As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryAppearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:Central Nervous System Drug; Tricyclic and Related Antidepressant Transportation:By sea or by air Port:Qingdao Port
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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Amitriptyline cas 50-48-6 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control syste
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquirysuperior quality Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates Transportation:as p
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
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high purity lowest price Custom synthesis is our core business. We have a first-class R & D team, composed with decades of experience in the field of organic synthesis industry and academic leadership, which is composed of master and doctor of
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inquiryISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai
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inquiryAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
Amitriptyline cas 50-48-6Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China
Conditions | Yield |
---|---|
With sodium tetrahydroborate In water at 50 - 60℃; chemoselective reaction; | 98% |
Conditions | Yield |
---|---|
With formic acid; triethylamine In water; tert-butyl alcohol at 100℃; for 14h; | 89% |
Conditions | Yield |
---|---|
In ethanol at 200℃; under 82508.3 Torr; for 0.01h; Solvent; Temperature; Flow reactor; | 78% |
carbon dioxide
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Amitriptyline
Conditions | Yield |
---|---|
With diphenylsilane; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene In N,N-dimethyl-formamide at 50℃; under 760.051 Torr; chemoselective reaction; | 63% |
With hydrogen; tris(acetylacetonato)ruthenium(III); lithium chloride; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 140℃; for 24h; Autoclave; Inert atmosphere; | 81 %Chromat. |
Amitriptyline
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In dichloromethane at 0℃; for 0.166667h; Friedel-Crafts Alkylation; regioselective reaction; | 56% |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: n-butyllithium; carbon dioxide / tetrahydrofuran; hexane / -50 - 20 °C / 3878.71 Torr / Flow reactor 2: methanol / tetrahydrofuran; toluene / 20 °C / Flow reactor 3: ethanol / 0.01 h / 200 °C / 82508.3 Torr / Flow reactor View Scheme | |
Multi-step reaction with 3 steps 1: n-butyllithium; carbon dioxide / tetrahydrofuran; hexane / -50 - 20 °C / Flow reactor 2: methanol / tetrahydrofuran; toluene / 20 °C / Flow reactor 3: ethanol / 0.01 h / 200 °C / 82508.3 Torr / Flow reactor View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: methanol / tetrahydrofuran; toluene / 20 °C / Flow reactor 2: ethanol / 0.01 h / 200 °C / 82508.3 Torr / Flow reactor View Scheme |
formic acid
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Amitriptyline
Conditions | Yield |
---|---|
With platinum(0)-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex; 1,3-bis-(diphenylphosphino)propane; phenylsilane In dibutyl ether at 60℃; for 18h; Schlenk technique; Inert atmosphere; | 94 %Chromat. |
Amitriptyline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol; water / 2 h / 50 °C 2: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / acetonitrile / 22 h / 0 - 20 °C 2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 20 °C 3: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C 4: triethylamine / dichloromethane / 2.5 h / 0 °C 5: ethanol; water / 2 h / 50 °C 6: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C View Scheme |
1-bromo-2-(phenylethenyl)benzene
Amitriptyline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 20 °C 2: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C 3: triethylamine / dichloromethane / 2.5 h / 0 °C 4: ethanol; water / 2 h / 50 °C 5: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C View Scheme |
1-(2-bromophenyl)-2-phenylethane
Amitriptyline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C 2: triethylamine / dichloromethane / 2.5 h / 0 °C 3: ethanol; water / 2 h / 50 °C 4: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C View Scheme |
Amitriptyline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2.5 h / 0 °C 2: ethanol; water / 2 h / 50 °C 3: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / acetonitrile / 22 h / 0 - 20 °C 2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 20 °C 3: caesium carbonate; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / acetonitrile / 6.5 h / 60 °C 4: triethylamine / dichloromethane / 2.5 h / 0 °C 5: ethanol; water / 2 h / 50 °C 6: trifluorormethanesulfonic acid / dichloromethane / 0.17 h / 0 °C View Scheme |
