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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Hinokitiol 499-44-5 ISO Manufacturer

Cas:499-44-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Minstar Chemical Co., Ltd

Hinokitiol Basic information Product Name: Hinokitiol Synonyms: HINOKITIOL;BETA-THUJAPLICIN;BETA-THUJAPLICINE;B-THUJAPLICIN;2-HYDROXY-4-ISOPROPYLCYCLOHEPTA-2,4,6-TRIEN-1-ONE;2-HYDROXY-4-ISOPROPYL-2,4,6-CYCLOHEPTATRIEN-1-ONE;2-HYDROXY-4-ISOPROPYL-2,4

Hinokitiol

Cas:499-44-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Jinan Finer Chemical Co., Ltd

Product Description Product Name

Hinokitiol

Cas:499-44-5

Min.Order:1 Kilogram

FOB Price: $15.0 / 20.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Hinokitiol Manufacturer/High quality/Best price/In stock

Cas:499-44-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Analysis tests Standard Results Appearance Yellowish Crystallization Hangzhou Dingyan Chem is a leading manufacturer and supplie

High quality Hinokitiol with best price cas:499-44-5

Cas:499-44-5

Min.Order:1 Kilogram

FOB Price: $250.0 / 350.0

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Hinokitiol supplier in China

Cas:499-44-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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shanghai Tauto Biotech Co., Ltd

18-year experience in Phytochemicals Each product has passed very strict tests (NMR\MS\HPLC) Agents in 13 countries Certified by ISO 9001:2008 quality management system Leader Supplier of Botanical Reference Materials in China

Hinokitiol

Cas:499-44-5

Min.Order:10 Milligram

Negotiable

Type:Manufacturers

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

High purity API wholesale Hinokitiol Sanitizer Powder CAS:499-44-5

Cas:499-44-5

Min.Order:100 Gram

FOB Price: $0.9 / 2.8

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Hinokitiol

Cas:499-44-5

Min.Order:1

Negotiable

Type:Other

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Hinokitiol

Cas:499-44-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Hinokitiol

Cas:499-44-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Hot Product Plant Extract Hinokitiol CAS 499-44-5

Cas:499-44-5

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Hinokitiol Basic information Product Name: Hinokitiol Synonyms: HINOKITIOL;BETA-THUJAPLICIN;BETA-THUJAPLICINE;B-THUJAPLICIN;2-HYDROXY-4-ISOPROPYLCYCLOHEPTA-2,4,6-TRIEN-1-ONE;2-HYDROXY-4-

Hinokitiol 499-44-5

Cas:499-44-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 499-44-5 with best quality

Cas:499-44-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Hinokitiol Symonyms 2-Hydroxy-4-isopropyl-cyclohepta-2,4,6-trien-1-one CAS No.

Hinokitiol

Cas:499-44-5

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:R T Package:25kg/Barrel Application:It has good antibacterial, moisturizing and pest avoidance effect, is a high-safety plant ingredient, can be used as an antibacterial, insect repellent, is the main component of Tai

High Quality Hinokitiol

Cas:499-44-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Hinokitiol CAS NO 499-44-5

Cas:499-44-5

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2,4,6-Cycloheptatrien-1-one,2-hydroxy-4-(1-methylethyl)- 499-44-5

Cas:499-44-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Faithful Pure Hinokitiol / β-thujaplicin / BETA-THUJAPLICIN 100% Safe Customs Clearance

Cas:499-44-5

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Hinokitiol 99%

Cas:499-44-5

Min.Order:1 Kilogram

FOB Price: $85.0 / 98.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Hinokitiol CAS:499-44-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Hinokitiol CAS:499-44-5

Cas:499-44-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2,4,6-Cycloheptatrien-1-one,2-hydroxy-4-(1-methylethyl)-

Cas:499-44-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:499-44-5

Cas:499-44-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Leader Biochemical Group

PRODUCT DETAILS Hinokitiol Basic information Chemical Properties benefits Safety

ISO.HACCP.GMP.FDA.SGS.BV-China Largest Manufacturer factory Supply Hinokitiol CAS 499-44-5

Cas:499-44-5

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

beta-thujaplicin 499-44-5

Cas:499-44-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Hinokitiol CAS 499-44-5

Cas:499-44-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Hinokitiol

Cas:499-44-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

Hinokitiol CAS 499-44-5 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Prof

Hinokitiol CAS 499-44-5

Cas:499-44-5

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

advantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packaging

Best price/In stock Hinokitiol 499-44-5

Cas:499-44-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hefei Zhaobo Technology Co., Ltd.

