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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Colchicine

Cas:64-86-8

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Colchicine/ LIDE PHARMA- Factory supply / Best price

Cas:64-86-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Greenutra Resource Inc

Colchicum autumnale Extract with colchicine 98% Colchicine is an ancient remedy for the treatment of articular pain. Use of Colchicum alkaloid for the treatment of acute gout occurred as early as 1810, and reports of its medicinal value exist

Colchicum autumnale Extract with colchicine 98%

Cas:64-86-8

Min.Order:1 Kilogram

FOB Price: $19.0

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Colchicine Manufacturer/High quality/Best price/In stock

Cas:64-86-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Colchicine 64-86-8

Cas:64-86-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Description Pale Yellow to pale greenish-yellow, amorphous scales or crystalline powder. Is odorless or nearly so and darkens on e

High quality Colchicine with best price cas:64-86-8

Cas:64-86-8

Min.Order:1 Kilogram

FOB Price: $250.0 / 350.0

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Superiority pioneerbiotech is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best q

Colchicine

Cas:64-86-8

Min.Order:1 Gram

FOB Price: $800.0 / 1000.0

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Colchicine CAS NO.64-86-8

Cas:64-86-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Xi'an Quanao Biotech Co., Ltd.

Control gout light yellow powder natural Colchicum Autumnale Extract Colchicine Powder Professional Factory We has a complete production and operating system, with an annual output capacity of 2000 tons. It can produce variety of content and propor

Control gout light yellow powder natural Colchicum Autumnale Extract Colchicine Powder

Cas:64-86-8

Min.Order:100 Kilogram

FOB Price: $155.0 / 159.0

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Colchicine manufacturer with low price

Cas:64-86-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Colchicine

Cas:64-86-8

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Xi`an Eastling Biotech Co., Ltd.

F Colchicine CAS: 64-86-8 Molecular Formula: C22H25NO6 Home Product Category other other 64-86-8 64-86-8 - Names and Identifiers Name Colchicine Synonyms Colchicine len-7-yl)- Colchicine 64-86-8 Colchicin

Top Quality Natural Colchicine

Cas:64-86-8

Min.Order:1 Kilogram

FOB Price: $35.0 / 49.0

Type:Lab/Research institutions

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Colchicine

Cas:64-86-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Colchicine

Cas:64-86-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:colchicine Name:colchicine CAS no:64-86-8 Grade:Chemical industry, scientific research and export Molecular formula:C22H25NO6 Molecular weight:399.437 Product Quality 12 years of chemical raw materials Mature operation of t

colchicine/cas:64-86-8/colchicine material/high-quality

Cas:64-86-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

cas 64-86-8 Demecolcine

Cas:64-86-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 64-86-8 with competitive price

Cas:64-86-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name Colchicine Synonyms (S)-N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO[A]HEPTALEN-7-YL)ACETAMIDE;N-((S)-1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL)-ACET

Colchicine

Cas:64-86-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:Light yellow crystal Storage:storag

Hotsale Colchicine 99%CAS NO.64-86-8

Cas:64-86-8

Min.Order:1 Gram

FOB Price: $9.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Top quality Colchicine from Local factory / CAS No.: 64-86-8

Cas:64-86-8

Min.Order:1 Kilogram

FOB Price: $20.0 / 500.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Colchicine CAS 64-86-8 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and exp

High quality Colchicine CAS 64-86-8

Cas:64-86-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Acetamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

Cas:64-86-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Colchicine Synonyms: Colchicine Acetamide 64-86-8;IMp. D (EP): N-[(7S,12aRa)-3-(β-D-Glucopyranosyloxy)-1,2,10-triMethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetaMide (Colchicoside);N-[(7S)-1,2,3,10-tetraMethoxy-9-ox

Colchicine big supplier with lower price

Cas:64-86-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Colchicine CAS: 64-86-8 Specification Appearance & Physical State yellow powder Density 1.32 g/cm3 Melting Point 150-160ºC Flash Point 392.9ºC Refractive Index 1.584

Factory supply Colchicine

Cas:64-86-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Acetamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

Cas:64-86-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

High Purity Colchicine Low Price CAS 64-86-8

Cas:64-86-8

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Colchicine

Cas:64-86-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Colchicine

Cas:64-86-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Colchicine 64-86-8

Cas:64-86-8

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

acetic anhydride
108-24-7

acetic anhydride

(S)-tert-butyl N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalene-7-yl)carbamate
186374-95-8

(S)-tert-butyl N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalene-7-yl)carbamate

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Stage #1: (S)-tert-butyl N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalene-7-yl)carbamate With hydrogenchloride In diethyl ether at 20℃; for 1h;
Stage #2: acetic anhydride With dmap; triethylamine In diethyl ether at 25℃; for 10h;
98%
methoxymagnesium bromide

methoxymagnesium bromide

10-demethoxy-10-tosylcolchicine

10-demethoxy-10-tosylcolchicine

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
In tetrahydrofuran for 5h;85%
C22H27NO7

