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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-b-D-ribofuranosyl-

Cas:69-33-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Tubercidine Cas 69-33-0 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum

Factory supply Tubercidine Cas 69-33-0 with high quality and best price

Cas:69-33-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

69-33-0 TUBERCIDIN

Cas:69-33-0

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 69-33-0 with best quality

Cas:69-33-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

TUBERCIDIN CAS69-33-0

Cas:69-33-0

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-b-D-ribofuranosyl- 69-33-0

Cas:69-33-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-b-D-ribofuranosyl-/ LIDE PHARMA- Factory supply / Best price

Cas:69-33-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

TUBERCIDIN CAS:69-33-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

TUBERCIDIN CAS:69-33-0

Cas:69-33-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-b-D-ribofuranosyl-

Cas:69-33-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-b-D-ribofuranosyl-

Cas:69-33-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

TUBERCIDIN

Cas:69-33-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

TUBERCIDIN

Cas:69-33-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

7-Deazaadenosine

Cas:69-33-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-b-D-ribofuranosyl-

Cas:69-33-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

TUBERCIDIN

Cas:69-33-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products tubercidin

Cas:69-33-0

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Tubercidin; 7-Deazaadenosine; Sparsomycin A

Cas:69-33-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

YUNBIO TECH CO.,LTD

Tubercidin with CAS# 69-33-0/ nucleoside/ worldwide Top Pharma factory vendor with most competitive price 1.High quality 2. Free sample available 3. Competitive price 4.Experienced service team 5.Fast delivery 6.Considerate after-sale service Ou

Tubercidin with CAS# 69-33-0/ nucleoside/ worldwide Top Pharma factory vendor with most competitive price

Cas:69-33-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

TUBERCIDIN; TUBERCIDINE; 3-d) pyrimidin-4-amine, 7-beta-d-ribofuranosyl-7h-pyrrolo(;3-d)pyrimidine,4-amino-7-beta-d-ribofuranosyl-7h-pyrrolo(; 4-amino-7-(beta-d-ribofuranosyl)-pyrrolo(2,3-d)pyrimidine;4-amino-7-beta-d-ribofuranosyl-7h-pyrrolo(2,3-d

TUBERCIDIN

Cas:69-33-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Tubercidine

Cas:69-33-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

7-Deaza-adeonsine

Cas:69-33-0

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/Tubercidin

Cas:69-33-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

tubercidin cas no. 69-33-0 98%

Cas:69-33-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Tubercidin

Cas:69-33-0

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

69-33-0

Cas:69-33-0

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 7-Deazaadenosine 50mg

Cas:69-33-0

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-b-D-ribofuranosyl-

Cas:69-33-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-b-D-ribofuranosyl-

Cas:69-33-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Tubercidine CAS No.69-33-0

Cas:69-33-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-b-D-ribofuranosyl- cas 69-33-0Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Synthetic route

(2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diyl dibenzoate
29914-75-8

(2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diyl dibenzoate

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
With ammonia In methanol at 130℃; for 16h;85%
4-chloro-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine
16754-80-6

4-chloro-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
With ammonia In methanol at 50℃; for 24h;82%
With ammonia In methanol at 120℃; for 15h;81%
With ammonia In methanol at 120 - 130℃; steel bomb, overnight;81%
With ammonia In methanol at 120℃; Sealed tube;60.6%
With ammonia In methanol at 110℃; for 16h;
4-(methylsulfonyl)-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine
120401-34-5

4-(methylsulfonyl)-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
With ammonia In methanol at 50℃; for 12h;75%
4-Amino-2-(methylthio)-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin
94773-30-5

4-Amino-2-(methylthio)-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
nickel In N,N-dimethyl acetamide for 4h; Heating;67%
5-Bromotubercidin
21193-80-6

5-Bromotubercidin

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
With palladium on activated charcoal; ammonium formate In ethanol for 3h; Reflux;65%
5-iodotubercidin
24386-93-4

