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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Service: 1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment. 2. Quality can be promised. Hot sell to Worldwide. 3. Payment Terms: T/T,Western union, t/t 4. Free Sample available at any time. 5. Tracking your order at a

1-BENZOFURAN-6-CARBALDEHYDE CAS 123297-88-1

Cas:123297-88-1

Min.Order:1 Kilogram

FOB Price: $150.0 / 200.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

6-Benzofurancarboxaldehyde 123297-88-1

Cas:123297-88-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

1-BENZOFURAN-6-CARBALDEHYDE CAS:123297-88-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga

1-BENZOFURAN-6-CARBALDEHYDE CAS:123297-88-1

Cas:123297-88-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

6-Benzofurancarboxaldehyde

Cas:123297-88-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

6-Benzofurancarboxaldehyde

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

6-Benzofurancarboxaldehyde

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

6-Benzofurancarboxaldehyde

Cas:123297-88-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

6-Benzofurancarboxaldehyde

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Other

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

6-Benzofurancarboxaldehyde

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Manufacturers

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Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

1-BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

6-Benzofurancarboxaldehyde

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

1-BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world.2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.3,our staff consists of highly qualified in

1-BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

6-Benzofurancarboxaldehyde

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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DB BIOTECH CO., LTD

best seller Application:API

1-BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou Fandachem Co.,Ltd

1-BENZOFURAN-6-CARBALDEHYDEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

1-BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Other

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1-BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Send Pharmaceutical Technology Co., Ltd.

stock,low price,high quality,high purity,good sevice Application:R&D

benzofuran-6-carbaldehyde

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

1-BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Other

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Shanghai Terui OP New Material Technology Co., Ltd.

The factory supplies Application:manufacturing supplies

6-Benzofurancarboxaldehyde

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Trading Company

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Hebei Muhuang Technology Co., Ltd

best seller Application:API

1-BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1-BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

1-BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

1-BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

BENZOFURAN-6-CARBALDEHYDE CAS NO.123297-88-1

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Toda Biotechnology Co., Limited.

Todachem specialize in exporting chemicals for 10 years, we manufacture and distribute high quality pharmaceutical APIs, intermediates, special chemicals, active molecule and other fine chemicals. We have our research laboratory and more than 100 n

Factory direct supply 1-BENZOFURAN-6-CARBALDEHYDE with best quality

Cas:123297-88-1

Min.Order:1 Kilogram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Shandong Jucheng Import & Export Co. , Ltd.

Shandong Jucheng chemical is a leading chemical manufacturer and supplier in China. We develop, manufacture and market high quality pharmaceuticals, intermediates, specialty chemicals and OLED intermediates and other fine chemicals. Shandong Jucheng

6-Benzofurancarboxaldehyde

Cas:123297-88-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Trading Company

inquiry

AOPHARM

Aopharm is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in modes of

1-BENZOFURAN-6-CARBALDEHYDE

Cas:123297-88-1

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

6-Benzofurancarboxaldehyde

Cas:123297-88-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

6-bromo-benzofuran
128851-73-0

6-bromo-benzofuran

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

Conditions
ConditionsYield
Stage #1: 6-bromo-benzofuran With isopropylmagnesium bromide In tetrahydrofuran at -25℃; for 0.5h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -25℃;
80%
Stage #1: 6-bromo-benzofuran With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 0.0833333h; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In diethyl ether; pentane at -78 - 0℃; for 0.5h; Inert atmosphere;
54%
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2-(3-bromophenoxy)acetaldehyde diethyl acetal
204452-94-8

