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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Ataluren

Cas:775304-57-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Ataluren CAS NO.775304-57-9

Cas:775304-57-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Ataluren (PTC124) 775304-57-9 GMP Manufacturer

Cas:775304-57-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ataluren

Cas:775304-57-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Ataluren (PTC124) In stock

Cas:775304-57-9

Min.Order:1 Gram

FOB Price: $1000.0 / 1300.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 775304-57-9 with competitive price

Cas:775304-57-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:room temperature Package:25kg/drum Application:APIs Transportation:Express/Sea/Air Port:any port in china

Ataluren factory price

Cas:775304-57-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ataluren 775304-57-9

Cas:775304-57-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

Ataluren (PTC124)

Cas:775304-57-9

Min.Order:1 Gram

FOB Price: $10.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Ataluren (PTC124)CAS:775304-57-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interme

Ataluren (PTC124)CAS:775304-57-9

Cas:775304-57-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ataluren

Cas:775304-57-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

API name: Ataluren Certificates: GMP, DMF CAS No.: 775304-57-9 Chemical name: 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid Ataluren Benzoic acid, 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]- PTC124 Formula: C15H9FN2O

Ataluren

Cas:775304-57-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ataluren

Cas:775304-57-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Ataluren CAS NO.775304-57-9

Cas:775304-57-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

PTC124 Ataluren 775304-57-9

Cas:775304-57-9

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Tianjin Kind Pharma Co., Ltd.

Factory direct sales, accept customization. PTC-124 is a nonaminoglycoside that has been reported to induce ribosomes to read through premature nonsense stop signals on mRNA, allowing the production of full-length functional proteins. Kind Pharma h

Ataluren

Cas:775304-57-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of sci

PTC124

Cas:775304-57-9

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid

Cas:775304-57-9

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ataluren

Cas:775304-57-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Ataluren (PTC124)/High quality/Best price

Cas:775304-57-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Benzoic acid,3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-

Cas:775304-57-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferAtaluren (PTC124)

Cas:775304-57-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Ataluren(PTC124);3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoicacid

Cas:775304-57-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Ataluren CAS NO.775304-57-9

Cas:775304-57-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid

Cas:775304-57-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Ataluren (PTC124)

Cas:775304-57-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Ataluren (PTC124)

Cas:775304-57-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Ataluren CAS NO.775304-57-9

Cas:775304-57-9

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Ataluren (PTC124)

Cas:775304-57-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Ataluren CAS NO.775304-57-9

Cas:775304-57-9

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Synthetic route

3-((5-(2-fluorophenyl))-(1,2,4-oxadiazol-3-yl))benzoic acid methyl ester
775304-60-4

3-((5-(2-fluorophenyl))-(1,2,4-oxadiazol-3-yl))benzoic acid methyl ester

Conditions
ConditionsYield
Stage #1: 3-((5-(2-fluorophenyl))-(1,2,4-oxadiazol-3-yl))benzoic acid methyl ester With sodium hydroxide; water at 100℃; for 2h; Heating / reflux;
Stage #2: With hydrogenchloride In water
96%
Stage #1: 3-((5-(2-fluorophenyl))-(1,2,4-oxadiazol-3-yl))benzoic acid methyl ester With sodium hydroxide; water In tetrahydrofuran at 100℃; for 2h; Heating / reflux;
Stage #2: With hydrogenchloride In water
96%
Stage #1: 3-((5-(2-fluorophenyl))-(1,2,4-oxadiazol-3-yl))benzoic acid methyl ester With sodium hydroxide; water In tetrahydrofuran at 100℃; for 2h; Heating / reflux;
Stage #2: With hydrogenchloride In water
96%

Conditions
ConditionsYield
Stage #1: 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzaldehyde With potassium dihydrogenphosphate; dihydrogen peroxide In water; acetonitrile at 20 - 30℃;
Stage #2: With sodium chlorite In water; acetonitrile at 0 - 30℃; for 5h;
90%

