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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid 754159-68-7

Cas:754159-68-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid

Cas:754159-68-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Lonwin Chemical Group Limited

3-[(1R)-3-[Bis(1-methylethyl)amino]-1-... CAS: 754159-68-7 Specificatio Welcome to contact us to get complete COA. Shanghai Lonwin Chem is a leading manufacturer and supplier of chemicals in China.We develop,produce and distribute high q

Factory supply 3-[(1R)-3-[Bis(1-methylethyl)amino]-1-...

Cas:754159-68-7

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-[(1R)-3-[BIS(1-METHYLETHYL)AMINO]-1-PHENYLPROPYL]-4-(PHENYLMETHOXY)BENZOIC ACID

Cas:754159-68-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid

Cas:754159-68-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Benzoicacid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-

Cas:754159-68-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(R)-4-Benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)benzoic acid

Cas:754159-68-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

Benzoicacid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-

Cas:754159-68-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

Benzoicacid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-

Cas:754159-68-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid

Cas:754159-68-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid cas 754159-68-7Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by

Taixing Hehao Chemical Materials Co.,Ltd

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid

Cas:754159-68-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

suzhou BetterBioChem Co., Ltd.

Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

3-[(1R)-3-[BIS(1-METHYLETHYL)AMINO]-1-PHENYLPROPYL]-4-(PHENYLMETHOXY)BENZOIC ACID

Cas:754159-68-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen BaiFuchem Co.,Ltd

BaiFuChem is a Professional chemical raw material supplier in China, our main products include Biochemical , Pharma Intermediate and Organic chemical etc. BaiFuChem have wealth of products,experience , expertise and state-of-the-art

Reliable Pharmatech (Tianjin) Co., Ltd.

This product is manufactured in commercial scale, with Perfect quality and Competitive price Expert in pharmaceutical technology Professional service in technic, documentation, export, etc. Steady and continuous supply chain Reliable Pharma

(R)-(-)-4-Benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)-benzoicacid

Cas:754159-68-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

ORCHID CHEMICAL SUPPLIES LTD

3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-Benzoic acid or R)-4-benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)benzoic acid supplierAppearance:almost white powder Storage:Keep away of light,cool place Package:25kg/drum;200k

Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

Benzoicacid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-

Cas:754159-68-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan MoonZY Biological Technology Co.,Ltd

instock with good quality and wholesale price Storage:Keep in a cool & dry place Package:Packing material and QTY as your request Application:Pharma;Industry;other application Transportation:Express or as your request Port:Any port of China

3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid,754159-68-7

Cas:754159-68-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Ikg Chemical Co., Ltd.

IKGCHEM is a leading manufacturer and supplier of chemical in China.As a Professional chemical raw material supplier,our products are produced in accordance with ISO 9001:2015 Quality Management System and ISO14001:15602 Environmental Management Syst

Hangzhou Yierdechem Co. Ltd

With about ten years experiences in the field of pharmaceutical chemicals, Yierdechem has established solid business cooperation relationships with many large companys worldwide.As a leading supplier of API and pharmaceutical intermediates, holds its

(R)-4-Benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)benzoic acid

Cas:754159-68-7

Min.Order:0

Negotiable

Type:Other

inquiry

SHANGHAI ARCADIA BIOTECHNOLOGY LTD.

Appearance:Standard Storage:according to MSDS Package:As required Transportation:By sea Port:shanghai

3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid

Cas:754159-68-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Finetech Industry Limited

High Quality Best Price Storage:Store in dry, dark and ventilated place Application:Chemical Synthesis Intermediate

FT-0773503

Cas:754159-68-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(E)-3-phenylacrylic acid
140-10-3

(E)-3-phenylacrylic acid

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sulfuric acid / 120 - 125 °C
2.1: potassium carbonate; sodium iodide / acetone / Reflux
3.1: sodium tetrahydroborate / 1,2-dimethoxyethane / 0.17 h
3.2: 3 h / 10 °C
4.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C
5.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
6.1: isopropyl alcohol / 15 h / 25 - 86 °C
7.1: sodium hydroxide / water
8.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
8.2: 1 h / -65 - -60 °C
View Scheme
R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine
950773-38-3

