As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:75847-73-3
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inquirySpecification: USP30. CAS RN.: 75847-73-3 Molecular Weight: 376.4467 Molecular Formula:
ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Enalapril The alias:4ENALAPRIL;(s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline CAS NO:75847-73-3 Molecular formula:C20H28N2O5 Molecular weight:376.4467 Product Quality 12 years of chemical raw materials Mature operati
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:75847-73-3
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inquiryEnalapril Basic information Product Name: Enalapril Synonyms: (s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline;1-(n-((s)-1-carboxy-3-phenylpropyl)-l
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:75847-73-3
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:75847-73-3
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Enalapril CAS 75847-73-3 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Pro
Cas:75847-73-3
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be
Cas:75847-73-3
Min.Order:1 Gram
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:75847-73-3
Min.Order:0
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Type:Lab/Research institutions
inquiryEnalapril CAS 75847-73-3 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system
Cas:75847-73-3
Min.Order:1 Kilogram
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Type:Trading Company
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product Name: Enalapril Synonyms: (s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline;1-(n-((s)-1-carboxy-3-phenylpropyl)-l-alanyl)-l-proline 1'-ethyl ester;1-[2-(1-ETHOXYCARBONYL-3-PHENYL-PROPYL)AMINOPROPANOYL]PYRROLIDINE-2
Cas:75847-73-3
Min.Order:1 Kilogram
FOB Price: $1300.0
Type:Lab/Research institutions
inquiryAntihypertensive 99% cas 75847-73-3 Enalapril Powder Name Enalapril CAS NO. 75847-73-3 Purity 99% Grade Standard Medical Standard Sample Available MW 376.45 Test Method HPLC Appearance White Powder Appearance:wh
Cas:75847-73-3
Min.Order:1 Kilogram
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Type:Trading Company
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:75847-73-3
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:75847-73-3
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:75847-73-3
Min.Order:1 Metric Ton
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Type:Trading Company
inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:75847-73-3
Min.Order:1 Metric Ton
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Type:Trading Company
inquiryHigh purity, high success rate, short cycle and moderate priceAppearance:White powder solid Storage:Negative 20 degrees Celsius Package:5mg, 10mg 100mg, 1gram Application:Applied to various scientific research
Cas:75847-73-3
Min.Order:0
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Type:Lab/Research institutions
inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier
N-succinimidyl (2S)-2-{N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propionate
L-proline
enalapril
Conditions | Yield |
---|---|
With triethylamine In ethanol; water for 16h; Ambient temperature; | 92.9% |
N--L-alanyl>-L-proline tert butyl ester
enalapril
Conditions | Yield |
---|---|
With trifluoroacetic acid for 3h; Ambient temperature; | 85% |
With hydrogenchloride In ethyl acetate |
2-oxo-4-phenylbutanoic acid ethyl ester
L-alanyl-L-proline
enalapril
Conditions | Yield |
---|---|
With hydrogen In ethanol at 45℃; under 735.074 - 772.577 Torr; Catalytic behavior; Kinetics; Solvent; Reagent/catalyst; | 70% |
L-alanyl-L-proline
(E)-ethyl-2-oxo-4-phenylbut-3-enoate
enalapril
Conditions | Yield |
---|---|
With 4 A molecular sieve; hydrogen; triethylamine; palladium In ethanol at 20℃; for 44h; | 65% |
2-oxo-4-phenylbutanoic acid ethyl ester
L-alanyl-L-proline
A
enalapril
B
enalapril
Conditions | Yield |
---|---|
nickel Product distribution; var. catalysts and reducing agents, diastereomeric ratio; | |
With 3 A molecular sieve; hydrogen; nickel In ethanol at 23 - 28℃; under 2068.6 Torr; for 18h; Title compound not separated from byproducts; | |
With potassium fluoride; 3 A molecular sieve; hydrogen; acetic acid; nickel In ethanol at 22℃; under 760 Torr; for 18h; Yield given; Yields of byproduct given; |
N-<(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl>-L-alanyl-L-proline Benzylester
enalapril
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethanol under 735.5 Torr; for 2h; Ambient temperature; Yield given; | |
With palladium 10% on activated carbon; hydrogen In methanol at 15 - 20℃; |
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; acetonitrile at 20℃; for 8h; |
[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: HCl / CH2Cl2; dioxane / -5 - 0 °C 1.2: ClCOCOCl / dimethylformamide; CH2Cl2; dioxane / -5 - 0 °C 2.1: dimethylformamide; CH2Cl2; dioxane / 1 h / 20 °C 3.1: DBU / acetonitrile; CH2Cl2 / 8 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 86 percent / NaHCO3, diphenylchlorophosphate / acetone / 1 h / 50 °C 2: 92.9 percent / Et3N / ethanol; H2O / 16 h / Ambient temperature View Scheme |
N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dimethylformamide; CH2Cl2; dioxane / 1 h / 20 °C 2: DBU / acetonitrile; CH2Cl2 / 8 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 45 percent / methanol; H2O / 8 h / 70 °C 2: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9 3: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h 4: 95 percent / SOCl2 / 24 h / Ambient temperature 5: 74 percent / (NH4)2CO3 / nitromethane; H2O / 96 h / 50 °C 6: 85 percent / TFA / 3 h / Ambient temperature View Scheme |