5-iodotubercidin

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
With palladium on activated charcoal; ammonium formate In ethanol for 5h; Reflux;45%
With palladium on activated charcoal; hydrogen; triethylamine In N,N-dimethyl-formamide for 18h;
7-[3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
85335-76-8

7-[3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

A

tubercidin
69-33-0

tubercidin

B

2'-O-methylthiomethyltubercidin
90813-69-7

2'-O-methylthiomethyltubercidin

C

4-amino-7-(β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine
64526-34-7

4-amino-7-(β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine

Conditions
ConditionsYield
With sodium tetrahydroborate; acetic anhydride 1.) DMSO, r.t., 27 h; 2.) EtOH, cooling to 0 deg C, 1 h;A 12%
B 7%
C n/a
2,3-O-isopropylidene-5-O-(tert-butyldimethylsilyl)-α-D-ribofuranosyl chloride
102690-94-8

2,3-O-isopropylidene-5-O-(tert-butyldimethylsilyl)-α-D-ribofuranosyl chloride

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 65 percent / KOH / tris<2-(2-methoxyethoxy)ethyl>amine / tetrahydrofuran
2: 68 percent / 10percent aq.CF3COOH
3: 81 percent / 80percent 3-chloroperbenzoic acid / methanol / 2 h / Ambient temperature
4: 75 percent / NH3 / methanol / 12 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: 65 percent / KOH / tris<2-(2-methoxyethoxy)ethyl>amine / acetonitrile; tetrahydrofuran / 20 h
2: 89 percent / 90percent aq.CF3COOH / 1 h / Ambient temperature
3: 82 percent / NH3 / methanol / 24 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: 1) sodium hydride (60percent in oil) / 1) acetonitrile, 0.5 h; 2) THF, RT, overnight
2: 99 percent / trifluoroacetic acid / H2O / 1 h / Ambient temperature
3: 81 percent / NH3 / methanol / 120 - 130 °C / steel bomb, overnight
View Scheme
Multi-step reaction with 3 steps
1: 67 percent / sodium hydride / acetonitrile / 1 h / Ambient temperature
2: 98.5 percent / aq. trifluoroacetic acid / 1 h / Ambient temperature
3: 81 percent / ammonia / methanol / 15 h / 120 °C
View Scheme
4-chloro-7-<5-O-<(1,1-dimethylethyl)dimethylsilyl>-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine
115479-39-5

4-chloro-7-<5-O-<(1,1-dimethylethyl)dimethylsilyl>-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / 90percent aq.CF3COOH / 1 h / Ambient temperature
2: 82 percent / NH3 / methanol / 24 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: 99 percent / trifluoroacetic acid / H2O / 1 h / Ambient temperature
2: 81 percent / NH3 / methanol / 120 - 130 °C / steel bomb, overnight
View Scheme
Multi-step reaction with 2 steps
1: 98.5 percent / aq. trifluoroacetic acid / 1 h / Ambient temperature
2: 81 percent / ammonia / methanol / 15 h / 120 °C
View Scheme
5-O-<(1,1-dimethylethyl)dimethylsilyl>-2,3-O-(1-methylethylidene)-β-D-ribofuranose
75921-20-9

5-O-<(1,1-dimethylethyl)dimethylsilyl>-2,3-O-(1-methylethylidene)-β-D-ribofuranose

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: CCl4, tris(dimethylamino)phosphane / tetrahydrofuran / 2 h / -78 °C
2: 65 percent / KOH / tris<2-(2-methoxyethoxy)ethyl>amine / tetrahydrofuran
3: 68 percent / 10percent aq.CF3COOH
4: 81 percent / 80percent 3-chloroperbenzoic acid / methanol / 2 h / Ambient temperature
5: 75 percent / NH3 / methanol / 12 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1: CCl4, tris(dimethylamino)phosphane / tetrahydrofuran / 2 h / -78 °C
2: 65 percent / KOH / tris<2-(2-methoxyethoxy)ethyl>amine / acetonitrile; tetrahydrofuran / 20 h
3: 89 percent / 90percent aq.CF3COOH / 1 h / Ambient temperature
4: 82 percent / NH3 / methanol / 24 h / 50 °C
View Scheme
7-<5-O-<(1,1-dimethylethyl)dimethylsilyl>-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl>-4-(methylthio)-7H-pyrrolo<2,3-d>pyrimidine
120401-29-8