R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine

carbon dioxide
124-38-9

carbon dioxide

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Stage #1: R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine With ethyl bromide; iodine; magnesium In tetrahydrofuran at 55℃; for 1h; Reflux;
Stage #2: carbon dioxide In tetrahydrofuran at -65 - -60℃; for 1h;
Stage #1: R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine With ethyl bromide; iodine; magnesium In tetrahydrofuran at 60 - 65℃; for 2h; Inert atmosphere;
Stage #2: carbon dioxide In tetrahydrofuran at -70 - -50℃; for 1h;
(+/-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropane-1-ol

(+/-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropane-1-ol

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C
2.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
3.1: isopropyl alcohol / 15 h / 25 - 86 °C
4.1: sodium hydroxide / water
5.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
5.2: 1 h / -65 - -60 °C
View Scheme
Multi-step reaction with 6 steps
1.1: dmap; triethylamine / dichloromethane / 20 °C
2.1: potassium iodide / acetonitrile / 15 h / Reflux
3.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / Reflux
3.2: 1 h / -60 - -25 °C
3.3: 1 h / 0 - 20 °C
4.1: ammonia / ethyl acetate; water / pH 8 - 9
5.1: methanol / 50 - 65 °C
6.1: ammonia / water / pH 8 - 9
View Scheme
Multi-step reaction with 4 steps
1.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C
2.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere
3.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
3.2: 1.5 h / -70 - -60 °C / Inert atmosphere
3.3: -10 - 25 °C
4.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
4.2: 10 - 15 °C
View Scheme
(+/-)-N,N-diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropylamine

(+/-)-N,N-diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropylamine

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: isopropyl alcohol / 15 h / 25 - 86 °C
2.1: sodium hydroxide / water
3.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
3.2: 1 h / -65 - -60 °C
View Scheme
Multi-step reaction with 4 steps
1.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / Reflux
1.2: 1 h / -60 - -25 °C
1.3: 1 h / 0 - 20 °C
2.1: ammonia / ethyl acetate; water / pH 8 - 9
3.1: methanol / 50 - 65 °C
4.1: ammonia / water / pH 8 - 9
View Scheme
Multi-step reaction with 2 steps
1.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
1.2: 1.5 h / -70 - -60 °C / Inert atmosphere
1.3: -10 - 25 °C
2.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
2.2: 10 - 15 °C
View Scheme
4-bromo-phenol
106-41-2

4-bromo-phenol

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sulfuric acid / 120 - 125 °C
2.1: potassium carbonate; sodium iodide / acetone / Reflux
3.1: sodium tetrahydroborate / 1,2-dimethoxyethane / 0.17 h
3.2: 3 h / 10 °C
4.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C
5.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
6.1: isopropyl alcohol / 15 h / 25 - 86 °C
7.1: sodium hydroxide / water
8.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
8.2: 1 h / -65 - -60 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sulfuric acid / 12 h / 120 - 125 °C
2.1: potassium carbonate; sodium iodide / acetone / 25 - 30 °C
2.2: 5.5 h / 15 °C / Reflux
3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 4 h / 5 - 10 °C / Inert atmosphere
4.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C
5.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere
6.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
6.2: 1.5 h / -70 - -60 °C / Inert atmosphere
6.3: -10 - 25 °C
7.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
7.2: 10 - 15 °C
View Scheme
6-bromo-4-phenyl-3,4-dihydro-2H-chromen-2-one
156755-23-6

6-bromo-4-phenyl-3,4-dihydro-2H-chromen-2-one

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium carbonate; sodium iodide / acetone / Reflux
2.1: sodium tetrahydroborate / 1,2-dimethoxyethane / 0.17 h
2.2: 3 h / 10 °C
3.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C
4.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
5.1: isopropyl alcohol / 15 h / 25 - 86 °C
6.1: sodium hydroxide / water
7.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
7.2: 1 h / -65 - -60 °C
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate; sodium iodide / acetone / 25 - 30 °C
1.2: 5.5 h / 15 °C / Reflux
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 4 h / 5 - 10 °C / Inert atmosphere
3.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C
4.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere
5.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
5.2: 1.5 h / -70 - -60 °C / Inert atmosphere
5.3: -10 - 25 °C
6.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
6.2: 10 - 15 °C
View Scheme
Multi-step reaction with 8 steps
1.1: potassium carbonate / 60 - 65 °C
2.1: sodium hydroxide / water / 45 - 50 °C
3.1: ethanol / 5.83 h / 0 - 75 °C
4.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
5.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
6.1: toluene / 1 h / 0 - 35 °C
7.1: tetrahydrofuran / 4.5 h / 60 - 65 °C
8.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
8.2: 1 h / -70 - -50 °C
View Scheme
Multi-step reaction with 8 steps
1.1: potassium carbonate / 60 - 65 °C
2.1: sodium hydroxide / water / 45 - 50 °C
3.1: ethanol / 5.83 h / 0 - 75 °C
4.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
5.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
6.1: toluene / 1 h / 0 - 35 °C
7.1: iodine; lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 65 °C
8.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
8.2: 1 h / -70 - -50 °C
View Scheme
methyl 3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoate
156755-24-7