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
In tert-butyl alcohol at 80℃; for 24h;88.4%
5-(2-fluorophenyl)-3-(3-methylphenyl)-1,2,4-oxadiazole
692771-01-0

5-(2-fluorophenyl)-3-(3-methylphenyl)-1,2,4-oxadiazole

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
With basic cobalt(II) carbonate; sodium bromide In acetic acid at 95℃; for 11h; Green chemistry;85%
With pyridine; potassium permanganate In water at 85℃; for 6.5h;40%
2-Fluorobenzoyl chloride
393-52-2

2-Fluorobenzoyl chloride

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Stage #1: 3-Cyanobenzoic acid With hydroxylamine In water; tert-butyl alcohol at 38 - 41℃; for 21h;
Stage #2: 2-Fluorobenzoyl chloride With triethylamine In water; tert-butyl alcohol at 27 - 40℃; for 7h;
Stage #3: With hydrogenchloride; water Product distribution / selectivity; more than 3 stages;
76%
3-(N'-hydroxycarbamimidoyl)benzoic acid
199447-10-4

3-(N'-hydroxycarbamimidoyl)benzoic acid

o-fluoro-benzoic acid
445-29-4

o-fluoro-benzoic acid

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
With tetrachloromethane; diethoxymethylsilane; Bis(p-nitrophenyl) phosphate; triphenylphosphine In toluene at 120℃; for 24h; Reflux; Large scale;65%
3-(N-hydroxycarbamimidoyl)-benzoic acid methyl ester
1141475-82-2, 1227154-43-9, 775304-79-5

3-(N-hydroxycarbamimidoyl)-benzoic acid methyl ester

2-Fluorobenzoyl chloride
393-52-2

2-Fluorobenzoyl chloride

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: boron trifluoride diethyl etherate / 1,4-dioxane / 12.5 h / 0 °C / Reflux
2: sodium hydroxide; water / ethanol / 3 h / 20 °C
View Scheme
C15H13FN2O

C15H13FN2O

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydroxylamine hydrochloride; acetic acid / 3.5 h / 80 °C
2: pyridine; potassium permanganate / water / 6.5 h / 85 °C
View Scheme
o-fluoro-benzoic acid
445-29-4

o-fluoro-benzoic acid

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C
2: hydroxylamine hydrochloride; acetic acid / 3.5 h / 80 °C
3: pyridine; potassium permanganate / water / 6.5 h / 85 °C
View Scheme
3-methylbenzenecarboximidamide hydrochloride
20680-59-5

3-methylbenzenecarboximidamide hydrochloride

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C
2: hydroxylamine hydrochloride; acetic acid / 3.5 h / 80 °C
3: pyridine; potassium permanganate / water / 6.5 h / 85 °C
View Scheme
3-Cyanobenzoic acid
1877-72-1

3-Cyanobenzoic acid

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 4.33 h / 20 °C
2.1: hydroxylamine / ethanol; water / 1 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.33 h / 20 °C
4.1: toluene / 22 h / 5 - 130 °C / Dean-Stark
5.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate; hydroxylamine hydrochloride / water; ethanol / 3 h / Reflux
2.1: potassium carbonate / water; toluene / 0.08 h / 20 - 30 °C
2.2: 1 h / 0 - 10 °C
3.1: tert-butyl alcohol / 24 h / 80 °C
View Scheme
methyl 3-cyanobenzoate
13531-48-1

