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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

nortriptyline

Cas:72-69-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

72-69-5 NORTRIPTYLINE

Cas:72-69-5

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-

Cas:72-69-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

NORTRIPTYLINE CAS:72-69-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

NORTRIPTYLINE CAS:72-69-5

Cas:72-69-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-

Cas:72-69-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-

Cas:72-69-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Nortriptyline

Cas:72-69-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

NORTRIPTYLINE

Cas:72-69-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Nortriptyline

Cas:72-69-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

NORTRIPTYLINE

Cas:72-69-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

nortriptyline

Cas:72-69-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

nortriptyline

Cas:72-69-5

Min.Order:0

Negotiable

Type:Other

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Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:API

99% up by HPLC NORTRIPTYLINE 72-69-5

Cas:72-69-5

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

NORTRIPTYLINE

Cas:72-69-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-

Cas:72-69-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Fandachem Co.,Ltd

NortriptylineAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Nortriptyline

Cas:72-69-5

Min.Order:0

Negotiable

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

nortriptyline

Cas:72-69-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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BOC Sciences

BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.Appearanc

nortriptyline

Cas:72-69-5

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

72-69-5

Cas:72-69-5

Min.Order:0

Negotiable

Type:Trading Company

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

NORTRIPTYLINE

Cas:72-69-5

Min.Order:0

Negotiable

Type:Trading Company

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Active Pharmaceutical Ingredients

Nortriptyline

Cas:72-69-5

Min.Order:0

Negotiable

Type:

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HENAN SUNLAKE ENTERPRISE CORPORATION

NORTRIPTYLINE

Cas:72-69-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei youze Biotechnology Co.,Ltd

1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment terms accepted (Btc;MoneyGram;WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery (3-10 DAYS fast deli

Nortriptyline CAS:72-69-5 the cheapest price

Cas:72-69-5

Min.Order:1 Kilogram

FOB Price: $10.0 / 13.0

Type:Trading Company

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Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

nortriptyline CAS NO.72-69-5

Cas:72-69-5

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-

Cas:72-69-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

AOPHARM

Transportation:by courier, Air or Sea

Nortriptyline

Cas:72-69-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Nanjing Raymon Biotech Co., Ltd.

nortriptyline Storage:Store in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/Pharmaceutical intermediates Transportation:By Sea,by Air,By courier like DHL or Fedx. Port:Shanghai/Shenzhen

nortriptyline

Cas:72-69-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Ruishun Trade Co.,Ltd

Supply top quality products with a reasonable price Application:api

72-69-5

Cas:72-69-5

Min.Order:0

Negotiable

Type:Trading Company

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Rajnikem Pharmaceuticals

Nortriptyline

Cas:72-69-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemical Co.Ltd

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-Appearance:Off white to slight yellow solid Storage:Stored in shaded, cool and dry places Package:1L 5L 10L 25L bottle Application:pharma intermediate Transportation:Handle

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-

Cas:72-69-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

amitriptyline hydrochloride
549-18-8

amitriptyline hydrochloride

A

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

B

10-Hydroxynortriptyline
1156-99-6

10-Hydroxynortriptyline

C

(Z)-10-Hydroxyamitriptyline
64520-05-4

(Z)-10-Hydroxyamitriptyline

Conditions
ConditionsYield
With glucose dehydrogenase; D-glucose; cytochrome P450BM3 F87A/H171L/Q307H/N319Y mutant; oxygen; β-nicotinamide adenine dinucleotide phosphate sodium salt In ethanol at 25℃; for 2h; pH=8.5; Enzymatic reaction;A 69%
B n/a
C n/a
N-methyl-4-(2-phenethylphenyl)but-3-yn-1-amine

N-methyl-4-(2-phenethylphenyl)but-3-yn-1-amine

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In dichloromethane at 0℃; for 0.166667h; Friedel-Crafts Alkylation; regioselective reaction;68%
5-<3-(N-Carbethoxy-N-methyl-amino)-propyliden>-10,11-dihydro-dibenzocyclohepten
16234-88-1

