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Shandong Kehui Pharmaceutical Co., Ltd

Shandong Kehui Pharmaceutical Co., Ltd. is a modern high-tech pharmaceutical company that strictly complies with GMP requirements and produces high standards. The company was established in May 2017 and is located in the Yellow River Delta Medicine V

Clofarabine

Cas:123318-82-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Clofarabine Manufacturer/High quality/Best price/In stock

Cas:123318-82-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Clofarabine supplier in China

Cas:123318-82-1

Min.Order:0 Metric Ton

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Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Clofarabine CAS 123318-82-1. Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Normal temperature preservation Package:10g/bag

Superior quality Clofarabine CAS 123318-82-1 with favorable price

Cas:123318-82-1

Min.Order:10 Gram

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Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Clofarabine

Cas:123318-82-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Clofarabine 123318-82-1 GMP Manufacturer

Cas:123318-82-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Clofarabine

Cas:123318-82-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Clofarabine

Cas:123318-82-1

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Clofarabine

Cas:123318-82-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

(2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol Chemical Name : (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydr

(2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol -

Cas:123318-82-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 123318-82-1 with best quality

Cas:123318-82-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol CAS NO.:123318-82-1 Molecular formula: C10H11ClFN5O3 Molecular weight: 303.68 Appearance:White crystalline powder Storage:Store in

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Good Quality Clofarabine CAS 123318-82-1 for Acute Lymphocytic Leukemia

Cas:123318-82-1

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Clofarabine 123318-82-1

Cas:123318-82-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Clofarabine 99%

Cas:123318-82-1

Min.Order:1 Kilogram

FOB Price: $86.0 / 100.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Clofarabine CAS:123318-82-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Clofarabine CAS:123318-82-1

Cas:123318-82-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

clofarabine

Cas:123318-82-1

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Clofarabine manufacturer with low price

Cas:123318-82-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Clofarabine CAS123318-82-1123318-82-1

Cas:123318-82-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Clofarabine

Cas:123318-82-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Clofarabine

Cas:123318-82-1

Min.Order:1 Gram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Sea/Air/Courier Port:Qingdao/Shanghai,China

Clofarabine

Cas:123318-82-1

Min.Order:10 Gram

FOB Price: $1.0 / 10.0

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Clofarabine 123318-82-1

Cas:123318-82-1

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Clofarabine

Cas:123318-82-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

6-AMino-2-chloropurine-9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside

Cas:123318-82-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Clofarabine

Cas:123318-82-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Clofarabine

Cas:123318-82-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products Clofarabine

Cas:123318-82-1

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Clofarabine

Cas:123318-82-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol -

Cas:123318-82-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Synthetic route

6-amino-2-chloro-9-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-β-D-arabinofuranosyl)-9H-purine
355138-50-0

6-amino-2-chloro-9-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-β-D-arabinofuranosyl)-9H-purine

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
With methanol; sodium methylate at 15 - 20℃; for 2h;95.41%
With methanol; sodium methylate at 20℃; for 2h; pH=9 - 10; Reagent/catalyst; Green chemistry;95.5%
With methanol; sodium methylate at 0℃; for 2h;95.5%
6-amino-2-chloro-9-(2-deoxy-2-fluoro-3,5-di-O-(triisopropylsilyl)-β-D-arabinofuranosyl)-9H-purine
1234346-14-5

6-amino-2-chloro-9-(2-deoxy-2-fluoro-3,5-di-O-(triisopropylsilyl)-β-D-arabinofuranosyl)-9H-purine

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
With tetramethylammonium fluoride; acetic acid In N,N-dimethyl-formamide at 20℃;90%
With tetramethylammonium fluoride; acetic acid In N,N-dimethyl-formamide at 20℃;90%
C25H19ClF3N5O8S

C25H19ClF3N5O8S

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
With ammonia In methanol at 60℃; for 5h;90%
2-chloro-6-heptanoylamido-9-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)-9H-purine

2-chloro-6-heptanoylamido-9-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)-9H-purine

