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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Enalapril

Cas:75847-73-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Enalapril 75847-73-3

Cas:75847-73-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

Specification: USP30. CAS RN.: 75847-73-3 Molecular Weight: 376.4467 Molecular Formula:

Enalapril 75847-73-3

Cas:75847-73-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Enalapril

Cas:75847-73-3

Min.Order:5 Milligram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Enalapril

Cas:75847-73-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Enalapril The alias:4ENALAPRIL;(s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline CAS NO:75847-73-3 Molecular formula:C20H28N2O5 Molecular weight:376.4467 Product Quality 12 years of chemical raw materials Mature operati

Enalapril/CAS:75847-73-3/with best price

Cas:75847-73-3

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 75847-73-3 with best quality

Cas:75847-73-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Enalapril Basic information Product Name: Enalapril Synonyms: (s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline;1-(n-((s)-1-carboxy-3-phenylpropyl)-l

Enalapril

Cas:75847-73-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Enalapril 99%

Cas:75847-73-3

Min.Order:1 Kilogram

FOB Price: $45.0 / 56.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Enalapril

Cas:75847-73-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

L-Proline,N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-

Cas:75847-73-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High Quality Enalapril CAS NO.75847-73-3

Cas:75847-73-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ENALAPRIL

Cas:75847-73-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

Enalapril CAS 75847-73-3 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Pro

Enalapril CAS 75847-73-3

Cas:75847-73-3

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Enalapril

Cas:75847-73-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Manufacturer/High quality Enalapril 75847-73-3

Cas:75847-73-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

L-Proline,N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-

Cas:75847-73-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Enalapril CAS 75847-73-3 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system

Enalapril CAS 75847-73-3

Cas:75847-73-3

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Enalapril

Cas:75847-73-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Enalapril Synonyms: (s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline;1-(n-((s)-1-carboxy-3-phenylpropyl)-l-alanyl)-l-proline 1'-ethyl ester;1-[2-(1-ETHOXYCARBONYL-3-PHENYL-PROPYL)AMINOPROPANOYL]PYRROLIDINE-2

TIANFU-CHEM--Enalapril

Cas:75847-73-3

Min.Order:1 Kilogram

FOB Price: $1300.0

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

Antihypertensive 99% cas 75847-73-3 Enalapril Powder Name Enalapril CAS NO. 75847-73-3 Purity 99% Grade Standard Medical Standard Sample Available MW 376.45 Test Method HPLC Appearance White Powder Appearance:wh

Antihypertensive 99% cas 75847-73-3 Enalapril Powder

Cas:75847-73-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Enalapril

Cas:75847-73-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

High Quality Enalapril CAS NO.75847-73-3

Cas:75847-73-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

High Quality Enalapril CAS NO.75847-73-3

Cas:75847-73-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

High Quality Enalapril CAS NO.75847-73-3

Cas:75847-73-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Enalapril

Cas:75847-73-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

High Quality Enalapril CAS NO.75847-73-3

Cas:75847-73-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Research Peptide Biotechnology Co., Ltd.

High purity, high success rate, short cycle and moderate priceAppearance:White powder solid Storage:Negative 20 degrees Celsius Package:5mg, 10mg 100mg, 1gram Application:Applied to various scientific research

L-Proline,N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-

Cas:75847-73-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Enalapril

Cas:75847-73-3

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Enalapril

Cas:75847-73-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

N-succinimidyl (2S)-2-{N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propionate
89371-34-6

N-succinimidyl (2S)-2-{N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propionate

L-proline
147-85-3

L-proline

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
With triethylamine In ethanol; water for 16h; Ambient temperature;92.9%
N--L-alanyl>-L-proline tert butyl ester
108428-39-3

N--L-alanyl>-L-proline tert butyl ester

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
With trifluoroacetic acid for 3h; Ambient temperature;85%
With hydrogenchloride In ethyl acetate
2-oxo-4-phenylbutanoic acid ethyl ester
64920-29-2

2-oxo-4-phenylbutanoic acid ethyl ester

L-alanyl-L-proline
13485-59-1

L-alanyl-L-proline

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
With hydrogen In ethanol at 45℃; under 735.074 - 772.577 Torr; Catalytic behavior; Kinetics; Solvent; Reagent/catalyst;70%
L-alanyl-L-proline
13485-59-1

L-alanyl-L-proline

(E)-ethyl-2-oxo-4-phenylbut-3-enoate
17451-20-6, 55674-14-1, 55629-96-4

(E)-ethyl-2-oxo-4-phenylbut-3-enoate

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
With 4 A molecular sieve; hydrogen; triethylamine; palladium In ethanol at 20℃; for 44h;65%
2-oxo-4-phenylbutanoic acid ethyl ester
64920-29-2

