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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

1,4-Dioxane-2,5-dione,3,6-dimethyl-,(3S,6S)- Manufacturer/High quality/Best price/In stock

Cas:4511-42-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality L-Lactide supplier in China

Cas:4511-42-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione

Cas:4511-42-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% L-Lactide S 4511-42-6 Producer

Cas:4511-42-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality L-Lactide

Cas:4511-42-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

CHemwill -- L-Lactide

Cas:4511-42-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

L-Lactide Basic information Product Name: L-Lactide Synonyms: PURASORB(R) L;(3S)-CIS-3,6-DIMETHYL-1,4-DIOXANE-2,5-DIONE;(3S,6S)-(-)-3,6-DIMETHYL-1,4-DIOXANE-2,5-DIONE;LACTIDE;LACTIDE(L-)

4511-42-6

Cas:4511-42-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

L-Lactide

Cas:4511-42-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 4511-42-6 with best quality

Cas:4511-42-6

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High quality L-Lactide CAS:4511-42-6 from good manufacture

Cas:4511-42-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

L-Lactide

Cas:4511-42-6

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Leader Biochemical Group

About Product Details

China Biggest factory Supply High Quality L-Lactide CAS 4511-42-6

Cas:4511-42-6

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:R.T Package:25kg/Barrel Application:Used to synthesize biodegradable copolymers Transportation:Express/Sea/Air Port:Any port in China

for sale L-Lactide cas:4511-42-6 Wholesaler

Cas:4511-42-6

Min.Order:1 Kilogram

FOB Price: $400.0 / 735.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,4-Dioxane-2,5-dione,3,6-dimethyl-,(3S,6S)- 4511-42-6

Cas:4511-42-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

L-Lactide

Cas:4511-42-6

Min.Order:1 Kilogram

FOB Price: $500.0 / 540.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

L-Lactide CAS:4511-42-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

L-Lactide CAS:4511-42-6

Cas:4511-42-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,4-Dioxane-2,5-dione,3,6-dimethyl-,(3S,6S)-

Cas:4511-42-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1,4-Dioxane-2,5-dione,3,6-dimethyl-,(3S,6S)-

Cas:4511-42-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

L-Lactide

Cas:4511-42-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

L-Lactide CAS4511-42-6

Cas:4511-42-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

L-Lactide CAS 4511-42-6 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 P

L-Lactide CAS 4511-42-6

Cas:4511-42-6

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hefei Zhaobo Technology Co., Ltd.

L-Lactide CAS 4511-42-6 Description Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality c

L-Lactide CAS 4511-42-6

Cas:4511-42-6

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

L-LACTIDE

Cas:4511-42-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

L-LACTIDE

Cas:4511-42-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

L-Lactide

Cas:4511-42-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality L-Lactide

Cas:4511-42-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

High quality L-Lactide CAS:4511-42-6 from good manufacture

Cas:4511-42-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

L-Lactide;(3S,6S)-3,6-Dimethyl-1,4-dioxane-2,5-dione.99%

Cas:4511-42-6

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

L-Lactide Chemical Properties Melting point 92-94 °C(lit.) Boiling point 255°C density 1.186±0.06 g/cm3(Predicted) refractive index 1.4475 storage temp. 2-8°C solubility Soluble in chloroform, and methanol.

L-(-)-Lactide

Cas:4511-42-6

Min.Order:1 Gram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

High quality L-Lactide CAS:4511-42-6 from good manufacture

Cas:4511-42-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Synthetic route

Reaxys ID: 11369849

Reaxys ID: 11369849

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
at 60 - 320℃; for 0.35 - 0.433333h; Product distribution / selectivity; Pyrolysis;100%
at 280℃; for 2h; Product distribution / selectivity; Pyrolysis;95.3%
Reaxys ID: 11385251

