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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-Amino-2-hydroxy-4-phenylbutyric acid

Cas:59554-14-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(αS,βR)-β-Amino-α-hydroxybenzenebutanoic acid

Cas:59554-14-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--59554-14-2--3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established s

TIANFUCHEM--59554-14-2--3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID factory price

Cas:59554-14-2

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 59554-14-2 with competitive price

Cas:59554-14-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid

Cas:59554-14-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-Amino-2-hydroxy-4-phenylbutyric acid

Cas:59554-14-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid

Cas:59554-14-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/(2S,3R)-AHPA

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid Cas no.59554-14-2 98%

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Benzenebutanoic acid, b-amino-a-hydroxy-, (aS,bR)-

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

(2S,3R)-3-AMino-2-hydroxy-4-phenylbutyric acid

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

3-Amino-2-Hydroxy-4-Phenylbutyric Acid

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white to light yellow crystal powder Storage:Room temperature with sealed well Package:according to the clients requirement Appl

(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

AHPAAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

AHPA

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:250mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po

3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Other

inquiry

AstaTech ( Chengdu) BioPharmaceutical Corp.

Quality assurance, stable process and affordable priceAppearance:detailed see specifications Storage:enquiry Package:according to the clients requirement Application:Pharmaceutical intermediates Transportation:Normal Port:chengdu

(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid

Cas:59554-14-2

Min.Order:0

Negotiable

Type:Other

inquiry

Changzhou Extraordinary Pharmatech co.,LTD

Changzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa

3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID

Cas:59554-14-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Xi Ze Biological Technology Co., Ltd

1 Company Introduction NanJing XiZe Biotechnology is a leading manufacturer and supplier of chemicals in China. We develop, produce and distribute high quality pharmaceuticals, impurities, intermediates, special pharmaceutical and intermediates.

(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid

Cas:59554-14-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Watson International Ltd

Watson International Ltd' has a very strong R&D and technical capacity supported by FCAD's platform. The subsidiaries under FCAD Group have accumulated much know-how of different fine chemical branches. For example, Apnoke Scientific L

AHPA

Cas:59554-14-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

suzhou BetterBioChem Co., Ltd.

Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID

Cas:59554-14-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(2S,3R)-3-Amino-2-hydroxy-4-phenyl-butyric acid isopropyl ester
130115-05-8

(2S,3R)-3-Amino-2-hydroxy-4-phenyl-butyric acid isopropyl ester

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
With hydrogenchloride; ion exchange resin (H+) 1.) 4 h, 100 deg C;85%
(2S,3R)-2-hydroxy-4-phenyl-3-(tosylamino)butanoic acid
180922-44-5

(2S,3R)-2-hydroxy-4-phenyl-3-(tosylamino)butanoic acid

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
With Na-naphthalide In 1,2-dimethoxyethane at -78℃; for 0.5h;82%
(2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenyl-butanoic acid
59969-65-2

(2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenyl-butanoic acid

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
With hydrogen; palladium
methyl (4R,5S)-2-oxo-4-phenylmethyl-1,3-oxazolidine-5-carboxylate
95832-38-5

methyl (4R,5S)-2-oxo-4-phenylmethyl-1,3-oxazolidine-5-carboxylate

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
With lithium hydroxide In methanol; water
methyl (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoate
114886-83-8

methyl (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoate

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
With hydrogenchloride
(2S,3R)-2-O-benzyl-4-phenyl-3-[(9-phenyl-9-fluorenyl)-amino]-phenylbutanoic acid
577978-91-7

(2S,3R)-2-O-benzyl-4-phenyl-3-[(9-phenyl-9-fluorenyl)-amino]-phenylbutanoic acid

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol at 70℃; for 12h;
(2S,3R)-3-azido-2-hydroxy-4-phenylbutanoic acid
121445-52-1

(2S,3R)-3-azido-2-hydroxy-4-phenylbutanoic acid

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
With sodium tetrahydroborate; copper(II) nitrate In water at 0℃; for 0.5h;
(4S,5R)-4,5-dihydro-2-phenyl-4-carboethoxy-5-benzyl-1,3-oxazole
869103-47-9

