Hangzhou Think Chemical Co. Ltd
Solithromycin CAS No.:760981-83-7 Name: Solithromycin Synonyms: CEM 101; OP 1068 Molecular Structure: Molecular Formula: C43H65FN6O10 Molecular Weight: 845.01 CAS Reg
Cas:760981-83-7
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryHenan Tianfu Chemical Co., Ltd.
Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company
Cas:760981-83-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryZhuozhou Wenxi import and Export Co., Ltd
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:760981-83-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryHangzhou Sartort Biopharma Co., Ltd
Appearance:White to off-white powder Storage:R.T Package:25kg/Barrel Application:A new type of ketolactone (ie macrolide) antibiotic Transportation:Express/Sea/Air Port:Any port in China
Cas:760981-83-7
Min.Order:50 Gram
FOB Price: $20.0 / 60.0
Type:Lab/Research institutions
inquiryShanghai Upbio Tech Co.,Ltd
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:760981-83-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryLeader Biochemical Group
About Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:760981-83-7
Min.Order:100 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryBaoji Guokang Healthchem co.,ltd
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:760981-83-7
Min.Order:1 Gram
FOB Price: $48.0 / 60.0
Type:Trading Company
inquiryQingdao Beluga Import and Export Co., LTD
Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical
Cas:760981-83-7
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryShandong Hanjiang Chemical Co., Ltd.
Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:760981-83-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou JINLAN Pharm-Drugs Technology Co., Ltd
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:760981-83-7
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryHebei Quanhe Biotechnology Co. LTD
1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:760981-83-7
Min.Order:1 Kilogram
FOB Price: $50.0 / 100.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co., Ltd.
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Taizhou Crene Biotechnology co.ltd
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:760981-83-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryAfine Chemicals Limited
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Zibo Hangyu Biotechnology Development Co., Ltd
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:760981-83-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryZibo Dorne chemical technology co. LTD
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:760981-83-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryXiamen Jenny Chemical Technology Co., Ltd.
GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:760981-83-7
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiryEAST CHEMSOURCES LIMITED
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:760981-83-7
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryHangzhou Huarong Pharm Co., Ltd.
Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
Shandong Mopai Biotechnology Co., LTD
Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:760981-83-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryKAISA GROUP INC
1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:760981-83-7
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquirySenova Technology Company Limited
We have most reliable quality, competitive prices and full documents for this APIs 1. GMP WORKSHOP 2. DMF Application:Antibacteria
Wuhu Nuowei Chemistry Technologies Co., Ltd.
Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma
Bluecrystal chem-union
We are a Union of chemistry in China, consists of chemists，engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:760981-83-7
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Trading Company
inquiryHangzhou Dingyan Chem Co., Ltd
manufacture Application:The refence standard products, for lab use, also we could produce bigger quantity on yr requirement.
HANGZHOU YUNUO CHEMICAL CO.,LTD
Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is an impo
Cas:760981-83-7
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryBOC Sciences
BOC Sciences is committed to supplying cost-effective products and services. We provide Solithromycin. Solithromycin, also known as CEM-101 and OP-1068, is a ketolide antibiotic undergoing clinical development for the treatment of community-acquire
Hubei Taiho Chemical Co.,LTD
TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
Hangzhou J&H Chemical Co., Ltd.