methyl 3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoate

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate / 1,2-dimethoxyethane / 0.17 h
1.2: 3 h / 10 °C
2.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C
3.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
4.1: isopropyl alcohol / 15 h / 25 - 86 °C
5.1: sodium hydroxide / water
6.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
6.2: 1 h / -65 - -60 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 4 h / 5 - 10 °C / Inert atmosphere
2.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C
3.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere
4.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
4.2: 1.5 h / -70 - -60 °C / Inert atmosphere
4.3: -10 - 25 °C
5.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
5.2: 10 - 15 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sodium hydroxide / water / 45 - 50 °C
2.1: ethanol / 5.83 h / 0 - 75 °C
3.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
4.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
5.1: toluene / 1 h / 0 - 35 °C
6.1: tetrahydrofuran / 4.5 h / 60 - 65 °C
7.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
7.2: 1 h / -70 - -50 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sodium hydroxide / water / 45 - 50 °C
2.1: ethanol / 5.83 h / 0 - 75 °C
3.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
4.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
5.1: toluene / 1 h / 0 - 35 °C
6.1: iodine; lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 65 °C
7.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
7.2: 1 h / -70 - -50 °C
View Scheme
(+/-)-toluene-4-sulphonic acid 3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl ester
250214-37-0

(+/-)-toluene-4-sulphonic acid 3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl ester

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
2.1: isopropyl alcohol / 15 h / 25 - 86 °C
3.1: sodium hydroxide / water
4.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
4.2: 1 h / -65 - -60 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium iodide / acetonitrile / 15 h / Reflux
2.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / Reflux
2.2: 1 h / -60 - -25 °C
2.3: 1 h / 0 - 20 °C
3.1: ammonia / ethyl acetate; water / pH 8 - 9
4.1: methanol / 50 - 65 °C
5.1: ammonia / water / pH 8 - 9
View Scheme
Multi-step reaction with 3 steps
1.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere
2.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
2.2: 1.5 h / -70 - -60 °C / Inert atmosphere
2.3: -10 - 25 °C
3.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
3.2: 10 - 15 °C
View Scheme
C20H18O8*C28H34BrNO
1135493-18-3

C20H18O8*C28H34BrNO

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide / water
2.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
2.2: 1 h / -65 - -60 °C
View Scheme
(-)-N,N-Diisopropyl-3-(2-benzyloxy-5-carboxyphenyl)-3-phenylpropylamine hydrochloride

(-)-N,N-Diisopropyl-3-(2-benzyloxy-5-carboxyphenyl)-3-phenylpropylamine hydrochloride

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ammonia / ethyl acetate; water / pH 8 - 9
2: methanol / 50 - 65 °C
3: ammonia / water / pH 8 - 9
View Scheme
(+)-N,N-Diisopropyl-3-(2-benzyloxy-5-carboxyphenyl)-3-phenylpropylamine

(+)-N,N-Diisopropyl-3-(2-benzyloxy-5-carboxyphenyl)-3-phenylpropylamine

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanol / 50 - 65 °C
2: ammonia / water / pH 8 - 9
View Scheme
Stage #1: (+)-N,N-Diisopropyl-3-(2-benzyloxy-5-carboxyphenyl)-3-phenylpropylamine With D-tartaric acid In isopropyl alcohol at 30 - 35℃; for 16h;
Stage #2: With water; sodium hydroxide In dichloromethane at 10 - 15℃;
(-)-N,N-diisopropyl-3-(2-benzyloxy-5-carboxyphenyl)-3-phenylpropylamine (-)-di-p-toluoyl-L-tartaric acid
1350477-43-8

