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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2,4-Dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,4-Dimethyl-5-thiazolecarboxylic acid

Cas:53137-27-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Now we would like to update our product list for you, kindly check the below information: 1. Catalyst series ( such as Noble Metal Catalyst, Phosphorous ligand, etc ) 2. Pharmaceutical Intermediate ( such as diabtes series, Anti

53137-27-2

Cas:53137-27-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 53137-27-2 with competitive price

Cas:53137-27-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

5-Thiazolecarboxylicacid, 2,4-dimethyl-/ LIDE PHARMA- Factory supply / Best price

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:53137-27-2

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2,4-DIMETHYLTHIAZOLE-5-CARBOXYLIC ACID

Cas:53137-27-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5-Thiazolecarboxylicacid, 2,4-dimethyl-

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2,4-Dimethylthiazole-5-carboxylicacid

Cas:53137-27-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2,4-Dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2,4-dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2,4-Dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Greenutra Resource Inc

2,4-Dimethylthiazole-5-carboxylic acidAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

2,4-Dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2,4-Dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

2,4-DiMethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2,4-Dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer Answer: Yes, we are factory founded on 2012.Q2: How to contact with us Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours.Q3:Which kind of payment terms do you

2,4-Dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 2,4-Dimethylthiazole-5-carboxylic acid 5g

Cas:53137-27-2

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high qualityAppearance:white crystalline powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

GERANYL ISOVALERATE

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

2,4-Dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2,4-DiMethyl-1,3-thiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

2,4-Dimethylthiazole-5-carboxylic acid cas 53137-27-2Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

2,4-Dimethylthiazole-5-carboxylic acid cas 53137-27-2

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

2,4-Dimethylthiazole-5-carboxylicacid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2,4-Dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

2,4-dimethylthiazole-5-carboxylic acid 53137-27-2

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shenzhen Foris Technology Co. LTD

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

2,4-dimethylthiazole-5-carboxylic acid 53137-27-2

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2,4-Dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

2,4-Dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

2,4-Dimethylthiazole-5-carboxylic acid

Cas:53137-27-2

Min.Order:0

Negotiable

Type:Other

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

2,4-Dimethyl-1,3-thiazole-5-carboxylicacid

Cas:53137-27-2

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate
7210-77-7

ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate

2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water for 4h; Reflux;90%
With potassium hydroxide
With potassium hydroxide In methanol; water
5-bromo-2,4-dimethyl-1,3-thiazole
28599-52-2

5-bromo-2,4-dimethyl-1,3-thiazole

2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

Conditions
ConditionsYield
With ethanol; phenyllithium Behandeln des Reaktionsgemisches mit CO2;
ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate
7210-77-7

ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate

A

2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

B

2,4-dimethyl-thiazole-5-carboxylic acid amide
66806-33-5

2,4-dimethyl-thiazole-5-carboxylic acid amide

Conditions
ConditionsYield
With ammonia
2,4-dimethyl-thiazole-5-carboxylic acid methyl ester; hydrochloride

2,4-dimethyl-thiazole-5-carboxylic acid methyl ester; hydrochloride

2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide at 20℃; Hydrolysis;
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

tert-butyl alcohol
75-65-0

tert-butyl alcohol

tert-butyl (2,4-dimethylthiazol-5-yl)carbamate

tert-butyl (2,4-dimethylthiazol-5-yl)carbamate

Conditions
ConditionsYield
With triethanolamine; diphenyl phosphoryl azide at 85℃; for 3h; Inert atmosphere;96.5%
With diphenyl phosphoryl azide; triethylamine at 85℃; for 4h;88.54%
1,4-dioxane
123-91-1

1,4-dioxane

2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

1,4-dioxan-2-yl 2,4-dimethylthiazole-5-carboxylate
1597710-80-9

1,4-dioxan-2-yl 2,4-dimethylthiazole-5-carboxylate

Conditions
ConditionsYield
With iron(III)-acetylacetonate; di-tert-butyl peroxide at 120℃; for 24h; Schlenk technique;94%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

iodobenzene
591-50-4

iodobenzene

2,4-dimethyl-5-phenylthiazole
19968-55-9

2,4-dimethyl-5-phenylthiazole

Conditions
ConditionsYield
With silver (II) carbonate; triphenylphosphine; palladium dichloride In N,N-dimethyl acetamide; toluene at 135℃; for 16h; Sealed tube;93%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

potassium 2,4-dimethyl-1,3-thiazole-5-carboxylate
1227469-85-3

potassium 2,4-dimethyl-1,3-thiazole-5-carboxylate

Conditions
ConditionsYield
With potassium tert-butylate In ethanol at 20℃; for 3h; Inert atmosphere;89%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

