Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:4198-90-7
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Cas:4198-90-7
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Cas:4198-90-7
Min.Order:1 Kilogram
FOB Price: $5.0
Type:Manufacturers
inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Cas:4198-90-7
Min.Order:0
Negotiable
Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:4198-90-7
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:4198-90-7
Min.Order:1 Kilogram
FOB Price: $1000.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:4198-90-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:4198-90-7
Min.Order:1 Kilogram
FOB Price: $15.0 / 50.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:4198-90-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:4198-90-7
Min.Order:1 Kilogram
FOB Price: $76.0 / 85.0
Type:Trading Company
inquiry4-hydroxy-3,5-dimethyl-benzenecarbonitrile CAS:4198-90-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in hig
Cas:4198-90-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:4198-90-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:4198-90-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:4198-90-7
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryour strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery
Cas:4198-90-7
Min.Order:1 Gram
Negotiable
Type:Other
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:4198-90-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:4198-90-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryProduct name: 3,5-Dimethyl-4-Hydroxybenzonitrile CAS No.: 4198-90-7 Molecule Formula:C9H9NO Molecule Weight:147.17 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:4198-90-7
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry4-hydroxy-3,5-dimethyl-benzenecarbonitrile Chemical Properties Melting point 123-127 °C Boiling point 267.28°C (rough estimate) density 1.1135 (rough estimate) refractive index 1.5290 (estimate) storage temp. Refrigerator
Cas:4198-90-7
Min.Order:1 Gram
FOB Price: $65.0
Type:Lab/Research institutions
inquiryHANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
Product Name: 3,5-Dimethyl-4-hydroxybenzonitrile Synonyms: 3,5-DIMETHYL-4-HYDROXYBENZONITRILE;4-HYDROXY-3,5-DIMETHYLBENZONITRILE;4-CYANO-2,6-DIMETHYL…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton
High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
Cas:4198-90-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:White to beige crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Intermediate in the preparation o
Cas:4198-90-7
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryShanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service
Cas:4198-90-7
Min.Order:0
Negotiable
Type:Trading Company
inquiryStock products, own laboratoryAppearance:Yellow to brown solid Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:4198-90-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryR & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air
high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier
Cas:4198-90-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry3,5-dimethyl-4-methoxybenzonitrile
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With boron trichloride; tetra-(n-butyl)ammonium iodide In n-heptane; dichloromethane at -78 - 0℃; for 2h; Inert atmosphere; | 83% |
4-bromo-2,6-dimethyl-phenol
malononitrile
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); sodium t-butanolate In 1-methyl-pyrrolidin-2-one at 130℃; for 24h; | 72% |
Conditions | Yield |
---|---|
With palladium(II) trifluoroacetate; C21H34NPSi; sodium carbonate In N,N-dimethyl acetamide at 140℃; for 16h; Inert atmosphere; | 61% |
4-bromo-3,5-dimethyl benzonitrile
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With oxygen; triethylamine; sodium iodide In acetonitrile at 32℃; for 24h; Schlenk technique; UV-irradiation; | 42% |
4-amino-3,5-dimethylbenzonitrile
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
Stage #1: 4-amino-3,5-dimethylbenzonitrile With sulfuric acid In water at 5℃; Stage #2: With water; sodium nitrite at 80℃; for 1.5h; Cooling; | 28% |