Hinokitiol CAS 499-44-5 Description Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality c

Hinokitiol CAS 499-44-5

Cas:499-44-5

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Synthetic route

2-amino-6-isopropyl-cycloheptatrienone
55076-49-8

2-amino-6-isopropyl-cycloheptatrienone

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
With potassium hydroxide100%
β-dolabrin
4570-11-0

β-dolabrin

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol at 22℃; under 760 Torr; for 6.5h;98%
With hydrogen; palladium on activated charcoal In ethanol98%
isopropanol boric acid
52732-22-6

isopropanol boric acid

2-hydroxy-4-chloro-2,4,6-cycloheptatrien-1-one
698-48-6

2-hydroxy-4-chloro-2,4,6-cycloheptatrien-1-one

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
With potassium phosphate In tetrahydrofuran at 100℃; for 2h;97.5%
(5S)-6-isopropyl-3-cycloheptene-1,2-dione
310905-95-4

(5S)-6-isopropyl-3-cycloheptene-1,2-dione

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
Stage #1: (5S)-6-isopropyl-3-cycloheptene-1,2-dione With pyrrolidone hydrotribromide In tetrahydrofuran at 20℃; for 1h; Bromination;
Stage #2: With lithium carbonate; lithium bromide In N,N-dimethyl-formamide for 2h; Aromatisation; Heating;
71%
4-bromo-2-hydroxycycklohepta-2,4,6-trien-1-one
698-47-5

4-bromo-2-hydroxycycklohepta-2,4,6-trien-1-one

isopropenyltrimethylstannane
3043-46-7

isopropenyltrimethylstannane

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
Stage #1: 4-bromo-2-hydroxycycklohepta-2,4,6-trien-1-one; isopropenyltrimethylstannane With bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane for 1h; Reflux;
Stage #2: With 5%-palladium/activated carbon; hydrogen In ethanol at 20℃; under 760.051 Torr; for 24h;
53%
4-isopropyl-cycloheptanone
13656-84-3

4-isopropyl-cycloheptanone

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
With selenium(IV) oxide; ethanol Erwaermen des Reaktionsprodukts mit N-Brom-succinimid in CHCl3;
4-isopropyl-cycloheptanone
13656-84-3

4-isopropyl-cycloheptanone

A

hinokitiol
499-44-5

hinokitiol

B

3-bromo-5-isopropyl-tropolone
2891-67-0

3-bromo-5-isopropyl-tropolone

Conditions
ConditionsYield
With selenium(IV) oxide; ethanol Behandeln des Reaktionsprodukts mit Brom in Essigsaeure und Erhitzen des hierbei erhaltenen Reaktionsprodukts mit Wasserdampf;
3-isopropylcycloheptanone
108168-72-5

3-isopropylcycloheptanone

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
With selenium(IV) oxide; ethanol Erwaermen des Reaktionsprodukts mit N-Brom-succinimid in CHCl3;
Multi-step reaction with 2 steps
1: selenium dioxide / ethanol; H2O / 2 h / 90 °C
2: 1.) phenyltrimethylammonium tribromide 2.) LiCl, Li2CO3 / 1.) THF, RT, 1.75 h, 2.) DMF, 120 deg C, 45 min
View Scheme
(1S,5R)-7,7-Dichloro-1-isopropyl-bicyclo[3.2.0]hept-2-en-6-one