5-<3-(N-Carbethoxy-N-methyl-amino)-propyliden>-10,11-dihydro-dibenzocyclohepten

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
With potassium hydroxide In butan-1-ol at 120 - 125℃;
5-<3-(N-Methyl-p-toluolsulfonamido)-propyliden>-10,11-dihydro-dibenzocyclohepten
16235-12-4

5-<3-(N-Methyl-p-toluolsulfonamido)-propyliden>-10,11-dihydro-dibenzocyclohepten

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
With hydrogen bromide; acetic acid; phenol
5-<3-(N-Carbethoxy-N-methyl-amino>-propyl>-10,11-dihydro-dibenzocyclohepten-5-ol
16234-89-2

5-<3-(N-Carbethoxy-N-methyl-amino>-propyl>-10,11-dihydro-dibenzocyclohepten-5-ol

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
With hydrogen bromide In acetic acid Heating;
5-(3-bromo-1-propylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
3436-04-2

5-(3-bromo-1-propylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene

methylamine
74-89-5

methylamine

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
In benzene
In ethanol at 20℃; for 24h;
10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenzo[a,d]cyclohepten-5-ol
2939-66-4

10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenzo[a,d]cyclohepten-5-ol

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 15h; Heating; Yield given;
Amitriptyline
50-48-6

Amitriptyline

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
With oxygen; palladium on activated charcoal In methanol for 24h; Ambient temperature;
Multi-step reaction with 2 steps
1: benzene / Heating
2: KOH / butan-1-ol / 120 - 125 °C
View Scheme
Multi-step reaction with 2 steps
1: Py / Heating
2: HBr, AcOH, PhOH
View Scheme
With CYP2C19 Enzymatic reaction;
Multi-step reaction with 2 steps
1: triethylamine / 1,2-dichloro-ethane / 2 h / Reflux
2: 4 h / Reflux
View Scheme
Amitriptyline
50-48-6

Amitriptyline

A

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

B

(Z)-N,N-dimethyl-3-(10,11-dihydro-10-hydroxy-5H-dibenzocycloheptene)-Δ5,γ-propylamine
1159-82-6

(Z)-N,N-dimethyl-3-(10,11-dihydro-10-hydroxy-5H-dibenzocycloheptene)-Δ5,γ-propylamine

C

(-)-(E)-10-Hydroxy-Amitriptylline
64520-05-4, 129312-48-7, 129312-49-8

(-)-(E)-10-Hydroxy-Amitriptylline

Conditions
ConditionsYield
With glucose-6-phosphate dehydrogenase; Tris-HCl buffer; α-D-glucose 6-phosphate; liver microsomes of Wistar rats; NADPH; magnesium chloride In water at 37℃; Rate constant; Product distribution;
3-(5-Hydroxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-propionamide
115107-86-3

3-(5-Hydroxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-propionamide

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4 / tetrahydrofuran / 1.) reflux, 4 h, 2.) r.t., 15 h
2: p-TosOH / toluene / 15 h / Heating
View Scheme
3',4',10,11-Tetrahydro-spiro<5H-dibenzocyclohepten-5,5'(2'H)-furan>-2'-on
99082-15-2

3',4',10,11-Tetrahydro-spiro<5H-dibenzocyclohepten-5,5'(2'H)-furan>-2'-on

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol / 72 h / Ambient temperature
2: LiAlH4 / tetrahydrofuran / 1.) reflux, 4 h, 2.) r.t., 15 h
3: p-TosOH / toluene / 15 h / Heating
View Scheme
5-(3-bromo-1-propylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
3436-04-2

5-(3-bromo-1-propylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 170 °C
2: HBr, AcOH, PhOH
View Scheme
5-(3-dimethylaminopropyl)-10,11-dihydrodibenzo[a,d]cyclohepten-5-ol
1159-03-1

5-(3-dimethylaminopropyl)-10,11-dihydrodibenzo[a,d]cyclohepten-5-ol

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzene / Heating
2: aq. HBr / acetic acid / Heating
View Scheme
2-[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propoxy]-tetrahydro-pyran

2-[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propoxy]-tetrahydro-pyran

