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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Amitriptyline Manufacturer/High quality/Best price/In stock

Cas:50-48-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Amitriptyline

Cas:50-48-6

Min.Order:1

Negotiable

Type:Other

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Amitriptyline

Cas:50-48-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Amitriptyline (base and/or unspecified salts)

Cas:50-48-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Amitriptyline CAS:50-48-6

Cas:50-48-6

Min.Order:1 Metric Ton

FOB Price: $38.0 / 59.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

50-48-6 Amitriptyline

Cas:50-48-6

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:Central Nervous System Drug; Tricyclic and Related Antidepressant Transportation:By sea or by air Port:Qingdao Port

Amitriptyline

Cas:50-48-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-

Cas:50-48-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-

Cas:50-48-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Amitriptyline

Cas:50-48-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Amitriptyline

Cas:50-48-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Amitriptyline cas 50-48-6 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control syste

Amitriptyline cas 50-48-6

Cas:50-48-6

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-

Cas:50-48-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates Transportation:as p

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-

Cas:50-48-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Amitriptyline

Cas:50-48-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

1. DMF is available. 2. GMP is available 3. Under registerring in Japan and Korea Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fin

Amitriptyline

Cas:50-48-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Amitriptyline

Cas:50-48-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualified

High Quality 99% Amitriptyline 50-48-6 Manufacturer

Cas:50-48-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Amitriptyline

Cas:50-48-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Shenzhen Foris Technology Co. LTD

high purity lowest price Custom synthesis is our core business. We have a first-class R & D team, composed with decades of experience in the field of organic synthesis industry and academic leadership, which is composed of master and doctor of

Amitriptyline 50-48-6

Cas:50-48-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

Amitriptyline

Cas:50-48-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

amitriptyline

Cas:50-48-6

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Amitriptyline

Cas:50-48-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:API

99% up by HPLC Amitriptyline 50-48-6

Cas:50-48-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.Appearanc

Amitriptyline

Cas:50-48-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine

Cas:50-48-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Amitriptyline CAS No.50-48-6

Cas:50-48-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Amitriptyline cas 50-48-6Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Amitriptyline cas 50-48-6

Cas:50-48-6

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Amitriptyline

Cas:50-48-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

Amitriptyline 50-48-6

Cas:50-48-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

Amitriptyline N-oxide
4317-14-0

Amitriptyline N-oxide

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
With sodium tetrahydroborate In water at 50 - 60℃; chemoselective reaction;98%
formaldehyd
50-00-0

formaldehyd

Desmethylnortriptyline
4444-42-2

Desmethylnortriptyline

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
With formic acid; triethylamine In water; tert-butyl alcohol at 100℃; for 14h;89%
5-(3-dimethylaminopropyl)-10,11-dihydrodibenzo[a,d]cyclohepten-5-ol
1159-03-1

5-(3-dimethylaminopropyl)-10,11-dihydrodibenzo[a,d]cyclohepten-5-ol

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
In ethanol at 200℃; under 82508.3 Torr; for 0.01h; Solvent; Temperature; Flow reactor;78%
carbon dioxide
124-38-9

carbon dioxide

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
With diphenylsilane; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene In N,N-dimethyl-formamide at 50℃; under 760.051 Torr; chemoselective reaction;63%
With hydrogen; tris(acetylacetonato)ruthenium(III); lithium chloride; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 140℃; for 24h; Autoclave; Inert atmosphere;81 %Chromat.
N,N-dimethyl-4-(2-phenethylphenyl)but-3-yn-1-amine

N,N-dimethyl-4-(2-phenethylphenyl)but-3-yn-1-amine

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In dichloromethane at 0℃; for 0.166667h; Friedel-Crafts Alkylation; regioselective reaction;56%
1-Bromo-2-bromomethyl-benzene
3433-80-5

1-Bromo-2-bromomethyl-benzene

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: n-butyllithium; carbon dioxide / tetrahydrofuran; hexane / -50 - 20 °C / 3878.71 Torr / Flow reactor
2: methanol / tetrahydrofuran; toluene / 20 °C / Flow reactor
3: ethanol / 0.01 h / 200 °C / 82508.3 Torr / Flow reactor
View Scheme
Multi-step reaction with 3 steps
1: n-butyllithium; carbon dioxide / tetrahydrofuran; hexane / -50 - 20 °C / Flow reactor
2: methanol / tetrahydrofuran; toluene / 20 °C / Flow reactor
3: ethanol / 0.01 h / 200 °C / 82508.3 Torr / Flow reactor
View Scheme
10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one
1210-35-1

10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanol / tetrahydrofuran; toluene / 20 °C / Flow reactor
2: ethanol / 0.01 h / 200 °C / 82508.3 Torr / Flow reactor
View Scheme
formic acid
64-18-6

formic acid

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
With platinum(0)-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex; 1,3-bis-(diphenylphosphino)propane; phenylsilane In dibutyl ether at 60℃; for 18h; Schlenk technique; Inert atmosphere;94 %Chromat.
C19H20O3S