C22H27NO7

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
With N,N-dimethyl-ethanamine; trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 12h; Inert atmosphere;81%
With N,N-dimethyl-ethanamine; trimethylsilyl trifluoromethanesulfonate In dichloromethane81%
With trimethylsilyl trifluoromethanesulfonate; triethylamine In dichloromethane at 20℃; for 2h;75%
magnesium methanolate
109-88-6, 16436-83-2, 16436-85-4

magnesium methanolate

10-demethoxy-10-tosylcolchicine

10-demethoxy-10-tosylcolchicine

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
In methanol78%
diethyl ether
60-29-7

diethyl ether

chloroform
67-66-3

chloroform

A

colchicine
64-86-8

colchicine

B

(7S)-isocolchicine
518-12-7

(7S)-isocolchicine

A

colchicine
64-86-8

colchicine

B

(7S)-isocolchicine
518-12-7

(7S)-isocolchicine

Conditions
ConditionsYield
With diethyl ether; chloroform
2,10-didemethylcolchicine
33530-04-0

2,10-didemethylcolchicine

A

colchicine
64-86-8

colchicine

B

2-demethylcolchicine
7336-36-9

2-demethylcolchicine

C

(7S)-isocolchicine
518-12-7

(7S)-isocolchicine

D

2-demethylisocolchicine
142713-50-6

2-demethylisocolchicine

Conditions
ConditionsYield
In diethyl ether; chloroform
<1-3H>-3-phenylpropanal
133946-40-4

<1-3H>-3-phenylpropanal

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Colchicum byzantinum biosynthesis;
<3-14C>-cinnamic acid
4469-06-1

<3-14C>-cinnamic acid

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Colchicum byzantinum biosynthesis;
deacetylcolchicine
3476-50-4

deacetylcolchicine

acetic anhydride
108-24-7

acetic anhydride

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
With sodium hydrogencarbonate In chloroform; water for 2.5h;
Acetylation;
<1-3H>-3-phenylprop-2-enal
133946-39-1

<1-3H>-3-phenylprop-2-enal

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Colchicum byzantinum biosynthesis;
<3-14C>-3-phenylpropionic acid
131946-50-4

<3-14C>-3-phenylpropionic acid

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Colchicum byzantinum biosynthesis;
DL-phenylalanine
13744-69-9

DL-phenylalanine

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Colchicum byzantinum biosynthesis;
colchicine-β-cyclodextrin complex

colchicine-β-cyclodextrin complex

A

colchicine
64-86-8

colchicine

B

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

Conditions
ConditionsYield
at 25 - 60℃; Equilibrium constant;
(-)-O2-demethyl-colchicine

(-)-O2-demethyl-colchicine

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
With methanol; diethyl ether
(-)-O3-demethyl-colchicine

(-)-O3-demethyl-colchicine

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
With methanol; diethyl ether
3-(3,4,5-trimethoxyphenyl)propan-1-ol
53560-26-2

3-(3,4,5-trimethoxyphenyl)propan-1-ol

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Multi-step reaction with 17 steps
1.1: 98 percent / 2,6-lutidine / CH2Cl2 / 5 h / 20 °C
2.1: 95 percent / silver trifluoroacetate; I2; sodium bicarbonate / CHCl3 / 3 h / 0 °C
3.1: 92 percent / Et2NH; bis[triphenylphosphine]palladium dichloride; copper(I) iodide / dimethylsulfoxide / 20 h / 90 °C
4.1: 98 percent / n-Bu4NF / tetrahydrofuran / 7 h / 20 °C
5.1: 96 percent / oxalyl chloride; DMSO / CH2Cl2 / 0.75 h / -78 °C
6.1: BH3*THF / tetrahydrofuran / 1 h / 20 °C
6.2: t-BuLi / pentane; tetrahydrofuran / 0.67 h / -78 °C
6.3: 64 percent / tetrahydrofuran; pentane / 3 h / -78 °C
7.1: 96 percent / oxalyl chloride; DMSO / CH2Cl2 / 0.5 h / -78 °C
8.1: 85 percent / BH3*THF; (S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol / tetrahydrofuran / 6 h / 23 °C
9.1: 60 percent / diphenylphosphoryl azide; triphenylphosphine; diisopropylazodicarboxylate / tetrahydrofuran / 12 h / 20 °C
10.1: 95 percent / Ph3P / tetrahydrofuran; H2O / 50 h / 20 °C
11.1: 98 percent / DMAP; Et3N / diethyl ether / 7 h / 20 °C
12.1: 60 percent / various solvent(s) / 66 h / Heating
13.1: 99 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / 35 °C
14.1: 99 percent / aq. LiOH / tetrahydrofuran / 12 h
15.1: 45 percent Turnov. / trimethylsilyltriflate / various solvent(s) / -78 - -60 °C
16.1: 62 percent / Et3N; trimethylsilyl triflate / CH2Cl2 / 2 h / 0 °C
17.1: HCl / diethyl ether / 1 h / 20 °C
17.2: 98 percent / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h / 25 °C
View Scheme
Multi-step reaction with 18 steps
1: 2,6-lutidine
2: I2; CF3CO2Ag / CHCl3
3: Et2NH; CuI / (Ph3P)2PdCl2 / dimethylsulfoxide
4: TBAF / tetrahydrofuran
5: (COCl)2; DMSO; Et3N
7: (COCl)2; DMSO; Et3N
9: 64 percent / PPh3; DEAD; (PhO)2P(O)N3
10: Ph3P; H2O
11: Et3N
12: 70 percent / 1,2-dichloro-benzene / Heating
13: LiOH
15: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C
16: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C
17: HCl
View Scheme
3,4,5-Trimethoxybenzoyl chloride
4521-61-3

