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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Norbuprenorphine

Cas:78715-23-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFU-CHEM NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Henan Tianfu Chemical Co., Ltd.

Product Name: NORBUPRENORPHINE Synonyms: NORBUPRENORPHINE;(aS,5a,7a)-a-(1,1-Dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-a-methyl-6,14-ethenomorphinan-7-methanol;N-De(cyclopropylmethyl)buprenorphine;N-Dealkylbuprenorphine;N-Des

TIANFU-CHEM NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFU-CHEM NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFU-CHEM NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFU-CHEM NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFU-CHEM NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Qingdao Beluga Import and Export Co., LTD

We are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for

TIANFU-CHEM NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

TIANFU-CHEM NORBUPRENORPHINE Application:TIANFU-CHEM NORBUPRENORPHINE

TIANFU-CHEM NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

78715-23-8

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

TIANFU-CHEM NORBUPRENORPHINEAppearance:white powder Storage:room temperature Package:200KG Application:Industrial Grade Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to airport) or by sea LCL/FCL fo

TIANFU-CHEM NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

Stable supply of goods and provision of high-quality services Application:As raw materials in the field of medicine and biology

TIANFU-CHEM NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

Amadis Chemical offer CAS#78715-23-8;CAT#A852802

Cas:78715-23-8

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Changzhou Extraordinary Pharmatech co.,LTD

Changzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa

Norbuprenorphine

Cas:78715-23-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Fine Chemicals Co., Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & CommercialHenan Fine Chemicals Co., LTD. is a diversified technology - oriented integrated company, which mainly concentrates on fine chemicals. Our company is committed to becom

Simson Pharma Limited

The system can just identify the products information in first sheet, it is not be permitted to add or edit new sheet by userself.Our products are required in MG to Gram only. · Pharmaceutical Reference Standards· Traceable workin

Norbuprenorphine

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Nanjing Raymon Biotech Co., Ltd.

6,14-Ethenomorphinan-7-methanol,a-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-a-methyl-, (aS,5a,7a)- Storage:keep in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/pharma interme

Finetech Industry Limited

FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the Norbuprenorphine, CAS:78715-23-8 with the most competitive price and the best quality

Norbuprenorphine

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Taizhou volsen chemical Co., Ltd

We are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for

TIANFU-CHEM NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Minshang Biotechnology Co., Ltd

TIANFU-CHEM NORBUPRENORPHINE Application:Industrial Grade

78715-23-8

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fenjun Chemical Co Ltd.

TIANFU-CHEM NORBUPRENORPHINE Application:TIANFU-CHEM NORBUPRENORPHINE

TIANFU-CHEM NORBUPRENORPHINE

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Ruishun Trade Co.,Ltd

Supply top quality products with a reasonable price Application:api

78715-23-8

Cas:78715-23-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

N-cyano-7α-(1--hydroxy-1,2,2-trimethylpropyl)-6,14-endo-ethano-6,7,8,14-tetrahydronorthebaine

N-cyano-7α-(1--hydroxy-1,2,2-trimethylpropyl)-6,14-endo-ethano-6,7,8,14-tetrahydronorthebaine

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
With water; potassium hydroxide In diethylene glycol at 185℃; Product distribution / selectivity; Inert atmosphere;97.19%
With potassium hydroxide In diethylene glycol at 100 - 200℃; for 1h; Inert atmosphere;3.2 g
(S)-2-((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol
22151-78-6, 136232-87-6, 16614-59-8

(S)-2-((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Stage #1: (S)-2-((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol With water; potassium hydroxide In diethylene glycol at 185℃; for 5.25h;
Stage #2: With sulfuric acid In water; diethylene glycol at 90℃; pH=8.6;
80%
[5α,7α]-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-α,17-dimethyl-6,14-ethenomorphinan-7-methanol
22152-80-3, 85080-82-6, 98301-16-7, 98301-77-0, 136232-78-5, 136314-59-5, 16196-70-6

[5α,7α]-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-α,17-dimethyl-6,14-ethenomorphinan-7-methanol

A

(S)-2-((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol
22151-78-6, 136232-87-6, 16614-59-8

(S)-2-((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol

B

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
With D-Galactose; Cunninghamella echinulata NRRL 1384 at 28 - 32℃; for 168h; Product distribution / selectivity; Microbiological reaction; Basal fermentation medium;A 55%
B 16.4%
With Maltose; Cunninghamella echinulata NRRL 1384 at 28 - 32℃; for 168h; Product distribution / selectivity; Microbiological reaction; Basal fermentation medium;A 47.2%
B 13.2%
With Sucrose; Cunninghamella echinulata NRRL 1384 at 28 - 32℃; for 168h; Product distribution / selectivity; Microbiological reaction; Basal fermentation medium;A 42.4%
B 12.1%
1-[(5α,7α)-3-methoxy-4,5-epoxy-18,19-dihydro-7-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-6,14-ethenomorphinan-17-yl]ethanone
1352741-85-5

