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Luhan Pharmachem Co., Ltd

Luhan Pharmachem Co., Ltd. owns strong elite professional quality sales force, has the customer base from the US, Europe, Japan, Southeast Asia, Korea, Hong Kong, Taiwan and other countries and regions, the company operates in accordance with the mod

LorcaserinA

Cas:616201-80-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

7-Chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Cas:616201-80-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C11H14ClN LorcaserinA 616201-80-0

Cas:616201-80-0

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 616201-80-0 with competitive price

Cas:616201-80-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

LorcaserinA

Cas:616201-80-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name: Lorcaserin A CAS:616201-80-0 MF: C11H14ClN Appearance:Light yellow to yellow oily Storage:Preserve in well-closed, light-resistant and airtight containers. Package:25kg Application: Pharmaceutical Intermediate Transportation:By sea or by air

Lorcaserin A

Cas:616201-80-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 616201-80-0 LorcaserinA with best price

Cas:616201-80-0

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Qingdao Beluga Import and Export Co., LTD

LorcaserinA CAS:616201-80-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

LorcaserinA CAS:616201-80-0

Cas:616201-80-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

LorcaserinA

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Cas:616201-80-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Lorcaserin A

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products LorcaserinA

Cas:616201-80-0

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Lorcaserin A

Cas:616201-80-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Lorcaserin AAppearance:Colorless transparent liquid Storage:Protected from light, stored hermetically and in a dry place Package:according to customers' requirements Application:Pharmaceutical Transportation:By air(EMS or EUB or FedEx or TNT ect...)

Lorcaserin A

Cas:616201-80-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Siwei Development Group Ltd.

Product name: 8-Chloro-1-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine CAS No.:616201-80-0 Molecule Formula:C11H14ClN Molecule Weight:195.69 Purity: 99.0% Package: 25kg/drum Description:Light yellow to yellow powder Manufacture Standards:Enterpri

Best Quality 8-Chloro-1-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine with good supplier

Cas:616201-80-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Lorcaserin A

Cas:616201-80-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

LorcaserinA

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

LorcaserinA

Cas:616201-80-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Lorcaserin A

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Lorcaserin A

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

1H-3-Benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-Methyl-

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

LorcaserinA

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is an impo

7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine supplier in China

Cas:616201-80-0

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

LorcaserinA

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

LorcaserinA

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Koning Pharmchem Co., Ltd.

KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li

8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

LorcaserinA

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

LorcaserinA CAS No.616201-80-0

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

best seller Application:API

LorcaserinA

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepineAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Cas:616201-80-0

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

1-((2-(4-chlorophenyl)ethyl)amino)-2-chloropropane hydrochloride
953789-37-2

1-((2-(4-chlorophenyl)ethyl)amino)-2-chloropropane hydrochloride

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
With aluminum (III) chloride In 1,2-dichloro-benzene at 120 - 125℃; Inert atmosphere;99%
With aluminum (III) chloride at 120 - 125℃; for 3h; Inert atmosphere; Large scale;97%
With aluminum (III) chloride In 1,2-dichloro-benzene at 135 - 140℃;96.1%
N-(4-chlorophenylethyl)propyl-2-ene-1-amine hydrochloride

N-(4-chlorophenylethyl)propyl-2-ene-1-amine hydrochloride

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; for 4h; Solvent; Temperature; Reagent/catalyst; Friedel-Crafts Alkylation; Inert atmosphere; Large scale;92.3%
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; Friedel-Crafts Alkylation;84.5%
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃;84.5%
With zinc(II) chloride at 125℃; for 6.41667h; Reagent/catalyst; Friedel-Crafts Alkylation;230 mg
N-(4-chlorophenylethyl)propyl-2-ene-1-amine trifluoroacetate

N-(4-chlorophenylethyl)propyl-2-ene-1-amine trifluoroacetate

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; Friedel-Crafts Alkylation;83.9%
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃;83.9%
N-(4-chlorophenylethyl)propyl-2-ene-1-amine
1247548-14-6

N-(4-chlorophenylethyl)propyl-2-ene-1-amine

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
With aluminum (III) chloride In 1,2-dichloro-benzene at 90℃; Friedel-Crafts Alkylation;82.1%
With aluminum (III) chloride at 125℃; for 6.41667h; Friedel-Crafts Alkylation;230 mg
N-allyl-N-(4-chlorophenethyl)carbamic acid tert-butyl ester