3,4,5-Trimethoxybenzoyl chloride

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Multi-step reaction with 15 steps
1.1: zinc-copper couple / benzene; N,N-dimethyl-acetamide / 3 h / 20 °C / sonication
1.2: 31 percent / bis(triphenylphosphine)palladium dichloride / benzene; N,N-dimethyl-acetamide / 2 h / sonication
2.1: 91 percent / H2 / Pd/C / ethanol; H2O / 22 h / 3102.89 Torr
3.1: 93 percent / NaHCO3; silver trifluoroacetate; I2 / CHCl3 / 2 h / 0 °C
4.1: trifluoroacetic acid / diethyl ether / 3 h / 20 °C
5.1: 454 mg / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h
6.1: 60 percent / Et2NH; bis[triphenylphosphine]palladium dichloride; copper(I) iodide / dimethylsulfoxide / 15 h / 90 °C
7.1: 91 percent / potassium carbonate / methanol / 11 h / 20 °C
8.1: 100 percent / DIBAL / CH2Cl2; hexane / 1 h / -78 °C
9.1: potassium carbonate / methanol / 1 h / Heating
9.2: 64 percent / KOH / methanol / 3 h / Heating
10.1: 70 percent / various solvent(s) / 40 h / Heating
11.1: 99 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / 35 °C
12.1: 99 percent / aq. LiOH / tetrahydrofuran / 12 h
13.1: 45 percent Turnov. / trimethylsilyltriflate / various solvent(s) / -78 - -60 °C
14.1: 62 percent / Et3N; trimethylsilyl triflate / CH2Cl2 / 2 h / 0 °C
15.1: HCl / diethyl ether / 1 h / 20 °C
15.2: 98 percent / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h / 25 °C
View Scheme
3-(2-ethynyl-3,4,5-trimethoxy-phenyl)-propionaldehyde
327024-99-7

3-(2-ethynyl-3,4,5-trimethoxy-phenyl)-propionaldehyde

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: BH3*THF / tetrahydrofuran / 1 h / 20 °C
1.2: t-BuLi / pentane; tetrahydrofuran / 0.67 h / -78 °C
1.3: 64 percent / tetrahydrofuran; pentane / 3 h / -78 °C
2.1: 96 percent / oxalyl chloride; DMSO / CH2Cl2 / 0.5 h / -78 °C
3.1: 85 percent / BH3*THF; (S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol / tetrahydrofuran / 6 h / 23 °C
4.1: 60 percent / diphenylphosphoryl azide; triphenylphosphine; diisopropylazodicarboxylate / tetrahydrofuran / 12 h / 20 °C
5.1: 95 percent / Ph3P / tetrahydrofuran; H2O / 50 h / 20 °C
6.1: 98 percent / DMAP; Et3N / diethyl ether / 7 h / 20 °C
7.1: 60 percent / various solvent(s) / 66 h / Heating
8.1: 99 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / 35 °C
9.1: 99 percent / aq. LiOH / tetrahydrofuran / 12 h
10.1: 45 percent Turnov. / trimethylsilyltriflate / various solvent(s) / -78 - -60 °C
11.1: 62 percent / Et3N; trimethylsilyl triflate / CH2Cl2 / 2 h / 0 °C
12.1: HCl / diethyl ether / 1 h / 20 °C
12.2: 98 percent / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h / 25 °C
View Scheme
Multi-step reaction with 13 steps
2: (COCl)2; DMSO; Et3N
4: 64 percent / PPh3; DEAD; (PhO)2P(O)N3
5: Ph3P; H2O
6: Et3N
7: 70 percent / 1,2-dichloro-benzene / Heating
8: LiOH
10: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C
11: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C
12: HCl
View Scheme
3-(2-ethynyl-3,4,5-trimethoxyphenyl)propan-1-ol
206195-25-7