1-(4-methoxyphenyl)-3-methylpiperazin-2-one hydrochloride

1-(4-methoxyphenyl)-3-methylpiperazin-2-one hydrochloride

C18H21N3O3S

C18H21N3O3S

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;
Stage #2: 1-(4-methoxyphenyl)-3-methylpiperazin-2-one hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h; Cooling with ice;
88%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

6-(2-aminooxazol-4-yl)-3,4-dihydroquinolin-2(1H)-one

6-(2-aminooxazol-4-yl)-3,4-dihydroquinolin-2(1H)-one

2,4-dimethyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)oxazol-2-yl)thiazole-5-carboxamide

2,4-dimethyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)oxazol-2-yl)thiazole-5-carboxamide

Conditions
ConditionsYield
With pyridine; propylphosphonic anhydride In ethyl acetate; acetonitrile at 50℃; for 120h; Sealed tube;87%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

dichloromethane
75-09-2

dichloromethane

C13H14N2O4S2

C13H14N2O4S2

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 130℃; for 5h;84%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

3-Methyl-5-pyridin-2-yl-3H-[1,2,3]-triazole-4-carbaldehyde
1374645-80-3

3-Methyl-5-pyridin-2-yl-3H-[1,2,3]-triazole-4-carbaldehyde

2-[2-hydroxy-2-(3-methyl-5-pyridin-2-yl-3H-[1,2,3]triazol-4-yl)-ethyl]-4-methyl-thiazole-5-carboxylic acid
1374645-81-4

2-[2-hydroxy-2-(3-methyl-5-pyridin-2-yl-3H-[1,2,3]triazol-4-yl)-ethyl]-4-methyl-thiazole-5-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With n-butyllithium In tetrahydrofuran; hexanes at -75℃; for 2h; Inert atmosphere;
Stage #2: 3-Methyl-5-pyridin-2-yl-3H-[1,2,3]-triazole-4-carbaldehyde In tetrahydrofuran; hexanes at -75℃; for 2h;
Stage #3: With citric acid In tetrahydrofuran; hexanes; water
83%
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With n-butyllithium In tetrahydrofuran; hexane at -75℃; for 2h; Inert atmosphere;
Stage #2: 3-Methyl-5-pyridin-2-yl-3H-[1,2,3]-triazole-4-carbaldehyde In tetrahydrofuran; hexane at -75℃; for 2h;
83%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

6-(2-aminothiazol-4-yl)-3,4-dihydroquinazolin-2(1H)-one

6-(2-aminothiazol-4-yl)-3,4-dihydroquinazolin-2(1H)-one

2,4-dimethyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)thiazol-2-yl)thiazole-5-carboxamide

2,4-dimethyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)thiazol-2-yl)thiazole-5-carboxamide

Conditions
ConditionsYield
With pyridine; propylphosphonic anhydride In ethyl acetate; acetonitrile at 50℃; for 120h; Sealed tube;82%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

tetraethylammonium hydroxide
77-98-5

tetraethylammonium hydroxide

tetraethylammonium 2,4-dimethylthiazole-5-carboxylate

tetraethylammonium 2,4-dimethylthiazole-5-carboxylate

Conditions
ConditionsYield
In methanol; water at 20℃;81%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

8-{3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]propoxy}-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine
1032571-04-2

8-{3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]propoxy}-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine

N-(8-{3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]propoxyl}-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-2,4-dimethyl-1,3-thiazole-5-carboxamide
1032568-41-4

N-(8-{3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]propoxyl}-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-2,4-dimethyl-1,3-thiazole-5-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;80%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

8-(2-aminothiazol-4-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

8-(2-aminothiazol-4-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

2,4-dimethyl-N-(4-(4-oxo-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-8-yl)thiazol-2-yl)thiazole-5-carboxamide

2,4-dimethyl-N-(4-(4-oxo-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-8-yl)thiazol-2-yl)thiazole-5-carboxamide

Conditions
ConditionsYield
With pyridine; propylphosphonic anhydride In ethyl acetate; acetonitrile at 50℃; for 120h; Sealed tube;79%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

