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Jiangsu Huaen Energy Co., Ltd.

Colorless or yellowish transparent liquid

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:0

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

4-(Trifluoromethoxy)aniline Manufacturer/High quality/Best price/In stock

Cas:461-82-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-(Trifluoromethoxy)Aniline

Cas:461-82-5

Min.Order:1 Kilogram

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Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 461-82-5 4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

Located in Zhengdong New District, Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is comprehensive high-tech modern enterprises integrating professional R&D, production and sales. Strong technical force, with a long-term professio

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:1 Kilogram

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Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-(trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% 4-Trifluoromethoxyaniline 461-82-5 Producer

Cas:461-82-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:1 Kilogram

FOB Price: $8.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

4-(Trifluoromethoxy)Aniline

Cas:461-82-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-(Trifluoromethoxy)-aniline

Cas:461-82-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

4-(trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 4-(Trifluoromethoxy)aniline CAS No. 461-82-5

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:1 Metric Ton

FOB Price: $12.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can

4-(Trifluoromethoxy)aniline CAS:461-82-5

Cas:461-82-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 461-82-5 with best quality

Cas:461-82-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

4-(Trifluoromethoxy)aniline CAS461-82-5

Cas:461-82-5

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-(Trifluoromethoxy)aniline 461-82-5

Cas:461-82-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

For the synthesis of fluorinated pharmaceutical, pesticide intermediates. Appearance:white powder Storage:Store below +30°C Package: according to customers' requirements Application:For the synthesis of fluorinated pharmaceutical, pesticide interm

The best quality intermediates,4-(Trifluoromethoxy)aniline,cas:461-82-5

Cas:461-82-5

Min.Order:1 Kilogram

FOB Price: $100.0 / 110.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

4-(Trifluoromethoxy)aniline CAS:461-82-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

4-(Trifluoromethoxy)aniline CAS:461-82-5

Cas:461-82-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

CAS 461-82-5 4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:1 Metric Ton

FOB Price: $11000.0 / 12000.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Hangzhou Yunuo Chemical Co., Ltd is located in Hangzhou city China. As a global supplier in the chemical industry, Yunuochem is to create added value for customers around the world. Sticking to such business idea of "Good faith wins the busin

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-(Trifluoromethoxy)Aniline

Cas:461-82-5

Min.Order:0

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Type:Manufacturers

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Triumph International Development Limilted

Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS461-82-5 4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-(Trifluoromethoxy)aniline

Cas:461-82-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
Stage #1: 1-trifluoromethoxybenzene With sodium ferrate(VI); sodium bromide In dimethyl sulfoxide at 95℃; for 4h; Inert atmosphere;
Stage #2: With sodium amide In dimethyl sulfoxide at 155℃; under 3040.2 Torr; for 10h; Solvent; Temperature; Reagent/catalyst; Pressure; Inert atmosphere;
98.2%
Multi-step reaction with 2 steps
1: sulfuric acid; nitric acid / dichloromethane / 2 h / 0 - 30 °C
2: iron; hydrogenchloride / methanol / 2 h / 60 - 65 °C
View Scheme
4-nitrophenyl trifluoromethyl ether
713-65-5

4-nitrophenyl trifluoromethyl ether

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
With C36H56Cl3CrN2O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In tetrahydrofuran at 60℃; for 24h; Inert atmosphere;92%
With hydrogen; ShPAK-0.5 In methanol at 44 - 46℃; under 29420.3 - 30891.3 Torr;89%
With hydrogenchloride; iron In methanol at 60 - 65℃; for 2h;
N-benzyl-4-(trifluoromethoxy)benzenamine

N-benzyl-4-(trifluoromethoxy)benzenamine

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
With formic acid; potassium hydroxide In ethanol at 70℃; for 1h;91%
1‐azido‐4‐(trifluoromethoxy)benzene
876012-82-7

