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GL Biochem (Shanghai) Ltd.

CAS#71989-28-1 Fmoc-L-Met-OH which is coded as 35601 is a catalogue compound synthesized/supplied by GL Biochem. Its specifications & structural Indications are as follows. This material is intended for the R&D and industrial production

Fmoc-L-Met-OH / Fmoc-Met-OH / Fmoc-L-Methionine

Cas:71989-28-1

Min.Order:1 Gram

FOB Price: $6.0 / 30.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Fmoc-L-Methionine Manufacturer/High quality/Best price/In stock

Cas:71989-28-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Fmoc-Met-Oh supplier in China

Cas:71989-28-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermediate Transpo

Manufacturer high quality FMOC-L-Methionine Cas 71989-28-1 with good price

Cas:71989-28-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable

Fmoc--L-Met-OH

Cas:71989-28-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high purity Appearance:White to white powder Storage:cold storage Package:meet the demand of customer Application:Biomedical reagents Transportation:by sea or by air Port:shanghai

FMOC-MET-OH

Cas:71989-28-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008, production and quality manage

Fmoc-L-Methionine

Cas:71989-28-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Nα-9-Fluorenylmethoxycarbonyl-L-methionine

Cas:71989-28-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:FMOC-L-Methionine CAS NO:71989-28-1 Grade:Medical scientific research and export Molecular formula:C20H21NO4S Molecular weight:371.45 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability

FMOC-L-Methionine/ CAS:71989-28-1/FMOC-L-Methionine raw material/ high-quality

Cas:71989-28-1

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Leader Biochemical Group

About Product Technical Details

China Largest factory Manufacturer Supply High Quality FMOC-L-Methionine CAS 71989-28-1

Cas:71989-28-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Fmoc-L-Methionine / Fmoc-L-Met / CAS 71989-28-1

Cas:71989-28-1

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Valued High QualityCAS 71989-28-1 with best price

Cas:71989-28-1

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name Fmoc-Met-OH CAS No. 71989-28-1 Synonyms FMOC-L-Methionine Purity 98.0% min Molecular Formula C20H21NO4S Molecular Weight 371.5 Appearance: white powder Stor

Fmoc-Met-OH

Cas:71989-28-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White to off-white crystalline powder Storage:Store in seale

Fmoc-L-Methionine CAS 71989-28-1 white crystalline powder

Cas:71989-28-1

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Fmoc-L-Methionine 71989-28-1

Cas:71989-28-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

EINECS No.:204-879-3 Place of Origin:Shaanxi, China (Mainland) Type:Anesthetic Agents, Anti-Allergic Agents, Antibiotic and Antimicrobial Agents, Antineoplastic Agents, Central Nervous System Agents Grade Standard:Cosmetic Grade, Feed Grade,

High quality cas 71989-28-1 Fmoc-L-Methionine

Cas:71989-28-1

Min.Order:1 Kilogram

FOB Price: $8.0 / 256.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

FMOC-L-Methionine CAS:71989-28-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interme

FMOC-L-Methionine CAS:71989-28-1

Cas:71989-28-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home

Fmoc-L-Met-OH

Cas:71989-28-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

FMOC-L-Methionine

Cas:71989-28-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

FMOC-L-Methionine

Cas:71989-28-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

FMOC-L-METHIONINE

Cas:71989-28-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Fmoc-Met-OH

Cas:71989-28-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply FMOC-L-Methionine

Cas:71989-28-1

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Fmoc-L-Methionine

Cas:71989-28-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Fmoc-Met-Oh

Cas:71989-28-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

High purity Fmoc-Met-OH 71989-28-1 in stock immediately delivery good supplierAppearance:Powder Storage:Dry and ventilated Package:according to customers' requirements Application:APIs Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by s

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used for Pesticide intermediates T

FMOC-L-Methionine

Cas:71989-28-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

FMOC-L-Methionine 71989-28-1 FMOC-L-Methionine Basic information Product Name: FMOC-L-Methionine Synonyms: N-ALPHA-FMOC-L-METHIONINE;N-(9-FLUORENYLMETHOXYCARBONYL)-L-METHIONINE;N-[(9H-