(1S,5R)-7,7-Dichloro-1-isopropyl-bicyclo[3.2.0]hept-2-en-6-one

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
With potassium acetate
(1R,5S)-7,7-Dichloro-3-isopropyl-bicyclo[3.2.0]hept-2-en-6-one

(1R,5S)-7,7-Dichloro-3-isopropyl-bicyclo[3.2.0]hept-2-en-6-one

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
With potassium acetate
2-hydroxy-6-isopropyl-2,4,6-cycloheptatrien-1-one
499-44-5

2-hydroxy-6-isopropyl-2,4,6-cycloheptatrien-1-one

A

(Z)-Cyclooctene
931-88-4, 931-87-3

(Z)-Cyclooctene

B

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
In decalin at 180℃; for 4h;A 95 % Spectr.
B n/a
2-hydroxy-6-isopropyl-2,4,6-cycloheptatrien-1-one
499-44-5

2-hydroxy-6-isopropyl-2,4,6-cycloheptatrien-1-one

A

hinokitiol
499-44-5

hinokitiol

B

cyclopentene
142-29-0

cyclopentene

Conditions
ConditionsYield
In decalin at 180℃; for 3h;A n/a
B 95 % Spectr.
4-isopropylcycloheptane-1,2-dione
108168-73-6

4-isopropylcycloheptane-1,2-dione

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
With C6H5N(1+); lithium chloride Yield given. Multistep reaction;
With phenyltrimethylammonium tribromide; lithium carbonate; lithium chloride 1.) THF, RT, 1.75 h, 2.) DMF, 120 deg C, 45 min; Yield given. Multistep reaction;
2-chloro-6-isopropyl-cycloheptatrienone
66967-15-5

2-chloro-6-isopropyl-cycloheptatrienone

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
With phosphoric acid; acetic acid
2-chloro-5-isopropyltropone
66967-10-0

2-chloro-5-isopropyltropone

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
With phosphoric acid; acetic acid Heating;
/PBWLC126-1000/

/PBWLC126-1000/

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
oxidation;
(R)-3-(1-methylethyl)-6-oxoheptanal dimethylacetal
105897-85-6

(R)-3-(1-methylethyl)-6-oxoheptanal dimethylacetal

A

hinokitiol
499-44-5

hinokitiol

B

2-bromoprop-2-enyl halide

2-bromoprop-2-enyl halide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -15 - 0 °C
1.2: tetrahydrofuran; hexane / 2 h / -78 - 20 °C
2.1: TiCl4 / CH2Cl2 / 0.17 h / -78 °C
3.1: 63 percent / p-TsOH; 4 Angstroem molecular sieves / benzene / 1 h / Heating
4.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -15 - 0 °C
4.2: tetrahydrofuran; hexane / 0.5 h / -15 - 20 °C
5.1: MCPBA / hexane / 4 h / 20 °C
5.2: 0.8 g / Et3N*3HF / CH2Cl2 / 2 h / 20 °C
6.1: 88 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
7.1: pyrrolidone hydrotribromide / tetrahydrofuran / 1 h / 20 °C
7.2: 71 percent / LiBr; Li2CO3 / dimethylformamide / 2 h / Heating
View Scheme
(5R)-5-isopropyl-2-cyclohepten-1-one
310905-92-1

(5R)-5-isopropyl-2-cyclohepten-1-one

A

hinokitiol
499-44-5

hinokitiol

B

2-bromoprop-2-enyl halide

2-bromoprop-2-enyl halide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -15 - 0 °C
1.2: tetrahydrofuran; hexane / 0.5 h / -15 - 20 °C
2.1: MCPBA / hexane / 4 h / 20 °C
2.2: 0.8 g / Et3N*3HF / CH2Cl2 / 2 h / 20 °C
3.1: 88 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
4.1: pyrrolidone hydrotribromide / tetrahydrofuran / 1 h / 20 °C
4.2: 71 percent / LiBr; Li2CO3 / dimethylformamide / 2 h / Heating
View Scheme
(5S)-7-hydroxy-5-isopropyl-2-cyclohepten-1-one
310905-94-3

