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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Deferoxamine Manufacturer/High quality/Best price/In stock

Cas:70-51-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Deferoxamine

Cas:70-51-9

Min.Order:1

Negotiable

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Deferoxamine

Cas:70-51-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White crystalline powder Storage: Ke

Deferoxamine CAS NO.70-51-9

Cas:70-51-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Deferoxamine CAS:70-51-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Deferoxamine CAS:70-51-9

Cas:70-51-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Desferrioxamine

Cas:70-51-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Deferoxamine

Cas:70-51-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Deferoxamine

Cas:70-51-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Deferoxamine

Cas:70-51-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Deferoxamine

Cas:70-51-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

70-51-9 Deferoxamine

Cas:70-51-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Deferoxamine

Cas:70-51-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Deferoxamine

Cas:70-51-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:API

99% up by HPLC Deferoxamine 70-51-9

Cas:70-51-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Deferoxamine

Cas:70-51-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

Deferoxamine

Cas:70-51-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Sinotech Import&Export Corporation

Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:Metabolism Drug; Poisoning Transportation:By sea or by air Port:Qingdao Port

Deferoxamine

Cas:70-51-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

70-51-9 CAS No.70-51-9

Cas:70-51-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

best seller Application:API

Deferoxamine

Cas:70-51-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary and sec

Deferoxamine

Cas:70-51-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Deferoxamine cas 70-51-9Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Deferoxamine cas 70-51-9

Cas:70-51-9

Min.Order:0

Negotiable

Type:Other

inquiry

Wuhan ZeShanCheng Biomedical Technology Co., Ltd.

we produce and sell good chemicals around the world.Appearance:white power Storage:Keep it in dry,shady and cool place Package:as your requirement Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:SEA OR AIR Port:China Main Po

Desferrioxamine

Cas:70-51-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Deferoxamine

Cas:70-51-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

Deferoxamine

Cas:70-51-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

70-51-9

Cas:70-51-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Muhuang Technology Co., Ltd

best seller Application:API

Deferoxamine

Cas:70-51-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Deferoxamine

Cas:70-51-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

Deferoxamine

Cas:70-51-9

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

C46H64N8O8

C46H64N8O8

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; acetic acid In methanol at 25℃; under 760.051 Torr; for 0.333333h;50%
1-Carbobenzoxyamino-6,17-dihydroxy-7,10,18,21-tetraoxy-27-(N-acetyl-hydroxyamino)-6,11,17,22-tetraaza-hepteikosan
402913-84-2

1-Carbobenzoxyamino-6,17-dihydroxy-7,10,18,21-tetraoxy-27-(N-acetyl-hydroxyamino)-6,11,17,22-tetraaza-hepteikosan

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; palladium on activated charcoal In methanol
N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(4-cyanobutyl)-N-(phenylmethoxy)butanediamide
112139-65-8

N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(4-cyanobutyl)-N-(phenylmethoxy)butanediamide

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; palladium on activated charcoal In methanol
N-(5-aminopentyl)-N-(tert-butoxycarbonyl)-O-benzylhydroxylamine
129245-21-2

N-(5-aminopentyl)-N-(tert-butoxycarbonyl)-O-benzylhydroxylamine

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 99 percent / diphenyl phosphorazidate, triethylamine / dimethylformamide / 17 h / 0 - 20 °C
2: 87 percent / trifluoroacetic acid (TFA) / CH2Cl2 / 0.75 h / 0 - 20 °C
3: 96 percent / pyridine
4: 95 percent / diphenyl phosphorazidate, triethylamine / dimethylformamide / 17 h / 0 - 20 °C
5: 100 percent / trifluoroacetic acid (TFA) / CH2Cl2
6: 91 percent / pyridine / 12 h
7: H2, HCl / 10percent Pd/C / methanol
View Scheme
5,16-bis(benzyloxy)-20-cyano-4,12,15-trioxo-5,11,16-triazaeicosanoic acid
129245-24-5