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
60%
2-deoxy-2-fluoro-α,β-D-arabinofuranose 1-phosphate

2-deoxy-2-fluoro-α,β-D-arabinofuranose 1-phosphate

2-chloroadenine
1839-18-5

2-chloroadenine

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
With recombinant E.coli purine nucleoside phosphorylase In water at 52℃; for 168h; Enzymatic reaction;42%
2,6-dichloro-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine
103884-99-7

2,6-dichloro-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
With lithium hydroxide; ammonia 1.) ethanol, RT, 3 d, 2.) acetonitrile, RT, 3 h; Yield given. Multistep reaction;
2-chloro-9-(3',5'-di-O-benzoyl-β-D-ribofuranosyl)adenine
1353040-42-2

2-chloro-9-(3',5'-di-O-benzoyl-β-D-ribofuranosyl)adenine

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: guanidine carbonate / dichloromethane; ethyl acetate / 60 °C
2.2: 80 °C
3.1: sodium methylate; methanol / 30 - 40 °C
View Scheme
Multi-step reaction with 3 steps
1: pyridine; dichloromethane / 0 - 20 °C / Inert atmosphere
2: guanidine hydrogen carbonate; triethylamine hydrofluoride / ethyl acetate / 20 - 80 °C
3: sodium methylate / methanol / 30 - 40 °C
View Scheme
Multi-step reaction with 3 steps
1: pyridine / dichloromethane / 0.5 h / -10 - 0 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; triethylamine tris(hydrogen fluoride) / toluene / 48 h / 35 - 40 °C
3: sodium methylate / methanol / 0.5 h / 30 °C
View Scheme
6-amino-2-chloro-9-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-9H-purine
1055168-98-3

6-amino-2-chloro-9-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-9H-purine

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridine; hydrazine hydrate; acetic acid / 75 - 80 °C / Inert atmosphere
2.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
3.1: guanidine carbonate / dichloromethane; ethyl acetate / 60 °C
3.2: 80 °C
4.1: sodium methylate; methanol / 30 - 40 °C
View Scheme
Multi-step reaction with 4 steps
1.1: pyridine; hydrazine hydrate; acetic acid / 75 - 80 °C / Inert atmosphere
1.2: 65 °C
2.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
3.1: guanidine carbonate / dichloromethane; ethyl acetate / 60 °C
3.2: 80 °C
4.1: sodium methylate; methanol / 30 - 40 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrazine / pyridine; acetic acid / 20 - 80 °C / Inert atmosphere
2: pyridine; dichloromethane / 0 - 20 °C / Inert atmosphere
3: guanidine hydrogen carbonate; triethylamine hydrofluoride / ethyl acetate / 20 - 80 °C
4: sodium methylate / methanol / 30 - 40 °C
View Scheme
2-chloro-9-(3',5'-di-O-benzoyl-2'-O-trifluoromethylsulfonyl-β-D-ribofuranosyl)adenine
1353040-43-3

2-chloro-9-(3',5'-di-O-benzoyl-2'-O-trifluoromethylsulfonyl-β-D-ribofuranosyl)adenine

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; triethylamine tris(hydrogen fluoride) / toluene / 48 h / 35 - 40 °C
2: sodium methylate / methanol / 0.5 h / 30 °C
View Scheme
2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide
97614-44-3

2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium iodide / acetonitrile; tert-Amyl alcohol / 24 h / 20 °C / Inert atmosphere
2: sodium methylate / methanol / 7 h / 33 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / acetonitrile; 1,2-dichloro-ethane; tert-Amyl alcohol / 19 h / 50 °C / Inert atmosphere
2.1: sodium methylate / methanol / 5 h / 20 °C / Inert atmosphere
2.2: 20 - 64 °C
View Scheme
Multi-step reaction with 3 steps
1: calcium hydride; sodium hydride / dichloromethane; acetonitrile / 20 °C / Inert atmosphere
2: ammonia / acetonitrile / 20 °C
3: sodium methylate / methanol / 0.67 h / 30 - 35 °C
View Scheme
2-deoxy-2-fluoro-α,β-D-arabinofuranose 1-phosphate (2Li+ SALT)