1-[(5α,7α)-3-methoxy-4,5-epoxy-18,19-dihydro-7-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-6,14-ethenomorphinan-17-yl]ethanone

A

[5α,7α]-17-acetyl-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanolamide
1352741-86-6

[5α,7α]-17-acetyl-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanolamide

B

(S)-2-((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol
22151-78-6, 136232-87-6, 16614-59-8

(S)-2-((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol

C

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
With potassium hydroxide In diethylene glycol at 170 - 180℃; for 7h; Inert atmosphere;A 42%
B 10%
C 35%
1-[(5α,7α)-3-methoxy-4,5-epoxy-18,19-dihydro-7-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-6,14-ethenomorphinan-17-yl]ethanone
1352741-85-5

1-[(5α,7α)-3-methoxy-4,5-epoxy-18,19-dihydro-7-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-6,14-ethenomorphinan-17-yl]ethanone

A

[5α,7α]-17-acetyl-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanolamide
1352741-86-6

[5α,7α]-17-acetyl-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanolamide

B

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
With potassium hydroxide In diethylene glycol at 170 - 180℃; for 7h; Inert atmosphere;A 37%
B 40%
C32H41NO4

C32H41NO4

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In methanol at 60℃; under 2068.65 Torr; for 2.5h; Product distribution / selectivity;
1-[(5α,7α)-3-methoxy-4,5-epoxy-18,19-dihydro-7-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-6,14-ethenomorphinan-17-yl]ethanone
1352741-85-5

1-[(5α,7α)-3-methoxy-4,5-epoxy-18,19-dihydro-7-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-6,14-ethenomorphinan-17-yl]ethanone

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide / diethylene glycol / 7 h / 170 - 180 °C / Inert atmosphere
2: potassium hydroxide / diethylene glycol / 7 h / 170 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide / diethylene glycol / 7 h / 170 - 180 °C / Inert atmosphere
2: potassium hydroxide / diethylene glycol / 7 h / 170 °C
View Scheme
[5α,7α]-17-acetyl-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanolamide
1352741-86-6

[5α,7α]-17-acetyl-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanolamide

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
With potassium hydroxide In diethylene glycol at 170℃; for 7h;
With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.666667h; Reagent/catalyst; Inert atmosphere;
[5α,7α]-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-α,17-dimethyl-6,14-ethenomorphinan-7-methanol
22152-80-3, 85080-82-6, 98301-16-7, 98301-77-0, 136232-78-5, 136314-59-5, 16196-70-6

[5α,7α]-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-α,17-dimethyl-6,14-ethenomorphinan-7-methanol

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper diacetate; palladium diacetate / 1,4-dioxane / 23 h / 80 °C
2: potassium hydroxide / diethylene glycol / 7 h / 170 - 180 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: copper diacetate; palladium diacetate / 1,4-dioxane / 23 h / 80 °C
2: potassium hydroxide / diethylene glycol / 7 h / 170 - 180 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: copper diacetate; palladium diacetate / 1,4-dioxane / 23 h / 80 °C
2: potassium hydroxide / diethylene glycol / 7 h / 170 - 180 °C / Inert atmosphere
3: potassium hydroxide / diethylene glycol / 7 h / 170 °C
View Scheme
Multi-step reaction with 3 steps
1: copper diacetate; palladium diacetate / 1,4-dioxane / 23 h / 80 °C
2: potassium hydroxide / diethylene glycol / 7 h / 170 - 180 °C / Inert atmosphere
3: potassium hydroxide / diethylene glycol / 7 h / 170 °C
View Scheme
Multi-step reaction with 2 steps
1: chloroform / 12 h / Reflux
2: potassium hydroxide / diethylene glycol / 1 h / 100 - 200 °C / Inert atmosphere
View Scheme
N-nororipavine
7168-66-3

N-nororipavine

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere
2: toluene / 80 h / 20 - 80 °C / Inert atmosphere
3: tetrahydrofuran; toluene / 3 h / 50 - 60 °C / Inert atmosphere
4: lithium aluminium tetrahydride / tetrahydrofuran / 21 h / 20 - 70 °C / Inert atmosphere
5: hydrogen; palladium 10% on activated carbon; acetic acid / isopropyl alcohol; water; methanol / 144 h / 60 °C / 760.05 Torr
View Scheme
(12bS)-3-benzoyl-7-methoxy-2 3,4,7a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl benzoate