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aq. HBr / Heating
2: 170 °C
3: HBr, AcOH, PhOH
View Scheme
Multi-step reaction with 2 steps
1: aq. HBr / Heating
2: benzene
View Scheme
aminomethylfluorescein hydrochloride

aminomethylfluorescein hydrochloride

2-ethyl-5-phenylisoxazolium-3'-sulphonate
4156-16-5

2-ethyl-5-phenylisoxazolium-3'-sulphonate

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
With triethylamine; trifluoroacetic acid In dichloromethane; N,N-dimethyl-formamide
Amitriptyline
50-48-6

Amitriptyline

A

hydroxy-amitriptyline

hydroxy-amitriptyline

B

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

C

Desmethylnortriptyline
4444-42-2

Desmethylnortriptyline

D

N,Ndimethyl-3-(10,11-dihydro-10-oxo-5H-dibenzocycloheptene)-Δ5,γ-propylamine
37401-47-1

N,Ndimethyl-3-(10,11-dihydro-10-oxo-5H-dibenzocycloheptene)-Δ5,γ-propylamine

Conditions
ConditionsYield
With NADPH In water; dimethyl sulfoxide at 37℃; for 1h; Microbiological reaction;
3-(10,11-dihydro-5H-dibenzocyclohepten-5-ylidene)propionitrile
40443-02-5

3-(10,11-dihydro-5H-dibenzocyclohepten-5-ylidene)propionitrile

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran
2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h
2.2: 4 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.33 h / Inert atmosphere; Cooling with ice
2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
2.2: 4 h / 20 °C
View Scheme
Desmethylnortriptyline
4444-42-2

Desmethylnortriptyline

methyl iodide
74-88-4

methyl iodide

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Stage #1: Desmethylnortriptyline With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.333333h;
Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 20℃; for 4h;
Stage #1: Desmethylnortriptyline With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.333333h;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 4h;
5-ethyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol
55090-31-8

5-ethyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetyl chloride / 1.5 h / Reflux
2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux
3.1: acetone; water / 12 h / Reflux
4.1: lithium aluminium tetrahydride / tetrahydrofuran
5.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h
5.2: 4 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: acetyl chloride / 1.5 h / Reflux
2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux
3.1: acetone; water / 12 h / Reflux
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.33 h / Inert atmosphere; Cooling with ice
5.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
5.2: 4 h / 20 °C
View Scheme
5-Ethyliden-10,11-dihydro-5H-dibenzocycloheptan
28860-39-1

5-Ethyliden-10,11-dihydro-5H-dibenzocycloheptan

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux
2.1: acetone; water / 12 h / Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran
4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h
4.2: 4 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux
2.1: acetone; water / 12 h / Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.33 h / Inert atmosphere; Cooling with ice
4.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
4.2: 4 h / 20 °C
View Scheme
2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)ethyl bromide
13099-16-6

2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)ethyl bromide

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetone; water / 12 h / Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran
3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h
3.2: 4 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: acetone; water / 12 h / Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.33 h / Inert atmosphere; Cooling with ice
3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
3.2: 4 h / 20 °C
View Scheme
C19H20O3S

C19H20O3S

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol; water / 2 h / 50 °C
2: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C
View Scheme
1-Bromo-2-iodobenzene
583-55-1

1-Bromo-2-iodobenzene

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / acetonitrile / 22 h / 0 - 20 °C
2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 20 °C
3: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C
4: triethylamine / dichloromethane / 2.5 h / 0 °C
5: ethanol; water / 2 h / 50 °C
6: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C
View Scheme
1-bromo-2-(phenylethenyl)benzene
21375-88-2

1-bromo-2-(phenylethenyl)benzene

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 20 °C
2: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C
3: triethylamine / dichloromethane / 2.5 h / 0 °C
4: ethanol; water / 2 h / 50 °C
5: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C
View Scheme
1-(2-bromophenyl)-2-phenylethane
57918-64-6

1-(2-bromophenyl)-2-phenylethane

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C
2: triethylamine / dichloromethane / 2.5 h / 0 °C
3: ethanol; water / 2 h / 50 °C
4: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C
View Scheme
4-(2-phenethylphenyl)but-3-yn-1-ol