(-)-N,N-diisopropyl-3-(2-benzyloxy-5-carboxyphenyl)-3-phenylpropylamine (-)-di-p-toluoyl-L-tartaric acid

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
With ammonia In water pH=8 - 9;
(+)-N,N-diisopropyl-3-(2-benzyloxy-5-carboxyphenyl)-3-phenylpropylamine
760147-33-9

(+)-N,N-diisopropyl-3-(2-benzyloxy-5-carboxyphenyl)-3-phenylpropylamine

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium hydroxide / dimethyl sulfoxide / 5.5 h / 110 - 120 °C
2: methanol / 50 - 65 °C
3: ammonia / water / pH 8 - 9
View Scheme
Cinnamic acid
621-82-9

Cinnamic acid

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sulfuric acid / 12 h / 120 - 125 °C
2.1: potassium carbonate; sodium iodide / acetone / 25 - 30 °C
2.2: 5.5 h / 15 °C / Reflux
3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 4 h / 5 - 10 °C / Inert atmosphere
4.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C
5.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere
6.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
6.2: 1.5 h / -70 - -60 °C / Inert atmosphere
6.3: -10 - 25 °C
7.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
7.2: 10 - 15 °C
View Scheme
R-(-)3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid
865889-33-4

R-(-)3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
2.1: toluene / 1 h / 0 - 35 °C
3.1: tetrahydrofuran / 4.5 h / 60 - 65 °C
4.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
4.2: 1 h / -70 - -50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
2.1: toluene / 1 h / 0 - 35 °C
3.1: iodine; lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 65 °C
4.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
4.2: 1 h / -70 - -50 °C
View Scheme
(3R)-3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoyl chloride
1429299-07-9

(3R)-3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoyl chloride

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene / 1 h / 0 - 35 °C
2.1: tetrahydrofuran / 4.5 h / 60 - 65 °C
3.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
3.2: 1 h / -70 - -50 °C
View Scheme
Multi-step reaction with 3 steps
1.1: toluene / 1 h / 0 - 35 °C
2.1: iodine; lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 65 °C
3.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
3.2: 1 h / -70 - -50 °C
View Scheme
R-(-)-N,N-diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionamide
1429299-08-0

R-(-)-N,N-diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionamide

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: iodine; lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 65 °C
2.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
2.2: 1 h / -70 - -50 °C
View Scheme
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 4.5 h / 60 - 65 °C
2.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
2.2: 1 h / -70 - -50 °C
View Scheme
benzyl chloride
100-44-7

benzyl chloride

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: potassium carbonate / 60 - 65 °C
2.1: sodium hydroxide / water / 45 - 50 °C
3.1: ethanol / 5.83 h / 0 - 75 °C
4.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
5.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
6.1: toluene / 1 h / 0 - 35 °C
7.1: tetrahydrofuran / 4.5 h / 60 - 65 °C
8.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
8.2: 1 h / -70 - -50 °C
View Scheme
Multi-step reaction with 8 steps
1.1: potassium carbonate / 60 - 65 °C
2.1: sodium hydroxide / water / 45 - 50 °C
3.1: ethanol / 5.83 h / 0 - 75 °C
4.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
5.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
6.1: toluene / 1 h / 0 - 35 °C
7.1: iodine; lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 65 °C
8.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
8.2: 1 h / -70 - -50 °C
View Scheme
(+/-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid
1185739-54-1

(+/-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: ethanol / 5.83 h / 0 - 75 °C
2.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
4.1: toluene / 1 h / 0 - 35 °C
5.1: tetrahydrofuran / 4.5 h / 60 - 65 °C
6.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
6.2: 1 h / -70 - -50 °C
View Scheme
Multi-step reaction with 6 steps
1.1: ethanol / 5.83 h / 0 - 75 °C
2.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
4.1: toluene / 1 h / 0 - 35 °C
5.1: iodine; lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 65 °C
6.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
6.2: 1 h / -70 - -50 °C
View Scheme
R-(-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1S,2R)-ephedrine salt
1429299-06-8