2-(3-bromophenoxy)acetaldehyde diethyl acetal

A

benzofuran-7-carboxaldehyde
95333-14-5

benzofuran-7-carboxaldehyde

B

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

Conditions
ConditionsYield
Stage #1: 2-(3-bromophenoxy)acetaldehyde diethyl acetal In toluene for 3h; Reflux;
Stage #2: N,N-dimethyl-formamide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h;
A n/a
B 34%
carbon monoxide
201230-82-2

carbon monoxide

trifluoromethanesulfonic acid benzofuran-6-yl ester
227752-25-2

trifluoromethanesulfonic acid benzofuran-6-yl ester

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

Conditions
ConditionsYield
With palladium diacetate; triethylamine; diphenylphosphinopropane; tri-n-octylsilane In N,N-dimethyl-formamide at 70℃; for 2h;29%
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2-(3-bromophenoxy)acetaldehyde diethyl acetal
204452-94-8

2-(3-bromophenoxy)acetaldehyde diethyl acetal

A

benzofuran-4-carboxaldehyde
95333-13-4

benzofuran-4-carboxaldehyde

B

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

Conditions
ConditionsYield
With PPA; tert.-butyl lithium 1.) benzene, reflux, 2.) Et2O, -78 deg C, 3.) Et2O; Multistep reaction;
6-hydroxybenzofuran
13196-11-7

6-hydroxybenzofuran

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 96 percent / triethylamine / CH2Cl2 / 1.5 h / 0 - 20 °C
2: 29 percent / Pd(OAc)2; diphenylphosphinopropane; triethylamine / trioctylsilane / dimethylformamide / 2 h / 70 °C
View Scheme
6-hydroxybenzofuran-3-one
6272-26-0

6-hydroxybenzofuran-3-one

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / dimethylformamide / 2 h / 20 °C
2: NaBH4 / methanol / 1 h / 20 °C
3: 6.93 g / aq. HCl / dioxane / 24 h / 20 °C
4: 96 percent / triethylamine / CH2Cl2 / 1.5 h / 0 - 20 °C
5: 29 percent / Pd(OAc)2; diphenylphosphinopropane; triethylamine / trioctylsilane / dimethylformamide / 2 h / 70 °C
View Scheme
6-(tert-butyl-dimethylsilanyloxy)-[2H]-benzofuran-3-one
299912-77-9

6-(tert-butyl-dimethylsilanyloxy)-[2H]-benzofuran-3-one

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaBH4 / methanol / 1 h / 20 °C
2: 6.93 g / aq. HCl / dioxane / 24 h / 20 °C
3: 96 percent / triethylamine / CH2Cl2 / 1.5 h / 0 - 20 °C
4: 29 percent / Pd(OAc)2; diphenylphosphinopropane; triethylamine / trioctylsilane / dimethylformamide / 2 h / 70 °C
View Scheme
3-hydroxy-6-silyloxy-[2,3]dihydrobenzofuran
1056942-29-0

3-hydroxy-6-silyloxy-[2,3]dihydrobenzofuran

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 6.93 g / aq. HCl / dioxane / 24 h / 20 °C
2: 96 percent / triethylamine / CH2Cl2 / 1.5 h / 0 - 20 °C
3: 29 percent / Pd(OAc)2; diphenylphosphinopropane; triethylamine / trioctylsilane / dimethylformamide / 2 h / 70 °C
View Scheme
3-Bromophenol
591-20-8

3-Bromophenol

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF
2: 1.) polyphosphoric acid, 2.) t-BuLi / 1.) benzene, reflux, 2.) Et2O, -78 deg C, 3.) Et2O
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / dimethyl sulfoxide / 12 h / 20 - 160 °C / Inert atmosphere
2.1: polyphosphoric acid (PPA) / toluene / 4 h / 20 °C / Inert atmosphere; Reflux
3.1: tert.-butyl lithium / diethyl ether; pentane / 0.08 h / -78 °C / Inert atmosphere
3.2: 0.5 h / -78 - 0 °C / Inert atmosphere
View Scheme
2-(3-bromophenoxy)acetaldehyde diethyl acetal
204452-94-8