7-<5-O-<(1,1-dimethylethyl)dimethylsilyl>-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl>-4-(methylthio)-7H-pyrrolo<2,3-d>pyrimidine

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 68 percent / 10percent aq.CF3COOH
2: 81 percent / 80percent 3-chloroperbenzoic acid / methanol / 2 h / Ambient temperature
3: 75 percent / NH3 / methanol / 12 h / 50 °C
View Scheme
4-(methylthio)-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine
16754-86-2

4-(methylthio)-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 81 percent / 80percent 3-chloroperbenzoic acid / methanol / 2 h / Ambient temperature
2: 75 percent / NH3 / methanol / 12 h / 50 °C
View Scheme
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1) sodium hydride (60percent in oil) / 1) acetonitrile, 0.5 h; 2) THF, RT, overnight
2: 99 percent / trifluoroacetic acid / H2O / 1 h / Ambient temperature
3: 81 percent / NH3 / methanol / 120 - 130 °C / steel bomb, overnight
View Scheme
Multi-step reaction with 3 steps
1: 67 percent / sodium hydride / acetonitrile / 1 h / Ambient temperature
2: 98.5 percent / aq. trifluoroacetic acid / 1 h / Ambient temperature
3: 81 percent / ammonia / methanol / 15 h / 120 °C
View Scheme
4-chloro-2-(methylthio)-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine
85572-94-7

4-chloro-2-(methylthio)-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 74 percent / conc. aq. NH3 / methanol / 20 h / 120 °C
2: 67 percent / Raney-Ni / N,N-dimethyl-acetamide / 4 h / Heating
View Scheme
2,3-O-isopropylidene-5-O-(tertbutyldimethyl)-α-D-ribofuranosyl chloride

2,3-O-isopropylidene-5-O-(tertbutyldimethyl)-α-D-ribofuranosyl chloride

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / acetonitrile; mineral oil / 0.5 h / 20 °C / Inert atmosphere
1.2: 40 h / 20 °C
2.1: trifluoroacetic acid / water / 1 h / 0 - 20 °C
3.1: ammonia / methanol / 120 °C / Sealed tube
View Scheme
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / acetonitrile; mineral oil / 0.5 h / 20 °C / Inert atmosphere
1.2: 40 h / 20 °C
2.1: trifluoroacetic acid / water / 1 h / 0 - 20 °C
3.1: ammonia / methanol / 120 °C / Sealed tube
View Scheme
4-chloro-2,3-O-isopropylidene-5-O-(tertbutyldimethylsilyl)-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

4-chloro-2,3-O-isopropylidene-5-O-(tertbutyldimethylsilyl)-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

tubercidin
69-33-0

tubercidin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trifluoroacetic acid / water / 1 h / 0 - 20 °C
2: ammonia / methanol / 120 °C / Sealed tube
View Scheme
tubercidin
69-33-0

tubercidin

4-amino-7-(2,3-anhydro-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine
40627-31-4

4-amino-7-(2,3-anhydro-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Stage #1: tubercidin With 2-acetoxy-2-methylpropanoyl chloride In water; acetonitrile at 20℃; for 0.75h;
Stage #2: With Dowex 1 x 2 (OH-) In methanol at 20℃; for 2h; Further stages.;
100%
With Dowex 1 x 2 (OH(-)); acetoxyisobutyryl bromide; water 1.) MeCN, 19-22 deg C, 1 h, 2.) MeOH, 1 h; Yield given. Multistep reaction;
tubercidin
69-33-0

tubercidin

(2R,3R,4S,5R)-2-(4-Amino-3-oxy-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol

(2R,3R,4S,5R)-2-(4-Amino-3-oxy-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In methanol Ambient temperature;97%
tubercidin
69-33-0

tubercidin

7-β-D-ribofuranosylpyrrolo<2,3-d>pyrimidin-4-one
2862-16-0

7-β-D-ribofuranosylpyrrolo<2,3-d>pyrimidin-4-one

Conditions
ConditionsYield
With acetic acid; sodium nitrite at 60℃; for 12h;96%
N,N'-bis(dimethylaminomethylene)hydrazine
16114-05-9

N,N'-bis(dimethylaminomethylene)hydrazine

tubercidin
69-33-0

tubercidin

7-(β-D-ribofuranosyl)-4-(1,2,4-triazol-4-yl)pyrrolo<2,3-d>pyrimidine
163632-56-2

7-(β-D-ribofuranosyl)-4-(1,2,4-triazol-4-yl)pyrrolo<2,3-d>pyrimidine

Conditions
ConditionsYield
With pyridine at 100℃; for 24h;95%
2-chloroethanal
107-20-0

2-chloroethanal

tubercidin
69-33-0

tubercidin

N1-deazaethenoadenosine
53437-77-7

N1-deazaethenoadenosine

Conditions
ConditionsYield
In DMF (N,N-dimethyl-formamide) at 50℃; for 20h;94%
tubercidin
69-33-0

tubercidin

acetic anhydride
108-24-7

acetic anhydride

4-acetylamino-7-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

4-acetylamino-7-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
With pyridine at 50℃; for 2h;91%
Stage #1: tubercidin; acetic anhydride With pyridine at 20 - 60℃;
Stage #2: With 1H-imidazole In ethanol at 20℃; for 8h;
85%
tubercidin
69-33-0

tubercidin

acetic anhydride
108-24-7

acetic anhydride

2',3',5'-tri-O-acetyltubercidin
60343-84-2

2',3',5'-tri-O-acetyltubercidin

Conditions
ConditionsYield
With pyridine at 20℃; for 1h;89%
With pyridine 1.) 0 deg C, 1 h, 2.) 25 deg C, 5 h;86%
With pyridine at 0 - 20℃; for 21h; Inert atmosphere;86%
tubercidin
69-33-0

tubercidin

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

((3aR,4R,6R,6aR)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol
16739-75-6

((3aR,4R,6R,6aR)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

Conditions
ConditionsYield
With camphor-10-sulfonic acid In water; acetone at 20℃; for 16h; Inert atmosphere;88%
With toluene-4-sulfonic acid In acetone for 2h; Reflux;47%
With toluene-4-sulfonic acid
tubercidin
69-33-0

tubercidin

N,N-dimethylformamide diethyl diacetal
1188-33-6

N,N-dimethylformamide diethyl diacetal

4-<<(dimethylamino)methylidene>amino>-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine
57881-19-3

4-<<(dimethylamino)methylidene>amino>-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 50℃; for 1h;85%
tubercidin
69-33-0

tubercidin

(2R,3R,4S,5S)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(chloromethyl)tetrahydrofuran-3,4-diol
53458-85-8

(2R,3R,4S,5S)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(chloromethyl)tetrahydrofuran-3,4-diol

Conditions
ConditionsYield
Stage #1: tubercidin With pyridine In acetonitrile at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: With thionyl chloride In acetonitrile at 0 - 20℃;
Stage #3: With ammonium hydroxide In methanol for 0.5h;
85%
tubercidin
69-33-0

tubercidin

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

2',3',5'-Tri-O-(tert-butyldimethylsilyl)tubercidin
87119-54-8

2',3',5'-Tri-O-(tert-butyldimethylsilyl)tubercidin

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide for 18h; Ambient temperature;71%
di(rhodium)tetracarbonyl dichloride

di(rhodium)tetracarbonyl dichloride

tubercidin
69-33-0

tubercidin

dicarbonylchloro(7-desazaadenosin)rhodium(I)

dicarbonylchloro(7-desazaadenosin)rhodium(I)

