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Jiangsu Huaen Energy Co., Ltd.

Colorless transparent liquid

(Trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(Trifluoromethoxy)benzene Manufacturer/High quality/Best price/In stock

Cas:456-55-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White to beige solid Conform Identification(by IR) Conform

high purity 456-55-3 (Trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:1 Kilogram

FOB Price: $1.9 / 2.5

Type:Trading Company

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (Trifluoromethoxy)Benzene

Cas:456-55-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

Located in Zhengdong New District, Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is comprehensive high-tech modern enterprises integrating professional R&D, production and sales. Strong technical force, with a long-term professio

(Trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (Trifluoromethoxy)Benzene

Cas:456-55-3

Min.Order:1

Negotiable

Type:Other

inquiry

Jinan Finer Chemical Co., Ltd

Product description: Product name Trifluoromethoxybenzene CAS number 456-55-3 Assay ≥99% Appearance Colorless transparent liquid Capacity 500mt/year Application Pharmaceutica

Trifluoromethoxybenzene

Cas:456-55-3

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

(Trifluoromethoxy)Benzene

Cas:456-55-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(Trifluoromethoxy)-benzene

Cas:456-55-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

(trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

456-55-3 (Trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 456-55-3 with best quality

Cas:456-55-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(Trifluoromethoxy)benzene 456-55-3

Cas:456-55-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(Trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(Trifluoromethoxy)Benzene

Cas:456-55-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(Trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(Trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality Appearance:Colorless to light yellow liquid Storage:Keep away of light,cool place Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates Transportation:as per your request Po

Trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

(Trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

(Trifluoromethoxy)benzene Chemical Properties Melting point -49.9°C Boiling point 102 °C(lit.) density 1.226 g/mL at 25 °C(lit.) vapor pressure 41.3 mm Hg ( 25 °C) refractive index n20/D 1.406(lit.) Fp 54 °

Trifluoromethoxubenzene

Cas:456-55-3

Min.Order:200 Kilogram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

(Trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Xi'an yuanfar international trade company

best quality, best price and best service. Appearance:colorless liquid Application:Used in the synthesis of fluorine-containing pesticides, medicine in the middle. Medical drugs synthesized from fluorinated organic compounds have many advantages

low price\high quality99%\(Trifluoromethoxy)Benzene

Cas:456-55-3

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/Trifluoromethoxubenzene

Cas:456-55-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

(Trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Beijing Greenchem Technology Co.,Ltd. ( Panjin Greenchem Technology Co.Ltd .)

Capability on chemical synthesis1. Beijing High-Tech Enterprises2. Strong R&D Team3. 8 years of experiences in R & D of high-tech Catalyst;4. 5000 production techniques, 69 items of national patents, and 360 kinds of products on sales;5. The producti

Trifluoromethoxubenzene

Cas:456-55-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

1-(trifluoromethoxy)benzene cas no. 456-55-3 98%

Cas:456-55-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Best service,high quality and cheap price. Storage:Keep away from heat,sparks and flames. Package:25kg/50kg/200kg drum or Customer demand Application:Used as pharmaceutical intermediates Transportation:BY sea/air or by courier

Trifluoromethoxybenzene

Cas:456-55-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(Trifluoromethoxy)benzene

Cas:456-55-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Trifluoromethoxybenzene

Cas:456-55-3

Min.Order:0

Negotiable

Type:Other

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

(Trifluoromethoxy)Benzene

Cas:456-55-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

(trichloromethoxy)benzene
34888-05-6

(trichloromethoxy)benzene

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
With hydrogen fluoride at 95℃; under 21002.1 Torr; Temperature; Pressure; Autoclave;95.46%
90%
With antimonypentachloride; antimony(III) fluoride
α,α-difluorophenoxyacetic acid
24210-45-5

α,α-difluorophenoxyacetic acid

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
With tetrafluoroboric acid; selectfluor II; silver nitrate In dichloromethane; water at 80℃; for 12h; Reagent/catalyst; Inert atmosphere;84%
With xenon difluoride In chloroform-d1 at 23℃; for 0.0833333h; Inert atmosphere; Sealed tube;39%
With phosphoric acid; silver trifluoromethanesulfonate; Selectfluor In dichloromethane; water at 55℃; for 1h; Catalytic behavior; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; Glovebox;90 %Spectr.
2-(trifluoromethoxy)biphenylyl-2'-diazonium hexafluoroantimonate

