Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(4R,5S)-(+)-4-methyl-5-phenyl-2-oxazolidinone

Cas:77943-39-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% (4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE 77943-39-6 GMP Manufacturer

Cas:77943-39-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone

Cas:77943-39-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top quality CAS 77943-39-6 with high-quality service

Cas:77943-39-6

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE

Cas:77943-39-6

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE CAS:77943-39-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE CAS:77943-39-6

Cas:77943-39-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:77943-39-6

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Oxazolidinone,4-methyl-5-phenyl-, (4R,5S)-

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone CAS NO.77943-39-6

Cas:77943-39-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE

Cas:77943-39-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk production Chemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical manufacturing for overseas customers, in the field of API, pharmaceutical intermediates, chemical intermediates, fine

(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone

Cas:77943-39-6

Min.Order:1 Gram

FOB Price: $2.0 / 4.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bag, 1kg/bag or as per your request Application:Chiral auxiliaries Transportation:By exp

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE

Cas:77943-39-6

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone cas no. 77943-39-6 98%

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(4R,5S)-4-Methyl-5-phenyloxazolidinone

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec (4R,5S)-4-Methyl-5-phenyloxazolidin-2-one 25g

Cas:77943-39-6

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

(4R,5S)-4-Methyl-5-phenyloxazolidinone

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:off-white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as prima

(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

77943-39-6

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Other

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

(4R,5S)-4-methyl-5-phenyl-2-oxazolidinone

Cas:77943-39-6

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE

Cas:77943-39-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Changzhou Extraordinary Pharmatech co.,LTD

Changzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa

(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone

Cas:77943-39-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

hebei wego import and export trade co.,ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top quality (4R,5S)-(+)-4-methyl-5-phenyl-2-oxazolidinone 77943-39-6

Cas:77943-39-6

Min.Order:25 Kilogram

FOB Price: $10.0 / 20.0

Type:Trading Company

inquiry

Zhengzhou Kingorgchem Chemical Technology Co., Ltd.

1. Subsidiary of Institute of Chemistry, Henan Academy of Sciences, national research platform;2. About 30 years’ experience in this field since 1983;3. An experienced R&D team consisting of Doctors and Masters;4. Various types of analytical instrume

ISO 9001 National Research Platform CAS No. 77943-39-6

Cas:77943-39-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

(4R,5S)-3-((E)-(2R,3R)-3-Hydroxy-2,4-dimethyl-hept-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one
779353-80-9

(4R,5S)-3-((E)-(2R,3R)-3-Hydroxy-2,4-dimethyl-hept-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one

A

(E)-(2R,3R)-3-Hydroxy-2,4-dimethyl-hept-4-enoic acid methoxy-methyl-amide
541511-47-1

(E)-(2R,3R)-3-Hydroxy-2,4-dimethyl-hept-4-enoic acid methoxy-methyl-amide

B

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
Stage #1: N,O-dimethylhydroxylamine*hydrochloride With trimethylaluminum In tetrahydrofuran; toluene at 0 - 20℃;
Stage #2: (4R,5S)-3-((E)-(2R,3R)-3-Hydroxy-2,4-dimethyl-hept-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one In tetrahydrofuran; toluene at 0℃; for 1h;
A 100%
B 272 mg
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

mephenoxalone
70-07-5

mephenoxalone

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
With hydrogenchloride; AlMe3 In tetrahydrofuran; hexane; dichloromethane100%
With hydrogenchloride; AlMe3 In tetrahydrofuran; hexane; dichloromethane100%
With hydrogenchloride; AlMe3 In tetrahydrofuran; hexane; dichloromethane100%
carbon monoxide
201230-82-2

carbon monoxide

(1S,2R)-(+)-norphedrine
37577-28-9

(1S,2R)-(+)-norphedrine

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
With copper diacetate; air; palladium diacetate In toluene under 760 Torr; for 2h; Heating;99%
With sodium acetate; palladium diacetate In acetonitrile at 20℃; under 760 Torr; Electrolysis;86%
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

(2'R,3'S,4'S,4R,5S)-3-[3'-hydroxy-5'-(4"-methoxyphenyl)methoxy-2',4'-dimethylpentanoyl]-5-phenyl-4-methyl-2-oxazolidinone
132969-62-1

(2'R,3'S,4'S,4R,5S)-3-[3'-hydroxy-5'-(4"-methoxyphenyl)methoxy-2',4'-dimethylpentanoyl]-5-phenyl-4-methyl-2-oxazolidinone