N-allyl-N-(4-chlorophenethyl)carbamic acid tert-butyl ester

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
With aluminum (III) chloride In chlorobenzene at 110℃; Solvent; Temperature;81.6%
Multi-step reaction with 2 steps
1: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale
2: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride / ethyl acetate / 20 °C
2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane / 25 °C
2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride / water; ethyl acetate / 20 °C
2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C
View Scheme
8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one
824430-77-5

8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
With borane-THF at 20℃; for 10h;70%
With borane In diethyl ether
With sodium tetrahydroborate; chloro-trimethyl-silane In 1,2-dichloro-ethane at 70℃; for 20h; Solvent; Temperature; Cooling with ice;0.89 g
N-(4-chlorophenylethyl)-2-chloropropanamide
34164-14-2

N-(4-chlorophenylethyl)-2-chloropropanamide

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: AlCl3 / 150 - 200 °C
2: BH3 / diethyl ether
View Scheme
Multi-step reaction with 2 steps
1: aluminum (III) chloride / 8 h / 150 °C
2: chloro-trimethyl-silane; sodium tetrahydroborate / 1,2-dichloro-ethane / 20 h / 70 °C / Cooling with ice
View Scheme
4-chlorophenylethylamine
156-41-2

4-chlorophenylethylamine

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine / CH2Cl2
2: AlCl3 / 150 - 200 °C
3: BH3 / diethyl ether
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / tetrahydrofuran / 18 h / 20 °C
2: zinc(II) chloride / 6.42 h / 125 °C
View Scheme
Multi-step reaction with 4 steps
1: dmap / dichloromethane / 0 - 20 °C / Large scale
2: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 5 h / 80 °C / Large scale
3: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale
4: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale
View Scheme
(1R,S)-N-trifluoroacetyl-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine
616202-51-8

(1R,S)-N-trifluoroacetyl-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
With sodium hydroxide In methanol at 60℃; for 3.5h;35 mg
With sodium hydroxide In methanol
With sodium hydroxide In methanol; water at 60℃; for 3.5h;
1-((2-(4-chlorophenyl)ethyl)amino)-2-chloropropane hydrochloride
953789-37-2

1-((2-(4-chlorophenyl)ethyl)amino)-2-chloropropane hydrochloride

1,2-dichloro-benzene
95-50-1

1,2-dichloro-benzene

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Stage #1: 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride; 1,2-dichloro-benzene With aluminum (III) chloride at 126℃; for 16h; Friedel Crafts; Industry scale; Inert atmosphere;
Stage #2: With sodium hydroxide In cyclohexane; water pH=12; Product distribution / selectivity; Industry scale;
1-(2-bromoethyl)-4-chlorobenzene
6529-53-9

1-(2-bromoethyl)-4-chlorobenzene

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Reflux
2: zinc(II) chloride / 6.42 h / 125 °C
View Scheme
2-(4-Chlorophenyl)ethanol
1875-88-3

2-(4-Chlorophenyl)ethanol

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine; dmap / dichloromethane / 4 h
2.1: dichloromethane / Reflux
2.2: Reflux
3.1: zinc(II) chloride / 6.42 h / 125 °C
View Scheme
N-(2-chloroethyl)-2-(3-chlorophenyl ) propan-1-amine

N-(2-chloroethyl)-2-(3-chlorophenyl ) propan-1-amine

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
With aluminum (III) chloride at 150℃;
2-(3-chlorophenyl) propan-1-amine
1082555-06-3

2-(3-chlorophenyl) propan-1-amine

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Inert atmosphere
2: pyridine / dichloromethane / 2.5 h / 20 °C
3: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
4: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr
5: hydrogen bromide; phenol; propionic acid / 6 h / Reflux
View Scheme
2-(3-chlorophenyl)-N-(2,2-dimethoxyethyl)propan-1-amine
1616729-45-3

2-(3-chlorophenyl)-N-(2,2-dimethoxyethyl)propan-1-amine

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine / dichloromethane / 2.5 h / 20 °C
2: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
3: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr
4: hydrogen bromide; phenol; propionic acid / 6 h / Reflux
View Scheme
N-(2-(3-chlorophenyl)propyl)-N-(2,2-dimethoxyethyl)-4-methylbenzenesulfonamide

