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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Lorcaserin hydrochloride

Cas:846589-98-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Lorcaserin hydrochloride

Cas:846589-98-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Luhan Pharmachem Co., Ltd

Luhan Pharmachem Co., Ltd. owns strong elite professional quality sales force, has the customer base from the US, Europe, Japan, Southeast Asia, Korea, Hong Kong, Taiwan and other countries and regions, the company operates in accordance with the mod

(R)Lorcaserin hydrochloride

Cas:846589-98-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

Runhui Chem co., lted is a leading domestic pharmaceutical, biopharmaceutical, and health care products r & d outsourcing services company. as an innovation-driven and customer-focused company, run biotech provides a broad and integrated portfo

Lorcaserin hydrochloride CAS NO.846589-98-8

Cas:846589-98-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Lorcaserin Hcl supplier in China

Cas:846589-98-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

ProductName: (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDESynonyms:(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE;LORCASERINHCL;Lorc… Founded in 2014, as a professional international pha

Lorcaserin hydrochloride

Cas:846589-98-8

Min.Order:1 Kilogram

FOB Price: $2000.0

Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Lorcaserin hydrochloride CAS No.846589-98-8

Cas:846589-98-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:medicine raw material Transportatio

Manufacturer high quality Lorcaserin hydrochloride Cas 846589-98-8 with good price

Cas:846589-98-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable

LORCASERIN HYDROCHLORIDE

Cas:846589-98-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE

Cas:846589-98-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Lorcaserin Hcl

Cas:846589-98-8

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Chemwill Asia Co., Ltd.

CHemwill -- Lorcaserin hydrochloride

Cas:846589-98-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Lorcaserin hydrochloride

Cas:846589-98-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Lorcaseri Hydrochloride Raw Powder Weight Loss CAS 846589-98-8 Lorcaseri HCl

Cas:846589-98-8

Min.Order:1 Gram

FOB Price: $2.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C11H15Cl2N (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE 846589-98-8

Cas:846589-98-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 846589-98-8 with competitive price

Cas:846589-98-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

sacubitril/valsartan Lorcaserin hydrochloride

Cas:846589-98-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

1H-3-Benzazepine,8-chloro-2,3,4,5-tetrahydro-1-methyl-, hydrochloride (1:1), (1R)-

Cas:846589-98-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name: (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine hydrochloride CAS:846589-98-8 MF: C11H14ClN·ClH Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:API Transportation:B

(1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine hydrochloride

Cas:846589-98-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-3-Benzazepine,8-chloro-2,3,4,5-tetrahydro-1-methyl-, hydrochloride (1:1), (1R)- 846589-98-8

Cas:846589-98-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Factory Supply Lorcaserin Hydrochloride powder for Loss Weight

Cas:846589-98-8

Min.Order:1000 Gram

FOB Price: $278.0

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE

Cas:846589-98-8

Min.Order:1 Kilogram

FOB Price: $86.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-M/ETHYL-,HYDROCHLORIDE846589-98-8

Cas:846589-98-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Lorcaserin hydrochloride supplier in China CAS NO.846589-98-8

Cas:846589-98-8

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Factory Supply Weight Loss Lorcaserin HCL with best price

Cas:846589-98-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE CAS: 846589-98-8 Specification tests specifications results assay 98% 98% appearance

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-3-Benzazepine,8-chloro-2,3,4,5-tetrahydro-1-methyl-, hydrochloride (1:1), (1R)-

Cas:846589-98-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ShangHai Soyoung Biotechnology Inc

Appearance:White or almost white crystalline powder Storage:3 years if properly stored Package:25 kgs/ fiber drum or according to customer's demand Application:Lorcaserin hydrochloride as an addition to a reduced-calorie diet and exercise, for chron

Hot sales Lorcaserin hydrochloride 846589-98-8

Cas:846589-98-8

Min.Order:1 Kilogram

FOB Price: $1190.0

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Top Quality Safe Fast Shipping Free Customs Lorcaserin hydrochloride CAS 846589-98-8

Cas:846589-98-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine L-(+)-tartrate

8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine L-(+)-tartrate

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Stage #1: 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine L-(+)-tartrate With sodium hydroxide In dichloromethane; water at 10 - 30℃; for 1h;
Stage #2: With hydrogenchloride In ethyl methyl ether at 0 - 10℃; pH=1.5 - 2.5;
98.6%
Multi-step reaction with 2 steps
1.1: sodium hydroxide / water; dichloromethane; tert-butyl alcohol
1.2: 90 - 100 °C / Inert atmosphere
1.3: 10 h / 20 °C
2.1: sodium hydroxide / water / 0.17 h / 20 °C
2.2: 0.08 h / 20 °C
View Scheme
lorcaserin

lorcaserin

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 0 - 5℃; Solvent; Concentration;98%
With hydrogenchloride In water; ethyl acetate pH=<= 5; pH-value; Large scale;98%
With hydrogenchloride In dichloromethane; water at 20℃; for 0.166667h;97%
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemitartrate

