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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

4-Bromo-3,5-dimethyl-benzonitrile

Cas:75344-77-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white crystalline powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

1-(2-Chloro-ethyl)-4-isopropyl-piperazinedihydrochloride

Cas:75344-77-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Bromo-3,5-dimethylbenzonitrile

Cas:75344-77-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Bromo-3,5-dimethyl benzonitrile 75344-77-3

Cas:75344-77-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 4-BROMO-3,5-DIMETHYL-BENZONITRILE CAS: 75344-77-3 MF: C9H8BrN MW: 210.07 EINECS: 676-077-5 Product Categories: Mol File: 75344-77-3.mol 4-BROMO-3,5-DIMETHYL-BENZONITRILE Structure 4-BROMO-3,5-DIMETHYL-BENZONITRILE

3,5-Dimethyl-4-bromobenzonitrile

Cas:75344-77-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

4-BROMO-3,5-DIMETHYL-BENZONITRILE CAS:75344-77-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit

4-BROMO-3,5-DIMETHYL-BENZONITRILE CAS:75344-77-3

Cas:75344-77-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Bromo-3,5-dimethyl benzonitrile

Cas:75344-77-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:75344-77-3

Cas:75344-77-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

4-BROMO-3,5-DIMETHYL-BENZONITRILE

Cas:75344-77-3

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

4-Bromo-3,5-dimethylbenzonitrile

Cas:75344-77-3

Min.Order:1 Gram

FOB Price: $187.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Bromo-3,5-dimethyl-benzonitrile

Cas:75344-77-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-BROMO-3,5-DIMETHYL-BENZONITRILE

Cas:75344-77-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-BROMO-3,5-DIMETHYL-BENZONITRILE

Cas:75344-77-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-Bromo-3,5-dimethylbenzonitrile

Cas:75344-77-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in

4-Bromo-3,5-dimethylbenzonitrile

Cas:75344-77-3

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-BROMO-3,5-DIMETHYL-BENZONITRILE

Cas:75344-77-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

4-Bromo-3,5-dimethylbenzonitrile

Cas:75344-77-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-BROMO-3,5-DIMETHYL-BENZONITRILE

Cas:75344-77-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4-BROMO-3,5-DIMETHYL-BENZONITRILE

Cas:75344-77-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-bromo-3,5-dimethylbenzonitrile

Cas:75344-77-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

4-BROMO-3,5-DIMETHYL-BENZONITRILE

Cas:75344-77-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Changzhou Anchor Biological Technology Co., Ltd.

Our company is engaged in customizing the benzene ring and pyridine derivative organic intermediates, and the quantity is flexible according to customer's needs. It mainly provides high-quality intermediates for domestic and foreign pharmaceutical an

4-Bromo-3,5-dimethylbenzonitrile Manufacturer/High quality/Best price/In stock CAS NO.75344-77-3

Cas:75344-77-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Bromo-3,5-dimethylbenzonitrile cas no. 75344-77-3 98%

Cas:75344-77-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

4-Bromo-3,5-dimethyl-benzonitrile

Cas:75344-77-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-BROMO-3,5-DIMETHYL-BENZONITRILE

Cas:75344-77-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

4-BroMo-3,5-diMethylbenzonitrile

Cas:75344-77-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

4-Bromo-3,5-Dimethylbenzonitrile

Cas:75344-77-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

4-Bromo-3,5-dimethyl benzonitrile

Cas:75344-77-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Grams, Kilograms Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

4-BROMO-3,5-DIMETHYL-BENZONITRILE

Cas:75344-77-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

4-Bromo-3,5-dimethyl benzonitrile

Cas:75344-77-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-bromo-3,5-dimethylbenzaldehyde oxime
400822-49-3

4-bromo-3,5-dimethylbenzaldehyde oxime

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

Conditions
ConditionsYield
With carbon disulfide; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In toluene at 20℃; for 20h;75%
2-bromo-5-(bromomethyl)-1,3-dimethylbenzene
35510-00-0

