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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3,5-Dimethyl-4-hydroxybenzonitrile Manufacturer/High quality/Best price/In stock

Cas:4198-90-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Hydroxy-3,5-dimethylbenzonitrile

Cas:4198-90-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

4198-90-7 3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 4198-90-7 with competitive price

Cas:4198-90-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

4-hydroxy-3,5-dimethyl-benzenecarbonitrile 4198-90-7

Cas:4198-90-7

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3,5-Dimethyl-4-hydroxybenzonitrile 4198-90-7

Cas:4198-90-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

3,5-Dimethyl-4-hydroxybenzonitrile 99%

Cas:4198-90-7

Min.Order:1 Kilogram

FOB Price: $76.0 / 85.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

4-hydroxy-3,5-dimethyl-benzenecarbonitrile CAS:4198-90-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in hig

4-hydroxy-3,5-dimethyl-benzenecarbonitrile CAS:4198-90-7

Cas:4198-90-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

3,5-Dimethyl-4-hydroxybenzonitrile/ LIDE PHARMA- Factory supply / Best price

Cas:4198-90-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:4198-90-7

Cas:4198-90-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

4-hydroxy-3,5-dimethyl-benzenecarbonitrile

Cas:4198-90-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-Hydroxy-3,5-dimethylbenzonitrile

Cas:4198-90-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 3,5-Dimethyl-4-Hydroxybenzonitrile CAS No.: 4198-90-7 Molecule Formula:C9H9NO Molecule Weight:147.17 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Lower Price 3,5-Dimethyl-4-Hydroxybenzonitrile on stock

Cas:4198-90-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

4-hydroxy-3,5-dimethyl-benzenecarbonitrile Chemical Properties Melting point 123-127 °C Boiling point 267.28°C (rough estimate) density 1.1135 (rough estimate) refractive index 1.5290 (estimate) storage temp. Refrigerator

4-Hydroxy-3,5-dimethylbenzonitrile

Cas:4198-90-7

Min.Order:1 Gram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2,6-dimethyl-4-cyanophenol

Cas:4198-90-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Product Name: 3,5-Dimethyl-4-hydroxybenzonitrile Synonyms: 3,5-DIMETHYL-4-HYDROXYBENZONITRILE;4-HYDROXY-3,5-DIMETHYLBENZONITRILE;4-CYANO-2,6-DIMETHYL…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton

3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:0

Negotiable

Type:Other

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:White to beige crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Intermediate in the preparation o

3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

4-hydroxy-3,5-dimethylbenzonitrile

Cas:4198-90-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratoryAppearance:Yellow to brown solid Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Hydroxy-3,5-Dimethylbenzonitrile cas no. 4198-90-7 98%

Cas:4198-90-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air

3,5-Dimethyl-4-hydroxybenzonitrile

Cas:4198-90-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

4-Hydroxy-3,5-dimethylbenzonitrile

Cas:4198-90-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3,5-dimethyl-4-methoxybenzonitrile
152775-45-6

3,5-dimethyl-4-methoxybenzonitrile

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With boron trichloride; tetra-(n-butyl)ammonium iodide In n-heptane; dichloromethane at -78 - 0℃; for 2h; Inert atmosphere;83%
4-bromo-2,6-dimethyl-phenol
2374-05-2

4-bromo-2,6-dimethyl-phenol

malononitrile
109-77-3

malononitrile

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); sodium t-butanolate In 1-methyl-pyrrolidin-2-one at 130℃; for 24h;72%
2,6-dimethyl-4-chlorophenol
1123-63-3

2,6-dimethyl-4-chlorophenol

potassium ferrocyanide

potassium ferrocyanide

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; C21H34NPSi; sodium carbonate In N,N-dimethyl acetamide at 140℃; for 16h; Inert atmosphere;61%
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With oxygen; triethylamine; sodium iodide In acetonitrile at 32℃; for 24h; Schlenk technique; UV-irradiation;42%
4-amino-3,5-dimethylbenzonitrile
74896-24-5

4-amino-3,5-dimethylbenzonitrile

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
Stage #1: 4-amino-3,5-dimethylbenzonitrile With sulfuric acid In water at 5℃;
Stage #2: With water; sodium nitrite at 80℃; for 1.5h; Cooling;
28%
4-acetoxy-3,5-dimethyl-benzonitrile

4-acetoxy-3,5-dimethyl-benzonitrile

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With methanol; potassium carbonate
4-hydroxy-3,5-dimethyl-benzimidic acid ethyl ester

