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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Methyl 6-hydroxynicotinate Manufacturer/High quality/Best price/In stock

Cas:66171-50-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Methyl 6-hydroxynicotinate

Cas:66171-50-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

66171-50-4 METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE

Cas:66171-50-4

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 66171-50-4 with competitive price

Cas:66171-50-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

3-Pyridinecarboxylicacid, 1,6-dihydro-6-oxo-, methyl ester/ LIDE PHARMA- Factory supply / Best price

Cas:66171-50-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Pyridinecarboxylicacid, 1,6-dihydro-6-oxo-, methyl ester

Cas:66171-50-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-Pyridinecarboxylicacid, 1,6-dihydro-6-oxo-, methyl ester

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

6-Hydroxynicotinic acid methyl ester

Cas:66171-50-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

methyl 6-oxo-1,6-dihydropyridine-3-carboxylate

Cas:66171-50-4

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Methyl 6-hydroxynicotinate

Cas:66171-50-4

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Pyridinecarboxylicacid, 1,6-dihydro-6-oxo-, methyl ester

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE/High quality/Best price

Cas:66171-50-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

6-Hydroxynicotinic acid methyl ester

Cas:66171-50-4

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

6-Hydroxynicotinic acid methyl ester

Cas:66171-50-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

6-Hydroxynicotinic acid methyl ester

Cas:66171-50-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

66171-50-4 CAS NO.66171-50-4

Cas:66171-50-4

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Methyl 6-oxo-1H-pyridine-3-carboxylate

Cas:66171-50-4

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

6-Hydroxynicotinic acid methyl ester

Cas:66171-50-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

methyl 6-oxo-1,6-dihydropyridine-3-carboxylate

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Methyl 6-hydroxynicotinate cas no. 66171-50-4 98%

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

6-Hydroxynicotinic acid methyl ester

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Methyl 6-hydroxynicotinate

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Other

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer Answer: Yes, we are factory founded on 2012.Q2: How to contact with us Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours.Q3:Which kind of payment terms do you

METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3-Pyridinecarboxylicacid, 1,6-dihydro-6-oxo-, methyl ester

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

We are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for

6-Hydroxynicotinic acid methyl ester

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

6-Hydroxynicotinic acid methyl ester Application:6-Hydroxynicotinic acid methyl ester

6-Hydroxynicotinic acid methyl ester

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Other

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

66171-50-4

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Methyl 6-hydroxynicotinate cas 66171-50-4Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Methyl 6-hydroxynicotinate cas 66171-50-4

Cas:66171-50-4

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

methanol
67-56-1

methanol

6-hydroxy-3-pyridinecarboxylic acid
5006-66-6

6-hydroxy-3-pyridinecarboxylic acid

methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

Conditions
ConditionsYield
With sulfuric acid at 65 - 70℃; for 3h;99%
With sulfuric acid for 18h; Reflux;85%
With sulfuric acid In water at 20℃; for 20h; Reflux;82%
6-hydroxy-3-pyridinecarboxylic acid
5006-66-6

6-hydroxy-3-pyridinecarboxylic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

Conditions
ConditionsYield
In methanol; hexane; benzene for 2h; Ambient temperature;95%
In methanol; hexane; benzene95%
In methanol; benzene for 2h; Ambient temperature;91%
In methanol; benzene at 20℃; for 4.08333h; Product distribution / selectivity;84.9%
6-hydroxy-3-pyridinecarboxylic acid
5006-66-6

6-hydroxy-3-pyridinecarboxylic acid

A

methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

B

6-hydroxynicotinamide

6-hydroxynicotinamide

Conditions
ConditionsYield
With sulfuric acid In methanol; dichloromethaneA n/a
B 90%
methyl coumalate
6018-41-3

methyl coumalate

methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile at 20℃; for 48h; Inert atmosphere; Schlenk technique;70%
6-methoxy-nicotinic acid methyl ester
26218-80-4

6-methoxy-nicotinic acid methyl ester

methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

Conditions
ConditionsYield
With hexamethyldisilathiane; sodium methylate In various solvent(s) at 110℃; for 18h;40%
6-hydroxy-3-pyridinecarboxylic acid
5006-66-6

