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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Sulbactam Manufacturer/High quality/Best price/In stock

Cas:68373-14-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Sulbactam supplier in China

Cas:68373-14-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

sulbactam manufacturer/supplier

Cas:68373-14-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Sulbactam Cas 68373-14-8 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum

High quality Sulbactam Cas 68373-14-8 with favorable price and good service

Cas:68373-14-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Sulbactam

Cas:68373-14-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Sulbactam 68373-14-8 GMP Manufacturer

Cas:68373-14-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Sulbactam (base and/or unspecified salts)

Cas:68373-14-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--68373-14-8--Sulbactam factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationshi

TIANFUCHEM--68373-14-8--Sulbactam factory price

Cas:68373-14-8

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Sulbactam CAS 68373-14-8

Cas:68373-14-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 68373-14-8 with best quality

Cas:68373-14-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Solid Storage:Store in sealed contai

best price manufacturer CAS 68373-14-8 Sulbactam

Cas:68373-14-8

Min.Order:10 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

China supplier Factory supply raw material Salbactam Acid cas 68373-14-8 with best price

Cas:68373-14-8

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, (2S,5R)- 68373-14-8

Cas:68373-14-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Pharm Raw Materials Sulbactam 99% Pure Sulbactam Powder with Best Price

Cas:68373-14-8

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Sulbactam

Cas:68373-14-8

Min.Order:1 Kilogram

FOB Price: $100.0 / 120.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Sulbactam CAS:68373-14-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Sulbactam CAS:68373-14-8

Cas:68373-14-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

SALBACTAM ACID

Cas:68373-14-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:68373-14-8

Cas:68373-14-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Maytime Bio-Tech Co.,Ltd.

We have one R&D laboratory and two product bases in Hangzhou which are established as per GMP requirements. Our technical force is rich and has a passel of technologists who have engaged in research and production of medication for ma

CAS.68373-14-8 Sulbactam

Cas:68373-14-8

Min.Order:1 Kilogram

Negotiable

Type:Other

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Sulbactam

Cas:68373-14-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 1000.0

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

CP45899 Sulbactam 68373-14-8

Cas:68373-14-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Sulbactam

Cas:68373-14-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Sulbactam

Cas:68373-14-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Sulbactam Acid

Cas:68373-14-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

Sulbactam CAS 68373-14-8

Cas:68373-14-8

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, (2S,5R)- 68373-14-8

Cas:68373-14-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

SulbactamAppearance:white powder Storage:Store in a cool dry place and keep away from strong light Package:according to customers' requirements Application:in research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or C

Sulbactam

Cas:68373-14-8

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Sulbactam

Cas:68373-14-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Salbactam Acid CAS No.:68373-14-8 Molecule Formula:C8H11NO5S Molecule Weight:233.24 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS S

Best Quality Salbactam Acid with good supplier

Cas:68373-14-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Sulbactam

Cas:68373-14-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4λ6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2-chloro-allyl ester

(2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4λ6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2-chloro-allyl ester

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium 4-methylbenzenesulfinate In tetrahydrofuran; methanol for 1h; Ambient temperature;99%
6,6-dibromopenicillanic acid-1,1-dioxide
76646-91-8

6,6-dibromopenicillanic acid-1,1-dioxide

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
With sulfuric acid; zinc In water at 12℃; for 2h; Temperature; Large scale;96%
With hydrogenchloride; magnesium In dichloromethane; water at -5 - 3℃; for 0.5h; Reagent/catalyst; Solvent; Temperature;93.1%
With tri-n-butyl-tin hydride In ethyl acetate at 20℃; for 2h; Temperature; Time; Inert atmosphere;90.9%
(2S,5R)-Benzyl 3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate 4,4-Dioxide
69388-78-9

(2S,5R)-Benzyl 3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate 4,4-Dioxide

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate for 1h; Ambient temperature;96%
Conditions
ConditionsYield
Stage #1: 6-aminopenicillanic acid With sulfuric acid; hypophosphorous acid; sodium nitrite In water; ethyl acetate at -10℃; for 1.5h;
Stage #2: With sodium tungstate (VI) dihydrate; dihydrogen peroxide In water at -5℃; for 1h; Temperature;
94.9%
sodium sulbactam
69388-84-7

sodium sulbactam

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane; water at 20℃; for 0.166667h; pH=6.9 - 7;94.8%
With hydrogenchloride In water; ethyl acetate87.2%
Multi-step reaction with 2 steps
1: 86 percent / hexamethylphosphoric acid triamide / 18 h / 55 °C
2: 99 percent / sodium p-toluenesulfinate tetrahydrate, Pd(PPh3)4 / methanol; tetrahydrofuran / 1 h / Ambient temperature
View Scheme
6,6-dibromopenicillanic acid-1,1-dioxide
76646-91-8