N-(2-(3-chlorophenyl)propyl)-N-(2,2-dimethoxyethyl)-4-methylbenzenesulfonamide

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
2: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr
3: hydrogen bromide; phenol; propionic acid / 6 h / Reflux
View Scheme
8-chloro-1-methyl-3-tosyl-2,3-dihydro-1H-benzo[d]azepine

8-chloro-1-methyl-3-tosyl-2,3-dihydro-1H-benzo[d]azepine

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr
2: hydrogen bromide; phenol; propionic acid / 6 h / Reflux
View Scheme
8-chloro-1-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

8-chloro-1-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
With hydrogen bromide; propionic acid; phenol for 6h; Reflux;
(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

Allyl chloroformate
2937-50-0

Allyl chloroformate

A

allyl (S)-8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-carboxylate

allyl (S)-8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-carboxylate

B

allyl (R)-8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-carboxylate

allyl (R)-8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-carboxylate

C

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Stage #1: (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride; Allyl chloroformate With triethylamine In dichloromethane at 0 - 20℃;
Stage #2: With potassium tert-butylate In dimethyl sulfoxide at 100℃;
A n/a
B n/a
C 28 %Spectr.
(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine
616202-81-4

(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
With potassium tert-butylate In dimethyl sulfoxide at 90℃; Reagent/catalyst; Temperature;
(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

A

1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

B

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0 - 20 °C
2: potassium tert-butylate / dimethyl sulfoxide / 100 °C
View Scheme
(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

A

1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-yl)-2-phenylethanone

1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-yl)-2-phenylethanone

B

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / acetone; water / 0 - 20 °C
2: sodium hydroxide / dimethyl sulfoxide / 100 °C
View Scheme
(S)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

(S)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

A

1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

B

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
With potassium tert-butylate In dimethyl sulfoxide at 100℃; Reagent/catalyst;A n/a
B 12 %Spectr.
(S)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-yl)-2-phenylethanone

(S)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-yl)-2-phenylethanone

A

1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-yl)-2-phenylethanone

1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-yl)-2-phenylethanone

B

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
With sodium hydroxide In dimethyl sulfoxide at 100℃;A n/a
B 25 %Spectr.
1-[2-(tert-butoxycarbonylamino)ethyl]4-chlorobenzene
167886-56-8

1-[2-(tert-butoxycarbonylamino)ethyl]4-chlorobenzene

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 5 h / 80 °C / Large scale
2: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale
3: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 80 °C
2: dichloromethane / 25 °C
3: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 80 °C
2: hydrogenchloride / ethyl acetate / 20 °C
3: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C
View Scheme
4-chloro-N-(2-chloro-1-oxopropyl)benzeneacetamide

4-chloro-N-(2-chloro-1-oxopropyl)benzeneacetamide

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate; aluminum (III) chloride; chloro-trimethyl-silane / tetrahydrofuran / 24 h / 70 °C / Inert atmosphere
2: aluminum (III) chloride / 1,2-dichloro-benzene / 16 h / 130 °C
View Scheme
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: boric acid / toluene / 24 h / 40 - 135 °C
2: dimethylsulfide borane complex / tetrahydrofuran / 2.75 h / 8 - 45 °C
3: aluminum (III) chloride / 1,2-dichloro-benzene / 8 h / 5 - 125 °C
View Scheme
(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Stage #1: (+/-)-Lorcaserin With L-Tartaric acid In ethanol; water at 80℃;
Stage #2: With potassium carbonate In water pH=12;
Stage #3: With hydrogenchloride In water; ethyl acetate at 5 - 10℃; for 1h;
80%
Multi-step reaction with 3 steps
1: water; acetone / 0.33 h / 45 °C / Industry scale
2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale
3: hydrogenchloride / ethyl acetate; water / pH 5 / Industry scale
View Scheme
Multi-step reaction with 2 steps
1.1: water; tert-butyl alcohol / 10 h / 20 °C
2.1: sodium hydroxide / water / 0.17 h / 20 °C
2.2: 0.08 h / 20 °C
View Scheme
L-Tartaric acid
87-69-4

L-Tartaric acid

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine L-(+)-tartrate

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine L-(+)-tartrate

Conditions
ConditionsYield
In water; tert-butyl alcohol at 20 - 78℃; for 4h;48%
In water; acetone at 58℃; for 2h; Concentration;37.1%
In acetone at 50℃; for 3h;33.2%
(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

bis((R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) L-(+)-tartarate

bis((R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) L-(+)-tartarate

Conditions
ConditionsYield
With L-Tartaric acid In water; acetone at 45 - 50℃; for 0.5h;36.6%
L-Tartaric acid
87-69-4