6-hydroxy-3-pyridinecarboxylic acid

methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

Conditions
ConditionsYield
With thionyl chloride behandeln des Produkts mit Methylalkohol;
With sulfuric acid In methanol
With hydrogenchloride In water
6-hydroxy-3-pyridinecarboxylic acid
5006-66-6

6-hydroxy-3-pyridinecarboxylic acid

oxalyl dichloride
79-37-8

oxalyl dichloride

methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

Conditions
ConditionsYield
In dichloromethane; ethyl acetate; N,N-dimethyl-formamide2.74 g (25%)
5-bromopyridin-2-ol
13466-38-1

5-bromopyridin-2-ol

methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine at 100℃; under 3750.38 Torr; for 90h; Autoclave; Large scale;24 kg
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

methyl 5-bromo-6-hydroxypyridine-3-carboxylate
381247-99-0

methyl 5-bromo-6-hydroxypyridine-3-carboxylate

Conditions
ConditionsYield
Stage #1: methyl 6-hydroxynicotinate With bromine; acetic acid at 60℃;
Stage #2: With sodium hydrogencarbonate; sodium hydroxide at 18 - 26℃; pH=~ 7;
100%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

N-(4-chloromethyl-2,3-difluoro-benzyl)-acetamide

N-(4-chloromethyl-2,3-difluoro-benzyl)-acetamide

1-[4-(acetylamino-methyl)-2,3-difluoro-benzyl]-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

1-[4-(acetylamino-methyl)-2,3-difluoro-benzyl]-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 35℃; for 3h;99%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-phenylethan-1-one
20718-17-6

2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-phenylethan-1-one

methyl 6-oxo-1-(2-oxo-2-phenylethyl)-1,6-dihydropyridine-3-carboxylate

methyl 6-oxo-1-(2-oxo-2-phenylethyl)-1,6-dihydropyridine-3-carboxylate

Conditions
ConditionsYield
With pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride In dichloromethane at 60℃; for 4h; Sealed tube; Inert atmosphere;96%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

2-(bromomethyl)pyridine hydrobromide
31106-82-8

2-(bromomethyl)pyridine hydrobromide

methyl 6-(pyridin-2-ylmethoxy)nicotinate
1126367-44-9

methyl 6-(pyridin-2-ylmethoxy)nicotinate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 18 - 25℃;95%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

ethyl iodide
75-03-6

ethyl iodide

methyl 1-ethyl-6-oxo-1,6-dihydropyridine-3-carboxylate
74925-38-5

methyl 1-ethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Conditions
ConditionsYield
In dichloromethane; acetonitrile Product distribution / selectivity;91.3%
With potassium carbonate In acetonitrile at 80℃; for 16h; Solvent; Temperature;73%
With potassium carbonate In acetonitrile at 80℃; for 16h; Solvent; Temperature;73%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

2,2-difluoro-2-(fluorosulfonyl)acetic acid
1717-59-5

2,2-difluoro-2-(fluorosulfonyl)acetic acid

methyl 6-(difluoromethoxy)nicotinate

methyl 6-(difluoromethoxy)nicotinate

Conditions
ConditionsYield
Stage #1: methyl 6-hydroxynicotinate With sodium hydride In acetonitrile at 20℃; for 0.5h;
Stage #2: 2,2-difluoro-2-(fluorosulfonyl)acetic acid In acetonitrile at 25℃; for 2h;
85.4%
Stage #1: methyl 6-hydroxynicotinate With sodium hydride In acetonitrile; mineral oil at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 2,2-difluoro-2-(fluorosulfonyl)acetic acid In acetonitrile; mineral oil at 20℃; for 0.5h; Inert atmosphere;
73%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

ethyl iodide
75-03-6

ethyl iodide

methyl 6-ethoxynicotinate
74357-22-5

methyl 6-ethoxynicotinate

Conditions
ConditionsYield
With silver carbonate In benzene at 25℃; for 96h;85%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