6,6-dibromopenicillanic acid-1,1-dioxide

nickel
7440-02-0

nickel

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
With copper In dichloromethane; water; acetic acid; acetonitrile84%
manganese
7439-96-5

manganese

6-bromo-1,1-dioxopenicillanic acid
810692-15-0

6-bromo-1,1-dioxopenicillanic acid

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
With phosphoric acid; iron In acetic acid methyl ester; water80%
sodium salt of penicillanic acid

sodium salt of penicillanic acid

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
With potassium permanganate; sodium chloride; sodium hydrogensulfite In water78%
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl penicillanate 1,1-dioxide
85871-31-4

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl penicillanate 1,1-dioxide

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; acetone at 5 - 10℃; for 4h; pH 9;65%
penicillanic acid
87-53-6

penicillanic acid

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide; potassium permanganate; sodium hydrogensulfite In water; acetic acid; ethyl acetate26%
With potassium permanganate; phosphoric acid; sodium hydroxide In water at 0 - 5℃; for 2h; pH=7.5; Temperature; pH-value;49.5 g
6,6-dibromopenicillanic acid-1,1-dioxide
76646-91-8

6,6-dibromopenicillanic acid-1,1-dioxide

A

sulbactum
68373-14-8

sulbactum

B

6β-bromopenicillanic acid 1,1-dioxide
75527-87-6

6β-bromopenicillanic acid 1,1-dioxide

C

(2S,5R,6S)-6β-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,S,S-dioxide
75527-88-7

(2S,5R,6S)-6β-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,S,S-dioxide

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal under 2250.2 - 3750.3 Torr; Product distribution; Ambient temperature; pH 7.0 - 8.0;
6,6-dibromopenicillanic acid
24158-88-1

6,6-dibromopenicillanic acid

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: KMnO4; phosphoric acid / CH2Cl2; H2O / 0.83 h / -5 °C
2: Mg; aq.HCl / ethyl acetate; H2O / 10 h / 20 °C / pH 3.5
View Scheme
Multi-step reaction with 2 steps
1: 67 percent / KMnO4, NaOH, H3PO4 / CH2Cl2; H2O / -5 °C
2: 60.4 percent / NaOH, Zn / acetonitrile; H2O / 0 - 10 °C / 1) pH 5.2 2) pH 3.5-4 (by addition of 4M HCl), 30 min
View Scheme
Multi-step reaction with 3 steps
1: Sodium orthovanadate; dihydrogen peroxide / dichloromethane; water / 2.5 h / 5 - 10 °C
2: potassium permanganate; ammonium acetate / dichloromethane; water / 2 h / 5 - 15 °C
3: magnesium; sulfuric acid / water; ethyl acetate / 1.75 h / 0 - 5 °C / pH 3.8 - 4
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide; water; potassium permanganate; phosphoric acid / 0 - 5 °C
2: zinc / water / 1.5 h / 0 °C / pH Ca. 3.5
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide / water; ethyl acetate / 0.5 h / 5 °C / pH 7
1.2: 0.5 h / -5 °C
1.3: pH 1.23
2.1: hydrogenchloride; magnesium / water; ethyl acetate / 0.67 h / 0 °C / pH 3.5 - 4
View Scheme
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 6-diazopenicillanate
115923-36-9

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 6-diazopenicillanate

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 85 percent / bromine / CH2Cl2 / 1 h / 0 - 5 °C
2: 72 percent / hydrogen, K2HPO4 / 5percent palladium on calcium carbonate / ethyl acetate; H2O / 2 h / 2068.6 Torr / Ambient temperature
3: 75 percent / 30percent hydrogen peroxide, sodium tungstate / acetone / 48 h / Ambient temperature
4: 65 percent / NaHCO3 / acetone; H2O / 4 h / 5 - 10 °C / pH 9
View Scheme
Multi-step reaction with 4 steps
1: 85 percent / bromine / CH2Cl2 / 1 h / 0 - 5 °C
2: 83.7 percent / m-chloroperbenzoic acid / CH2Cl2 / Ambient temperature
3: 80 percent / hydrogen, K2HPO4 / palladium on charcoal / ethyl acetate; H2O / 1 h / 2585.7 Torr / Ambient temperature
4: 65 percent / NaHCO3 / acetone; H2O / 4 h / 5 - 10 °C / pH 9
View Scheme
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl penicillanate
85871-33-6