5,16-bis(benzyloxy)-20-cyano-4,12,15-trioxo-5,11,16-triazaeicosanoic acid

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95 percent / diphenyl phosphorazidate, triethylamine / dimethylformamide / 17 h / 0 - 20 °C
2: 100 percent / trifluoroacetic acid (TFA) / CH2Cl2
3: 91 percent / pyridine / 12 h
4: H2, HCl / 10percent Pd/C / methanol
View Scheme
27--6,17-bis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22-tetraazaheptacosanenitrile
130946-41-7

27--6,17-bis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22-tetraazaheptacosanenitrile

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / pyridine / 12 h
2: H2, HCl / 10percent Pd/C / methanol
View Scheme
27--6,17-bis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22-tetraazaheptacosanenitrile
130946-40-6

27--6,17-bis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22-tetraazaheptacosanenitrile

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / trifluoroacetic acid (TFA) / CH2Cl2
2: 91 percent / pyridine / 12 h
3: H2, HCl / 10percent Pd/C / methanol
View Scheme
N-(4-Cyanobutyl)-N-(benzyloxy)succinamic Acid
112139-60-3

N-(4-Cyanobutyl)-N-(benzyloxy)succinamic Acid

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 99 percent / diphenyl phosphorazidate, triethylamine / dimethylformamide / 17 h / 0 - 20 °C
2: 87 percent / trifluoroacetic acid (TFA) / CH2Cl2 / 0.75 h / 0 - 20 °C
3: 96 percent / pyridine
4: 95 percent / diphenyl phosphorazidate, triethylamine / dimethylformamide / 17 h / 0 - 20 °C
5: 100 percent / trifluoroacetic acid (TFA) / CH2Cl2
6: 91 percent / pyridine / 12 h
7: H2, HCl / 10percent Pd/C / methanol
View Scheme
N-(4-cyanobutyl)-3-<<5-<(benzyloxy)amino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid
129245-23-4

N-(4-cyanobutyl)-3-<<5-<(benzyloxy)amino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 96 percent / pyridine
2: 95 percent / diphenyl phosphorazidate, triethylamine / dimethylformamide / 17 h / 0 - 20 °C
3: 100 percent / trifluoroacetic acid (TFA) / CH2Cl2
4: 91 percent / pyridine / 12 h
5: H2, HCl / 10percent Pd/C / methanol
View Scheme
N-(4-cyanobutyl)-3-<<5-<(benzyloxy)-tert-butoxy-carbonylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid
129245-22-3

N-(4-cyanobutyl)-3-<<5-<(benzyloxy)-tert-butoxy-carbonylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 87 percent / trifluoroacetic acid (TFA) / CH2Cl2 / 0.75 h / 0 - 20 °C
2: 96 percent / pyridine
3: 95 percent / diphenyl phosphorazidate, triethylamine / dimethylformamide / 17 h / 0 - 20 °C
4: 100 percent / trifluoroacetic acid (TFA) / CH2Cl2
5: 91 percent / pyridine / 12 h
6: H2, HCl / 10percent Pd/C / methanol
View Scheme
1-(Carbobenzoxyamino)-5-(hydroxyamino)pentane
91905-05-4

1-(Carbobenzoxyamino)-5-(hydroxyamino)pentane

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Py
2: acetic anhydride / 5 h / 95 - 100 °C
3: (i) H2, Pd-C, MeOH, (ii) /BRN= 898057/
4: H2, aq. HCl / Pd-C / methanol
View Scheme
Multi-step reaction with 6 steps
1: Py
2: acetic anhydride / 5 h / 95 - 100 °C
3: (i) NaOMe, MeOH, (ii) /BRN= 898057/, THF
4: (i) aq. NH4Cl, Zn, EtOH, (ii) /BRN= 385737/, Py
5: (i) H2, Pd-C, MeOH, (ii) /BRN= 898057/
6: H2, aq. HCl / Pd-C / methanol
View Scheme
1-Carbobenzoxyamino-5-nitro-pentan
92034-20-3