(5S)-7-hydroxy-5-isopropyl-2-cyclohepten-1-one

A

hinokitiol
499-44-5

hinokitiol

B

2-bromoprop-2-enyl halide

2-bromoprop-2-enyl halide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 88 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
2.1: pyrrolidone hydrotribromide / tetrahydrofuran / 1 h / 20 °C
2.2: 71 percent / LiBr; Li2CO3 / dimethylformamide / 2 h / Heating
View Scheme
(5R)-5-isopropyl-3-methoxycycloheptanone
310905-91-0

(5R)-5-isopropyl-3-methoxycycloheptanone

A

hinokitiol
499-44-5

hinokitiol

B

2-bromoprop-2-enyl halide

2-bromoprop-2-enyl halide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 63 percent / p-TsOH; 4 Angstroem molecular sieves / benzene / 1 h / Heating
2.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -15 - 0 °C
2.2: tetrahydrofuran; hexane / 0.5 h / -15 - 20 °C
3.1: MCPBA / hexane / 4 h / 20 °C
3.2: 0.8 g / Et3N*3HF / CH2Cl2 / 2 h / 20 °C
4.1: 88 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
5.1: pyrrolidone hydrotribromide / tetrahydrofuran / 1 h / 20 °C
5.2: 71 percent / LiBr; Li2CO3 / dimethylformamide / 2 h / Heating
View Scheme
((S)-4-Isopropyl-cyclohepta-1,6-dienyloxy)-trimethyl-silane
310905-93-2

((S)-4-Isopropyl-cyclohepta-1,6-dienyloxy)-trimethyl-silane

A

hinokitiol
499-44-5

hinokitiol

B

2-bromoprop-2-enyl halide

2-bromoprop-2-enyl halide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: MCPBA / hexane / 4 h / 20 °C
1.2: 0.8 g / Et3N*3HF / CH2Cl2 / 2 h / 20 °C
2.1: 88 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
3.1: pyrrolidone hydrotribromide / tetrahydrofuran / 1 h / 20 °C
3.2: 71 percent / LiBr; Li2CO3 / dimethylformamide / 2 h / Heating
View Scheme
[(R)-4-(2,2-Dimethoxy-ethyl)-5-methyl-1-methylene-hexyloxy]-trimethyl-silane
310905-90-9

[(R)-4-(2,2-Dimethoxy-ethyl)-5-methyl-1-methylene-hexyloxy]-trimethyl-silane

A

hinokitiol
499-44-5

hinokitiol

B

2-bromoprop-2-enyl halide

2-bromoprop-2-enyl halide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: TiCl4 / CH2Cl2 / 0.17 h / -78 °C
2.1: 63 percent / p-TsOH; 4 Angstroem molecular sieves / benzene / 1 h / Heating
3.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -15 - 0 °C
3.2: tetrahydrofuran; hexane / 0.5 h / -15 - 20 °C
4.1: MCPBA / hexane / 4 h / 20 °C
4.2: 0.8 g / Et3N*3HF / CH2Cl2 / 2 h / 20 °C
5.1: 88 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
6.1: pyrrolidone hydrotribromide / tetrahydrofuran / 1 h / 20 °C
6.2: 71 percent / LiBr; Li2CO3 / dimethylformamide / 2 h / Heating
View Scheme
4-bromo-2-hydroxycycklohepta-2,4,6-trien-1-one
698-47-5

4-bromo-2-hydroxycycklohepta-2,4,6-trien-1-one

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 54 percent / dichlorobis(triphenylphosphine)palladium(II) / dioxane / 1.3 h / Heating
2: 98 percent / hydrogen / 5percent Pd/C / ethanol
View Scheme
Multi-step reaction with 2 steps
1: 54 percent / dichlorobis(triphenylphosphine)palladium(II) / dioxane / 1.33 h / Heating
2: 98 percent / H2 / 5percent Pd/C / ethanol / 6.5 h / 22 °C / 760 Torr
View Scheme
3-Methoxycyclohepta-1,3,5-triene
1714-40-5