2-(trifluoromethoxy)biphenylyl-2'-diazonium hexafluoroantimonate

phenol
108-95-2

phenol

A

dibenzofuran
132-64-9

dibenzofuran

B

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
at 42℃; for 3h;A 78%
B n/a
2-(trifluoromethoxy)biphenylyl-2'-diazonium tetrafluoroborate

2-(trifluoromethoxy)biphenylyl-2'-diazonium tetrafluoroborate

phenol
108-95-2

phenol

A

dibenzofuran
132-64-9

dibenzofuran

B

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
at 42℃; for 3h;A 76%
B n/a
1-chloro-4-(trifluoromethoxy)benzene
461-81-4

1-chloro-4-(trifluoromethoxy)benzene

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
With sodium hydroxide; hydrogen; palladium on activated charcoal In ethanol under 2068.6 Torr; for 5h;74.4%
2-(trifluoromethoxy)biphenylyl-2'-diazonium hexafluorophosphate

2-(trifluoromethoxy)biphenylyl-2'-diazonium hexafluorophosphate

phenol
108-95-2

phenol

A

dibenzofuran
132-64-9

dibenzofuran

B

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
at 42℃; for 3h;A 74%
B n/a
2-(trifluoromethoxy)biphenylyl-2'-diazonium triflate

2-(trifluoromethoxy)biphenylyl-2'-diazonium triflate

phenol
108-95-2

phenol

A

dibenzofuran
132-64-9

dibenzofuran

B

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
at 42℃; for 3h;A 74%
B n/a
tetrachloromethane
56-23-5

tetrachloromethane

phenol
108-95-2

phenol

A

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

B

aurin
603-45-2

aurin

Conditions
ConditionsYield
With hydrogen fluorideA 31%
B 69%
Bis-(trifluormethyl)-bis-(trifluormethoxy)-sulfuran
63465-11-2

Bis-(trifluormethyl)-bis-(trifluormethoxy)-sulfuran

phenol
108-95-2

phenol

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
In diethyl ether 25°C, 0.5 h;53%
S-(trifluoromethyl)-3,7-dinitrodibenzothiophenium trifluoromethanesulfonate
129922-37-8

S-(trifluoromethyl)-3,7-dinitrodibenzothiophenium trifluoromethanesulfonate

phenol
108-95-2

phenol

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
at 80℃; for 1.5h;13%
difluorochloromethoxybenzene
770-11-6

difluorochloromethoxybenzene

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
With antimonypentachloride; antimony(III) fluoride
4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
With hypophosphoric acid Diazotization;
hypofluorous acid trifluoromethyl ester
373-91-1

hypofluorous acid trifluoromethyl ester

benzene
71-43-2

benzene

A

fluorobenzene
462-06-6

fluorobenzene

B

para-difluorobenzene
540-36-3

para-difluorobenzene

C

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
In dichloromethane at 0℃; Title compound not separated from byproducts;A 39 % Chromat.
B 2 % Chromat.
C 2 % Chromat.
benzene
71-43-2

benzene

A

fluorobenzene
462-06-6

fluorobenzene

B

para-difluorobenzene
540-36-3

para-difluorobenzene

C

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
With hypofluorous acid trifluoromethyl ester In dichloromethane at 0℃; Product distribution; other sub. aromatic hydrocarbons and anilines; other solvents and temp.;
With hypofluorous acid trifluoromethyl ester In dichloromethane at 0℃; Title compound not separated from byproducts;A 39 % Chromat.
B 2 % Chromat.
C 2 % Chromat.
hypofluorous acid trifluoromethyl ester
373-91-1

hypofluorous acid trifluoromethyl ester

benzene
71-43-2

benzene

nitrogen

nitrogen

A

fluorobenzene
462-06-6

fluorobenzene

B

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

(trichloromethoxy)benzene
34888-05-6

(trichloromethoxy)benzene

A

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

B

difluorochloromethoxybenzene
770-11-6

difluorochloromethoxybenzene

Conditions
ConditionsYield
With hydrogen fluoride; antimonypentachloride at 50℃; under 7500.6 Torr; for 1h; Product distribution; Further Variations:; Reagents; Temperatures; time;
With hydrogen fluoride; antimonypentachloride at 50℃; under 7500.75 Torr; for 1h; Inert atmosphere; Autoclave;
5-tert-butyl-2'-(trifluoromethoxy)biphenylyl-2-diazonium hexafluoroantimonate