1-Carbobenzoxyamino-5-nitro-pentan

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: aq. NH4Cl, Zn / ethanol
2: Py
3: acetic anhydride / 5 h / 95 - 100 °C
4: (i) H2, Pd-C, MeOH, (ii) /BRN= 898057/
5: H2, aq. HCl / Pd-C / methanol
View Scheme
Multi-step reaction with 7 steps
1: aq. NH4Cl, Zn / ethanol
2: Py
3: acetic anhydride / 5 h / 95 - 100 °C
4: (i) NaOMe, MeOH, (ii) /BRN= 898057/, THF
5: (i) aq. NH4Cl, Zn, EtOH, (ii) /BRN= 385737/, Py
6: (i) H2, Pd-C, MeOH, (ii) /BRN= 898057/
7: H2, aq. HCl / Pd-C / methanol
View Scheme
N-(5-benzyloxycarbonylamino-pentyl)-N-hydroxy-succinamic acid
106410-46-2

N-(5-benzyloxycarbonylamino-pentyl)-N-hydroxy-succinamic acid

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic anhydride / 5 h / 95 - 100 °C
2: (i) H2, Pd-C, MeOH, (ii) /BRN= 898057/
3: H2, aq. HCl / Pd-C / methanol
View Scheme
Multi-step reaction with 5 steps
1: acetic anhydride / 5 h / 95 - 100 °C
2: (i) NaOMe, MeOH, (ii) /BRN= 898057/, THF
3: (i) aq. NH4Cl, Zn, EtOH, (ii) /BRN= 385737/, Py
4: (i) H2, Pd-C, MeOH, (ii) /BRN= 898057/
5: H2, aq. HCl / Pd-C / methanol
View Scheme
1-Carbobenzoxyamino-6-hydroxy-16-nitro-7,10-dioxo-6,11-diaza-hexadecan
95228-06-1

1-Carbobenzoxyamino-6-hydroxy-16-nitro-7,10-dioxo-6,11-diaza-hexadecan

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (i) aq. NH4Cl, Zn, EtOH, (ii) /BRN= 385737/, Py
2: (i) H2, Pd-C, MeOH, (ii) /BRN= 898057/
3: H2, aq. HCl / Pd-C / methanol
View Scheme
N(1)-Benzyloxycarbonyl-6,17-dihydroxy-7,10,18-trioxo-6,11,17-triazanonadecylamin
95748-46-2

N(1)-Benzyloxycarbonyl-6,17-dihydroxy-7,10,18-trioxo-6,11,17-triazanonadecylamin

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) H2, Pd-C, MeOH, (ii) /BRN= 898057/
2: H2, aq. HCl / Pd-C / methanol
View Scheme
5-nitropentylammonium chloride

5-nitropentylammonium chloride

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: aq. NaOH
2: aq. NH4Cl, Zn / ethanol
3: Py
4: acetic anhydride / 5 h / 95 - 100 °C
5: (i) H2, Pd-C, MeOH, (ii) /BRN= 898057/
6: H2, aq. HCl / Pd-C / methanol
View Scheme
Multi-step reaction with 8 steps
1: aq. NaOH
2: aq. NH4Cl, Zn / ethanol
3: Py
4: acetic anhydride / 5 h / 95 - 100 °C
5: (i) NaOMe, MeOH, (ii) /BRN= 898057/, THF
6: (i) aq. NH4Cl, Zn, EtOH, (ii) /BRN= 385737/, Py
7: (i) H2, Pd-C, MeOH, (ii) /BRN= 898057/
8: H2, aq. HCl / Pd-C / methanol
View Scheme
[5-(3,6-dioxo-[1,2]oxazinan-2-yl)-pentyl]-carbamic acid benzyl ester
94622-86-3

[5-(3,6-dioxo-[1,2]oxazinan-2-yl)-pentyl]-carbamic acid benzyl ester

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) H2, Pd-C, MeOH, (ii) /BRN= 898057/
2: H2, aq. HCl / Pd-C / methanol
View Scheme
Multi-step reaction with 4 steps
1: (i) NaOMe, MeOH, (ii) /BRN= 898057/, THF
2: (i) aq. NH4Cl, Zn, EtOH, (ii) /BRN= 385737/, Py
3: (i) H2, Pd-C, MeOH, (ii) /BRN= 898057/
4: H2, aq. HCl / Pd-C / methanol
View Scheme
N-acetyl-N-hydroxy-1,5-diaminopentane
144108-69-0

