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:1 Metric Ton

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Dibenz[b,e]oxepin-11(6H)-one Manufacturer/High quality/Best price/In stock

Cas:4504-87-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Dibenz[B,E]Oxepin-11(6H)-One supplier in China

Cas:4504-87-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Dibenz[b,e]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 4504-87-4 Dibenz[b,e]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Dibenz[b,e]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Win-Win chemical Co.Ltd

Stock products, own laboratory Product number 35640 English Name 6H-benzo[c][1]benzoxepin-11-one CAS Number 4504-87-4 Purity 98%

Dibenz[b,e]oxepin-11(6H)-one CAS no.4504-87-4 98%

Cas:4504-87-4

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Product Name: Dibenz[b,e]oxepin-11(6H)-one Synonyms: 6,11-Dihydrobenz[b,e]oxepin-11-one;6,11-Dihydrodibenz[b,e]oxepin-11-one;DIBENZO[B,E]OXEPIN-11(6H)-ONE;DIBENZ[B,E]OXEPIN-11(6H)-ONE;DOXEPINONE;11-OXO-6,11

Dibenz[b,e]oxepin-11(6H)-one_

Cas:4504-87-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Factory Supply Dibenz[b,e]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New arrivalCAS 4504-87-4 with fast shipping

Cas:4504-87-4

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Dibenz[b,e]oxepin-11(6H)-one 4504-87-4

Cas:4504-87-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Dibenz[b,e]oxepin-11(6H)-one CAS: 4504-87-4 MF: C14H10O2 MW: 210.23 EINECS: 224-820-5 Mol File: 4504-87-4.mol Dibenz[b,e]oxepin-11(6H)-one Structure Dibenz[b,e]oxepin-11(6H)-one Chemical Properties Melting point

Dibenz[b,e]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Dibenz[b,e]oxepin-11(6H)-one CAS:4504-87-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organ

Dibenz[b,e]oxepin-11(6H)-one CAS:4504-87-4

Cas:4504-87-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Dibenz[b,e]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:4504-87-4

Cas:4504-87-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Dibenz[B,E]Oxepin-11(6H)-One

Cas:4504-87-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Think Chemical Co. Ltd

6,11-Dihydrodibenzo[b,e]oxepin-11-one CAS:4504-87-4 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing &amp

6,11-Dihydrodibenzo[b,e]oxepin-11-one

Cas:4504-87-4

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Dibenz[b,e]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Dibenz[B,E]Oxepin-11(6H)-One

Cas:4504-87-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:light yellow crystals powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:For medicine , pest

Dibenz[b,e]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

Dibenz[b,e]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Dibenz[b,e]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 6,11-dihydrodibenzo[b,e]oxepin-11-one CAS No,: 4504-87-4 Molecule Formula:C14H10O2 Molecule Weight:210.23 Purity: 99.0% Package: 25kg/drum Description:Light brown crystals powder Manufacture Standards:Enterprise Standard

Best Quality 6,11-dihydrodibenzo[b,e]oxepin-11-one

Cas:4504-87-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Doxepinone

Cas:4504-87-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

6,11-Dihydrodibenzo[b,e]oxepin-11-one

Cas:4504-87-4

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

6,11-Dihydrodibenz[b.e]oxepin-11-one

Cas:4504-87-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Doxepin Related Compound A (50 mg) (dibenzo[b,e]oxepin-11(6H)-one)

Cas:4504-87-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Dibenz[B,E]Oxepin-11(6H)-One

Cas:4504-87-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Dibenzo[b,E]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

Dibenz[b,e]oxepin-11(6H)-one

Cas:4504-87-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

2-(phenoxymethyl)benzoic acid
724-98-1

2-(phenoxymethyl)benzoic acid

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
With trifluoromethylsulfonic anhydride; boron trifluoride diethyl etherate In dichloromethane at 40℃; for 2h;98%
With boron trifluoride diethyl etherate; trifluoroacetic anhydride In dichloromethane at 20℃; for 1h;80.7%
With boron trifluoride diethyl etherate; trifluoroacetic anhydride In dichloromethane for 1h; Ambient temperature;79%
2-((2-bromobenzyl)oxy)benzonitrile