methyl 3-cyanobenzoate

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydroxylamine / ethanol; water / 1 h / 100 °C
2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.33 h / 20 °C
3: toluene / 22 h / 5 - 130 °C / Dean-Stark
4: sodium hydroxide; water / tetrahydrofuran / 2 h / 100 °C
View Scheme
Multi-step reaction with 4 steps
1: hydroxylamine / ethanol; water / 20 °C / Reflux
2: trifluoroacetic acid / 0.58 h / 20 - 60 °C
3: palladium diacetate; triphenylphosphine; silver(I) acetate / toluene / 0.5 h / 150 °C / Microwave irradiation; Sealed tube
4: lithium hydroxide monohydrate / water; tetrahydrofuran / 1 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: hydroxylamine / ethanol; water / 1 h / 100 °C
2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.33 h / 5 - 20 °C
3: toluene / 22 h / 5 - 130 °C / Dean-Stark apparatus
4: sodium hydroxide; water / tetrahydrofuran / 2 h / 100 °C
View Scheme
Multi-step reaction with 4 steps
1: hydroxylamine hydrochloride; sodium ethanolate / ethanol / 20 h / 20 °C
2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 5 - 20 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / 20 °C
4: lithium hydroxide / tetrahydrofuran; water / 24 h / 20 °C
View Scheme
3-(carbamimidoyl)benzoic acid methyl ester
15676-11-6

3-(carbamimidoyl)benzoic acid methyl ester

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.33 h / 20 °C
2: toluene / 22 h / 5 - 130 °C / Dean-Stark
3: sodium hydroxide; water / tetrahydrofuran / 2 h / 100 °C
View Scheme
methyl 3-(1,2,4-oxadiazol-3-yl)benzoate

methyl 3-(1,2,4-oxadiazol-3-yl)benzoate

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium diacetate; triphenylphosphine; silver(I) acetate / toluene / 0.5 h / 150 °C / Microwave irradiation; Sealed tube
2: lithium hydroxide monohydrate / water; tetrahydrofuran / 1 h / 20 °C
View Scheme
3-(N-hydroxycarbamimidoyl)-benzoic acid methyl ester
1141475-82-2, 1227154-43-9, 775304-79-5

3-(N-hydroxycarbamimidoyl)-benzoic acid methyl ester

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: trifluoroacetic acid / 0.58 h / 20 - 60 °C
2: palladium diacetate; triphenylphosphine; silver(I) acetate / toluene / 0.5 h / 150 °C / Microwave irradiation; Sealed tube
3: lithium hydroxide monohydrate / water; tetrahydrofuran / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.33 h / 5 - 20 °C
2: toluene / 22 h / 5 - 130 °C / Dean-Stark apparatus
3: sodium hydroxide; water / tetrahydrofuran / 2 h / 100 °C
View Scheme
3-cyanobenzaldehyde dimethyl acetal

3-cyanobenzaldehyde dimethyl acetal

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydroxylamine / water; methanol / 2.5 h / 50 °C
2.1: sodium hydrogencarbonate / water / 0.08 h / 20 - 30 °C
2.2: 1 h / 20 - 30 °C
3.1: toluene / 18 h / 85 °C
4.1: potassium dihydrogenphosphate; dihydrogen peroxide / water; acetonitrile / 20 - 30 °C
4.2: 5 h / 0 - 30 °C
View Scheme
3-Cyanobenzaldehyde
24964-64-5

3-Cyanobenzaldehyde

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride / water / 3.08 h / 20 - 45 °C
2.1: hydroxylamine / water; methanol / 2.5 h / 50 °C
3.1: sodium hydrogencarbonate / water / 0.08 h / 20 - 30 °C
3.2: 1 h / 20 - 30 °C
4.1: toluene / 18 h / 85 °C
5.1: potassium dihydrogenphosphate; dihydrogen peroxide / water; acetonitrile / 20 - 30 °C
5.2: 5 h / 0 - 30 °C
View Scheme
3-(dimethoxymethyl)-N'-hydroxybenzimidamide

3-(dimethoxymethyl)-N'-hydroxybenzimidamide

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / water / 0.08 h / 20 - 30 °C
1.2: 1 h / 20 - 30 °C
2.1: toluene / 18 h / 85 °C
3.1: potassium dihydrogenphosphate; dihydrogen peroxide / water; acetonitrile / 20 - 30 °C
3.2: 5 h / 0 - 30 °C
View Scheme
N'-((2-fluorobenzoyl)oxy)-3-formylbenzimidamide