Reaxys ID: 11385251

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
tin octylate at 200℃; under 5 Torr; Product distribution / selectivity;99.3%
at 200℃; under 5 Torr; Product distribution / selectivity;99.3%
at 200℃; under 5 Torr; Product distribution / selectivity;
at 200℃; under 5 Torr; Product distribution / selectivity;
at 210℃; under 4 Torr; Product distribution / selectivity;
stannous lactate

stannous lactate

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
With benzylurea at 100 - 180℃; under 1 Torr; for 2h; Temperature; Reagent/catalyst; Pressure;96.72%
L-Lactic acid
79-33-4

L-Lactic acid

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
In water at 240℃; under 760.051 Torr; Inert atmosphere; Autoclave;94%
Stage #1: L-Lactic acid With 1-docosanol; 3-chloropyridinium trifluoromethanesulfonate at 140℃; under 25 Torr; for 12h;
Stage #2: at 160℃; under 1 Torr; for 3h; Reagent/catalyst; Pressure; Temperature; Time;
80%
Stage #1: L-Lactic acid With 1-docosanol; 3-chloropyridinium trifluoromethanesulfonate In water at 140℃; under 30.003 Torr; for 12h;
Stage #2: In water at 160℃; under 0.99985 Torr; for 3h; Reagent/catalyst;
79%
(S)-Ethyl lactate
687-47-8

(S)-Ethyl lactate

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
titanium(IV) tetraethanolate; Triethylene glycol dimethyl ether at 120℃; under 50 Torr; for 7.5h; Inert atmosphere;85.5%
Stage #1: (S)-Ethyl lactate With cerium(III) chloride heptahydrate In water Inert atmosphere;
Stage #2: for 4h; Reagent/catalyst;
52%
With Triethylene glycol dimethyl ether; titanium(IV) tetraethanolate at 120℃; for 6h; Product distribution / selectivity;
L-Lactic acid
79-33-4

L-Lactic acid

1-docosanol
661-19-8

1-docosanol

A

2-docosene
908335-80-8

2-docosene

B

methyl 2-docosyloxypropionate

methyl 2-docosyloxypropionate

C

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
Stage #1: L-Lactic acid; 1-docosanol With 3-chloropyridinium trifluoromethanesulfonate at 140℃; under 25 Torr; for 12h;
Stage #2: at 160℃; under 1 Torr; for 3h;
Stage #3: With methanol; potassium carbonate Reagent/catalyst; Pressure; Temperature; Time;
A n/a
B n/a
C 80%
L-Lactic acid
79-33-4

L-Lactic acid

(-)-menthol
2216-51-5

(-)-menthol

A

L-menthyl L-lactoyl L-lactate
923031-01-0

L-menthyl L-lactoyl L-lactate

B

L-menthyl L-lactoyl L-lactoyl L-lactate
923031-02-1

L-menthyl L-lactoyl L-lactoyl L-lactate

C

(1R,2S,5R)-menthyl (S)-(-)-lactate
61597-98-6

(1R,2S,5R)-menthyl (S)-(-)-lactate

D

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
In n-heptane; water at 128℃; for 32h; Product distribution / selectivity; Heating / reflux;A 24.6%
B 0.4%
C 67.7%
D 0.6%
sulfuric acid In n-heptane at 119℃; for 2h; Product distribution / selectivity;A 32.2%
B 1.9%
C 57.6%
D 0.4%
sodium hydrogen sulfate In n-heptane at 93 - 123℃; for 17h; Product distribution / selectivity; Heating / reflux;A 36.5%
B 5.6%
C 48.7%
D 4.8%
Reaxys ID: 11369848

Reaxys ID: 11369848

A

hexalactide

hexalactide

B

trilactide
859046-55-2

trilactide

C

C12H16O8

C12H16O8

D

C15H20O10
859046-57-4

C15H20O10

E

C21H28O14

C21H28O14

F

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

G

L,L-dilactide
4511-42-6

L,L-dilactide

H

D-lactide
13076-17-0

D-lactide

Conditions
ConditionsYield
at 60 - 400℃; for 0.566667h; Product distribution / selectivity; Pyrolysis;A 4.51%
B 3.26%
C 5.59%
D 6.02%
E 1.88%
F 18.28%
G n/a
H n/a
Reaxys ID: 11369849

