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inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
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Azelastine cas 58581-89-8Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
*stable and better quality products*efficient and meticulous servicesAppearance:Powder Storage:Store in dry, cool and ventilated place Package:1kg/tin 5kg/tin 25kg/carton Application:Pharmaceutical raw materials, making injection powder oral agent Tr
4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone
B
azelastine
Conditions | Yield |
---|---|
With sodium hydroxide at 70℃; for 1h; Yield given; |
2‐(4-chlorophenylacetyl)benzoic acid
azelastine
Conditions | Yield |
---|---|
With hydrogenchloride; potassium hydroxide 1.) reflux, 3 h, 2.) methanol, reflux, 2 h; Yield given. Multistep reaction; |
4-chlorophenylacetic Acid
azelastine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: CH3COONa / 3 h / 245 - 250 °C 2: aq. NaOH / 2 h / Heating 3: 1.) 23percent aq. HCl, 2.) KOH / 1.) reflux, 3 h, 2.) methanol, reflux, 2 h View Scheme | |
Multi-step reaction with 4 steps 1: CH3COONa / 3 h / 245 - 250 °C 2: aq. NaOH / 2 h / Heating 3: 90 percent / hydrazine sulfate, aq. NaOH / 2 h / Heating 4: aq. NaOH / 1 h / 70 °C View Scheme |
1-methyl-1,2,3,5,6,7-hexahydroazepin-4-one
azelastine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2.) NaBH4 / 1.) CH3OH, room temp. 2: 1.) 23percent aq. HCl, 2.) KOH / 1.) reflux, 3 h, 2.) methanol, reflux, 2 h View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium hydroxide / water / 1 h / 25 - 35 °C 1.2: 2 h / 0 - 10 °C 2.1: tetrahydrofuran / 1 h / 0 - 10 °C / Reflux 3.1: hydrogenchloride / 2 h / 20 °C / Reflux 3.2: 2 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium hydroxide / water / 1 h / 25 - 35 °C 1.2: 2 h / 0 - 10 °C 2.1: tetrahydrofuran / 1 h / 0 - 10 °C / Reflux 3.1: hydrogenchloride / 2 h / 20 °C / Reflux 3.2: 2 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium hydroxide / water / 1 h / 25 - 35 °C 1.2: 2 h / 0 - 10 °C 2.1: acetonitrile / 1 h / 0 - 10 °C / Reflux 3.1: hydrogenchloride / 2 h / 20 °C / Reflux 3.2: 2 h / Reflux View Scheme |
phthalic anhydride
azelastine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: CH3COONa / 3 h / 245 - 250 °C 2: aq. NaOH / 2 h / Heating 3: 1.) 23percent aq. HCl, 2.) KOH / 1.) reflux, 3 h, 2.) methanol, reflux, 2 h View Scheme | |
Multi-step reaction with 4 steps 1: CH3COONa / 3 h / 245 - 250 °C 2: aq. NaOH / 2 h / Heating 3: 90 percent / hydrazine sulfate, aq. NaOH / 2 h / Heating 4: aq. NaOH / 1 h / 70 °C View Scheme |
(Z)-3-(4-chlorophenyl)methylidenephthalide
azelastine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aq. NaOH / 2 h / Heating 2: 1.) 23percent aq. HCl, 2.) KOH / 1.) reflux, 3 h, 2.) methanol, reflux, 2 h View Scheme | |
Multi-step reaction with 3 steps 1: aq. NaOH / 2 h / Heating 2: 90 percent / hydrazine sulfate, aq. NaOH / 2 h / Heating 3: aq. NaOH / 1 h / 70 °C View Scheme |
2‐(4-chlorophenylacetyl)benzoic acid
azelastine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / hydrazine sulfate, aq. NaOH / 2 h / Heating 2: aq. NaOH / 1 h / 70 °C View Scheme |
2‐(4-chlorophenylacetyl)benzoic acid
azelastine
Conditions | Yield |
---|---|
Stage #1: 1H-azepine, 4-hydrazinohexahydro-1-methyl, dihydrochloride; 2‐(4-chlorophenylacetyl)benzoic acid With sodium hydroxide In methanol; water for 4h; Heating / reflux; Stage #2: With hydrogenchloride In methanol; 2,8-dimethylnonan-5-one; water |