2-deoxy-2-fluoro-α,β-D-arabinofuranose 1-phosphate (2Li+ SALT)

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water / pH 7.5
2: recombinant E.coli purine nucleoside phosphorylase / water / 168 h / 52 °C / Enzymatic reaction
View Scheme
2-chloroadenine
1839-18-5

2-chloroadenine

1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)uracil
69123-94-0

1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)uracil

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
Stage #1: 2-chloroadenine; 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)uracil In aq. buffer at 50℃; for 0.5h; pH=6.5;
Stage #2: With nucleoside deoxyribosyltransferase enzyme (NDT enzyme) In aq. buffer at 50℃; Concentration; Solvent; Temperature; Enzymatic reaction;
2-Chloroadenosine
146-77-0

2-Chloroadenosine

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridine / acetonitrile / 0.5 h / -5 - 5 °C
1.2: Reflux
2.1: pyridine / dichloromethane / 0.5 h / -10 - 0 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine; triethylamine tris(hydrogen fluoride) / toluene / 48 h / 35 - 40 °C
4.1: sodium methylate / methanol / 0.5 h / 30 °C
View Scheme
Multi-step reaction with 4 steps
1: pyridine / acetonitrile / 0.5 h / -5 - 5 °C
2: pyridine / dichloromethane / 0.5 h / -10 - 0 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine; triethylamine tris(hydrogen fluoride) / toluene / 48 h / 35 - 40 °C
4: sodium methylate / methanol / 0.5 h / 30 °C
View Scheme
clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride; potassium dihydrogenphosphate; potassium hydroxide / water; dimethyl sulfoxide / 4 h / 58 - 61 °C / pH 7.1-7.2 / Enzymatic reaction
2.1: pyridine / acetonitrile / 0.5 h / -5 - 5 °C
2.2: Reflux
3.1: pyridine / dichloromethane / 0.5 h / -10 - 0 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine; triethylamine tris(hydrogen fluoride) / toluene / 48 h / 35 - 40 °C
5.1: sodium methylate / methanol / 0.5 h / 30 °C
View Scheme
Multi-step reaction with 5 steps
1: hydrogenchloride; potassium dihydrogenphosphate; potassium hydroxide / water; dimethyl sulfoxide / 4 h / 58 - 61 °C / pH 7.1-7.2 / Enzymatic reaction
2: pyridine / acetonitrile / 0.5 h / -5 - 5 °C
3: pyridine / dichloromethane / 0.5 h / -10 - 0 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine; triethylamine tris(hydrogen fluoride) / toluene / 48 h / 35 - 40 °C
5: sodium methylate / methanol / 0.5 h / 30 °C
View Scheme
uridine
58-96-8

uridine

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride; potassium dihydrogenphosphate; potassium hydroxide / water; dimethyl sulfoxide / 4 h / 58 - 61 °C / pH 7.1-7.2 / Enzymatic reaction
2.1: pyridine / acetonitrile / 0.5 h / -5 - 5 °C
2.2: Reflux
3.1: pyridine / dichloromethane / 0.5 h / -10 - 0 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine; triethylamine tris(hydrogen fluoride) / toluene / 48 h / 35 - 40 °C
5.1: sodium methylate / methanol / 0.5 h / 30 °C
View Scheme
Multi-step reaction with 5 steps
1: hydrogenchloride; potassium dihydrogenphosphate; potassium hydroxide / water; dimethyl sulfoxide / 4 h / 58 - 61 °C / pH 7.1-7.2 / Enzymatic reaction
2: pyridine / acetonitrile / 0.5 h / -5 - 5 °C
3: pyridine / dichloromethane / 0.5 h / -10 - 0 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine; triethylamine tris(hydrogen fluoride) / toluene / 48 h / 35 - 40 °C
5: sodium methylate / methanol / 0.5 h / 30 °C
View Scheme
1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose
14215-97-5