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl penicillanate

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75 percent / 30percent hydrogen peroxide, sodium tungstate / acetone / 48 h / Ambient temperature
2: 65 percent / NaHCO3 / acetone; H2O / 4 h / 5 - 10 °C / pH 9
View Scheme
6-aminopenicillanic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
80715-30-6

6-aminopenicillanic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 85 percent / sodium nitrile, 5percent aq. H2SO4 / H2O; CH2Cl2 / 1 h / 0 - 5 °C
2: 85 percent / bromine / CH2Cl2 / 1 h / 0 - 5 °C
3: 72 percent / hydrogen, K2HPO4 / 5percent palladium on calcium carbonate / ethyl acetate; H2O / 2 h / 2068.6 Torr / Ambient temperature
4: 75 percent / 30percent hydrogen peroxide, sodium tungstate / acetone / 48 h / Ambient temperature
5: 65 percent / NaHCO3 / acetone; H2O / 4 h / 5 - 10 °C / pH 9
View Scheme
Multi-step reaction with 5 steps
1: 85 percent / sodium nitrile, 5percent aq. H2SO4 / H2O; CH2Cl2 / 1 h / 0 - 5 °C
2: 85 percent / bromine / CH2Cl2 / 1 h / 0 - 5 °C
3: 83.7 percent / m-chloroperbenzoic acid / CH2Cl2 / Ambient temperature
4: 80 percent / hydrogen, K2HPO4 / palladium on charcoal / ethyl acetate; H2O / 1 h / 2585.7 Torr / Ambient temperature
5: 65 percent / NaHCO3 / acetone; H2O / 4 h / 5 - 10 °C / pH 9
View Scheme
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 6,6-dibromopenicillanate
103453-04-9

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 6,6-dibromopenicillanate

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 72 percent / hydrogen, K2HPO4 / 5percent palladium on calcium carbonate / ethyl acetate; H2O / 2 h / 2068.6 Torr / Ambient temperature
2: 75 percent / 30percent hydrogen peroxide, sodium tungstate / acetone / 48 h / Ambient temperature
3: 65 percent / NaHCO3 / acetone; H2O / 4 h / 5 - 10 °C / pH 9
View Scheme
Multi-step reaction with 3 steps
1: 83.7 percent / m-chloroperbenzoic acid / CH2Cl2 / Ambient temperature
2: 80 percent / hydrogen, K2HPO4 / palladium on charcoal / ethyl acetate; H2O / 1 h / 2585.7 Torr / Ambient temperature
3: 65 percent / NaHCO3 / acetone; H2O / 4 h / 5 - 10 °C / pH 9
View Scheme
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 6,6-dibromopenicillanate 1,1-dioxide
103453-09-4

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 6,6-dibromopenicillanate 1,1-dioxide

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / hydrogen, K2HPO4 / palladium on charcoal / ethyl acetate; H2O / 1 h / 2585.7 Torr / Ambient temperature
2: 65 percent / NaHCO3 / acetone; H2O / 4 h / 5 - 10 °C / pH 9
View Scheme
(3S,4R)-4-<(2-Methyl-3-buten-2-yl)thio>-3-(trimethylsilyl)-2-azetidinone
128971-79-9

(3S,4R)-4-<(2-Methyl-3-buten-2-yl)thio>-3-(trimethylsilyl)-2-azetidinone

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 83 percent / i-Pr2NEt, N,N-(dimethylamino)pyridine / CH2Cl2 / 3 h / Ambient temperature
2: 1) O3, 2) Me2S / 1) CH2Cl2, -78 deg C, 2) 0 deg C, 15 min
3: 1) t-BuOK / 1) THF, t-BuOH, 0 deg C, 15 min, 2) 0 deg C, 40 h
4: 72 percent / Et3N, acetyl chloride / 20 h / 0 °C
5: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C, 2 min
6: 91 percent / DBU / CH2Cl2 / 8 h
7: 93 percent / oxone, NaHCO3 / H2O; methanol / 18 h / Ambient temperature; pH 3
8: 96 percent / H2 / Pd/C / ethyl acetate / 1 h / Ambient temperature
View Scheme
(3S,4R)-1-(tert-Butyldimethylsilyl)-4-<(2-methyl-3-buten-2-yl)thio>-3-(trimethylsilyl)-2-azetidinone
128971-80-2