3-Methoxycyclohepta-1,3,5-triene

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Et4NOTs / dimethylformamide / electroreduction
2: 1.) pyridinium bromide perbromide 2.) LiCl/LiCO3 / 2.) DMF
3: 100 percent / NH2NH2
4: 100 percent / KOH
View Scheme
Multi-step reaction with 5 steps
1: Et4NOTs / dimethylformamide / electroreduction
2: 87 percent / aq. H2SO4 / tetrahydrofuran
3: 82 percent / 30percent H2O2/NaOH
4: 72 percent / aq. HCl
5: 1.) C6H5N(1+) 2.) LiCl/LiCO3
View Scheme
1-methoxycyclohepta-1,3,5-triene
1728-32-1

1-methoxycyclohepta-1,3,5-triene

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
2: 1.) pyridinium bromide perbromide 2.) LiCl/LiCO3 / 2.) DMF
3: 100 percent / NH2NH2
4: 100 percent / KOH
View Scheme
Multi-step reaction with 5 steps
2: 87 percent / aq. H2SO4 / tetrahydrofuran
3: 82 percent / 30percent H2O2/NaOH
4: 72 percent / aq. HCl
5: 1.) C6H5N(1+) 2.) LiCl/LiCO3
View Scheme
Multi-step reaction with 4 steps
1: Et4NOTs / dimethylformamide / electroreduction
2: 1.) pyridinium bromide perbromide 2.) LiCl/LiCO3 / 2.) DMF
3: 100 percent / NH2NH2
4: 100 percent / KOH
View Scheme
Multi-step reaction with 5 steps
1: Et4NOTs / dimethylformamide / electroreduction
2: 87 percent / aq. H2SO4 / tetrahydrofuran
3: 82 percent / 30percent H2O2/NaOH
4: 72 percent / aq. HCl
5: 1.) C6H5N(1+) 2.) LiCl/LiCO3
View Scheme
β-isopropyltropolone
35193-01-2

β-isopropyltropolone

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / NH2NH2
2: 100 percent / KOH
View Scheme
6-Isopropyl-cyclohept-3-enone

6-Isopropyl-cyclohept-3-enone

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 82 percent / 30percent H2O2/NaOH
2: 72 percent / aq. HCl
3: 1.) C6H5N(1+) 2.) LiCl/LiCO3
View Scheme
1-methoxy-6-isopropyl-1,3-cycloheptadiene
133826-10-5

1-methoxy-6-isopropyl-1,3-cycloheptadiene

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) pyridinium bromide perbromide 2.) LiCl/LiCO3 / 2.) DMF
2: 100 percent / NH2NH2
3: 100 percent / KOH
View Scheme
Multi-step reaction with 4 steps
1: 87 percent / aq. H2SO4 / tetrahydrofuran
2: 82 percent / 30percent H2O2/NaOH
3: 72 percent / aq. HCl
4: 1.) C6H5N(1+) 2.) LiCl/LiCO3
View Scheme
4-Isopropyl-8-oxa-bicyclo[5.1.0]octan-2-one

4-Isopropyl-8-oxa-bicyclo[5.1.0]octan-2-one

hinokitiol
499-44-5

hinokitiol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / aq. HCl
2: 1.) C6H5N(1+) 2.) LiCl/LiCO3
View Scheme
hinokitiol
499-44-5

hinokitiol

2-hydroxy-7-iodo-4-isopropyltropone
32659-57-7

2-hydroxy-7-iodo-4-isopropyltropone

Conditions
ConditionsYield
With sulfuric acid; iodine; potassium carbonate In chloroform100%
With iodine; potassium carbonate In diethyl ether for 24h; Ambient temperature;100%
With iodine70%
piperazine
110-85-0

piperazine

formaldehyd
50-00-0

formaldehyd

hinokitiol
499-44-5

hinokitiol

1,4-bis(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)piperazine
1211884-65-9