4-(2-phenethylphenyl)but-3-yn-1-ol

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 2.5 h / 0 °C
2: ethanol; water / 2 h / 50 °C
3: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C
View Scheme
phenylacetylene
536-74-3

phenylacetylene

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / acetonitrile / 22 h / 0 - 20 °C
2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 20 °C
3: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C
4: triethylamine / dichloromethane / 2.5 h / 0 °C
5: ethanol; water / 2 h / 50 °C
6: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C
View Scheme
10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one
1210-35-1

10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: diethyl ether / 1.25 h / 20 °C / Reflux
2.1: acetyl chloride / 1.5 h / Reflux
3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux
4.1: acetone; water / 12 h / Reflux
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.33 h / Inert atmosphere; Cooling with ice
6.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
6.2: 4 h / 20 °C
View Scheme
amitriptyline hydrochloride
549-18-8

amitriptyline hydrochloride

A

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

B

(Z)-10-Hydroxyamitriptyline
64520-05-4

(Z)-10-Hydroxyamitriptyline

Conditions
ConditionsYield
With glucose dehydrogenase; D-glucose; cytochrome P450BM3 R47L/Y51F/V78I/A191T/N239H/I259V/A276T/A330P/L353I mutant; oxygen; β-nicotinamide adenine dinucleotide phosphate sodium salt In ethanol at 25℃; for 2h; pH=8.5; Enzymatic reaction;A n/a
B 18.7 mg
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

carbon dioxide
1111-72-4

carbon dioxide

[N-13CH3]-amitriptyline

[N-13CH3]-amitriptyline

Conditions
ConditionsYield
With hydrogen; tris(acetylacetonato)ruthenium(III); lithium chloride; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 140℃; for 20h; Autoclave; Inert atmosphere;96%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

ethyl acrylate
140-88-5

ethyl acrylate

3-{[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-methyl-amino}-propionic acid ethyl ester

3-{[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-methyl-amino}-propionic acid ethyl ester

Conditions
ConditionsYield
In ethanol for 2h; Heating;95%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

trifluoroacetic acid
76-05-1

trifluoroacetic acid

3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methyl-N-(2,2,2-trifluoroethyl)propan-1-amine

3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methyl-N-(2,2,2-trifluoroethyl)propan-1-amine

Conditions
ConditionsYield
With potassium phosphate; 18-crown-6 ether; phenylsilane In tetrahydrofuran at 80℃; for 4h; Glovebox; Molecular sieve; Schlenk technique;94%
silver(I) trifluoromethoxide
1006904-72-8

silver(I) trifluoromethoxide

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

(3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl)(methyl)carbamic fluoride

(3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl)(methyl)carbamic fluoride

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 2h; Inert atmosphere;93%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Bromodiphenylmethane
776-74-9

Bromodiphenylmethane

N-benzhydryl-3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine

N-benzhydryl-3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine

Conditions
ConditionsYield
With triethylamine In acetonitrile at 100℃; for 12h; Inert atmosphere;91%
α-bromo-γ-butyrolactone
5061-21-2

α-bromo-γ-butyrolactone

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

3-[methyl(3-{tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14- hexaen-2-ylidene}propyl)amino]oxolan-2-one

3-[methyl(3-{tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14- hexaen-2-ylidene}propyl)amino]oxolan-2-one

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In acetonitrile at 0 - 20℃;89%
carbon dioxide
124-38-9

carbon dioxide

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

ethyl iodide
75-03-6

ethyl iodide

5-<3-(N-Carbethoxy-N-methyl-amino)-propyliden>-10,11-dihydro-dibenzocyclohepten
16234-88-1

5-<3-(N-Carbethoxy-N-methyl-amino)-propyliden>-10,11-dihydro-dibenzocyclohepten

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 20℃; chemoselective reaction;86%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

1-((3,5-difluorophenyl)sulfonyl)bicyclo[1.1.0]butane

1-((3,5-difluorophenyl)sulfonyl)bicyclo[1.1.0]butane

C23H27N

C23H27N

Conditions
ConditionsYield
Stage #1: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine; 1-((3,5-difluorophenyl)sulfonyl)bicyclo[1.1.0]butane In dimethyl sulfoxide at 20℃; for 24h; Sonication;
Stage #2: With magnesium In deuteromethanol
83%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

