Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:77943-39-6
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:77943-39-6
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inquiry(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE CAS:77943-39-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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Min.Order:10 Gram
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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Min.Order:1 Gram
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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inquirybulk production Chemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical manufacturing for overseas customers, in the field of API, pharmaceutical intermediates, chemical intermediates, fine
Cas:77943-39-6
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FOB Price: $2.0 / 4.0
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bag, 1kg/bag or as per your request Application:Chiral auxiliaries Transportation:By exp
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Min.Order:100 Gram
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiryAcmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea
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inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate
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inquiryWe are committed to providing our customers with the best products and services at the most competitive prices.Appearance:off-white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as prima
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inquiry(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express
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inquiryGood Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryBest Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP
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inquiry1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
Cas:77943-39-6
Min.Order:10 Milligram
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inquiry
Cas:77943-39-6
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryChangzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa
Cas:77943-39-6
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Subsidiary of Institute of Chemistry, Henan Academy of Sciences, national research platform;2. About 30 years’ experience in this field since 1983;3. An experienced R&D team consisting of Doctors and Masters;4. Various types of analytical instrume
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Type:Lab/Research institutions
inquiryN,O-dimethylhydroxylamine*hydrochloride
(4R,5S)-3-((E)-(2R,3R)-3-Hydroxy-2,4-dimethyl-hept-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one
A
(E)-(2R,3R)-3-Hydroxy-2,4-dimethyl-hept-4-enoic acid methoxy-methyl-amide
B
4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: N,O-dimethylhydroxylamine*hydrochloride With trimethylaluminum In tetrahydrofuran; toluene at 0 - 20℃; Stage #2: (4R,5S)-3-((E)-(2R,3R)-3-Hydroxy-2,4-dimethyl-hept-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one In tetrahydrofuran; toluene at 0℃; for 1h; | A 100% B 272 mg |
N,O-dimethylhydroxylamine*hydrochloride
mephenoxalone
4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
With hydrogenchloride; AlMe3 In tetrahydrofuran; hexane; dichloromethane | 100% |