L-Tartaric acid

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

bis((R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) L-(+)-tartarate

bis((R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) L-(+)-tartarate

Conditions
ConditionsYield
In water; acetone at 50℃; for 3h; Large scale;33.2%
Stage #1: L-Tartaric acid; (+/-)-Lorcaserin In water; acetone at 50℃; for 3h;
Stage #2: In water; acetone at 0 - 5℃; for 5h; Reflux;
32.8%
In water; acetone at 45 - 50℃; for 3h;17.9%
In water; acetone at 47 - 52℃; for 0.0833333 - 0.25h; L-(+)-tartaric acid salt of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; Resolution of racemate;n/a
L-Tartaric acid
87-69-4

L-Tartaric acid

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine L-hemitartrate

8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine L-hemitartrate

Conditions
ConditionsYield
In water; acetone at 0 - 52℃; for 2.08 - 3.25h;27.1%
L-Tartaric acid
87-69-4

L-Tartaric acid

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

2C11H14ClN*C4H6O6

2C11H14ClN*C4H6O6

Conditions
ConditionsYield
In water; acetone at 0 - 55℃;24.1%
1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane
847063-13-2

1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

2-(8-chloro-1-methyl-4,5-dihydro-1H-benzazepin-3(2H)-yl)-N-(4-chlorophenethyl)propan-1-amine hydrochloride

2-(8-chloro-1-methyl-4,5-dihydro-1H-benzazepin-3(2H)-yl)-N-(4-chlorophenethyl)propan-1-amine hydrochloride

Conditions
ConditionsYield
Stage #1: 1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane; (+/-)-Lorcaserin With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 70 - 75℃; for 5h;
Stage #2: With isopropyl alcohol hydrogen chloride at 0 - 5℃; for 1h;
18.3%
(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

Conditions
ConditionsYield
Stage #1: (+/-)-Lorcaserin With L-Tartaric acid In water; acetone at 45 - 50℃; for 3h;
Stage #2: With ammonium hydroxide In water; ethyl acetate for 0.5h; pH=> 10; Further stages;
17.9%
(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

A

(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine
616202-81-4

(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine

B

lorcaserin

lorcaserin

Conditions
ConditionsYield
chiral HPLC;
L-Tartaric acid
87-69-4

L-Tartaric acid

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemitartrate

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemitartrate

Conditions
ConditionsYield
In water; acetone at 47 - 52℃; for 2 - 3h;n/a
In water; acetone at 45℃; for 0.333333h; Temperature; Large scale;158 kg
L-Tartaric acid
87-69-4

L-Tartaric acid

(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemitartrate

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemitartrate

Conditions
ConditionsYield
In water; acetone at 45℃; for 0.333333h; Product distribution / selectivity; Industry scale;
(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine adipate salt
1361475-96-8

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine adipate salt

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; acetone / 0.33 h / 45 °C / Industry scale
2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale
3: acetone / 0.08 h / 62 °C
View Scheme
(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine malonate salt
1361475-98-0

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine malonate salt

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; acetone / 0.33 h / 45 °C / Industry scale
2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale
3: Isopropyl acetate
View Scheme
(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine glycolate
1361476-04-1

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine glycolate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; acetone / 0.33 h / 45 °C / Industry scale
2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale
3: 60 °C / Cooling
View Scheme
(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine bisulfate salt
1361475-79-7

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine bisulfate salt

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; acetone / 0.33 h / 45 °C / Industry scale
2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale
3: sulfuric acid
View Scheme
(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemisulfate

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemisulfate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; acetone / 0.33 h / 45 °C / Industry scale
2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale
3: sulfuric acid
View Scheme
(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
1361476-15-4

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; acetone / 0.33 h / 45 °C / Industry scale
2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale
3: hydrogen bromide / water / 38 °C / Inert atmosphere
View Scheme
(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine mesylate
1361475-85-5

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; acetone / 0.33 h / 45 °C / Industry scale
2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale
3: 20 - 60 °C
View Scheme
(+/-)-Lorcaserin
616201-80-0

(+/-)-Lorcaserin

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine nitrate
1361475-90-2

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine nitrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; acetone / 0.33 h / 45 °C / Industry scale
2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale
3: nitric acid / water
View Scheme

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