4-hydroxy-3,5-dimethyl-benzimidic acid ethyl ester

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With sodium hydroxide
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

2,6-dimethyl-1,4-benzoquinone
527-61-7

2,6-dimethyl-1,4-benzoquinone

A

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

B

4-hydroxy-2,6-dimethylbenzonitrile
58537-99-8

4-hydroxy-2,6-dimethylbenzonitrile

Conditions
ConditionsYield
With potassium cyanide; samarium diiodide; 18-crown-6 ether 1.) CH2Cl2, room t., 20 min, 2.) THF, MeOH, -78 deg C; Yield given. Multistep reaction. Yields of byproduct given;
4-bromo-2,6-dimethyl-phenol
2374-05-2

4-bromo-2,6-dimethyl-phenol

copper(I) cyanide
544-92-3

copper(I) cyanide

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide
5-bromo-2-methoxy-1,3-dimethylbenzene
14804-38-7

5-bromo-2-methoxy-1,3-dimethylbenzene

CuCN

CuCN

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With pyridine; copper(II) sulfate
2-methoxy-1,3-dimethylbenzene
1004-66-6

2-methoxy-1,3-dimethylbenzene

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: PBr3
2: CuSO4+5H2O; pyridine
View Scheme
Multi-step reaction with 2 steps
1.1: oxygen; N-iodo-succinimide; ytterbium(III) triflate / acetonitrile / 0.5 h / 150 °C
1.2: 60 h / 150 °C
2.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane; n-heptane / 2 h / -78 - 0 °C / Inert atmosphere
View Scheme
4-bromo-2,6-dimethyl-phenol
2374-05-2

4-bromo-2,6-dimethyl-phenol

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide
4-bromo-2,6-dichloro-phenol
3217-15-0

4-bromo-2,6-dichloro-phenol

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
CuCN In hexane; dichloromethane; N,N-dimethyl-formamide210 mg (28%)
zinc(II) cyanide
557-21-1

zinc(II) cyanide

C16H25BO4

C16H25BO4

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With copper(II) nitrate trihydrate; cesium fluoride In methanol; water at 100℃; for 4h;42.7 mg
4-((4,4-dimethyl-1-phenylpent-2-en-1-yl)oxy)-3,5-dimethylbenzonitrile
1414864-89-3

4-((4,4-dimethyl-1-phenylpent-2-en-1-yl)oxy)-3,5-dimethylbenzonitrile

A

4-((4,4-dimethyl-1-phenylpent-1-en-3-yl)oxy)-3,5-dimethylbenzonitrile

4-((4,4-dimethyl-1-phenylpent-1-en-3-yl)oxy)-3,5-dimethylbenzonitrile

B

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
In 1,2-dichloro-benzene for 2h; Reflux;A 75 %Spectr.
B 9 %Spectr.
4-bromo-2,6-dimethylphenylamine
24596-19-8

4-bromo-2,6-dimethylphenylamine

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere
2.1: sulfuric acid / water / 5 °C
2.2: 1.5 h / 80 °C / Cooling
View Scheme
2,6-dimethylaniline
87-62-7

2,6-dimethylaniline

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid; boric acid; dihydrogen peroxide; potassium bromide / water / 3 h / 20 °C
2.1: copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere
3.1: sulfuric acid / water / 5 °C
3.2: 1.5 h / 80 °C / Cooling
View Scheme
2.6-dimethylphenol
576-26-1

2.6-dimethylphenol

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-Bromosuccinimide
2: N,N-dimethyl-formamide
View Scheme
4-bromo-2,6-dimethyl-phenol
2374-05-2

4-bromo-2,6-dimethyl-phenol

copper(l) cyanide

copper(l) cyanide

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide
3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

allyl bromide
106-95-6

allyl bromide

4-(allyloxy)-3,5-dimethylbenzonitrile
100191-87-5

4-(allyloxy)-3,5-dimethylbenzonitrile

Conditions
ConditionsYield
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 0.333333h;
Stage #2: allyl bromide With sodium hydride In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
100%
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: allyl bromide In N,N-dimethyl-formamide at 20℃; for 5h;
98%
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h;
Stage #2: allyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 5h;
98%
3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