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

(2R,3S,4S)-3-hydroxy-5-(4-methoxybenzyloxy)-2,4-dimethylpentanoic acid methoxymethylamide
252342-49-7

(2R,3S,4S)-3-hydroxy-5-(4-methoxybenzyloxy)-2,4-dimethylpentanoic acid methoxymethylamide

Conditions
ConditionsYield
Stage #1: N,O-dimethylhydroxylamine*hydrochloride With trimethylaluminum In tetrahydrofuran; hexane at 0 - 20℃; Metallation;
Stage #2: (2'R,3'S,4'S,4R,5S)-3-[3'-hydroxy-5'-(4"-methoxyphenyl)methoxy-2',4'-dimethylpentanoyl]-5-phenyl-4-methyl-2-oxazolidinone In tetrahydrofuran; hexane at -20℃; for 2.5h; Substitution; Further stages.;
A 80%
B 98%
carbon dioxide
124-38-9

carbon dioxide

(1S,2R)-(+)-norphedrine
37577-28-9

(1S,2R)-(+)-norphedrine

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
With triethylamine; acetyl chloride In acetonitrile at -40 - 25℃;97%
Stage #1: carbon dioxide; (1S,2R)-(+)-norphedrine With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 0.75h;
Stage #2: With tributylphosphine; di-tert-butyl-diazodicarboxylate In acetonitrile at 0℃; for 0.333333h; Mitsunobu reaction;
84%
With tetramethylphenylguanidine; chlorophosphoric acid diphenyl ester In acetonitrile at -40 - 20℃;82%
Stage #1: carbon dioxide; (1S,2R)-(+)-norphedrine With N(Et)4(1+)*(2-pyrrolidone-anion) In acetonitrile at 20℃; for 1h; Carboxylation;
Stage #2: With p-toluenesulfonyl chloride In acetonitrile at 20℃; Cyclization; Further stages.;
79%
(4R,5S)-(+)-(5-benzyloxy-2-fluoro-3-(E)-pentenoyl)-4-methyl-5-phenyl-2-oxazolidinone
179927-67-4

(4R,5S)-(+)-(5-benzyloxy-2-fluoro-3-(E)-pentenoyl)-4-methyl-5-phenyl-2-oxazolidinone

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

5-O-benzyl-2-deoxy-2-fluoro-L-γ-xylonic lactone
179927-65-2

5-O-benzyl-2-deoxy-2-fluoro-L-γ-xylonic lactone

C

5-O-benzyl-2-deoxy-2-fluoro-D-γ-xylonic lactone
179927-64-1

5-O-benzyl-2-deoxy-2-fluoro-D-γ-xylonic lactone

Conditions
ConditionsYield
With osmium(VIII) oxide; trimethylamine-N-oxide In water; acetone; tert-butyl alcohol at 20℃; for 2h; Oxidation; cyclization;A n/a
B 94%
C 86%
bis(phenyl) carbonate
102-09-0

bis(phenyl) carbonate

Acutrim
40626-29-7

Acutrim

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
With potassium carbonate at 110℃; for 6h;93%
Stage #1: bis(phenyl) carbonate; Acutrim With potassium carbonate at 100℃; for 6h;
Stage #2: In methanol for 0.5h; Heating;
C37H45NO6
954106-23-1

C37H45NO6

A

C27H36O5
954106-40-2

C27H36O5

B

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran at 20℃; for 2h;A 92%
B 79%
(4R,5S)-3-[(Z)-(R)-2-(tert-Butyl-diphenyl-silanyloxy)-dec-4-enoyl]-4-methyl-5-phenyl-oxazolidin-2-one
128891-59-8

(4R,5S)-3-[(Z)-(R)-2-(tert-Butyl-diphenyl-silanyloxy)-dec-4-enoyl]-4-methyl-5-phenyl-oxazolidin-2-one

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

(2R,4Z)-2(tert-Butyldiphenylsiloxy)-4-decen-1-ol
126617-76-3

(2R,4Z)-2(tert-Butyldiphenylsiloxy)-4-decen-1-ol

Conditions
ConditionsYield
With lithium borohydride; water In tetrahydrofuran; diethyl ether Product distribution; Ambient temperature; other reducing reagents; var. N-acyloxazolidinones;A n/a
B 90%
(4R,5S)-3-((R)-2-Benzyl-4-methyl-pent-3-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one
109687-75-4