2-iodo-4,N-dimethyl-N-phenylethynylbenzenesulfonamide

2-iodo-4,N-dimethyl-N-phenylethynylbenzenesulfonamide

C35H34N2O2S

C35H34N2O2S

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In dimethyl sulfoxide at 70℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;76%
carbon dioxide
124-38-9

carbon dioxide

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

N-(3-(10,11-dihydro-5H-dibenso[a,d][7]annulen-5-ylidene)propyl)-N-methylformamide

N-(3-(10,11-dihydro-5H-dibenso[a,d][7]annulen-5-ylidene)propyl)-N-methylformamide

Conditions
ConditionsYield
With phenylsilane; tetrabutyl ammonium fluoride at 20℃; for 4h;70%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

2-bromo-N-(4-chlorobenzyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
1621341-90-9

2-bromo-N-(4-chlorobenzyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide

N-[(4-chlorophenyl)methyl]-4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-2-[methyl(3-{tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}propyl)amino]butanamide

N-[(4-chlorophenyl)methyl]-4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-2-[methyl(3-{tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}propyl)amino]butanamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 24h; Reflux;64%
carbon dioxide
124-38-9

carbon dioxide

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
With diphenylsilane; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene In N,N-dimethyl-formamide at 50℃; under 760.051 Torr; chemoselective reaction;63%
With hydrogen; tris(acetylacetonato)ruthenium(III); lithium chloride; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 140℃; for 24h; Autoclave; Inert atmosphere;81 %Chromat.
3-chlorothiophene-2-carboxylic acid
59337-89-2

3-chlorothiophene-2-carboxylic acid

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

3-chloro-N-[3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl]-N-methylthiophene-2-carboxamide
1067431-34-8

3-chloro-N-[3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl]-N-methylthiophene-2-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;56%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

1-oxyl-2,2,5,5-tetramethylpyrrolidinyl-3-carboxylic acid N-hydroxysuccinimide ester
58537-73-8

1-oxyl-2,2,5,5-tetramethylpyrrolidinyl-3-carboxylic acid N-hydroxysuccinimide ester

A

C28H35N2O2

C28H35N2O2

B

C32H40N3O5

C32H40N3O5

Conditions
ConditionsYield
In tetrahydrofuran 1) 4d, RT, 2) 50-60 deg C, 3 d;A 55%
B 29%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

2-cyclohepten-5-yliden)-propylamino>-1,4-naphthochinon

2-cyclohepten-5-yliden)-propylamino>-1,4-naphthochinon

Conditions
ConditionsYield
In dichloromethane for 1h; Ambient temperature; in the dark;54%
N-benzyl-2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanamide
16699-70-0

N-benzyl-2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanamide

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

N-benzyl-4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-2-[methyl(3-{tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}propyl)amino]butanamide

N-benzyl-4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-2-[methyl(3-{tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}propyl)amino]butanamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 24h; Reflux;52%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

2-Methyl-1,4-benzoquinone
553-97-9

2-Methyl-1,4-benzoquinone

A

5-Methyl-2-cyclohepten-5-yliden)-propylamino>-1,4-benzochinon
108141-74-8

5-Methyl-2-cyclohepten-5-yliden)-propylamino>-1,4-benzochinon

B

6-Methyl-2-cyclohepten-5-yliden)-propylamino>-1,4-benzochinon
108141-78-2

6-Methyl-2-cyclohepten-5-yliden)-propylamino>-1,4-benzochinon

Conditions
ConditionsYield
In dichloromethane for 24h; Ambient temperature;A 51%
B 34%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

6-O-trityl-D-glucopyranose
54325-28-9

6-O-trityl-D-glucopyranose

A

N-[6-O-trityl-D-glucopyranosyl]-N-methyl-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propanamine

N-[6-O-trityl-D-glucopyranosyl]-N-methyl-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propanamine

B

N-[6-O-trityl-β-D-glucopyranosyl]-N-methyl-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propanamine
1186033-19-1

N-[6-O-trityl-β-D-glucopyranosyl]-N-methyl-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propanamine

Conditions
ConditionsYield
In dichloromethane at 20℃; Inert atmosphere;A n/a
B 49%
2,3-Dichloro-1,4-naphthoquinone
117-80-6