J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
Synthetic route
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol; water at 40℃; for 24h; | 98% |
| With methanol at 40℃; | 97.7% |
| With methanol at 20℃; for 16h; | 0.2 g |
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| With Imidazole hydrochloride at 60℃; | 95% |
| Stage #1: C36H54FN3O12 at 23℃; under 0.1 Torr; for 12h; Stage #2: 1-(4-aminobutyl)-4-(3-aminophenyl)-1H-1,2,3-triazole With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 45℃; for 2h; | 79 mg |
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54060-30-9
3-acetylenephenylamine
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| With copper(II) sulfate; sodium L-ascorbate In water; tert-butyl alcohol for 16h; | 69% |
| With copper(l) iodide In toluene at 70℃; for 16h; | 17 mg |
| With copper(II) sulfate; sodium L-ascorbate In water; tert-butyl alcohol at 20℃; for 24h; | |
| With copper(II) sulfate; sodium L-ascorbate In water; tert-butyl alcohol at 20℃; for 24h; Reagent/catalyst; Huisgen Cycloaddition; |
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1.1: sodium azide / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere 2.1: hydrogenchloride / methanol; water / 20 h / 20 °C 3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere 3.2: 2 h / -78 - 20 °C / Inert atmosphere 4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 4.2: 2 h / 0 - 20 °C / Inert atmosphere 5.1: methanol / 3 h / Inert atmosphere; Reflux 6.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 24 h / 20 °C View Scheme |
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849407-73-4
C47H79N5O15
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1.1: hydrogenchloride / methanol; water / 20 h / 20 °C 2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere 2.2: 2 h / -78 - 20 °C / Inert atmosphere 3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 3.2: 2 h / 0 - 20 °C / Inert atmosphere 4.1: methanol / 3 h / Inert atmosphere; Reflux 5.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 24 h / 20 °C View Scheme |
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849407-74-5
acetic acid 2-[1-(4-azido-butyl)-4-ethyl-8-hydroxy-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy]-4-dimethylamino-6-methyl-tetrahydro-pyran-3-yl ester
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 - 20 °C / Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 2.2: 2 h / 0 - 20 °C / Inert atmosphere 3.1: methanol / 3 h / Inert atmosphere; Reflux 4.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 24 h / 20 °C View Scheme |
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760981-81-5
11-N-(4-azido-butyl)-6-O-methyl-5-(2-acetyl-desosamynyl)-3-oxo-erythronolide A 11,12-carbamate
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 1.2: 2 h / 0 - 20 °C / Inert atmosphere 2.1: methanol / 3 h / Inert atmosphere; Reflux 3.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 24 h / 20 °C View Scheme |
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81103-11-9
clarithromycin
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 10 steps 1.1: dmap / dichloromethane / 18 h / 20 °C / Inert atmosphere 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 72 h / 35 °C / Inert atmosphere 3.1: N,N-dimethyl-formamide / 48 h / 35 °C / Inert atmosphere 4.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 5.1: sodium azide / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere 6.1: hydrogenchloride / methanol; water / 20 h / 20 °C 7.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere 7.2: 2 h / -78 - 20 °C / Inert atmosphere 8.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 8.2: 2 h / 0 - 20 °C / Inert atmosphere 9.1: methanol / 3 h / Inert atmosphere; Reflux 10.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 24 h / 20 °C View Scheme | |
| Multi-step reaction with 10 steps 1.1: triethylamine / ethyl acetate / 24 h / 20 - 25 °C 2.1: hydrogenchloride / water; ethanol / 1.5 h 3.1: pyridine / dichloromethane / 1 h / -20 - 5 °C / Inert atmosphere 4.1: pyridinium chlorochromate / dichloromethane / 24 h / 20 °C 5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 24 h / 20 °C 6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -25 - -20 °C / Inert atmosphere 6.2: 1 h / -15 - -10 °C 7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 55 - 65 °C 8.1: potassium tert-butylate / tetrahydrofuran / 1 h / -30 - -20 °C / Inert atmosphere 8.2: 1.5 h / -25 - -20 °C 9.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / acetonitrile / 20 °C / Inert atmosphere 10.1: methanol / 16 h / 20 °C View Scheme | |