(4R,5S)-3-((R)-2-Benzyl-4-methyl-pent-3-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

4-methyl-2(R)-(phenylmethyl)-3-penten-1-ol
109687-76-5

4-methyl-2(R)-(phenylmethyl)-3-penten-1-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at -78 - 0℃; for 1.5h;A 70%
B 90%
(2'S,4R,5S)-3-(2'-methyl-3'-phenylpropionyl)-4-methyl-5-phenyloxazolidin-2-one
80697-94-5

(2'S,4R,5S)-3-(2'-methyl-3'-phenylpropionyl)-4-methyl-5-phenyloxazolidin-2-one

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

(S)-2-methyl-3-phenylpropan-1-ol
7384-80-7, 77943-96-5, 78964-61-1, 22436-06-2

(S)-2-methyl-3-phenylpropan-1-ol

Conditions
ConditionsYield
With Cp*RuCl{(C6H5)2P-(CH2)2NH2-κ2-P,N}; potassium tert-butylate; hydrogen In isopropyl alcohol at 80℃; under 22502.3 Torr; for 20h; Autoclave; optical yield given as %ee;A 89%
B 90%
(4R,5S)-3-[(2S)-2-{(2S)-N-benzyloxycarbonylpyrrolidin-2-yl}propanoyl]-4-methyl-5-phenyl-2-oxazolidinone
321851-63-2

(4R,5S)-3-[(2S)-2-{(2S)-N-benzyloxycarbonylpyrrolidin-2-yl}propanoyl]-4-methyl-5-phenyl-2-oxazolidinone

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

(2S)-2-[(2S)-1-benzyloxycarbonylpyrrolidin-2-yl]-1-propanol
235084-93-2

(2S)-2-[(2S)-1-benzyloxycarbonylpyrrolidin-2-yl]-1-propanol

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran; water at 5℃; for 15h;A 97 mg
B 88%
(4R,5S,2'R,3'R,2"S)-3-[3'-(N-tert-butoxycarbonyl-2"-pyrrolidinyl)-3"-hydroxy-2'-methylpropanoyl]-4-methyl-5-phenyl-2-oxazolidinone
133645-51-9

(4R,5S,2'R,3'R,2"S)-3-[3'-(N-tert-butoxycarbonyl-2"-pyrrolidinyl)-3"-hydroxy-2'-methylpropanoyl]-4-methyl-5-phenyl-2-oxazolidinone

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

<1R-(1α,2β,7aα)>-Hexahydro-1-hydroxy-2-methyl-3-oxo-1H-pyrrolizine
133565-40-9

<1R-(1α,2β,7aα)>-Hexahydro-1-hydroxy-2-methyl-3-oxo-1H-pyrrolizine

Conditions
ConditionsYield
Stage #1: (4R,5S,2'R,3'R,2"S)-3-[3'-(N-tert-butoxycarbonyl-2"-pyrrolidinyl)-3"-hydroxy-2'-methylpropanoyl]-4-methyl-5-phenyl-2-oxazolidinone With trifluoroacetic acid at 20℃; for 0.333333h;
Stage #2: With potassium carbonate In ethanol; water at 0℃; for 1.5h;
A n/a
B 86%
(4R,5S)-3-<(2S)-1-oxo-2,4-dimethylpent-4-enyl>-4-methyl-5-phenyloxazolidin-2-one
80719-70-6

(4R,5S)-3-<(2S)-1-oxo-2,4-dimethylpent-4-enyl>-4-methyl-5-phenyloxazolidin-2-one

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

(S)-(-)-2,4-dimethylpent-4-en-1-ol
82507-47-9

(S)-(-)-2,4-dimethylpent-4-en-1-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether at 0℃; for 0.0833333h;A n/a
B 85%
(1S,2R)-(+)-norphedrine
37577-28-9

(1S,2R)-(+)-norphedrine

tetraethylammonium peroxycarbonate

tetraethylammonium peroxycarbonate

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
Stage #1: (1S,2R)-(+)-norphedrine; tetraethylammonium peroxycarbonate In acetonitrile at 20℃; for 2h; Acylation;
Stage #2: With p-toluenesulfonyl chloride In acetonitrile at 25℃; for 10h; Cyclization;
85%
carbon dioxide
124-38-9

carbon dioxide

(1S,2R)-(+)-norphedrine
37577-28-9

(1S,2R)-(+)-norphedrine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]-4-methylbenzenesulfonamide
58107-41-8, 58107-43-0, 108591-33-9, 131142-88-6, 143957-01-1, 136173-99-4