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemitartrate

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemitartrate With potassium carbonate In water; ethyl acetate at 15℃; Large scale;
Stage #2: With hydrogenchloride In water; ethyl acetate pH=<= 5; Temperature; Large scale;
98%
Stage #1: (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemitartrate With potassium carbonate In water; ethyl acetate at 20 - 25℃; for 0.5 - 0.666667h;
Stage #2: With hydrogenchloride In water; ethyl acetate at 0 - 5℃;
89.9%
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine L-(+)-tartrate

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine L-(+)-tartrate

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine L-(+)-tartrate With potassium carbonate In water; ethyl acetate at 20℃; for 1h;
Stage #2: With hydrogenchloride In water; ethyl acetate at 0 - 8℃; for 2h; Concentration;
90.5%
Stage #1: (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine L-(+)-tartrate With potassium carbonate In dichloromethane; water at 20℃; for 1h;
Stage #2: With hydrogenchloride In dichloromethane; water for 4h; Solvent; Reagent/catalyst; Cooling with ice;
35.3%
Stage #1: (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine L-(+)-tartrate With sodium hydroxide In water at 20℃; for 0.166667h;
Stage #2: With hydrogenchloride In diethyl ether; dichloromethane at 20℃; for 0.0833333h;
3.88 g
bis((R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) L-(+)-tartarate

bis((R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) L-(+)-tartarate

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Stage #1: bis((R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) L-(+)-tartarate With potassium carbonate In water; ethyl acetate at 20 - 25℃; for 0.5 - 0.666667h;
Stage #2: With hydrogenchloride In water; ethyl acetate at 0 - 5℃; for 3.5 - 4h; (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine;
89.9%
Stage #1: bis((R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) L-(+)-tartarate With sodium hydroxide In dichloromethane; water at 25℃; for 0.5h; pH=10;
Stage #2: With hydrogenchloride In ethyl acetate at 0℃; for 2.5h; pH=2;
2.25 g
Stage #1: bis((R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) L-(+)-tartarate With potassium carbonate In water at 10 - 25℃; for 0.333333h;
Stage #2: With hydrogenchloride In water; ethyl acetate at 0 - 5℃; Temperature;
21.4 g
8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine L-hemitartrate

8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine L-hemitartrate

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Stage #1: 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine L-hemitartrate With potassium carbonate In water; ethyl acetate at 20 - 25℃; for 50.6667h;
Stage #2: With hydrogenchloride In ethyl acetate at 0 - 5℃; for 3.5 - 4h;
89.9%
N-allyl-N-(4-chlorophenethyl)carbamic acid tert-butyl ester

N-allyl-N-(4-chlorophenethyl)carbamic acid tert-butyl ester

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale
2: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale
3: acetone; water / 3 h / 50 °C / Large scale
4: potassium carbonate / water
5: hydrogenchloride / ethyl acetate; ethanol / 20 °C / pH 2
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogenchloride / ethyl acetate / 20 °C
2.1: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C
3.1: acetone; water / 3 h / 50 °C
3.2: 5 h / 0 - 5 °C / Reflux
4.1: sodium hydroxide / dichloromethane; water / 0.5 h / 25 °C / pH 10
4.2: 2.5 h / 0 °C / pH 2
View Scheme
Multi-step reaction with 4 steps
1.1: dichloromethane / 25 °C
2.1: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C
3.1: acetone; water / 3 h / 50 °C
3.2: 5 h / 0 - 5 °C / Reflux
4.1: sodium hydroxide / dichloromethane; water / 0.5 h / 25 °C / pH 10
4.2: 2.5 h / 0 °C / pH 2
View Scheme
Multi-step reaction with 4 steps
1: aluminum (III) chloride / chlorobenzene / 110 °C
2: acetone / 3 h / 50 °C
3: potassium carbonate / water / pH 8-9
4: hydrogenchloride / ethanol; ethyl acetate / 1 h / 20 °C / pH 1-2
View Scheme
N-(4-chlorophenylethyl)propyl-2-ene-1-amine trifluoroacetate

N-(4-chlorophenylethyl)propyl-2-ene-1-amine trifluoroacetate

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C
2.1: acetone; water / 3 h / 50 °C
2.2: 5 h / 0 - 5 °C / Reflux
3.1: sodium hydroxide / dichloromethane; water / 0.5 h / 25 °C / pH 10
3.2: 2.5 h / 0 °C / pH 2
View Scheme
C13H15ClF3NO