N-acetyl-N-hydroxy-1,5-diaminopentane

4-((5-aminopentyl)(hydroxy)amino)-4-oxobutanoic acid

4-((5-aminopentyl)(hydroxy)amino)-4-oxobutanoic acid

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
With DesD Enzymatic reaction;
1,5-dibromo-pentane
111-24-0

1,5-dibromo-pentane

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium hydride / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
2: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C
3: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C
4: pyridine / 100 °C
5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
6: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
Multi-step reaction with 8 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
2.1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C
3.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C
4.1: pyridine / 100 °C
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere
6.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
6.2: 1 h / 80 °C
7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
8.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
Multi-step reaction with 9 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
2.1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C
3.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C
4.1: dmap / dichloromethane / 0.25 h / 0 - 20 °C
5.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
5.2: 1 h / 80 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere
7.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
7.2: 1 h / 80 °C
8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
9.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
1-Amino-5-pentane
83966-23-8

1-Amino-5-pentane

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere
2.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
2.2: 1 h / 80 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
4.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
tert-butyl(benzyloxy)(5-bromopentyl)carbamate

tert-butyl(benzyloxy)(5-bromopentyl)carbamate

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C
2: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C
3: pyridine / 100 °C
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
5: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
Multi-step reaction with 7 steps
1.1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C
2.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C
3.1: pyridine / 100 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere
5.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
5.2: 1 h / 80 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
7.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
Multi-step reaction with 8 steps
1.1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C
2.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C
3.1: dmap / dichloromethane / 0.25 h / 0 - 20 °C
4.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
4.2: 1 h / 80 °C
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere
6.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
6.2: 1 h / 80 °C
7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
8.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
t-butyl(5-azidopentyl)(benzyloxy)carbamate

t-butyl(5-azidopentyl)(benzyloxy)carbamate

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C
2: pyridine / 100 °C
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
4: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
Multi-step reaction with 6 steps
1.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C
2.1: pyridine / 100 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere
4.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
4.2: 1 h / 80 °C
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
6.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
Multi-step reaction with 7 steps
1.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C
2.1: dmap / dichloromethane / 0.25 h / 0 - 20 °C
3.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
3.2: 1 h / 80 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere
5.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
5.2: 1 h / 80 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
7.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
C14H20N4O2

C14H20N4O2

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
1.2: 1 h / 80 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere
3.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
3.2: 1 h / 80 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
5.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
C30H42N6O5

C30H42N6O5

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
1.2: 1 h / 80 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
3.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
C16H22N4O4

C16H22N4O4

N-(5-aminopentyl)-3-<<5-<(benzyloxy)acetylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid
112139-64-7

N-(5-aminopentyl)-3-<<5-<(benzyloxy)acetylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
2: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
N-(5-azidopentyl)-O-benzylhydroxylamine

N-(5-azidopentyl)-O-benzylhydroxylamine

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine / 100 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
3: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
Multi-step reaction with 5 steps
1.1: pyridine / 100 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere
3.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
3.2: 1 h / 80 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
5.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
Multi-step reaction with 6 steps
1.1: dmap / dichloromethane / 0.25 h / 0 - 20 °C
2.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
2.2: 1 h / 80 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere
4.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
4.2: 1 h / 80 °C
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
6.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
C16H22N4O4

C16H22N4O4

deferoxamine
70-51-9

deferoxamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere
2.1: triphenylphosphine / tetrahydrofuran / 1 h / 80 °C
2.2: 1 h / 80 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 25 °C / Inert atmosphere
4.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 0.33 h / 25 °C / 760.05 Torr
View Scheme
deferoxamine
70-51-9

deferoxamine

water
7732-18-5

water

zirconium(IV) chloride
10026-11-6

zirconium(IV) chloride

zirconium(IV) desferrioxamine(OH)2

zirconium(IV) desferrioxamine(OH)2

Conditions
ConditionsYield
at 20℃; for 24h;100%
deferoxamine
70-51-9

deferoxamine

formic acid ethyl ester
109-94-4

formic acid ethyl ester

formamide deferoxamine

formamide deferoxamine

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide for 15h; Heating;90%
1 ,4-phenylenediisothiocyanate
4044-65-9

