Luhan Pharmachem Co., Ltd. owns strong elite professional quality sales force, has the customer base from the US, Europe, Japan, Southeast Asia, Korea, Hong Kong, Taiwan and other countries and regions, the company operates in accordance with the mod
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:616201-80-0
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:616201-80-0
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:616201-80-0
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
Name: Lorcaserin A CAS:616201-80-0 MF: C11H14ClN Appearance:Light yellow to yellow oily Storage:Preserve in well-closed, light-resistant and airtight containers. Package:25kg Application: Pharmaceutical Intermediate Transportation:By sea or by air
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:616201-80-0
Min.Order:10 Gram
Negotiable
Type:Other
inquiryLorcaserinA CAS:616201-80-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:616201-80-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Cas:616201-80-0
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:616201-80-0
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryLorcaserin AAppearance:Colorless transparent liquid Storage:Protected from light, stored hermetically and in a dry place Package:according to customers' requirements Application:Pharmaceutical Transportation:By air(EMS or EUB or FedEx or TNT ect...)
Product name: 8-Chloro-1-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine CAS No.:616201-80-0 Molecule Formula:C11H14ClN Molecule Weight:195.69 Purity: 99.0% Package: 25kg/drum Description:Light yellow to yellow powder Manufacture Standards:Enterpri
Cas:616201-80-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I
We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou
Cas:616201-80-0
Min.Order:0
Negotiable
Type:Manufacturers
inquiryhigh purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier
Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is an impo
Cas:616201-80-0
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li
Cas:616201-80-0
Min.Order:0
Negotiable
Type:Trading Company
inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepineAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express
Cas:616201-80-0
Min.Order:0
Negotiable
Type:Other
inquiry1-((2-(4-chlorophenyl)ethyl)amino)-2-chloropropane hydrochloride
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With aluminum (III) chloride In 1,2-dichloro-benzene at 120 - 125℃; Inert atmosphere; | 99% |
With aluminum (III) chloride at 120 - 125℃; for 3h; Inert atmosphere; Large scale; | 97% |
With aluminum (III) chloride In 1,2-dichloro-benzene at 135 - 140℃; | 96.1% |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; for 4h; Solvent; Temperature; Reagent/catalyst; Friedel-Crafts Alkylation; Inert atmosphere; Large scale; | 92.3% |
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; Friedel-Crafts Alkylation; | 84.5% |
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; | 84.5% |
With zinc(II) chloride at 125℃; for 6.41667h; Reagent/catalyst; Friedel-Crafts Alkylation; | 230 mg |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; Friedel-Crafts Alkylation; | 83.9% |
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; | 83.9% |
N-(4-chlorophenylethyl)propyl-2-ene-1-amine
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With aluminum (III) chloride In 1,2-dichloro-benzene at 90℃; Friedel-Crafts Alkylation; | 82.1% |
With aluminum (III) chloride at 125℃; for 6.41667h; Friedel-Crafts Alkylation; | 230 mg |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With aluminum (III) chloride In chlorobenzene at 110℃; Solvent; Temperature; | 81.6% |
Multi-step reaction with 2 steps 1: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale 2: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / ethyl acetate / 20 °C 2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme | |
Multi-step reaction with 2 steps 1: dichloromethane / 25 °C 2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / water; ethyl acetate / 20 °C 2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme |
8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With borane-THF at 20℃; for 10h; | 70% |
With borane In diethyl ether | |
With sodium tetrahydroborate; chloro-trimethyl-silane In 1,2-dichloro-ethane at 70℃; for 20h; Solvent; Temperature; Cooling with ice; | 0.89 g |
N-(4-chlorophenylethyl)-2-chloropropanamide