(3S,4R)-1-(tert-Butyldimethylsilyl)-4-<(2-methyl-3-buten-2-yl)thio>-3-(trimethylsilyl)-2-azetidinone

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1) O3, 2) Me2S / 1) CH2Cl2, -78 deg C, 2) 0 deg C, 15 min
2: 1) t-BuOK / 1) THF, t-BuOH, 0 deg C, 15 min, 2) 0 deg C, 40 h
3: 72 percent / Et3N, acetyl chloride / 20 h / 0 °C
4: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C, 2 min
5: 91 percent / DBU / CH2Cl2 / 8 h
6: 93 percent / oxone, NaHCO3 / H2O; methanol / 18 h / Ambient temperature; pH 3
7: 96 percent / H2 / Pd/C / ethyl acetate / 1 h / Ambient temperature
View Scheme
(3S,4R)-1-(tert-Butyldimethylsilyl)-4-<(2-methyl-3-oxo-2-propyl)thio>-3-(trimethylsilyl)-2-azetidinone
124831-31-8

(3S,4R)-1-(tert-Butyldimethylsilyl)-4-<(2-methyl-3-oxo-2-propyl)thio>-3-(trimethylsilyl)-2-azetidinone

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1) t-BuOK / 1) THF, t-BuOH, 0 deg C, 15 min, 2) 0 deg C, 40 h
2: 72 percent / Et3N, acetyl chloride / 20 h / 0 °C
3: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C, 2 min
4: 91 percent / DBU / CH2Cl2 / 8 h
5: 93 percent / oxone, NaHCO3 / H2O; methanol / 18 h / Ambient temperature; pH 3
6: 96 percent / H2 / Pd/C / ethyl acetate / 1 h / Ambient temperature
View Scheme
(3S,4R)-4-<<4-(Benzyloxy)-3-hydroxy-2-methyl-4-nitro-2-butyl>thio>-1-(tert-butyldimethylsilyl)-3-(trimethylsilyl)-2-azetidinone
128971-81-3

(3S,4R)-4-<<4-(Benzyloxy)-3-hydroxy-2-methyl-4-nitro-2-butyl>thio>-1-(tert-butyldimethylsilyl)-3-(trimethylsilyl)-2-azetidinone

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 72 percent / Et3N, acetyl chloride / 20 h / 0 °C
2: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C, 2 min
3: 91 percent / DBU / CH2Cl2 / 8 h
4: 93 percent / oxone, NaHCO3 / H2O; methanol / 18 h / Ambient temperature; pH 3
5: 96 percent / H2 / Pd/C / ethyl acetate / 1 h / Ambient temperature
View Scheme
(3S,4R)-4-<<4-(Benzyloxy)-2-methyl-4-nitro-3(Z)-buten-2-yl>thio>-1-(tert-butyldimethylsilyl)-3-(trimethylsilyl)-2-azetidinone
124831-32-9

(3S,4R)-4-<<4-(Benzyloxy)-2-methyl-4-nitro-3(Z)-buten-2-yl>thio>-1-(tert-butyldimethylsilyl)-3-(trimethylsilyl)-2-azetidinone

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C, 2 min
2: 91 percent / DBU / CH2Cl2 / 8 h
3: 93 percent / oxone, NaHCO3 / H2O; methanol / 18 h / Ambient temperature; pH 3
4: 96 percent / H2 / Pd/C / ethyl acetate / 1 h / Ambient temperature
View Scheme
(2R,5R)-Benzyl 3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
124831-33-0

(2R,5R)-Benzyl 3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 91 percent / DBU / CH2Cl2 / 8 h
2: 93 percent / oxone, NaHCO3 / H2O; methanol / 18 h / Ambient temperature; pH 3
3: 96 percent / H2 / Pd/C / ethyl acetate / 1 h / Ambient temperature
View Scheme
(2S,5R)-Benzyl 3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
62263-72-3

(2S,5R)-Benzyl 3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / oxone, NaHCO3 / H2O; methanol / 18 h / Ambient temperature; pH 3
2: 96 percent / H2 / Pd/C / ethyl acetate / 1 h / Ambient temperature
View Scheme
6-chloro-6-iodopenicillanic acid 1,1-dioxide
76517-16-3

6-chloro-6-iodopenicillanic acid 1,1-dioxide

tri-n-butyl-tin hydride
688-73-3

tri-n-butyl-tin hydride

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
With chloro-trimethyl-silane; sodium hydrogencarbonate; triethylamine; 2,2'-azobis(isobutyronitrile) In ethyl acetate; benzene
6-bromo-6-iodopenicillanic acid 1,1-dioxide
76517-25-4