TIANFU-CHEM_FMOC-L-Methionine 71989-28-1

Cas:71989-28-1

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: FMOC-L-Met-OH CAS No.:71989-28-1 Molecule Formula:C20H20NO4S Molecule Weight:370.44 Purity: 99.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise Standard TES

High Quality FMOC-L-Met-OH

Cas:71989-28-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Fmoc-L-methionine

Cas:71989-28-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Synthetic route

2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanyl-butyric acid methyl ester
500872-34-4

2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanyl-butyric acid methyl ester

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
With aluminium trichloride; N,N-dimethyl-aniline In dichloromethane98%
L-methionine
63-68-3

L-methionine

(9-fluorenyl)methyl pentafluorophenyl carbonate
88744-04-1

(9-fluorenyl)methyl pentafluorophenyl carbonate

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; acetone Ambient temperature;84%
L-methionine
63-68-3

L-methionine

1-[(9-fluorenylmethyloxycarbonyl)]benzotriazole
1131148-55-4

1-[(9-fluorenylmethyloxycarbonyl)]benzotriazole

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
With triethylamine In water; acetonitrile at 20℃; for 2h;84%
L-methionine
63-68-3

L-methionine

4-(9-fluorenylmethoxycarbonyloxy) phenyl dimethylsulfonium methylsulfate

4-(9-fluorenylmethoxycarbonyloxy) phenyl dimethylsulfonium methylsulfate

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
With triethylamine In water Ambient temperature;80%
L-methionine
63-68-3

L-methionine

(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
Stage #1: L-methionine With chloro-trimethyl-silane In dichloromethane for 1h; Inert atmosphere; Reflux;
Stage #2: (fluorenylmethoxy)carbonyl chloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 5 - 20℃; for 1.5h;
80%
In acetonitrile at 20℃; for 0.25h; pH=9.2; aq. borate buffer;
Stage #1: L-methionine With sodium carbonate In 1,4-dioxane; water Cooling with ice;
Stage #2: (fluorenylmethoxy)carbonyl chloride In 1,4-dioxane; water at 20℃; for 5h;
L-methionine
63-68-3

L-methionine

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 50℃;78%
Stage #1: L-methionine With N-cyclohexyl-cyclohexanamine In acetone at 20℃;
Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide With sodium carbonate In water; acetonitrile at 0 - 20℃; pH=8;
Stage #3: With potassium hydrogensulfate In water; acetonitrile pH=2 - 3;
61%
With sodium hydrogencarbonate In water; N,N-dimethyl-formamide at 0 - 20℃; for 2h;
C23H29NO4SSi

C23H29NO4SSi

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
With methanol In dichloromethane for 0.5h; Ambient temperature; Yield given;
N-Fmoc-L-methionine phenacyl ester

N-Fmoc-L-methionine phenacyl ester

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
With magnesium; acetic acid In methanol; N,N-dimethyl-formamide at 20℃; for 75h;
L-methionine
63-68-3

L-methionine

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: CH2Cl2 / 1 h / Heating
2: CH2Cl2 / 72 h / Ambient temperature
3: MeOH / CH2Cl2 / 0.5 h / Ambient temperature
View Scheme
O-(Trimethylsilyl)methionine
5269-64-7

O-(Trimethylsilyl)methionine

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CH2Cl2 / 72 h / Ambient temperature
2: MeOH / CH2Cl2 / 0.5 h / Ambient temperature
View Scheme
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 2 h / 10 °C
2: triethylamine / water; acetonitrile / 2 h / 20 °C
View Scheme
picolyl N-Fmoc-L-methioninate
1361400-97-6

picolyl N-Fmoc-L-methioninate

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
With magnesium In methanol at 20℃; for 4h;
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

