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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Idarubicin hydrochloride Manufacturer/High quality/Best price/In stock

Cas:57852-57-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name Idarubicin hydrochloride Synonyms (7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione hydrochlor

Idarubicin hydrochloride

Cas:57852-57-0

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1g/foil bag Application:medicine raw material Transportation:by courie

Manufacturer high quality Idarubicin hydrochloride Cas 57852-57-0 with good price

Cas:57852-57-0

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:White or

Idarubicin?hydrochloride

Cas:57852-57-0

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% Idarubicin HCl 57852-57-0 Producer

Cas:57852-57-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Idarubicin hydrochloride

Cas:57852-57-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Idarubicin hydrochloride CAS NO:57852-57-0 Grade:Medical scientific research and export Molecular formula:C26H28ClNO9 Molecular weight:533.9548 Product Quality 12 years of chemical raw materials Mature operation of the industry System

Idarubicin hydrochloride/ CAS:57852-57-0/raw material/ high-quality

Cas:57852-57-0

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Idarubicin hydrochloride

Cas:57852-57-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 57852-57-0 with competitive price

Cas:57852-57-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Idarubicin hydrochloride

Cas:57852-57-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Top Quality Factory Supplier Price Powder Idarubicin Hydrochloride 57852-57-0

Cas:57852-57-0

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Qingdao Beluga Import and Export Co., LTD

Idarubicin hydrochloride CAS:57852-57-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

Idarubicin hydrochloride CAS:57852-57-0

Cas:57852-57-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Idarubicin HCl 57852-57-0

Cas:57852-57-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Idarubicin Hydrochloride

Cas:57852-57-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Idarubicin hydrochloride

Cas:57852-57-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

afine+IDARUBICIN HYDROCHLORIDE

Cas:57852-57-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Idarubicin HCl

Cas:57852-57-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

Idarubicin HCl

Cas:57852-57-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Idarubicin hydrochloride Manufacturers

Cas:57852-57-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

cas:57852-57-0 Idarubicin hydrochlorideAppearance:White powder Storage:Store in cool & dry place Package:according to customers' requirements Application:Medicine Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ec

cas:57852-57-0 Idarubicin hydrochloride

Cas:57852-57-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Idarubicin hydrochloride

Cas:57852-57-0

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Idarubicin hydrochloride

Cas:57852-57-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

57852-57-0 Idarubicin hydrochloride

Cas:57852-57-0

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Idarubicin hydrochloride USP/EP/BP

Cas:57852-57-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

IdarubicinHCl

Cas:57852-57-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Idarubicin hydrochloride

Cas:57852-57-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Synthetic route

idarubicin
58957-92-9

idarubicin

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In chloroform; isopropyl alcohol95%
With hydrogenchloride In methanol; dichloromethane pH=3;4.2 g
With hydrogenchloride In methanol; ethanol; dichloromethane; water at 30 - 40℃; for 0.333333h; pH=Ca. 3; Inert atmosphere;4.2 g
(+)-N-Trifluoroacetyl-4-demethoxydaunorubicin
60660-74-4

(+)-N-Trifluoroacetyl-4-demethoxydaunorubicin

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Stage #1: (+)-N-Trifluoroacetyl-4-demethoxydaunorubicin With water; sodium hydroxide at 20℃; for 1h;
Stage #2: With hydrogenchloride In water pH=8;
80%
With sodium hydroxide In water for 0.5h; Ambient temperature;77%
Stage #1: (+)-N-Trifluoroacetyl-4-demethoxydaunorubicin With sodium hydroxide In water at 30℃; for 0.5h;
Stage #2: With hydrogenchloride In chloroform; water; butan-1-ol pH=3.5;
Stage #1: (+)-N-Trifluoroacetyl-4-demethoxydaunorubicin With sodium hydroxide In water at 30℃; for 0.5h;
Stage #2: With hydrogenchloride In water pH=7;
C34H35NO10

C34H35NO10

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Stage #1: C34H35NO10 With palladium(II) hydroxide In tetrahydrofuran at 40℃; for 4h;
Stage #2: With hydrogenchloride In methanol; diethyl ether pH=3;
77%
C34H33NO11