N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]-4-methylbenzenesulfonamide

Conditions
ConditionsYield
Stage #1: (1S,2R)-(+)-norphedrine In acetonitrile at 20℃; Electrolysis;
Stage #2: carbon dioxide for 1h;
Stage #3: p-toluenesulfonyl chloride at 20℃;
A 85%
B 14%
(1S,2R)-(+)-norphedrine
37577-28-9

(1S,2R)-(+)-norphedrine

Diethyl carbonate
105-58-8

Diethyl carbonate

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
With potassium carbonate In toluene at 110℃; Inert atmosphere; Large scale reaction;84.3%
With potassium carbonate at 150℃; for 2.5h;83%
MCM-41-TBD; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine for 24h; Heating;59%
(4R,5S)-3-<(2R)-1-oxo-2-<<(phenylmethyl)thio>methyl>-3-phenylpropyl>-4-methyl-5-phenyl-2-oxazolidinone
95798-32-6

(4R,5S)-3-<(2R)-1-oxo-2-<<(phenylmethyl)thio>methyl>-3-phenylpropyl>-4-methyl-5-phenyl-2-oxazolidinone

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

(2R)-2-<<(phenylmethyl)thio>methyl>-3-phenylpropanoic acid benzyl ester
95841-15-9

(2R)-2-<<(phenylmethyl)thio>methyl>-3-phenylpropanoic acid benzyl ester

Conditions
ConditionsYield
With lithium benzyloxide In tetrahydrofuran; hexane at 0℃; for 1.5h;A 75%
B 83%
C21H29NO3
954106-16-2

C21H29NO3

A

(2R,3S)-2,3,7-trimethyl-6-octen-1-ol
179913-85-0

(2R,3S)-2,3,7-trimethyl-6-octen-1-ol

B

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran; water at 20℃; for 5h;A 81%
B 83%
C17H23NO3

C17H23NO3

ethyl potassium malonate
6148-64-7

ethyl potassium malonate

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

ethyl (R)-5-methyl-3-oxo-octanoate
874208-98-7

ethyl (R)-5-methyl-3-oxo-octanoate

Conditions
ConditionsYield
Stage #1: C17H23NO3; ethyl potassium malonate With triethylamine; magnesium chloride In acetonitrile at 80℃; for 20h;
Stage #2: With hydrogenchloride In water at 10℃; Further stages.;
A n/a
B 83%
(4R,5S)-4-methyl-3-((S)-2-methylpent-4-enoyl)-5-phenyloxazolidin-2-one
80697-95-6

(4R,5S)-4-methyl-3-((S)-2-methylpent-4-enoyl)-5-phenyloxazolidin-2-one

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

(S)-(-)-2-methyl-4-penten-1-ol
5673-98-3, 63501-27-9, 88080-30-2, 63501-26-8

(S)-(-)-2-methyl-4-penten-1-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran -70 deg C, 40 min; -78 deg C, 1 h; -78 to -20 deg C, 2 h;A n/a
B 82%
(1S,2S)-2-amino-1-phenylpropanol
492-39-7

(1S,2S)-2-amino-1-phenylpropanol

Diethyl carbonate
105-58-8

Diethyl carbonate

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
With potassium carbonate In toluene at 130℃; Heating;80%
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

(2'R,3'S,4R,5S)-3-(3'-hydroxy-2'-methyl-4'-phenylbutanoyl)-4-methyl-5-phenyloxazolidin-2-one
134440-87-2

(2'R,3'S,4R,5S)-3-(3'-hydroxy-2'-methyl-4'-phenylbutanoyl)-4-methyl-5-phenyloxazolidin-2-one

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

(2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide
184354-37-8

(2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide

Conditions
ConditionsYield
With trimethylaluminum In dichloromethane at 0 - 4℃; for 3h;A n/a
B 78%
(4R,5S)-(+)-3-[(2R)-2-isopropyl-5-methyl-1-oxohex-5-en-1-yl]-4-methyl-5-phenyl-2-oxazolidinone
317801-57-3

(4R,5S)-(+)-3-[(2R)-2-isopropyl-5-methyl-1-oxohex-5-en-1-yl]-4-methyl-5-phenyl-2-oxazolidinone