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: AlCl3 / 150 - 200 °C 2: BH3 / diethyl ether View Scheme | |
Multi-step reaction with 2 steps 1: aluminum (III) chloride / 8 h / 150 °C 2: chloro-trimethyl-silane; sodium tetrahydroborate / 1,2-dichloro-ethane / 20 h / 70 °C / Cooling with ice View Scheme |
4-chlorophenylethylamine
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine / CH2Cl2 2: AlCl3 / 150 - 200 °C 3: BH3 / diethyl ether View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / tetrahydrofuran / 18 h / 20 °C 2: zinc(II) chloride / 6.42 h / 125 °C View Scheme | |
Multi-step reaction with 4 steps 1: dmap / dichloromethane / 0 - 20 °C / Large scale 2: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 5 h / 80 °C / Large scale 3: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale 4: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale View Scheme |
(1R,S)-N-trifluoroacetyl-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 60℃; for 3.5h; | 35 mg |
With sodium hydroxide In methanol | |
With sodium hydroxide In methanol; water at 60℃; for 3.5h; |
1-((2-(4-chlorophenyl)ethyl)amino)-2-chloropropane hydrochloride
1,2-dichloro-benzene
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Stage #1: 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride; 1,2-dichloro-benzene With aluminum (III) chloride at 126℃; for 16h; Friedel Crafts; Industry scale; Inert atmosphere; Stage #2: With sodium hydroxide In cyclohexane; water pH=12; Product distribution / selectivity; Industry scale; |
1-(2-bromoethyl)-4-chlorobenzene
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Reflux 2: zinc(II) chloride / 6.42 h / 125 °C View Scheme |
2-(4-Chlorophenyl)ethanol
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine; dmap / dichloromethane / 4 h 2.1: dichloromethane / Reflux 2.2: Reflux 3.1: zinc(II) chloride / 6.42 h / 125 °C View Scheme |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With aluminum (III) chloride at 150℃; |
2-(3-chlorophenyl) propan-1-amine
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Inert atmosphere 2: pyridine / dichloromethane / 2.5 h / 20 °C 3: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere 4: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr 5: hydrogen bromide; phenol; propionic acid / 6 h / Reflux View Scheme |
2-(3-chlorophenyl)-N-(2,2-dimethoxyethyl)propan-1-amine
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: pyridine / dichloromethane / 2.5 h / 20 °C 2: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere 3: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr 4: hydrogen bromide; phenol; propionic acid / 6 h / Reflux View Scheme |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere 2: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr 3: hydrogen bromide; phenol; propionic acid / 6 h / Reflux View Scheme |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr 2: hydrogen bromide; phenol; propionic acid / 6 h / Reflux View Scheme |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With hydrogen bromide; propionic acid; phenol for 6h; Reflux; |
Allyl chloroformate
C
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Stage #1: (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride; Allyl chloroformate With triethylamine In dichloromethane at 0 - 20℃; Stage #2: With potassium tert-butylate In dimethyl sulfoxide at 100℃; | A n/a B n/a C 28 %Spectr. |
(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With potassium tert-butylate In dimethyl sulfoxide at 90℃; Reagent/catalyst; Temperature; |
B
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C 2: potassium tert-butylate / dimethyl sulfoxide / 100 °C View Scheme |
B
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / acetone; water / 0 - 20 °C 2: sodium hydroxide / dimethyl sulfoxide / 100 °C View Scheme |
B
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With potassium tert-butylate In dimethyl sulfoxide at 100℃; Reagent/catalyst; | A n/a B 12 %Spectr. |
B
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With sodium hydroxide In dimethyl sulfoxide at 100℃; | A n/a B 25 %Spectr. |
1-[2-(tert-butoxycarbonylamino)ethyl]4-chlorobenzene
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 5 h / 80 °C / Large scale 2: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale 3: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 80 °C 2: dichloromethane / 25 °C 3: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 80 °C 2: hydrogenchloride / ethyl acetate / 20 °C 3: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; aluminum (III) chloride; chloro-trimethyl-silane / tetrahydrofuran / 24 h / 70 °C / Inert atmosphere 2: aluminum (III) chloride / 1,2-dichloro-benzene / 16 h / 130 °C View Scheme |
