As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryNORTRIPTYLINE CAS:72-69-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:API
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inquiryJ&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryNortriptylineAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
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BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.Appearanc
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inquiryPrice, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right
United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat
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inquirynortriptyline Storage:Store in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/Pharmaceutical intermediates Transportation:By Sea,by Air,By courier like DHL or Fedx. Port:Shanghai/Shenzhen
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1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-Appearance:Off white to slight yellow solid Storage:Stored in shaded, cool and dry places Package:1L 5L 10L 25L bottle Application:pharma intermediate Transportation:Handle
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inquiryamitriptyline hydrochloride
A
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
B
10-Hydroxynortriptyline
C
(Z)-10-Hydroxyamitriptyline
Conditions | Yield |
---|---|
With glucose dehydrogenase; D-glucose; cytochrome P450BM3 F87A/H171L/Q307H/N319Y mutant; oxygen; β-nicotinamide adenine dinucleotide phosphate sodium salt In ethanol at 25℃; for 2h; pH=8.5; Enzymatic reaction; | A 69% B n/a C n/a |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In dichloromethane at 0℃; for 0.166667h; Friedel-Crafts Alkylation; regioselective reaction; | 68% |
5-<3-(N-Carbethoxy-N-methyl-amino)-propyliden>-10,11-dihydro-dibenzocyclohepten
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With potassium hydroxide In butan-1-ol at 120 - 125℃; |
5-<3-(N-Methyl-p-toluolsulfonamido)-propyliden>-10,11-dihydro-dibenzocyclohepten
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With hydrogen bromide; acetic acid; phenol |
5-<3-(N-Carbethoxy-N-methyl-amino>-propyl>-10,11-dihydro-dibenzocyclohepten-5-ol
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With hydrogen bromide In acetic acid Heating; |
5-(3-bromo-1-propylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
methylamine
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
In benzene | |
In ethanol at 20℃; for 24h; |
10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenzo[a,d]cyclohepten-5-ol
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 15h; Heating; Yield given; |
Amitriptyline
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With oxygen; palladium on activated charcoal In methanol for 24h; Ambient temperature; | |
Multi-step reaction with 2 steps 1: benzene / Heating 2: KOH / butan-1-ol / 120 - 125 °C View Scheme | |
Multi-step reaction with 2 steps 1: Py / Heating 2: HBr, AcOH, PhOH View Scheme | |
With CYP2C19 Enzymatic reaction; | |
Multi-step reaction with 2 steps 1: triethylamine / 1,2-dichloro-ethane / 2 h / Reflux 2: 4 h / Reflux View Scheme |
Amitriptyline
A
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
B
(Z)-N,N-dimethyl-3-(10,11-dihydro-10-hydroxy-5H-dibenzocycloheptene)-Δ5,γ-propylamine
C
(-)-(E)-10-Hydroxy-Amitriptylline
Conditions | Yield |
---|---|
With glucose-6-phosphate dehydrogenase; Tris-HCl buffer; α-D-glucose 6-phosphate; liver microsomes of Wistar rats; NADPH; magnesium chloride In water at 37℃; Rate constant; Product distribution; |
3-(5-Hydroxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-propionamide
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: LiAlH4 / tetrahydrofuran / 1.) reflux, 4 h, 2.) r.t., 15 h 2: p-TosOH / toluene / 15 h / Heating View Scheme |
3',4',10,11-Tetrahydro-spiro<5H-dibenzocyclohepten-5,5'(2'H)-furan>-2'-on
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethanol / 72 h / Ambient temperature 2: LiAlH4 / tetrahydrofuran / 1.) reflux, 4 h, 2.) r.t., 15 h 3: p-TosOH / toluene / 15 h / Heating View Scheme |
5-(3-bromo-1-propylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 170 °C 2: HBr, AcOH, PhOH View Scheme |
5-(3-dimethylaminopropyl)-10,11-dihydrodibenzo[a,d]cyclohepten-5-ol
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: benzene / Heating 2: aq. HBr / acetic acid / Heating View Scheme |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aq. HBr / Heating 2: 170 °C 3: HBr, AcOH, PhOH View Scheme | |
Multi-step reaction with 2 steps 1: aq. HBr / Heating 2: benzene View Scheme |
2-ethyl-5-phenylisoxazolium-3'-sulphonate
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With triethylamine; trifluoroacetic acid In dichloromethane; N,N-dimethyl-formamide |
Amitriptyline
B
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
C
Desmethylnortriptyline
D
N,Ndimethyl-3-(10,11-dihydro-10-oxo-5H-dibenzocycloheptene)-Δ5,γ-propylamine
Conditions | Yield |
---|---|
With NADPH In water; dimethyl sulfoxide at 37℃; for 1h; Microbiological reaction; |
3-(10,11-dihydro-5H-dibenzocyclohepten-5-ylidene)propionitrile