1‐azido‐4‐(trifluoromethoxy)benzene

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
Stage #1: 1‐azido‐4‐(trifluoromethoxy)benzene With hydrazine hydrate for 0.166667h; Inert atmosphere;
Stage #2: for 7h; Irradiation; chemoselective reaction;
85%
trifluoromethan
75-46-7

trifluoromethan

4-amino-phenol
123-30-8

4-amino-phenol

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
With sodium methylate In methanol at 60℃; under 2250.23 Torr; for 4h; Autoclave; Inert atmosphere;83%
1-bromo-4-(trifluoromethoxy)benzene
407-14-7

1-bromo-4-(trifluoromethoxy)benzene

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
With dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 60℃; for 24h; Inert atmosphere;82%
Stage #1: 1-bromo-4-(trifluoromethoxy)benzene With magnesium In tetrahydrofuran Inert atmosphere;
Stage #2: With C10H17NO In tetrahydrofuran; toluene at -20℃; for 2h; Inert atmosphere;
Stage #3: With ammonium chloride In tetrahydrofuran; water; toluene Inert atmosphere;
62%
Stage #1: 1-bromo-4-(trifluoromethoxy)benzene With magnesium; ethylene dibromide In tetrahydrofuran Inert atmosphere;
Stage #2: With C10H17NO In tetrahydrofuran; toluene at -20℃; for 2h; Inert atmosphere;
62%
N-methyl-4-(trifluoromethoxy)aniline
41419-59-4

N-methyl-4-(trifluoromethoxy)aniline

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
With piperidine; dichloro(dimethylglyoxime)(dimethylglyoximato)cobalt(III); (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In acetonitrile at -78℃; for 24h; Reagent/catalyst; Sealed tube; Inert atmosphere; Irradiation;73%
N-2-propynyl-4-(trifluoromethoxy)benzenamine
82050-00-8

N-2-propynyl-4-(trifluoromethoxy)benzenamine

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
With palladium on activated charcoal; ethanolamine In water at 80℃; Inert atmosphere;61%
4-trifluoromethoxybenzamide
456-71-3

4-trifluoromethoxybenzamide

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
With potassium hydroxide; bromine
4-(Trichloromethoxy)benzoyl chloride
36823-89-9

4-(Trichloromethoxy)benzoyl chloride

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SbCl5; SbF3
2: aqueous NH3
3: bromine; aqueous KOH
View Scheme
4-(trifluoromethoxy)benzonitrile
332-25-2

4-(trifluoromethoxy)benzonitrile

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq.-ethanolic NaOH; aqueous H2O2
2: bromine; aqueous KOH
View Scheme
4-cyanophenyl trichloromethyl ether
100114-88-3

4-cyanophenyl trichloromethyl ether

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SbF3; SbCl5
2: aq.-ethanolic NaOH; aqueous H2O2
3: bromine; aqueous KOH
View Scheme
4-(trifluoromethoxy)benzoyl fluoride
330-11-0

4-(trifluoromethoxy)benzoyl fluoride

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous NH3
2: bromine; aqueous KOH
View Scheme
4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: PCl5; chlorine
2: SbCl5; SbF3
3: aqueous NH3
4: bromine; aqueous KOH
View Scheme
4-methoxybenzonitrile
874-90-8

4-methoxybenzonitrile

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: PCl5; chlorine
2: SbF3; SbCl5
3: aq.-ethanolic NaOH; aqueous H2O2
4: bromine; aqueous KOH
View Scheme
methoxybenzene
100-66-3

methoxybenzene

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: chlorine; 4-chlorobenzotrifluoride / 90 - 100 °C / UV-irradiation
2: hydrogen fluoride / 80 °C / 22502.3 - 26252.6 Torr / Inert atmosphere; Autoclave
3: sulfuric acid; nitric acid / dichloromethane / 2 h / 0 - 30 °C
4: iron; hydrogenchloride / methanol / 2 h / 60 - 65 °C
View Scheme
(trichloromethoxy)benzene
34888-05-6

(trichloromethoxy)benzene

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen fluoride / 80 °C / 22502.3 - 26252.6 Torr / Inert atmosphere; Autoclave
2: sulfuric acid; nitric acid / dichloromethane / 2 h / 0 - 30 °C
3: iron; hydrogenchloride / methanol / 2 h / 60 - 65 °C
View Scheme
1-phenyl-N-(4-(trifluoromethoxy)phenyl)methanimine