6-bromo-6-iodopenicillanic acid 1,1-dioxide

tri-n-butyl-tin hydride
688-73-3

tri-n-butyl-tin hydride

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
With chloro-trimethyl-silane; sodium hydrogencarbonate; triethylamine; 2,2'-azobis(isobutyronitrile) In hexane; ethyl acetate; benzene
6,6-dibromopenicillanic acid-1,1-dioxide
76646-91-8

6,6-dibromopenicillanic acid-1,1-dioxide

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
palladium In ethyl acetate
palladium In ethyl acetate
magnesium dihydride
7439-95-4

magnesium dihydride

2,6 dichloroacetophenone
2040-05-3

2,6 dichloroacetophenone

6,6-dibromopenicillanic acid-1,1-dioxide
76646-91-8

6,6-dibromopenicillanic acid-1,1-dioxide

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
With hydrogenchloride In hexane; water; ethyl acetate; acetone
6-bromo-1,1-dioxopenicillanic acid
810692-15-0

6-bromo-1,1-dioxopenicillanic acid

sulbactum
68373-14-8

sulbactum

Conditions
ConditionsYield
In acetic acid methyl ester; water
sulbactum
68373-14-8

sulbactum

sodium sulbactam
69388-84-7

sodium sulbactam

Conditions
ConditionsYield
With sodium isooctanoate In ethyl acetate99.3%
With sodium 2-ethylhexanoic acid In water; isopropyl alcohol at 20 - 35℃; for 2.33333h;95%
With sodium acetate; sodium hydrogencarbonate at 20 - 25℃; pH=5.5 - 6;
With sodium isooctanoate In methanol; water at 25℃; pH=4.5; Reagent/catalyst; Solvent; Temperature; pH-value;542g
chlorobromomethane
74-97-5

chlorobromomethane

sulbactum
68373-14-8

sulbactum

chloromethyl penicillanate 1,1-dioxide
76247-40-0

chloromethyl penicillanate 1,1-dioxide

Conditions
ConditionsYield
With pyridine at 20℃; for 3.5h; Darkness;92.6%
1-bromomethyl-4-iodobenzene
16004-15-2

1-bromomethyl-4-iodobenzene

sulbactum
68373-14-8

sulbactum

4-iodobenzyl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept ane-2-carboxylate 4,4-dioxide

4-iodobenzyl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept ane-2-carboxylate 4,4-dioxide

Conditions
ConditionsYield
With potassium carbonate; potassium iodide at 20℃; for 12h;92%
1,4-Diiodobutane
628-21-7

1,4-Diiodobutane

sulbactum
68373-14-8

sulbactum

C12H18INO5S

C12H18INO5S

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 12h; Inert atmosphere;86%
chlorosulfuric acid chloromethyl ester
49715-04-0

chlorosulfuric acid chloromethyl ester

sulbactum
68373-14-8

sulbactum

chloromethyl penicillanate 1,1-dioxide
76247-40-0

chloromethyl penicillanate 1,1-dioxide

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane 1.) 20-22 deg C, 2.) 30 min;80%
4-Methyl-1-pentanol
626-89-1

4-Methyl-1-pentanol

sulbactum
68373-14-8

sulbactum

4-methylpentyl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide

4-methylpentyl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide

Conditions
ConditionsYield
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 16h;78%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;74%
methyl chlorosulfate
812-01-1

methyl chlorosulfate

sulbactum
68373-14-8

sulbactum

2S,5R-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo<2.2.0>-heptane-2 carboxylic acid methyl ester 4,4-dioxide
65039-72-7

2S,5R-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo<2.2.0>-heptane-2 carboxylic acid methyl ester 4,4-dioxide

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane 1.) 20-22 deg C, 2.) 30 min;75%
sulbactum
68373-14-8

sulbactum

methyl iodide
74-88-4

methyl iodide

2S,5R-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo<2.2.0>-heptane-2 carboxylic acid methyl ester 4,4-dioxide
65039-72-7

2S,5R-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo<2.2.0>-heptane-2 carboxylic acid methyl ester 4,4-dioxide

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 20℃; for 16h;75%
sulbactum
68373-14-8

sulbactum

[(chlorosulfonyl)oxy]methyl sulfurochloridate
92975-18-3

[(chlorosulfonyl)oxy]methyl sulfurochloridate

C17H22N2O10S2
81156-60-7

C17H22N2O10S2

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane 1.) 20-22 deg C, 2.) 30 min;73%
1-(1-bromoethyl)-4-bromomethyl-benzene