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

(R)-(+)-2-isopropyl-5-methylhex-5-ene-1-carboxylic acid
317801-61-9

(R)-(+)-2-isopropyl-5-methylhex-5-ene-1-carboxylic acid

Conditions
ConditionsYield
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran; water at 20℃; for 16h; cleavage;A n/a
B 75%
carbon dioxide
124-38-9

carbon dioxide

(1S,2R)-(+)-norphedrine
37577-28-9

(1S,2R)-(+)-norphedrine

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

diethyl ((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)phosphoramidate

diethyl ((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)phosphoramidate

Conditions
ConditionsYield
With tetramethylphenylguanidine In acetonitrile at -40 - 20℃;A 55%
B n/a
With N,N,N',N'-tetramethyl-N-phenylguanidine In acetonitrile at -40 - 25℃;A 55%
B 22%
benzyl N-(1H-benzotriazol-1-ylmethyl)carbamate
125453-11-4

benzyl N-(1H-benzotriazol-1-ylmethyl)carbamate

(4R,5S)-4-methyl-5-phenyl-3-phenylacetyl-oxazolidin-2-one
96930-16-4

(4R,5S)-4-methyl-5-phenyl-3-phenylacetyl-oxazolidin-2-one

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

[(S)-3-((4R,5S)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-2-phenyl-propyl]-carbamic acid benzyl ester

[(S)-3-((4R,5S)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-2-phenyl-propyl]-carbamic acid benzyl ester

C

[(R)-3-((4R,5S)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-2-phenyl-propyl]-carbamic acid benzyl ester

[(R)-3-((4R,5S)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-2-phenyl-propyl]-carbamic acid benzyl ester

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuranA 20%
B 54%
C 2%
(4R,5S)-4-methyl-5-phenyl-3-phenylacetyl-oxazolidin-2-one
96930-16-4

(4R,5S)-4-methyl-5-phenyl-3-phenylacetyl-oxazolidin-2-one

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

[(S)-3-((4R,5S)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-2-phenyl-propyl]-carbamic acid benzyl ester

[(S)-3-((4R,5S)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-2-phenyl-propyl]-carbamic acid benzyl ester

C

[(R)-3-((4R,5S)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-2-phenyl-propyl]-carbamic acid benzyl ester

[(R)-3-((4R,5S)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-2-phenyl-propyl]-carbamic acid benzyl ester

Conditions
ConditionsYield
With benzyl N-(1H-benzotriazol-1-ylmethyl)carbamate; lithium diisopropyl amide In tetrahydrofuranA 20%
B 54%
C 2%
Acetic acid (1S,2R)-1-ethyl-2-methyl-3-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl ester
142719-20-8

Acetic acid (1S,2R)-1-ethyl-2-methyl-3-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl ester

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

(2S,3R,6R,7S)-7-Ethyl-3,6-dimethyl-2-phenyl-1,8-dioxa-4-aza-cycloundecane-5,9,11-trione
142719-21-9

(2S,3R,6R,7S)-7-Ethyl-3,6-dimethyl-2-phenyl-1,8-dioxa-4-aza-cycloundecane-5,9,11-trione

C

(5R,6S)-6-Ethyl-4-hydroxy-5-methyl-5,6-dihydro-pyran-2-one
142761-27-1

(5R,6S)-6-Ethyl-4-hydroxy-5-methyl-5,6-dihydro-pyran-2-one

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 2h;A 45%
B 43%
C 37%
ammonium thiocyanate
1147550-11-5

ammonium thiocyanate

Acutrim
40626-29-7

Acutrim

A

4-methyl-5-phenyl-thiazolidin-2-one

4-methyl-5-phenyl-thiazolidin-2-one

B

(4R,5R)-(+)-4-methyl-5-phenyl-thiazolidin-2-one

(4R,5R)-(+)-4-methyl-5-phenyl-thiazolidin-2-one

C

(4R,5S)-4-Methyl-5-phenyl-thiazolidine-2-thione

(4R,5S)-4-Methyl-5-phenyl-thiazolidine-2-thione

D

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
at 180 - 200℃; for 4h; Further byproducts given;A n/a
B 40%
C n/a
D n/a
(4R,5S)-(+)-3-[(2R)-2-isopropyl-5-methyl-1-oxohex-5-en-1-yl]-4-methyl-5-phenyl-2-oxazolidinone
317801-57-3