3-(2-ethynyl-3,4,5-trimethoxyphenyl)propan-1-ol

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1.1: 96 percent / oxalyl chloride; DMSO / CH2Cl2 / 0.75 h / -78 °C
2.1: BH3*THF / tetrahydrofuran / 1 h / 20 °C
2.2: t-BuLi / pentane; tetrahydrofuran / 0.67 h / -78 °C
2.3: 64 percent / tetrahydrofuran; pentane / 3 h / -78 °C
3.1: 96 percent / oxalyl chloride; DMSO / CH2Cl2 / 0.5 h / -78 °C
4.1: 85 percent / BH3*THF; (S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol / tetrahydrofuran / 6 h / 23 °C
5.1: 60 percent / diphenylphosphoryl azide; triphenylphosphine; diisopropylazodicarboxylate / tetrahydrofuran / 12 h / 20 °C
6.1: 95 percent / Ph3P / tetrahydrofuran; H2O / 50 h / 20 °C
7.1: 98 percent / DMAP; Et3N / diethyl ether / 7 h / 20 °C
8.1: 60 percent / various solvent(s) / 66 h / Heating
9.1: 99 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / 35 °C
10.1: 99 percent / aq. LiOH / tetrahydrofuran / 12 h
11.1: 45 percent Turnov. / trimethylsilyltriflate / various solvent(s) / -78 - -60 °C
12.1: 62 percent / Et3N; trimethylsilyl triflate / CH2Cl2 / 2 h / 0 °C
13.1: HCl / diethyl ether / 1 h / 20 °C
13.2: 98 percent / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h / 25 °C
View Scheme
Multi-step reaction with 14 steps
1: (COCl)2; DMSO; Et3N
3: (COCl)2; DMSO; Et3N
5: 64 percent / PPh3; DEAD; (PhO)2P(O)N3
6: Ph3P; H2O
7: Et3N
8: 70 percent / 1,2-dichloro-benzene / Heating
9: LiOH
11: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C
12: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C
13: HCl
View Scheme
3-(2-ethynyl-3,4,5-trimethoxy-phenyl)-1-oxazol-2-yl-propan-1-one

3-(2-ethynyl-3,4,5-trimethoxy-phenyl)-1-oxazol-2-yl-propan-1-one

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: 85 percent / BH3*THF; (S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol / tetrahydrofuran / 6 h / 23 °C
2.1: 60 percent / diphenylphosphoryl azide; triphenylphosphine; diisopropylazodicarboxylate / tetrahydrofuran / 12 h / 20 °C
3.1: 95 percent / Ph3P / tetrahydrofuran; H2O / 50 h / 20 °C
4.1: 98 percent / DMAP; Et3N / diethyl ether / 7 h / 20 °C
5.1: 60 percent / various solvent(s) / 66 h / Heating
6.1: 99 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / 35 °C
7.1: 99 percent / aq. LiOH / tetrahydrofuran / 12 h
8.1: 45 percent Turnov. / trimethylsilyltriflate / various solvent(s) / -78 - -60 °C
9.1: 62 percent / Et3N; trimethylsilyl triflate / CH2Cl2 / 2 h / 0 °C
10.1: HCl / diethyl ether / 1 h / 20 °C
10.2: 98 percent / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h / 25 °C
View Scheme
Multi-step reaction with 11 steps
2: 64 percent / PPh3; DEAD; (PhO)2P(O)N3
3: Ph3P; H2O
4: Et3N
5: 70 percent / 1,2-dichloro-benzene / Heating
6: LiOH
8: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C
9: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C
10: HCl
View Scheme
3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(1,3-oxazol-2-yl)propan-1-ol
206195-28-0

3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(1,3-oxazol-2-yl)propan-1-ol

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: 96 percent / oxalyl chloride; DMSO / CH2Cl2 / 0.5 h / -78 °C
2.1: 85 percent / BH3*THF; (S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol / tetrahydrofuran / 6 h / 23 °C
3.1: 60 percent / diphenylphosphoryl azide; triphenylphosphine; diisopropylazodicarboxylate / tetrahydrofuran / 12 h / 20 °C
4.1: 95 percent / Ph3P / tetrahydrofuran; H2O / 50 h / 20 °C
5.1: 98 percent / DMAP; Et3N / diethyl ether / 7 h / 20 °C
6.1: 60 percent / various solvent(s) / 66 h / Heating
7.1: 99 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / 35 °C
8.1: 99 percent / aq. LiOH / tetrahydrofuran / 12 h
9.1: 45 percent Turnov. / trimethylsilyltriflate / various solvent(s) / -78 - -60 °C
10.1: 62 percent / Et3N; trimethylsilyl triflate / CH2Cl2 / 2 h / 0 °C
11.1: HCl / diethyl ether / 1 h / 20 °C
11.2: 98 percent / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h / 25 °C
View Scheme
Multi-step reaction with 12 steps
1: (COCl)2; DMSO; Et3N
3: 64 percent / PPh3; DEAD; (PhO)2P(O)N3
4: Ph3P; H2O
5: Et3N
6: 70 percent / 1,2-dichloro-benzene / Heating
7: LiOH
9: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C
10: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C
11: HCl
View Scheme
triisopropyl-[3-(3,4,5-trimethoxy-phenyl)-propoxy]-silane
327025-17-2