(12bS)-3-benzoyl-7-methoxy-2 3,4,7a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl benzoate

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: toluene / 80 h / 20 - 80 °C / Inert atmosphere
2: tetrahydrofuran; toluene / 3 h / 50 - 60 °C / Inert atmosphere
3: lithium aluminium tetrahydride / tetrahydrofuran / 21 h / 20 - 70 °C / Inert atmosphere
4: hydrogen; palladium 10% on activated carbon; acetic acid / isopropyl alcohol; water; methanol / 144 h / 60 °C / 760.05 Torr
View Scheme
(4R,4aR,7R,7aR,12bS,14S)-14-acetyl-3-benzoyl-7-methoxy-1,2,3,4,7,7a-hexahydro-7,4a-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl benzoate

(4R,4aR,7R,7aR,12bS,14S)-14-acetyl-3-benzoyl-7-methoxy-1,2,3,4,7,7a-hexahydro-7,4a-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl benzoate

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran; toluene / 3 h / 50 - 60 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 21 h / 20 - 70 °C / Inert atmosphere
3: hydrogen; palladium 10% on activated carbon; acetic acid / isopropyl alcohol; water; methanol / 144 h / 60 °C / 760.05 Torr
View Scheme
((4R,4aR,7R,7aR,12bS,14R)-9-hydroxy-14-(2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,7,7a-tetrahydro-7,4a-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-3(4H)-yl)(phenyl)methanone

((4R,4aR,7R,7aR,12bS,14R)-9-hydroxy-14-(2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,7,7a-tetrahydro-7,4a-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-3(4H)-yl)(phenyl)methanone

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 21 h / 20 - 70 °C / Inert atmosphere
2: hydrogen; palladium 10% on activated carbon; acetic acid / isopropyl alcohol; water; methanol / 144 h / 60 °C / 760.05 Torr
View Scheme
(4R,4aR,7R,7aR,12bS,14R)-3-benzyl-14-(2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,7,7a-hexahydro-7,4a-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol

(4R,4aR,7R,7aR,12bS,14R)-3-benzyl-14-(2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,7,7a-hexahydro-7,4a-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; acetic acid In methanol; water; isopropyl alcohol at 60℃; under 760.051 Torr; for 144h;
C25H29NO6

C25H29NO6

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene / 3 h / 60 °C / Inert atmosphere
2: Schwartz's reagent / tetrahydrofuran / 0.67 h / 20 °C / Inert atmosphere
View Scheme
C25H27NO6

C25H27NO6

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; acetic acid / isopropyl alcohol; water / 72 h / 80 °C / 760.05 Torr
2: toluene / 3 h / 60 °C / Inert atmosphere
3: Schwartz's reagent / tetrahydrofuran / 0.67 h / 20 °C / Inert atmosphere
View Scheme
C27H35NO5

C27H35NO5

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen; palladium 10% on activated carbon; acetic acid / isopropyl alcohol; water / 72 h / 80 °C / 760.05 Torr
2: Schwartz's reagent / tetrahydrofuran / 0.67 h / 20 °C / Inert atmosphere
View Scheme
7-acetyl-6,14-endo-ethano-6,7,8,14-tetrahydrothebaine
16196-82-0

7-acetyl-6,14-endo-ethano-6,7,8,14-tetrahydrothebaine

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium / diethyl ether; benzene
1.2: 6 h / Reflux
2.1: chloroform / 12 h / Reflux
3.1: potassium hydroxide / diethylene glycol / 1 h / 100 - 200 °C / Inert atmosphere
View Scheme
thevinone
15358-22-2

thevinone

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol / 50 - 60 °C / 30003 - 37503.8 Torr
2.1: magnesium / diethyl ether; benzene
2.2: 6 h / Reflux
3.1: chloroform / 12 h / Reflux
4.1: potassium hydroxide / diethylene glycol / 1 h / 100 - 200 °C / Inert atmosphere
View Scheme
thebaine
115-37-7

thebaine

norbuprenorphine
78715-23-8

norbuprenorphine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 1 h / Reflux
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 50 - 60 °C / 30003 - 37503.8 Torr
3.1: magnesium / diethyl ether; benzene
3.2: 6 h / Reflux
4.1: chloroform / 12 h / Reflux
5.1: potassium hydroxide / diethylene glycol / 1 h / 100 - 200 °C / Inert atmosphere
View Scheme
allyl bromide
106-95-6

allyl bromide

norbuprenorphine
78715-23-8

norbuprenorphine

17-allyl-7α-[(2S)-3,3-dimethyl-2-hydroxybutan-2-yl]-4,5α-epoxy-3-hydroxy-6-methoxy-6α,14α-ethanomorphinan
162333-28-0