A

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

B

Nα-fluorenyl-9-methoxycarbonyl-D-Met
71989-28-1, 144701-23-5, 112883-40-6

Nα-fluorenyl-9-methoxycarbonyl-D-Met

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium carbonate / water; 1,4-dioxane / Cooling with ice
1.2: 5 h / 20 °C
2.1: trifluoroacetic acid / isopropyl alcohol; hexane / 25 °C / Resolution of racemate
View Scheme
N-Fmoc-methionine
144701-23-5

N-Fmoc-methionine

A

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

B

Nα-fluorenyl-9-methoxycarbonyl-D-Met
71989-28-1, 144701-23-5, 112883-40-6

Nα-fluorenyl-9-methoxycarbonyl-D-Met

Conditions
ConditionsYield
With trifluoroacetic acid In hexane; isopropyl alcohol at 25℃; Reagent/catalyst; Resolution of racemate;
With chiral column based on 3,5-dimethylphenylcarbamoylated β-cyclodextrin combining cinchona alkaloid immobilized on silica gel In methanol; formic acid; triethylamine; acetonitrile at 25℃; Reagent/catalyst; Resolution of racemate; enantioselective reaction;
DL-methionine
59-51-8

DL-methionine

A

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

B

Nα-fluorenyl-9-methoxycarbonyl-D-Met
71989-28-1, 144701-23-5, 112883-40-6

Nα-fluorenyl-9-methoxycarbonyl-D-Met

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium carbonate / water; 1,4-dioxane / Cooling with ice
1.2: 5 h / 20 °C
2.1: trifluoroacetic acid / isopropyl alcohol; hexane / 25 °C / Resolution of racemate
View Scheme
mono-oxidized L-methionine

mono-oxidized L-methionine

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
Stage #1: mono-oxidized L-methionine With chloro-trimethyl-silane In N,N-dimethyl-formamide at 20℃; Pummerer Sulfoxide Rearrangement;
Stage #2: With 1,3-dihydro-imidazole-2-thione In N,N-dimethyl-formamide at 20℃; Solvent; Reagent/catalyst; Pummerer Sulfoxide Rearrangement;
90 %Chromat.
1,3-dihydro-imidazole-2-thione
872-35-5

1,3-dihydro-imidazole-2-thione

mono-oxidized L-methionine

mono-oxidized L-methionine

A

C23H23N3O4S2

C23H23N3O4S2

B

S-(((1H-imidazol-2-yl)thio)methyl)-N-(((9H-fluoren-9-yl)methoxy)carbonyl)-L-homocysteine

S-(((1H-imidazol-2-yl)thio)methyl)-N-(((9H-fluoren-9-yl)methoxy)carbonyl)-L-homocysteine

C

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Conditions
ConditionsYield
Stage #1: mono-oxidized L-methionine With chloro-trimethyl-silane In ethyl acetate at 20℃; Pummerer Sulfoxide Rearrangement;
Stage #2: 1,3-dihydro-imidazole-2-thione In ethyl acetate at 20℃; Solvent; Reagent/catalyst; Pummerer Sulfoxide Rearrangement;
A n/a
B n/a
C 8 %Chromat.
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

(9H-fluoren-9-yl)methyl (S)-(1-amino-4-(methylthio)-1-oxobutan-2-yl)carbamate
314732-61-1

(9H-fluoren-9-yl)methyl (S)-(1-amino-4-(methylthio)-1-oxobutan-2-yl)carbamate

Conditions
ConditionsYield
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: With ammonium chloride In tetrahydrofuran; water at 0℃; for 0.5h;
100%
With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate In 1,4-dioxane; N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere;91%
With ammonium bicarbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In acetonitrile at 20℃; for 15h;86%
Fmoc-Leu-OH
35661-60-0

Fmoc-Leu-OH

Fmoc-Pro-OH
71989-31-6

Fmoc-Pro-OH

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

trifluoroacetic acid
76-05-1

trifluoroacetic acid

(4S)-4-{[(9-fluorenylmethyloxy)carbonyl]amino}-5-({2-[([(2-{[(9H-fluorenylmethoxy)carbonyl]amino}ethyl)amino]{[(4-methylphenyl)-sulfonyl]imino}methyl)amino]ethyl}amino)-5-oxopentanoic acid