N-((5-(bromomethyl)pyridin-2-yl)methyl)acetamide

N-((5-(bromomethyl)pyridin-2-yl)methyl)acetamide

methyl 1-((6-(acetamidomethyl)pyridin-3-yl)methyl)-6-oxo-1,6-dihydropyridine-3-carboxylate

methyl 1-((6-(acetamidomethyl)pyridin-3-yl)methyl)-6-oxo-1,6-dihydropyridine-3-carboxylate

Conditions
ConditionsYield
With potassium carbonate In acetone Reflux;85%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

6-hydroxynicotinic acid hydrazide
134531-63-8

6-hydroxynicotinic acid hydrazide

Conditions
ConditionsYield
With hydrazine In ethanol for 1h; Heating;82%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

3-(3-phenylpropyl-2-yn-1-ylidene)-2,4-pentanedione
67082-95-5

3-(3-phenylpropyl-2-yn-1-ylidene)-2,4-pentanedione

methyl (S)-1-((4-acetyl-5-methylfuran-2-yl)(phenyl)methyl)-6-oxo-1,6-dihydropyridine-3-carboxylate

methyl (S)-1-((4-acetyl-5-methylfuran-2-yl)(phenyl)methyl)-6-oxo-1,6-dihydropyridine-3-carboxylate

Conditions
ConditionsYield
With dirhodium(II) tetrakis[N-tetrafluorophthaloyl-(S)-tert-leucinate] In diethyl ether; Cyclopentane at 0℃; for 72h; Inert atmosphere; Molecular sieve; enantioselective reaction;82%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

6-hydroxy-5-iodonicotinic acid methyl ester
885950-46-9

6-hydroxy-5-iodonicotinic acid methyl ester

Conditions
ConditionsYield
With N-iodo-succinimide In N,N-dimethyl-formamide at 70℃; for 3h;81%
With N-iodo-succinimide In N,N-dimethyl-formamide at 70℃; for 3h;81%
With N-iodo-succinimide In methanol at 50℃; for 1h;
With N-iodo-succinimide In methanol for 2h; Reflux; Large scale;53.26 kg
N,N-phenylbistrifluoromethane-sulfonimide
37595-74-7

N,N-phenylbistrifluoromethane-sulfonimide

methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

methyl 2-<(trifluoromethyl)sulfonyl>pyridine-5-carboxylate
163276-23-1

methyl 2-<(trifluoromethyl)sulfonyl>pyridine-5-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane for 48h; Ambient temperature;80%
With triethylamine In dichloromethane for 48h; Ambient temperature;68%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

2-Nitrobenzenesulfonyl chloride
1694-92-4

2-Nitrobenzenesulfonyl chloride

methyl 1-[(2-nitrophenyl)sulfonyl]-6-oxo-1,6-dihydropyridine-3-carboxylate
864812-33-9

methyl 1-[(2-nitrophenyl)sulfonyl]-6-oxo-1,6-dihydropyridine-3-carboxylate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at -78 - 40℃; for 20.75h;80%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

[1-(2-Hydroxyethyl)-1H-pyrrol-2-yl](4-methylphenyl)methanone
620621-44-5

[1-(2-Hydroxyethyl)-1H-pyrrol-2-yl](4-methylphenyl)methanone

Methyl 6-{2-[2-(4-methylbenzoyl)-1H-pyrrol-1-yl]ethoxy}nicotinate
840503-18-6

Methyl 6-{2-[2-(4-methylbenzoyl)-1H-pyrrol-1-yl]ethoxy}nicotinate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0 - 20℃; for 110h;74%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

(4-bromomethyl-2,3-difluoro-phenyl)-methanol

(4-bromomethyl-2,3-difluoro-phenyl)-methanol

1-(2,3-difluoro-4-hydroxymethyl-benzyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

1-(2,3-difluoro-4-hydroxymethyl-benzyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;70%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

methanesulfonic acid 2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethyl ester
1335213-36-9

methanesulfonic acid 2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethyl ester

6-{2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethoxy}-nicotinic acid methyl ester
1335213-37-0

6-{2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethoxy}-nicotinic acid methyl ester