triisopropyl-[3-(3,4,5-trimethoxy-phenyl)-propoxy]-silane

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Multi-step reaction with 16 steps
1.1: 95 percent / silver trifluoroacetate; I2; sodium bicarbonate / CHCl3 / 3 h / 0 °C
2.1: 92 percent / Et2NH; bis[triphenylphosphine]palladium dichloride; copper(I) iodide / dimethylsulfoxide / 20 h / 90 °C
3.1: 98 percent / n-Bu4NF / tetrahydrofuran / 7 h / 20 °C
4.1: 96 percent / oxalyl chloride; DMSO / CH2Cl2 / 0.75 h / -78 °C
5.1: BH3*THF / tetrahydrofuran / 1 h / 20 °C
5.2: t-BuLi / pentane; tetrahydrofuran / 0.67 h / -78 °C
5.3: 64 percent / tetrahydrofuran; pentane / 3 h / -78 °C
6.1: 96 percent / oxalyl chloride; DMSO / CH2Cl2 / 0.5 h / -78 °C
7.1: 85 percent / BH3*THF; (S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol / tetrahydrofuran / 6 h / 23 °C
8.1: 60 percent / diphenylphosphoryl azide; triphenylphosphine; diisopropylazodicarboxylate / tetrahydrofuran / 12 h / 20 °C
9.1: 95 percent / Ph3P / tetrahydrofuran; H2O / 50 h / 20 °C
10.1: 98 percent / DMAP; Et3N / diethyl ether / 7 h / 20 °C
11.1: 60 percent / various solvent(s) / 66 h / Heating
12.1: 99 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / 35 °C
13.1: 99 percent / aq. LiOH / tetrahydrofuran / 12 h
14.1: 45 percent Turnov. / trimethylsilyltriflate / various solvent(s) / -78 - -60 °C
15.1: 62 percent / Et3N; trimethylsilyl triflate / CH2Cl2 / 2 h / 0 °C
16.1: HCl / diethyl ether / 1 h / 20 °C
16.2: 98 percent / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h / 25 °C
View Scheme
Multi-step reaction with 17 steps
1: I2; CF3CO2Ag / CHCl3
2: Et2NH; CuI / (Ph3P)2PdCl2 / dimethylsulfoxide
3: TBAF / tetrahydrofuran
4: (COCl)2; DMSO; Et3N
6: (COCl)2; DMSO; Et3N
8: 64 percent / PPh3; DEAD; (PhO)2P(O)N3
9: Ph3P; H2O
10: Et3N
11: 70 percent / 1,2-dichloro-benzene / Heating
12: LiOH
14: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C
15: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C
16: HCl
View Scheme
5-[(3S)-3-azido-3-(1,3-oxazol-2-yl)propyl]-4-ethynyl-1,2,3-trimethoxybenzene
206195-32-6

5-[(3S)-3-azido-3-(1,3-oxazol-2-yl)propyl]-4-ethynyl-1,2,3-trimethoxybenzene

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 95 percent / Ph3P / tetrahydrofuran; H2O / 50 h / 20 °C
2.1: 98 percent / DMAP; Et3N / diethyl ether / 7 h / 20 °C
3.1: 60 percent / various solvent(s) / 66 h / Heating
4.1: 99 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / 35 °C
5.1: 99 percent / aq. LiOH / tetrahydrofuran / 12 h
6.1: 45 percent Turnov. / trimethylsilyltriflate / various solvent(s) / -78 - -60 °C
7.1: 62 percent / Et3N; trimethylsilyl triflate / CH2Cl2 / 2 h / 0 °C
8.1: HCl / diethyl ether / 1 h / 20 °C
8.2: 98 percent / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h / 25 °C
View Scheme
Multi-step reaction with 9 steps
1: Ph3P; H2O
2: Et3N
3: 70 percent / 1,2-dichloro-benzene / Heating
4: LiOH
6: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C
7: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C
8: HCl
View Scheme
(S)-3-(2-Ethynyl-3,4,5-trimethoxy-phenyl)-1-oxazol-2-yl-propylamine
327024-98-6