4-chlorophenylacetic Acid
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: boric acid / toluene / 24 h / 40 - 135 °C 2: dimethylsulfide borane complex / tetrahydrofuran / 2.75 h / 8 - 45 °C 3: aluminum (III) chloride / 1,2-dichloro-benzene / 8 h / 5 - 125 °C View Scheme |
(+/-)-Lorcaserin
Lorcaserin hydrochloride
Conditions | Yield |
---|---|
Stage #1: (+/-)-Lorcaserin With L-Tartaric acid In ethanol; water at 80℃; Stage #2: With potassium carbonate In water pH=12; Stage #3: With hydrogenchloride In water; ethyl acetate at 5 - 10℃; for 1h; | 80% |
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: hydrogenchloride / ethyl acetate; water / pH 5 / Industry scale View Scheme | |
Multi-step reaction with 2 steps 1.1: water; tert-butyl alcohol / 10 h / 20 °C 2.1: sodium hydroxide / water / 0.17 h / 20 °C 2.2: 0.08 h / 20 °C View Scheme |
L-Tartaric acid
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
In water; tert-butyl alcohol at 20 - 78℃; for 4h; | 48% |
In water; acetone at 58℃; for 2h; Concentration; | 37.1% |
In acetone at 50℃; for 3h; | 33.2% |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
With L-Tartaric acid In water; acetone at 45 - 50℃; for 0.5h; | 36.6% |
L-Tartaric acid
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
In water; acetone at 50℃; for 3h; Large scale; | 33.2% |
Stage #1: L-Tartaric acid; (+/-)-Lorcaserin In water; acetone at 50℃; for 3h; Stage #2: In water; acetone at 0 - 5℃; for 5h; Reflux; | 32.8% |
In water; acetone at 45 - 50℃; for 3h; | 17.9% |
In water; acetone at 47 - 52℃; for 0.0833333 - 0.25h; L-(+)-tartaric acid salt of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; Resolution of racemate; | n/a |
L-Tartaric acid
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
In water; acetone at 0 - 52℃; for 2.08 - 3.25h; | 27.1% |
Conditions | Yield |
---|---|
In water; acetone at 0 - 55℃; | 24.1% |
1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Stage #1: 1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane; (+/-)-Lorcaserin With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 70 - 75℃; for 5h; Stage #2: With isopropyl alcohol hydrogen chloride at 0 - 5℃; for 1h; | 18.3% |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Stage #1: (+/-)-Lorcaserin With L-Tartaric acid In water; acetone at 45 - 50℃; for 3h; Stage #2: With ammonium hydroxide In water; ethyl acetate for 0.5h; pH=> 10; Further stages; | 17.9% |
(+/-)-Lorcaserin
A
(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine
Conditions | Yield |
---|---|
chiral HPLC; |
L-Tartaric acid
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
In water; acetone at 47 - 52℃; for 2 - 3h; | n/a |
In water; acetone at 45℃; for 0.333333h; Temperature; Large scale; | 158 kg |
L-Tartaric acid
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
In water; acetone at 45℃; for 0.333333h; Product distribution / selectivity; Industry scale; |
(+/-)-Lorcaserin
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine adipate salt
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: acetone / 0.08 h / 62 °C View Scheme |
(+/-)-Lorcaserin
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine malonate salt
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: Isopropyl acetate View Scheme |
(+/-)-Lorcaserin
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine glycolate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: 60 °C / Cooling View Scheme |
(+/-)-Lorcaserin
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine bisulfate salt
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: sulfuric acid View Scheme |
(+/-)-Lorcaserin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: sulfuric acid View Scheme |
(+/-)-Lorcaserin
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: hydrogen bromide / water / 38 °C / Inert atmosphere View Scheme |
(+/-)-Lorcaserin
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: 20 - 60 °C View Scheme |
(+/-)-Lorcaserin
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine nitrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: nitric acid / water View Scheme |
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