2-((2-bromobenzyl)oxy)benzonitrile

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Stage #1: 2-[(2-bromobenzyl)oxy]benzonitrile With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
74%
C14H10BrNO

C14H10BrNO

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Stage #1: C14H10BrNO With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
73%
doxepin hydrochloride
1229-29-4

doxepin hydrochloride

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
With dihydrogen peroxide for 1h; Heating;
2-benzofuran-1(3H)-one
87-41-2

2-benzofuran-1(3H)-one

<4-oxy-phthalic acid >-anhydride

<4-oxy-phthalic acid >-anhydride

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaH / dimethylformamide
1.2: 70.8 percent / dimethylformamide; benzene / 24 h / Heating
2.1: 80.7 percent / trifluoroacetic anhydride; boron trifluoride etherate / CH2Cl2 / 1 h / 20 °C
View Scheme
phenol
108-95-2

phenol

2-chlorobenzylhalide

2-chlorobenzylhalide

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaH / dimethylformamide
1.2: 70.8 percent / dimethylformamide; benzene / 24 h / Heating
2.1: 80.7 percent / trifluoroacetic anhydride; boron trifluoride etherate / CH2Cl2 / 1 h / 20 °C
View Scheme
sodium phenoxide
139-02-6

sodium phenoxide

monochloroacetate sodium

monochloroacetate sodium

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: P2O5 / ethanol
View Scheme
2-ethoxycarbonylbenzyl bromide
7115-91-5

2-ethoxycarbonylbenzyl bromide

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: P2O5 / ethanol
View Scheme
Multi-step reaction with 4 steps
1: sodium ethanolate / ethanol / 6.5 h / Reflux
2: sodium hydroxide; water / ethanol / 1 h / Reflux
3: thionyl chloride / 1 h / Reflux
4: aluminum (III) chloride / dichloromethane / 0.25 h / 0 °C
View Scheme
2-benzofuran-1(3H)-one
87-41-2

2-benzofuran-1(3H)-one

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1 h / 200 °C
2: 79 percent / (CF3CO)2O, BF3*Et2O / CH2Cl2 / 1 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: sodium methylate / ethanol / 4 h / 55 °C
2: aluminum (III) chloride / dimethyl sulfoxide / 8 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl-formamide; benzene / 24 h / Inert atmosphere; Schlenk technique; Reflux
2: Dichloromethyl methyl ether; iron(II) chloride / dichloromethane / 20 °C / Inert atmosphere; Schlenk technique
View Scheme
sodium phenoxide
139-02-6

sodium phenoxide

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1 h / 200 °C
2: 79 percent / (CF3CO)2O, BF3*Et2O / CH2Cl2 / 1 h / Ambient temperature
View Scheme
2-hydroxybromobenzene
95-56-7

2-hydroxybromobenzene

2-(bromomethyl)benzonitrile
22115-41-9

2-(bromomethyl)benzonitrile

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide
2: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
View Scheme
methyl 2-bromomethylbenzoate
2417-73-4

methyl 2-bromomethylbenzoate

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium methylate / ethanol / 4 h / 55 °C
2: sodium hydroxide / water / 6 h / 35 °C
3: aluminum (III) chloride / dimethyl sulfoxide / 8 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium methylate / ethanol / 4 h / 55 °C
2: sodium hydroxide / water / 6 h / 35 °C
3: trifluoroacetic anhydride / 1,2-dichloro-ethane / 8 h / 100 °C
View Scheme
methyl 2-(phenoxymethyl)benzoate
866996-44-3

methyl 2-(phenoxymethyl)benzoate

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 6 h / 35 °C
2: aluminum (III) chloride / dimethyl sulfoxide / 8 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 6 h / 35 °C
2: trifluoroacetic anhydride / 1,2-dichloro-ethane / 8 h / 100 °C
View Scheme
2-Methyl-benzoic acid methyl ester
89-71-4