Amitriptyline
Conditions | Yield |
---|---|
With 2,4,4-trimethyl oxazoline; [2,2]bipyridinyl; C10H16NO; copper(II) bis(trifluoromethanesulfonate); copper(l) chloride In acetonitrile at 20℃; for 24h; | 94% |
Chloromethyl methacrylate
Amitriptyline
[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-(2-methyl-acryloyloxymethyl)-ammonium; chloride
Conditions | Yield |
---|---|
In chloroform | 87% |
Amitriptyline
3-(10,11-Dihydro-5-fluoro-5H-dibenzocyclohepten-5-yl)-3-fluoro-1-N,N-dimethylpropanamine
Conditions | Yield |
---|---|
With pyridinium polyhydrogenfluoride; dimethyl 2,2'-((2-iodo-5-(methoxycarbonyl)-1,3-phenylene)bis(oxy))diacetate; 3-chloro-benzenecarboperoxoic acid at 20℃; for 12h; Sealed tube; | 41% |
With hypofluorous acid trifluoromethyl ester In dichloromethane at -50℃; | 5% |
Amitriptyline
1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester
((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-[3-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-ammonium; chloride
Conditions | Yield |
---|---|
With XAD-2 ion-exchange resin; sodium hydrogencarbonate In water; benzene for 72h; Ambient temperature; | 36% |
Amitriptyline
Conditions | Yield |
---|---|
With 2-Picolinic acid; iron(III) chloride; tert-Butyl peroxybenzoate; 18-crown-6 ether In acetonitrile at 50℃; for 48h; | 35% |
bromocyane
Amitriptyline
5-(3-N-Cyano-N-methylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
Amitriptyline
5-(2-propenylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
Conditions | Yield |
---|---|
(i) MeI, (ii) aq. NaOH; Multistep reaction; |
Amitriptyline
5-<3-(N-Sulfonato-N,N-dimethyl-ammonio)-propyliden>-10,11-dihydro-dibenzocyclohepten
Conditions | Yield |
---|---|
With ethyl chlorosulfate In benzene Heating; |
Amitriptyline
chloroformic acid ethyl ester
5-<3-(N-Carbethoxy-N-methyl-amino)-propyliden>-10,11-dihydro-dibenzocyclohepten
Conditions | Yield |
---|---|
In benzene Heating; |
Conditions | Yield |
---|---|
With aluminium trichloride Heating; |
Amitriptyline
p-toluenesulfonyl chloride
5-<3-(N-Methyl-p-toluolsulfonamido)-propyliden>-10,11-dihydro-dibenzocyclohepten
Conditions | Yield |
---|---|
With pyridine Heating; |
Amitriptyline
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Conditions | Yield |
---|---|
With oxygen; palladium on activated charcoal In methanol for 24h; Ambient temperature; | |
Multi-step reaction with 2 steps 1: benzene / Heating 2: KOH / butan-1-ol / 120 - 125 °C View Scheme | |
Multi-step reaction with 2 steps 1: Py / Heating 2: HBr, AcOH, PhOH View Scheme | |
With CYP2C19 Enzymatic reaction; | |
Multi-step reaction with 2 steps 1: triethylamine / 1,2-dichloro-ethane / 2 h / Reflux 2: 4 h / Reflux View Scheme |
Amitriptyline
A
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
B
(Z)-N,N-dimethyl-3-(10,11-dihydro-10-hydroxy-5H-dibenzocycloheptene)-Δ5,γ-propylamine
C
(-)-(E)-10-Hydroxy-Amitriptylline
Conditions | Yield |
---|---|
With glucose-6-phosphate dehydrogenase; Tris-HCl buffer; α-D-glucose 6-phosphate; liver microsomes of Wistar rats; NADPH; magnesium chloride In water at 37℃; Rate constant; Product distribution; |
Conditions | Yield |
---|---|
With cDNA-expressed human cytochrome P450 (CYP) 1A2 enzyme In water at 37℃; for 0.25h; pH=7.4; Enzyme kinetics; Further Variations:; Reagents; demethylation; Enzymatic reaction; | |
Multi-step reaction with 2 steps 1: CYP2C19 / Enzymatic reaction 2: CYP2C19 / Enzymatic reaction View Scheme |
Amitriptyline
(-)-(E)-10-Hydroxy-Amitriptylline
Conditions | Yield |
---|---|
With cDNA-expressed human cytochrome P450 (CYP) 2D6 enzyme In water at 37℃; for 0.25h; pH=7.4; Enzyme kinetics; Further Variations:; Reagents; hydroxylation; Enzymatic reaction; |
Conditions | Yield |
---|---|
With human CYP2D6 In phosphate buffer at 37℃; for 0.333333h; pH=7.4; Enzyme kinetics; | |
With human CYP3A4 In phosphate buffer at 37℃; for 0.333333h; pH=7.4; Enzyme kinetics; |
Conditions | Yield |
---|---|
With dihydrogen peroxide In methanol for 168h; | 2.2 g |
Amitriptyline
B
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
C
Desmethylnortriptyline
D
N,Ndimethyl-3-(10,11-dihydro-10-oxo-5H-dibenzocycloheptene)-Δ5,γ-propylamine
Conditions | Yield |
---|---|
With NADPH In water; dimethyl sulfoxide at 37℃; for 1h; Microbiological reaction; |
Conditions | Yield |
---|---|
With hydrogenchloride In isopropyl alcohol at 20℃; Flow reactor; |
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