Reaxys ID: 11369849

A

hexalactide

hexalactide

B

trilactide
859046-55-2

trilactide

C

C12H16O8

C12H16O8

D

C15H20O10
859046-57-4

C15H20O10

E

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

F

L,L-dilactide
4511-42-6

L,L-dilactide

G

D-lactide
13076-17-0

D-lactide

Conditions
ConditionsYield
at 60 - 400℃; for 0.566667h; Product distribution / selectivity; Pyrolysis;A 0.46%
B 0.5%
C 1.65%
D 0.75%
E 12.17%
F n/a
G n/a
methyl lactate
547-64-8

methyl lactate

A

methanol
67-56-1

methanol

B

DP2

DP2

C

DP3

DP3

D

DP4

DP4

E

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
Amberlys 36 resin at 104 - 115℃; under 25 - 80 Torr; for 28h; Heating / reflux;A n/a
B 7.4%
C 0.3%
D 0%
E 0%
Reaxys ID: 11369849

Reaxys ID: 11369849

A

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

B

L,L-dilactide
4511-42-6

L,L-dilactide

C

D-lactide
13076-17-0

D-lactide

Conditions
ConditionsYield
at 60 - 400℃; for 0.433333 - 0.566667h; Product distribution / selectivity; Pyrolysis;A 6.08%
B n/a
C n/a
Reaxys ID: 11369849

Reaxys ID: 11369849

A

C12H16O8

C12H16O8

B

C15H20O10
859046-57-4

C15H20O10

C

L,L-dilactide
4511-42-6

L,L-dilactide

D

D-lactide
13076-17-0

D-lactide

Conditions
ConditionsYield
at 60 - 300℃; for 0.4h; Product distribution / selectivity; Pyrolysis;A 0.28%
B 0.2%
C n/a
D n/a
(S,S)-2-[(2-hydroxypropanoyl)oxy]propanoic acid
923-17-1

(S,S)-2-[(2-hydroxypropanoyl)oxy]propanoic acid

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
Stage #1: (S,S)-2-[(2-hydroxypropanoyl)oxy]propanoic acid With 1,3,5-trichloro-2,4,6-triazine In acetone at 20℃;
Stage #2: With triethylamine In acetone for 1h; Further stages.;
sec-phenethyl O-lactoyllactate
620627-85-2

sec-phenethyl O-lactoyllactate

A

L,L-dilactide
4511-42-6

L,L-dilactide

B

[Y[2,2'-(1,4-dithiabutanediyl)-bis(4-methyl-6-tert-butylphenolato)]{N(SiHMe2)2}(THF)]

[Y[2,2'-(1,4-dithiabutanediyl)-bis(4-methyl-6-tert-butylphenolato)]{N(SiHMe2)2}(THF)]

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 100 percent / hydrogen / Pd/C / ethanol / 20 °C
2.1: cyanuric chloride / acetone / 20 °C
2.2: Et3N / acetone / 1 h
View Scheme
poly(L-lactic acid)

poly(L-lactic acid)

A

LACTIC ACID
849585-22-4

LACTIC ACID

B

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

C

L,L-dilactide
4511-42-6

L,L-dilactide

D

D-lactide
13076-17-0

D-lactide

Conditions
ConditionsYield
tin(II) octanoate at 210 - 230℃; under 22.5023 Torr; for 1 - 2h; Product distribution / selectivity;
zinc stearate at 210 - 230℃; under 22.5023 Torr; for 1 - 2h; Product distribution / selectivity;
tin(II) octanoate at 210 - 230℃; under 22.5023 Torr; for 1 - 2h; Product distribution / selectivity;
L-lactic acid oligomer

L-lactic acid oligomer

A

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

B

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
Stage #1: L-lactic acid oligomer at 140℃; for 730.5h;
Stage #2: tin(II) octanoate at 235℃; Product distribution / selectivity;
tin(II) octanoate at 120 - 230℃; Product distribution / selectivity;
L-lactic acid oligomer