| Multi-step reaction with 12 steps 1.1: triethylamine / ethyl acetate / 24 h / 20 - 25 °C 2.1: hydrogenchloride / water; ethanol / 1.5 h 3.1: pyridine / dichloromethane / 1 h / -20 - 5 °C / Inert atmosphere 4.1: pyridinium chlorochromate / dichloromethane / 24 h / 20 °C 5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 24 h / 20 °C 6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -25 - -20 °C / Inert atmosphere 6.2: 1 h / -15 - -10 °C 7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 16 h / 55 - 60 °C 8.1: pyridine / 2 h / 0 - 10 °C 9.1: sodium azide / N,N-dimethyl-formamide / 8 h / 20 °C 10.1: potassium tert-butylate / tetrahydrofuran / 1 h / -30 - -20 °C / Inert atmosphere 10.2: 1.5 h / -25 - -20 °C 11.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / acetonitrile / 20 °C / Inert atmosphere 12.1: methanol / 16 h / 20 °C View Scheme | |
| Multi-step reaction with 7 steps 1.1: dmap; triethylamine / ethyl acetate / 16 h / 70 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 24.5 h / 28 °C 3.1: hydrogenchloride / acetone; water / 12 h / 40 °C 4.1: dimethylsulfide / dichloromethane / 4 h / -20 °C 4.2: 1.5 h / -20 - 25 °C 5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane; dimethyl sulfoxide / 24 h / 25 °C 6.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / -35 °C 6.2: 2 h / -35 - 25 °C 7.1: hydrogenchloride / water; methanol / 24 h / 40 °C View Scheme |
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: methanol / 3 h / Inert atmosphere; Reflux 2: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 24 h / 20 °C View Scheme |
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152235-55-7
2',4''-di-O-acetyl-6-O-methylerythromycin A
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 9 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 72 h / 35 °C / Inert atmosphere 2.1: N,N-dimethyl-formamide / 48 h / 35 °C / Inert atmosphere 3.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 4.1: sodium azide / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere 5.1: hydrogenchloride / methanol; water / 20 h / 20 °C 6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere 6.2: 2 h / -78 - 20 °C / Inert atmosphere 7.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 7.2: 2 h / 0 - 20 °C / Inert atmosphere 8.1: methanol / 3 h / Inert atmosphere; Reflux 9.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 24 h / 20 °C View Scheme |
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217977-00-9
10,11-anhydro-2',4''-di-O-acetyl-12-O-(imidazol-1-ylcarbonyl)-6-O-methylerythromycin A
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1.1: N,N-dimethyl-formamide / 48 h / 35 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: sodium azide / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere 4.1: hydrogenchloride / methanol; water / 20 h / 20 °C 5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere 5.2: 2 h / -78 - 20 °C / Inert atmosphere 6.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 6.2: 2 h / 0 - 20 °C / Inert atmosphere 7.1: methanol / 3 h / Inert atmosphere; Reflux 8.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 24 h / 20 °C View Scheme |
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849407-71-2
C47H80N2O16
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 2.1: sodium azide / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere 3.1: hydrogenchloride / methanol; water / 20 h / 20 °C 4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere 4.2: 2 h / -78 - 20 °C / Inert atmosphere 5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 5.2: 2 h / 0 - 20 °C / Inert atmosphere 6.1: methanol / 3 h / Inert atmosphere; Reflux 7.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 24 h / 20 °C View Scheme |
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125637-07-2
(R)-3-hydroxy-2-methylpent-1-ene
-
-
760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 10 steps 1.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C 2.1: sodium periodate; potassium osmate(VI) dihydrate; 2,6-dimethylpyridine / water; tetrahydrofuran / 3 h 3.1: lithium chloride / tetrahydrofuran / 1.1 h / -20 °C 4.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 5.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 7.1: 130 °C 8.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 8.2: 0.58 h / 23 °C 9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 10.1: 12 h / 23 °C / 0.1 Torr 10.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 10 steps 1.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C 2.1: sodium periodate; potassium osmate(VI) dihydrate; 2,6-dimethylpyridine / water; tetrahydrofuran / 3 h 3.1: lithium chloride / tetrahydrofuran / 1.1 h / -20 °C 4.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 5.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 7.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 8.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 8.2: 0.58 h / 23 °C 9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 10.1: 12 h / 23 °C / 0.1 Torr 10.2: 2 h / 45 °C View Scheme |