(4R,5S)-(+)-3-[(2R)-2-isopropyl-5-methyl-1-oxohex-5-en-1-yl]-4-methyl-5-phenyl-2-oxazolidinone

A

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

B

(R)-(+)-2-isopropyl-5-methylhex-5-en-1-ol
264258-71-1

(R)-(+)-2-isopropyl-5-methylhex-5-en-1-ol

C

(2R)-N-2-((1S,2R)-2-methyl-1-phenylethoxy)-5-methyl-2-(1-methylethyl)-5-hexenyl amide

(2R)-N-2-((1S,2R)-2-methyl-1-phenylethoxy)-5-methyl-2-(1-methylethyl)-5-hexenyl amide

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at -78 - 0℃; Reduction;A 25%
B 33%
C 39%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

(R)-6-cyclohexyl-4-methylhexanoic acid
849488-05-7

(R)-6-cyclohexyl-4-methylhexanoic acid

(4R,5S)-3-((R)-6-cyclohexyl-4-methyl-hexanoyl)-4-methyl-5-phenyl-oxazolidin-2-one

(4R,5S)-3-((R)-6-cyclohexyl-4-methyl-hexanoyl)-4-methyl-5-phenyl-oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: (R)-6-cyclohexyl-4-methylhexanoic acid With pivaloyl chloride; triethylamine In tetrahydrofuran at 0℃; for 1h;
Stage #2: 4-methyl-5-phenyloxazolidin-2-one With lithium chloride In tetrahydrofuran at 0 - 20℃;
100%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

pent-4-enoyl chloride
39716-58-0

pent-4-enoyl chloride

(4R,5S)-4-methyl-3-pent-4-enoyl-5-phenyloxazolidin-2-one
96930-18-6

(4R,5S)-4-methyl-3-pent-4-enoyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; Inert atmosphere;
Stage #2: pent-4-enoyl chloride In tetrahydrofuran; hexane at -78 - 20℃; for 2h; Inert atmosphere;
99%
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; Inert atmosphere;
Stage #2: pent-4-enoyl chloride In tetrahydrofuran; hexane at 0 - 20℃; for 0.5h; Inert atmosphere;
99%
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.583333h;
Stage #2: pent-4-enoyl chloride In tetrahydrofuran; hexane at -78 - -20℃; Further stages.;
86%
With n-butyllithium 1.) THF, -78 deg C, 1 h, 2.) 20 deg C, 24 h; Yield given. Multistep reaction;
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

(Z)-Dec-4-enoyl chloride
57679-86-4, 70173-09-0

(Z)-Dec-4-enoyl chloride

(4R,5S)-3-((Z)-Dec-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one
118267-98-4

(4R,5S)-3-((Z)-Dec-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran at -78 - -10℃;99%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

acetyl chloride
75-36-5

acetyl chloride

(4R,5S)-3-acetyl-4-methyl-5-phenyl-2-oxazolidinone
96093-41-3

(4R,5S)-3-acetyl-4-methyl-5-phenyl-2-oxazolidinone

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran at 0℃;99%
With n-butyllithium In tetrahydrofuran 1.) -78 deg C, 20 min, 2.) r.t., 20 min;90%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

butyryl chloride
141-75-3

butyryl chloride

(4R,5S)-(+)-4-methyl-3-(1'-oxobutyl)-5-phenyloxazolidin-2-one
80697-91-2

(4R,5S)-(+)-4-methyl-3-(1'-oxobutyl)-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane
Stage #2: butyryl chloride In tetrahydrofuran; hexane at 20℃; for 2h;
99%
With n-butyllithium In tetrahydrofuran at -78℃;91%
With n-butyllithium 1.) THF, -78 deg C, 1 h, 2.) 20 deg C, 24 h; Yield given. Multistep reaction;
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

isopentanoyl chloride
108-12-3

isopentanoyl chloride

(4R,5S)-(+)-3-[3-methyl-1-oxobut-1-yl]-4-methyl-5-phenyl-2-oxazolidinone
107599-99-5