(4S)-4-{[(9-fluorenylmethyloxy)carbonyl]amino}-5-({2-[([(2-{[(9H-fluorenylmethoxy)carbonyl]amino}ethyl)amino]{[(4-methylphenyl)-sulfonyl]imino}methyl)amino]ethyl}amino)-5-oxopentanoic acid

C49H83N13O10S3*C2HF3O2

C49H83N13O10S3*C2HF3O2

Conditions
ConditionsYield
Multistep reaction.;100%
C42H37ClNO6Pol

C42H37ClNO6Pol

C29H31NO5

C29H31NO5

N-Cbz-L-Phe
1161-13-3

N-Cbz-L-Phe

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine
35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

O-benzyl-N-Fmoc-L-serine
122889-11-6, 83792-48-7

O-benzyl-N-Fmoc-L-serine

Fmoc-Pro-OH
71989-31-6

Fmoc-Pro-OH

Fmoc-Ser(tBu)-OH
71989-33-8

Fmoc-Ser(tBu)-OH

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Nα-FMOC-Nω-L-tosylarginine
139090-50-9, 83792-47-6

Nα-FMOC-Nω-L-tosylarginine

N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyldimethylsilyl)-L-threonine
146346-82-9

N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyldimethylsilyl)-L-threonine

N-alpha-(9-fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester
146982-24-3

N-alpha-(9-fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester

Z-Phe-Ala-Thr(TBS)-Met-Arg(Tos)-Tyr(Pen)-Pro-Ser(tBu)-Asp(OAll)-Ser(Bzl)-Asp(OtBu)-OH
1240360-55-7

Z-Phe-Ala-Thr(TBS)-Met-Arg(Tos)-Tyr(Pen)-Pro-Ser(tBu)-Asp(OAll)-Ser(Bzl)-Asp(OtBu)-OH

Conditions
ConditionsYield
Stage #1: C42H37ClNO6Pol With morpholine Automated synthesizer; solid phase reaction;
Stage #2: O-benzyl-N-Fmoc-L-serine With O‑(6‑chlorobezotriazol‑1‑yl)‑N,N,N,N‑tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole In 1-methyl-pyrrolidin-2-one Automated synthesizer; solid phase reaction;
Stage #3: C29H31NO5; N-Cbz-L-Phe; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Pro-OH; Fmoc-Ser(tBu)-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine; Nα-FMOC-Nω-L-tosylarginine; N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyldimethylsilyl)-L-threonine; N-alpha-(9-fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester Further stages;
100%
N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

Fmoc-Glu(OtBu)-OH
71989-18-9

Fmoc-Glu(OtBu)-OH

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

N3-L-Gly-L-Phe-L-Glu(OtBu)-L-Met-L-Glu(OtBu)-L-Met-OH

N3-L-Gly-L-Phe-L-Glu(OtBu)-L-Met-L-Glu(OtBu)-L-Met-OH

Conditions
ConditionsYield
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine With N-ethyl-N,N-diisopropylamine In methanol; dichloromethane; N,N-dimethyl-formamide for 1.33333h; Inert atmosphere;
Stage #2: With piperidine In N,N-dimethyl-formamide for 0.333333h; Inert atmosphere;
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; N-Fmoc L-Phe; Fmoc-Glu(OtBu)-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine Further stages;
99%
N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Fmoc-L-Phe-L-Met-L-Phe-L-Met-OH

Fmoc-L-Phe-L-Met-L-Phe-L-Met-OH

Conditions
ConditionsYield
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine With N-ethyl-N,N-diisopropylamine In methanol; dichloromethane; N,N-dimethyl-formamide for 1.33333h; Inert atmosphere;
Stage #2: With piperidine In N,N-dimethyl-formamide for 0.333333h; Inert atmosphere;
Stage #3: N-Fmoc L-Phe; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine Further stages;
99%
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine With N-ethyl-N,N-diisopropylamine In dichloromethane for 1.08333h; Inert atmosphere;
Stage #2: With piperidine In N,N-dimethyl-formamide for 0.166667h; Inert atmosphere;
Stage #3: N-Fmoc L-Phe; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine Further stages;
99%
N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Nα-(9-fluorenylmethoxycarbonyl)-L-glutamic acid α-allyl ester
144120-54-7