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135393-98-5
(R)-tert-butyldimethyl((2-methylpent-1-en-3-yl)oxy)silane
-
-
760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 9 steps 1.1: sodium periodate; potassium osmate(VI) dihydrate; 2,6-dimethylpyridine / water; tetrahydrofuran / 3 h 2.1: lithium chloride / tetrahydrofuran / 1.1 h / -20 °C 3.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 4.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 6.1: 130 °C 7.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 7.2: 0.58 h / 23 °C 8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 9.1: 12 h / 23 °C / 0.1 Torr 9.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 9 steps 1.1: sodium periodate; potassium osmate(VI) dihydrate; 2,6-dimethylpyridine / water; tetrahydrofuran / 3 h 2.1: lithium chloride / tetrahydrofuran / 1.1 h / -20 °C 3.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 4.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 6.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 7.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 7.2: 0.58 h / 23 °C 8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 9.1: 12 h / 23 °C / 0.1 Torr 9.2: 2 h / 45 °C View Scheme |
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220018-22-4
(R)-3-((tert-butyldimethylsilyl)oxy)pentan-2-one
-
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1.1: lithium chloride / tetrahydrofuran / 1.1 h / -20 °C 2.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 3.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 5.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 6.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 6.2: 0.58 h / 23 °C 7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 8.1: 12 h / 23 °C / 0.1 Torr 8.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 8 steps 1.1: lithium chloride / tetrahydrofuran / 1.1 h / -20 °C 2.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 3.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 5.1: 130 °C 6.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 6.2: 0.58 h / 23 °C 7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 8.1: 12 h / 23 °C / 0.1 Torr 8.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 8 steps 1: lithium (1S,2R)-1-phenyl-2-(pyrrolidin-1-yl)-1-propanolate 2: bis(cyclopentadienyl)titanium dichloride; cyclopentylmagnesium bromide 3: Dess-Martin periodane 4: tetrabutyl ammonium fluoride 5: chlorobenzene / 132 °C 6: potassium tert-butylate; N-fluorobis(benzenesulfon)imide 7: 1,8-diazabicyclo[5.4.0]undec-7-ene 8: Imidazole hydrochloride / 60 °C View Scheme |
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-
760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: methanol / 24 h / 23 °C 2.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 2.2: 1 h / -78 °C 3.1: sodium L-ascorbate; copper(II) sulfate / water; tert-butyl alcohol / 16 h View Scheme |
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849407-75-6
11-N-(4-azido-butyl)-6-O-methyl-5-O-desosaminyl-3-oxo-erythronolide A 11,12-carbamate
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-
760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 1.2: 1 h / -78 °C 2.1: sodium L-ascorbate; copper(II) sulfate / water; tert-butyl alcohol / 16 h View Scheme |
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-
760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 11 steps 1.1: magnesium bromide ethyl etherate / dichloromethane / 0.17 h / -78 - -10 °C 1.2: 12 h / -78 °C 2.1: silver trifluoromethanesulfonate / dichloromethane; toluene / 1 h / 0 °C / Molecular sieve 3.1: hydrogen fluoride / acetonitrile / 12 h / 20 °C 4.1: Dess-Martin periodane / dichloromethane; water / 0.5 h / 20 °C 5.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 6.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 8.1: 130 °C 9.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 9.2: 0.58 h / 23 °C 10.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 11.1: 12 h / 23 °C / 0.1 Torr 11.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 11 steps 1.1: magnesium bromide ethyl etherate / dichloromethane / 0.17 h / -78 - -10 °C 1.2: 12 h / -78 °C 2.1: silver trifluoromethanesulfonate / dichloromethane; toluene / 1 h / 0 °C / Molecular sieve 3.1: hydrogen fluoride / acetonitrile / 12 h / 20 °C 4.1: Dess-Martin periodane / dichloromethane; water / 0.5 h / 20 °C 5.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 6.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 8.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 9.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 9.2: 0.58 h / 23 °C 10.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 11.1: 12 h / 23 °C / 0.1 Torr 11.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 11 steps 1: zinc(II) chloride 2: silver trifluoromethanesulfonate 3: hydrogen fluoride / water 4: Dess-Martin periodane 5: bis(cyclopentadienyl)titanium dichloride; cyclopentylmagnesium bromide 6: Dess-Martin periodane 7: tetrabutyl ammonium fluoride 8: chlorobenzene / 132 °C 9: potassium tert-butylate; N-fluorobis(benzenesulfon)imide 10: 1,8-diazabicyclo[5.4.0]undec-7-ene 11: Imidazole hydrochloride / 60 °C View Scheme |