1,4-bis(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)piperazine

Conditions
ConditionsYield
Stage #1: piperazine; formaldehyd; hinokitiol With acetic acid In methanol at 60℃; Mannich reaction;
Stage #2: With sodium hydrogencarbonate In methanol; water
100%
formaldehyd
50-00-0

formaldehyd

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

hinokitiol
499-44-5

hinokitiol

4-(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)-1-piperazinecarboxylic acid ethyl ester
1211884-44-4

4-(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)-1-piperazinecarboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: formaldehyd; 4-ethoxycarbonylpiperazine; hinokitiol With acetic acid In methanol at 60℃; Mannich reaction;
Stage #2: With sodium hydrogencarbonate In methanol; water
99%
formaldehyd
50-00-0

formaldehyd

hinokitiol
499-44-5

hinokitiol

(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-1-yl)methanone
122003-27-4

(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-1-yl)methanone

1-[N-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-ylcarbonyl)]-4-(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)piperazine
1211884-55-7

1-[N-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-ylcarbonyl)]-4-(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)piperazine

Conditions
ConditionsYield
Stage #1: formaldehyd; hinokitiol; (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-1-yl)methanone With acetic acid In methanol at 60℃; Mannich reaction;
Stage #2: With sodium hydrogencarbonate In methanol; water
99%
hinokitiol
499-44-5

hinokitiol

methyl iodide
74-88-4

methyl iodide

4-isopropyltropolone methyl ether
18448-52-7

4-isopropyltropolone methyl ether

Conditions
ConditionsYield
With perhydrodibenzo-18-crown-6; potassium carbonate In acetonitrile for 10h; Heating;96.4%
hinokitiol
499-44-5

hinokitiol

trifluoroborane diethyl ether
109-63-7

trifluoroborane diethyl ether

difluoro(3-isopropyl-7-oxo-1,3,5-cycloheptatrienyloxy)borane
2248-50-2

difluoro(3-isopropyl-7-oxo-1,3,5-cycloheptatrienyloxy)borane

Conditions
ConditionsYield
In not given react. hinokitiol and boron trifluoride etherate; product recrystd. from chloroform-benzene (4:7);96%
hinokitiol
499-44-5

hinokitiol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

4-(1-methylethyl)-2-[[(4-methylphenyl)sulfonyl]oxy]-2,4,6-cycloheptatrien-1-one
69141-46-4

4-(1-methylethyl)-2-[[(4-methylphenyl)sulfonyl]oxy]-2,4,6-cycloheptatrien-1-one

Conditions
ConditionsYield
In pyridine96%
hinokitiol
499-44-5

hinokitiol

OsHCl(CO)(P(p-tolyl)3)3

OsHCl(CO)(P(p-tolyl)3)3

C53H54O3OsP2

C53H54O3OsP2

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In benzene for 2.5h; Reflux; Inert atmosphere;95%
indium chloride

indium chloride

hinokitiol
499-44-5

hinokitiol

trans-{tris(4-iso-propyl-2-hydroxy-2,4,6-cycloheptatrien-1-onato-O,O')-indium(III)}
154727-99-8, 16973-43-6

trans-{tris(4-iso-propyl-2-hydroxy-2,4,6-cycloheptatrien-1-onato-O,O')-indium(III)}

Conditions
ConditionsYield
In ethanol refluxed; 1 h; left to stand for 48 h;; pptd. from H2O; crystd. after 48 h; washed with EtOH/H2O; dried over CaCl2; elem. anal.;;91%
hydridocarbonylchlorotris(triphenylphosphine)osmium(II)
16971-31-6, 36007-23-5

hydridocarbonylchlorotris(triphenylphosphine)osmium(II)

hinokitiol
499-44-5

hinokitiol

C47H42O3OsP2

C47H42O3OsP2

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In benzene for 5.5h; Reflux; Inert atmosphere;91%
morpholine
110-91-8

morpholine

formaldehyd
50-00-0

formaldehyd

hinokitiol
499-44-5

hinokitiol

4-(4-isopropyl-6-hydroxy-7-oxo-1,3,5-cycloheptatrienylmethyl)morpholine

4-(4-isopropyl-6-hydroxy-7-oxo-1,3,5-cycloheptatrienylmethyl)morpholine

Conditions
ConditionsYield
With acetic acid In methanol at 60℃; Mannich reaction;88%
(carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II)
157072-60-1, 61521-25-3, 166941-05-5, 16971-33-8

(carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II)

hinokitiol
499-44-5

hinokitiol

C47H42O3P2Ru

C47H42O3P2Ru

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In benzene for 2.5h; Reflux; Inert atmosphere;88%
Iron(III) nitrate nonahydrate

Iron(III) nitrate nonahydrate

hinokitiol
499-44-5

hinokitiol

tris(4-isopropyltropolonato)iron(III)
31396-80-2

tris(4-isopropyltropolonato)iron(III)

Conditions
ConditionsYield
In methanol; ethanol to soln. of iron salt in MeOH was added to soln. of hinokitiol in MeOH, stirred for 1 h at room temp.; filtered, washed with EtOH, Et2O, dried in vac. for 2 h;87.6%
In ethanol at 20℃; for 2h;86.7%
copper(ll) sulfate pentahydrate

copper(ll) sulfate pentahydrate

hinokitiol
499-44-5

hinokitiol

[Cu(II)(4-isopropyltropolone)2] C20H22CuO4, monoclinic, P21/N
14076-63-2, 685836-60-6

[Cu(II)(4-isopropyltropolone)2] C20H22CuO4, monoclinic, P21/N

Conditions
ConditionsYield
In ethanol; water to soln. of ligand in 1:1 mixt. EtOH and water (20 ml) was added CuSO4, soln. was refluxed for 2 h; soln. was passed through folded filter paper, filtrate was evapd. slowlyat room temp., after few days crystals were grown, ppt. collected, wash ed with H2O, dried in vac.; elem. anal.;76.5%
hinokitiol
499-44-5

hinokitiol

3,4,5-Trimethoxybenzoyl chloride
4521-61-3

3,4,5-Trimethoxybenzoyl chloride

3,4,5-trimethoxy-benzoic acid 3-isopropyl-7-oxo-cyclohepta-1,3,5-trienyl ester

3,4,5-trimethoxy-benzoic acid 3-isopropyl-7-oxo-cyclohepta-1,3,5-trienyl ester

Conditions
ConditionsYield
With pyridine In dichloromethane for 12h; Heating;76%
hinokitiol
499-44-5

hinokitiol

titanium tetrachloride
7550-45-0

titanium tetrachloride

[Ti(hinokitiol)2Cl2]
1106674-51-4

[Ti(hinokitiol)2Cl2]

Conditions
ConditionsYield
In methanol; diethyl ether to soln. of TiCl4 in ether was added soln. of hinokitiol in ether, stirred for 2 h at room temp.; filtered, washed with ether, dried in vac. for 2 h;74.1%
4-methoxybenzaldehyde diethylacetal
2403-58-9

4-methoxybenzaldehyde diethylacetal

hinokitiol
499-44-5

hinokitiol

3-(α-ethoxy-4-methoxybenzyl)-6-isopropyltropolone
92832-11-6

3-(α-ethoxy-4-methoxybenzyl)-6-isopropyltropolone

Conditions
ConditionsYield
In toluene for 20h; Heating;72%
6-hydroxy-2,5,7,8-tetramethyl-N-(2-piperazinoethyl)-2-chromanecarboxamide
313988-88-4

6-hydroxy-2,5,7,8-tetramethyl-N-(2-piperazinoethyl)-2-chromanecarboxamide

formaldehyd
50-00-0

formaldehyd

hinokitiol
499-44-5

hinokitiol

1-[N-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-ylcarbonyl)ethylamino]-4-(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)piperazine
1211884-59-1

1-[N-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-ylcarbonyl)ethylamino]-4-(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)piperazine