Nα-(9-fluorenylmethoxycarbonyl)-L-glutamic acid α-allyl ester

cyclo-[L-Met-Gly-L-Met-L-Phe-L-Phe-L-Glu]

cyclo-[L-Met-Gly-L-Met-L-Phe-L-Phe-L-Glu]

Conditions
ConditionsYield
Stage #1: Nα-(9-fluorenylmethoxycarbonyl)-L-glutamic acid α-allyl ester With N-ethyl-N,N-diisopropylamine In dichloromethane for 0.916667h;
Stage #2: With piperidine In N,N-dimethyl-formamide for 0.333333h;
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; N-Fmoc L-Phe; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine Further stages;
99%
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

1-methyl-1-phenylethyl 2,2,2-trichloroacetimidoate
147221-33-8

1-methyl-1-phenylethyl 2,2,2-trichloroacetimidoate

(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanyl-butyric acid 1-methyl-1-phenyl-ethyl ester

(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanyl-butyric acid 1-methyl-1-phenyl-ethyl ester

Conditions
ConditionsYield
In dichloromethane98%
In dichloromethane at 20℃; for 16h;95%
N-(2,2-diethoxyethyl)-3-methylbutan-1-amine
103647-81-0

N-(2,2-diethoxyethyl)-3-methylbutan-1-amine

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

(S)-(9H-fluoren-9-yl)methyl 1-((2,2-diethoxyethyl)(isopentyl)amino)-4-(methylthio)-1-oxobutan-2-ylcarbamate

(S)-(9H-fluoren-9-yl)methyl 1-((2,2-diethoxyethyl)(isopentyl)amino)-4-(methylthio)-1-oxobutan-2-ylcarbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; Cooling with ice;98%
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

3-hydroxy-3,4-dihydrobenzotriazine-4-one
28230-32-2

3-hydroxy-3,4-dihydrobenzotriazine-4-one

Fmoc-Met-ODhbt
119767-83-8

Fmoc-Met-ODhbt

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran at -15 - 4℃;95%
With thionyl chloride In dichloromethane Heating;92%
tert-Butyl 2,2,2-trichloroacetimidate
98946-18-0

tert-Butyl 2,2,2-trichloroacetimidate

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanyl-butyric acid tert-butyl ester

(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanyl-butyric acid tert-butyl ester

Conditions
ConditionsYield
In dichloromethane Heating;95%
(4-iodomethylphenoxy)acetic acid 2-oxo-2-phenylethyl ester
913987-81-2

(4-iodomethylphenoxy)acetic acid 2-oxo-2-phenylethyl ester

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

4-(Fmoc-methionyloxymethyl)phenoxyacetic acid 2-phenacyl ester
913987-86-7

4-(Fmoc-methionyloxymethyl)phenoxyacetic acid 2-phenacyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine at 0℃;95%
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

L-methionine
63-68-3

L-methionine

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide at 50℃; for 16h;95%
formaldehyd
50-00-0

formaldehyd

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

(4S)-3-(9-fluorenylmethyloxycarbonyl)-4-<2-(methylthio)ethyl>-5-oxooxazolidine
84000-02-2

(4S)-3-(9-fluorenylmethyloxycarbonyl)-4-<2-(methylthio)ethyl>-5-oxooxazolidine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 2h; Reflux;94%
With toluene-4-sulfonic acid In toluene for 0.5h; Heating;88%
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

α-bromoacetophenone
70-11-1

α-bromoacetophenone

N-Fmoc-L-methionine phenacyl ester

N-Fmoc-L-methionine phenacyl ester

Conditions
ConditionsYield
With triethylamine In ethyl acetate; N,N-dimethyl-formamide at 0℃; for 18h;94%
(E)-1α,25-dihydroxy-2-(1′-amino-3′,6′,9′-trioxadodecan-12′-ylidene)-19-norvitamin D3