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-
760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 3.1: 130 °C 4.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 4.2: 0.58 h / 23 °C 5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 6.1: 12 h / 23 °C / 0.1 Torr 6.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 6 steps 1.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 3.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 4.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 4.2: 0.58 h / 23 °C 5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 6.1: 12 h / 23 °C / 0.1 Torr 6.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 6 steps 1: Dess-Martin periodane 2: tetrabutyl ammonium fluoride 3: chlorobenzene / 132 °C 4: potassium tert-butylate; N-fluorobis(benzenesulfon)imide 5: 1,8-diazabicyclo[5.4.0]undec-7-ene 6: Imidazole hydrochloride / 60 °C View Scheme |
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-
760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 2.1: 130 °C 3.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 3.2: 0.58 h / 23 °C 4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 5.1: 12 h / 23 °C / 0.1 Torr 5.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 5 steps 1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 2.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 3.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 3.2: 0.58 h / 23 °C 4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 5.1: 12 h / 23 °C / 0.1 Torr 5.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 5 steps 1: tetrabutyl ammonium fluoride 2: chlorobenzene / 132 °C 3: potassium tert-butylate; N-fluorobis(benzenesulfon)imide 4: 1,8-diazabicyclo[5.4.0]undec-7-ene 5: Imidazole hydrochloride / 60 °C View Scheme |
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 2.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 2.2: 0.58 h / 23 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 4.1: 12 h / 23 °C / 0.1 Torr 4.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 4 steps 1.1: 130 °C 2.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 2.2: 0.58 h / 23 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 4.1: 12 h / 23 °C / 0.1 Torr 4.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 4 steps 1: chlorobenzene / 132 °C 2: potassium tert-butylate; N-fluorobis(benzenesulfon)imide 3: 1,8-diazabicyclo[5.4.0]undec-7-ene 4: Imidazole hydrochloride / 60 °C View Scheme |
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-
760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 1.2: 0.58 h / 23 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 3.1: 12 h / 23 °C / 0.1 Torr 3.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 3 steps 1: potassium tert-butylate; N-fluorobis(benzenesulfon)imide 2: 1,8-diazabicyclo[5.4.0]undec-7-ene 3: Imidazole hydrochloride / 60 °C View Scheme |
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-
760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 10 steps 1.1: silver trifluoromethanesulfonate / dichloromethane; toluene / 1 h / 0 °C / Molecular sieve 2.1: hydrogen fluoride / acetonitrile / 12 h / 20 °C 3.1: Dess-Martin periodane / dichloromethane; water / 0.5 h / 20 °C 4.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 5.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 7.1: 130 °C 8.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 8.2: 0.58 h / 23 °C 9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 10.1: 12 h / 23 °C / 0.1 Torr 10.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 10 steps 1.1: silver trifluoromethanesulfonate / dichloromethane; toluene / 1 h / 0 °C / Molecular sieve 2.1: hydrogen fluoride / acetonitrile / 12 h / 20 °C 3.1: Dess-Martin periodane / dichloromethane; water / 0.5 h / 20 °C 4.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 5.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 7.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 8.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 8.2: 0.58 h / 23 °C 9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 10.1: 12 h / 23 °C / 0.1 Torr 10.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 10 steps 1: silver trifluoromethanesulfonate 2: hydrogen fluoride / water 3: Dess-Martin periodane 4: bis(cyclopentadienyl)titanium dichloride; cyclopentylmagnesium bromide 5: Dess-Martin periodane 6: tetrabutyl ammonium fluoride 7: chlorobenzene / 132 °C 8: potassium tert-butylate; N-fluorobis(benzenesulfon)imide 9: 1,8-diazabicyclo[5.4.0]undec-7-ene 10: Imidazole hydrochloride / 60 °C View Scheme |