(4S,5R)-4,5-dihydro-2-phenyl-4-carboethoxy-5-benzyl-1,3-oxazole

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water for 8h; Heating;
ethyl (2R,3S)-4-phenyl-2,3-oxiranebutanoate
869103-46-8

ethyl (2R,3S)-4-phenyl-2,3-oxiranebutanoate

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 78 percent / BF3*Et2O / 0 - 20 °C
2: hydrochloric acid / H2O; ethanol / 8 h / Heating
View Scheme
ethyl 3-oxo-4-phenylbutyrate
718-08-1

ethyl 3-oxo-4-phenylbutyrate

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / sulfuryl chloride / CHCl3 / 20 °C
2: 82 percent / Escherichia coli BL21(DE3)(pIK4) overexpressing reductase; glucose; air / KPi buffer; XAD-4 resin / 24 h / 30 °C / pH 5.6
3: 99 percent / potassium carbonate / H2O; dimethylformamide / 5 h / 20 °C
4: 78 percent / BF3*Et2O / 0 - 20 °C
5: hydrochloric acid / H2O; ethanol / 8 h / Heating
View Scheme
ethyl 2-chloro-3-oxo-4-phenylbutyrate
444613-61-0

ethyl 2-chloro-3-oxo-4-phenylbutyrate

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 82 percent / Escherichia coli BL21(DE3)(pIK4) overexpressing reductase; glucose; air / KPi buffer; XAD-4 resin / 24 h / 30 °C / pH 5.6
2: 99 percent / potassium carbonate / H2O; dimethylformamide / 5 h / 20 °C
3: 78 percent / BF3*Et2O / 0 - 20 °C
4: hydrochloric acid / H2O; ethanol / 8 h / Heating
View Scheme
ethyl (2R,3S)-2-chloro-3-hydroxy-4-phenylbutyrate
832110-38-0

ethyl (2R,3S)-2-chloro-3-hydroxy-4-phenylbutyrate

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 99 percent / potassium carbonate / H2O; dimethylformamide / 5 h / 20 °C
2: 78 percent / BF3*Et2O / 0 - 20 °C
3: hydrochloric acid / H2O; ethanol / 8 h / Heating
View Scheme
(Z)-4-phenylbut-2-en-1-ol
22910-59-4

(Z)-4-phenylbut-2-en-1-ol

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: periodic acid; RuCl3
2: NaN3 / Cu(NO3)2 / H2O / 1.5 h / 65 °C
3: NaBH4 / Cu(NO3)2 / H2O / 0.5 h / 0 °C
View Scheme
(2R,3S)-2-Hydroxymethyl-3-phenylmethyloxirane
161170-91-8

(2R,3S)-2-Hydroxymethyl-3-phenylmethyloxirane

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: periodic acid; RuCl3
2: NaN3 / Cu(NO3)2 / H2O / 1.5 h / 65 °C
3: NaBH4 / Cu(NO3)2 / H2O / 0.5 h / 0 °C
View Scheme
(2S,3S)-3-Benzyl-oxirane-2-carboxylic acid
608520-03-2

(2S,3S)-3-Benzyl-oxirane-2-carboxylic acid

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaN3 / Cu(NO3)2 / H2O / 1.5 h / 65 °C
2: NaBH4 / Cu(NO3)2 / H2O / 0.5 h / 0 °C
View Scheme
methyl (2S,3R)-2-methoxy-4-phenyl-3-<(R)-1-phenylethylamino>butanoate
246522-99-6

methyl (2S,3R)-2-methoxy-4-phenyl-3-<(R)-1-phenylethylamino>butanoate

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 81 percent / BBr3 / CH2Cl2 / 2 h / -78 °C
2: 79 percent / H2 / Pd/C / methanol / 15 h / Ambient temperature
3: 2 N aq. HCl
View Scheme
methyl (2S,3R)-2-hydroxy-4-phenyl-3-<(R)-1-phenylethylamino>butanoate
246523-03-5

methyl (2S,3R)-2-hydroxy-4-phenyl-3-<(R)-1-phenylethylamino>butanoate

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 79 percent / H2 / Pd/C / methanol / 15 h / Ambient temperature
2: 2 N aq. HCl
View Scheme
ethyl (2S,3R)-2-hydroxy-4-phenyl-3-(tosylamino)butanoate
180922-42-3

ethyl (2S,3R)-2-hydroxy-4-phenyl-3-(tosylamino)butanoate

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / K2CO3 / methanol; H2O / 24 h / Ambient temperature
2: 82 percent / Na-naphthalide / 1,2-dimethoxy-ethane / 0.5 h / -78 °C
View Scheme
(4R,5S)-5-benzyl-4-(hydroxymethyl)-1,3-oxazolidin-2-one
95832-37-4