1-phenyl-N-(4-(trifluoromethoxy)phenyl)methanimine

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol / 5 °C
2: formic acid; potassium hydroxide; / ethanol / 1 h / 70 °C
View Scheme
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

4-(4-trifluoromethoxyaniline)piperidin-1-yl-formic acid tert-butyl ester
501673-86-5

4-(4-trifluoromethoxyaniline)piperidin-1-yl-formic acid tert-butyl ester

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 18h; Inert atmosphere;100%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

5-carboethoxypyridine-2-carboxylic acid
17880-34-1

5-carboethoxypyridine-2-carboxylic acid

ethyl 6-((4-(trifluoromethoxy)phenyl)carbamoyl)nicotinate
1437125-50-2

ethyl 6-((4-(trifluoromethoxy)phenyl)carbamoyl)nicotinate

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃;100%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-4-chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine
1583284-79-0

1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-4-chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-6-(methylthio)-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1583285-05-5

1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-6-(methylthio)-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
In ethanol for 12h; Reflux; Inert atmosphere;100%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

C16H15FN2O2

C16H15FN2O2

1-{6-[2-(tert-butyl)phenoxy]-2-fluoropyridin-3-yl}-3-[4-(trifluoromethoxy)phenyl]urea

1-{6-[2-(tert-butyl)phenoxy]-2-fluoropyridin-3-yl}-3-[4-(trifluoromethoxy)phenyl]urea

Conditions
ConditionsYield
In toluene at 80℃; for 24h; Inert atmosphere;100%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

5-fluoro-2H-benzo[d][1,3]-oxazine-2,4(1H)-dione
78755-94-9

5-fluoro-2H-benzo[d][1,3]-oxazine-2,4(1H)-dione

2-amino-6-fluoro-N-(4-(trifluoromethoxy)phenyl)benzamide

2-amino-6-fluoro-N-(4-(trifluoromethoxy)phenyl)benzamide

Conditions
ConditionsYield
In toluene for 4h; Reflux;100%
5-fluoroisatoic anhydride
321-69-7

5-fluoroisatoic anhydride

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

2-amino-5-fluoro-N-(4-(trifluoromethoxy)phenyl)benzamide

2-amino-5-fluoro-N-(4-(trifluoromethoxy)phenyl)benzamide

Conditions
ConditionsYield
In toluene for 4h; Reflux;100%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

5-bromo-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide

5-bromo-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 6h;100%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

N-(4-(trifluoromethoxy)phenyl)acetamide
1737-06-0

N-(4-(trifluoromethoxy)phenyl)acetamide

Conditions
ConditionsYield
With acetic anhydride In acetic acid99.9%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

2,6-dibromo-4-(trifluoromethoxy)aniline
88149-49-9

2,6-dibromo-4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide; sodium bromide at 30 - 55℃; for 3h; Reagent/catalyst;99.2%
With bromine chloride; triethylamine In chloroform at 35℃; for 12h; Solvent; Reagent/catalyst; Temperature;90%
With N-Bromosuccinimide In acetonitrile at 20℃; for 12h;89%
With bromine; acetic acid at 20℃; for 4.5h; Molecular sieve;
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

1-isocyanato-4-trifluoromethoxy-benzene
35037-73-1

1-isocyanato-4-trifluoromethoxy-benzene

Conditions
ConditionsYield
In tetrahydrofuran for 0.75h; Reflux;99%
In tetrahydrofuran for 0.75h; Reflux;99%
With pyrographite In ethyl acetate Heating;
Stage #1: 4-(trifluoromethoxy)aniline With hydrogenchloride In ethyl acetate
Stage #2: trichloromethyl chloroformate In toluene for 2.5h; Reflux; Inert atmosphere;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

tert-butyl N-(4-trifluoromethoxyphenyl)carbamate
212696-37-2

tert-butyl N-(4-trifluoromethoxyphenyl)carbamate

Conditions
ConditionsYield
In toluene at 100℃;99%
In toluene for 2h; Reflux;99%
With Amberlyst A21 In neat (no solvent) at 20℃; for 0.416667h; Green chemistry;92%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