azelastine hydrochloride
azelastine
Conditions | Yield |
---|---|
With sodium hydroxide In water pH=10; Inert atmosphere; |
Conditions | Yield |
---|---|
Stage #1: C14H23N3O(2+)*C4H2O4(2-) With hydrogenchloride at 20℃; for 2h; Reflux; Stage #2: 2‐(4-chlorophenylacetyl)benzoic acid for 2h; Reflux; | 8.1 g |
Conditions | Yield |
---|---|
Stage #1: C14H23N3O(2+)*C4H2O4(2-) With hydrogenchloride at 20℃; for 2h; Reflux; Stage #2: 2‐(4-chlorophenylacetyl)benzoic acid for 2h; Reflux; | 7.5 g |
azelastine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 1 h / 0 - 10 °C / Reflux 2.1: hydrogenchloride / 2 h / 20 °C / Reflux 2.2: 2 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 1 h / 0 - 10 °C / Reflux 2.1: hydrogenchloride / 2 h / 20 °C / Reflux 2.2: 2 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: acetonitrile / 1 h / 0 - 10 °C / Reflux 2.1: hydrogenchloride / 2 h / 20 °C / Reflux 2.2: 2 h / Reflux View Scheme |
Conditions | Yield |
---|---|
Stage #1: C14H23N3O(2+)*C4H4O4(2-) With hydrogenchloride at 20℃; for 2h; Reflux; Stage #2: 2‐(4-chlorophenylacetyl)benzoic acid for 2h; Reflux; | 8 g |
benzoic acid hydrazide
azelastine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium hydroxide / water / 1 h / 25 - 35 °C 1.2: 2 h / 0 - 10 °C 2.1: tetrahydrofuran / 1 h / 0 - 10 °C / Reflux 3.1: hydrogenchloride / 2 h / 20 °C / Reflux 3.2: 2 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium hydroxide / water / 1 h / 25 - 35 °C 1.2: 2 h / 0 - 10 °C 2.1: tetrahydrofuran / 1 h / 0 - 10 °C / Reflux 3.1: hydrogenchloride / 2 h / 20 °C / Reflux 3.2: 2 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium hydroxide / water / 1 h / 25 - 35 °C 1.2: 2 h / 0 - 10 °C 2.1: acetonitrile / 1 h / 0 - 10 °C / Reflux 3.1: hydrogenchloride / 2 h / 20 °C / Reflux 3.2: 2 h / Reflux View Scheme |
Conditions | Yield |
---|---|
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 72h; Inert atmosphere; | 91% |
azelastine
azelastine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In toluene Reflux; | 87% |
3-methoxyphenylboronic acid
azelastine
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; nickel(II) chloride hexahydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol; N,N-dimethyl acetamide at 80℃; for 21h; Reagent/catalyst; Solvent; Inert atmosphere; Glovebox; | 51% |
phenylmagnesium bromide
azelastine
2-(1-benzylazepan-4-yl)-4-(4-chlorobenzyl)phthalazin-1(2H)-one
Conditions | Yield |
---|---|
Stage #1: azelastine With 1,4-diaza-bicyclo[2.2.2]octane; tri(4-tolyl)aminium hexafluorophosphate In acetonitrile at -5℃; Inert atmosphere; Stage #2: phenylmagnesium bromide In tetrahydrofuran; acetonitrile at 0℃; Inert atmosphere; regioselective reaction; | 25% |
Conditions | Yield |
---|---|
With pentamethylcyclopentadienyl(benzene)cobalt(III) hexafluorophosphate; potassium carbonate; silver carbonate In 2-methyltetrahydrofuran at 100℃; for 16h; Inert atmosphere; Sealed tube; | 25% |
azelastine
Conditions | Yield |
---|---|
With water In ethanol Heating / reflux; |
Conditions | Yield |
---|---|
With mixed selector chiral stationary phase prepared with co-immobilized human serum albumin and cellulase on a poly(glycidylmethacrylate-co-ethylene glycol dimethacrylate) monolith In aq. phosphate buffer; isopropyl alcohol at 20℃; pH=7; Resolution of racemate; |
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