L-lactic acid oligomer

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
tin(II) octanoate at 120 - 235℃; Product distribution / selectivity;
Reaxys ID: 11363805

Reaxys ID: 11363805

A

L,L-dilactide
4511-42-6

L,L-dilactide

B

D-lactide
13076-17-0

D-lactide

Conditions
ConditionsYield
tin octanoate at 60 - 300℃; for 0.4h; Product distribution / selectivity; Pyrolysis;
Reaxys ID: 11369849

Reaxys ID: 11369849

A

L,L-dilactide
4511-42-6

L,L-dilactide

B

D-lactide
13076-17-0

D-lactide

Conditions
ConditionsYield
at 60 - 320℃; for 0.433333h; Product distribution / selectivity; Pyrolysis;
(6S)-3-methylene-6-methyl-1,4-dioxane-2,5-dione
1071822-17-7

(6S)-3-methylene-6-methyl-1,4-dioxane-2,5-dione

A

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

B

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
With 10% Pd on charcoal; hydrogen In tetrahydrofuran at 20℃; under 21446.5 Torr; for 18h; Autoclave; optical yield given as %de;
(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

A

L,L-dilactide
4511-42-6

L,L-dilactide

B

D-lactide
13076-17-0

D-lactide

Conditions
ConditionsYield
Na-ethylhexanoate at 160℃; for 15h; Product distribution / selectivity; Racemisation; Parr reactor;
Multi-step reaction with 2 steps
1: potassium phosphate / ethyl acetate / 168 h / 20 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 4 h / 110 °C
View Scheme
L-Lactic acid
79-33-4

L-Lactic acid

A

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

B

L,L-dilactide
4511-42-6

L,L-dilactide

C

D-lactide
13076-17-0

D-lactide

Conditions
ConditionsYield
Stage #1: L-Lactic acid In water at 170℃; under 80 Torr; for 3h;
Stage #2: tin catalyst at 220℃; under 10 - 15 Torr; Product distribution / selectivity;
With potassium hydroxide; stannous octoate at 150 - 240℃; under 7.50075 Torr; Product distribution / selectivity;
Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
With Triethylene glycol dimethyl ether; titanium(IV) tetraethanolate at 120℃; for 7.5h; Inert atmosphere;
3,6-dimethyl-1,4-dioxane-2,5-dione

3,6-dimethyl-1,4-dioxane-2,5-dione

A

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

B

L,L-dilactide
4511-42-6

L,L-dilactide

C

D-lactide
13076-17-0

D-lactide

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 110℃; for 4h; optical yield given as %ee;
LACTIC ACID
849585-22-4

LACTIC ACID

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
Stage #1: LACTIC ACID at 70℃; under 60.006 Torr;
Stage #2: With tin(II) phosphite at 70 - 250℃; under 7.50075 - 15.0015 Torr; Pressure;
LACTIC ACID
849585-22-4

LACTIC ACID

A

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

B

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
Stage #1: LACTIC ACID at 70℃; under 60.006 Torr;
Stage #2: With tin(II) octanoate at 70 - 250℃; under 7.50075 - 15.0015 Torr;
L-Lactic acid
79-33-4

L-Lactic acid

(R)-2-hydroxylbutanoic acid
20016-85-7

(R)-2-hydroxylbutanoic acid

A

C7H10O4

C7H10O4

B

(R)-3,6-diethyl-1,4-dioxane-2,5-dione
1621671-24-6

(R)-3,6-diethyl-1,4-dioxane-2,5-dione

C

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
With H-BEA In o-xylene for 3h; Dean-Stark; Heating;A 46.5 %Chromat.
B 23.8 %Chromat.
C 29 %Chromat.
D-lactide
13076-17-0

D-lactide

A

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

B

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
With sodium sulfite at 190℃; for 4h; Reagent/catalyst; Temperature; stereoselective reaction;
(S)-Methyl lactate
27871-49-4