Conditions
ConditionsYield
Stage #1: methyl 6-hydroxynicotinate With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: methanesulfonic acid 2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethyl ester In N,N-dimethyl-formamide at 0 - 100℃; for 12h; Sealed tube;
67%
Stage #1: methyl 6-hydroxynicotinate With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: methanesulfonic acid 2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethyl ester In N,N-dimethyl-formamide at 0 - 100℃; for 12h; Sealed tube;
67%
bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]
12354-84-6, 12354-85-7

bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]

methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

[(pentamethylcyclopentadienyl)Ir(5-methoxycarbonyl-2-pyridonate)Cl]

[(pentamethylcyclopentadienyl)Ir(5-methoxycarbonyl-2-pyridonate)Cl]

Conditions
ConditionsYield
Stage #1: methyl 6-hydroxynicotinate With sodium ethanolate In ethanol at 20℃; for 0.5h; Inert atmosphere; Schlenk technique;
Stage #2: bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] In dichloromethane at 5℃; Inert atmosphere; Schlenk technique;
56%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

N-(4-(chloromethyl)benzyl)acetamide
223512-41-2

N-(4-(chloromethyl)benzyl)acetamide

1-[4-(acetylamino-methyl)-benzyl]-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

1-[4-(acetylamino-methyl)-benzyl]-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;53%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

A

methyl 1-[(4-methylphenyl)sulfonyl]-6-oxo-1,6-dihydropyridine-3-carboxylate
325489-16-5

methyl 1-[(4-methylphenyl)sulfonyl]-6-oxo-1,6-dihydropyridine-3-carboxylate

B

methyl 6-[(4-methylphenyl)sulfonyloxy]pyridine-3-carboxylate

methyl 6-[(4-methylphenyl)sulfonyloxy]pyridine-3-carboxylate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane Reflux;A 31%
B 51%
2-iodo-propane
75-30-9

2-iodo-propane

methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

methyl 6-oxo-1-(propan-2-yl)-1,6-dihydropyridine-3-carboxylate

methyl 6-oxo-1-(propan-2-yl)-1,6-dihydropyridine-3-carboxylate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 80℃; for 16h;51%
With potassium carbonate In acetonitrile at 80℃; for 16h;51%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

1-((methoxycarbonyl)methyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester
939751-69-6

1-((methoxycarbonyl)methyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 18h;48%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

N-[2-(bromomethyl)-3-fluoro-allyl]carbamic acid tert-butyl ester

N-[2-(bromomethyl)-3-fluoro-allyl]carbamic acid tert-butyl ester

A

6-[(E)-2-[(tert-butoxycarbonylamino)methyl]-3-fluoro-propenyloxy]pyridine-3-carboxylic acid methyl ester

6-[(E)-2-[(tert-butoxycarbonylamino)methyl]-3-fluoro-propenyloxy]pyridine-3-carboxylic acid methyl ester

B

6-[(Z)-2-[(tert-butoxycarbonylamino)methyl]-3-fluoro-propenyloxy]pyridine-3-carboxylic acid methyl ester

6-[(Z)-2-[(tert-butoxycarbonylamino)methyl]-3-fluoro-propenyloxy]pyridine-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;A 48%
B 17%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((2R)-4-iodobutan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diyl diformate

(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((2R)-4-iodobutan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diyl diformate

C34H49NO7

C34H49NO7

Conditions
ConditionsYield
With silver carbonate In chloroform at 60℃; for 72h;47.9%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

methyl 2-(bromomethyl)propenoate
4224-69-5

methyl 2-(bromomethyl)propenoate

1-(2-methoxycarbonyl-allyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester
1243279-10-8

1-(2-methoxycarbonyl-allyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 18h;44%
methyl 6-hydroxynicotinate
66171-50-4

methyl 6-hydroxynicotinate

(3-phenyl-5-(trifluoromethyl)isoxazol-4-yl)methanol
1159600-63-1

(3-phenyl-5-(trifluoromethyl)isoxazol-4-yl)methanol

6-(3-phenyl-5-trifluoromethyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester
1159600-61-9

6-(3-phenyl-5-trifluoromethyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20 - 50℃; for 2h;42%

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