Lorcaserin A supplier | CasNO.616201-80-0

Name
LorcaserinA
EINECS 1312995-182-4
CAS No. 616201-80-0
Article Data30
CAS DataBase
Density 1.075g/cm³
Solubility
Melting Point
Formula C₁₁H₁₄Cl N
Boiling Point 288ºC
Molecular Weight 195.692
Flash Point 128 ºC
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms (?à)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine;8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine;
PSA 12.03000
LogP 2.91800

Synthetic route

: 953789-37-2
1-((2-(4-chlorophenyl)ethyl)amino)-2-chloropropane hydrochloride

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
With aluminum (III) chloride In 1,2-dichloro-benzene at 120 - 125℃; Inert atmosphere;	99%
With aluminum (III) chloride at 120 - 125℃; for 3h; Inert atmosphere; Large scale;	97%
With aluminum (III) chloride In 1,2-dichloro-benzene at 135 - 140℃;	96.1%

: N-(4-chlorophenylethyl)propyl-2-ene-1-amine hydrochloride

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; for 4h; Solvent; Temperature; Reagent/catalyst; Friedel-Crafts Alkylation; Inert atmosphere; Large scale;	92.3%
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; Friedel-Crafts Alkylation;	84.5%
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃;	84.5%
With zinc(II) chloride at 125℃; for 6.41667h; Reagent/catalyst; Friedel-Crafts Alkylation;	230 mg

: N-(4-chlorophenylethyl)propyl-2-ene-1-amine trifluoroacetate

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃; Friedel-Crafts Alkylation;	83.9%
With aluminum (III) chloride In 1,2-dichloro-benzene at 110℃;	83.9%

: 1247548-14-6
N-(4-chlorophenylethyl)propyl-2-ene-1-amine

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
With aluminum (III) chloride In 1,2-dichloro-benzene at 90℃; Friedel-Crafts Alkylation;	82.1%
With aluminum (III) chloride at 125℃; for 6.41667h; Friedel-Crafts Alkylation;	230 mg

: N-allyl-N-(4-chlorophenethyl)carbamic acid tert-butyl ester

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
With aluminum (III) chloride In chlorobenzene at 110℃; Solvent; Temperature;	81.6%
Multi-step reaction with 2 steps 1: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale 2: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale View Scheme
Multi-step reaction with 2 steps 1: hydrogenchloride / ethyl acetate / 20 °C 2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme
Multi-step reaction with 2 steps 1: dichloromethane / 25 °C 2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme
Multi-step reaction with 2 steps 1: hydrogenchloride / water; ethyl acetate / 20 °C 2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme

: 824430-77-5
8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
With borane-THF at 20℃; for 10h;	70%
With borane In diethyl ether
With sodium tetrahydroborate; chloro-trimethyl-silane In 1,2-dichloro-ethane at 70℃; for 20h; Solvent; Temperature; Cooling with ice;	0.89 g

: 34164-14-2
N-(4-chlorophenylethyl)-2-chloropropanamide

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 / 150 - 200 °C 2: BH3 / diethyl ether View Scheme
Multi-step reaction with 2 steps 1: aluminum (III) chloride / 8 h / 150 °C 2: chloro-trimethyl-silane; sodium tetrahydroborate / 1,2-dichloro-ethane / 20 h / 70 °C / Cooling with ice View Scheme

: 156-41-2
4-chlorophenylethylamine

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridine / CH2Cl2 2: AlCl3 / 150 - 200 °C 3: BH3 / diethyl ether View Scheme
Multi-step reaction with 2 steps 1: potassium carbonate / tetrahydrofuran / 18 h / 20 °C 2: zinc(II) chloride / 6.42 h / 125 °C View Scheme
Multi-step reaction with 4 steps 1: dmap / dichloromethane / 0 - 20 °C / Large scale 2: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 5 h / 80 °C / Large scale 3: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale 4: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale View Scheme

: 616202-51-8
(1R,S)-N-trifluoroacetyl-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 60℃; for 3.5h;	35 mg
With sodium hydroxide In methanol
With sodium hydroxide In methanol; water at 60℃; for 3.5h;

: 953789-37-2
1-((2-(4-chlorophenyl)ethyl)amino)-2-chloropropane hydrochloride

: 95-50-1
1,2-dichloro-benzene

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Stage #1: 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride; 1,2-dichloro-benzene With aluminum (III) chloride at 126℃; for 16h; Friedel Crafts; Industry scale; Inert atmosphere; Stage #2: With sodium hydroxide In cyclohexane; water pH=12; Product distribution / selectivity; Industry scale;

: 6529-53-9
1-(2-bromoethyl)-4-chlorobenzene

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Reflux 2: zinc(II) chloride / 6.42 h / 125 °C View Scheme

: 1875-88-3
2-(4-Chlorophenyl)ethanol

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: triethylamine; dmap / dichloromethane / 4 h 2.1: dichloromethane / Reflux 2.2: Reflux 3.1: zinc(II) chloride / 6.42 h / 125 °C View Scheme

: N-(2-chloroethyl)-2-(3-chlorophenyl ) propan-1-amine

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
With aluminum (III) chloride at 150℃;