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With methanol; potassium carbonate |
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With sodium hydroxide |
trimethylsilyl cyanide
2,6-dimethyl-1,4-benzoquinone
A
3,5-dimethyl-4-hydroxybenzonitrile
B
4-hydroxy-2,6-dimethylbenzonitrile
Conditions | Yield |
---|---|
With potassium cyanide; samarium diiodide; 18-crown-6 ether 1.) CH2Cl2, room t., 20 min, 2.) THF, MeOH, -78 deg C; Yield given. Multistep reaction. Yields of byproduct given; |
4-bromo-2,6-dimethyl-phenol
copper(I) cyanide
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide |
5-bromo-2-methoxy-1,3-dimethylbenzene
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With pyridine; copper(II) sulfate |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: PBr3 2: CuSO4+5H2O; pyridine View Scheme | |
Multi-step reaction with 2 steps 1.1: oxygen; N-iodo-succinimide; ytterbium(III) triflate / acetonitrile / 0.5 h / 150 °C 1.2: 60 h / 150 °C 2.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane; n-heptane / 2 h / -78 - 0 °C / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide |
Conditions | Yield |
---|---|
CuCN In hexane; dichloromethane; N,N-dimethyl-formamide | 210 mg (28%) |
Conditions | Yield |
---|---|
With copper(II) nitrate trihydrate; cesium fluoride In methanol; water at 100℃; for 4h; | 42.7 mg |
4-((4,4-dimethyl-1-phenylpent-2-en-1-yl)oxy)-3,5-dimethylbenzonitrile
B
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
In 1,2-dichloro-benzene for 2h; Reflux; | A 75 %Spectr. B 9 %Spectr. |
4-bromo-2,6-dimethylphenylamine
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere 2.1: sulfuric acid / water / 5 °C 2.2: 1.5 h / 80 °C / Cooling View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sulfuric acid; boric acid; dihydrogen peroxide; potassium bromide / water / 3 h / 20 °C 2.1: copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere 3.1: sulfuric acid / water / 5 °C 3.2: 1.5 h / 80 °C / Cooling View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-Bromosuccinimide 2: N,N-dimethyl-formamide View Scheme |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide |
3,5-dimethyl-4-hydroxybenzonitrile
allyl bromide
4-(allyloxy)-3,5-dimethylbenzonitrile
Conditions | Yield |
---|---|
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 0.333333h; Stage #2: allyl bromide With sodium hydride In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 100% |
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: allyl bromide In N,N-dimethyl-formamide at 20℃; for 5h; | 98% |
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Stage #2: allyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 5h; | 98% |
3,5-dimethyl-4-hydroxybenzonitrile
4-(aminomethyl)-2,6-dimethylphenol hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With borane-THF In tetrahydrofuran for 16h; Heating / reflux; Stage #2: With hydrogenchloride In tetrahydrofuran; water for 0.5h; Heating / reflux; | 100% |
3,5-dimethyl-4-hydroxybenzonitrile
benzyl bromide
4-(benzyloxy)-3,5-dimethylbenzonitrile
Conditions | Yield |
---|---|
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 24h; Product distribution / selectivity; | 100% |
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Stage #2: benzyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 24h; | 100% |
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: benzyl bromide at 20℃; for 24h; | 100% |
N,N-phenylbistrifluoromethane-sulfonimide
3,5-dimethyl-4-hydroxybenzonitrile
4-cyano-2,6-dimethylphenyl trifluoromethanesulfonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; | 100% |
With triethylamine In DCM at 20℃; | 100% |
With triethylamine In dichloromethane at 20℃; | 100% |
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With hydroxylamine In ethanol; water at 90℃; for 16h; | 100% |
silicon dioxide hydrate
1-chloro-4-pentyne
3,5-dimethyl-4-hydroxybenzonitrile
3-(3-methylisoxazol-5-yl)propyl chloride
3,5-dimethyl-4-(pent-4-yn-1-yloxy)benzonitrile
Conditions | Yield |
---|---|
In ethyl acetate | 99.4% |
In ethyl acetate | 99.4% |
3,5-dimethyl-4-hydroxybenzonitrile