4-trifluoromethoxy-N,N-bis(trimethylsilyl)aniline

4-trifluoromethoxy-N,N-bis(trimethylsilyl)aniline

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -75℃;99%
thiophosgene
463-71-8

thiophosgene

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

1-isothiocyanato-4-(trifluoromethoxy)benzene
64285-95-6

1-isothiocyanato-4-(trifluoromethoxy)benzene

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water at 23℃; for 1h;99%
With sodium hydroxide In chloroform; water at 0℃; for 24h;72%
With triethylamine In dichloromethane at 20℃; for 1h;
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

cis-1,2-diphenyloxirane
1689-71-0

cis-1,2-diphenyloxirane

(1S,2S)-1,2-diphenyl-2-(4-(trifluoromethoxy)phenylamino)ethanol
1113056-76-0

(1S,2S)-1,2-diphenyl-2-(4-(trifluoromethoxy)phenylamino)ethanol

Conditions
ConditionsYield
With indium(III) triflate; C28H48N4O4 In tetrahydrofuran at 0℃; for 69h; Molecular sieve; Inert atmosphere; optical yield given as %ee; enantioselective reaction;99%
1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

4,6-dichloro-N-(4-trifluoromethoxyphenyl)-1,3,5-triazin-2-amine
1138566-82-1

4,6-dichloro-N-(4-trifluoromethoxyphenyl)-1,3,5-triazin-2-amine

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 0 - 20℃; for 17h;99%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

4,4′-bis(trifluoromethoxy)azobenzene

4,4′-bis(trifluoromethoxy)azobenzene

Conditions
ConditionsYield
With pyridine; oxygen; copper; ammonium bromide In toluene at 100℃; under 760.051 Torr;99%
With copper-manganese spinel oxide In ethyl acetate at 80℃; for 3h;94%
With Ag/C; potassium hydroxide In dimethyl sulfoxide at 60℃; under 760.051 Torr; for 24h; Catalytic behavior; Green chemistry;67%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

2,3,6-trifluorobenzaldehyde
104451-70-9

2,3,6-trifluorobenzaldehyde

(E)-N-(4-(trifluoromethoxy)phenyl)-1-(2,3,6-trifluorophenyl)methanimine

(E)-N-(4-(trifluoromethoxy)phenyl)-1-(2,3,6-trifluorophenyl)methanimine

Conditions
ConditionsYield
In toluene at 110℃; for 96h; Dean-Stark;99%
2,6-difluorobenzaldehyde
437-81-0

2,6-difluorobenzaldehyde

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

(E)-1-(2,6-difluorophenyl)-N-(4-(trifluoromethoxy)phenyl)methanimine

(E)-1-(2,6-difluorophenyl)-N-(4-(trifluoromethoxy)phenyl)methanimine

Conditions
ConditionsYield
In toluene at 110℃; for 96h; Dean-Stark;99%
In toluene for 96h; Dean-Stark; Reflux;
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

N-(4-(trifluoromethoxy)phenyl)benzenesulfonamide

N-(4-(trifluoromethoxy)phenyl)benzenesulfonamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 18h; Schlenk technique; Inert atmosphere; Darkness;99%
3-bromo-3-methyl-2-indolinone
2406-05-5

3-bromo-3-methyl-2-indolinone

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

(R)-3-methyl-3-((4-(trifluoromethoxy)phenyl)amino)indolin-2-one

(R)-3-methyl-3-((4-(trifluoromethoxy)phenyl)amino)indolin-2-one

Conditions
ConditionsYield
Stage #1: 3-bromo-3-methyl-2-indolinone With nickel(II) tetrafluoroborate hexahydrate; C42H66N4O8 In ethyl acetate at 35℃; for 0.583333h;
Stage #2: With N-ethyl-N,N-diisopropylamine In ethyl acetate at 0℃; for 0.166667h;
Stage #3: 4-(trifluoromethoxy)aniline In ethyl acetate at 0℃; for 24h; enantioselective reaction;
99%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