With hydrogenchloride; AlMe3 In tetrahydrofuran; hexane; dichloromethane | 100% |
With hydrogenchloride; AlMe3 In tetrahydrofuran; hexane; dichloromethane | 100% |
carbon monoxide
(1S,2R)-(+)-norphedrine
4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
With copper diacetate; air; palladium diacetate In toluene under 760 Torr; for 2h; Heating; | 99% |
With sodium acetate; palladium diacetate In acetonitrile at 20℃; under 760 Torr; Electrolysis; | 86% |
N,O-dimethylhydroxylamine*hydrochloride
(2'R,3'S,4'S,4R,5S)-3-[3'-hydroxy-5'-(4"-methoxyphenyl)methoxy-2',4'-dimethylpentanoyl]-5-phenyl-4-methyl-2-oxazolidinone
A
4-methyl-5-phenyloxazolidin-2-one
B
(2R,3S,4S)-3-hydroxy-5-(4-methoxybenzyloxy)-2,4-dimethylpentanoic acid methoxymethylamide
Conditions | Yield |
---|---|
Stage #1: N,O-dimethylhydroxylamine*hydrochloride With trimethylaluminum In tetrahydrofuran; hexane at 0 - 20℃; Metallation; Stage #2: (2'R,3'S,4'S,4R,5S)-3-[3'-hydroxy-5'-(4"-methoxyphenyl)methoxy-2',4'-dimethylpentanoyl]-5-phenyl-4-methyl-2-oxazolidinone In tetrahydrofuran; hexane at -20℃; for 2.5h; Substitution; Further stages.; | A 80% B 98% |
carbon dioxide
(1S,2R)-(+)-norphedrine
4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
With triethylamine; acetyl chloride In acetonitrile at -40 - 25℃; | 97% |
Stage #1: carbon dioxide; (1S,2R)-(+)-norphedrine With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 0.75h; Stage #2: With tributylphosphine; di-tert-butyl-diazodicarboxylate In acetonitrile at 0℃; for 0.333333h; Mitsunobu reaction; | 84% |
With tetramethylphenylguanidine; chlorophosphoric acid diphenyl ester In acetonitrile at -40 - 20℃; | 82% |
Stage #1: carbon dioxide; (1S,2R)-(+)-norphedrine With N(Et)4(1+)*(2-pyrrolidone-anion) In acetonitrile at 20℃; for 1h; Carboxylation; Stage #2: With p-toluenesulfonyl chloride In acetonitrile at 20℃; Cyclization; Further stages.; | 79% |
(4R,5S)-(+)-(5-benzyloxy-2-fluoro-3-(E)-pentenoyl)-4-methyl-5-phenyl-2-oxazolidinone
A
4-methyl-5-phenyloxazolidin-2-one
B
5-O-benzyl-2-deoxy-2-fluoro-L-γ-xylonic lactone
C
5-O-benzyl-2-deoxy-2-fluoro-D-γ-xylonic lactone
Conditions | Yield |
---|---|
With osmium(VIII) oxide; trimethylamine-N-oxide In water; acetone; tert-butyl alcohol at 20℃; for 2h; Oxidation; cyclization; | A n/a B 94% C 86% |
Conditions | Yield |
---|---|
With potassium carbonate at 110℃; for 6h; | 93% |
Stage #1: bis(phenyl) carbonate; Acutrim With potassium carbonate at 100℃; for 6h; Stage #2: In methanol for 0.5h; Heating; |
Conditions | Yield |
---|---|
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran at 20℃; for 2h; | A 92% B 79% |
(4R,5S)-3-[(Z)-(R)-2-(tert-Butyl-diphenyl-silanyloxy)-dec-4-enoyl]-4-methyl-5-phenyl-oxazolidin-2-one
A
4-methyl-5-phenyloxazolidin-2-one
B
(2R,4Z)-2(tert-Butyldiphenylsiloxy)-4-decen-1-ol
Conditions | Yield |
---|---|
With lithium borohydride; water In tetrahydrofuran; diethyl ether Product distribution; Ambient temperature; other reducing reagents; var. N-acyloxazolidinones; | A n/a B 90% |
(4R,5S)-3-((R)-2-Benzyl-4-methyl-pent-3-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one
A
4-methyl-5-phenyloxazolidin-2-one
B
4-methyl-2(R)-(phenylmethyl)-3-penten-1-ol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at -78 - 0℃; for 1.5h; | A 70% B 90% |
(2'S,4R,5S)-3-(2'-methyl-3'-phenylpropionyl)-4-methyl-5-phenyloxazolidin-2-one
A
4-methyl-5-phenyloxazolidin-2-one
B
(S)-2-methyl-3-phenylpropan-1-ol
Conditions | Yield |
---|---|