Conditions
ConditionsYield
Stage #1: 6-hydroxy-2,5,7,8-tetramethyl-N-(2-piperazinoethyl)-2-chromanecarboxamide; formaldehyd; hinokitiol With acetic acid In methanol at 60℃; Mannich reaction;
Stage #2: With sodium hydrogencarbonate In methanol; water
71%
tris(triphenylphosphine)ruthenium(II) chloride
15529-49-4, 41756-81-4

tris(triphenylphosphine)ruthenium(II) chloride

hinokitiol
499-44-5

hinokitiol

C56H52O4P2Ru

C56H52O4P2Ru

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In ethanol for 1.5h; Inert atmosphere; Reflux;71%
copper(ll) sulfate pentahydrate

copper(ll) sulfate pentahydrate

hinokitiol
499-44-5

hinokitiol

[Cu(II)(4-isopropyltropolone)2]

[Cu(II)(4-isopropyltropolone)2]

Conditions
ConditionsYield
In ethanol; water to soln. of ligand in 1:1 mixt. EtOH and water (30 ml) was added CuSO4, soln. was refluxed for 2 h; soln. was passed through folded filter paper, filtrate was evapd. slowlyat room temp., after few days crystals were grown, ppt. collected, wash ed with H2O, dried in vac.; elem. anal.;70.7%
1-ethoxyisochromane
75802-22-1

1-ethoxyisochromane

hinokitiol
499-44-5

hinokitiol

3-(1-isochromanyl)-6-isopropyltropolone
87864-22-0

3-(1-isochromanyl)-6-isopropyltropolone

Conditions
ConditionsYield
at 150 - 160℃; for 6h;66%
heating;
hinokitiol
499-44-5

hinokitiol

4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

4-methoxy-benzoic acid 3-isopropyl-7-oxo-cyclohepta-1,3,5-trienyl ester

4-methoxy-benzoic acid 3-isopropyl-7-oxo-cyclohepta-1,3,5-trienyl ester

Conditions
ConditionsYield
With pyridine In dichloromethane for 12h; Heating;65%
hinokitiol
499-44-5

hinokitiol

antimony(III) bromide
7789-61-9

antimony(III) bromide

[Sb(III)(hinokitiol)2Br]

[Sb(III)(hinokitiol)2Br]

Conditions
ConditionsYield
In methanol; benzene to soln. of SbBr3 in C6H6 was added soln. of hinokitiol in MeOH, stirredfor 2 h; filtered, evapd. in vac. at 30°C, dissolved in EtOH, filtered, filtrate slow evapd. at room temp., filtered, washed with cold EtOH, driedin vac. for 2 h;62.5%
tin(II) chloride dihdyrate
10025-69-1

tin(II) chloride dihdyrate

hinokitiol
499-44-5

hinokitiol

Sn(hinokitiol)2
58528-20-4

Sn(hinokitiol)2

Conditions
ConditionsYield
In ethanol; water a soln. of hydroxyketone in ethanol was added a stirred soln. of Sn-compound in water under N2, the soln. was stirred for 1.5 h; filtered, ppt. was dried under vac.; elem. anal.;56%
1,1-diethoxy-but-2-ene
10602-34-3

1,1-diethoxy-but-2-ene

hinokitiol
499-44-5

hinokitiol

3-isopropyl-6-(1-ethoxy-2-butenyl)tropolone
92397-04-1

3-isopropyl-6-(1-ethoxy-2-butenyl)tropolone

Conditions
ConditionsYield
at 160℃; for 5h;55%
formaldehyd
50-00-0

formaldehyd

hinokitiol
499-44-5

hinokitiol

1-(3,4-dimethoxybenzoyl)piperazine

1-(3,4-dimethoxybenzoyl)piperazine

7-[4-(3-(3,4-dimethoxybenzoyl)piperazin-1-yl)methyl]-2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one

7-[4-(3-(3,4-dimethoxybenzoyl)piperazin-1-yl)methyl]-2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one

Conditions
ConditionsYield
With acetic acid In methanol at 60℃;55%

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