6-(2'-Amino-5'-Methylthiazol-4'-Yl)-3,4-Dihydrocarbostyril

6-(2'-Amino-5'-Methylthiazol-4'-Yl)-3,4-Dihydrocarbostyril

2,4-dimethyl-N-(5-methyl-4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)thiazole-5-carboxamide

2,4-dimethyl-N-(5-methyl-4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)thiazole-5-carboxamide

Conditions
ConditionsYield
With pyridine; propylphosphonic anhydride In ethyl acetate; acetonitrile at 50℃; for 144h; Sealed tube;78%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

4-methylthiosemicarbazide
6610-29-3

4-methylthiosemicarbazide

5-(2,4-dimethyl-1,3-thiazol-5-yl)-4-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

5-(2,4-dimethyl-1,3-thiazol-5-yl)-4-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid; 4-methylthiosemicarbazide With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;
Stage #2: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate; N,N-dimethyl-formamide at 0 - 20℃; for 2h;
Stage #3: With hydrogenchloride; sodium hydroxide more than 3 stages;
77%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazole-4-carbaldehyde
1374645-74-5

5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazole-4-carbaldehyde

2-{2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-2-hydroxy-ethyl}-4-methyl-thiazole-5-carboxylic acid
1374645-83-6

2-{2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-2-hydroxy-ethyl}-4-methyl-thiazole-5-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With n-butyllithium In tetrahydrofuran; hexanes at -75℃; for 2h; Inert atmosphere;
Stage #2: 5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazole-4-carbaldehyde In tetrahydrofuran; hexanes at -75℃; for 2h;
Stage #3: With citric acid In tetrahydrofuran; hexanes; water
77%
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With n-butyllithium In tetrahydrofuran; hexane at -75℃; for 2h; Inert atmosphere;
Stage #2: 5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazole-4-carbaldehyde In tetrahydrofuran; hexane at -75℃; for 2h;
77%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

1-(4-methoxyphenyl)-3-phenylpiperazin-2-one

1-(4-methoxyphenyl)-3-phenylpiperazin-2-one

4-(2,4-dimethyl-1,3-thiazole-5-carbonyl)-1-(4-methoxyphenyl)-3-phenylpiperazin-2-one

4-(2,4-dimethyl-1,3-thiazole-5-carbonyl)-1-(4-methoxyphenyl)-3-phenylpiperazin-2-one

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1-(4-methoxyphenyl)-3-phenylpiperazin-2-one In N,N-dimethyl-formamide at 20℃; for 3h; Cooling with ice;
76%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

benzylamine
100-46-9

benzylamine

N-benzyl-2,4-dimethylthiazole-5-carboxamide

N-benzyl-2,4-dimethylthiazole-5-carboxamide

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: benzylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
75.6%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

1-Adamantanamine
768-94-5

1-Adamantanamine

N-(adamantan-1-yl)-2,4-dimethylthiazole-5-carboxamide

N-(adamantan-1-yl)-2,4-dimethylthiazole-5-carboxamide

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 1-Adamantanamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
75.2%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

2-(3-aminophenyl)ethan-1-ol
52273-77-5

2-(3-aminophenyl)ethan-1-ol

N-[3-(2-hydroxyethyl)phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide
844904-20-7

N-[3-(2-hydroxyethyl)phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide) for 14h;73%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

6-(2'-Amino-5'-ethylthiazol-4'-yl)-3,4-dihydrocarbostyril

6-(2'-Amino-5'-ethylthiazol-4'-yl)-3,4-dihydrocarbostyril

N-(5-ethyl-4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)-2,4-dimethylthiazole-5-carboxamide

N-(5-ethyl-4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)-2,4-dimethylthiazole-5-carboxamide

Conditions
ConditionsYield
With pyridine; propylphosphonic anhydride In ethyl acetate; acetonitrile at 50℃; for 144h; Sealed tube;73%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

1,2,3,4-tetrahydronaphthalen-1-amine
2217-40-5

1,2,3,4-tetrahydronaphthalen-1-amine

2,4-dimethyl-N-(1,2,3,4-tetrahydronaphthalen-1-yl)thiazole-5-carboxamide

2,4-dimethyl-N-(1,2,3,4-tetrahydronaphthalen-1-yl)thiazole-5-carboxamide

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 1,2,3,4-tetrahydronaphthalen-1-amine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
71.4%
1H-imidazole
288-32-4