2-oxo-4-phenylbutanoic acid ethyl ester

L-alanyl-L-proline
13485-59-1

L-alanyl-L-proline

A

enalapril
75847-73-3

enalapril

B

enalapril
76420-74-1

enalapril

Conditions
ConditionsYield
nickel Product distribution; var. catalysts and reducing agents, diastereomeric ratio;
With 3 A molecular sieve; hydrogen; nickel In ethanol at 23 - 28℃; under 2068.6 Torr; for 18h; Title compound not separated from byproducts;
With potassium fluoride; 3 A molecular sieve; hydrogen; acetic acid; nickel In ethanol at 22℃; under 760 Torr; for 18h; Yield given; Yields of byproduct given;
N-<(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl>-L-alanyl-L-proline Benzylester
120924-94-9

N-<(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl>-L-alanyl-L-proline Benzylester

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol under 735.5 Torr; for 2h; Ambient temperature; Yield given;
With palladium 10% on activated carbon; hydrogen In methanol at 15 - 20℃;
L-proline
147-85-3

L-proline

C18H26N2O4
406213-94-3

C18H26N2O4

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; acetonitrile at 20℃; for 8h;
[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine
82717-96-2

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: HCl / CH2Cl2; dioxane / -5 - 0 °C
1.2: ClCOCOCl / dimethylformamide; CH2Cl2; dioxane / -5 - 0 °C
2.1: dimethylformamide; CH2Cl2; dioxane / 1 h / 20 °C
3.1: DBU / acetonitrile; CH2Cl2 / 8 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 86 percent / NaHCO3, diphenylchlorophosphate / acetone / 1 h / 50 °C
2: 92.9 percent / Et3N / ethanol; H2O / 16 h / Ambient temperature
View Scheme
N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride
103377-40-8

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethylformamide; CH2Cl2; dioxane / 1 h / 20 °C
2: DBU / acetonitrile; CH2Cl2 / 8 h / 20 °C
View Scheme
3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

sodium-

sodium-

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 45 percent / methanol; H2O / 8 h / 70 °C
2: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9
3: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h
4: 95 percent / SOCl2 / 24 h / Ambient temperature
5: 74 percent / (NH4)2CO3 / nitromethane; H2O / 96 h / 50 °C
6: 85 percent / TFA / 3 h / Ambient temperature
View Scheme
5-phenylethyl-imidazolidine-2,4-dione
120379-81-9

5-phenylethyl-imidazolidine-2,4-dione

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9
2: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h
3: 95 percent / SOCl2 / 24 h / Ambient temperature
4: 74 percent / (NH4)2CO3 / nitromethane; H2O / 96 h / 50 °C
5: 85 percent / TFA / 3 h / Ambient temperature
View Scheme
(R)-2-bromo-4-phenylbutyric acid
121842-76-0

(R)-2-bromo-4-phenylbutyric acid

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / SOCl2 / 24 h / Ambient temperature
2: 74 percent / (NH4)2CO3 / nitromethane; H2O / 96 h / 50 °C
3: 85 percent / TFA / 3 h / Ambient temperature
View Scheme
(R)-ethyl 2-bromo-4-phenylbutyrate
121842-77-1

(R)-ethyl 2-bromo-4-phenylbutyrate

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 74 percent / (NH4)2CO3 / nitromethane; H2O / 96 h / 50 °C
2: 85 percent / TFA / 3 h / Ambient temperature
View Scheme
N-carbamyl (R)-2-amino-4-phenylbutyric acid
121842-75-9

N-carbamyl (R)-2-amino-4-phenylbutyric acid

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h
2: 95 percent / SOCl2 / 24 h / Ambient temperature
3: 74 percent / (NH4)2CO3 / nitromethane; H2O / 96 h / 50 °C
4: 85 percent / TFA / 3 h / Ambient temperature
View Scheme
2-oxo-4-phenylbutanoic acid ethyl ester
64920-29-2

2-oxo-4-phenylbutanoic acid ethyl ester

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 29 percent / H2, AcONa, AcOH, molecular sieves 3A / Raney Ni / ethanol
2: 93 percent / HCl / H2O / 4 h
3: 67 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 1 h
4: HCl / ethyl acetate
View Scheme
proline tert-butyl ester
2812-46-6

proline tert-butyl ester

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 67 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 1 h
2: HCl / ethyl acetate
View Scheme
N-<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-alanine tert-butylester
80828-38-2

N-<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-alanine tert-butylester

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 93 percent / HCl / H2O / 4 h
2: 67 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 1 h
3: HCl / ethyl acetate
View Scheme
N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine hydrochloride
80828-26-8

N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine hydrochloride

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 67 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 1 h
2: HCl / ethyl acetate
View Scheme
Multi-step reaction with 2 steps
1.1: (chloromethylene)dimethyliminium chloride / dichloromethane / 0.67 h / -10 - -5 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: hydrogen; palladium 10% on activated carbon / methanol / 15 - 20 °C
View Scheme
N-<(2R)-2-(4-Toluenesulfonyloxy)propionyl>-L-proline Benzylester
136622-17-8

N-<(2R)-2-(4-Toluenesulfonyloxy)propionyl>-L-proline Benzylester

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 76 percent / Et3N / dimethylsulfoxide / 8 h / 75 °C
2: hydrogen / 10percent Pd/C / ethanol / 2 h / 735.5 Torr / Ambient temperature
View Scheme
N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride
84793-24-8