2-bromo-5-(bromomethyl)-1,3-dimethylbenzene

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

Conditions
ConditionsYield
With ammonium hydroxide; iodine In acetonitrile at 60℃; for 4h; Solvent; Temperature; Inert atmosphere;73.5%
4-bromo-3,5-dimethylbenzaldehyde
400822-47-1

4-bromo-3,5-dimethylbenzaldehyde

A

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

B

4-bromo-3,5-dimethylbenzaldehyde oxime
400822-49-3

4-bromo-3,5-dimethylbenzaldehyde oxime

Conditions
ConditionsYield
With pyridine; hydroxylamine hydrochloride In toluene for 2h; Heating;A 39%
B 56%
4-bromo-3,5-dimethylbenzamide
864825-81-0

4-bromo-3,5-dimethylbenzamide

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

Conditions
ConditionsYield
With phosphorus pentachloride
1,4-dibromo-2,6-dimethylbenzene
100189-84-2

1,4-dibromo-2,6-dimethylbenzene

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: nBuLi / diethyl ether; hexane / 0.75 h / -78 °C
1.2: 79 percent / diethyl ether; hexane / -78 - 20 °C
2.1: 39 percent / hydroxylamine hydrochloride; pyridine / toluene / 2 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: nBuLi / diethyl ether; hexane / 0.75 h / -78 °C
1.2: 79 percent / diethyl ether; hexane / -78 - 20 °C
2.1: 56 percent / hydroxylamine hydrochloride; pyridine / toluene / 2 h / Heating
3.1: 75 percent / CS2; aq. NaOH; (nBu)4NHSO4 / toluene / 20 h / 20 °C
View Scheme
4-bromo-3,5-dimethylbenzaldehyde
400822-47-1

4-bromo-3,5-dimethylbenzaldehyde

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 56 percent / hydroxylamine hydrochloride; pyridine / toluene / 2 h / Heating
2: 75 percent / CS2; aq. NaOH; (nBu)4NHSO4 / toluene / 20 h / 20 °C
View Scheme
4-bromo-3,5-dimethylbenzoic acid
7697-32-7

4-bromo-3,5-dimethylbenzoic acid

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / Behandeln des erhaltenen Saeurechlorids mit wss. Ammoniak
2: phosphorus (V)-chloride
View Scheme
zinc(II) cyanide
557-21-1

zinc(II) cyanide

4-bromo-3,5-dimethylphenyl trifluoromethanesulfonate
864825-79-6

4-bromo-3,5-dimethylphenyl trifluoromethanesulfonate

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

Conditions
ConditionsYield
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl acetamide; acetonitrile at 50 - 88℃;
2,4,6-trimethylphenyl bromide
576-83-0

2,4,6-trimethylphenyl bromide

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-Bromosuccinimide; dibenzoyl peroxide / 1,2-dichloro-ethane / 2 h / 85 °C
2: ammonium hydroxide; iodine / acetonitrile / 4 h / 60 °C / Inert atmosphere
View Scheme
zinc(II) cyanide
557-21-1

zinc(II) cyanide

2-Bromo-m-xylene
576-22-7

2-Bromo-m-xylene

A

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

B

3-bromo-2,4-dimethylbenzonitrile

3-bromo-2,4-dimethylbenzonitrile

Conditions
ConditionsYield
With 3-(trifluoromethyl)quinoline; palladium diacetate; silver fluoride; N-acetylglycine at 80℃; for 18h; Overall yield = 65 %;
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