With Cp*RuCl{(C6H5)2P-(CH2)2NH2-κ2-P,N}; potassium tert-butylate; hydrogen In isopropyl alcohol at 80℃; under 22502.3 Torr; for 20h; Autoclave; optical yield given as %ee; | A 89% B 90% |
(4R,5S)-3-[(2S)-2-{(2S)-N-benzyloxycarbonylpyrrolidin-2-yl}propanoyl]-4-methyl-5-phenyl-2-oxazolidinone
A
4-methyl-5-phenyloxazolidin-2-one
B
(2S)-2-[(2S)-1-benzyloxycarbonylpyrrolidin-2-yl]-1-propanol
Conditions | Yield |
---|---|
With sodium tetrahydroborate In tetrahydrofuran; water at 5℃; for 15h; | A 97 mg B 88% |
(4R,5S,2'R,3'R,2"S)-3-[3'-(N-tert-butoxycarbonyl-2"-pyrrolidinyl)-3"-hydroxy-2'-methylpropanoyl]-4-methyl-5-phenyl-2-oxazolidinone
A
4-methyl-5-phenyloxazolidin-2-one
B
<1R-(1α,2β,7aα)>-Hexahydro-1-hydroxy-2-methyl-3-oxo-1H-pyrrolizine
Conditions | Yield |
---|---|
Stage #1: (4R,5S,2'R,3'R,2"S)-3-[3'-(N-tert-butoxycarbonyl-2"-pyrrolidinyl)-3"-hydroxy-2'-methylpropanoyl]-4-methyl-5-phenyl-2-oxazolidinone With trifluoroacetic acid at 20℃; for 0.333333h; Stage #2: With potassium carbonate In ethanol; water at 0℃; for 1.5h; | A n/a B 86% |
(4R,5S)-3-<(2S)-1-oxo-2,4-dimethylpent-4-enyl>-4-methyl-5-phenyloxazolidin-2-one
A
4-methyl-5-phenyloxazolidin-2-one
B
(S)-(-)-2,4-dimethylpent-4-en-1-ol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In diethyl ether at 0℃; for 0.0833333h; | A n/a B 85% |
(1S,2R)-(+)-norphedrine
4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: (1S,2R)-(+)-norphedrine; tetraethylammonium peroxycarbonate In acetonitrile at 20℃; for 2h; Acylation; Stage #2: With p-toluenesulfonyl chloride In acetonitrile at 25℃; for 10h; Cyclization; | 85% |
carbon dioxide
(1S,2R)-(+)-norphedrine
p-toluenesulfonyl chloride
A
4-methyl-5-phenyloxazolidin-2-one
B
N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]-4-methylbenzenesulfonamide
Conditions | Yield |
---|---|
Stage #1: (1S,2R)-(+)-norphedrine In acetonitrile at 20℃; Electrolysis; Stage #2: carbon dioxide for 1h; Stage #3: p-toluenesulfonyl chloride at 20℃; | A 85% B 14% |
(1S,2R)-(+)-norphedrine
Diethyl carbonate
4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
With potassium carbonate In toluene at 110℃; Inert atmosphere; Large scale reaction; | 84.3% |
With potassium carbonate at 150℃; for 2.5h; | 83% |
MCM-41-TBD; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine for 24h; Heating; | 59% |
(4R,5S)-3-<(2R)-1-oxo-2-<<(phenylmethyl)thio>methyl>-3-phenylpropyl>-4-methyl-5-phenyl-2-oxazolidinone
A
4-methyl-5-phenyloxazolidin-2-one
B
(2R)-2-<<(phenylmethyl)thio>methyl>-3-phenylpropanoic acid benzyl ester
Conditions | Yield |
---|---|
With lithium benzyloxide In tetrahydrofuran; hexane at 0℃; for 1.5h; | A 75% B 83% |
C21H29NO3
A
(2R,3S)-2,3,7-trimethyl-6-octen-1-ol
B
4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
With sodium tetrahydroborate In tetrahydrofuran; water at 20℃; for 5h; | A 81% B 83% |
ethyl potassium malonate
A
4-methyl-5-phenyloxazolidin-2-one
B
ethyl (R)-5-methyl-3-oxo-octanoate
Conditions | Yield |
---|---|
Stage #1: C17H23NO3; ethyl potassium malonate With triethylamine; magnesium chloride In acetonitrile at 80℃; for 20h; Stage #2: With hydrogenchloride In water at 10℃; Further stages.; | A n/a B 83% |
(4R,5S)-4-methyl-3-((S)-2-methylpent-4-enoyl)-5-phenyloxazolidin-2-one
A
4-methyl-5-phenyloxazolidin-2-one
B
(S)-(-)-2-methyl-4-penten-1-ol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran -70 deg C, 40 min; -78 deg C, 1 h; -78 to -20 deg C, 2 h; | A n/a B 82% |
(1S,2S)-2-amino-1-phenylpropanol