(S)-Methyl lactate

A

Methyl 2-(2-hydroxypropionyl)propionate
2037-15-2

Methyl 2-(2-hydroxypropionyl)propionate

B

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
13076-19-2

(3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione

C

L,L-dilactide
4511-42-6

L,L-dilactide

Conditions
ConditionsYield
With TiO2 on amorphous SiO2 at 220 - 300℃; under 760.051 Torr; Catalytic behavior; Reagent/catalyst; Inert atmosphere;
L,L-dilactide
4511-42-6

L,L-dilactide

poly-L-lactide

poly-L-lactide

Conditions
ConditionsYield
With [1,5-dithiapentadiyl-bis(4,6-di-t-Buphenol)Y{N(SiHMe2)2}THF] In toluene at 25℃; for 20h; Product distribution; Further Variations:; Reagents; Solvents;100%
With Ti[S(4-Me-6-tBu(C6H2O)2](NEt2)2 In toluene at 100℃; for 120h; Product distribution;90.3%
tin(II) octanoate at 100 - 180℃; for 1h;
L,L-dilactide
4511-42-6

L,L-dilactide

poly(L-lactide), Mn(GPC) = 6.00E-4, PDI = 2.01; monomer(s): L-lactide

poly(L-lactide), Mn(GPC) = 6.00E-4, PDI = 2.01; monomer(s): L-lactide

Conditions
ConditionsYield
With (TMS)2NYb[Me3SiNC(Ph)N(CH2)3NC(Ph)NSiMe3]2YbN(TMS)2 In toluene at 60℃; for 0.166667h;100%
L,L-dilactide
4511-42-6

L,L-dilactide

poly(L-lactide), Mn(GPC) = 4.10E-4, PDI = 1.31; monomer(s): L-lactide

poly(L-lactide), Mn(GPC) = 4.10E-4, PDI = 1.31; monomer(s): L-lactide

Conditions
ConditionsYield
With [Me3SiNC(Ph)N(CH2)3NC(Ph)NSiMe3]Yb[NH(2,6-iPr2C6H3)](DME) In toluene at 60℃; for 0.0166667h;100%
L,L-dilactide
4511-42-6

L,L-dilactide

Reaxys ID: 11841898

Reaxys ID: 11841898

Conditions
ConditionsYield
With N,N'-bis(2,6-diisopropylphenyl)-1,6,7,12-tetra-[4-(2-hydroxyethyl)phenoxy]perylene-3,4,9,10-tetracarboxylic acid diimide; stannous octoate In toluene at 90 - 110℃; for 48h;100%
C42H90ErO6P3 Product distribution / selectivity;
C28H62MgO4P2(2+)*2Cl(1-) Product distribution / selectivity;
methanol
67-56-1

methanol

L,L-dilactide
4511-42-6

L,L-dilactide

(S)-Methyl lactate
27871-49-4

(S)-Methyl lactate

Conditions
ConditionsYield
With [Mg(tbpca)2] In dichloromethane at 25℃; for 6h; Inert atmosphere; chemoselective reaction;99.5%
With Ca[N(SiMe3)2]2*2THF In toluene at 30℃; for 0.166667h;94%
With [Li6(methyl salicylato)6] at 25℃; for 2.5h; Time; Inert atmosphere; Glovebox;
triphenylmethyl sulfanylethyl alcohol
29167-28-0

triphenylmethyl sulfanylethyl alcohol

L,L-dilactide
4511-42-6

L,L-dilactide

polymer (H(O-CH(CH3)-CO)n-O-CH2CH2-S-(trityl)), Mn = 5500(SEC), 5000(NMR), Mw/Mn = 1.3; monomer(s): L-lactide; 2-(tritylsulfanyl)ethan-1-ol

polymer (H(O-CH(CH3)-CO)n-O-CH2CH2-S-(trityl)), Mn = 5500(SEC), 5000(NMR), Mw/Mn = 1.3; monomer(s): L-lactide; 2-(tritylsulfanyl)ethan-1-ol