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-
760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 2.1: 12 h / 23 °C / 0.1 Torr 2.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 2 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene 2: Imidazole hydrochloride / 60 °C View Scheme |
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: tetrabutyl ammonium fluoride / 130 °C 2.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 2.2: 0.58 h / 23 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 4.1: 12 h / 23 °C / 0.1 Torr 4.2: 2 h / 45 °C View Scheme |
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 9 steps 1.1: hydrogen fluoride / acetonitrile / 12 h / 20 °C 2.1: Dess-Martin periodane / dichloromethane; water / 0.5 h / 20 °C 3.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 4.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 6.1: 130 °C 7.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 7.2: 0.58 h / 23 °C 8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 9.1: 12 h / 23 °C / 0.1 Torr 9.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 9 steps 1.1: hydrogen fluoride / acetonitrile / 12 h / 20 °C 2.1: Dess-Martin periodane / dichloromethane; water / 0.5 h / 20 °C 3.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 4.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 6.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 7.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 7.2: 0.58 h / 23 °C 8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 9.1: 12 h / 23 °C / 0.1 Torr 9.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 9 steps 1: hydrogen fluoride / water 2: Dess-Martin periodane 3: bis(cyclopentadienyl)titanium dichloride; cyclopentylmagnesium bromide 4: Dess-Martin periodane 5: tetrabutyl ammonium fluoride 6: chlorobenzene / 132 °C 7: potassium tert-butylate; N-fluorobis(benzenesulfon)imide 8: 1,8-diazabicyclo[5.4.0]undec-7-ene 9: Imidazole hydrochloride / 60 °C View Scheme |
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1.1: Dess-Martin periodane / dichloromethane; water / 0.5 h / 20 °C 2.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 3.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 5.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 6.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 6.2: 0.58 h / 23 °C 7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 8.1: 12 h / 23 °C / 0.1 Torr 8.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 8 steps 1.1: Dess-Martin periodane / dichloromethane; water / 0.5 h / 20 °C 2.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 3.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 5.1: 130 °C 6.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 6.2: 0.58 h / 23 °C 7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 8.1: 12 h / 23 °C / 0.1 Torr 8.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 8 steps 1: Dess-Martin periodane 2: bis(cyclopentadienyl)titanium dichloride; cyclopentylmagnesium bromide 3: Dess-Martin periodane 4: tetrabutyl ammonium fluoride 5: chlorobenzene / 132 °C 6: potassium tert-butylate; N-fluorobis(benzenesulfon)imide 7: 1,8-diazabicyclo[5.4.0]undec-7-ene 8: Imidazole hydrochloride / 60 °C View Scheme |
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-
760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 2.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 4.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 5.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 5.2: 0.58 h / 23 °C 6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 7.1: 12 h / 23 °C / 0.1 Torr 7.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 7 steps 1.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 2.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 4.1: 130 °C 5.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 5.2: 0.58 h / 23 °C 6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 7.1: 12 h / 23 °C / 0.1 Torr 7.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 7 steps 1: bis(cyclopentadienyl)titanium dichloride; cyclopentylmagnesium bromide 2: Dess-Martin periodane 3: tetrabutyl ammonium fluoride 4: chlorobenzene / 132 °C 5: potassium tert-butylate; N-fluorobis(benzenesulfon)imide 6: 1,8-diazabicyclo[5.4.0]undec-7-ene 7: Imidazole hydrochloride / 60 °C View Scheme |
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-
26735-86-4
tert-butyl 2-methyl-3-oxopentanoate
-
-