C34H33NO11

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Stage #1: C34H33NO11 With palladium(II) hydroxide In tetrahydrofuran at 40℃; for 4h;
Stage #2: With hydrogenchloride In methanol; dichloromethane pH=3;
74%
2,3,6-trideoxy-1,4-di-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxopyranose
52583-22-9

2,3,6-trideoxy-1,4-di-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxopyranose

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) Trimethylsilyl triflate, 4A mol. sieves / 1.) CH2Cl2-Et2O (3:1), -40 deg C than -3 - -5 deg C, 1h; 2.) -15 deg C, 2.5 hrs
2: 0.1 mol dm-3 NaOH / CH2Cl2; methanol / 0.5 h / 0 °C
3: 77 percent / 0.1 mol dm-3 NaOH / H2O / 0.5 h / Ambient temperature
View Scheme
(7S,9S)-idarubicinone
60660-75-5

(7S,9S)-idarubicinone

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) Trimethylsilyl triflate, 4A mol. sieves / 1.) CH2Cl2-Et2O (3:1), -40 deg C than -3 - -5 deg C, 1h; 2.) -15 deg C, 2.5 hrs
2: 0.1 mol dm-3 NaOH / CH2Cl2; methanol / 0.5 h / 0 °C
3: 77 percent / 0.1 mol dm-3 NaOH / H2O / 0.5 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: 51 percent / Silver triflate
2: 0.1 mol dm-3 NaOH / CH2Cl2; methanol / 0.5 h / 0 °C
3: 77 percent / 0.1 mol dm-3 NaOH / H2O / 0.5 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
2: 77 percent / 0.1 mol dm-3 NaOH / H2O / 0.5 h / Ambient temperature
View Scheme
1-chloro-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxohexopyranose
63700-25-4

1-chloro-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxohexopyranose

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 51 percent / Silver triflate
2: 0.1 mol dm-3 NaOH / CH2Cl2; methanol / 0.5 h / 0 °C
3: 77 percent / 0.1 mol dm-3 NaOH / H2O / 0.5 h / Ambient temperature
View Scheme
2,3,6-Trideoxy-3-trifluoroacetamido-L-lixo-hexopyranose
51996-45-3, 56354-08-6, 64429-67-0, 71952-66-4, 122350-89-4

2,3,6-Trideoxy-3-trifluoroacetamido-L-lixo-hexopyranose

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 51 percent / diethyl ether
3: 77 percent / 0.1 mol dm-3 NaOH / H2O / 0.5 h / Ambient temperature
View Scheme
(-)-3-N-trifluoroacetyl-1,4-bis(O-trifluoroacetyl)-L-daunosamine
91108-50-8

(-)-3-N-trifluoroacetyl-1,4-bis(O-trifluoroacetyl)-L-daunosamine

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 77 percent / 0.1 mol dm-3 NaOH / H2O / 0.5 h / Ambient temperature
View Scheme
(-)-4'-O-p-Nitrobenzoyl-N-trifluoroacetyl-4-demethoxydaunorubicin
82343-11-1, 84276-23-3, 103665-89-0

(-)-4'-O-p-Nitrobenzoyl-N-trifluoroacetyl-4-demethoxydaunorubicin

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 0.1 mol dm-3 NaOH / CH2Cl2; methanol / 0.5 h / 0 °C
2: 77 percent / 0.1 mol dm-3 NaOH / H2O / 0.5 h / Ambient temperature
View Scheme
daunomycin hydrochloride
23541-50-6