Conditions
ConditionsYield
With stannous octoate In 1,4-dioxane at 60℃; for 40h;99%
triphenylmethyl sulfanylethyl alcohol
29167-28-0

triphenylmethyl sulfanylethyl alcohol

L,L-dilactide
4511-42-6

L,L-dilactide

polymer (H(O-CH(CH3)-CO)n-O-CH2CH2-S-(trityl)), Mn = 14600(SEC), 12400(NMR), Mw/Mn = 1.4; monomer(s): L-lactide; 2-(tritylsulfanyl)ethan-1-ol

polymer (H(O-CH(CH3)-CO)n-O-CH2CH2-S-(trityl)), Mn = 14600(SEC), 12400(NMR), Mw/Mn = 1.4; monomer(s): L-lactide; 2-(tritylsulfanyl)ethan-1-ol

Conditions
ConditionsYield
With stannous octoate In 1,4-dioxane at 60℃; for 40h;99%
triphenylmethyl sulfanylethyl alcohol
29167-28-0

triphenylmethyl sulfanylethyl alcohol

L,L-dilactide
4511-42-6

L,L-dilactide

polymer (-O-CH2CH2-S-(trityl) terminated), Mn = 3000(SEC), 2700(NMR), Mw/Mn = 1.4; monomer(s): L-lactide; 2-(tritylsulfanyl)ethan-1-ol

polymer (-O-CH2CH2-S-(trityl) terminated), Mn = 3000(SEC), 2700(NMR), Mw/Mn = 1.4; monomer(s): L-lactide; 2-(tritylsulfanyl)ethan-1-ol

Conditions
ConditionsYield
With stannous octoate In 1,4-dioxane99%
L,L-dilactide
4511-42-6

L,L-dilactide

benzyl alcohol
100-51-6

benzyl alcohol

poly-L-lactide with benzyl ester and hydroxyl end-groups, Mn = 14000, Mw/Mn = 1.37; monomer(s): L-lactide; benzyl alcohol

poly-L-lactide with benzyl ester and hydroxyl end-groups, Mn = 14000, Mw/Mn = 1.37; monomer(s): L-lactide; benzyl alcohol

Conditions
ConditionsYield
With 6-[MeOCH2CH2N(Me)CH2]-2,4-(tBu)2-phenolate lithium complex In dichloromethane at 26.5℃; for 0.25h;98%
ethanol
64-17-5

ethanol

L,L-dilactide
4511-42-6

L,L-dilactide

(S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester
64231-47-6

(S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester

Conditions
ConditionsYield
With [Mg(tbpca)2] In dichloromethane at 25℃; for 1h; Inert atmosphere; chemoselective reaction;98%
With [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid In toluene at 25 - 80℃; for 2h; Inert atmosphere;60%
With camphor-10-sulfonic acid In toluene at 25 - 80℃; for 2h;60%
With camphor-10-sulfonic acid In toluene at 25 - 80℃; for 2h;60%
Stage #1: ethanol With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: L,L-dilactide In tetrahydrofuran; hexane for 0.5h;
N-tert-butoxycarbonyl-3-aminopropanol
58885-58-8

N-tert-butoxycarbonyl-3-aminopropanol

L,L-dilactide
4511-42-6

L,L-dilactide

boc-aminopropyl-poly(lactic acid)20

boc-aminopropyl-poly(lactic acid)20

Conditions
ConditionsYield
Stage #1: L,L-dilactide In toluene at 80℃; for 1h;
Stage #2: N-tert-butoxycarbonyl-3-aminopropanol With diethylzinc In toluene at -10 - 20℃;
Stage #3: With acetic acid In toluene
98%
N-tert-butoxycarbonyl-3-aminopropanol
58885-58-8

N-tert-butoxycarbonyl-3-aminopropanol

L,L-dilactide
4511-42-6

L,L-dilactide

boc-aminopropyl-poly(lactic acid)30

boc-aminopropyl-poly(lactic acid)30

Conditions
ConditionsYield
Stage #1: N-tert-butoxycarbonyl-3-aminopropanol With diethylzinc In toluene at -10 - 20℃; for 1h;
Stage #2: L,L-dilactide In toluene at 80℃; for 2h;
Stage #3: With acetic acid In toluene Product distribution / selectivity;
98%
N-tert-butoxycarbonyl-3-aminopropanol
58885-58-8