C13H15ClF3NO

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide / methanol / 3 h / 60 °C
2.1: aluminum (III) chloride / 1,2-dichloro-benzene / 90 °C
3.1: acetone; water / 3 h / 50 °C
3.2: 5 h / 0 - 5 °C / Reflux
4.1: sodium hydroxide / dichloromethane; water / 0.5 h / 25 °C / pH 10
4.2: 2.5 h / 0 °C / pH 2
View Scheme
N-(4-chlorophenylethyl)propyl-2-ene-1-amine
1247548-14-6

N-(4-chlorophenylethyl)propyl-2-ene-1-amine

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / 1,2-dichloro-benzene / 90 °C
2.1: acetone; water / 3 h / 50 °C
2.2: 5 h / 0 - 5 °C / Reflux
3.1: sodium hydroxide / dichloromethane; water / 0.5 h / 25 °C / pH 10
3.2: 2.5 h / 0 °C / pH 2
View Scheme
1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane
847063-13-2

1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 2 h / 45 - 60 °C
2.1: aluminum (III) chloride / 1,2-dichloro-benzene / 3 h / 125 - 130 °C
3.1: L-Tartaric acid / acetone; water / 0.5 h / 45 - 50 °C
4.1: potassium carbonate / water / 0.33 h / 10 - 25 °C
4.2: 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1.1: thionyl chloride / toluene / 10 h / 70 °C
2.1: aluminum (III) chloride / 1,2-dichloro-benzene / 10 h / 140 °C
3.1: L-Tartaric acid / ethanol; water / 80 °C
3.2: pH 12
3.3: 1 h / 5 - 10 °C
View Scheme
1-((2-(4-chlorophenyl)ethyl)amino)-2-chloropropane hydrochloride
953789-37-2

1-((2-(4-chlorophenyl)ethyl)amino)-2-chloropropane hydrochloride

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / 1,2-dichloro-benzene / 3 h / 125 - 130 °C
2.1: L-Tartaric acid / acetone; water / 0.5 h / 45 - 50 °C
3.1: potassium carbonate / water / 0.33 h / 10 - 25 °C
3.2: 0 - 5 °C
View Scheme
(R)-N-tert-butoxycarbonyl-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
851477-82-2

(R)-N-tert-butoxycarbonyl-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; water1.8 g
2-(2-bromo-4-chlorophenyl)ethan-1-amine
1202889-65-3

2-(2-bromo-4-chlorophenyl)ethan-1-amine

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: ethanol / 0.5 h
1.2: 1 h / Cooling with ice
2.1: methanol / 3 h
3.1: triethylamine / acetonitrile / 10 h / 80 °C / Inert atmosphere
4.1: palladium on activated charcoal; hydrogen; dimethylsulfide; thiourea / quinoline / 4 h / 3750.38 Torr
5.1: hydrogenchloride / methanol; water
View Scheme
C11H13BrClN

C11H13BrClN

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: methanol / 3 h
2: triethylamine / acetonitrile / 10 h / 80 °C / Inert atmosphere
3: palladium on activated charcoal; hydrogen; dimethylsulfide; thiourea / quinoline / 4 h / 3750.38 Torr
4: hydrogenchloride / methanol; water
View Scheme
C16H21BrClNO2

C16H21BrClNO2

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / acetonitrile / 10 h / 80 °C / Inert atmosphere
2: palladium on activated charcoal; hydrogen; dimethylsulfide; thiourea / quinoline / 4 h / 3750.38 Torr
3: hydrogenchloride / methanol; water
View Scheme
(±)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
1431697-94-7

(±)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

A

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

B

(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

Conditions
ConditionsYield
With Chiralpak IA column In methanol; ethanol; hexane; diethylamine at 20℃; Temperature; Resolution of racemate;
(R)-2-chloro-N-(2-(3-chlorophenyl)propyl)acetamide

(R)-2-chloro-N-(2-(3-chlorophenyl)propyl)acetamide

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: borane-THF / tetrahydrofuran / 15 h / 25 °C
1.2: 1 h / 5 - 25 °C
2.1: aluminum (III) chloride / neat (no solvent) / 150 °C
3.1: hydrogenchloride / diethyl ether; water; dichloromethane
View Scheme
(R)-N-(2-(3-chlorophenyl)propyl)-N-(2,2-dimethoxyethyl)-4-methyl benzenesulfonamide

(R)-N-(2-(3-chlorophenyl)propyl)-N-(2,2-dimethoxyethyl)-4-methyl benzenesulfonamide

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
2: hydrogenchloride; platinum(IV) oxide; hydrogen / water; methanol / 48 h / 25 °C / 3750.38 Torr
3: phenol; hydrogen bromide; propionic acid / 6 h / Reflux
4: hydrogenchloride / diethyl ether; water; dichloromethane
View Scheme
N-(2-(3-chlorophenyl)propyl)-N-(2,2-dimethoxyethyl)-4-methylbenzene sulfonamide