: 1082555-06-3
2-(3-chlorophenyl) propan-1-amine

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Inert atmosphere 2: pyridine / dichloromethane / 2.5 h / 20 °C 3: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere 4: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr 5: hydrogen bromide; phenol; propionic acid / 6 h / Reflux View Scheme

Yield

Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Inert atmosphere
2: pyridine / dichloromethane / 2.5 h / 20 °C
3: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
4: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr
5: hydrogen bromide; phenol; propionic acid / 6 h / Reflux
View Scheme

: 1616729-45-3
2-(3-chlorophenyl)-N-(2,2-dimethoxyethyl)propan-1-amine

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: pyridine / dichloromethane / 2.5 h / 20 °C 2: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere 3: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr 4: hydrogen bromide; phenol; propionic acid / 6 h / Reflux View Scheme

: N-(2-(3-chlorophenyl)propyl)-N-(2,2-dimethoxyethyl)-4-methylbenzenesulfonamide

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere 2: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr 3: hydrogen bromide; phenol; propionic acid / 6 h / Reflux View Scheme

: 8-chloro-1-methyl-3-tosyl-2,3-dihydro-1H-benzo[d]azepine

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen; platinum(IV) oxide; hydrogenchloride / methanol / 48 h / 25 °C / 3750.38 Torr 2: hydrogen bromide; phenol; propionic acid / 6 h / Reflux View Scheme

: 8-chloro-1-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
With hydrogen bromide; propionic acid; phenol for 6h; Reflux;

: (S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

: 2937-50-0
Allyl chloroformate

A: allyl (S)-8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-carboxylate

B: allyl (R)-8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-carboxylate

C: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Stage #1: (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride; Allyl chloroformate With triethylamine In dichloromethane at 0 - 20℃; Stage #2: With potassium tert-butylate In dimethyl sulfoxide at 100℃;	A n/a B n/a C 28 %Spectr.

...Expand

: 616202-81-4
(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
With potassium tert-butylate In dimethyl sulfoxide at 90℃; Reagent/catalyst; Temperature;

: (S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

A: 1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

B: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C 2: potassium tert-butylate / dimethyl sulfoxide / 100 °C View Scheme

: (S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

A: 1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-yl)-2-phenylethanone

B: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate / acetone; water / 0 - 20 °C 2: sodium hydroxide / dimethyl sulfoxide / 100 °C View Scheme

: (S)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

A: 1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

B: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
With potassium tert-butylate In dimethyl sulfoxide at 100℃; Reagent/catalyst;	A n/a B 12 %Spectr.

: (S)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-yl)-2-phenylethanone

A: 1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepine-3(2H)-yl)-2-phenylethanone

B: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
With sodium hydroxide In dimethyl sulfoxide at 100℃;	A n/a B 25 %Spectr.

: 167886-56-8
1-[2-(tert-butoxycarbonylamino)ethyl]4-chlorobenzene

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 5 h / 80 °C / Large scale 2: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale 3: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale View Scheme
Multi-step reaction with 3 steps 1: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 80 °C 2: dichloromethane / 25 °C 3: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme
Multi-step reaction with 3 steps 1: potassium carbonate; potassium hydroxide; tetrabutylammomium bromide / toluene / 80 °C 2: hydrogenchloride / ethyl acetate / 20 °C 3: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C View Scheme

: 4-chloro-N-(2-chloro-1-oxopropyl)benzeneacetamide

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; aluminum (III) chloride; chloro-trimethyl-silane / tetrahydrofuran / 24 h / 70 °C / Inert atmosphere 2: aluminum (III) chloride / 1,2-dichloro-benzene / 16 h / 130 °C View Scheme

: 1878-66-6
4-chlorophenylacetic Acid

: 616201-80-0
(+/-)-Lorcaserin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: boric acid / toluene / 24 h / 40 - 135 °C 2: dimethylsulfide borane complex / tetrahydrofuran / 2.75 h / 8 - 45 °C 3: aluminum (III) chloride / 1,2-dichloro-benzene / 8 h / 5 - 125 °C View Scheme

: 616201-80-0
(+/-)-Lorcaserin

: 846589-98-8
Lorcaserin hydrochloride

Conditions

Conditions	Yield
Stage #1: (+/-)-Lorcaserin With L-Tartaric acid In ethanol; water at 80℃; Stage #2: With potassium carbonate In water pH=12; Stage #3: With hydrogenchloride In water; ethyl acetate at 5 - 10℃; for 1h;	80%
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: hydrogenchloride / ethyl acetate; water / pH 5 / Industry scale View Scheme
Multi-step reaction with 2 steps 1.1: water; tert-butyl alcohol / 10 h / 20 °C 2.1: sodium hydroxide / water / 0.17 h / 20 °C 2.2: 0.08 h / 20 °C View Scheme

: 87-69-4
L-Tartaric acid

: 616201-80-0
(+/-)-Lorcaserin

: (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine L-(+)-tartrate

Conditions

Conditions	Yield
In water; tert-butyl alcohol at 20 - 78℃; for 4h;	48%
In water; acetone at 58℃; for 2h; Concentration;	37.1%
In acetone at 50℃; for 3h;	33.2%