(E)-1α,25-dihydroxy-2-(1′-amino-3′,6′,9′-trioxadodecan-12′-ylidene)-19-norvitamin D3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

(E)-1α,25-dihydroxy-2-[1′-(9′’H-fluoren-9′’-yl)-5′-[2′’’-(methylthio)ethyl]-3′,6′-dioxo-2′,10′,13′,16′-tetraoxa-4′,7′-diazanonadecan-19′-ylidene]-19-norvitamin D3

(E)-1α,25-dihydroxy-2-[1′-(9′’H-fluoren-9′’-yl)-5′-[2′’’-(methylthio)ethyl]-3′,6′-dioxo-2′,10′,13′,16′-tetraoxa-4′,7′-diazanonadecan-19′-ylidene]-19-norvitamin D3

Conditions
ConditionsYield
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 1h; Inert atmosphere;
Stage #2: (E)-1α,25-dihydroxy-2-(1′-amino-3′,6′,9′-trioxadodecan-12′-ylidene)-19-norvitamin D3 In dichloromethane Inert atmosphere;
94%
2,3,4,5,6-pentafluorophenol
771-61-9

2,3,4,5,6-pentafluorophenol

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

N-α-Fmoc-L-methionine pentafluorophenyl ester
86060-94-8

N-α-Fmoc-L-methionine pentafluorophenyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In ethyl acetate 0 deg C, 1 h; r.t., 1 h;93%
With dicyclohexyl-carbodiimide In ethyl acetate at 0℃; for 2h; Yield given;
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

pentafluorophenyl 4-nitrobenzenesulfonate
244633-31-6

pentafluorophenyl 4-nitrobenzenesulfonate

N-α-Fmoc-L-methionine pentafluorophenyl ester
86060-94-8

N-α-Fmoc-L-methionine pentafluorophenyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; Esterification;93%
methyl 2-aminoisobutyrate hydrochloride
15028-41-8

methyl 2-aminoisobutyrate hydrochloride

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Fmoc-L-Met-Aib-OMe
1124322-46-8

Fmoc-L-Met-Aib-OMe

Conditions
ConditionsYield
With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;93%
2-docosyloxy-4-methoxybenzyl alcohol
1313025-22-7

2-docosyloxy-4-methoxybenzyl alcohol

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

C50H73NO6S
1313025-44-3

C50H73NO6S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform at 20℃; for 1h; Cooling with ice;93%
L-leucine benzyl ester p-toluenesulfonate
1738-77-8

L-leucine benzyl ester p-toluenesulfonate

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Fmoc-Met-Leu-OBzl ester

Fmoc-Met-Leu-OBzl ester

Conditions
ConditionsYield
Stage #1: L-leucine benzyl ester p-toluenesulfonate With triethylamine In dichloromethane at 20℃; for 0.5h;
Stage #2: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃;
93%
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

(9H-fluoren-9-yl)methyl (S)-(1-fluoro-4-(methylthio)-1-oxobutan-2-yl)carbamate
130859-02-8

(9H-fluoren-9-yl)methyl (S)-(1-fluoro-4-(methylthio)-1-oxobutan-2-yl)carbamate

Conditions
ConditionsYield
With tetramethylammonium trifluoromethanethiolate In dichloromethane at 20℃; for 0.0833333h;92%
With pyridine; trifluoro-[1,3,5]triazine In dichloromethane for 4h; Ambient temperature;80%
With pyridine; trifluoro-[1,3,5]triazine In dichloromethane at 20℃;74%
With pyridine; trifluoro-[1,3,5]triazine In dichloromethane for 2h;72%
L-leucine benzyl ester hydrochloride
2462-35-3

L-leucine benzyl ester hydrochloride

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Fmoc-Met-Leu-OBzl ester

Fmoc-Met-Leu-OBzl ester

Conditions
ConditionsYield
With C36H24B4N2O3 In toluene at 80℃; for 48h; Inert atmosphere; Molecular sieve;92%
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionic acid (benzhydryl-carbamoyl)-methyl ester; compound with trifluoro-acetic acid
119706-37-5