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride

L-proline
147-85-3

L-proline

A

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine
82717-96-2

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine

B

enalaprilate
76420-72-9

enalaprilate

C

enalapril
75847-73-3

enalapril

D

(S)-2-((3S,8aS)-3-Methyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-4-phenyl-butyric acid ethyl ester
115729-52-7

(S)-2-((3S,8aS)-3-Methyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-4-phenyl-butyric acid ethyl ester

Conditions
ConditionsYield
Stage #1: N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride; L-proline In water; ethyl acetate at 19 - 20℃; for 5h; pH=10 - 11;
Stage #2: at 30℃; for 0.166667h; pH=4.3 - 4.7;
A 0.5 %Chromat.
B 0.4 %Chromat.
C 14 %Chromat.
D 0.5 %Chromat.
Stage #1: N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride; L-proline In dichloromethane; water at 19 - 20℃; for 5h; pH=9.5 - 11.5;
Stage #2: at 30℃; for 0.166667h; pH=4.3 - 4.7;
A 0.5 %Chromat.
B 0.5 %Chromat.
C 10 %Chromat.
D 0.6 %Chromat.
Stage #1: N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride; L-proline In water; ethyl acetate at 19 - 20℃; for 5h; pH=9.5 - 11.5;
Stage #2: at 30℃; for 0.166667h; pH=4.3 - 4.7;
A 0.6 %Chromat.
B 0.5 %Chromat.
C 14 %Chromat.
D 0.4 %Chromat.
[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine
82717-96-2

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine

L-proline
147-85-3

L-proline

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In DMF (N,N-dimethyl-formamide); acetonitrile at 20℃; for 0.5h;
aqueous pyridine

aqueous pyridine

L-alanyl-D-proline TFA salt

L-alanyl-D-proline TFA salt

2-oxo-4-phenylbutanoic acid ethyl ester
64920-29-2

2-oxo-4-phenylbutanoic acid ethyl ester

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
With sodium cyanoborohydride; triethylamine In ethanol; water
2-oxo-4-phenylbutanoic acid ethyl ester
64920-29-2

2-oxo-4-phenylbutanoic acid ethyl ester

L-alanyl-L-proline
13485-59-1

L-alanyl-L-proline

A

nitric salt

nitric salt

B

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
aluminum nickel; silica gel In ethanol; acetic acid methyl ester; water; ethyl acetate
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride
16652-71-4

benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: (chloromethylene)dimethyliminium chloride / dichloromethane / 0.67 h / -10 - -5 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: hydrogen; palladium 10% on activated carbon / methanol / 15 - 20 °C
View Scheme
C20H26N2O6

C20H26N2O6

enalapril
75847-73-3

enalapril

Conditions
ConditionsYield
With sulfuric acid; palladium on activated charcoal; hydrogen for 1h; Large scale;
enalapril
75847-73-3

enalapril

enalapril sodium salt
149404-21-7

enalapril sodium salt

Conditions
ConditionsYield
With sodium methylate In methanol100%
enalapril
75847-73-3

enalapril

maleic acid
110-16-7

maleic acid

Amprace
76095-16-4

Amprace

Conditions
ConditionsYield
at 5 - 30℃; for 7h;92%
at 30 - 50℃; for 6h;90%
In water at 5 - 60℃; for 4h;90%
enalapril
75847-73-3

enalapril

enalaprilate
76420-72-9

enalaprilate

Conditions
ConditionsYield
With sodium hydroxide for 24h; Ambient temperature;75%
at 37℃; esterase from various rat tissue homogenates or plasma;
With recombinant human carboxylesterase 1; water In aq. phosphate buffer at 37℃; for 0.333333h; Kinetics; Enzymatic reaction;
enalapril
75847-73-3

enalapril

(S)-2-((3S,8aS)-3-Methyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-4-phenyl-butyric acid ethyl ester
115729-52-7

(S)-2-((3S,8aS)-3-Methyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-4-phenyl-butyric acid ethyl ester

Conditions
ConditionsYield
In xylene for 5h; Heating;60%
enalapril
75847-73-3

enalapril

(R)-2-((3S,8aR)-3-Methyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-4-phenyl-butyric acid

(R)-2-((3S,8aR)-3-Methyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-4-phenyl-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 60 percent / xylene / 5 h / Heating
2: tetramethylammonium hydroxide / ethanol / 2 h
View Scheme
enalapril
75847-73-3

enalapril

(S)-2-((3S,8aR)-3-Methyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-4-phenyl-butyric acid

(S)-2-((3S,8aR)-3-Methyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-4-phenyl-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 60 percent / xylene / 5 h / Heating
2: tetramethylammonium hydroxide / ethanol / 2 h
View Scheme
enalapril
75847-73-3

enalapril

enalaprilic acid

enalaprilic acid

Conditions
ConditionsYield
In sodium hydroxide
In sodium hydroxide

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