N'-((2-fluorobenzoyl)oxy)-3-formylbenzimidamide

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene / 18 h / 85 °C
2.1: potassium dihydrogenphosphate; dihydrogen peroxide / water; acetonitrile / 20 - 30 °C
2.2: 5 h / 0 - 30 °C
View Scheme
3-(N-2-fluorobenzoylcarbamimidoyl)-benzoic acid methyl ester
775304-80-8

3-(N-2-fluorobenzoylcarbamimidoyl)-benzoic acid methyl ester

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene / 22 h / 5 - 130 °C / Dean-Stark apparatus
2: sodium hydroxide; water / tetrahydrofuran / 2 h / 100 °C
View Scheme
3-(N-hydroxyamidino)benzoic acid methyl ester
1141475-82-2, 1227154-43-9, 775304-79-5

3-(N-hydroxyamidino)benzoic acid methyl ester

ataluren
775304-57-9

ataluren

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 5 - 20 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / 20 °C
3: lithium hydroxide / tetrahydrofuran; water / 24 h / 20 °C
View Scheme
ataluren
775304-57-9

ataluren

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid sodium salt

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid sodium salt

Conditions
ConditionsYield
With sodium hydroxide; water at 100℃; for 2h; Heating / reflux;96%
With sodium hydroxide In ethanol; water
ataluren
775304-57-9

ataluren

5-(2-fluorophenyl)-3-(3-fluorophenyl)-1,2,4-oxadiazole

5-(2-fluorophenyl)-3-(3-fluorophenyl)-1,2,4-oxadiazole

Conditions
ConditionsYield
Stage #1: ataluren With tetrakis(acetonitrile)copper(I)tetrafluoroborate; tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 23℃; for 0.5h; Sealed tube; Inert atmosphere;
Stage #2: In acetonitrile at 35℃; for 24h; Irradiation; Sealed tube; Inert atmosphere;
45%
ataluren
775304-57-9

ataluren

2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline
3416-93-1

2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline

N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzamide

N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzamide

Conditions
ConditionsYield
Stage #1: ataluren With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h; Inert atmosphere;
Stage #2: With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 2h; Inert atmosphere;
Stage #3: 2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline In dichloromethane at 20℃; for 72h; Inert atmosphere;
25%
ataluren
775304-57-9

ataluren

PTC124-AMP
1227154-38-2

PTC124-AMP

Conditions
ConditionsYield
With Photinus pyralis luciferase aq. buffer; Enzymatic reaction;
ataluren
775304-57-9

ataluren

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid magnesium salt

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid magnesium salt

Conditions
ConditionsYield
With magnesium methanolate In methanol; dichloromethane Reagent/catalyst; Solvent;
ataluren
775304-57-9

ataluren

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid potassium salt

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid potassium salt

Conditions
ConditionsYield
With potassium hydroxide In tetrahydrofuran; water
ataluren
775304-57-9

ataluren

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid tromethamine salt

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid tromethamine salt

Conditions
ConditionsYield
In methanol; acetone Solvent;
ataluren
775304-57-9

ataluren

L-lysine
56-87-1

L-lysine

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid L-lysine salt

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid L-lysine salt

Conditions
ConditionsYield
In tetrahydrofuran; water
ataluren
775304-57-9

ataluren

L-arginine
74-79-3

L-arginine

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid L-arginine salt

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid L-arginine salt

Conditions
ConditionsYield
In ethanol; water Sonication;
ataluren
775304-57-9

ataluren

L-histidine
71-00-1

L-histidine

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid L-histidine salt

3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid L-histidine salt

Conditions
ConditionsYield
In ethanol; water Solvent; Sonication;

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