5-phenylethyl-imidazolidine-2,4-dione
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9 2: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h 3: 95 percent / SOCl2 / 24 h / Ambient temperature 4: 74 percent / (NH4)2CO3 / nitromethane; H2O / 96 h / 50 °C 5: 85 percent / TFA / 3 h / Ambient temperature View Scheme |
(R)-2-bromo-4-phenylbutyric acid
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 95 percent / SOCl2 / 24 h / Ambient temperature 2: 74 percent / (NH4)2CO3 / nitromethane; H2O / 96 h / 50 °C 3: 85 percent / TFA / 3 h / Ambient temperature View Scheme |
(R)-ethyl 2-bromo-4-phenylbutyrate
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 74 percent / (NH4)2CO3 / nitromethane; H2O / 96 h / 50 °C 2: 85 percent / TFA / 3 h / Ambient temperature View Scheme |
N-carbamyl (R)-2-amino-4-phenylbutyric acid
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h 2: 95 percent / SOCl2 / 24 h / Ambient temperature 3: 74 percent / (NH4)2CO3 / nitromethane; H2O / 96 h / 50 °C 4: 85 percent / TFA / 3 h / Ambient temperature View Scheme |
2-oxo-4-phenylbutanoic acid ethyl ester
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 29 percent / H2, AcONa, AcOH, molecular sieves 3A / Raney Ni / ethanol 2: 93 percent / HCl / H2O / 4 h 3: 67 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 1 h 4: HCl / ethyl acetate View Scheme |
proline tert-butyl ester
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 67 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 1 h 2: HCl / ethyl acetate View Scheme |
N-<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-alanine tert-butylester
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 93 percent / HCl / H2O / 4 h 2: 67 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 1 h 3: HCl / ethyl acetate View Scheme |
N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine hydrochloride
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 67 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 1 h 2: HCl / ethyl acetate View Scheme | |
Multi-step reaction with 2 steps 1.1: (chloromethylene)dimethyliminium chloride / dichloromethane / 0.67 h / -10 - -5 °C / Inert atmosphere 1.2: Inert atmosphere 2.1: hydrogen; palladium 10% on activated carbon / methanol / 15 - 20 °C View Scheme |
N-<(2R)-2-(4-Toluenesulfonyloxy)propionyl>-L-proline Benzylester
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 76 percent / Et3N / dimethylsulfoxide / 8 h / 75 °C 2: hydrogen / 10percent Pd/C / ethanol / 2 h / 735.5 Torr / Ambient temperature View Scheme |
N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride
L-proline
A
[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine
B
enalaprilate
C
enalapril
D
(S)-2-((3S,8aS)-3-Methyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-4-phenyl-butyric acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride; L-proline In water; ethyl acetate at 19 - 20℃; for 5h; pH=10 - 11; Stage #2: at 30℃; for 0.166667h; pH=4.3 - 4.7; | A 0.5 %Chromat. B 0.4 %Chromat. C 14 %Chromat. D 0.5 %Chromat. |
Stage #1: N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride; L-proline In dichloromethane; water at 19 - 20℃; for 5h; pH=9.5 - 11.5; Stage #2: at 30℃; for 0.166667h; pH=4.3 - 4.7; | A 0.5 %Chromat. B 0.5 %Chromat. C 10 %Chromat. D 0.6 %Chromat. |
Stage #1: N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride; L-proline In water; ethyl acetate at 19 - 20℃; for 5h; pH=9.5 - 11.5; Stage #2: at 30℃; for 0.166667h; pH=4.3 - 4.7; | A 0.6 %Chromat. B 0.5 %Chromat. C 14 %Chromat. D 0.4 %Chromat. |
[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine
L-proline
enalapril
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In DMF (N,N-dimethyl-formamide); acetonitrile at 20℃; for 0.5h; |
2-oxo-4-phenylbutanoic acid ethyl ester
enalapril
Conditions | Yield |
---|---|
With sodium cyanoborohydride; triethylamine In ethanol; water |
2-oxo-4-phenylbutanoic acid ethyl ester
L-alanyl-L-proline
B
enalapril
Conditions | Yield |
---|---|
aluminum nickel; silica gel In ethanol; acetic acid methyl ester; water; ethyl acetate |
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: (chloromethylene)dimethyliminium chloride / dichloromethane / 0.67 h / -10 - -5 °C / Inert atmosphere 1.2: Inert atmosphere 2.1: hydrogen; palladium 10% on activated carbon / methanol / 15 - 20 °C View Scheme |
enalapril
Conditions | Yield |
---|---|
With sulfuric acid; palladium on activated charcoal; hydrogen for 1h; Large scale; |
enalapril
enalapril sodium salt
Conditions | Yield |
---|---|
With sodium methylate In methanol | 100% |
Conditions | Yield |
---|---|
at 5 - 30℃; for 7h; | 92% |
at 30 - 50℃; for 6h; | 90% |
In water at 5 - 60℃; for 4h; | 90% |
enalapril
enalaprilate
Conditions | Yield |
---|---|
With sodium hydroxide for 24h; Ambient temperature; | 75% |
at 37℃; esterase from various rat tissue homogenates or plasma; | |
With recombinant human carboxylesterase 1; water In aq. phosphate buffer at 37℃; for 0.333333h; Kinetics; Enzymatic reaction; |
enalapril
(S)-2-((3S,8aS)-3-Methyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-4-phenyl-butyric acid ethyl ester
Conditions | Yield |
---|---|
In xylene for 5h; Heating; | 60% |
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 60 percent / xylene / 5 h / Heating 2: tetramethylammonium hydroxide / ethanol / 2 h View Scheme |
enalapril
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 60 percent / xylene / 5 h / Heating 2: tetramethylammonium hydroxide / ethanol / 2 h View Scheme |
enalapril
Conditions | Yield |
---|---|
In sodium hydroxide | |
In sodium hydroxide |
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