Conditions
ConditionsYield
In methanol under N2 to (Rh(CO)2Cl)2 in CH3OH was added tubercidine and at 20°C for 2 h stirred; solvent evapd. in high vac., to the remained oil ether added; it formed solid material; filtrated, washed with ether. dried; elem. anal.;70%
tubercidin
69-33-0

tubercidin

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2'-O-tosyltubercidin

2'-O-tosyltubercidin

Conditions
ConditionsYield
Stage #1: tubercidin With di(n-butyl)tin oxide In methanol for 0.75h; Heating;
Stage #2: p-toluenesulfonyl chloride With triethylamine In methanol for 0.166667h; Further stages.;
67%
tubercidin
69-33-0

tubercidin

(S)-2-tert-Butoxycarbonylamino-4-((S)-3-tert-butoxycarbonylamino-3-ethoxycarbonyl-propyldisulfanyl)-butyric acid ethyl ester
144385-04-6

(S)-2-tert-Butoxycarbonylamino-4-((S)-3-tert-butoxycarbonylamino-3-ethoxycarbonyl-propyldisulfanyl)-butyric acid ethyl ester

(S)-4-[(2S,3S,4R,5R)-5-(4-Amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-2-tert-butoxycarbonylamino-butyric acid ethyl ester

(S)-4-[(2S,3S,4R,5R)-5-(4-Amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-2-tert-butoxycarbonylamino-butyric acid ethyl ester

Conditions
ConditionsYield
With pyridine; triethylphosphine for 120h; Ambient temperature;66%
tubercidin
69-33-0

tubercidin

(2S,2'S)-dimethyl 4,4'-disulfanediylbis(2-(2,2,2-trifluoroacetamido)butanoate)
84355-09-9

(2S,2'S)-dimethyl 4,4'-disulfanediylbis(2-(2,2,2-trifluoroacetamido)butanoate)

(S)-4-[(2S,3S,4R,5R)-5-(4-Amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-2-(2,2,2-trifluoro-acetylamino)-butyric acid methyl ester
100804-03-3

(S)-4-[(2S,3S,4R,5R)-5-(4-Amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-2-(2,2,2-trifluoro-acetylamino)-butyric acid methyl ester

Conditions
ConditionsYield
With tributylphosphine In pyridine for 96h; Ambient temperature;62%
tubercidin
69-33-0

tubercidin

5-[131I]iodotubercidin

5-[131I]iodotubercidin

Conditions
ConditionsYield
With hydrogenchloride; [131I]-sodium iodide; N-chloro-4-methylbenzenesulfonamide; sodium hydroxide In ethanol; water at 20℃; for 0.05h; pH=7;61%
tubercidin
69-33-0

tubercidin

trityl chloride
76-83-5

trityl chloride

A

N6,5'-O-ditrityltubercidin
112135-89-4

N6,5'-O-ditrityltubercidin

B

5'-O-trityltubercidin
40983-03-7

5'-O-trityltubercidin

Conditions
ConditionsYield
With pyridine for 48h; Ambient temperature;A 22%
B 57%
tubercidin
69-33-0

tubercidin

(S)-2-Acetylamino-4-((S)-3-acetylamino-3-isopropoxycarbonyl-propyldisulfanyl)-butyric acid isopropyl ester

(S)-2-Acetylamino-4-((S)-3-acetylamino-3-isopropoxycarbonyl-propyldisulfanyl)-butyric acid isopropyl ester

(S)-2-Acetylamino-4-[(2S,3S,4R,5R)-5-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-butyric acid isopropyl ester

(S)-2-Acetylamino-4-[(2S,3S,4R,5R)-5-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-butyric acid isopropyl ester

Conditions
ConditionsYield
With pyridine; triethylphosphine for 96h; Ambient temperature;55%
tubercidin
69-33-0

tubercidin

prenyl bromide
870-63-3

prenyl bromide

N4-(Δ2-Isopentenyl)tubercidin
23589-13-1

N4-(Δ2-Isopentenyl)tubercidin

Conditions
ConditionsYield
In N,N,N,N,N,N-hexamethylphosphoric triamide for 24h; Heating;54%
tubercidin
69-33-0

tubercidin

(S)-4-[(S)-3-Ethoxycarbonyl-3-(2-methoxy-acetylamino)-propyldisulfanyl]-2-(2-methoxy-acetylamino)-butyric acid ethyl ester
144373-81-9