N-tert-butoxycarbonyl-3-aminopropanol

L,L-dilactide
4511-42-6

L,L-dilactide

boc-aminopropyl-poly(lactic acid)50

boc-aminopropyl-poly(lactic acid)50

Conditions
ConditionsYield
Stage #1: N-tert-butoxycarbonyl-3-aminopropanol With diethylzinc In toluene at -10 - 20℃; for 1h;
Stage #2: L,L-dilactide In toluene at 80℃; for 2h;
Stage #3: With acetic acid In toluene
98%
N-tert-butoxycarbonyl-3-aminopropanol
58885-58-8

N-tert-butoxycarbonyl-3-aminopropanol

L,L-dilactide
4511-42-6

L,L-dilactide

boc-aminopropyl-poly(lactic acid)80

boc-aminopropyl-poly(lactic acid)80

Conditions
ConditionsYield
Stage #1: L,L-dilactide In toluene at 80℃; for 1h;
Stage #2: N-tert-butoxycarbonyl-3-aminopropanol With diethylzinc In toluene at -10 - 20℃;
Stage #3: With acetic acid In toluene
98%
C39H47N5O13*ClH

C39H47N5O13*ClH

L,L-dilactide
4511-42-6

L,L-dilactide

C129H167N5O73

C129H167N5O73

Conditions
ConditionsYield
Stage #1: C39H47N5O13*ClH With sodium hydroxide In water
Stage #2: L,L-dilactide With dmap In N,N-dimethyl-formamide at 55℃;
98%
triphenylmethyl sulfanylethyl alcohol
29167-28-0

triphenylmethyl sulfanylethyl alcohol

L,L-dilactide
4511-42-6

L,L-dilactide

polymer (H(O-CH(CH3)-CO)n-O-CH2CH2-S-(trityl)), Mn = 10100(SEC), 8200(NMR), Mw/Mn = 1.3; monomer(s): L-lactide; 2-(tritylsulfanyl)ethan-1-ol

polymer (H(O-CH(CH3)-CO)n-O-CH2CH2-S-(trityl)), Mn = 10100(SEC), 8200(NMR), Mw/Mn = 1.3; monomer(s): L-lactide; 2-(tritylsulfanyl)ethan-1-ol

Conditions
ConditionsYield
With stannous octoate In 1,4-dioxane at 60℃; for 40h;97%
methanol
67-56-1

methanol

L,L-dilactide
4511-42-6

L,L-dilactide

(1-methoxy-1-oxopropane-2-yl)-2-hydroxypropionate

(1-methoxy-1-oxopropane-2-yl)-2-hydroxypropionate

Conditions
ConditionsYield
With potassium hexamethylsilazane at 55℃; for 1h;97%
With [Zn(N-[methyl(2-hydroxy-3,5-di-tert-butylphenyl)]-N-methyl-N-cyclohexylamine(-1H))2] In dichloromethane at 20℃; Reagent/catalyst; Solvent; Temperature; Schlenk technique;
at 25℃; for 241h; Time; Inert atmosphere; Glovebox;
triphenylmethyl sulfanylethyl alcohol
29167-28-0

triphenylmethyl sulfanylethyl alcohol

L,L-dilactide
4511-42-6

L,L-dilactide

polymer (H(O-CH(CH3)CO)n-O-CH2CH2-S-(trityl)), Mn = 15300(SEC), 19000(NMR), Mw/Mn = 1.9; monomer(s): L-lactide; 2-(tritylsulfanyl)ethan-1-ol

polymer (H(O-CH(CH3)CO)n-O-CH2CH2-S-(trityl)), Mn = 15300(SEC), 19000(NMR), Mw/Mn = 1.9; monomer(s): L-lactide; 2-(tritylsulfanyl)ethan-1-ol