(4R,5S)-5-benzyl-4-(hydroxymethyl)-1,3-oxazolidin-2-one

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 2N LiOH / methanol; H2O
View Scheme
N-<(benzyloxy)carbonyl>-(2R)-amino-1-phenylbut-3-ene
95832-30-7

N-<(benzyloxy)carbonyl>-(2R)-amino-1-phenylbut-3-ene

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 95 percent / KH / dimethylformamide; benzene
2: 80 percent / I2
3: 1.) AgOAc, 2.) 1N NaOH / 1.) DMF, AcOH, 2.)MeOH, H2O
4: 82 percent / Na / NH3
6: 2N LiOH / methanol; H2O
View Scheme
(4R,5S)-3,4-Dibenzyl-5-hydroxymethyl-oxazolidin-2-one
95891-28-4

(4R,5S)-3,4-Dibenzyl-5-hydroxymethyl-oxazolidin-2-one

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 82 percent / Na / NH3
3: 2N LiOH / methanol; H2O
View Scheme
Z-D-phenylalanine ethyl ester
95832-31-8

Z-D-phenylalanine ethyl ester

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) DIBAH, 2.) KH / 1.) toluene, 2.) toluene and THF
2: 95 percent / KH / dimethylformamide; benzene
3: 80 percent / I2
4: 1.) AgOAc, 2.) 1N NaOH / 1.) DMF, AcOH, 2.)MeOH, H2O
5: 82 percent / Na / NH3
7: 2N LiOH / methanol; H2O
View Scheme
Benzyl-((R)-1-benzyl-allyl)-carbamic acid benzyl ester
95832-34-1

Benzyl-((R)-1-benzyl-allyl)-carbamic acid benzyl ester

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 80 percent / I2
2: 1.) AgOAc, 2.) 1N NaOH / 1.) DMF, AcOH, 2.)MeOH, H2O
3: 82 percent / Na / NH3
5: 2N LiOH / methanol; H2O
View Scheme
(4R,5S)-3,4-Dibenzyl-5-iodomethyl-oxazolidin-2-one
95832-35-2

(4R,5S)-3,4-Dibenzyl-5-iodomethyl-oxazolidin-2-one

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) AgOAc, 2.) 1N NaOH / 1.) DMF, AcOH, 2.)MeOH, H2O
2: 82 percent / Na / NH3
4: 2N LiOH / methanol; H2O
View Scheme
(S)-Methyl mandelate
21210-43-5

(S)-Methyl mandelate

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 93 percent / ImH / dimethylformamide / Ambient temperature
2: 80 percent / DIBAL / diethyl ether; hexane / 0.33 h / -78 °C
3: 100 percent / anhyd. MgSO4 / toluene / 0.83 h / 0 °C
4: NEt3 / CH2Cl2 / Ambient temperature
5: 70 percent / HCl
6: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C
7: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature
8: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C
View Scheme
(2S)-2-(tert-butyldimethylsilyloxy)-2-phenylacetaldehyde
133187-22-1

(2S)-2-(tert-butyldimethylsilyloxy)-2-phenylacetaldehyde

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 100 percent / anhyd. MgSO4 / toluene / 0.83 h / 0 °C
2: NEt3 / CH2Cl2 / Ambient temperature
3: 70 percent / HCl
4: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C
5: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature
6: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C
View Scheme
Methyl (S)-(+)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate
133187-21-0