2-(3-bromophenoxy)acetaldehyde diethyl acetal

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: polyphosphoric acid (PPA) / toluene / 4 h / 20 °C / Inert atmosphere; Reflux
2.1: tert.-butyl lithium / diethyl ether; pentane / 0.08 h / -78 °C / Inert atmosphere
2.2: 0.5 h / -78 - 0 °C / Inert atmosphere
View Scheme
3-Bromophenol
591-20-8

3-Bromophenol

A

benzofuran-7-carboxaldehyde
95333-14-5

benzofuran-7-carboxaldehyde

B

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C
2.1: polyphosphoric acid / toluene / 3 h / Reflux
2.2: 2 h / -78 °C
View Scheme
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
With dihydrogen peroxide; sodium hydroxide In water at 75 - 90℃;70%
1-bromo-2-(triisopropylsilyl)acetylene
111409-79-1

1-bromo-2-(triisopropylsilyl)acetylene

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

5-((triisopropylsilyl)ethynyl)benzofuran-6-carbaldehyde

5-((triisopropylsilyl)ethynyl)benzofuran-6-carbaldehyde

Conditions
ConditionsYield
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; lithium acetate; 3,5-Bis-(trifluoromethyl)aniline; silver carbonate; trifluoroacetic acid In 1,2-dichloro-ethane at 70℃; Inert atmosphere; Sealed tube;53%
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

benzofuran-6-carbaldehyde oxime

benzofuran-6-carbaldehyde oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; potassium carbonate In ethanol; water at 20℃;41%
Methyl azidoacetate
1816-92-8

Methyl azidoacetate

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

(Z)-methyl 2-azido-3-(benzofuran-6-yl)acrylate
1279721-92-4

(Z)-methyl 2-azido-3-(benzofuran-6-yl)acrylate

Conditions
ConditionsYield
With sodium methylate In methanol at -20 - -10℃; Inert atmosphere;38%
nitromethane
75-52-5

nitromethane

benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

6-((E)-2-Nitro-vinyl)-benzofuran

6-((E)-2-Nitro-vinyl)-benzofuran

Conditions
ConditionsYield
With sodium hydroxide at 15℃;
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

4-Benzofuran-6-yl-2-(4-methoxy-phenyl)-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester
1026183-98-1

4-Benzofuran-6-yl-2-(4-methoxy-phenyl)-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 50percent aq. NaOH / 15 °C
2: DBU / propan-2-ol; tetrahydrofuran
3: H2 / W-2 Raney Ni / ethyl acetate / 3040 Torr
View Scheme
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

3-Benzofuran-6-yl-2-(4-methoxy-benzoyl)-4-nitro-butyric acid ethyl ester
1025833-28-6

3-Benzofuran-6-yl-2-(4-methoxy-benzoyl)-4-nitro-butyric acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 50percent aq. NaOH / 15 °C
2: DBU / propan-2-ol; tetrahydrofuran
View Scheme
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

(2S,3S,4S)-4-Benzofuran-6-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

(2S,3S,4S)-4-Benzofuran-6-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 50percent aq. NaOH / 15 °C
2: DBU / propan-2-ol; tetrahydrofuran
3: H2 / W-2 Raney Ni / ethyl acetate / 3040 Torr
4: NaBH3CN, HCl / ethanol; tetrahydrofuran
View Scheme
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

(2R,3S,4S)-4-Benzofuran-6-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

(2R,3S,4S)-4-Benzofuran-6-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 50percent aq. NaOH / 15 °C
2: DBU / propan-2-ol; tetrahydrofuran
3: H2 / W-2 Raney Ni / ethyl acetate / 3040 Torr
4: NaBH3CN, HCl / ethanol; tetrahydrofuran
View Scheme
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

(2S,3S,4R)-4-Benzofuran-6-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

(2S,3S,4R)-4-Benzofuran-6-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 50percent aq. NaOH / 15 °C
2: DBU / propan-2-ol; tetrahydrofuran
3: H2 / W-2 Raney Ni / ethyl acetate / 3040 Torr
4: NaBH3CN, HCl / ethanol; tetrahydrofuran
View Scheme
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