daunomycin hydrochloride

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: dichloromethane / 1.5 h / 0 °C
2.1: potassium iodide; magnesium chloride / tetrahydrofuran / 1.5 h / 40 °C
2.2: pH 2.5 / Cooling with ice
3.1: dmap; N-ethyl-N,N-diisopropylamine / pyridine / 1 h / 0 - 20 °C
4.1: triethylammonium formate; 1,1'-bis(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere
5.1: sodium hydroxide / water / 0.5 h / 30 °C
5.2: pH 7
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate; trifluoromethanesulfonyl azide / dichloromethane; water; methanol
2.1: potassium iodide; magnesium chloride / tetrahydrofuran / 1.5 h / 40 °C
2.2: pH 2.5 / Cooling with ice
3.1: dmap; N-ethyl-N,N-diisopropylamine / pyridine / 1 h / 0 - 20 °C
4.1: triethylammonium formate; 1,1'-bis(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere
5.1: triphenylphosphine / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 20 °C
2.1: bis(1,5-cyclooctadiene)nickel (0); tricyclohexylphosphine; Hexamethyldisiloxane / toluene / 12 h / 80 - 110 °C
3.1: palladium(II) hydroxide / tetrahydrofuran / 4 h / 40 °C
3.2: pH 3
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile / 10 h / 20 °C
2.1: bis(1,5-cyclooctadiene)nickel (0); tricyclohexylphosphine; Hexamethyldisiloxane / toluene / 12 h / 80 - 110 °C
3.1: palladium(II) hydroxide / tetrahydrofuran / 4 h / 40 °C
3.2: pH 3
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 4 h / 20 °C
2.1: bis(1,5-cyclooctadiene)nickel (0); tricyclohexylphosphine; Hexamethyldisiloxane / toluene / 12 h / 80 - 110 °C
3.1: water; sodium hydroxide / 1 h / 20 °C
3.2: pH 8
View Scheme
4-demethyl-3'-trifluoroacetamido-daunorubicine
68594-06-9

4-demethyl-3'-trifluoroacetamido-daunorubicine

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine / pyridine / 1 h / 0 - 20 °C
2.1: triethylammonium formate; 1,1'-bis(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere
3.1: sodium hydroxide / water / 0.5 h / 30 °C
3.2: pH 7
View Scheme
3'-N-trifluoroacetyldaunorubicin
26388-52-3

3'-N-trifluoroacetyldaunorubicin

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium iodide; magnesium chloride / tetrahydrofuran / 1.5 h / 40 °C
1.2: pH 2.5 / Cooling with ice
2.1: dmap; N-ethyl-N,N-diisopropylamine / pyridine / 1 h / 0 - 20 °C
3.1: triethylammonium formate; 1,1'-bis(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere
4.1: sodium hydroxide / water / 0.5 h / 30 °C
4.2: pH 7
View Scheme
Multi-step reaction with 2 steps
1.1: bis(1,5-cyclooctadiene)nickel (0); tricyclohexylphosphine; Hexamethyldisiloxane / toluene / 12 h / 80 - 110 °C
2.1: water; sodium hydroxide / 1 h / 20 °C
2.2: pH 8
View Scheme
7-(3-azido-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)daunorubicinone
874384-80-2

7-(3-azido-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)daunorubicinone

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium iodide; magnesium chloride / tetrahydrofuran / 1.5 h / 40 °C
1.2: pH 2.5 / Cooling with ice
2.1: dmap; N-ethyl-N,N-diisopropylamine / pyridine / 1 h / 0 - 20 °C
3.1: triethylammonium formate; 1,1'-bis(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere
4.1: triphenylphosphine / tetrahydrofuran / 20 °C
View Scheme
4-demethyl-3'-N3-daunorubicine
1403987-61-0

4-demethyl-3'-N3-daunorubicine

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dmap; N-ethyl-N,N-diisopropylamine / pyridine / 1 h / 0 - 20 °C
2: triethylammonium formate; 1,1'-bis(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere
3: triphenylphosphine / tetrahydrofuran / 20 °C
View Scheme
C27H24F3N3O12S
1403872-35-4

C27H24F3N3O12S

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylammonium formate; 1,1'-bis(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere
2: triphenylphosphine / tetrahydrofuran / 20 °C
View Scheme
4-demethoxy-3'-N3-daunorubicin
1403872-37-6

4-demethoxy-3'-N3-daunorubicin

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Stage #1: 4-demethoxy-3'-N3-daunorubicin With triphenylphosphine In tetrahydrofuran at 20℃;
Stage #2: With ammonia In tetrahydrofuran; methanol
C35H35NO12