C19H20O3S

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol; water / 2 h / 50 °C
2: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C
View Scheme
1-Bromo-2-iodobenzene
583-55-1

1-Bromo-2-iodobenzene

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / acetonitrile / 22 h / 0 - 20 °C
2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 20 °C
3: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C
4: triethylamine / dichloromethane / 2.5 h / 0 °C
5: ethanol; water / 2 h / 50 °C
6: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C
View Scheme
1-bromo-2-(phenylethenyl)benzene
21375-88-2

1-bromo-2-(phenylethenyl)benzene

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 20 °C
2: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C
3: triethylamine / dichloromethane / 2.5 h / 0 °C
4: ethanol; water / 2 h / 50 °C
5: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C
View Scheme
1-(2-bromophenyl)-2-phenylethane
57918-64-6

1-(2-bromophenyl)-2-phenylethane

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C
2: triethylamine / dichloromethane / 2.5 h / 0 °C
3: ethanol; water / 2 h / 50 °C
4: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C
View Scheme
4-(2-phenethylphenyl)but-3-yn-1-ol

4-(2-phenethylphenyl)but-3-yn-1-ol

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 2.5 h / 0 °C
2: ethanol; water / 2 h / 50 °C
3: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C
View Scheme
phenylacetylene
536-74-3

phenylacetylene

Amitriptyline
50-48-6

Amitriptyline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / acetonitrile / 22 h / 0 - 20 °C
2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 20 °C
3: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C
4: triethylamine / dichloromethane / 2.5 h / 0 °C
5: ethanol; water / 2 h / 50 °C
6: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C
View Scheme
Amitriptyline
50-48-6

Amitriptyline

N-(3-(10,11-dihydro-5H-dibenso[a,d][7]annulen-5-ylidene)propyl)-N-methylformamide

N-(3-(10,11-dihydro-5H-dibenso[a,d][7]annulen-5-ylidene)propyl)-N-methylformamide

Conditions
ConditionsYield
With 2,4,4-trimethyl oxazoline; [2,2]bipyridinyl; C10H16NO; copper(II) bis(trifluoromethanesulfonate); copper(l) chloride In acetonitrile at 20℃; for 24h;94%
Chloromethyl methacrylate
27550-73-8

Chloromethyl methacrylate

Amitriptyline
50-48-6

Amitriptyline

[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-(2-methyl-acryloyloxymethyl)-ammonium; chloride
76637-17-7

[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-(2-methyl-acryloyloxymethyl)-ammonium; chloride

Conditions
ConditionsYield
In chloroform87%
Amitriptyline
50-48-6

Amitriptyline

3-(10,11-Dihydro-5-fluoro-5H-dibenzocyclohepten-5-yl)-3-fluoro-1-N,N-dimethylpropanamine
73037-99-7

3-(10,11-Dihydro-5-fluoro-5H-dibenzocyclohepten-5-yl)-3-fluoro-1-N,N-dimethylpropanamine

Conditions
ConditionsYield
With pyridinium polyhydrogenfluoride; dimethyl 2,2'-((2-iodo-5-(methoxycarbonyl)-1,3-phenylene)bis(oxy))diacetate; 3-chloro-benzenecarboperoxoic acid at 20℃; for 12h; Sealed tube;41%
With hypofluorous acid trifluoromethyl ester In dichloromethane at -50℃;5%
Amitriptyline
50-48-6

Amitriptyline

1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester
21085-72-3

1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-[3-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-ammonium; chloride
86492-47-9

((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-[3-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-ammonium; chloride

Conditions
ConditionsYield
With XAD-2 ion-exchange resin; sodium hydrogencarbonate In water; benzene for 72h; Ambient temperature;36%
potassium cyanide

potassium cyanide

Amitriptyline
50-48-6

Amitriptyline

2-((3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl)(methyl)amino)acetonitrile

2-((3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl)(methyl)amino)acetonitrile

Conditions
ConditionsYield
With 2-Picolinic acid; iron(III) chloride; tert-Butyl peroxybenzoate; 18-crown-6 ether In acetonitrile at 50℃; for 48h;35%
bromocyane
506-68-3

bromocyane

Amitriptyline
50-48-6

Amitriptyline

5-(3-N-Cyano-N-methylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
17684-48-9

5-(3-N-Cyano-N-methylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene

Amitriptyline
50-48-6

Amitriptyline

5-(2-propenylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
24755-73-5

5-(2-propenylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene

Conditions
ConditionsYield
(i) MeI, (ii) aq. NaOH; Multistep reaction;
Amitriptyline
50-48-6

Amitriptyline

5-<3-(N-Sulfonato-N,N-dimethyl-ammonio)-propyliden>-10,11-dihydro-dibenzocyclohepten
16234-91-6

5-<3-(N-Sulfonato-N,N-dimethyl-ammonio)-propyliden>-10,11-dihydro-dibenzocyclohepten

Conditions
ConditionsYield
With ethyl chlorosulfate In benzene Heating;
Amitriptyline
50-48-6