4-bromo-3,5-dimethylbenzoic acid
7697-32-7

4-bromo-3,5-dimethylbenzoic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol for 22h; Reflux;98%
With water; sodium hydroxide In ethanol at 120℃; for 12h; Sealed tube;
With water; sodium hydroxide at 95℃; for 17h;
isopropylboronic acid
80041-89-0

isopropylboronic acid

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

4-isopropyl-3,5-dimethylbenzonitrile

4-isopropyl-3,5-dimethylbenzonitrile

Conditions
ConditionsYield
With potassium phosphate monohydrate; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; C20H34O3P2 In toluene at 100℃; Suzuki-Miyaura Coupling; Inert atmosphere;96%
2-(3,4,5-trifluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
827614-70-0

2-(3,4,5-trifluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

3',4',5'-trifluoro-2,6-dimethyl-[1,1'-biphenyl]-4-carbonitrile

3',4',5'-trifluoro-2,6-dimethyl-[1,1'-biphenyl]-4-carbonitrile

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene at 85℃; Inert atmosphere;89.2%
mesitylboronic acid
5980-97-2

mesitylboronic acid

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

3,5-dimethyl-4-(2,4',6'-trimethylphenyl)-benzonitrile
76410-97-4

3,5-dimethyl-4-(2,4',6'-trimethylphenyl)-benzonitrile

Conditions
ConditionsYield
With BI-DIME; palladium diacetate; sodium t-butanolate In toluene at 110℃; for 12h; Suzuki-Miyaura Coupling; Inert atmosphere;88%
potassium tert-butyl N-[(difluoroboranyl)methyl]carbamate

potassium tert-butyl N-[(difluoroboranyl)methyl]carbamate

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

(4-cyano-2,6-dimethylbenzyl)carbamic acid tert-butyl ester
1618647-92-9

(4-cyano-2,6-dimethylbenzyl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); caesium carbonate In 1,4-dioxane; water at 110℃; for 16h; Inert atmosphere;86%
4-(diphenylamino)phenylboronic pinacol ester
267221-88-5

4-(diphenylamino)phenylboronic pinacol ester

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

C27H22N2

C27H22N2

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene at 85℃; for 24h; Inert atmosphere;84%
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

9-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-9H-3,9'-dicarbazole

9-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-9H-3,9'-dicarbazole

C39H27N3

C39H27N3

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene at 85℃; for 24h; Inert atmosphere;79%
9-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-9H-carbazole
785051-54-9

9-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-9H-carbazole

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

C27H20N2

C27H20N2

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene at 85℃; for 18h; Inert atmosphere;78.1%
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

Conditions
ConditionsYield
Stage #1: 4-bromo-3,5-dimethyl benzonitrile With n-butyllithium In tetrahydrofuran; hexane at -100℃; for 1.41667h;
Stage #2: With Trimethyl borate In tetrahydrofuran; hexane at -100 - 20℃;
77%
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -100 °C / Inert atmosphere
1.2: 12 h / -100 - 23 °C / Inert atmosphere
2.1: hydrogenchloride / water; tetrahydrofuran; hexane / 1 h / 23 °C / pH 2 / Inert atmosphere
View Scheme
10-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-10H-phenoxazine

10-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-10H-phenoxazine

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

C27H20N2O

C27H20N2O

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene at 85℃; for 24h; Inert atmosphere;77%
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

ethyl (S)-3-((tert-butoxycarbonyl)amino)-3-(2-fluoro-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate

ethyl (S)-3-((tert-butoxycarbonyl)amino)-3-(2-fluoro-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate

ethyl (S)-3-((tert-butoxycarbonyl)amino)-3-(4'-cyano-4-fluoro-2',5,6'-trimethyl-[1,1'-biphenyl]-3-yl)propanoate

ethyl (S)-3-((tert-butoxycarbonyl)amino)-3-(4'-cyano-4-fluoro-2',5,6'-trimethyl-[1,1'-biphenyl]-3-yl)propanoate

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 110℃; for 2h; Inert atmosphere;70%
10-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-10H-phenoxazine

10-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-10H-phenoxazine

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

C27H20N2O

C27H20N2O

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene at 85℃; for 24h; Inert atmosphere;69%
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