2-Methyl-benzoic acid methyl ester

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-Bromosuccinimide / Petroleum ether / 2.5 h / 15 °C
2: sodium methylate / ethanol / 4 h / 55 °C
3: sodium hydroxide / water / 6 h / 35 °C
4: aluminum (III) chloride / dimethyl sulfoxide / 8 h / 100 °C
View Scheme
o-(chloromethyl)benzoic acid methyl ester
34040-62-5

o-(chloromethyl)benzoic acid methyl ester

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium methylate / ethanol / 4.5 h / 55 °C
2: sodium hydroxide / water / 6 h / 35 °C
3: trifluoroacetic anhydride / 1,2-dichloro-ethane / 8 h / 100 °C
View Scheme
phenol
108-95-2

phenol

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium methylate / ethanol / 4 h / 55 °C
2: sodium hydroxide / water / 6 h / 35 °C
3: trifluoroacetic anhydride / 1,2-dichloro-ethane / 8 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium methylate / ethanol / 4.5 h / 55 °C
2: sodium hydroxide / water / 6 h / 35 °C
3: trifluoroacetic anhydride / 1,2-dichloro-ethane / 8 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl-formamide; benzene / 24 h / Inert atmosphere; Schlenk technique; Reflux
2: Dichloromethyl methyl ether; iron(II) chloride / dichloromethane / 20 °C / Inert atmosphere; Schlenk technique
View Scheme
o-phthalic dicarboxaldehyde
643-79-8

o-phthalic dicarboxaldehyde

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: water / 0.75 h / 7 °C
2: sulfuric acid / 3 h / 70 °C
3: sodium methylate / ethanol / 4 h / 55 °C
4: aluminum (III) chloride / dimethyl sulfoxide / 8 h / 100 °C
View Scheme
2-(hydroxymethyl)benzoic acid
612-20-4

2-(hydroxymethyl)benzoic acid

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid / 3 h / 70 °C
2: sodium methylate / ethanol / 4 h / 55 °C
3: aluminum (III) chloride / dimethyl sulfoxide / 8 h / 100 °C
View Scheme
2-phenoxymethylbenzoyl chloride
21733-94-8

2-phenoxymethylbenzoyl chloride

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 0℃; for 0.25h; Friedel-Crafts Acylation;
ortho-methylbenzoic acid
118-90-1

ortho-methylbenzoic acid

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3.5 h / Reflux
3: sodium ethanolate / ethanol / 6.5 h / Reflux
4: sodium hydroxide; water / ethanol / 1 h / Reflux
5: thionyl chloride / 1 h / Reflux
6: aluminum (III) chloride / dichloromethane / 0.25 h / 0 °C
View Scheme
ethyl 2-methylbenzoate
87-24-1

ethyl 2-methylbenzoate

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3.5 h / Reflux
2: sodium ethanolate / ethanol / 6.5 h / Reflux
3: sodium hydroxide; water / ethanol / 1 h / Reflux
4: thionyl chloride / 1 h / Reflux
5: aluminum (III) chloride / dichloromethane / 0.25 h / 0 °C
View Scheme
2-Phenoxymethyl-benzoic acid ethyl ester
4504-85-2

2-Phenoxymethyl-benzoic acid ethyl ester

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; water / ethanol / 1 h / Reflux
2: thionyl chloride / 1 h / Reflux
3: aluminum (III) chloride / dichloromethane / 0.25 h / 0 °C
View Scheme
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

p-trifluoromethylphenyl bromide
402-43-7

p-trifluoromethylphenyl bromide

11-[4-(trifluoromethyl)phenyl]-6,11-dihydrodibenzo[b,e]oxepin-11-ol

11-[4-(trifluoromethyl)phenyl]-6,11-dihydrodibenzo[b,e]oxepin-11-ol

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 28h; Inert atmosphere;99%
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

11-hydroxy-6,11-dihydrodibenzo[b,e]oxepine
5251-26-3

11-hydroxy-6,11-dihydrodibenzo[b,e]oxepine

Conditions
ConditionsYield
With sodium tetrahydroborate86%
With sodium tetrahydroborate In methanol at 0℃; for 0.333333h;
With sodium tetrahydroborate In methanol at 20℃; for 2h;
bromobenzene
108-86-1

bromobenzene

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

11-phenyl-6,11-dihydro-5H-dibenzo[a,d]oxepin-11-ol

11-phenyl-6,11-dihydro-5H-dibenzo[a,d]oxepin-11-ol

Conditions
ConditionsYield
Stage #1: bromobenzene With magnesium In tetrahydrofuran for 0.333333h;
Stage #2: 6,11-dihydrodibenz[b,e]oxepin-11-one In tetrahydrofuran for 0.5h; Heating;
85%
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