Diethyl carbonate
4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
With potassium carbonate In toluene at 130℃; Heating; | 80% |
N,O-dimethylhydroxylamine*hydrochloride
(2'R,3'S,4R,5S)-3-(3'-hydroxy-2'-methyl-4'-phenylbutanoyl)-4-methyl-5-phenyloxazolidin-2-one
A
4-methyl-5-phenyloxazolidin-2-one
B
(2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide
Conditions | Yield |
---|---|
With trimethylaluminum In dichloromethane at 0 - 4℃; for 3h; | A n/a B 78% |
(4R,5S)-(+)-3-[(2R)-2-isopropyl-5-methyl-1-oxohex-5-en-1-yl]-4-methyl-5-phenyl-2-oxazolidinone
A
4-methyl-5-phenyloxazolidin-2-one
B
(R)-(+)-2-isopropyl-5-methylhex-5-ene-1-carboxylic acid
Conditions | Yield |
---|---|
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran; water at 20℃; for 16h; cleavage; | A n/a B 75% |
carbon dioxide
(1S,2R)-(+)-norphedrine
diethyl chlorophosphate
A
4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
With tetramethylphenylguanidine In acetonitrile at -40 - 20℃; | A 55% B n/a |
With N,N,N',N'-tetramethyl-N-phenylguanidine In acetonitrile at -40 - 25℃; | A 55% B 22% |
benzyl N-(1H-benzotriazol-1-ylmethyl)carbamate
(4R,5S)-4-methyl-5-phenyl-3-phenylacetyl-oxazolidin-2-one
A
4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran | A 20% B 54% C 2% |
(4R,5S)-4-methyl-5-phenyl-3-phenylacetyl-oxazolidin-2-one
A
4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
With benzyl N-(1H-benzotriazol-1-ylmethyl)carbamate; lithium diisopropyl amide In tetrahydrofuran | A 20% B 54% C 2% |
Acetic acid (1S,2R)-1-ethyl-2-methyl-3-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl ester
A
4-methyl-5-phenyloxazolidin-2-one
B
(2S,3R,6R,7S)-7-Ethyl-3,6-dimethyl-2-phenyl-1,8-dioxa-4-aza-cycloundecane-5,9,11-trione
C
(5R,6S)-6-Ethyl-4-hydroxy-5-methyl-5,6-dihydro-pyran-2-one
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 2h; | A 45% B 43% C 37% |
Conditions | Yield |
---|---|
at 180 - 200℃; for 4h; Further byproducts given; | A n/a B 40% C n/a D n/a |
(4R,5S)-(+)-3-[(2R)-2-isopropyl-5-methyl-1-oxohex-5-en-1-yl]-4-methyl-5-phenyl-2-oxazolidinone
A
4-methyl-5-phenyloxazolidin-2-one
B
(R)-(+)-2-isopropyl-5-methylhex-5-en-1-ol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at -78 - 0℃; Reduction; | A 25% B 33% C 39% |
4-methyl-5-phenyloxazolidin-2-one
(R)-6-cyclohexyl-4-methylhexanoic acid
Conditions | Yield |
---|---|
Stage #1: (R)-6-cyclohexyl-4-methylhexanoic acid With pivaloyl chloride; triethylamine In tetrahydrofuran at 0℃; for 1h; Stage #2: 4-methyl-5-phenyloxazolidin-2-one With lithium chloride In tetrahydrofuran at 0 - 20℃; | 100% |
4-methyl-5-phenyloxazolidin-2-one
pent-4-enoyl chloride
(4R,5S)-4-methyl-3-pent-4-enoyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; Inert atmosphere; Stage #2: pent-4-enoyl chloride In tetrahydrofuran; hexane at -78 - 20℃; for 2h; Inert atmosphere; | 99% |
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; Inert atmosphere; Stage #2: pent-4-enoyl chloride In tetrahydrofuran; hexane at 0 - 20℃; for 0.5h; Inert atmosphere; | 99% |
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.583333h; Stage #2: pent-4-enoyl chloride In tetrahydrofuran; hexane at -78 - -20℃; Further stages.; | 86% |
With n-butyllithium 1.) THF, -78 deg C, 1 h, 2.) 20 deg C, 24 h; Yield given. Multistep reaction; |
4-methyl-5-phenyloxazolidin-2-one
(Z)-Dec-4-enoyl chloride
(4R,5S)-3-((Z)-Dec-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran at -78 - -10℃; | 99% |