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose

clofarabine
123318-82-1

clofarabine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen bromide; tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / Cooling with ice
1.2: 2 h
2.1: potassium tert-butylate; calcium hydride / acetonitrile; tert-butyl alcohol / 1 h / 60 °C
2.2: 10 h / 60 °C
3.1: sodium methylate; methanol / 2 h / 0 °C
View Scheme
clofarabine
123318-82-1

clofarabine

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

6-amino-2-chloro-9-(2'-deoxy-2'-fluoro-3',5'-di-O-tert-butyldimethylsilyl-β-D-arabinofuranosyl)-9H-purine

6-amino-2-chloro-9-(2'-deoxy-2'-fluoro-3',5'-di-O-tert-butyldimethylsilyl-β-D-arabinofuranosyl)-9H-purine

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;93%
clofarabine
123318-82-1

clofarabine

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

(2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-4-fluorotetrahydrofuran-3-ol

(2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-4-fluorotetrahydrofuran-3-ol

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;91%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 8h;4.1 g
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 8h;4.1 g
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
69304-37-6

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

clofarabine
123318-82-1

clofarabine

A

2-chloro-9-[2-deoxy-2-fluoro-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]adenine
1450815-72-1

2-chloro-9-[2-deoxy-2-fluoro-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]adenine

B

2-chloro-9-[2-deoxy-2-fluoro-5-O-(1-hydroxy-1,1,3,3-tetraisopropyldisiloxane-3-yl)-β-D-arabinofuranosyl]adenine
1450815-73-2

2-chloro-9-[2-deoxy-2-fluoro-5-O-(1-hydroxy-1,1,3,3-tetraisopropyldisiloxane-3-yl)-β-D-arabinofuranosyl]adenine

C

C32H48Cl2F2N10O7Si2
1450815-74-3

C32H48Cl2F2N10O7Si2

Conditions
ConditionsYield
With pyridine at 20℃; for 24h;A 87%
B 9%
C 2%
clofarabine
123318-82-1

clofarabine

9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
20187-82-0, 20227-41-2, 64183-27-3, 123334-75-8

9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

Conditions
ConditionsYield
With ammonia; hydrogen; palladium on activated charcoal In ethanol; water at 20℃; for 18h;82%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 48h;57%
phosphoric acid-(2R-decyloxy-3-dodecyoxo)propyl ester

phosphoric acid-(2R-decyloxy-3-dodecyoxo)propyl ester

clofarabine
123318-82-1

clofarabine

[2-chloro-9-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)adenine]-5'-phosphoric acid-(2R-decyloxy-3-dodecyloxy)propyl ester

[2-chloro-9-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)adenine]-5'-phosphoric acid-(2R-decyloxy-3-dodecyloxy)propyl ester

Conditions
ConditionsYield
Stage #1: phosphoric acid-(2R-decyloxy-3-dodecyoxo)propyl ester With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride at 20 - 25℃; for 1h; Inert atmosphere;
Stage #2: clofarabine for 20h; Inert atmosphere;
Stage #3: With sodium methylate In methanol pH=7; Inert atmosphere;
76%
benzoyl chloride
98-88-4

benzoyl chloride

clofarabine
123318-82-1

clofarabine

2-chloro-N6-benzoyl-9-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)adenine

2-chloro-N6-benzoyl-9-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)adenine

Conditions
ConditionsYield
Stage #1: clofarabine With pyridine; chloro-trimethyl-silane at 0℃; for 0.5h;
Stage #2: benzoyl chloride at 20℃; for 24h;
76%
clofarabine
123318-82-1

clofarabine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

((2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonate

((2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonate

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 24h;76%
clofarabine
123318-82-1

clofarabine

phenyl(benzyloxy-L-alaninyl)phosphorochloridate
183370-70-9

phenyl(benzyloxy-L-alaninyl)phosphorochloridate

CPF448

CPF448

Conditions
ConditionsYield
With pyridine; 1-methyl-1H-imidazole In tetrahydrofuran at -80 - 20℃; for 12.2667h;66%
P,P'-methanediyl-bis-phosphonic acid tetrachloride
1499-29-2