3-(1,1-dimethylethoxy)-1-chloropropane
1190-17-6

3-(1,1-dimethylethoxy)-1-chloropropane

11-(3-tertbutoxypropyl)-11-hydroxy-6,11-dihydrodibenzo-[b,e]-oxepine
1612-63-1

11-(3-tertbutoxypropyl)-11-hydroxy-6,11-dihydrodibenzo-[b,e]-oxepine

Conditions
ConditionsYield
With magnesium In diethyl ether for 1h; Heating / reflux;80%
Stage #1: 3-(1,1-dimethylethoxy)-1-chloropropane With magnesium In diethyl ether
Stage #2: 6,11-dihydrodibenz[b,e]oxepin-11-one In diethyl ether for 1h; Heating / reflux;
Stage #3: With water; ammonium chloride In diethyl ether
80%
Stage #1: 3-(1,1-dimethylethoxy)-1-chloropropane With magnesium In diethyl ether
Stage #2: 6,11-dihydrodibenz[b,e]oxepin-11-one In diethyl ether for 1h; Heating / reflux;
Stage #3: With ammonium chloride In diethyl ether
80%
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

5-phenyl-2H-1,2,3,4-tetrazole
18039-42-4

5-phenyl-2H-1,2,3,4-tetrazole

6-(5-phenyl-2H-tetrazol-2-yl)dibenzo[b,e]oxepin-11(6H)-one

6-(5-phenyl-2H-tetrazol-2-yl)dibenzo[b,e]oxepin-11(6H)-one

Conditions
ConditionsYield
With tert.-butylhydroperoxide; water; tetra-(n-butyl)ammonium iodide at 90℃; for 9h; regioselective reaction;64%
4-chloro-1-methylpiperidine
5570-77-4

4-chloro-1-methylpiperidine

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

11-(1-methyl-piperidin-4-yl)-6,11-dihydro-dibenzo[b,e]oxepin-11-ol
51582-48-0

11-(1-methyl-piperidin-4-yl)-6,11-dihydro-dibenzo[b,e]oxepin-11-ol

Conditions
ConditionsYield
(i) EtMgBr, THF, (heating), (ii) /BRN= 1344817/, (heating); Multistep reaction;
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

methylenedimethyl sulfurane
6814-64-8, 40651-06-7

methylenedimethyl sulfurane

C15H12O2
105666-56-6

C15H12O2

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; dimethyl sulfoxide for 10h; Ambient temperature;
3-(N,N-dimethylamino)propylmagnesium chloride
19070-16-7

3-(N,N-dimethylamino)propylmagnesium chloride

6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

doxepin hydrochloride
1229-29-4

doxepin hydrochloride

Conditions
ConditionsYield
With hydrogenchloride 1.) THF, toluene, 65 deg C, 2 h, 2.) 1 h, 3.) 75 deg C, 1.5 h, ethanol; Multistep reaction;
Stage #1: 3-(N,N-dimethylamino)propylmagnesium chloride; 6,11-dihydrodibenz[b,e]oxepin-11-one In tetrahydrofuran; toluene at 65℃; for 2h;
Stage #2: With hydrogenchloride at 65℃; for 1.5h;
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

3-(Dimethylamino)propyl chloride
109-54-6

3-(Dimethylamino)propyl chloride

doxepin hydrochloride
1229-29-4

doxepin hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; 1,1-Dibromoethane; magnesium 1) THF, reflux; 2) THF, reflux;; Yield given. Multistep reaction;
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

