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Synthetic route

[2-(2,6-dichloroanilino)phenyl]acetic acid
15307-86-5

[2-(2,6-dichloroanilino)phenyl]acetic acid

O-desmethyltramadol
73986-53-5

O-desmethyltramadol

O-desmethyl-tramadol-diclofenac

O-desmethyl-tramadol-diclofenac

Conditions
ConditionsYield
In isopropyl alcohol at 20℃; Product distribution / selectivity;100%
O-desmethyltramadol
73986-53-5

O-desmethyltramadol

(S)-ibuprofen
51146-56-6

(S)-ibuprofen

O-desmethyl-tramadol-(S)-ibuprofen

O-desmethyl-tramadol-(S)-ibuprofen

Conditions
ConditionsYield
In toluene at 20℃; for 3h;91%
3-acetyl-2-hydroxybenzoic acid
67127-78-0

3-acetyl-2-hydroxybenzoic acid

O-desmethyltramadol
73986-53-5

O-desmethyltramadol

O-desmethyl-tramadol-acetylsalicylic acid

O-desmethyl-tramadol-acetylsalicylic acid

Conditions
ConditionsYield
In chloroform at 20℃; Product distribution / selectivity;88%
O-desmethyltramadol
73986-53-5

O-desmethyltramadol

triflusal
322-79-2

triflusal

O-desmethyl-tramadol-triflusal

O-desmethyl-tramadol-triflusal

Conditions
ConditionsYield
In ethyl acetate at 0 - 20℃; for 0.666667h; Product distribution / selectivity; Cooling with ice;77%
O-desmethyltramadol
73986-53-5

O-desmethyltramadol

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

O-desmethyl-tramadol-(S)-naproxen

O-desmethyl-tramadol-(S)-naproxen

Conditions
ConditionsYield
In chloroform Product distribution / selectivity; Heating;66%
fluorobiprofen
5104-49-4

fluorobiprofen

O-desmethyltramadol
73986-53-5

O-desmethyltramadol

O-desmethyl-tramadol-flurbiprofen

O-desmethyl-tramadol-flurbiprofen

Conditions
ConditionsYield
In acetic acid butyl ester Product distribution / selectivity;65%
N-Boc-gabapentin
227626-60-0

N-Boc-gabapentin

O-desmethyltramadol
73986-53-5

O-desmethyltramadol

(1R2R,1S2S)-3-(2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenyl 2-(1-((tert-butoxycarbonylamino)methyl)cyclohexyl)acetate
1345016-64-9

(1R2R,1S2S)-3-(2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenyl 2-(1-((tert-butoxycarbonylamino)methyl)cyclohexyl)acetate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h;44%
Carbonyldiimidazole
64269-79-0

Carbonyldiimidazole

ibuprofen
15687-27-1

ibuprofen

O-desmethyltramadol
73986-53-5

O-desmethyltramadol

3-(2-dimethylaminomethyl-1-hydroxy-cyclohexyl)-phenyl 2-(4-isobutyl-phenyl)-propionate
269079-66-5

3-(2-dimethylaminomethyl-1-hydroxy-cyclohexyl)-phenyl 2-(4-isobutyl-phenyl)-propionate

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; dichloromethane; water; mineral oil
With sodium hydroxide In tetrahydrofuran; dichloromethane; water; mineral oil

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