4-methyl-5-phenyloxazolidin-2-one
acetyl chloride
(4R,5S)-3-acetyl-4-methyl-5-phenyl-2-oxazolidinone
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran at 0℃; | 99% |
With n-butyllithium In tetrahydrofuran 1.) -78 deg C, 20 min, 2.) r.t., 20 min; | 90% |
4-methyl-5-phenyloxazolidin-2-one
butyryl chloride
(4R,5S)-(+)-4-methyl-3-(1'-oxobutyl)-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane Stage #2: butyryl chloride In tetrahydrofuran; hexane at 20℃; for 2h; | 99% |
With n-butyllithium In tetrahydrofuran at -78℃; | 91% |
With n-butyllithium 1.) THF, -78 deg C, 1 h, 2.) 20 deg C, 24 h; Yield given. Multistep reaction; |
4-methyl-5-phenyloxazolidin-2-one
isopentanoyl chloride
(4R,5S)-(+)-3-[3-methyl-1-oxobut-1-yl]-4-methyl-5-phenyl-2-oxazolidinone
Conditions | Yield |
---|---|
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane Stage #2: isopentanoyl chloride In tetrahydrofuran; hexane at 20℃; for 2h; | 99% |
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere; Stage #2: isopentanoyl chloride In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; | 99% |
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h; Stage #2: isopentanoyl chloride In tetrahydrofuran; hexachloroethane at -78℃; for 0.5h; | 39% |
With n-butyllithium 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, from -78 deg C to RT, 30 min; Yield given. Multistep reaction; | |
With n-butyllithium In tetrahydrofuran at -78 - 20℃; |
4-methyl-5-phenyloxazolidin-2-one
1-iodo-2,2-dimethyl-1,2-propadiene
Conditions | Yield |
---|---|
With potassium phosphate; copper(I) thiophene-2-carboxylate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane In toluene at 85℃; for 5h; | 99% |
4-methyl-5-phenyloxazolidin-2-one
cyclopentanepropanoyl chloride
(4R,5S)-3-(3-cyclopentylpropanoyl)-4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 1.5h; | 99% |
4-methyl-5-phenyloxazolidin-2-one
propionyl chloride
(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; | 98% |
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane Stage #2: propionyl chloride In tetrahydrofuran; hexane at 20℃; for 2h; | 98% |
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: propionyl chloride In tetrahydrofuran; hexane at -78 - -50℃; for 2h; | 98% |
4-methyl-5-phenyloxazolidin-2-one
isobutyryl chloride
Conditions | Yield |
---|---|
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran at -78℃; for 0.75h; deprotonation; Stage #2: isobutyryl chloride In tetrahydrofuran at -78℃; for 2h; Acylation; | 98% |
4-methyl-5-phenyloxazolidin-2-one
Hexanoyl chloride
(4R,5S)-3-hexanoyl-4-methyl-5-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran at -78℃; | 97% |
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h; Stage #2: Hexanoyl chloride In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #3: With sodium hydroxide In tetrahydrofuran; hexane; water | 72% |
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane; ethyl acetate at -78℃; for 0.166667h; Stage #2: Hexanoyl chloride In tetrahydrofuran; hexane at -78 - 20℃; | 72% |
4-methyl-5-phenyloxazolidin-2-one
propionic acid anhydride
(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one
Conditions | Yield |
---|---|
With electrogenerated base from 2-pyrrolidone; tetraethylammonium perchlorate In acetonitrile at 20℃; | 97% |
With dmap; triethylamine In tetrahydrofuran for 1h; Ambient temperature; | 73% |