(E)-Desmethyldoxepin
67035-76-1

(E)-Desmethyldoxepin

Conditions
ConditionsYield
Stage #1: [3-(methylamino)propyl](triphenyl)phosphonium bromide hydrobromide With n-butyllithium In tetrahydrofuran; n-heptane for 1.5h;
Stage #2: 6,11-dihydrodibenz[b,e]oxepin-11-one In tetrahydrofuran; n-heptane for 10h; Heating / reflux;
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

6,11-dihydrodibenz[b,e]oxepin

6,11-dihydrodibenz[b,e]oxepin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 86 percent / NaBH4
2: H2 / 10percent Pd-C / diethyl ether / 5 h / 1875.1 Torr / Ambient temperature
View Scheme
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

6,11-Dihydro-dibenzo[b,e]oxepine-11-carbaldehyde
154775-82-3

6,11-Dihydro-dibenzo[b,e]oxepine-11-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaH / dimethylsulfoxide; tetrahydrofuran / 10 h / Ambient temperature
2: BF3*Et2O / CH2Cl2 / 5 h
View Scheme
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

6,11-dihydrodibenzoxepin-11-carboxylic acid
144170-65-0

6,11-dihydrodibenzoxepin-11-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaH / dimethylsulfoxide; tetrahydrofuran / 10 h / Ambient temperature
2: BF3*Et2O / CH2Cl2 / 5 h
3: KMnO4 / acetone; 2-methyl-propan-2-ol / 1.5 h / pH 6.86
View Scheme
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

N-(2,6-diisopropylphenyl)-6,11-dihydrodibenzoxepin-11-carboxamide

N-(2,6-diisopropylphenyl)-6,11-dihydrodibenzoxepin-11-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaH / dimethylsulfoxide; tetrahydrofuran / 10 h / Ambient temperature
2: BF3*Et2O / CH2Cl2 / 5 h
3: KMnO4 / acetone; 2-methyl-propan-2-ol / 1.5 h / pH 6.86
4: 1.) oxalyl chloride, 2.) NEt3, 4-(N,N-dimethylamino)pyridine / 1.) CH2Cl2, 8 h, 2.) CH2Cl2, RT, 1.5 h
View Scheme
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

11-chloro-6,11-dihydrodibenzo[b,e]oxepine
19373-88-7

11-chloro-6,11-dihydrodibenzo[b,e]oxepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaBH4 / methanol / 0.33 h / 0 °C
2: SOCl2 / 0.17 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol / 2 h / 20 °C
2: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C
View Scheme
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

1-(6,11-Dihydrodibenzoxepin-11-yl)piperazine
129717-22-2

1-(6,11-Dihydrodibenzoxepin-11-yl)piperazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaBH4 / methanol / 0.33 h / 0 °C
2: SOCl2 / 0.17 h / Ambient temperature
3: CH2Cl2 / 2 h / Ambient temperature
View Scheme
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

1-(6,11-Dihydro-dibenzo[b,e]oxepin-11-yl)-4-((E)-3-phenyl-allyl)-piperazine; compound with (Z)-but-2-enedioic acid
114312-42-4, 139305-25-2

1-(6,11-Dihydro-dibenzo[b,e]oxepin-11-yl)-4-((E)-3-phenyl-allyl)-piperazine; compound with (Z)-but-2-enedioic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaBH4 / methanol / 0.33 h / 0 °C
2: SOCl2 / 0.17 h / Ambient temperature
3: 67 percent / CH2Cl2 / 1 h / Ambient temperature
View Scheme
6,11-dihydrodibenz[b,e]oxepin-11-one
4504-87-4

6,11-dihydrodibenz[b,e]oxepin-11-one

1-(6,11-Dihydro-dibenzo[b,e]oxepin-11-yl)-4-(3-phenyl-prop-2-ynyl)-piperazine; compound with (Z)-but-2-enedioic acid
139305-71-8

1-(6,11-Dihydro-dibenzo[b,e]oxepin-11-yl)-4-(3-phenyl-prop-2-ynyl)-piperazine; compound with (Z)-but-2-enedioic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaBH4 / methanol / 0.33 h / 0 °C
2: SOCl2 / 0.17 h / Ambient temperature
3: CH2Cl2 / 2 h / Ambient temperature
4: 18 percent / toluene / 8 h / Heating
View Scheme

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