2,3-Dichloro-1,4-naphthoquinone

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

3-Chlor-2-cyclohepten-5-yliden)-propylamino>-1,4-naphthochinon

3-Chlor-2-cyclohepten-5-yliden)-propylamino>-1,4-naphthochinon

Conditions
ConditionsYield
In dichloromethane for 2h;48%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

2-bromo-N-(2-chlorobenzyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
1621341-88-5

2-bromo-N-(2-chlorobenzyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide

N-[(2-chlorophenyl)methyl]-4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-2-[methyl(3-{tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}propyl)amino]butanamide

N-[(2-chlorophenyl)methyl]-4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-2-[methyl(3-{tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}propyl)amino]butanamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 24h; Reflux;47%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

2-bromo-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide
1621341-92-1

2-bromo-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide

N-[(4-fluorophenyl)methyl]-4-(1,3-dioxo-2,3-dihydro-1Hisoindol-2-yl)-2-[methyl(3-{tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}propyl)amino]butanamide

N-[(4-fluorophenyl)methyl]-4-(1,3-dioxo-2,3-dihydro-1Hisoindol-2-yl)-2-[methyl(3-{tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}propyl)amino]butanamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 24h; Reflux;47%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

2-bromo-4-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)butanamide
1621341-94-3

2-bromo-4-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)butanamide

4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-2-[methyl(3-{tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}propyl)amino]-N-[(4-methylphenyl)methyl]butanamide

4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-2-[methyl(3-{tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}propyl)amino]-N-[(4-methylphenyl)methyl]butanamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 24h; Reflux;45%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

N-Methyl-3-(10,11-dihydro-5H-dibenzocyclohepten-5-yliden)-propylamino-1,4-benzochinon

N-Methyl-3-(10,11-dihydro-5H-dibenzocyclohepten-5-yliden)-propylamino-1,4-benzochinon

2,5-Bis-cyclohepten-5-yliden)-propylamino>-1,4-benzochinon

2,5-Bis-cyclohepten-5-yliden)-propylamino>-1,4-benzochinon

Conditions
ConditionsYield
In dichloromethane Ambient temperature;44%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

2,3-Dibromo-1,4-naphthoquinone
13243-65-7

2,3-Dibromo-1,4-naphthoquinone

3-Brom-2-cyclohepten-5-yliden)-propylamino>-1,4-naphthochinon

3-Brom-2-cyclohepten-5-yliden)-propylamino>-1,4-naphthochinon

Conditions
ConditionsYield
In dichloromethane for 1h;42%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

1-(2-Chloroethyl)-4-methoxybenzene
18217-00-0

1-(2-Chloroethyl)-4-methoxybenzene

3-(5,6-dihydrodibenzo[2,1-b:1',2'-e][7]annulen-11-ylidene)-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amine

3-(5,6-dihydrodibenzo[2,1-b:1',2'-e][7]annulen-11-ylidene)-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amine

Conditions
ConditionsYield
Stage #1: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: 1-(2-Chloroethyl)-4-methoxybenzene With triisobutylaluminum In tetrahydrofuran; hexane; toluene for 48h; Reflux; Inert atmosphere;
31%
2-(3,4-dimethoxyphenyl)-ethylchloride
27160-08-3

2-(3,4-dimethoxyphenyl)-ethylchloride

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

3-(5,6-dihydrodibenzo[2,1-b:1',2'-e][7]annulen-11-ylidene)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropan-1-amine

3-(5,6-dihydrodibenzo[2,1-b:1',2'-e][7]annulen-11-ylidene)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropan-1-amine

Conditions
ConditionsYield
Stage #1: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: 2-(3,4-dimethoxyphenyl)-ethylchloride With triisobutylaluminum In tetrahydrofuran; hexane; toluene for 48h; Reflux; Inert atmosphere;
27%
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester
21085-72-3

1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

A

methyl 2-acetoxy-3,4-di-O-acetyl-D-arabino-hex-1-enopyranuronate
62346-09-2

methyl 2-acetoxy-3,4-di-O-acetyl-D-arabino-hex-1-enopyranuronate

B

C32H37NO9
1207167-91-6

C32H37NO9

Conditions
ConditionsYield
With sodium carbonate In dichloromethane; water; acetoneA n/a
B 26%

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