(S)-3-(2-Ethynyl-3,4,5-trimethoxy-phenyl)-1-oxazol-2-yl-propylamine

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 98 percent / DMAP; Et3N / diethyl ether / 7 h / 20 °C
2.1: 60 percent / various solvent(s) / 66 h / Heating
3.1: 99 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / 35 °C
4.1: 99 percent / aq. LiOH / tetrahydrofuran / 12 h
5.1: 45 percent Turnov. / trimethylsilyltriflate / various solvent(s) / -78 - -60 °C
6.1: 62 percent / Et3N; trimethylsilyl triflate / CH2Cl2 / 2 h / 0 °C
7.1: HCl / diethyl ether / 1 h / 20 °C
7.2: 98 percent / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h / 25 °C
View Scheme
Multi-step reaction with 8 steps
1: Et3N
2: 70 percent / 1,2-dichloro-benzene / Heating
3: LiOH
5: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C
6: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C
7: HCl
View Scheme
(1R)-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(1,3-oxazol-2-yl)propan-1-ol
206195-30-4

(1R)-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(1,3-oxazol-2-yl)propan-1-ol

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 60 percent / diphenylphosphoryl azide; triphenylphosphine; diisopropylazodicarboxylate / tetrahydrofuran / 12 h / 20 °C
2.1: 95 percent / Ph3P / tetrahydrofuran; H2O / 50 h / 20 °C
3.1: 98 percent / DMAP; Et3N / diethyl ether / 7 h / 20 °C
4.1: 60 percent / various solvent(s) / 66 h / Heating
5.1: 99 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / 35 °C
6.1: 99 percent / aq. LiOH / tetrahydrofuran / 12 h
7.1: 45 percent Turnov. / trimethylsilyltriflate / various solvent(s) / -78 - -60 °C
8.1: 62 percent / Et3N; trimethylsilyl triflate / CH2Cl2 / 2 h / 0 °C
9.1: HCl / diethyl ether / 1 h / 20 °C
9.2: 98 percent / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h / 25 °C
View Scheme
Multi-step reaction with 10 steps
1: 64 percent / PPh3; DEAD; (PhO)2P(O)N3
2: Ph3P; H2O
3: Et3N
4: 70 percent / 1,2-dichloro-benzene / Heating
5: LiOH
7: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C
8: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C
9: HCl
View Scheme
(S)-N-7-acetylamino-12,13,14-trimethoxy-5-oxatricyclo[8.4.0.02,6]tetradeca-1(10),2(6),3,11,13-pentaene
206195-21-3

(S)-N-7-acetylamino-12,13,14-trimethoxy-5-oxatricyclo[8.4.0.02,6]tetradeca-1(10),2(6),3,11,13-pentaene

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 99 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / 35 °C
2.1: 99 percent / aq. LiOH / tetrahydrofuran / 12 h
3.1: 45 percent Turnov. / trimethylsilyltriflate / various solvent(s) / -78 - -60 °C
4.1: 62 percent / Et3N; trimethylsilyl triflate / CH2Cl2 / 2 h / 0 °C
5.1: HCl / diethyl ether / 1 h / 20 °C
5.2: 98 percent / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h / 25 °C
View Scheme
Multi-step reaction with 6 steps
1: LiOH
3: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C
4: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C
5: HCl
View Scheme
(S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine
206195-23-5

(S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine

colchicine
64-86-8

colchicine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 60 percent / various solvent(s) / 66 h / Heating
2.1: 99 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / 35 °C
3.1: 99 percent / aq. LiOH / tetrahydrofuran / 12 h
4.1: 45 percent Turnov. / trimethylsilyltriflate / various solvent(s) / -78 - -60 °C
5.1: 62 percent / Et3N; trimethylsilyl triflate / CH2Cl2 / 2 h / 0 °C
6.1: HCl / diethyl ether / 1 h / 20 °C
6.2: 98 percent / 4-(dimethylamino)pyridine; Et3N / diethyl ether / 10 h / 25 °C
View Scheme
Multi-step reaction with 7 steps
1: 70 percent / 1,2-dichloro-benzene / Heating
2: LiOH
4: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C
5: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C
6: HCl
View Scheme
colchicine
64-86-8

colchicine

N-[(7S)-1,2,3-trimethoxy-9-oxo-10-amino-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
3123-89-5

N-[(7S)-1,2,3-trimethoxy-9-oxo-10-amino-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide

Conditions
ConditionsYield
With ammonium hydroxide In ethanol for 12h; Reflux;100%
With ammonium hydroxide In methanol at 20℃;90%
With ammonium hydroxide In ethanol at 110℃; for 0.25h; Microwave irradiation;75%
colchicine
64-86-8

colchicine

allocolchicinic acid
6714-14-3

allocolchicinic acid

Conditions
ConditionsYield
With sodium methylate In methanol at 65℃; for 4h;100%
With methanol; sodium methylate In water at 65℃;99%
With methanol; water; sodium methylate
Dichloromethyl methyl ether
4885-02-3

