in stock Package:1kg,10kg Application:Pharmaceutical intermediates
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
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inquiry6-Benzofurancarboxylic acid CAS No.:77095-51-3 Name: 6-Benzofurancarboxylic acid Molecular Structure Molecular Formula: C9H6O3
Cas:77095-51-3
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
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inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquirybenzofuran-6-carboxylic acid Basic information Product Name: benzofuran-6-carboxylic acid Synonyms: benzofuran-6-carboxylic acid;6-Benzofurancarboxylic acid;1-benzo
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
Cas:77095-51-3
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inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:77095-51-3
Min.Order:100 Kilogram
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inquirybenzofuran-6-carboxylic acid CAS:77095-51-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality org
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryOur Advantage: high quality with competitive price
Cas:77095-51-3
Min.Order:1 Kilogram
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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Min.Order:100 Gram
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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Min.Order:1 Gram
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:77095-51-3
Min.Order:4 Kilogram
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inquiry1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product
Cas:77095-51-3
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:77095-51-3
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inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:77095-51-3
Min.Order:1 Gram
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:77095-51-3
Min.Order:10 Gram
FOB Price: $100.0
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inquiryMulti-target purpose intermediate with wide usage Commercial production from grams to tons, with technical documents package support, and audit and inspection support. With high purity and optimized and stable process. Appearance:white s
Cas:77095-51-3
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryProduct name: 6-Benzofurancarboxylic Acid CAS No.:77095-51-3 Molecule Formula:C9H6O3 Molecule Weight:162.14 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard TESTING
Cas:77095-51-3
Min.Order:1 Kilogram
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:77095-51-3
Min.Order:1 Gram
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:77095-51-3
Min.Order:1 Milligram
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inquiryProduct Name: benzofuran-6-carboxylic acid Synonyms: Lifitegrast Intermediate 1;Benzofuran-6-Caboxylic Acid;benzofuran-6-carboxylic acid;6-Benzofurancarboxylic acid;1-benzofuran-6-carboxylic acid;Lifitegrast Impurity 29 CAS: 77095-51-3 MF:
Cas:77095-51-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:77095-51-3
Min.Order:1 Kilogram
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Type:Trading Company
inquirymethyl benzofuran-6-carboxylate
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
With lithium hydroxide; water In tetrahydrofuran at 20℃; for 1h; | 100% |
Stage #1: methyl benzofuran-6-carboxylate With lithium hydroxide In methanol; water at 20℃; Stage #2: With hydrogenchloride In water | 97% |
With water; lithium hydroxide In methanol | 97% |
ethyl benzofuran-6-carboxylate
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; methanol | 97% |
methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate
methanol
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate With copper(l) iodide; triethylamine In ethanol at 75℃; for 3h; Stage #2: methanol With pyrographite In ethanol for 1h; Heating / reflux; Stage #3: With sodium hydroxide In ethanol at 20℃; | 93% |
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
With copper(l) iodide; triethylamine In ethanol at 75 - 85℃; for 3h; | 92% |
benzo[b]furan-6-carbonitrile
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
With water; sodium hydroxide at 90℃; | 85% |
benzofuran-6-carboxaldehyde
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
With dihydrogen peroxide; sodium hydroxide In water at 75 - 90℃; | 70% |
Conditions | Yield |
---|---|
Stage #1: 6-bromo-benzofuran With magnesium; ethylene dibromide In tetrahydrofuran at 70℃; for 2h; Stage #2: carbon dioxide In tetrahydrofuran at -40℃; | 24% |
methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: CuI; Et3N / ethanol / 3 h / 75 °C 1.2: DARCO / ethanol; methanol / 1 h / Heating 2.1: aq. NaOH / 20 °C View Scheme |
methyl 3-hydroxy-4-iodobenzoate