1H-imidazole

2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

2-(thien-3-yl)aminoacetonitrile

2-(thien-3-yl)aminoacetonitrile

2-(2,4-dimethylthiazole-5-carboxamido)-2-(3-thienyl)acetonitrile
119778-31-3

2-(2,4-dimethylthiazole-5-carboxamido)-2-(3-thienyl)acetonitrile

Conditions
ConditionsYield
With thionyl chloride In tetrahydrofuran; water70%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

4-iodopyridine
15854-87-2

4-iodopyridine

2,4-dimethyl-5-pyridinylthiazole

2,4-dimethyl-5-pyridinylthiazole

Conditions
ConditionsYield
With silver (II) carbonate; triphenylphosphine; palladium dichloride In N,N-dimethyl acetamide; toluene at 135℃; for 16h; Sealed tube;70%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

Ethyl isocyanoacetate
2999-46-4

Ethyl isocyanoacetate

ethyl 5-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-oxazole-4-carboxylate

ethyl 5-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-oxazole-4-carboxylate

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 2h;
Stage #2: Ethyl isocyanoacetate With lithium hexamethyldisilazane In tetrahydrofuran at 0 - 20℃; for 1h;
70%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

3-butyl-4-chloromethyl-5-methyl-isoxazole
1254962-92-9

3-butyl-4-chloromethyl-5-methyl-isoxazole

2-[2-(3-butyl-5-methyl-isoxazol-4-yl)-ethyl]-4-methyl-thiazole-5-carboxylic acid
1254970-01-8

2-[2-(3-butyl-5-methyl-isoxazol-4-yl)-ethyl]-4-methyl-thiazole-5-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With lithium diisopropyl amide In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: 3-butyl-4-chloromethyl-5-methyl-isoxazole In tetrahydrofuran for 1h;
Stage #3: With hydrogenchloride In tetrahydrofuran; water
68%
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With n-butyllithium In tetrahydrofuran; hexanes at -78℃; Inert atmosphere;
Stage #2: 3-butyl-4-chloromethyl-5-methyl-isoxazole In tetrahydrofuran; hexanes at -75℃;
Stage #3: With citric acid In tetrahydrofuran; hexanes
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

6-(2-aminothiazol-4-yl)chroman-2-one

6-(2-aminothiazol-4-yl)chroman-2-one

2,4-dimethyl-N-(4-(2-oxochroman-6-yl)thiazol-2-yl)thiazole-5-carboxamide

2,4-dimethyl-N-(4-(2-oxochroman-6-yl)thiazol-2-yl)thiazole-5-carboxamide

Conditions
ConditionsYield
With pyridine; propylphosphonic anhydride In ethyl acetate; acetonitrile at 48.5℃; for 120h; Sealed tube;67%
1H-imidazole
288-32-4

1H-imidazole

2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

α-(2-thienyl)aminoacetonitrile
779315-19-4

α-(2-thienyl)aminoacetonitrile

2-(2,4-dimethylthiazole-5-carboxamido)-2-(2-thienyl)acetonitrile
119778-30-2

2-(2,4-dimethylthiazole-5-carboxamido)-2-(2-thienyl)acetonitrile

Conditions
ConditionsYield
With thionyl chloride In tetrahydrofuran; water65%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

(6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)-quinolin-3-yl-amine dihydrochloride

(6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)-quinolin-3-yl-amine dihydrochloride

(2,4-dimethyl-thiazol-5-yl)-[4-(quinolin-3-ylamino)-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl]-methanone
1227460-58-3

(2,4-dimethyl-thiazol-5-yl)-[4-(quinolin-3-ylamino)-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl]-methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In 1-methyl-pyrrolidin-2-one at 20℃; for 0.0833333h;64%
2,4-dimethyl-thiazole-5-carboxylic acid
53137-27-2

2,4-dimethyl-thiazole-5-carboxylic acid

4-chloromethyl-5-methyl-3-phenyl-isoxazole
18718-83-7

4-chloromethyl-5-methyl-3-phenyl-isoxazole

4-methyl-2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid
1254969-88-4

4-methyl-2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With lithium diisopropyl amide In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: 4-chloromethyl-5-methyl-3-phenyl-isoxazole In tetrahydrofuran for 1h;
Stage #3: With hydrogenchloride In tetrahydrofuran; water
60%

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