bromoacetic acid methyl ester
methyl 2-(4-cyano-2,6-dimethylphenoxy)acetate
Conditions | Yield |
---|---|
With caesium carbonate In acetonitrile at 80℃; for 2h; | 99% |
3,5-dimethyl-4-hydroxybenzonitrile
5,7-dichloropyrazolo[1,5-a]pyrimidine
C15H11ClN4O
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; | 98.1% |
3-chloro-2-methylpropan-2-ol
3,5-dimethyl-4-hydroxybenzonitrile
4-(2-hydroxy-2-methylpropoxy)-3,5-dimethyl benzonitrile
Conditions | Yield |
---|---|
With potassium carbonate In ethanol; water for 24h; Heating / reflux; | 97% |
With potassium carbonate In ethanol; water for 24h; Heating / reflux; | 97% |
With potassium carbonate In ethanol; water at 20℃; for 24h; Reflux; | 97% |
With potassium carbonate In ethanol; water for 24h; Reflux; | 97% |
With potassium carbonate In ethanol; water for 24h; Heating / reflux; | 97% |
2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 97% |
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: 2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine In N,N-dimethyl-formamide for 2h; | 93.1% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; |
3,5-dimethyl-4-methoxybenzonitrile
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With boron trichloride; tetra-(n-butyl)ammonium iodide In n-heptane; dichloromethane at -78 - 0℃; for 2h; Inert atmosphere; | 83% |
4-bromo-2,6-dimethyl-phenol
malononitrile
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); sodium t-butanolate In 1-methyl-pyrrolidin-2-one at 130℃; for 24h; | 72% |
Conditions | Yield |
---|---|
With palladium(II) trifluoroacetate; C21H34NPSi; sodium carbonate In N,N-dimethyl acetamide at 140℃; for 16h; Inert atmosphere; | 61% |
4-bromo-3,5-dimethyl benzonitrile
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With oxygen; triethylamine; sodium iodide In acetonitrile at 32℃; for 24h; Schlenk technique; UV-irradiation; | 42% |
4-amino-3,5-dimethylbenzonitrile
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
Stage #1: 4-amino-3,5-dimethylbenzonitrile With sulfuric acid In water at 5℃; Stage #2: With water; sodium nitrite at 80℃; for 1.5h; Cooling; | 28% |
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With methanol; potassium carbonate |
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With sodium hydroxide |
trimethylsilyl cyanide
2,6-dimethyl-1,4-benzoquinone
A
3,5-dimethyl-4-hydroxybenzonitrile
B
4-hydroxy-2,6-dimethylbenzonitrile
Conditions | Yield |
---|---|
With potassium cyanide; samarium diiodide; 18-crown-6 ether 1.) CH2Cl2, room t., 20 min, 2.) THF, MeOH, -78 deg C; Yield given. Multistep reaction. Yields of byproduct given; |
4-bromo-2,6-dimethyl-phenol
copper(I) cyanide
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide |
5-bromo-2-methoxy-1,3-dimethylbenzene
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With pyridine; copper(II) sulfate |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: PBr3 2: CuSO4+5H2O; pyridine View Scheme | |
Multi-step reaction with 2 steps 1.1: oxygen; N-iodo-succinimide; ytterbium(III) triflate / acetonitrile / 0.5 h / 150 °C 1.2: 60 h / 150 °C 2.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane; n-heptane / 2 h / -78 - 0 °C / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide |
Conditions | Yield |
---|---|
CuCN In hexane; dichloromethane; N,N-dimethyl-formamide | 210 mg (28%) |
Conditions | Yield |
---|---|
With copper(II) nitrate trihydrate; cesium fluoride In methanol; water at 100℃; for 4h; | 42.7 mg |
4-((4,4-dimethyl-1-phenylpent-2-en-1-yl)oxy)-3,5-dimethylbenzonitrile
B
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
In 1,2-dichloro-benzene for 2h; Reflux; | A 75 %Spectr. B 9 %Spectr. |
4-bromo-2,6-dimethylphenylamine
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere 2.1: sulfuric acid / water / 5 °C 2.2: 1.5 h / 80 °C / Cooling View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sulfuric acid; boric acid; dihydrogen peroxide; potassium bromide / water / 3 h / 20 °C 2.1: copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere 3.1: sulfuric acid / water / 5 °C 3.2: 1.5 h / 80 °C / Cooling View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-Bromosuccinimide 2: N,N-dimethyl-formamide View Scheme |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide |
3,5-dimethyl-4-hydroxybenzonitrile
allyl bromide
4-(allyloxy)-3,5-dimethylbenzonitrile
Conditions | Yield |
---|---|
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 0.333333h; Stage #2: allyl bromide With sodium hydride In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 100% |
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: allyl bromide In N,N-dimethyl-formamide at 20℃; for 5h; | 98% |
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Stage #2: allyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 5h; | 98% |
3,5-dimethyl-4-hydroxybenzonitrile
4-(aminomethyl)-2,6-dimethylphenol hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With borane-THF In tetrahydrofuran for 16h; Heating / reflux; Stage #2: With hydrogenchloride In tetrahydrofuran; water for 0.5h; Heating / reflux; | 100% |
3,5-dimethyl-4-hydroxybenzonitrile
benzyl bromide
4-(benzyloxy)-3,5-dimethylbenzonitrile
Conditions | Yield |
---|---|
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 24h; Product distribution / selectivity; | 100% |
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Stage #2: benzyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 24h; | 100% |
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: benzyl bromide at 20℃; for 24h; | 100% |
N,N-phenylbistrifluoromethane-sulfonimide
3,5-dimethyl-4-hydroxybenzonitrile
4-cyano-2,6-dimethylphenyl trifluoromethanesulfonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; | 100% |
With triethylamine In DCM at 20℃; | 100% |
With triethylamine In dichloromethane at 20℃; | 100% |
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With hydroxylamine In ethanol; water at 90℃; for 16h; | 100% |
silicon dioxide hydrate
1-chloro-4-pentyne
3,5-dimethyl-4-hydroxybenzonitrile
3-(3-methylisoxazol-5-yl)propyl chloride
3,5-dimethyl-4-(pent-4-yn-1-yloxy)benzonitrile
Conditions | Yield |
---|---|
In ethyl acetate | 99.4% |
In ethyl acetate | 99.4% |
3,5-dimethyl-4-hydroxybenzonitrile
bromoacetic acid methyl ester
methyl 2-(4-cyano-2,6-dimethylphenoxy)acetate
Conditions | Yield |
---|---|
With caesium carbonate In acetonitrile at 80℃; for 2h; | 99% |
3,5-dimethyl-4-hydroxybenzonitrile
5,7-dichloropyrazolo[1,5-a]pyrimidine
C15H11ClN4O
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; | 98.1% |
3-chloro-2-methylpropan-2-ol
3,5-dimethyl-4-hydroxybenzonitrile
4-(2-hydroxy-2-methylpropoxy)-3,5-dimethyl benzonitrile
Conditions | Yield |
---|---|
With potassium carbonate In ethanol; water for 24h; Heating / reflux; | 97% |
With potassium carbonate In ethanol; water for 24h; Heating / reflux; | 97% |
With potassium carbonate In ethanol; water at 20℃; for 24h; Reflux; | 97% |
With potassium carbonate In ethanol; water for 24h; Reflux; | 97% |
With potassium carbonate In ethanol; water for 24h; Heating / reflux; | 97% |
2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 97% |
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: 2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine In N,N-dimethyl-formamide for 2h; | 93.1% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; |
2,6-Dichloropyrimidine
3,5-dimethyl-4-hydroxybenzonitrile
4-((2-chloropyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile
Conditions | Yield |
---|---|
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: 2,6-Dichloropyrimidine In N,N-dimethyl-formamide at 20℃; for 5h; | 96% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 5h; | 90% |
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2,6-Dichloropyrimidine In tetrahydrofuran at 20℃; for 6h; | 88.8% |
2,4-dichloro-furo[3,2-d]pyrimidine
3,5-dimethyl-4-hydroxybenzonitrile
Conditions | Yield |
---|---|
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: 2,4-dichloro-furo[3,2-d]pyrimidine at 20℃; for 2h; | 96% |
Stage #1: 3,5-dimethyl-4-hydroxybenzonitrile With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: 2,4-dichloro-furo[3,2-d]pyrimidine In N,N-dimethyl-formamide for 2h; | 86.7% |
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