N-(2-(3-chlorophenyl)propyl)-N-(2,2-dimethoxyethyl)-4-methylbenzene sulfonamide

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride; platinum(IV) oxide; hydrogen / water; methanol / 48 h / 25 °C / 3750.38 Torr
2: phenol; hydrogen bromide; propionic acid / 6 h / Reflux
3: hydrogenchloride / diethyl ether; water; dichloromethane
View Scheme
(R)-2-(3-chlorophenyl)propan-2-amine hydrochloride salt

(R)-2-(3-chlorophenyl)propan-2-amine hydrochloride salt

Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water
2.1: sodium carbonate / dichloromethane / 0.25 h / 5 - 10 °C
2.2: 25 °C
3.1: borane-THF / tetrahydrofuran / 15 h / 25 °C
3.2: 1 h / 5 - 25 °C
4.1: aluminum (III) chloride / neat (no solvent) / 150 °C
5.1: hydrogenchloride / diethyl ether; water; dichloromethane
View Scheme
Multi-step reaction with 7 steps
1: sodium hydroxide / water
2: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Inert atmosphere
3: pyridine / dichloromethane / 2.5 h / 0 - 20 °C
4: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
5: hydrogenchloride; platinum(IV) oxide; hydrogen / water; methanol / 48 h / 25 °C / 3750.38 Torr
6: phenol; hydrogen bromide; propionic acid / 6 h / Reflux
7: hydrogenchloride / diethyl ether; water; dichloromethane
View Scheme
Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

acrylonitrile
107-13-1

acrylonitrile

(R)-3-(8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)propanenitrile

(R)-3-(8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)propanenitrile

Conditions
ConditionsYield
With sodium In methanol at 55℃; for 12h; Inert atmosphere;96%
Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

benzoic acid
65-85-0

benzoic acid

C11H14ClN*ClH*C7H6O2

C11H14ClN*ClH*C7H6O2

Conditions
ConditionsYield
In acetone Solvent;94.7%
Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine 3-carboxylic acid 2-chloroethyl ester

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine 3-carboxylic acid 2-chloroethyl ester

Conditions
ConditionsYield
Stage #1: Lorcaserin hydrochloride With triethylamine In dichloromethane at 0℃; for 0.166667h;
Stage #2: 2-Chloroethyl chloroformate In dichloromethane at 0℃; for 2h;
94.5%
Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

D-(+)-camphoric acid
124-83-4

D-(+)-camphoric acid

(R)-lorcaserin hydrochloride (1R,3S)-(+)-camphoric acid

(R)-lorcaserin hydrochloride (1R,3S)-(+)-camphoric acid

Conditions
ConditionsYield
at 20 - 25℃; Concentration; Temperature; Reflux;81%
Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-3-carboxylic acid 2-(diethylamino)ethyl ester

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-3-carboxylic acid 2-(diethylamino)ethyl ester

Conditions
ConditionsYield
Stage #1: 1,1'-carbonyldiimidazole; 2-(Diethylamino)ethanol In dichloromethane at 0 - 20℃; for 5.16667h; Inert atmosphere;
Stage #2: Lorcaserin hydrochloride In dichloromethane at 20℃;
80.4%
Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

1-Bromo-4-phenylbutane
13633-25-5

1-Bromo-4-phenylbutane

C21H26ClN

C21H26ClN

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 90℃; for 18h; Sealed tube;70%
Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

oxalic acid
144-62-7

oxalic acid

(R)-lorcaserin hydrochloride oxalic acid

(R)-lorcaserin hydrochloride oxalic acid

Conditions
ConditionsYield
Stage #1: Lorcaserin hydrochloride With sodium hydroxide In water pH=10;
Stage #2: oxalic acid With hydrogenchloride In ethyl acetate at 20 - 25℃; Concentration; Reagent/catalyst; pH-value; Temperature; Solvent;
68%
Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

(1R)-N-trifluoroacetyl-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine
616202-89-2

(1R)-N-trifluoroacetyl-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 3h;
Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

acetyl chloride
75-36-5

acetyl chloride

(R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone
1181690-72-1

(R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 0.5h;
Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

methoxypropionyl chloride
4244-59-1

methoxypropionyl chloride

3-methoxy-1-((R)-1-methyl-8-(4-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)phenyl)-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)propan-1-one
1181691-01-9

3-methoxy-1-((R)-1-methyl-8-(4-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)phenyl)-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)propan-1-one

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 4h;
Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

(R)-8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-sulfonic acid

(R)-8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-sulfonic acid

Conditions
ConditionsYield
With human sulfotransferase; 3′-phosphoadenosine 5′-phosphosulfate In aq. buffer at 37℃; for 0.05h; pH=7.5; Reagent/catalyst; Enzymatic reaction;

Raw Materials

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