Amitriptyline

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

5-<3-(N-Carbethoxy-N-methyl-amino)-propyliden>-10,11-dihydro-dibenzocyclohepten
16234-88-1

5-<3-(N-Carbethoxy-N-methyl-amino)-propyliden>-10,11-dihydro-dibenzocyclohepten

Conditions
ConditionsYield
In benzene Heating;
Amitriptyline
50-48-6

Amitriptyline

acetic anhydride
108-24-7

acetic anhydride

N-acetylnortriptyline
16234-90-5

N-acetylnortriptyline

Conditions
ConditionsYield
With aluminium trichloride Heating;
Amitriptyline
50-48-6

Amitriptyline

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

5-<3-(N-Methyl-p-toluolsulfonamido)-propyliden>-10,11-dihydro-dibenzocyclohepten
16235-12-4

5-<3-(N-Methyl-p-toluolsulfonamido)-propyliden>-10,11-dihydro-dibenzocyclohepten

Conditions
ConditionsYield
With pyridine Heating;
Amitriptyline
50-48-6

Amitriptyline

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Conditions
ConditionsYield
With oxygen; palladium on activated charcoal In methanol for 24h; Ambient temperature;
Multi-step reaction with 2 steps
1: benzene / Heating
2: KOH / butan-1-ol / 120 - 125 °C
View Scheme
Multi-step reaction with 2 steps
1: Py / Heating
2: HBr, AcOH, PhOH
View Scheme
With CYP2C19 Enzymatic reaction;
Multi-step reaction with 2 steps
1: triethylamine / 1,2-dichloro-ethane / 2 h / Reflux
2: 4 h / Reflux
View Scheme
Amitriptyline
50-48-6

Amitriptyline

A

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

B

(Z)-N,N-dimethyl-3-(10,11-dihydro-10-hydroxy-5H-dibenzocycloheptene)-Δ5,γ-propylamine
1159-82-6

(Z)-N,N-dimethyl-3-(10,11-dihydro-10-hydroxy-5H-dibenzocycloheptene)-Δ5,γ-propylamine

C

(-)-(E)-10-Hydroxy-Amitriptylline
64520-05-4, 129312-48-7, 129312-49-8

(-)-(E)-10-Hydroxy-Amitriptylline

Conditions
ConditionsYield
With glucose-6-phosphate dehydrogenase; Tris-HCl buffer; α-D-glucose 6-phosphate; liver microsomes of Wistar rats; NADPH; magnesium chloride In water at 37℃; Rate constant; Product distribution;
Amitriptyline
50-48-6

Amitriptyline

Desmethylnortriptyline
4444-42-2

Desmethylnortriptyline

Conditions
ConditionsYield
With cDNA-expressed human cytochrome P450 (CYP) 1A2 enzyme In water at 37℃; for 0.25h; pH=7.4; Enzyme kinetics; Further Variations:; Reagents; demethylation; Enzymatic reaction;
Multi-step reaction with 2 steps
1: CYP2C19 / Enzymatic reaction
2: CYP2C19 / Enzymatic reaction
View Scheme
Amitriptyline
50-48-6

Amitriptyline

(-)-(E)-10-Hydroxy-Amitriptylline
64520-05-4, 129312-48-7, 129312-49-8

(-)-(E)-10-Hydroxy-Amitriptylline

Conditions
ConditionsYield
With cDNA-expressed human cytochrome P450 (CYP) 2D6 enzyme In water at 37℃; for 0.25h; pH=7.4; Enzyme kinetics; Further Variations:; Reagents; hydroxylation; Enzymatic reaction;
Amitriptyline
50-48-6

Amitriptyline

Methadone
76-99-3

Methadone

(R,S)-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine

(R,S)-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine

Conditions
ConditionsYield
With human CYP2D6 In phosphate buffer at 37℃; for 0.333333h; pH=7.4; Enzyme kinetics;
With human CYP3A4 In phosphate buffer at 37℃; for 0.333333h; pH=7.4; Enzyme kinetics;
Amitriptyline
50-48-6

Amitriptyline

Amitriptyline N-oxide
4317-14-0

Amitriptyline N-oxide

Conditions
ConditionsYield
With dihydrogen peroxide In methanol for 168h;2.2 g
Amitriptyline
50-48-6

Amitriptyline

A

hydroxy-amitriptyline

hydroxy-amitriptyline

B

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
72-69-5

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

C

Desmethylnortriptyline
4444-42-2

Desmethylnortriptyline

D

N,Ndimethyl-3-(10,11-dihydro-10-oxo-5H-dibenzocycloheptene)-Δ5,γ-propylamine
37401-47-1

N,Ndimethyl-3-(10,11-dihydro-10-oxo-5H-dibenzocycloheptene)-Δ5,γ-propylamine

Conditions
ConditionsYield
With NADPH In water; dimethyl sulfoxide at 37℃; for 1h; Microbiological reaction;
Amitriptyline
50-48-6

Amitriptyline

amitriptyline hydrochloride
549-18-8

amitriptyline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In isopropyl alcohol at 20℃; Flow reactor;

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