Dichloromethyl methyl ether

colchicine
64-86-8

colchicine

4-Formylcolchicine
2730-82-7

4-Formylcolchicine

Conditions
ConditionsYield
With tin(IV) chloride In dichloromethane100%
With tin(IV) chloride In dichloromethane at 20℃; for 13h; Cooling with ice; Inert atmosphere;100%
With tin(IV) chloride In dichloromethane 0 deg C, 30 min., r.t. 15 h;90%
With tin(IV) chloride In dichloromethane at 20℃;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

colchicine
64-86-8

colchicine

(S)-tert-butyl-N-acetyl(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalene-7-yl)carbamate
186374-94-7

(S)-tert-butyl-N-acetyl(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalene-7-yl)carbamate

Conditions
ConditionsYield
With dmap; triethylamine In acetonitrile at 100℃; for 7.5h;100%
With dmap; triethylamine In acetonitrile at 100℃; Inert atmosphere;98%
With dmap; triethylamine In tetrahydrofuran for 2h; Reflux;97.5%
formaldehyd
50-00-0

formaldehyd

colchicine
64-86-8

colchicine

urethane
51-79-6

urethane

ethyl {[(7S)-7-(acetylamino)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-4-yl]methyl}carbamate

ethyl {[(7S)-7-(acetylamino)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-4-yl]methyl}carbamate

Conditions
ConditionsYield
Stage #1: formaldehyd; urethane With sulfuric acid; water at 20℃; for 0.166667h;
Stage #2: colchicine at 20℃; for 4h;
99%
colchicine
64-86-8

colchicine

4-Bromocolchicine
1267993-28-1

4-Bromocolchicine

Conditions
ConditionsYield
With N-Bromosuccinimide; acetic acid99%
With N-Bromosuccinimide; acetic acid; trifluoroacetic acid at 20℃; for 1h; Schlenk technique; Inert atmosphere;95%
With N-Bromosuccinimide; acetic acid; trifluoroacetic acid In trifluoroacetic acid at 20℃; for 1h; Schlenk technique; Inert atmosphere;95%
colchicine
64-86-8

colchicine

4-Iodocolchicine
1267993-31-6

4-Iodocolchicine

Conditions
ConditionsYield
With N-iodo-succinimide; acetic acid99%
With N-iodo-succinimide; acetic acid at 70℃; for 7h; Time; Inert atmosphere;98.6%
With N-iodo-succinimide; acetic acid In acetonitrile at 70℃; for 20h; Inert atmosphere;95%
With N-iodo-succinimide; acetic acid at 70℃; for 20h; Inert atmosphere;95%
With N-iodo-succinimide; acetic acid at 70℃; for 7h;
[(S)-1-(2-aminoethyl)-pyrrolidin-2-yl]methanol
115531-70-9

[(S)-1-(2-aminoethyl)-pyrrolidin-2-yl]methanol

colchicine
64-86-8

colchicine

C28H37N3O6
1415569-02-6

C28H37N3O6

Conditions
ConditionsYield
In dichloromethane at 70℃; for 4h;99%
[(2R)-1-(2-aminoethyl)pyrrolidin-2-yl]methanol
867008-77-3

[(2R)-1-(2-aminoethyl)pyrrolidin-2-yl]methanol

colchicine
64-86-8

colchicine

C28H37N3O6
1415569-03-7

C28H37N3O6

Conditions
ConditionsYield
In dichloromethane at 70℃; for 4h;99%
colchicine
64-86-8

colchicine

Conditions
ConditionsYield
With hydrogenchloride; acetic acid In water at 100℃; for 3h;98%
With hydrogenchloride; acetic acid In water at 100℃; for 3h;98%
With hydrogenchloride; acetic acid at 100℃; for 3h;98%
colchicine
64-86-8

colchicine

ethanolamine
141-43-5

ethanolamine

N-[(S)-10-(2-hydroxy-ethylamino)-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl]-acetamide
55340-40-4

N-[(S)-10-(2-hydroxy-ethylamino)-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl]-acetamide

Conditions
ConditionsYield
In dichloromethane at 70℃; for 4h;98%
In ethanol at 20℃; for 48h;90%
8-Aminooctanoic acid
1002-57-9

8-Aminooctanoic acid

colchicine
64-86-8

colchicine

C29H38N2O7

C29H38N2O7

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water for 24h;96%
colchicine
64-86-8

colchicine

C22H25NO6*Li(1+)

C22H25NO6*Li(1+)

Conditions
ConditionsYield
With lithium nitrate In methanol at 20℃; for 24h;96%
colchicine
64-86-8

colchicine

sodium thiomethoxide
5188-07-8

sodium thiomethoxide

thiocolchicine
2730-71-4

thiocolchicine

Conditions
ConditionsYield
In water for 1h; Heating;95%
In methanol; water at 20℃; for 72h;78%
In methanol; water at 20℃; for 72h;78%
colchicine
64-86-8

colchicine

benzamidin
618-39-3

benzamidin

(S)-N-(5,6,7,8a-tetrahydro-1,2,3-trimethoxy-10-phenylbenzo[6,7]heptaleno[2,3-d]imidazol-7-yl)acetamide