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 91 percent / Pd(PPh3)2Cl2; CuI; Et3N / tetrahydrofuran; CHCl3 / 4 h / 50 °C 2.1: CuI; Et3N / ethanol / 3 h / 75 °C 2.2: DARCO / ethanol; methanol / 1 h / Heating 3.1: aq. NaOH / 20 °C View Scheme |
3-hydroxy-4-(2-propenyl)benzoic acid
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: SOCl2, DMF / 3 h 2: 0.5 h 3: 1.) O3, 2.) (CH3)2S / 1.) MeOH, -70 deg C, 15 min, 2.) MeOH, RT, overnight 4: 85percent H3PO4 / 100 °C 5: 87 percent / 35percent aq. KOH / methanol / 100 °C View Scheme |
methyl 3-(prop-2-enyloxy)benzoate
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 27 percent / 1 h / 230 °C 2: SOCl2, DMF / 3 h 3: 0.5 h 4: 1.) O3, 2.) (CH3)2S / 1.) MeOH, -70 deg C, 15 min, 2.) MeOH, RT, overnight 5: 85percent H3PO4 / 100 °C 6: 87 percent / 35percent aq. KOH / methanol / 100 °C View Scheme |
methyl 3-hydroxy-4-(2-propenyl)benzoate
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) O3, 2.) (CH3)2S / 1.) MeOH, -70 deg C, 15 min, 2.) MeOH, RT, overnight 2: 85percent H3PO4 / 100 °C 3: 87 percent / 35percent aq. KOH / methanol / 100 °C View Scheme |
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 0.5 h 2: 1.) O3, 2.) (CH3)2S / 1.) MeOH, -70 deg C, 15 min, 2.) MeOH, RT, overnight 3: 85percent H3PO4 / 100 °C 4: 87 percent / 35percent aq. KOH / methanol / 100 °C View Scheme |
methyl 2-hydroxy-2,3-dihydrobenzofuran-6-carboxylate
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85percent H3PO4 / 100 °C 2: 87 percent / 35percent aq. KOH / methanol / 100 °C View Scheme |
methyl 4-formyl-3-hydroxybenzoate
benzofuran-6-carboxylic acid
methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate
A
benzofuran-6-carboxylic acid
B
N-[(1S,2R,4R)-7-Azabicyclo[2.2.1]hept-2-yl]-1-benzofuran-6-carboxamide hydrochloride
Conditions | Yield |
---|---|
With sodium hydroxide; copper(I) iodide In methanol; ethanol; water; triethylamine | A n/a B 1.83 g (93%) |
6-hydroxybenzofuran
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dichloromethane / 72 h / 20 °C 2: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr 3: lithium hydroxide / methanol; water / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: dichloromethane / 72 h 2: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr / Autoclave 3: lithium hydroxide; water / methanol View Scheme |
6-hydroxybenzofuran-3-one
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / acetone / 20 °C 2.1: sodium tetrahydroborate / methanol / 20 °C 2.2: 2 h / 20 °C 2.3: 20 °C / Darkness; Inert atmosphere 3.1: dichloromethane / 72 h / 20 °C 4.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr 5.1: lithium hydroxide / methanol; water / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1: triethylamine / acetone 2: sodium tetrahydroborate / methanol / 20 °C 3: hydrogenchloride; water / tetrahydrofuran / 28 °C / Inert atmosphere; Darkness 4: dichloromethane / 72 h 5: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr / Autoclave 6: lithium hydroxide; water / methanol View Scheme |
trifluoromethanesulfonic acid benzofuran-6-yl ester
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr 2: lithium hydroxide / methanol; water / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr / Autoclave 2: lithium hydroxide; water / methanol View Scheme |
6-(tert-butyl-dimethylsilanyloxy)-[2H]-benzofuran-3-one
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / methanol / 20 °C 1.2: 2 h / 20 °C 1.3: 20 °C / Darkness; Inert atmosphere 2.1: dichloromethane / 72 h / 20 °C 3.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr 4.1: lithium hydroxide / methanol; water / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: sodium tetrahydroborate / methanol / 20 °C 2: hydrogenchloride; water / tetrahydrofuran / 28 °C / Inert atmosphere; Darkness 3: dichloromethane / 72 h 4: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr / Autoclave 5: lithium hydroxide; water / methanol View Scheme |
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogenchloride; water / tetrahydrofuran / 28 °C / Inert atmosphere; Darkness 2: dichloromethane / 72 h 3: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr / Autoclave 4: lithium hydroxide; water / methanol View Scheme |
6-bromo-benzofuran
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: isopropylmagnesium bromide / tetrahydrofuran / 0.5 h / -25 °C 1.2: -25 °C 2.1: sodium hydroxide; dihydrogen peroxide / water / 75 - 90 °C View Scheme | |
Multi-step reaction with 2 steps 1: tetrahydrofuran / Reflux 2: sodium hydroxide; water / 90 °C View Scheme |
3-Carboxyphenol
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: methanesulfonic acid / 3 h / 80 °C / Large scale 2: thionyl chloride / 3 h / 60 °C / Large scale 3: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere; Large scale 4: sodium hydroxide / methanol; water / 1 h / 20 - 35 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide; sodium hypochlorite / methanol / 72 h / 0 - 30 °C 2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran; chloroform / 4 h / 50 - 60 °C / Inert atmosphere 3: copper(l) iodide; triethylamine / ethanol / 3 h / 75 - 85 °C View Scheme |