4-(aminomethyl)-2,6-dimethylphenol hydrochloride
937-36-0

4-(aminomethyl)-2,6-dimethylphenol hydrochloride

Conditions
ConditionsYield
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With borane-THF In tetrahydrofuran for 16h; Heating / reflux;
Stage #2: With hydrogenchloride In tetrahydrofuran; water for 0.5h; Heating / reflux;
100%
3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

benzyl bromide
100-39-0

benzyl bromide

4-(benzyloxy)-3,5-dimethylbenzonitrile
924300-31-2

4-(benzyloxy)-3,5-dimethylbenzonitrile

Conditions
ConditionsYield
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 24h; Product distribution / selectivity;
100%
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h;
Stage #2: benzyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 24h;
100%
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: benzyl bromide at 20℃; for 24h;
100%
N,N-phenylbistrifluoromethane-sulfonimide
37595-74-7

N,N-phenylbistrifluoromethane-sulfonimide

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

4-cyano-2,6-dimethylphenyl trifluoromethanesulfonate
955929-58-5

4-cyano-2,6-dimethylphenyl trifluoromethanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;100%
With triethylamine In DCM at 20℃;100%
With triethylamine In dichloromethane at 20℃;100%
3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

(Z)-N',4-dihydroxy-3,5-dimethylbenzimidamide

(Z)-N',4-dihydroxy-3,5-dimethylbenzimidamide

Conditions
ConditionsYield
With hydroxylamine In ethanol; water at 90℃; for 16h;100%
silicon dioxide hydrate
23382-09-4

silicon dioxide hydrate

1-chloro-4-pentyne
14267-92-6

1-chloro-4-pentyne

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

3-(3-methylisoxazol-5-yl)propyl chloride
130800-76-9

3-(3-methylisoxazol-5-yl)propyl chloride

3,5-dimethyl-4-(pent-4-yn-1-yloxy)benzonitrile
134472-29-0

3,5-dimethyl-4-(pent-4-yn-1-yloxy)benzonitrile

Conditions
ConditionsYield
In ethyl acetate99.4%
In ethyl acetate99.4%
3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

methyl 2-(4-cyano-2,6-dimethylphenoxy)acetate
1479630-16-4

methyl 2-(4-cyano-2,6-dimethylphenoxy)acetate

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 80℃; for 2h;99%
3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

5,7-dichloropyrazolo[1,5-a]pyrimidine
57489-77-7

5,7-dichloropyrazolo[1,5-a]pyrimidine

C15H11ClN4O
1564252-97-6

C15H11ClN4O

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;98.1%
3-chloro-2-methylpropan-2-ol
558-42-9

3-chloro-2-methylpropan-2-ol

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

4-(2-hydroxy-2-methylpropoxy)-3,5-dimethyl benzonitrile
924300-38-9

4-(2-hydroxy-2-methylpropoxy)-3,5-dimethyl benzonitrile

Conditions
ConditionsYield
With potassium carbonate In ethanol; water for 24h; Heating / reflux;97%
With potassium carbonate In ethanol; water for 24h; Heating / reflux;97%
With potassium carbonate In ethanol; water at 20℃; for 24h; Reflux;97%
With potassium carbonate In ethanol; water for 24h; Reflux;97%
With potassium carbonate In ethanol; water for 24h; Heating / reflux;97%
2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine
5466-43-3

2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

4-((2-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

4-((2-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;97%
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: 2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine In N,N-dimethyl-formamide for 2h;
93.1%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;
3,5-dimethyl-4-methoxybenzonitrile
152775-45-6

3,5-dimethyl-4-methoxybenzonitrile

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With boron trichloride; tetra-(n-butyl)ammonium iodide In n-heptane; dichloromethane at -78 - 0℃; for 2h; Inert atmosphere;83%
4-bromo-2,6-dimethyl-phenol
2374-05-2

4-bromo-2,6-dimethyl-phenol

malononitrile
109-77-3

malononitrile

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); sodium t-butanolate In 1-methyl-pyrrolidin-2-one at 130℃; for 24h;72%
2,6-dimethyl-4-chlorophenol
1123-63-3

2,6-dimethyl-4-chlorophenol

potassium ferrocyanide

potassium ferrocyanide

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; C21H34NPSi; sodium carbonate In N,N-dimethyl acetamide at 140℃; for 16h; Inert atmosphere;61%
4-bromo-3,5-dimethyl benzonitrile
75344-77-3

4-bromo-3,5-dimethyl benzonitrile

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With oxygen; triethylamine; sodium iodide In acetonitrile at 32℃; for 24h; Schlenk technique; UV-irradiation;42%
4-amino-3,5-dimethylbenzonitrile
74896-24-5