1 ,4-phenylenediisothiocyanate

deferoxamine
70-51-9

deferoxamine

N-[5-({3-[5-(acetyl-hydroxy-amino)-pentylcarbamoyl]-propionyl}-hydroxy-amino)-pentyl]-N'-hydroxy-N'-{5-[3-(4-isothiocyanato-phenyl)-thioureido]-pentyl}-succinamide
1222468-90-7

N-[5-({3-[5-(acetyl-hydroxy-amino)-pentylcarbamoyl]-propionyl}-hydroxy-amino)-pentyl]-N'-hydroxy-N'-{5-[3-(4-isothiocyanato-phenyl)-thioureido]-pentyl}-succinamide

Conditions
ConditionsYield
With triethylamine In chloroform; water; isopropyl alcohol at 20℃; for 1.5h;89%
deferoxamine
70-51-9

deferoxamine

3,4-dimethoxy-3-cyclobutene-1,2-dione
5222-73-1

3,4-dimethoxy-3-cyclobutene-1,2-dione

C30H50N6O11
1300025-15-3

C30H50N6O11

Conditions
ConditionsYield
With triethylamine In methanol at 23℃; for 6h; Inert atmosphere;88%
3-(4-nitrophenyl)-1-adamantanecarboxylic acid
7123-76-4

3-(4-nitrophenyl)-1-adamantanecarboxylic acid

deferoxamine
70-51-9

deferoxamine

C42H65N7O11

C42H65N7O11

Conditions
ConditionsYield
Stage #1: 3-(4-nitrophenyl)-1-adamantanecarboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
71%
deferoxamine
70-51-9

deferoxamine

4-pentylbicyclo[2.2.2]octane-1-carboxylic acid

4-pentylbicyclo[2.2.2]octane-1-carboxylic acid

C39H70N6O9

C39H70N6O9

Conditions
ConditionsYield
Stage #1: 4-pentylbicyclo[2.2.2]octane-1-carboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
66%
deferoxamine
70-51-9

deferoxamine

C22H23NO7

C22H23NO7

C47H69N7O14

C47H69N7O14

Conditions
ConditionsYield
Stage #1: C22H23NO7 With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In N,N-dimethyl-formamide for 0.166667h; Cooling with ice;
Stage #2: deferoxamine With 4-methyl-morpholine; potassium hydroxide In water; N,N-dimethyl-formamide at 20℃; for 96h;
58%
3-bromoadamantane-1-carboxylic acid
21816-08-0

3-bromoadamantane-1-carboxylic acid

deferoxamine
70-51-9

deferoxamine

C36H61BrN6O9

C36H61BrN6O9

Conditions
ConditionsYield
Stage #1: 3-bromoadamantane-1-carboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
52%
1-chloro-3-adamantanecarboxylic acid
34859-74-0

1-chloro-3-adamantanecarboxylic acid

deferoxamine
70-51-9

deferoxamine

C36H61ClN6O9

C36H61ClN6O9

Conditions
ConditionsYield
Stage #1: 3-chloroadamantane-1-carboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
47%
deferoxamine
70-51-9

deferoxamine

C17H23NO4

C17H23NO4

N1-(5-((1r,3R,5S,7r)-3,5-dimethyladamantane-1-carboxamido)pentyl)-N1-hydroxy-N4-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)pentyl)amino)-4-oxobutanamido)pentyl)succinamide

N1-(5-((1r,3R,5S,7r)-3,5-dimethyladamantane-1-carboxamido)pentyl)-N1-hydroxy-N4-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)pentyl)amino)-4-oxobutanamido)pentyl)succinamide

Conditions
ConditionsYield
With sodium hydroxide In methanol at 70℃; for 3h;44%
(3-bromo-1-adamantyl)acetic acid
17768-34-2