1-(1-bromoethyl)-4-bromomethyl-benzene

sulbactum
68373-14-8

sulbactum

C17H20BrNO5S

C17H20BrNO5S

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 3h;70%
Benzophenone oxime
574-66-3

Benzophenone oxime

sulbactum
68373-14-8

sulbactum

(2S,5R)-2-((((diphenylmethylene)amino)oxy)carbonyl)-3,3-dimethyl-4-thia-1-azabicyclo[3.2.0]heptan-7-one 4,4-dioxide

(2S,5R)-2-((((diphenylmethylene)amino)oxy)carbonyl)-3,3-dimethyl-4-thia-1-azabicyclo[3.2.0]heptan-7-one 4,4-dioxide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Schlenk technique; Inert atmosphere;67%
4,5-di(bromomethyl)-2-oxo-1,3-dioxole
62458-19-9

4,5-di(bromomethyl)-2-oxo-1,3-dioxole

sulbactum
68373-14-8

sulbactum

(5-bromomethyl-2-oxo-1,3-dioxol-4-yl)methyl penicillanate 1,1-dioxide
115946-67-3

(5-bromomethyl-2-oxo-1,3-dioxol-4-yl)methyl penicillanate 1,1-dioxide

Conditions
ConditionsYield
With potassium hydrogencarbonate; sodium iodide In ethyl acetate; N,N-dimethyl-formamide for 8h; Ambient temperature;61.5%
sulbactum
68373-14-8

sulbactum

3-bromo-N-(triphenylmethyl)propanamine
88811-16-9

3-bromo-N-(triphenylmethyl)propanamine

C30H32N2O5S

C30H32N2O5S

Conditions
ConditionsYield
Stage #1: sulbactum With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: 3-bromo-N-(triphenylmethyl)propanamine In N,N-dimethyl-formamide at 20℃; for 16h;
52%
sulbactum
68373-14-8

sulbactum

α-chloroethyl chlorosulfate
90906-61-9

α-chloroethyl chlorosulfate

1-chloroethyl penicillanate 1,1-dioxide
76350-32-8

1-chloroethyl penicillanate 1,1-dioxide

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane 1.) 20-22 deg C, 2.) 30 min;47%
potassium bicarbonate

potassium bicarbonate

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

sulbactum
68373-14-8

sulbactum

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl penicillanate 1,1-dioxide
85871-31-4

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl penicillanate 1,1-dioxide

Conditions
ConditionsYield
With sodium chloride In N-methyl-acetamide; water; ethyl acetate47%
sulbactum
68373-14-8

sulbactum

2-nitrophenylmethyl bromide
3958-60-9

2-nitrophenylmethyl bromide

2-nitrobenzyl 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate 4,4-dioxide

2-nitrobenzyl 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate 4,4-dioxide

Conditions
ConditionsYield
Stage #1: sulbactum With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: 2-nitrophenylmethyl bromide In N,N-dimethyl-formamide at 20℃; for 16h;
46%
sulbactum
68373-14-8

sulbactum

3,4-dichlorobenzyl bromide
18880-04-1

3,4-dichlorobenzyl bromide

3,4-dichlorobenzyl 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate 4,4- dioxide

3,4-dichlorobenzyl 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate 4,4- dioxide

Conditions
ConditionsYield
Stage #1: sulbactum With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: 3,4-dichlorobenzyl bromide In N,N-dimethyl-formamide at 20℃; for 16h;
45%
diphenylmethylpiperazine
841-77-0

diphenylmethylpiperazine

sulbactum
68373-14-8

sulbactum

(2S)-3,3-dimethyl-2-(4'-benzhydrylpiperazine-1'-carbonyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane 4,4-dioxide

(2S)-3,3-dimethyl-2-(4'-benzhydrylpiperazine-1'-carbonyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane 4,4-dioxide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide at 20℃;40%
4-ethylbenzyl alcohol
768-59-2

4-ethylbenzyl alcohol

sulbactum
68373-14-8

sulbactum

4-ethylbenzyl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide

4-ethylbenzyl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide

Conditions
ConditionsYield
Stage #1: sulbactum With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.0833333h; Inert atmosphere;
Stage #2: 4-ethylbenzyl alcohol In dichloromethane at 0 - 20℃; for 48h; Inert atmosphere;
27%

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