(4R,5S)-(+)-3-[3-methyl-1-oxobut-1-yl]-4-methyl-5-phenyl-2-oxazolidinone

Conditions
ConditionsYield
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane
Stage #2: isopentanoyl chloride In tetrahydrofuran; hexane at 20℃; for 2h;
99%
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: isopentanoyl chloride In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;
99%
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h;
Stage #2: isopentanoyl chloride In tetrahydrofuran; hexachloroethane at -78℃; for 0.5h;
39%
With n-butyllithium 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, from -78 deg C to RT, 30 min; Yield given. Multistep reaction;
With n-butyllithium In tetrahydrofuran at -78 - 20℃;
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

1-iodo-2,2-dimethyl-1,2-propadiene
31819-97-3

1-iodo-2,2-dimethyl-1,2-propadiene

(4R,5S)-4-Methyl-3-(3-methyl-buta-1,2-dienyl)-5-phenyl-oxazolidin-2-one

(4R,5S)-4-Methyl-3-(3-methyl-buta-1,2-dienyl)-5-phenyl-oxazolidin-2-one

Conditions
ConditionsYield
With potassium phosphate; copper(I) thiophene-2-carboxylate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane In toluene at 85℃; for 5h;99%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

cyclopentanepropanoyl chloride
104-97-2

cyclopentanepropanoyl chloride

(4R,5S)-3-(3-cyclopentylpropanoyl)-4-methyl-5-phenyloxazolidin-2-one
944385-34-6

(4R,5S)-3-(3-cyclopentylpropanoyl)-4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 1.5h;99%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

propionyl chloride
79-03-8

propionyl chloride

(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one
77877-20-4

(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃;98%
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane
Stage #2: propionyl chloride In tetrahydrofuran; hexane at 20℃; for 2h;
98%
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: propionyl chloride In tetrahydrofuran; hexane at -78 - -50℃; for 2h;
98%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

isobutyryl chloride
79-30-1

isobutyryl chloride

(4R,5S)-3-isobutyryl-4-methyl-5-phenyloxazolidin-2-one

(4R,5S)-3-isobutyryl-4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran at -78℃; for 0.75h; deprotonation;
Stage #2: isobutyryl chloride In tetrahydrofuran at -78℃; for 2h; Acylation;
98%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

Hexanoyl chloride
142-61-0

Hexanoyl chloride

(4R,5S)-3-hexanoyl-4-methyl-5-phenyloxazolidin-2-one
131636-15-2

(4R,5S)-3-hexanoyl-4-methyl-5-phenyloxazolidin-2-one

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran at -78℃;97%
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h;
Stage #2: Hexanoyl chloride In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #3: With sodium hydroxide In tetrahydrofuran; hexane; water
72%
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane; ethyl acetate at -78℃; for 0.166667h;
Stage #2: Hexanoyl chloride In tetrahydrofuran; hexane at -78 - 20℃;
72%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

propionic acid anhydride
123-62-6

propionic acid anhydride

(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one
77877-20-4

(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one

Conditions
ConditionsYield
With electrogenerated base from 2-pyrrolidone; tetraethylammonium perchlorate In acetonitrile at 20℃;97%
With dmap; triethylamine In tetrahydrofuran for 1h; Ambient temperature;73%
With 2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; N-ethyl-N,N-diisopropylamine In chloroform-d1 at 50℃; for 3h; Inert atmosphere;
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

4-methylvaleroyl chloride
38136-29-7

4-methylvaleroyl chloride

(4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyl-oxazolidin-2-one
134458-52-9

(4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyl-oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78 - 0℃; for 0.25h; Inert atmosphere;
Stage #2: 4-methylvaleroyl chloride In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
97%
With n-butyllithium; sodium hydrogencarbonate In tetrahydrofuran; hexanes at -78 - 0℃; for 1.41667h; Argon atmosphere;82%
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h;
Stage #2: 4-methylvaleroyl chloride In tetrahydrofuran; hexane at -78℃; for 0.5h;
38%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

3-(4,4-dimethyl-heptanoyl)-(R)-4-methyl-(S)-5-phenyl-oxazolidin-2-one
610300-44-2

3-(4,4-dimethyl-heptanoyl)-(R)-4-methyl-(S)-5-phenyl-oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: 4,4-dimethyl-heptanoic acid With pivaloyl chloride; triethylamine In tetrahydrofuran at 0℃; for 1h;
Stage #2: 4-methyl-5-phenyloxazolidin-2-one With lithium chloride In tetrahydrofuran for 18h;
95%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

4,4-dimethyl-heptanoic acid
50902-80-2

4,4-dimethyl-heptanoic acid

3-(4,4-dimethyl-heptanoyl)-(R)-4-methyl-(S)-5-phenyl-oxazolidin-2-one
610300-44-2