17-allyl-7α-[(2S)-3,3-dimethyl-2-hydroxybutan-2-yl]-4,5α-epoxy-3-hydroxy-6-methoxy-6α,14α-ethanomorphinan

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl acetamide at 60℃; for 5h;97.2%
cyclopropylcarbinyl bromide
7051-34-5

cyclopropylcarbinyl bromide

norbuprenorphine
78715-23-8

norbuprenorphine

Buprenorphine
52485-79-7

Buprenorphine

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1-methyl-pyrrolidin-2-one at 80℃; for 18h; Inert atmosphere;86%
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 80 - 100℃; for 4h;
With sodium hydrogencarbonate; potassium iodide In N,N-dimethyl-formamide at 85℃; for 5.5h; Product distribution / selectivity;
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 62 - 85℃; Product distribution / selectivity;
Cyclopropanecarboxaldehyde
1489-69-6

Cyclopropanecarboxaldehyde

norbuprenorphine
78715-23-8

norbuprenorphine

Buprenorphine
52485-79-7

Buprenorphine

Conditions
ConditionsYield
With formic acid; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; triethylamine In acetonitrile at 20 - 60℃; for 1h; Inert atmosphere;78%
norbuprenorphine
78715-23-8

norbuprenorphine

methyl iodide
74-88-4

methyl iodide

17-allyl-7α-[(2S)-3,3-dimethyl-2-hydroxybutan-2-yl]-4,5α-epoxy-3-hydroxy-6-methoxy-6α,14α-ethanomorphinan

17-allyl-7α-[(2S)-3,3-dimethyl-2-hydroxybutan-2-yl]-4,5α-epoxy-3-hydroxy-6-methoxy-6α,14α-ethanomorphinan

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl acetamide at 20℃; for 24h;74%
Cyclopropanecarboxaldehyde
1489-69-6

Cyclopropanecarboxaldehyde

norbuprenorphine
78715-23-8

norbuprenorphine

buprenorphine hydrochloride

buprenorphine hydrochloride

Conditions
ConditionsYield
Stage #1: Cyclopropanecarboxaldehyde; norbuprenorphine With hydrogen; platinum on activated charcoal In 1-methyl-pyrrolidin-2-one; methanol at 50℃; under 2068.65 Torr; for 2h;
Stage #2: With hydrogenchloride In ethanol; water
norbuprenorphine
78715-23-8

norbuprenorphine

buprenorphine hydrochloride

buprenorphine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; triethylamine; formic acid / acetonitrile / 1 h / 20 - 60 °C / Inert atmosphere
2: hydrogenchloride / ethanol; water / Heating
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 13 h / 20 °C / Cooling with ice
2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3: hydrogenchloride / ethanol; diethyl ether / 20 °C / pH 2
View Scheme
norbuprenorphine
78715-23-8

norbuprenorphine

C29H39(2)H2NO4*ClH

C29H39(2)H2NO4*ClH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 13 h / 20 °C / Cooling with ice
2.1: lithium aluminium deuteride / tetrahydrofuran / 20 °C
2.2: pH 2
View Scheme
norbuprenorphine
78715-23-8

norbuprenorphine

C30H40(2)H3NO4*ClH

C30H40(2)H3NO4*ClH

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 13 h / 20 °C / Cooling with ice
2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3: potassium carbonate / N,N-dimethyl-formamide / 15 h / 50 °C
View Scheme
norbuprenorphine
78715-23-8

norbuprenorphine

Buprenorphine
52485-79-7

Buprenorphine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 13 h / 20 °C / Cooling with ice
2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
View Scheme
norbuprenorphine
78715-23-8

norbuprenorphine

C29H39(2)H2NO4*ClH

C29H39(2)H2NO4*ClH

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 13 h / 20 °C / Cooling with ice
2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3: bromine / dichloromethane / 1 h / 30 °C / Cooling with ice
4: deuterium; triethylamine; palladium 10% on activated carbon / tetrahydrofuran / 24 h / 20 °C
View Scheme
norbuprenorphine
78715-23-8

norbuprenorphine

(2S)-2-[(5R,6R,7R,14S)-1,2-dibromo-N-cyclopropylmethyl-4,5-epoxy-6,14-ethylene-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylbutyl-2-alcohol

(2S)-2-[(5R,6R,7R,14S)-1,2-dibromo-N-cyclopropylmethyl-4,5-epoxy-6,14-ethylene-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylbutyl-2-alcohol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 13 h / 20 °C / Cooling with ice
2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3: bromine / dichloromethane / 1 h / 30 °C / Cooling with ice
View Scheme
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