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran 2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h 2.2: 4 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.33 h / Inert atmosphere; Cooling with ice 2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C 2.2: 4 h / 20 °C View Scheme |
Desmethylnortriptyline
methyl iodide
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Stage #1: Desmethylnortriptyline With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.333333h; Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 20℃; for 4h; | |
Stage #1: Desmethylnortriptyline With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.333333h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 4h; |
5-ethyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: acetyl chloride / 1.5 h / Reflux 2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux 3.1: acetone; water / 12 h / Reflux 4.1: lithium aluminium tetrahydride / tetrahydrofuran 5.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h 5.2: 4 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: acetyl chloride / 1.5 h / Reflux 2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux 3.1: acetone; water / 12 h / Reflux 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.33 h / Inert atmosphere; Cooling with ice 5.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C 5.2: 4 h / 20 °C View Scheme |
5-Ethyliden-10,11-dihydro-5H-dibenzocycloheptan
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux 2.1: acetone; water / 12 h / Reflux 3.1: lithium aluminium tetrahydride / tetrahydrofuran 4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h 4.2: 4 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux 2.1: acetone; water / 12 h / Reflux 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.33 h / Inert atmosphere; Cooling with ice 4.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C 4.2: 4 h / 20 °C View Scheme |
2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)ethyl bromide
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: acetone; water / 12 h / Reflux 2.1: lithium aluminium tetrahydride / tetrahydrofuran 3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h 3.2: 4 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: acetone; water / 12 h / Reflux 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.33 h / Inert atmosphere; Cooling with ice 3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C 3.2: 4 h / 20 °C View Scheme |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol; water / 2 h / 50 °C 2: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C View Scheme |
1-Bromo-2-iodobenzene
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / acetonitrile / 22 h / 0 - 20 °C 2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 20 °C 3: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C 4: triethylamine / dichloromethane / 2.5 h / 0 °C 5: ethanol; water / 2 h / 50 °C 6: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C View Scheme |
1-bromo-2-(phenylethenyl)benzene
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 20 °C 2: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C 3: triethylamine / dichloromethane / 2.5 h / 0 °C 4: ethanol; water / 2 h / 50 °C 5: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C View Scheme |
1-(2-bromophenyl)-2-phenylethane
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C 2: triethylamine / dichloromethane / 2.5 h / 0 °C 3: ethanol; water / 2 h / 50 °C 4: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C View Scheme |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2.5 h / 0 °C 2: ethanol; water / 2 h / 50 °C 3: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C View Scheme |
phenylacetylene
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / acetonitrile / 22 h / 0 - 20 °C 2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 20 °C 3: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C 4: triethylamine / dichloromethane / 2.5 h / 0 °C 5: ethanol; water / 2 h / 50 °C 6: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C View Scheme |
10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: diethyl ether / 1.25 h / 20 °C / Reflux 2.1: acetyl chloride / 1.5 h / Reflux 3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux 4.1: acetone; water / 12 h / Reflux 5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.33 h / Inert atmosphere; Cooling with ice 6.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C 6.2: 4 h / 20 °C View Scheme |
amitriptyline hydrochloride
A
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
B
(Z)-10-Hydroxyamitriptyline
Conditions | Yield |
---|---|
With glucose dehydrogenase; D-glucose; cytochrome P450BM3 R47L/Y51F/V78I/A191T/N239H/I259V/A276T/A330P/L353I mutant; oxygen; β-nicotinamide adenine dinucleotide phosphate sodium salt In ethanol at 25℃; for 2h; pH=8.5; Enzymatic reaction; | A n/a B 18.7 mg |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
carbon dioxide
Conditions | Yield |
---|---|
With hydrogen; tris(acetylacetonato)ruthenium(III); lithium chloride; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 140℃; for 20h; Autoclave; Inert atmosphere; | 96% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
ethyl acrylate
Conditions | Yield |
---|---|
In ethanol for 2h; Heating; | 95% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