3,5-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile

3,5-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In N,N-dimethyl-formamide at 100℃; Inert atmosphere;65%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In N,N-dimethyl-formamide at 100℃; Inert atmosphere;65%
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In dimethyl sulfoxide at 90 - 100℃; for 24h; Inert atmosphere;57%
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In dimethyl sulfoxide at 90 - 100℃; for 24h; Inert atmosphere;57%
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester
93267-04-0

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester

methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyano-2,6-dimethylphenyl)propanoate
1227311-10-5

methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyano-2,6-dimethylphenyl)propanoate

Conditions
ConditionsYield
Stage #1: N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester With iodine; zinc In N,N-dimethyl-formamide at 20℃; for 0.666667h; Inert atmosphere;
Stage #2: 4-bromo-3,5-dimethyl benzonitrile With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0) In N,N-dimethyl-formamide at 50℃; Temperature;
50%
Stage #1: N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester With iodine; zinc In N,N-dimethyl acetamide at 21 - 29℃; Inert atmosphere;
Stage #2: 4-bromo-3,5-dimethyl benzonitrile; tris-(dibenzylideneacetone)dipalladium(0); tris-(o-tolyl)phosphine In N,N-dimethyl acetamide at 35 - 70℃; Product distribution / selectivity; Inert atmosphere;
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

3,5-dimethyl-4-formylbenzonitrile
157870-16-1

3,5-dimethyl-4-formylbenzonitrile

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane for 1h; Cooling with ether-dry ice;47%
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With oxygen; triethylamine; sodium iodide In acetonitrile at 32℃; for 24h; Schlenk technique; UV-irradiation;42%
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrene
349666-24-6

1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrene

3,5-dimethyl-4-(pyren-1-yl)benzonitrile

3,5-dimethyl-4-(pyren-1-yl)benzonitrile

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In toluene for 20h; Suzuki cross-coupling; Heating;28%
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

4-bromo-3,5-bis(bromomethyl)benzonitrile

4-bromo-3,5-bis(bromomethyl)benzonitrile

Conditions
ConditionsYield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane at 20℃; for 24h; Inert atmosphere; Schlenk technique; Glovebox;25%
5-(tributylstannyl)-[1,2,4]triazolo[1,5-a]pyridine
1332076-55-7

5-(tributylstannyl)-[1,2,4]triazolo[1,5-a]pyridine

4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

3,5-dimethyl-4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile

3,5-dimethyl-4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile

Conditions
ConditionsYield
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 120℃; for 0.333333h; Stille Cross-Coupling (Migita-Kosugi-Stille Coupling); Inert atmosphere; Sealed tube; Microwave irradiation;20%
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

4-bromo-N-hydroxy-3,5-dimethyl-benzamidine
1458656-36-4

4-bromo-N-hydroxy-3,5-dimethyl-benzamidine

Conditions
ConditionsYield
With hydroxylamine hydrochloride; triethylamine In ethanol for 4h; Reflux;
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

3-(4-bromo-3,5-dimethyl-phenyl)-5-methyl-[1,2,4]oxadiazole
1458656-37-5

3-(4-bromo-3,5-dimethyl-phenyl)-5-methyl-[1,2,4]oxadiazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydroxylamine hydrochloride; triethylamine / ethanol / 4 h / Reflux
2: 2,4,6-trimethyl-pyridine / 4 h / 20 - 120 °C
View Scheme
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

3-(4-bromo-3,5-dimethyl-phenyl)-5-(2-hydroxy-prop-2-yl)-[1,2,4]oxadiazole
1458656-41-1

3-(4-bromo-3,5-dimethyl-phenyl)-5-(2-hydroxy-prop-2-yl)-[1,2,4]oxadiazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydroxylamine hydrochloride; triethylamine / ethanol / 4 h / Reflux
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C
2.2: 20 - 110 °C
View Scheme

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