R-(-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1S,2R)-ephedrine salt

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
3.1: toluene / 1 h / 0 - 35 °C
4.1: tetrahydrofuran / 4.5 h / 60 - 65 °C
5.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
5.2: 1 h / -70 - -50 °C
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
3.1: toluene / 1 h / 0 - 35 °C
4.1: iodine; lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 65 °C
5.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
5.2: 1 h / -70 - -50 °C
View Scheme
methanol
67-56-1

methanol

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

methyl 4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoate
156755-35-0

methyl 4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoate

Conditions
ConditionsYield
With sulfuric acid at 20℃; Product distribution / selectivity; Reflux;
With thionyl chloride at 0 - 65℃;64 g
4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol
207679-81-0

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid / 20 °C / Reflux
2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / Inert atmosphere
3: hydrogen / Raney nickel / methanol / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 30 - 55 °C
1.2: 0.33 h / 0 - 5 °C
2.1: hydrogen / Raney nickel / methanol / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: thionyl chloride / 0 - 65 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 30 °C
3: hydrogen; palladium 10% on activated carbon / isopropyl alcohol / 25 - 30 °C / 2068.65 - 2585.81 Torr / Autoclave
View Scheme
4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

fesoterodine
286930-02-7

fesoterodine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid / 20 °C / Reflux
2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / Inert atmosphere
3: hydrogen / Raney nickel / methanol / 20 °C
4: triethylamine / acetonitrile / -10 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 30 - 55 °C
1.2: 0.33 h / 0 - 5 °C
2.1: hydrogen / Raney nickel / methanol / 20 °C
3.1: triethylamine / acetonitrile / -10 °C
View Scheme
Multi-step reaction with 4 steps
1: thionyl chloride / 0 - 65 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 30 °C
3: hydrogen; palladium 10% on activated carbon / isopropyl alcohol / 25 - 30 °C / 2068.65 - 2585.81 Torr / Autoclave
4: sodium hydrogencarbonate / dichloromethane / 3 h / -2 - 3 °C
View Scheme
4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

{4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol
156755-37-2

{4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol

Conditions
ConditionsYield
Stage #1: 4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene at 30 - 55℃;
Stage #2: With water; sodium hydroxide In toluene at 0 - 5℃; for 0.333333h;
Multi-step reaction with 2 steps
1: sulfuric acid / 20 °C / Reflux
2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / Inert atmosphere
View Scheme
4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

fesoterodine fumarate

fesoterodine fumarate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sulfuric acid / 20 °C / Reflux
2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / Inert atmosphere
3: hydrogen / Raney nickel / methanol / 20 °C
4: triethylamine / acetonitrile / -10 °C
5: butanone / -5 °C / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 30 - 55 °C
1.2: 0.33 h / 0 - 5 °C
2.1: hydrogen / Raney nickel / methanol / 20 °C
3.1: triethylamine / acetonitrile / -10 °C
4.1: butanone / -5 °C / Heating
View Scheme
4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Tolterodine acid
194482-44-5

Tolterodine acid

Conditions
ConditionsYield
With hydrogen; 5%-palladium/activated carbon In methanol at 25 - 30℃; under 2206.72 - 2942.29 Torr; for 8h; autoclave;
4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxyl-methyl)phenyl isobutyrate

2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxyl-methyl)phenyl isobutyrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 25 - 30 °C / 2206.72 - 2942.29 Torr / autoclave
2.1: chloroform / 0.75 h / -45 - -35 °C
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 6 h / 25 - 30 °C / 2206.72 - 2942.29 Torr / autoclave
3.2: 1 h / 0 - 5 °C
3.3: 7.5 h / 0 - 30 °C
View Scheme
4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

(R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid
1390644-41-3

(R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 25 - 30 °C / 2206.72 - 2942.29 Torr / autoclave
2: chloroform / 0.75 h / -45 - -35 °C
View Scheme
4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid
754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

2-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate fumarate

2-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate fumarate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: thionyl chloride / 0 - 65 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 30 °C
3: hydrogen; palladium 10% on activated carbon / isopropyl alcohol / 25 - 30 °C / 2068.65 - 2585.81 Torr / Autoclave
4: sodium hydrogencarbonate / dichloromethane / 3 h / -2 - 3 °C
5: butanone; cyclohexane / 20 - 36 °C
View Scheme

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