760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 13 steps 1.1: acetic anhydride; sulfuric acid / 5 h / 0 - 20 °C 2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -78 - 0 °C 2.2: 3 h / -78 - 20 °C 3.1: magnesium bromide ethyl etherate / dichloromethane / 0.17 h / -78 - -10 °C 3.2: 12 h / -78 °C 4.1: silver trifluoromethanesulfonate / dichloromethane; toluene / 1 h / 0 °C / Molecular sieve 5.1: hydrogen fluoride / acetonitrile / 12 h / 20 °C 6.1: Dess-Martin periodane / dichloromethane; water / 0.5 h / 20 °C 7.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 8.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 10.1: 130 °C 11.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 11.2: 0.58 h / 23 °C 12.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 13.1: 12 h / 23 °C / 0.1 Torr 13.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 13 steps 1.1: acetic anhydride; sulfuric acid / 5 h / 0 - 20 °C 2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -78 - 0 °C 2.2: 3 h / -78 - 20 °C 3.1: magnesium bromide ethyl etherate / dichloromethane / 0.17 h / -78 - -10 °C 3.2: 12 h / -78 °C 4.1: silver trifluoromethanesulfonate / dichloromethane; toluene / 1 h / 0 °C / Molecular sieve 5.1: hydrogen fluoride / acetonitrile / 12 h / 20 °C 6.1: Dess-Martin periodane / dichloromethane; water / 0.5 h / 20 °C 7.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 8.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 10.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 11.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 11.2: 0.58 h / 23 °C 12.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 13.1: 12 h / 23 °C / 0.1 Torr 13.2: 2 h / 45 °C View Scheme |
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 13 steps 1.1: potassium hydride / diethyl ether; mineral oil / 1 h / 0 °C 1.2: 2 h / 20 °C 2.1: periodic acid / ethyl acetate 3.1: magnesium bromide ethyl etherate / dichloromethane / 0.17 h / -78 - -10 °C 3.2: 12 h / -78 °C 4.1: silver trifluoromethanesulfonate / dichloromethane; toluene / 1 h / 0 °C / Molecular sieve 5.1: hydrogen fluoride / acetonitrile / 12 h / 20 °C 6.1: Dess-Martin periodane / dichloromethane; water / 0.5 h / 20 °C 7.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 8.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 10.1: 130 °C 11.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 11.2: 0.58 h / 23 °C 12.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 13.1: 12 h / 23 °C / 0.1 Torr 13.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 13 steps 1.1: potassium hydride / diethyl ether; mineral oil / 1 h / 0 °C 1.2: 2 h / 20 °C 2.1: periodic acid / ethyl acetate 3.1: magnesium bromide ethyl etherate / dichloromethane / 0.17 h / -78 - -10 °C 3.2: 12 h / -78 °C 4.1: silver trifluoromethanesulfonate / dichloromethane; toluene / 1 h / 0 °C / Molecular sieve 5.1: hydrogen fluoride / acetonitrile / 12 h / 20 °C 6.1: Dess-Martin periodane / dichloromethane; water / 0.5 h / 20 °C 7.1: bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride 8.1: Dess-Martin periodane / dichloromethane; water / 0.08 h / 22 °C 9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 23 °C 10.1: chlorobenzene / 19.17 h / 23 - 150 °C / Inert atmosphere; Sonication 11.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C 11.2: 0.58 h / 23 °C 12.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.5 h / -10 °C 13.1: 12 h / 23 °C / 0.1 Torr 13.2: 2 h / 45 °C View Scheme | |
| Multi-step reaction with 13 steps 1: potassium hydride 2: periodic acid 3: zinc(II) chloride 4: silver trifluoromethanesulfonate 5: hydrogen fluoride / water 6: Dess-Martin periodane 7: bis(cyclopentadienyl)titanium dichloride; cyclopentylmagnesium bromide 8: Dess-Martin periodane 9: tetrabutyl ammonium fluoride 10: chlorobenzene / 132 °C 11: potassium tert-butylate; N-fluorobis(benzenesulfon)imide 12: 1,8-diazabicyclo[5.4.0]undec-7-ene 13: Imidazole hydrochloride / 60 °C View Scheme |
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
| Conditions | Yield |
|---|---|
| With di-isopropyl azodicarboxylate In dichloromethane at 20℃; for 24h; | 20% |
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
-
-
76-05-1
trifluoroacetic acid
| Conditions | Yield |
|---|---|
| Stage #1: (3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone; C103H122N10O20S With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere; Stage #2: trifluoroacetic acid In water; acetonitrile | A 16% B 12% |
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760981-83-7
(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
-
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76-05-1
trifluoroacetic acid
| Conditions | Yield |
|---|---|
| Stage #1: (3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone; C103H122N10O20S With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere; Stage #2: trifluoroacetic acid In water-d2; acetonitrile | A 12% B 13% |
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