trifluoroacetic acid
Conditions | Yield |
---|---|
With potassium phosphate; 18-crown-6 ether; phenylsilane In tetrahydrofuran at 80℃; for 4h; Glovebox; Molecular sieve; Schlenk technique; | 94% |
silver(I) trifluoromethoxide
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 2h; Inert atmosphere; | 93% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Bromodiphenylmethane
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 100℃; for 12h; Inert atmosphere; | 91% |
α-bromo-γ-butyrolactone
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; potassium carbonate In acetonitrile at 0 - 20℃; | 89% |
carbon dioxide
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
ethyl iodide
5-<3-(N-Carbethoxy-N-methyl-amino)-propyliden>-10,11-dihydro-dibenzocyclohepten
Conditions | Yield |
---|---|
With caesium carbonate In dimethyl sulfoxide at 20℃; chemoselective reaction; | 86% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Stage #1: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine; 1-((3,5-difluorophenyl)sulfonyl)bicyclo[1.1.0]butane In dimethyl sulfoxide at 20℃; for 24h; Sonication; Stage #2: With magnesium In deuteromethanol | 83% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In dimethyl sulfoxide at 70℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube; | 76% |
carbon dioxide
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With phenylsilane; tetrabutyl ammonium fluoride at 20℃; for 4h; | 70% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
2-bromo-N-(4-chlorobenzyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 24h; Reflux; | 64% |
carbon dioxide
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Amitriptyline
Conditions | Yield |
---|---|
With diphenylsilane; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene In N,N-dimethyl-formamide at 50℃; under 760.051 Torr; chemoselective reaction; | 63% |
With hydrogen; tris(acetylacetonato)ruthenium(III); lithium chloride; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 140℃; for 24h; Autoclave; Inert atmosphere; | 81 %Chromat. |
3-chlorothiophene-2-carboxylic acid
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
3-chloro-N-[3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl]-N-methylthiophene-2-carboxamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; | 56% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
1-oxyl-2,2,5,5-tetramethylpyrrolidinyl-3-carboxylic acid N-hydroxysuccinimide ester
Conditions | Yield |
---|---|
In tetrahydrofuran 1) 4d, RT, 2) 50-60 deg C, 3 d; | A 55% B 29% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
[1,4]naphthoquinone
Conditions | Yield |
---|---|
In dichloromethane for 1h; Ambient temperature; in the dark; | 54% |
N-benzyl-2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanamide
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 24h; Reflux; | 52% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
2-Methyl-1,4-benzoquinone
A
5-Methyl-2-cyclohepten-5-yliden)-propylamino>-1,4-benzochinon
B
6-Methyl-2-cyclohepten-5-yliden)-propylamino>-1,4-benzochinon
Conditions | Yield |
---|---|
In dichloromethane for 24h; Ambient temperature; | A 51% B 34% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
6-O-trityl-D-glucopyranose
B
N-[6-O-trityl-β-D-glucopyranosyl]-N-methyl-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propanamine
Conditions | Yield |
---|---|
In dichloromethane at 20℃; Inert atmosphere; | A n/a B 49% |
2,3-Dichloro-1,4-naphthoquinone
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
In dichloromethane for 2h; | 48% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
2-bromo-N-(2-chlorobenzyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 24h; Reflux; | 47% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
2-bromo-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 24h; Reflux; | 47% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
2-bromo-4-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)butanamide
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 24h; Reflux; | 45% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
In dichloromethane Ambient temperature; | 44% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
2,3-Dibromo-1,4-naphthoquinone
Conditions | Yield |
---|---|
In dichloromethane for 1h; | 42% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
1-(2-Chloroethyl)-4-methoxybenzene
Conditions | Yield |
---|---|
Stage #1: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: 1-(2-Chloroethyl)-4-methoxybenzene With triisobutylaluminum In tetrahydrofuran; hexane; toluene for 48h; Reflux; Inert atmosphere; | 31% |
2-(3,4-dimethoxyphenyl)-ethylchloride
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
Stage #1: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: 2-(3,4-dimethoxyphenyl)-ethylchloride With triisobutylaluminum In tetrahydrofuran; hexane; toluene for 48h; Reflux; Inert atmosphere; | 27% |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester
A
methyl 2-acetoxy-3,4-di-O-acetyl-D-arabino-hex-1-enopyranuronate
B
C32H37NO9
Conditions | Yield |
---|---|
With sodium carbonate In dichloromethane; water; acetone | A n/a B 26% |
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