P,P'-methanediyl-bis-phosphonic acid tetrachloride

clofarabine
123318-82-1

clofarabine

C11H12ClFN5O8P2(3-)*3Na(1+)

C11H12ClFN5O8P2(3-)*3Na(1+)

Conditions
ConditionsYield
Stage #1: P,P'-methanediyl-bis-phosphonic acid tetrachloride; clofarabine With triethyl phosphate at 0℃; Inert atmosphere;
Stage #2:
63%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

clofarabine
123318-82-1

clofarabine

(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-3-tert-butyloxycarbonyloxy-4-fluoro-2-(hydroxymethyl)oxolane

(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-3-tert-butyloxycarbonyloxy-4-fluoro-2-(hydroxymethyl)oxolane

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 18h;58%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 18h;58%
clofarabine
123318-82-1

clofarabine

6-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3,9-dihydro-purin-2-one

6-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3,9-dihydro-purin-2-one

Conditions
ConditionsYield
With lithium hydroxide; dihydrogen peroxide In water at 60℃; for 24h;48%
sodium methylate
124-41-4

sodium methylate

clofarabine
123318-82-1

clofarabine

C11H14FN5O4

C11H14FN5O4

Conditions
ConditionsYield
In methanol at 60℃; for 168h; Inert atmosphere;48%
clofarabine
123318-82-1

clofarabine

C10H12FN5O4

C10H12FN5O4

Conditions
ConditionsYield
With dihydrogen peroxide; lithium hydroxide In water at 60℃; for 24h; Inert atmosphere;48%
phosphoric acid-(2S-decyloxy-3-dodecyloxoy)propyl ester

phosphoric acid-(2S-decyloxy-3-dodecyloxoy)propyl ester

clofarabine
123318-82-1

clofarabine

[2-chloro-9-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)adenine]-5'-phosphoric acid-(2S-decyloxy-3-dodecyloxy)propyl ester

[2-chloro-9-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)adenine]-5'-phosphoric acid-(2S-decyloxy-3-dodecyloxy)propyl ester

Conditions
ConditionsYield
Stage #1: phosphoric acid-(2S-decyloxy-3-dodecyloxoy)propyl ester With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride at 20 - 25℃; Inert atmosphere;
Stage #2: clofarabine Inert atmosphere;
Stage #3: With sodium methylate In methanol pH=7; Inert atmosphere;
28%
clofarabine
123318-82-1

clofarabine

C10H10ClN5O3

C10H10ClN5O3

Conditions
ConditionsYield
With sodium hydroxide In dimethyl sulfoxide at 54℃; for 3.5h; Inert atmosphere;25%
C13H19ClNO4P*ClH

C13H19ClNO4P*ClH

clofarabine
123318-82-1

clofarabine

C23H29ClFN6O7P

C23H29ClFN6O7P

Conditions
ConditionsYield
With copper(II) bis(trifluoromethanesulfonate); triethylamine In tetrahydrofuran at 20℃; for 12h;15%
2-fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
134217-15-5

2-fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine

clofarabine
123318-82-1

clofarabine

C20H21ClF2N10O6

C20H21ClF2N10O6

Conditions
ConditionsYield
With sodium hydroxide In water at 80℃; for 1.9h; Inert atmosphere;0.8%
clofarabine
123318-82-1

clofarabine

A

2-chloroadenine
1839-18-5

2-chloroadenine

B

2-deoxy-2-fluoro-α-D-arabinofuranose 1-phosphate
850883-62-4

2-deoxy-2-fluoro-α-D-arabinofuranose 1-phosphate

Conditions
ConditionsYield
With E. coli purine nucleoside phosphorylase Enzyme kinetics; Substitution;
clofarabine
123318-82-1

clofarabine

(2R,3R,4S,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

(2R,3R,4S,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 82 percent / H2; NH3 / Pd/C / ethanol; H2O / 18 h / 20 °C
2.1: pyridine / 18 h / 20 °C
2.2: 72 percent / pyridine / 18 h / 20 °C
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