(3-bromo-1-adamantyl)acetic acid

deferoxamine
70-51-9

deferoxamine

C37H63BrN6O9

C37H63BrN6O9

Conditions
ConditionsYield
Stage #1: (3-bromo-1-adamantyl)acetic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
35%
deferoxamine
70-51-9

deferoxamine

2-(3-hydroxyadamantan-1-yl)acetic acid
17768-36-4

2-(3-hydroxyadamantan-1-yl)acetic acid

C37H64N6O10

C37H64N6O10

Conditions
ConditionsYield
Stage #1: (3-hydroxyadamantan-1-yl)acetic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
34%
3,5-dimethyladamantane-1-acetic acid
14202-14-3

3,5-dimethyladamantane-1-acetic acid

deferoxamine
70-51-9

deferoxamine

C39H68N6O9

C39H68N6O9

Conditions
ConditionsYield
Stage #1: acide dimethyl-3,5 adamantylacetique With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
28%
3,5,7-trimethyladamantanecarboxylic acid
15291-66-4

3,5,7-trimethyladamantanecarboxylic acid

deferoxamine
70-51-9

deferoxamine

C39H68N6O9

C39H68N6O9

Conditions
ConditionsYield
Stage #1: 3,5,7-trimethyladamantanecarboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
27%
3,5-dimethyl-1-adamantanecarboxylic acid
14670-94-1

3,5-dimethyl-1-adamantanecarboxylic acid

deferoxamine
70-51-9

deferoxamine

DFOB-AdAdMe
1149568-52-4

DFOB-AdAdMe

Conditions
ConditionsYield
Stage #1: 3,5-dimethyl-1-adamantanecarboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
24%
1-Adamantanecarboxylic acid
828-51-3

1-Adamantanecarboxylic acid

deferoxamine
70-51-9

deferoxamine

DFOB-AdA
1150314-06-9

DFOB-AdA

Conditions
ConditionsYield
Stage #1: 1-Adamantanecarboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
22%
deferoxamine
70-51-9

deferoxamine

2-((2'-((((2'',5''-dioxopyrrolidin-1''-yl)oxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2'''-butyl-1''',3'''-dioxo-2''',3'''-dihydro-1H-benzo[de]isoquinolin-6'''-yl)carbamate

2-((2'-((((2'',5''-dioxopyrrolidin-1''-yl)oxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2'''-butyl-1''',3'''-dioxo-2''',3'''-dihydro-1H-benzo[de]isoquinolin-6'''-yl)carbamate

C47H70N8O14S2

C47H70N8O14S2

Conditions
ConditionsYield
In tetrahydrofuran; aq. phosphate buffer at 20℃; for 14h; pH=8; Inert atmosphere;21%
deferoxamine
70-51-9

deferoxamine

Cyclohexanecarboxylic acid
98-89-5

Cyclohexanecarboxylic acid

C32H58N6O9

C32H58N6O9

Conditions
ConditionsYield
Stage #1: Cyclohexanecarboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
21%
deferoxamine
70-51-9

deferoxamine

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

methylsulfonamide deferoxamine

methylsulfonamide deferoxamine

Conditions
ConditionsYield
With iron(III) chloride In chloroform for 0.5h; pH=8.5;20%
3-noradamantanecarboxylic acid
16200-53-6

3-noradamantanecarboxylic acid

deferoxamine
70-51-9

deferoxamine

C35H60N6O9

C35H60N6O9

Conditions
ConditionsYield
Stage #1: 3-noradamantanecarboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
19%
endo-bicyclo<3,3,1>nonan-3-carboxylic acid
6221-62-1

endo-bicyclo<3,3,1>nonan-3-carboxylic acid

deferoxamine
70-51-9

deferoxamine

C35H62N6O9

C35H62N6O9

Conditions
ConditionsYield
Stage #1: endo-bicyclo<3,3,1>nonan-3-carboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
17%
deferoxamine
70-51-9

deferoxamine

C33H56N6O9

C33H56N6O9

Conditions
ConditionsYield
Stage #1: (+)-(1R,4R,5S)-bicyclo<2.2.1>hept-2-ene-5-carboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
17%
deferoxamine
70-51-9

deferoxamine

C16H26N4O8

C16H26N4O8

N’-(1-azido-15-oxo-3,6,9,12-tetraoxa-16-azahenicosan-21-yl)-N1-hydroxy-N”-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)pentyl)amino)-4-oxobutanamido)pentyl)-succinamide