Conditions
ConditionsYield
With stannous octoate In 1,4-dioxane at 60℃; for 40h;96%
L,L-dilactide
4511-42-6

L,L-dilactide

benzyl alcohol
100-51-6

benzyl alcohol

α-H-ω-benzyl-terminated poly[(S)-oxy-1,1-ethanediyl-carbonyl-oxy-1,1-ethanediyl-carbonyl], ring opening polymerization product; monomer(s): L-lactide; benzyl alcohol

α-H-ω-benzyl-terminated poly[(S)-oxy-1,1-ethanediyl-carbonyl-oxy-1,1-ethanediyl-carbonyl], ring opening polymerization product; monomer(s): L-lactide; benzyl alcohol

Conditions
ConditionsYield
With tert-Butoxybis(dimethylamino)methane In tetrahydrofuran at 70℃; for 0.166667h; Product distribution; Further Variations:; Reagents; Pressures; vacuum;96%
L,L-dilactide
4511-42-6

L,L-dilactide

poly(lactide), by ring-opening polimerization, Mn (GPC) = 13700, Mw/Mn = 1.06; monomer(s): L-lactide

poly(lactide), by ring-opening polimerization, Mn (GPC) = 13700, Mw/Mn = 1.06; monomer(s): L-lactide

Conditions
ConditionsYield
With benzyl alcohol In toluene at 50℃; for 0.5h;96%
L,L-dilactide
4511-42-6

L,L-dilactide

poly(L-lactide), Mn(GPC) = 6.50E-4, PDI = 1.29; monomer(s): L-lactide

poly(L-lactide), Mn(GPC) = 6.50E-4, PDI = 1.29; monomer(s): L-lactide

Conditions
ConditionsYield
With [Me3SiNC(Ph)N(CH2)3NC(Ph)NSiMe3]Yb[NH(2,6-iPr2C6H3)](DME) In toluene at 60℃; for 0.116667h;95%
L,L-dilactide
4511-42-6

L,L-dilactide

benzyl alcohol
100-51-6

benzyl alcohol

poly(L-lactide), benzyl ester at one chain-end, Mn = 10300, Mw/Mn = 1.08

poly(L-lactide), benzyl ester at one chain-end, Mn = 10300, Mw/Mn = 1.08

Conditions
ConditionsYield
(MeOCH2CH2N-{CH2-[2-LiO-3,5-C6H2(tBu)2]}2)2 In dichloromethane at 26.5℃; for 0.25h;95%
L,L-dilactide
4511-42-6

L,L-dilactide

benzyl alcohol
100-51-6

benzyl alcohol

benzyl (S)-Lactate
56777-24-3

benzyl (S)-Lactate

Conditions
ConditionsYield
With Ca[N(SiMe3)2]2*2THF In toluene at 30℃; for 0.0833333h;95%
L,L-dilactide
4511-42-6

L,L-dilactide

butan-1-ol
71-36-3

butan-1-ol

C124H170O81

C124H170O81

Conditions
ConditionsYield
With Rasta resin-(1,5,7-triazabicyclo[4.4.0]dec-5-ene)[RR-TBD] In chloroform-d1 at 20℃; for 2h;95%
Sorbyl alcohol
17102-64-6

Sorbyl alcohol

L,L-dilactide
4511-42-6

L,L-dilactide

polylactic acid

polylactic acid

Conditions
ConditionsYield
Stage #1: Sorbyl alcohol With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: L,L-dilactide In tetrahydrofuran; hexane at -78 - 20℃;
Stage #3: With acetic acid In tetrahydrofuran; hexane
94.4%
ethanol
64-17-5

ethanol

L,L-dilactide
4511-42-6

L,L-dilactide

sorbinyl chloride
2614-88-2

sorbinyl chloride

polylactic acid

polylactic acid

Conditions
ConditionsYield
Stage #1: ethanol With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: L,L-dilactide In tetrahydrofuran; hexane at -78 - 20℃;
Stage #3: sorbinyl chloride In tetrahydrofuran; hexane at -78℃; for 1h;
94.2%

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