5-tert-butyl-2'-(trifluoromethoxy)biphenylyl-2-diazonium hexafluoroantimonate

phenol
108-95-2

phenol

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
Stage #1: 5-tert-butyl-2'-(trifluoromethoxy)biphenylyl-2-diazonium hexafluoroantimonate In dichloromethane at -100 - -90℃; for 1.16667h; Irradiation;
Stage #2: phenol With N-ethyl-N,N-diisopropylamine In dichloromethane at -90 - -10℃; for 3h; Further stages.;
4-chloro-phenol
106-48-9

4-chloro-phenol

KOH-solution

KOH-solution

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 60.7 percent / HF / 150 °C / several hours
2: 74.4 percent / H2, NaOH / 10percent Pd/C / ethanol / 5 h / 2068.6 Torr
View Scheme
dichloro-phenoxy-methanesulfenyl chloride
98273-25-7

dichloro-phenoxy-methanesulfenyl chloride

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chlorine
2: antimony (III)-fluoride; antimony (V)-chloride
View Scheme
Multi-step reaction with 3 steps
1: chlorine
2: antimony (III)-fluoride
3: antimony (III)-fluoride; antimony (V)-chloride
View Scheme
phenylcarbonochloridothioate
1005-56-7

phenylcarbonochloridothioate

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chlorine
2: chlorine
3: antimony (III)-fluoride; antimony (V)-chloride
View Scheme
Multi-step reaction with 4 steps
1: chlorine
2: chlorine
3: antimony (III)-fluoride
4: antimony (III)-fluoride; antimony (V)-chloride
View Scheme
1,3-dichloro-4-(trifluoromethoxy)benzene
451-85-4

1,3-dichloro-4-(trifluoromethoxy)benzene

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

2-(dimethylamino)-1,3-dimethylimidazolidin-2-ylium trifluoromethanolate
1006904-71-7

2-(dimethylamino)-1,3-dimethylimidazolidin-2-ylium trifluoromethanolate

2-(trimethylsilyl)phenyl trifluoromethanesulfonate
88284-48-4

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

A

fluorobenzene
462-06-6

fluorobenzene

B

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Conditions
ConditionsYield
In diethyl ether; acetonitrile at 0 - 20℃; Title compound not separated from byproducts.;
phenyl trifluoromethylsulfide
456-56-4

phenyl trifluoromethylsulfide

A

(trifluoromethylsulfonyl)benzene
426-58-4

(trifluoromethylsulfonyl)benzene

B

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

bis(trifluoromethyl)bis(trifluoromethoxy)oxosulfur(VI)
66632-46-0

bis(trifluoromethyl)bis(trifluoromethoxy)oxosulfur(VI)

phenol
108-95-2

phenol

A

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

B

bis(trifluoromethyl)sulfone
72971-96-1

bis(trifluoromethyl)sulfone

Conditions
ConditionsYield
In diethyl ether 25°C, 0.5 h;
bromochlorobenzene
106-39-8

bromochlorobenzene

1-bromo-4-(trifluoromethoxy)benzene
407-14-7

1-bromo-4-(trifluoromethoxy)benzene

A

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

B

chlorobenzene
108-90-7

chlorobenzene

Conditions
ConditionsYield
Stage #1: bromochlorobenzene; 1-bromo-4-(trifluoromethoxy)benzene With TurboGrignard In tetrahydrofuran at 0℃;
Stage #2: With methanol In tetrahydrofuran Reactivity;
1-bromo-3-chlorobenzene
108-37-2

1-bromo-3-chlorobenzene

1-bromo-3-(trifluoromethoxy)benzene
2252-44-0

1-bromo-3-(trifluoromethoxy)benzene

A

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

B

chlorobenzene
108-90-7

chlorobenzene

Conditions
ConditionsYield
Stage #1: 1-bromo-3-chlorobenzene; 1-bromo-3-(trifluoromethoxy)benzene With TurboGrignard In tetrahydrofuran at 0℃;
Stage #2: With methanol In tetrahydrofuran Reactivity;
1-bromo-3-chlorobenzene
108-37-2