4-formyl-3-hydroxybenzoic acid
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: thionyl chloride / 3 h / 60 °C / Large scale 2: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere; Large scale 3: sodium hydroxide / methanol; water / 1 h / 20 - 35 °C / Large scale View Scheme |
3-hydroxy-4-iodobenzoic acid
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran; chloroform / 4 h / 50 - 60 °C / Inert atmosphere 2: copper(l) iodide; triethylamine / ethanol / 3 h / 75 - 85 °C View Scheme |
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
With thionyl chloride; N,N-dimethyl-formamide In toluene Inert atmosphere; Heating; | 100% |
With thionyl chloride In benzene for 3h; Heating; | |
With methanesulfonyl chloride; triethylamine |
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: benzofuran-6-carboxylic acid With N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 20 - 30℃; for 2h; Inert atmosphere; Stage #2: C10H9Cl2NO2*C2HF3O2 In tetrahydrofuran at 20 - 30℃; | 98% |
methanol
benzofuran-6-carboxylic acid
methyl benzofuran-6-carboxylate
Conditions | Yield |
---|---|
With sulfuric acid at 20℃; | 96% |
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: benzofuran-6-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: (S)-2-(8-chloro-2,3-dihydro-1H-pyrrole[3,2,1-ij]isoquinazolin-7-carbonylamino)-3-(3-(methanesulfonyl)phenyl)propanoic acid benzyl ester trifluoroacetate salt In N,N-dimethyl-formamide at 20℃; for 12h; | 95% |
benzofuran-6-carboxylic acid
dichloro quinoline ester
C20H15Cl2NO4
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dmap In DMF (N,N-dimethyl-formamide) at 20℃; for 15h; | 92% |
Stage #1: benzofuran-6-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In tetrahydrofuran at 25 - 35℃; for 0.5h; Stage #2: dichloro quinoline ester In tetrahydrofuran at 25 - 35℃; for 3h; |
benzofuran-6-carboxylic acid
4-(4-methoxybenzyl)-6-piperidin-4-ylpyrimidin-2-amine
4-[1-(1-benzofuran-6-ylcarbonyl)piperidin-4-yl]-6-(4-methoxybenzyl)pyrimidin-2-amine
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform at 20℃; | 88% |
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: benzofuran-6-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; for 3h; Inert atmosphere; Stage #2: 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid In dichloromethane at 30℃; for 8h; Reagent/catalyst; Temperature; Solvent; | 87.01% |
benzofuran-6-carboxylic acid
(S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -10 - 20℃; Reagent/catalyst; Solvent; Temperature; | 83.8% |
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 10 - 20℃; for 1.5h; |
Conditions | Yield |
---|---|
Stage #1: benzofuran-6-carboxylic acid; (S)-2-(5-(7-dichloro-1,2,3,4-tetrahydroisoquinolin-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid) hydrochloride In dichloromethane; dimethyl sulfoxide at 0 - 5℃; for 2h; Stage #2: N-cyclohexyl-cyclohexanamine In water at 0 - 25℃; for 41h; pH=8.3; Temperature; | 65% |
benzofuran-6-carboxylic acid
6a-naltrexamine hydrochloride
Conditions | Yield |
---|---|
Stage #1: benzofuran-6-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide for 1h; Molecular sieve; Cooling with ice; Inert atmosphere; Stage #2: 6a-naltrexamine hydrochloride In N,N-dimethyl-formamide at 20℃; Inert atmosphere; Stage #3: With potassium carbonate In methanol at 20℃; Inert atmosphere; | 62% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 23℃; for 12h; Inert atmosphere; | 54% |
Conditions | Yield |
---|---|
Stage #1: benzofuran-6-carboxylic acid With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) at 20℃; for 0.5h; Stage #2: C19H19Cl2N3O4S In DMF (N,N-dimethyl-formamide) at 45℃; for 12h; | 50% |
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 45℃; |
benzofuran-6-carboxylic acid
6β-naltrexamine
Conditions | Yield |
---|---|
Stage #1: benzofuran-6-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide for 1h; Molecular sieve; Cooling with ice; Inert atmosphere; Stage #2: 6β-naltrexamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere; Stage #3: With potassium carbonate In methanol at 20℃; Inert atmosphere; | 44% |
benzofuran-6-carboxylic acid
(3R)-quinuclidin-3-amine dihydrochloride
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 18h; | |
With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) at 0℃; for 18h; |
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: thionyl chloride / benzene / 3 h / Heating 2: CH2Cl2 / 3 h / Ambient temperature 3: thionyl chloride / 12 h / Ambient temperature View Scheme |
benzofuran-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: thionyl chloride / benzene / 3 h / Heating 2: CH2Cl2 / 3 h / Ambient temperature View Scheme |
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