: 616201-80-0
(+/-)-Lorcaserin

: bis((R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) L-(+)-tartarate

Conditions

Conditions	Yield
With L-Tartaric acid In water; acetone at 45 - 50℃; for 0.5h;	36.6%

: 87-69-4
L-Tartaric acid

: 616201-80-0
(+/-)-Lorcaserin

: bis((R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) L-(+)-tartarate

Conditions

Conditions	Yield
In water; acetone at 50℃; for 3h; Large scale;	33.2%
Stage #1: L-Tartaric acid; (+/-)-Lorcaserin In water; acetone at 50℃; for 3h; Stage #2: In water; acetone at 0 - 5℃; for 5h; Reflux;	32.8%
In water; acetone at 45 - 50℃; for 3h;	17.9%
In water; acetone at 47 - 52℃; for 0.0833333 - 0.25h; L-(+)-tartaric acid salt of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; Resolution of racemate;	n/a

: 87-69-4
L-Tartaric acid

: 616201-80-0
(+/-)-Lorcaserin

: 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine L-hemitartrate

Conditions

Conditions	Yield
In water; acetone at 0 - 52℃; for 2.08 - 3.25h;	27.1%

: 87-69-4
L-Tartaric acid

: 616201-80-0
(+/-)-Lorcaserin

: 2C11H14ClN*C4H6O6

Conditions

Conditions	Yield
In water; acetone at 0 - 55℃;	24.1%

: 847063-13-2
1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane

: 616201-80-0
(+/-)-Lorcaserin

: 2-(8-chloro-1-methyl-4,5-dihydro-1H-benzazepin-3(2H)-yl)-N-(4-chlorophenethyl)propan-1-amine hydrochloride

Conditions

Conditions	Yield
Stage #1: 1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane; (+/-)-Lorcaserin With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 70 - 75℃; for 5h; Stage #2: With isopropyl alcohol hydrogen chloride at 0 - 5℃; for 1h;	18.3%

: 616201-80-0
(+/-)-Lorcaserin

: (S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine hydrochloride

Conditions

Conditions	Yield
Stage #1: (+/-)-Lorcaserin With L-Tartaric acid In water; acetone at 45 - 50℃; for 3h; Stage #2: With ammonium hydroxide In water; ethyl acetate for 0.5h; pH=> 10; Further stages;	17.9%

: 616201-80-0
(+/-)-Lorcaserin

A: 616202-81-4
(S)-8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepine

B: lorcaserin

Conditions

Conditions	Yield
chiral HPLC;

: 87-69-4
L-Tartaric acid

: 616201-80-0
(+/-)-Lorcaserin

: (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemitartrate

Conditions

Conditions	Yield
In water; acetone at 47 - 52℃; for 2 - 3h;	n/a
In water; acetone at 45℃; for 0.333333h; Temperature; Large scale;	158 kg

: 87-69-4
L-Tartaric acid

: 616201-80-0
(+/-)-Lorcaserin

: (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemitartrate

Conditions

Conditions	Yield
In water; acetone at 45℃; for 0.333333h; Product distribution / selectivity; Industry scale;

: 616201-80-0
(+/-)-Lorcaserin

: 1361475-96-8
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine adipate salt

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: acetone / 0.08 h / 62 °C View Scheme

: 616201-80-0
(+/-)-Lorcaserin

: 1361475-98-0
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine malonate salt

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: Isopropyl acetate View Scheme

: 616201-80-0
(+/-)-Lorcaserin

: 1361476-04-1
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine glycolate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: 60 °C / Cooling View Scheme

: 616201-80-0
(+/-)-Lorcaserin

: 1361475-79-7
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine bisulfate salt

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: sulfuric acid View Scheme

: 616201-80-0
(+/-)-Lorcaserin

: (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hemisulfate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: sulfuric acid View Scheme

: 616201-80-0
(+/-)-Lorcaserin

: 1361476-15-4
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: hydrogen bromide / water / 38 °C / Inert atmosphere View Scheme

: 616201-80-0
(+/-)-Lorcaserin

: 1361475-85-5
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine mesylate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: 20 - 60 °C View Scheme

: 616201-80-0
(+/-)-Lorcaserin

: 1361475-90-2
(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine nitrate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water; acetone / 0.33 h / 45 °C / Industry scale 2: potassium carbonate / ethyl acetate; water / 15 - 22 °C / Industry scale 3: nitric acid / water View Scheme

Lorcaserin A Chemical Properties

Product Name: LorcaserinA
Synonyms of LorcaserinA (CAS NO.616201-80-0): 8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine
CAS NO: 616201-80-0
Molecular Formula of LorcaserinA (CAS NO.616201-80-0): C₁₁H₁₄ClN
Molecular Weight: 195.69
Molecular Structure:

Boiling Point: 288 º C
Density of LorcaserinA (CAS NO.616201-80-0): 1.075g/cm³
Flash Point: 128 º C

Product Name

LorcaserinA

Synthetic route

Lorcaserin A Chemical Properties

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