1-bromo-3-chlorobenzene

1-bromo-4-(trifluoromethoxy)benzene
407-14-7

1-bromo-4-(trifluoromethoxy)benzene

A

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

B

chlorobenzene
108-90-7

chlorobenzene

Conditions
ConditionsYield
Stage #1: 1-bromo-3-chlorobenzene; 1-bromo-4-(trifluoromethoxy)benzene With TurboGrignard In tetrahydrofuran at 0℃;
Stage #2: With methanol In tetrahydrofuran Reactivity;
2-bromo-1-chlorobenzene
694-80-4

2-bromo-1-chlorobenzene

1-bromo-2-(trifluoromethoxy)benzene
64115-88-4

1-bromo-2-(trifluoromethoxy)benzene

A

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

B

chlorobenzene
108-90-7

chlorobenzene

Conditions
ConditionsYield
Stage #1: 2-bromo-1-chlorobenzene; 1-bromo-2-(trifluoromethoxy)benzene With TurboGrignard In tetrahydrofuran at 0℃;
Stage #2: With methanol In tetrahydrofuran Reactivity;
1-bromo-3-(trifluoromethoxy)benzene
2252-44-0

1-bromo-3-(trifluoromethoxy)benzene

4-bromobenzenecarbonitrile
623-00-7

4-bromobenzenecarbonitrile

A

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

B

benzonitrile
100-47-0

benzonitrile

Conditions
ConditionsYield
Stage #1: 1-bromo-3-(trifluoromethoxy)benzene; 4-bromobenzenecarbonitrile With TurboGrignard In tetrahydrofuran at 0℃;
Stage #2: With methanol In tetrahydrofuran Reactivity;
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

1-iodo-2-(trifluoromethoxy)benzene
175278-00-9

1-iodo-2-(trifluoromethoxy)benzene

Conditions
ConditionsYield
Stage #1: 1-trifluoromethoxybenzene With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tetrahydrofuran
Stage #2: With iodine In tetrahydrofuran
99%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

A

(trichloromethoxy)benzene
34888-05-6

(trichloromethoxy)benzene

B

α,α,α-dichlorofluoromethoxybenzene
1544-69-0

α,α,α-dichlorofluoromethoxybenzene

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane at 0 - 10℃; for 0.5h;A 98.2%
B 1.8%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

4-(trifluoromethoxy)aniline
461-82-5

4-(trifluoromethoxy)aniline

Conditions
ConditionsYield
Stage #1: 1-trifluoromethoxybenzene With sodium ferrate(VI); sodium bromide In dimethyl sulfoxide at 95℃; for 4h; Inert atmosphere;
Stage #2: With sodium amide In dimethyl sulfoxide at 155℃; under 3040.2 Torr; for 10h; Solvent; Temperature; Reagent/catalyst; Pressure; Inert atmosphere;
98.2%
Multi-step reaction with 2 steps
1: sulfuric acid; nitric acid / dichloromethane / 2 h / 0 - 30 °C
2: iron; hydrogenchloride / methanol / 2 h / 60 - 65 °C
View Scheme
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

trifluoromethoxy-4 phenyl, methyl-4' phenyl sulfone
87750-49-0

trifluoromethoxy-4 phenyl, methyl-4' phenyl sulfone

Conditions
ConditionsYield
With hydrogen fluoride; boron trifluoride at 20℃; for 23h;94%
With potassium hydroxide; HF In water94%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2-(trifluoromethoxy)benzaldehyde
94651-33-9

2-(trifluoromethoxy)benzaldehyde

Conditions
ConditionsYield
Stage #1: 1-trifluoromethoxybenzene With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tetrahydrofuran; cyclohexane at -75℃; for 2h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; cyclohexane at -75℃; Further stages.;
93%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

trifluoromethoxy-4 fluoro-4' benzophenone
87996-56-3

trifluoromethoxy-4 fluoro-4' benzophenone

Conditions
ConditionsYield
With hydrogen fluoride; boron trifluoride at 20℃; for 2h;92%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

(4-chlorophenyl)(4-(trifluoromethoxy)phenyl)methanone
87996-55-2

(4-chlorophenyl)(4-(trifluoromethoxy)phenyl)methanone

Conditions
ConditionsYield
With hydrogen fluoride; boron trifluoride at 10℃; for 3h;92%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

acetyl chloride
75-36-5

acetyl chloride

1-[4-(trifluoromethoxy)phenyl]ethan-1-one
85013-98-5

1-[4-(trifluoromethoxy)phenyl]ethan-1-one

Conditions
ConditionsYield
With hydrogen fluoride; boron trifluoride at 20℃; for 3h; further acid chlorides;91%
With hydrogen fluoride; boron trifluoride at 20℃; for 3h;91%
With iron(III) chloride In nitromethane for 1h; Product distribution; Ambient temperature; investigation of the acetylation reaction; relative reactivity data compared to benzene;100 % Chromat.
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