(S)-4-[(S)-3-Ethoxycarbonyl-3-(2-methoxy-acetylamino)-propyldisulfanyl]-2-(2-methoxy-acetylamino)-butyric acid ethyl ester

N-(methoxyacetyl)-S-tubercidinyl-L-homocysteine ethyl ester

N-(methoxyacetyl)-S-tubercidinyl-L-homocysteine ethyl ester

Conditions
ConditionsYield
With pyridine; triethylphosphine for 60h; Ambient temperature;54%
tubercidin
69-33-0

tubercidin

(S)-2-(2-Methoxy-acetylamino)-4-[(S)-3-(2-methoxy-acetylamino)-3-propoxycarbonyl-propyldisulfanyl]-butyric acid propyl ester
144373-82-0

(S)-2-(2-Methoxy-acetylamino)-4-[(S)-3-(2-methoxy-acetylamino)-3-propoxycarbonyl-propyldisulfanyl]-butyric acid propyl ester

N-(methoxyacetyl)-S-tubercidinyl-L-homocysteine propyl ester

N-(methoxyacetyl)-S-tubercidinyl-L-homocysteine propyl ester

Conditions
ConditionsYield
With pyridine; triethylphosphine for 96h; Ambient temperature;54%
tubercidin
69-33-0

tubercidin

(S)-4-[(S)-3-Isopropoxycarbonyl-3-(2-methoxy-acetylamino)-propyldisulfanyl]-2-(2-methoxy-acetylamino)-butyric acid isopropyl ester
144373-83-1

(S)-4-[(S)-3-Isopropoxycarbonyl-3-(2-methoxy-acetylamino)-propyldisulfanyl]-2-(2-methoxy-acetylamino)-butyric acid isopropyl ester

(S)-4-[(2S,3S,4R,5R)-5-(4-Amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-2-(2-methoxy-acetylamino)-butyric acid isopropyl ester

(S)-4-[(2S,3S,4R,5R)-5-(4-Amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-2-(2-methoxy-acetylamino)-butyric acid isopropyl ester

Conditions
ConditionsYield
With pyridine; triethylphosphine for 96h; Ambient temperature;53%
tubercidin
69-33-0

tubercidin

(S)-4-[(S)-3-Ethoxycarbonyl-3-(2,2,2-trifluoro-acetylamino)-propyldisulfanyl]-2-(2,2,2-trifluoro-acetylamino)-butyric acid ethyl ester
144373-75-1

(S)-4-[(S)-3-Ethoxycarbonyl-3-(2,2,2-trifluoro-acetylamino)-propyldisulfanyl]-2-(2,2,2-trifluoro-acetylamino)-butyric acid ethyl ester

(S)-4-[(2S,3S,4R,5R)-5-(4-Amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-2-(2,2,2-trifluoro-acetylamino)-butyric acid ethyl ester

(S)-4-[(2S,3S,4R,5R)-5-(4-Amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-2-(2,2,2-trifluoro-acetylamino)-butyric acid ethyl ester

Conditions
ConditionsYield
With pyridine; triethylphosphine for 70h; Ambient temperature;53%
tubercidin
69-33-0

tubercidin

(S)-2-Acetylamino-4-((S)-3-acetylamino-3-propoxycarbonyl-propyldisulfanyl)-butyric acid propyl ester
144373-79-5

(S)-2-Acetylamino-4-((S)-3-acetylamino-3-propoxycarbonyl-propyldisulfanyl)-butyric acid propyl ester

N-acetyl-S-tubercidinyl-L-homocysteine propyl ester

N-acetyl-S-tubercidinyl-L-homocysteine propyl ester

Conditions
ConditionsYield
With pyridine; triethylphosphine for 96h; Ambient temperature;48%

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