C35H35NO12

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: bis(1,5-cyclooctadiene)nickel (0); tricyclohexylphosphine; Hexamethyldisiloxane / toluene / 12 h / 80 - 110 °C
2.1: palladium(II) hydroxide / tetrahydrofuran / 4 h / 40 °C
2.2: pH 3
View Scheme
C35H37NO11

C35H37NO11

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: bis(1,5-cyclooctadiene)nickel (0); tricyclohexylphosphine; Hexamethyldisiloxane / toluene / 12 h / 80 - 110 °C
2.1: palladium(II) hydroxide / tetrahydrofuran / 4 h / 40 °C
2.2: pH 3
View Scheme
4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

(8S,10S)-9-acetyl-7-[(3-[(4-fluorobenzoyl)amino]-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione

(8S,10S)-9-acetyl-7-[(3-[(4-fluorobenzoyl)amino]-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 0.25h;96%
ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

(+)-N-Trifluoroacetyl-4-demethoxydaunorubicin
60660-74-4

(+)-N-Trifluoroacetyl-4-demethoxydaunorubicin

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 4h;94%
idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

A

(7S,9S)-idarubicinone
60660-75-5

(7S,9S)-idarubicinone

B

8-Acetyl-6,11-dihydroxy-naphthacene-5,12-dione
84499-12-7

8-Acetyl-6,11-dihydroxy-naphthacene-5,12-dione

Conditions
ConditionsYield
With ammonia In water at 4 - 20℃; for 25 - 149h; pH=6.56 - 6.69; Product distribution / selectivity;
With hydrogenchloride In water at 4 - 20℃; for 27 - 407h; pH=2.18 - 3.91; Product distribution / selectivity;A 0.57%
B 0.01%
With carbon dioxide; ammonium bicarbonate In water pH=5.73 - 6.14; Product distribution / selectivity;A 0.14%
B 0.05%
idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

(7S,9S)-idarubicinone
60660-75-5

(7S,9S)-idarubicinone

Conditions
ConditionsYield
With hydrogenchloride In water at 4℃; for 29 - 364h; pH=3.03; Product distribution / selectivity;0.14%
With ammonium acetate; acetic acid In water pH=5.14 - 6.05; Product distribution / selectivity;0.03%
With acetic acid In water pH=5.82; Product distribution / selectivity;0.14%
sodium formate
141-53-7

sodium formate

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

(+)-14-formyloxy-4-demethoxydaunorubicin hydrochloride
95237-58-4

(+)-14-formyloxy-4-demethoxydaunorubicin hydrochloride

Conditions
ConditionsYield
Yield given. Multistep reaction;
idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

trimethyl orthoformate
149-73-5

trimethyl orthoformate

(7S,9S)-7-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-9-(1,1-dimethoxy-ethyl)-6,9,11-trihydroxy-7,8,9,10-tetrahydro-naphthacene-5,12-dione

(7S,9S)-7-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-9-(1,1-dimethoxy-ethyl)-6,9,11-trihydroxy-7,8,9,10-tetrahydro-naphthacene-5,12-dione

Conditions
ConditionsYield
With camphor-10-sulfonic acid In methanol at 20℃; for 16h; ketalization;
2-bromo<1,1,2,2-2H4>ethanol
81764-55-8

2-bromo<1,1,2,2-2H4>ethanol

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

4-demethoxy-3'-N-(2-hydroxy[2H4]ethyl)daunorubicin

4-demethoxy-3'-N-(2-hydroxy[2H4]ethyl)daunorubicin

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 36℃; for 48h;
idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

4-[18F]fluorobenzoic acid
10011-97-9

4-[18F]fluorobenzoic acid

C33H30(18)FNO10

C33H30(18)FNO10

Conditions
ConditionsYield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In acetonitrile at 110℃; for 0.166667h;
idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

[18F]-4-fluorobenzoic acid chloride
594847-99-1

[18F]-4-fluorobenzoic acid chloride

C33H30(18)FNO10

C33H30(18)FNO10

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.166667h;
idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

4-demethoxy-3'-N-(2-methanesulphonyl[2H4]ethyl)-4'-O-methanesulphonyl-daunorubicin
476675-75-9