2-trifluoromethylbenzoyl chloride
312-94-7

2-trifluoromethylbenzoyl chloride

trifluoromethoxy-4 trifluoromethyl-2' benzophenone
87996-57-4

trifluoromethoxy-4 trifluoromethyl-2' benzophenone

Conditions
ConditionsYield
With hydrogen fluoride; boron trifluoride at 30℃; for 2h;91%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

4-trifluoromethyl-phenyl acetyl chloride
329-15-7

4-trifluoromethyl-phenyl acetyl chloride

trifluoromethoxy-4 trifluoromethyl-4' benzophenone
34367-37-8

trifluoromethoxy-4 trifluoromethyl-4' benzophenone

Conditions
ConditionsYield
With hydrogen fluoride; boron trifluoride at 30℃; for 4h;90%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

isobutyryl chloride
79-30-1

isobutyryl chloride

2-methyl-1-(4-(trifluoromethoxy)phenyl)propan-1-one
56425-84-4

2-methyl-1-(4-(trifluoromethoxy)phenyl)propan-1-one

Conditions
ConditionsYield
With hydrogen fluoride; boron trifluoride at 0℃; for 5h;90%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

o-chlorobenzoyl chloride
609-65-4

o-chlorobenzoyl chloride

trifluoromethoxy-4 chloro-2' benzophenone
87996-54-1

trifluoromethoxy-4 chloro-2' benzophenone

Conditions
ConditionsYield
With hydrogen fluoride; boron trifluoride at 20℃; for 1h;89%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

2-trifluoromethoxyphenylboronic acid
175676-65-0

2-trifluoromethoxyphenylboronic acid

Conditions
ConditionsYield
Stage #1: 1-trifluoromethoxybenzene With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tetrahydrofuran; cyclohexane at -75℃; for 2h;
Stage #2: With fluorodimethoxyborane diethyl etherate In tetrahydrofuran; cyclohexane at -75℃;
Stage #3: With water In tetrahydrofuran; cyclohexane for 0.5h; Further stages.;
89%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

2-(trifluoromethoxy)phenol
32858-93-8

2-(trifluoromethoxy)phenol

Conditions
ConditionsYield
Stage #1: 1-trifluoromethoxybenzene With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tetrahydrofuran; cyclohexane at -75℃; for 2h;
Stage #2: With fluorodimethoxyborane diethyl etherate In tetrahydrofuran; cyclohexane at -75℃;
Stage #3: With sodium hydroxide; dihydrogen peroxide In tetrahydrofuran; cyclohexane Further stages.;
88%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

ethyl 2-oxo-2-[2-(trifluoromethoxy)phenyl]acetate

ethyl 2-oxo-2-[2-(trifluoromethoxy)phenyl]acetate

Conditions
ConditionsYield
Stage #1: 1-trifluoromethoxybenzene With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tetrahydrofuran; cyclohexane at -75℃; for 2h;
Stage #2: Ethyl oxalyl chloride In tetrahydrofuran; cyclohexane at -75℃; Further stages.;
87%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

1-ethoxy-2,2-difluoroethanol
148992-43-2

1-ethoxy-2,2-difluoroethanol

1,1-difluoro-2,2-bis[p-(trifluoromethoxy)benzene]ethane
1314534-88-7

1,1-difluoro-2,2-bis[p-(trifluoromethoxy)benzene]ethane

Conditions
ConditionsYield
With boron trifluoride monohydrate In water at 0℃; for 1h; Friedel Crafts hydroxyalkylation;86%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

4-nitrophenyl trifluoromethyl ether
713-65-5

4-nitrophenyl trifluoromethyl ether

Conditions
ConditionsYield
With sulfuric acid; nitric acid In dichloromethane at 0 - 30℃; for 2h;85%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

1-bromo-4-(trifluoromethoxy)benzene
407-14-7

1-bromo-4-(trifluoromethoxy)benzene

Conditions
ConditionsYield
With bromine; iron at 100℃; for 16h;83.8%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