4-amino-3,5-dimethylbenzonitrile

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
Stage #1: 4-amino-3,5-dimethylbenzonitrile With sulfuric acid In water at 5℃;
Stage #2: With water; sodium nitrite at 80℃; for 1.5h; Cooling;
28%
4-acetoxy-3,5-dimethyl-benzonitrile

4-acetoxy-3,5-dimethyl-benzonitrile

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With methanol; potassium carbonate
4-hydroxy-3,5-dimethyl-benzimidic acid ethyl ester

4-hydroxy-3,5-dimethyl-benzimidic acid ethyl ester

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With sodium hydroxide
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

2,6-dimethyl-1,4-benzoquinone
527-61-7

2,6-dimethyl-1,4-benzoquinone

A

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

B

4-hydroxy-2,6-dimethylbenzonitrile
58537-99-8

4-hydroxy-2,6-dimethylbenzonitrile

Conditions
ConditionsYield
With potassium cyanide; samarium diiodide; 18-crown-6 ether 1.) CH2Cl2, room t., 20 min, 2.) THF, MeOH, -78 deg C; Yield given. Multistep reaction. Yields of byproduct given;
4-bromo-2,6-dimethyl-phenol
2374-05-2

4-bromo-2,6-dimethyl-phenol

copper(I) cyanide
544-92-3

copper(I) cyanide

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide
5-bromo-2-methoxy-1,3-dimethylbenzene
14804-38-7

5-bromo-2-methoxy-1,3-dimethylbenzene

CuCN

CuCN

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With pyridine; copper(II) sulfate
2-methoxy-1,3-dimethylbenzene
1004-66-6

2-methoxy-1,3-dimethylbenzene

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: PBr3
2: CuSO4+5H2O; pyridine
View Scheme
Multi-step reaction with 2 steps
1.1: oxygen; N-iodo-succinimide; ytterbium(III) triflate / acetonitrile / 0.5 h / 150 °C
1.2: 60 h / 150 °C
2.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane; n-heptane / 2 h / -78 - 0 °C / Inert atmosphere
View Scheme
4-bromo-2,6-dimethyl-phenol
2374-05-2

4-bromo-2,6-dimethyl-phenol

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide
4-bromo-2,6-dichloro-phenol
3217-15-0

4-bromo-2,6-dichloro-phenol

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
CuCN In hexane; dichloromethane; N,N-dimethyl-formamide210 mg (28%)
zinc(II) cyanide
557-21-1

zinc(II) cyanide

C16H25BO4

C16H25BO4

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
With copper(II) nitrate trihydrate; cesium fluoride In methanol; water at 100℃; for 4h;42.7 mg
4-((4,4-dimethyl-1-phenylpent-2-en-1-yl)oxy)-3,5-dimethylbenzonitrile
1414864-89-3

4-((4,4-dimethyl-1-phenylpent-2-en-1-yl)oxy)-3,5-dimethylbenzonitrile

A

4-((4,4-dimethyl-1-phenylpent-1-en-3-yl)oxy)-3,5-dimethylbenzonitrile

4-((4,4-dimethyl-1-phenylpent-1-en-3-yl)oxy)-3,5-dimethylbenzonitrile

B

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
In 1,2-dichloro-benzene for 2h; Reflux;A 75 %Spectr.
B 9 %Spectr.
4-bromo-2,6-dimethylphenylamine
24596-19-8

4-bromo-2,6-dimethylphenylamine

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere
2.1: sulfuric acid / water / 5 °C
2.2: 1.5 h / 80 °C / Cooling
View Scheme
2,6-dimethylaniline
87-62-7

2,6-dimethylaniline

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid; boric acid; dihydrogen peroxide; potassium bromide / water / 3 h / 20 °C
2.1: copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere
3.1: sulfuric acid / water / 5 °C
3.2: 1.5 h / 80 °C / Cooling
View Scheme
2.6-dimethylphenol
576-26-1

2.6-dimethylphenol

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-Bromosuccinimide
2: N,N-dimethyl-formamide
View Scheme
4-bromo-2,6-dimethyl-phenol
2374-05-2

4-bromo-2,6-dimethyl-phenol

copper(l) cyanide

copper(l) cyanide

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide
3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

allyl bromide
106-95-6

allyl bromide

4-(allyloxy)-3,5-dimethylbenzonitrile
100191-87-5

4-(allyloxy)-3,5-dimethylbenzonitrile

Conditions
ConditionsYield
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 0.333333h;
Stage #2: allyl bromide With sodium hydride In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
100%
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: allyl bromide In N,N-dimethyl-formamide at 20℃; for 5h;
98%
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h;
Stage #2: allyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 5h;
98%
3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