3-(4,4-dimethyl-heptanoyl)-(R)-4-methyl-(S)-5-phenyl-oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: 4,4-dimethyl-heptanoic acid With pivaloyl chloride; triethylamine In tetrahydrofuran for 1h;
Stage #2: 4-methyl-5-phenyloxazolidin-2-one With lithium chloride In tetrahydrofuran for 18h;
95%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

3-cyano-4,6-dimethyl-2-pyridinyl tosylate
1174281-26-5

3-cyano-4,6-dimethyl-2-pyridinyl tosylate

4,6-dimethyl-2-((4R,5S)-4-methyl-2-oxo-5-phenyloxazolidin-3-yl)nicotinonitrile
1233503-31-5

4,6-dimethyl-2-((4R,5S)-4-methyl-2-oxo-5-phenyloxazolidin-3-yl)nicotinonitrile

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 100℃; for 16h; Inert atmosphere;95%
4-(2-propenyloxy)butanoyl chloride
922724-77-4

4-(2-propenyloxy)butanoyl chloride

4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

(4R)-methyl-(5S)-phenyl-3-(4-propenyloxy)butanoyloxazolidin-2-one
922724-76-3

(4R)-methyl-(5S)-phenyl-3-(4-propenyloxy)butanoyloxazolidin-2-one

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran for 0.5h; cooling;94%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

trans-chrotonyl chloride
625-35-4, 3488-22-0, 10487-71-5

trans-chrotonyl chloride

(4R,5S)-3-((E)-2-butenoyl)-4-methyl-5-phenyl-2-oxazolidinone
90719-31-6

(4R,5S)-3-((E)-2-butenoyl)-4-methyl-5-phenyl-2-oxazolidinone

Conditions
ConditionsYield
With n-butyllithium 1.) THF, -78 deg C, 15 min; 2.) THF, -78 deg C, 30 min then 0 deg C, 15 min;93%
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With n-butyllithium In tetrahydrofuran at -40℃;
Stage #2: trans-chrotonyl chloride In tetrahydrofuran at -50℃; Further stages.;
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

(methylthio)acetyl chloride
35928-65-5

(methylthio)acetyl chloride

(4R,5S)-3-(1'-oxo-2'-methylthioethyl)-4-methyl-5-phenyl-2-oxazolidinone
116857-38-6

(4R,5S)-3-(1'-oxo-2'-methylthioethyl)-4-methyl-5-phenyl-2-oxazolidinone

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran 1.) -78 deg C, 30 min, 2.) r.t., 30 min;93%
77%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

acetic anhydride
108-24-7

acetic anhydride

(4R,5S)-3-acetyl-4-methyl-5-phenyl-2-oxazolidinone
96093-41-3

(4R,5S)-3-acetyl-4-methyl-5-phenyl-2-oxazolidinone

Conditions
ConditionsYield
Stage #1: 4-methyl-5-phenyloxazolidin-2-one With tetraethylammonium perchlorate In acetonitrile at 20℃; Electrochemical reaction;
Stage #2: acetic anhydride With tetraethylammonium perchlorate In acetonitrile at 20℃; for 3h; Further stages.;
93%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

4-triethylsilyloxy-4-methylpentanoic acid
383397-31-7

4-triethylsilyloxy-4-methylpentanoic acid

(4R,5S)-(+)-4-methyl-5-phenyl-3-[4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone
383397-33-9

(4R,5S)-(+)-4-methyl-5-phenyl-3-[4-triethylsilyloxy-4-methylpentanoyl]-2-oxazolidinone

Conditions
ConditionsYield
With dmap; pivaloyl chloride; triethylamine93%
4-methyl-5-phenyloxazolidin-2-one
77943-39-6

4-methyl-5-phenyloxazolidin-2-one

(S)-(-)-citronellic acid
2111-53-7

(S)-(-)-citronellic acid

(4R,5S)-3-(3,7-dimethyloct-6-enoyl)-4-methyl-5-phenyl-2-oxazolidinone
954106-37-7

(4R,5S)-3-(3,7-dimethyloct-6-enoyl)-4-methyl-5-phenyl-2-oxazolidinone

Conditions
ConditionsYield
With dmap; pivaloyl chloride; triethylamine In tetrahydrofuran for 24h; Heating;93%
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View