N’-(1-azido-15-oxo-3,6,9,12-tetraoxa-16-azahenicosan-21-yl)-N1-hydroxy-N”-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)pentyl)amino)-4-oxobutanamido)pentyl)-succinamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 40 - 45℃; for 7h; Inert atmosphere;15%
deferoxamine
70-51-9

deferoxamine

11-hydroxy-2,2-dimethyl-4,12-dioxo-3,8-dioxa-5,11-diazapentadecan-15-oic acid

11-hydroxy-2,2-dimethyl-4,12-dioxo-3,8-dioxa-5,11-diazapentadecan-15-oic acid

N1-(1-amino-6,17-dihydroxy-7,10,18,21-tetraoxo-3-oxa-6,11,17,22-tetraazaheptacosan-27-yl)-N1-hydroxy-N4-(5-(N-hydroxyacetamido)pentyl)succinamide

N1-(1-amino-6,17-dihydroxy-7,10,18,21-tetraoxo-3-oxa-6,11,17,22-tetraazaheptacosan-27-yl)-N1-hydroxy-N4-(5-(N-hydroxyacetamido)pentyl)succinamide

Conditions
ConditionsYield
Stage #1: 11-hydroxy-2,2-dimethyl-4,12-dioxo-3,8-dioxa-5,11-diazapentadecan-15-oic acid With di(succinimido) carbonate; triethylamine In N,N-dimethyl-formamide for 4h; Inert atmosphere;
Stage #2: deferoxamine In N,N-dimethyl-formamide Inert atmosphere;
Stage #3: With trifluoroacetic acid In dichloromethane for 2h; Inert atmosphere;
12%
deferoxamine
70-51-9

deferoxamine

(1R,4R)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

(1R,4R)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

C33H56N6O9

C33H56N6O9

Conditions
ConditionsYield
Stage #1: (1R,4R)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
11%
di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

deferoxamine
70-51-9

deferoxamine

methyl (1S,4E,6R)-6-{[(4-{[(2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethyl)carbamoyl] (hydroxy)methyl}phenyl)(methyl)carbamoyl]oxy}-1-hydroxycyclooct-4-ene-1-carboxylate

methyl (1S,4E,6R)-6-{[(4-{[(2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethyl)carbamoyl] (hydroxy)methyl}phenyl)(methyl)carbamoyl]oxy}-1-hydroxycyclooct-4-ene-1-carboxylate

TCO-mandelic-(PEG2-Mal)-DFO

TCO-mandelic-(PEG2-Mal)-DFO

Conditions
ConditionsYield
Stage #1: di(succinimido) carbonate; methyl (1S,4E,6R)-6-{[(4-{[(2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethyl)carbamoyl] (hydroxy)methyl}phenyl)(methyl)carbamoyl]oxy}-1-hydroxycyclooct-4-ene-1-carboxylate With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 20℃; for 96h;
Stage #2: deferoxamine In dimethyl sulfoxide at 20℃; for 1h;
11%
deferoxamine
70-51-9

deferoxamine

bicyclo<2.2.1>heptane-2-carboxylic acid
870708-34-2

bicyclo<2.2.1>heptane-2-carboxylic acid

C33H58N6O9

C33H58N6O9

Conditions
ConditionsYield
Stage #1: bicyclo<2.2.1>heptane-2-carboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
8%
deferoxamine
70-51-9

deferoxamine

2-((1S,4R)-bicyclo[2.2.1]heptan-2-yl)acetic acid

2-((1S,4R)-bicyclo[2.2.1]heptan-2-yl)acetic acid

C34H60N6O9

C34H60N6O9

Conditions
ConditionsYield
Stage #1: 2-((1S,4R)-bicyclo[2.2.1]heptan-2-yl)acetic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
Stage #2: deferoxamine With sodium hydroxide In methanol at 70℃; for 3h; Inert atmosphere;
8%

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