t-butyl 2-diazopropanoate
805237-13-2

t-butyl 2-diazopropanoate

(-)-tert-butyl 2-((4-(trifluoromethoxy)phenyl)amino)propanoate

(-)-tert-butyl 2-((4-(trifluoromethoxy)phenyl)amino)propanoate

Conditions
ConditionsYield
With C32H30N4O4; copper(l) chloride In dichloromethane at 0℃; for 18h; Inert atmosphere; Molecular sieve; optical yield given as %ee; enantioselective reaction;98%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N-(4-(trifluoromethoxyl)phenyl)formamide

N-(4-(trifluoromethoxyl)phenyl)formamide

Conditions
ConditionsYield
With dipotassium peroxodisulfate In water at 100℃; for 0.166667h; Microwave irradiation; Green chemistry;98%
With sodium t-butanolate In neat (no solvent) at 20℃; for 3h; Inert atmosphere; Glovebox;97%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Ethoxymethylenemalononitrile
123-06-8

Ethoxymethylenemalononitrile

2-[(4-(trifluoromethoxy)phenylamino)methylidene]malononitrile

2-[(4-(trifluoromethoxy)phenylamino)methylidene]malononitrile

Conditions
ConditionsYield
In ethanol at 120℃; for 1h;98%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

chloroacetyl chloride
79-04-9

chloroacetyl chloride

2-chloro-N-(4-(trifluoromethoxy)phenyl)acetamide

2-chloro-N-(4-(trifluoromethoxy)phenyl)acetamide

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 2h;97.79%
With triethylamine In dichloromethane at 0℃; for 4h;
With triethylamine In acetone at 0 - 20℃;
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

methyl chloroformate
79-22-1

methyl chloroformate

methyl N-[(4-trifluoromethoxy)phenyl]carbamate

methyl N-[(4-trifluoromethoxy)phenyl]carbamate

Conditions
ConditionsYield
With dmap; triethylamine In 1,2-dichloro-ethane at 0 - 15℃; for 2h;97.4%
With sodium hydrogencarbonate In dichloromethane; water at 10 - 25℃; for 3h;95.7%
Stage #1: 4-(trifluoromethoxy)aniline With triethylamine In 1,2-dichloro-ethane at 0℃; for 0.166667h;
Stage #2: methyl chloroformate In 1,2-dichloro-ethane at 0 - 20℃;
92.8%
3-nitrophthalic acid anhydride
641-70-3

3-nitrophthalic acid anhydride

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

N-(4-trifluoromethoxyphenyl)-3-nitrophthalimide

N-(4-trifluoromethoxyphenyl)-3-nitrophthalimide

Conditions
ConditionsYield
In acetic acid97%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

5-methylene-4-phenyl-4-vinyl-1,3-dioxolan-2-one

5-methylene-4-phenyl-4-vinyl-1,3-dioxolan-2-one

C18H14F3NO

C18H14F3NO

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; trifuran-2-yl-phosphane In dichloromethane at 20℃; for 12h;97%
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

(E)-methyl undeca-1,4-dien-3-yl carbonate

(E)-methyl undeca-1,4-dien-3-yl carbonate

(Z)-4-(trifluoromethoxy)-N-(undeca-1,3-dien-5-yl)aniline

(Z)-4-(trifluoromethoxy)-N-(undeca-1,3-dien-5-yl)aniline

Conditions
ConditionsYield
With N,N-diisopropyl-2,4,8,10-tetra(naphthalen-2-yl)dibenzo[d,f][1,3,2]dioxaphosphepin-6-amine; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 25℃; for 36h; Schlenk technique; Inert atmosphere; regioselective reaction;97%
6-bromo-4-chloroquinozoline
38267-96-8

6-bromo-4-chloroquinozoline

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

6-bromo-N-(4-(trifluoromethoxy)phenyl)quinazolin-4-amine

6-bromo-N-(4-(trifluoromethoxy)phenyl)quinazolin-4-amine

Conditions
ConditionsYield
In isopropyl alcohol at 90℃; for 4h;96.1%
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