4-(aminomethyl)-2,6-dimethylphenol hydrochloride
937-36-0

4-(aminomethyl)-2,6-dimethylphenol hydrochloride

Conditions
ConditionsYield
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With borane-THF In tetrahydrofuran for 16h; Heating / reflux;
Stage #2: With hydrogenchloride In tetrahydrofuran; water for 0.5h; Heating / reflux;
100%
3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

benzyl bromide
100-39-0

benzyl bromide

4-(benzyloxy)-3,5-dimethylbenzonitrile
924300-31-2

4-(benzyloxy)-3,5-dimethylbenzonitrile

Conditions
ConditionsYield
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 24h; Product distribution / selectivity;
100%
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h;
Stage #2: benzyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 24h;
100%
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: benzyl bromide at 20℃; for 24h;
100%
N,N-phenylbistrifluoromethane-sulfonimide
37595-74-7

N,N-phenylbistrifluoromethane-sulfonimide

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

4-cyano-2,6-dimethylphenyl trifluoromethanesulfonate
955929-58-5

4-cyano-2,6-dimethylphenyl trifluoromethanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;100%
With triethylamine In DCM at 20℃;100%
With triethylamine In dichloromethane at 20℃;100%
3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

(Z)-N',4-dihydroxy-3,5-dimethylbenzimidamide

(Z)-N',4-dihydroxy-3,5-dimethylbenzimidamide

Conditions
ConditionsYield
With hydroxylamine In ethanol; water at 90℃; for 16h;100%
silicon dioxide hydrate
23382-09-4

silicon dioxide hydrate

1-chloro-4-pentyne
14267-92-6

1-chloro-4-pentyne

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

3-(3-methylisoxazol-5-yl)propyl chloride
130800-76-9

3-(3-methylisoxazol-5-yl)propyl chloride

3,5-dimethyl-4-(pent-4-yn-1-yloxy)benzonitrile
134472-29-0

3,5-dimethyl-4-(pent-4-yn-1-yloxy)benzonitrile

Conditions
ConditionsYield
In ethyl acetate99.4%
In ethyl acetate99.4%
3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

methyl 2-(4-cyano-2,6-dimethylphenoxy)acetate
1479630-16-4

methyl 2-(4-cyano-2,6-dimethylphenoxy)acetate

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 80℃; for 2h;99%
3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

5,7-dichloropyrazolo[1,5-a]pyrimidine
57489-77-7

5,7-dichloropyrazolo[1,5-a]pyrimidine

C15H11ClN4O
1564252-97-6

C15H11ClN4O

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;98.1%
3-chloro-2-methylpropan-2-ol
558-42-9

3-chloro-2-methylpropan-2-ol

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

4-(2-hydroxy-2-methylpropoxy)-3,5-dimethyl benzonitrile
924300-38-9

4-(2-hydroxy-2-methylpropoxy)-3,5-dimethyl benzonitrile

Conditions
ConditionsYield
With potassium carbonate In ethanol; water for 24h; Heating / reflux;97%
With potassium carbonate In ethanol; water for 24h; Heating / reflux;97%
With potassium carbonate In ethanol; water at 20℃; for 24h; Reflux;97%
With potassium carbonate In ethanol; water for 24h; Reflux;97%
With potassium carbonate In ethanol; water for 24h; Heating / reflux;97%
2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine
5466-43-3

2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

4-((2-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

4-((2-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;97%
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: 2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine In N,N-dimethyl-formamide for 2h;
93.1%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

4-((2-chloropyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile
1033954-42-5

4-((2-chloropyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

Conditions
ConditionsYield
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: 2,6-Dichloropyrimidine In N,N-dimethyl-formamide at 20℃; for 5h;
96%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 5h;90%
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 2,6-Dichloropyrimidine In tetrahydrofuran at 20℃; for 6h;
88.8%
2,4-dichloro-furo[3,2-d]pyrimidine
956034-07-4

2,4-dichloro-furo[3,2-d]pyrimidine

3,5-dimethyl-4-hydroxybenzonitrile
4198-90-7

3,5-dimethyl-4-hydroxybenzonitrile

4-( (2-chlorofuro[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

4-( (2-chlorofuro[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

Conditions
ConditionsYield
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: 2,4-dichloro-furo[3,2-d]pyrimidine at 20℃; for 2h;
96%
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: 2,4-dichloro-furo[3,2-d]pyrimidine In N,N-dimethyl-formamide for 2h;
86.7%

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