4-dimethylaminophenylmagnesium bromide
7353-91-5

4-dimethylaminophenylmagnesium bromide

N,N-dimethyl-4-biphenylamine
1137-79-7

N,N-dimethyl-4-biphenylamine

Conditions
ConditionsYield
With C68H72Cl2N6NiP2 In toluene at 120℃; for 16h; Inert atmosphere;83%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

Langlois reagent
2926-29-6

Langlois reagent

1-trifluoromethanesulfinyl-4-trifluoromethoxy-benzene

1-trifluoromethanesulfinyl-4-trifluoromethoxy-benzene

Conditions
ConditionsYield
With trifluoromethylsulfonic anhydride at 20℃;82%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

m-Chlorobenzoyl chloride
618-46-2

m-Chlorobenzoyl chloride

(3-chlorophenyl)(2-trifluoromethoxyphenyl)methanone
1146289-22-6

(3-chlorophenyl)(2-trifluoromethoxyphenyl)methanone

Conditions
ConditionsYield
Stage #1: 1-trifluoromethoxybenzene With aluminum tris-(tert-butyl-(1-isopropyl-2,2-dimethyl-propyl)amide)-tris(lithium chloride) In tetrahydrofuran at 0℃; for 3h; Inert atmosphere;
Stage #2: With zinc(II) chloride In tetrahydrofuran at -30℃; for 0.25h; Inert atmosphere;
Stage #3: m-Chlorobenzoyl chloride With copper(I) cyanide*2 lithium chloride In tetrahydrofuran at -30 - 25℃; Inert atmosphere; regioselective reaction;
81%
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

acetyl chloride
75-36-5

acetyl chloride

A

(trichloromethoxy)benzene
34888-05-6

(trichloromethoxy)benzene

B

1-[4-(trifluoromethoxy)phenyl]ethan-1-one
85013-98-5

1-[4-(trifluoromethoxy)phenyl]ethan-1-one

Conditions
ConditionsYield
With aluminium trichloride In tetrachloromethane for 2h; Product distribution; Further Variations:; Solvents;A 80%
B 20%
5-decyne
1942-46-7

5-decyne

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

1,2,3,4-tetrabutyl-6-(trifluoromethoxy)naphthalene
1613114-49-0

1,2,3,4-tetrabutyl-6-(trifluoromethoxy)naphthalene

Conditions
ConditionsYield
With copper(II) 2-ethylhexanoate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; 2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether at 160℃; for 3h; Inert atmosphere; Microwave irradiation;80%
triethylsilane
617-86-7

triethylsilane

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

A

triethylsilyl fluoride
358-43-0

triethylsilyl fluoride

B

methoxybenzene
100-66-3

methoxybenzene

Conditions
ConditionsYield
With C21H16N3P(2+) In dichloromethane at 50℃; for 96h; Reagent/catalyst;A 80%
B n/a
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

A

4-nitrophenyl trifluoromethyl ether
713-65-5

4-nitrophenyl trifluoromethyl ether

B

o-nitro-α,α,α-trifluoromethoxybenzene
1644-88-8

o-nitro-α,α,α-trifluoromethoxybenzene

Conditions
ConditionsYield
With magnesium(II) perchlorate; N–nitrosaccharin In [D3]acetonitrile at 85℃; for 19h; Inert atmosphere; Sealed tube; Overall yield = 97 percent;A 79.7%
B 17.3%
With nitronium tetrafluoborate In nitromethane at 25℃; for 2h; Product distribution; further nitrating reagents, solvents and temperature; investigation of the nitration reaction; Hammett-Brown plot (relative reactivity data compared to benzene);A 88.5 % Chromat.
B 11.5 % Chromat.
With sulfuric acid; nitric acid at -0.16℃; Temperature; Flow reactor;A 90.97 %Chromat.
B 7.26 %Chromat.
carbon dioxide
124-38-9

carbon dioxide

1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

2-(trifluoromethoxy)benzoic acid
1979-29-9

2-(trifluoromethoxy)benzoic acid

Conditions
ConditionsYield
Stage #1: 1-trifluoromethoxybenzene With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tetrahydrofuran; cyclohexane at -75℃; for 2h;
Stage #2: carbon dioxide In tetrahydrofuran; cyclohexane at -78℃; Further stages.;
78%
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