(2R,3S,4R)-4-Benzofuran-6-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

(2R,3S,4R)-4-Benzofuran-6-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 50percent aq. NaOH / 15 °C
2: DBU / propan-2-ol; tetrahydrofuran
3: H2 / W-2 Raney Ni / ethyl acetate / 3040 Torr
4: NaBH3CN, HCl / ethanol; tetrahydrofuran
View Scheme
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

methyl 5H-furo[2,3-f]indole-6-carboxylate
1279721-95-7

methyl 5H-furo[2,3-f]indole-6-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium methylate / methanol / -20 - -10 °C / Inert atmosphere
2: iron(II) triflate / tetrahydrofuran / 24 h / 80 °C / Sealed tube; Inert atmosphere
View Scheme
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

ethyl 2-(bis(2-isopropylphenoxy)phosphoryl)acetate
188945-44-0

ethyl 2-(bis(2-isopropylphenoxy)phosphoryl)acetate

A

(Z)-ethyl 3-(benzofuran-6-yl)acrylate
1499179-58-6

(Z)-ethyl 3-(benzofuran-6-yl)acrylate

B

3-(6-[2,3]dihydrobenzofuran)-2-propenoic acid
227751-62-4

3-(6-[2,3]dihydrobenzofuran)-2-propenoic acid

Conditions
ConditionsYield
Stage #1: ethyl 2-[bis(2-isopropylphenoxy)phosphoryl]acetate With N-benzyl-trimethylammonium hydroxide In tetrahydrofuran; methanol at -78℃; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;
Stage #2: benzofuran-6-carboxaldehyde In tetrahydrofuran; methanol at -78℃; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; Overall yield = 82 %; diastereoselective reaction;
A n/a
B n/a
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

(+/-)-3-(benzofuran-6-yl)-4-(2,4-dimethoxybenzyl)-4H-1'-azaspiro[[1,2,4]oxadiazole-5,3'-bicyclo[2.2.2]octane]

(+/-)-3-(benzofuran-6-yl)-4-(2,4-dimethoxybenzyl)-4H-1'-azaspiro[[1,2,4]oxadiazole-5,3'-bicyclo[2.2.2]octane]

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydroxylamine hydrochloride; potassium carbonate / ethanol; water / 20 °C
2: sodium hypochlorite / water; dichloromethane / 2 h / 0 - 20 °C
View Scheme
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

(R)-3-(benzofuran-6-yl)-4-(2,4-dimethoxybenzyl)-4H-1'-azaspiro[[1,2,4]oxadiazole-5,3'-bicyclo[2.2.2]octane]

(R)-3-(benzofuran-6-yl)-4-(2,4-dimethoxybenzyl)-4H-1'-azaspiro[[1,2,4]oxadiazole-5,3'-bicyclo[2.2.2]octane]

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; potassium carbonate / ethanol; water / 20 °C
2: sodium hypochlorite / water; dichloromethane / 2 h / 0 - 20 °C
3: ammonium hydroxide / ethanol / Resolution of racemate
View Scheme
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

(S)-3-(benzofuran-6-yl)-4-(2,4-dimethoxybenzyl)-4H-1'-azaspiro[[1,2,4]oxadiazole-5,3'-bicyclo[2.2.2]octane]

(S)-3-(benzofuran-6-yl)-4-(2,4-dimethoxybenzyl)-4H-1'-azaspiro[[1,2,4]oxadiazole-5,3'-bicyclo[2.2.2]octane]

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; potassium carbonate / ethanol; water / 20 °C
2: sodium hypochlorite / water; dichloromethane / 2 h / 0 - 20 °C
3: ammonium hydroxide / ethanol / Resolution of racemate
View Scheme

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