With 2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; N-ethyl-N,N-diisopropylamine In chloroform-d1 at 50℃; for 3h; Inert atmosphere; |
4-methyl-5-phenyloxazolidin-2-one
4-methylvaleroyl chloride
(4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyl-oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78 - 0℃; for 0.25h; Inert atmosphere; Stage #2: 4-methylvaleroyl chloride In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; | 97% |
With n-butyllithium; sodium hydrogencarbonate In tetrahydrofuran; hexanes at -78 - 0℃; for 1.41667h; Argon atmosphere; | 82% |
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h; Stage #2: 4-methylvaleroyl chloride In tetrahydrofuran; hexane at -78℃; for 0.5h; | 38% |
4-methyl-5-phenyloxazolidin-2-one
3-(4,4-dimethyl-heptanoyl)-(R)-4-methyl-(S)-5-phenyl-oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: 4,4-dimethyl-heptanoic acid With pivaloyl chloride; triethylamine In tetrahydrofuran at 0℃; for 1h; Stage #2: 4-methyl-5-phenyloxazolidin-2-one With lithium chloride In tetrahydrofuran for 18h; | 95% |
4-methyl-5-phenyloxazolidin-2-one
4,4-dimethyl-heptanoic acid
3-(4,4-dimethyl-heptanoyl)-(R)-4-methyl-(S)-5-phenyl-oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: 4,4-dimethyl-heptanoic acid With pivaloyl chloride; triethylamine In tetrahydrofuran for 1h; Stage #2: 4-methyl-5-phenyloxazolidin-2-one With lithium chloride In tetrahydrofuran for 18h; | 95% |
4-methyl-5-phenyloxazolidin-2-one
3-cyano-4,6-dimethyl-2-pyridinyl tosylate
4,6-dimethyl-2-((4R,5S)-4-methyl-2-oxo-5-phenyloxazolidin-3-yl)nicotinonitrile
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 100℃; for 16h; Inert atmosphere; | 95% |
4-(2-propenyloxy)butanoyl chloride
4-methyl-5-phenyloxazolidin-2-one
(4R)-methyl-(5S)-phenyl-3-(4-propenyloxy)butanoyloxazolidin-2-one
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran for 0.5h; cooling; | 94% |
4-methyl-5-phenyloxazolidin-2-one
trans-chrotonyl chloride
(4R,5S)-3-((E)-2-butenoyl)-4-methyl-5-phenyl-2-oxazolidinone
Conditions | Yield |
---|---|
With n-butyllithium 1.) THF, -78 deg C, 15 min; 2.) THF, -78 deg C, 30 min then 0 deg C, 15 min; | 93% |
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran at -40℃; Stage #2: trans-chrotonyl chloride In tetrahydrofuran at -50℃; Further stages.; |
4-methyl-5-phenyloxazolidin-2-one
(methylthio)acetyl chloride
(4R,5S)-3-(1'-oxo-2'-methylthioethyl)-4-methyl-5-phenyl-2-oxazolidinone
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran 1.) -78 deg C, 30 min, 2.) r.t., 30 min; | 93% |
77% |
4-methyl-5-phenyloxazolidin-2-one
acetic anhydride
(4R,5S)-3-acetyl-4-methyl-5-phenyl-2-oxazolidinone
Conditions | Yield |
---|---|
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With tetraethylammonium perchlorate In acetonitrile at 20℃; Electrochemical reaction; Stage #2: acetic anhydride With tetraethylammonium perchlorate In acetonitrile at 20℃; for 3h; Further stages.; | 93% |
4-methyl-5-phenyloxazolidin-2-one
4-triethylsilyloxy-4-methylpentanoic acid
(4R,5S)-(+)-4-methyl-5-phenyl-3-[4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone
Conditions | Yield |
---|---|
With dmap; pivaloyl chloride; triethylamine | 93% |
4-methyl-5-phenyloxazolidin-2-one
(S)-(-)-citronellic acid
(4R,5S)-3-(3,7-dimethyloct-6-enoyl)-4-methyl-5-phenyl-2-oxazolidinone
Conditions | Yield |
---|---|
With dmap; pivaloyl chloride; triethylamine In tetrahydrofuran for 24h; Heating; | 93% |
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