(S)-N-(5,6,7,8a-tetrahydro-1,2,3-trimethoxy-10-phenylbenzo[6,7]heptaleno[2,3-d]imidazol-7-yl)acetamide

Conditions
ConditionsYield
In benzene at 20℃; for 24h; Condensation; substitution;95%
colchicine
64-86-8

colchicine

1-(2-aminoethyl)piperidin-3-ol
847499-95-0

1-(2-aminoethyl)piperidin-3-ol

C28H37N3O6
1415569-00-4

C28H37N3O6

Conditions
ConditionsYield
In dichloromethane at 70℃; for 4h;95%
colchicine
64-86-8

colchicine

ethylenediamine
107-15-3

ethylenediamine

(S)-N-(10-((2-aminoethyl)amino)-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo [a]heptalen-7-yl acetamide)
67620-27-3

(S)-N-(10-((2-aminoethyl)amino)-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo [a]heptalen-7-yl acetamide)

Conditions
ConditionsYield
In dichloromethane at 70℃; for 4h;95%
colchicine
64-86-8

colchicine

C22H25NO6*Rb(1+)*I(1-)

C22H25NO6*Rb(1+)*I(1-)

Conditions
ConditionsYield
With rubidium iodide In methanol95%
colchicine
64-86-8

colchicine

C22H25NO6*Rb(1+)*ClO4(1-)

C22H25NO6*Rb(1+)*ClO4(1-)

Conditions
ConditionsYield
With rubidium perchlorate In methanol95%
colchicine
64-86-8

colchicine

C22H25NO6*Na(1+)*NO3(1-)

C22H25NO6*Na(1+)*NO3(1-)

Conditions
ConditionsYield
With sodium nitrate In methanol at 20℃; for 24h;95%
colchicine
64-86-8

colchicine

C22H25NO6*K(1+)*NO3(1-)

C22H25NO6*K(1+)*NO3(1-)

Conditions
ConditionsYield
With potassium nitrate In methanol at 20℃; for 24h;95%
colchicine
64-86-8

colchicine

benzylamine
100-46-9

benzylamine

N-<5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-<(phenylmethyl)amino>benzoheptalen-7-yl>-(S)-acetamide
76129-15-2

N-<5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-<(phenylmethyl)amino>benzoheptalen-7-yl>-(S)-acetamide

Conditions
ConditionsYield
In ethanol at 116℃; for 20h;94%
at 20℃; for 72h;80%
With ethanol
colchicine
64-86-8

colchicine

C22H25NO6*Cs(1+)*I(1-)

C22H25NO6*Cs(1+)*I(1-)

Conditions
ConditionsYield
With cesium iodide In methanol94%
colchicine
64-86-8

colchicine

C22H25NO6*Mg(2+)*2NO3(1-)

C22H25NO6*Mg(2+)*2NO3(1-)

Conditions
ConditionsYield
With magnesium(II) nitrate In methanol at 20℃; for 24h;94%
colchicine
64-86-8

colchicine

(aR,5S)-N-(3-hydroxy-2-iodo-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cycloheptene-5-yl)-acetamide
38838-27-6

(aR,5S)-N-(3-hydroxy-2-iodo-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cycloheptene-5-yl)-acetamide

Conditions
ConditionsYield
Stage #1: colchicine With hydrogenchloride; acetic acid In water at 100℃; for 3h;
Stage #2: With iodine; potassium iodide; sodium hydroxide In water at 0 - 5℃; for 1h;
93%
Stage #1: colchicine With hydrogenchloride; acetic acid at 100℃; for 3h;
Stage #2: With iodine; potassium iodide; sodium hydroxide In water at 0 - 5℃; for 2h;
91%
Stage #1: colchicine With hydrogenchloride; acetic acid at 100℃; for 3h;
Stage #2: With iodine; potassium iodide; sodium hydroxide In water at 0 - 5℃; for 2h;
88%
colchicine
64-86-8

colchicine

C22H25NO6*Cs(1+)*ClO4(1-)

C22H25NO6*Cs(1+)*ClO4(1-)

Conditions
ConditionsYield
With cesium perchlorate In methanol93%
colchicine
64-86-8

colchicine

diethylamine
109-89-7

diethylamine

N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(diethylamino)-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
6962-03-4

N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(diethylamino)-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide

Conditions
ConditionsYield
In dichloromethane; acetonitrile for 24h; Reflux; regioselective reaction;92%
In ethanol at 20℃; for 48h;90%
In methanol at 20℃;75%
colchicine
64-86-8

colchicine

N-(10-amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide

N-(10-amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide

Conditions
ConditionsYield
With ammonium hydroxide Substitution;90%
colchicine
64-86-8

colchicine

di-n-propylamine
142-84-7

di-n-propylamine

C27H36N2O5

C27H36N2O5

Conditions
ConditionsYield
In dichloromethane; acetonitrile for 24h; Reflux; regioselective reaction;90%

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