(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionic acid (benzhydryl-carbamoyl)-methyl ester; compound with trifluoro-acetic acid

Fmoc-Met-Leu-Phe-OBg
119706-25-1

Fmoc-Met-Leu-Phe-OBg

Conditions
ConditionsYield
With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In N,N-dimethyl-formamide for 0.5h; Ambient temperature;91%
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Ala-Ile-Pro-O-t-Bu

Ala-Ile-Pro-O-t-Bu

N-Fmoc-Met-Ala-Ile-Pro-t-Bu

N-Fmoc-Met-Ala-Ile-Pro-t-Bu

Conditions
ConditionsYield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Addition; Peptide-bond formation;91%
1,2,3-Benzotriazole
95-14-7

1,2,3-Benzotriazole

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

9H-fluoren-9-ylmethyl N-[(1S)-1-(1H-1,2,3-benzotriazol-1-ylcarbonyl)-3-(methylsulfanyl)propyl]carbamate
850232-62-1

9H-fluoren-9-ylmethyl N-[(1S)-1-(1H-1,2,3-benzotriazol-1-ylcarbonyl)-3-(methylsulfanyl)propyl]carbamate

Conditions
ConditionsYield
Stage #1: 1,2,3-Benzotriazole With thionyl chloride In tetrahydrofuran at 25℃; for 0.5h; Inert atmosphere;
Stage #2: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;
91%
Stage #1: 1,2,3-Benzotriazole With thionyl chloride In tetrahydrofuran at 35 - 40℃; for 0.333333h;
Stage #2: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine In tetrahydrofuran at 25℃; for 2h;
87%
Stage #1: 1,2,3-Benzotriazole With thionyl chloride In tetrahydrofuran at 40 - 50℃; for 0.333333h;
Stage #2: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine In tetrahydrofuran at 20℃; for 2h;
87%
With thionyl chloride In tetrahydrofuran at 20℃; for 2h;
curcumin
147556-16-9

curcumin

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

((1E,3Z,6E)-3-hydroxy-5-oxohepta-1,3,6-triene-1,7-diyl)bis(2-methoxy-4,1-phenylene) (2S,2'S)-bis(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylthio)butanoate)

((1E,3Z,6E)-3-hydroxy-5-oxohepta-1,3,6-triene-1,7-diyl)bis(2-methoxy-4,1-phenylene) (2S,2'S)-bis(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylthio)butanoate)

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - 0℃;91%
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Fmoc-methioninechloride
103321-54-6

Fmoc-methioninechloride

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane for 1h; Ambient temperature;90.3%
With thionyl chloride In dichloromethane for 24h; Ambient temperature;90%
With pyridine; thionyl chloride In dichloromethane Heating;
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Fmoc-Met-N(CH3)-OCH3

Fmoc-Met-N(CH3)-OCH3

Conditions
ConditionsYield
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1,8-diazabicyclo[5.4.0]undec-7-ene In ethyl acetate; acetonitrile at 0℃; for 0.166667h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In ethyl acetate; acetonitrile at 0℃; for 0.5h;
90%
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine With trichloroacetonitrile; triphenylphosphine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;
78%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine
Stage #1: N,O-dimethylhydroxylamine*hydrochloride; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In acetonitrile at 0℃; Inert atmosphere;
Stage #2: With N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 20℃; Inert atmosphere;
Fmoc-Leu-OH
35661-60-0

Fmoc-Leu-OH

N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
71989-28-1

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

NH2-RMLRF-OH

NH2-RMLRF-OH

Conditions
ConditionsYield
Stage #1: N-Fmoc L-Phe With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.666667h;
Stage #2: With N-ethyl-N,N-diisopropylamine In methanol; dichloromethane at 20℃; for 0.166667h;
Stage #3: Fmoc-Leu-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine Further stages;
90%

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