Methyl (S)-(+)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 80 percent / DIBAL / diethyl ether; hexane / 0.33 h / -78 °C
2: 100 percent / anhyd. MgSO4 / toluene / 0.83 h / 0 °C
3: NEt3 / CH2Cl2 / Ambient temperature
4: 70 percent / HCl
5: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C
6: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature
7: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C
View Scheme
(2S,3R,4S)-3-Amino-2-benzyloxy-4-hydroxy-4-phenyl-butyric acid isopropyl ester
130115-10-5, 139630-60-7

(2S,3R,4S)-3-Amino-2-benzyloxy-4-hydroxy-4-phenyl-butyric acid isopropyl ester

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C
2: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature
3: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C
View Scheme
[Bis-(4-methoxy-phenyl)-methyl]-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine
139580-07-7

[Bis-(4-methoxy-phenyl)-methyl]-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: NEt3 / CH2Cl2 / Ambient temperature
2: 70 percent / HCl
3: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C
4: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature
5: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C
View Scheme
methanol
67-56-1

methanol

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

(2S,3R)-3-Amino-2-hydroxy-4-phenyl-butyric acid methyl ester; hydrochloride

(2S,3R)-3-Amino-2-hydroxy-4-phenyl-butyric acid methyl ester; hydrochloride

Conditions
ConditionsYield
With chloro-trimethyl-silane Heating;100%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

(2S,3R)-3-[(tert-butoxycarbonyl) amino]-2-hydroxy-4-phenyl-butanoic acid
62023-65-8

(2S,3R)-3-[(tert-butoxycarbonyl) amino]-2-hydroxy-4-phenyl-butanoic acid

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; water at 0 - 20℃; for 1h;100%
With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 24h;99%
With triethylamine In tetrahydrofuran; water at 10 - 25℃; Cooling with ice;81%
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Fmoc AHPA

Fmoc AHPA

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; water at 0 - 20℃; for 1h;100%
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

benzyl chloroformate
501-53-1

benzyl chloroformate

(2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenyl-butanoic acid
59969-65-2

(2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenyl-butanoic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran at 20℃; for 6h; Cooling with ice;64%
With sodium hydroxide In diethyl ether; water Yield given;
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Carbonic acid tert-butyl ester 4,5-dimethyl-pyrimidin-2-yl ester

Carbonic acid tert-butyl ester 4,5-dimethyl-pyrimidin-2-yl ester

(2S,3R)-3-[(tert-butoxycarbonyl) amino]-2-hydroxy-4-phenyl-butanoic acid
62023-65-8

(2S,3R)-3-[(tert-butoxycarbonyl) amino]-2-hydroxy-4-phenyl-butanoic acid

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

(2S,3R)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-2-hydroxy-4-phenyl-butyric acid

(2S,3R)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-2-hydroxy-4-phenyl-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / Me3SiCl / Heating
2: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et3N / CH2Cl2 / 18 h / 23 °C
3: aq. NaOH / methanol / 2 h / 25 °C
View Scheme
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

(2S,3R)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-2-hydroxy-4-phenyl-butyric acid methyl ester

(2S,3R)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-2-hydroxy-4-phenyl-butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / Me3SiCl / Heating
2: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et3N / CH2Cl2 / 18 h / 23 °C
View Scheme
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

5-Chloro-1H-indole-2-carboxylic acid ((1R,2S)-1-benzyl-2-dimethylcarbamoyl-2-hydroxy-ethyl)-amide

5-Chloro-1H-indole-2-carboxylic acid ((1R,2S)-1-benzyl-2-dimethylcarbamoyl-2-hydroxy-ethyl)-amide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 100 percent / Me3SiCl / Heating
2: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et3N / CH2Cl2 / 18 h / 23 °C
3: aq. NaOH / methanol / 2 h / 25 °C
4: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et3N / dimethylformamide / 18 h / 23 °C
View Scheme
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate
60016-66-2

benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1N NaOH / diethyl ether; H2O
2: 95 percent / DCC, HOBt, Et3N / CH2Cl2; tetrahydrofuran
View Scheme
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
59554-14-2

(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

bestatin
58970-76-6

bestatin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1N NaOH / diethyl ether; H2O
2: 95 percent / DCC, HOBt, Et3N / CH2Cl2; tetrahydrofuran
3: H2 / Pd black / H2O; methanol
View Scheme

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