4-demethoxy-3'-N-(2-methanesulphonyl[2H4]ethyl)-4'-O-methanesulphonyl-daunorubicin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: DIEA / CH2Cl2 / 48 h / 36 °C
2: pyridine / 2.5 h / 5 °C
View Scheme
idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

(1S)-cis-3-acetyl-1,2,3,4,5,12-hexahydro-5,12-dioxonaphthacene-1,3-diol
76155-93-6

(1S)-cis-3-acetyl-1,2,3,4,5,12-hexahydro-5,12-dioxonaphthacene-1,3-diol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: camphorsulfonic acid / methanol / 16 h / 20 °C
2.1: LiBH4 / methanol; tetrahydrofuran / 1.83 h / cooling
2.2: aq. HBr / tetrahydrofuran; acetone; methanol / 0.5 h / 20 °C
3.1: aq. HCl / 1 h / Heating
View Scheme
idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

4,5,12-trisdeoxydaunorubicin

4,5,12-trisdeoxydaunorubicin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: camphorsulfonic acid / methanol / 16 h / 20 °C
2.1: LiBH4 / methanol; tetrahydrofuran / 1.83 h / cooling
2.2: aq. HBr / tetrahydrofuran; acetone; methanol / 0.5 h / 20 °C
View Scheme
idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

(+)-4-demethoxyadriamycin hydrochloride
64363-63-9, 92691-66-2

(+)-4-demethoxyadriamycin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: NaOH / methanol / 0.17 h / 0 - 5 °C
View Scheme
idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

4-demethoxydoxorubicin
62348-68-9, 64314-52-9, 73804-55-4

4-demethoxydoxorubicin

Conditions
ConditionsYield
With hydrogenchloride; hydrogen bromide; bromine; sodium formate In 1,4-dioxane; methanol; diethyl ether; chloroform; water; Petroleum ether
heptakis-[6-(2-aminoethylsulfanyl)-6-deoxy]-β-cyclodextrin heptahydrochloride

heptakis-[6-(2-aminoethylsulfanyl)-6-deoxy]-β-cyclodextrin heptahydrochloride

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

C26H27NO9*C56H105N7O28S7*8ClH

C26H27NO9*C56H105N7O28S7*8ClH

Conditions
ConditionsYield
at 25℃; pH=7.4; aq. phosphate buffer;
heptakis-[6-deoxy-6-(2-sulfanylethanesulfonic acid)]-β-cyclodextrin

heptakis-[6-deoxy-6-(2-sulfanylethanesulfonic acid)]-β-cyclodextrin

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

C26H27NO9*C56H91O49S14(7-)*ClH*7Na(1+)

C26H27NO9*C56H91O49S14(7-)*ClH*7Na(1+)

Conditions
ConditionsYield
In water at 25℃;
C63H91S7O42(7-)*7Na(1+)

C63H91S7O42(7-)*7Na(1+)

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

C26H27NO9*C63H91O42S7(7-)*ClH*7Na(1+)

C26H27NO9*C63H91O42S7(7-)*ClH*7Na(1+)

Conditions
ConditionsYield
In water at 25℃;
C56H98O35S7
147720-65-8

C56H98O35S7

idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

C26H27NO9*C56H98O35S7*ClH

C26H27NO9*C56H98O35S7*ClH

Conditions
ConditionsYield
In water at 25℃;
idarubicin hydrochloride
57852-57-0

idarubicin hydrochloride

6A,6B,6C,6D,6E,6F,6G-hepta(sodium 2-thioglycolate)-6A,6B,6C,6D,6E,6F,6G-heptadeoxy-β-cyclodextrin

6A,6B,6C,6D,6E,6F,6G-hepta(sodium 2-thioglycolate)-6A,6B,6C,6D,6E,6F,6G-heptadeoxy-β-cyclodextrin

C26H27NO9*C56H77O42S7(7-)*ClH*7Na(1+)

C26H27NO9*C56H77O42S7(7-)*ClH*7Na(1+)

Conditions
ConditionsYield
In water at 25℃;

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