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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Loteprednol etabonate

Cas:82034-46-6

Min.Order:10 Gram

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Shandong Kehui Pharmaceutical Co., Ltd

Shandong Kehui Pharmaceutical Co., Ltd. is a modern high-tech pharmaceutical company that strictly complies with GMP requirements and produces high standards. The company was established in May 2017 and is located in the Yellow River Delta Medicine V

Loteprednol Etabonate

Cas:82034-46-6

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Loteprednol etabonate

Cas:82034-46-6

Min.Order:1 Kilogram

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance A white or off white crystalline powder Conform Solubility

High purity 82034-46-6 Loteprednol Etabonate

Cas:82034-46-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Loteprednol Etabonate supplier in China

Cas:82034-46-6

Min.Order:0 Metric Ton

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Loteprednol etabonate

Cas:82034-46-6

Min.Order:1 Kilogram

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Loteprednol Etabonate

Cas:82034-46-6

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Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing

Loteprednol etabonate

Cas:82034-46-6

Min.Order:1 Kilogram

FOB Price: $10.0

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Loteprednol etabonate 82034-46-6 GMP Manufacturer

Cas:82034-46-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ

loteprednol etabonate CAS 82034-46-6

Cas:82034-46-6

Min.Order:10 Gram

FOB Price: $20.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

loteprednol etabonate

Cas:82034-46-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:chloromethyl CAS:82034-46-6 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability

High purity 82034-46-6 Loteprednol Etabonate

Cas:82034-46-6

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Loteprednol etabonate

Cas:82034-46-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM -- Loteprednol etabonate

Cas:82034-46-6

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Best PurityCAS 82034-46-6 with high quality products

Cas:82034-46-6

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Loteprednol etabonate/ LIDE PHARMA- Factory supply / Best price

Cas:82034-46-6

Min.Order:0

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Powder Storage:Store in sealed containers at cool & d

Top quality Loteprednol etabonate / CAS 82034-46-6

Cas:82034-46-6

Min.Order:100 Gram

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Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Loteprednol etabonate Molecular Structure: Formula: C24H31ClO7 Molecular Weight : 466.95 Synonyms: LOTEPREDNOLETABONATE;Androsta-1,4-diene-17-carboxylicac

Factory Supply Loteprednol etabonate

Cas:82034-46-6

Min.Order:1 Kilogram

Negotiable

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Qingdao Beluga Import and Export Co., LTD

Loteprednol etabonate CAS: 82034-46-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in

Loteprednol etabonate CAS: 82034-46-6

Cas:82034-46-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Chinese suppliers CAS 82034-46-6 Loteprednol etabonate

Cas:82034-46-6

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Androsta-1,4-diene-17-carboxylicacid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (11b,17a)-

Cas:82034-46-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Loteprednol etabonate with high quality

Cas:82034-46-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Package:in aluminum bag and foil bag or as customers' require Application:82034-46-6 Transportat

Loteprednol etabonate

Cas:82034-46-6

Min.Order:1 Gram

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Type:Other

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Loteprednol etabonate

Cas:82034-46-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Maytime Bio-Tech Co.,Ltd.

Top Supplier for loteprednol etabonate, Appearance:white or almost white powder Storage:store in well closed container Package:250grams/Al-foil bottle. 1kg/carton Application:loteprednol etabonate Transportation:non-dangerous material. Port:hangzh

loteprednol etabonate

Cas:82034-46-6

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Loteprednol etabonate

Cas:82034-46-6

Min.Order:0 Metric Ton

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Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Loteprednol etabonate

Cas:82034-46-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Loteprednol etabonate

Cas:82034-46-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Loteprednol etabonate

Cas:82034-46-6

Min.Order:1 Gram

Negotiable

Type:Other

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Synthetic route

chlorosulfuric acid chloromethyl ester
49715-04-0

chlorosulfuric acid chloromethyl ester

17α-ethoxycarbonyloxy-11β-hydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic acid

17α-ethoxycarbonyloxy-11β-hydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic acid

Loteprednol etabonate
82034-46-6

Loteprednol etabonate

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane at 20℃; for 2h; Time;92.8%
C24H33NO6

C24H33NO6

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

Loteprednol etabonate
82034-46-6

Loteprednol etabonate

Conditions
ConditionsYield
With dipotassium peroxodisulfate; potassium chloride for 3.5h; Reflux;92.6%
Chloroiodomethane
593-71-5

Chloroiodomethane

17α-[(ethoxycarbonyl)oxy]-11β-hydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic ethoxycarboxylic anhydride

17α-[(ethoxycarbonyl)oxy]-11β-hydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic ethoxycarboxylic anhydride

Loteprednol etabonate
82034-46-6

Loteprednol etabonate

Conditions
ConditionsYield
Stage #1: 17α-[(ethoxycarbonyl)oxy]-11β-hydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic ethoxycarboxylic anhydride With sodium ethanolate In N,N,N,N,N,N-hexamethylphosphoric triamide at 20℃; for 24h; Large scale;
Stage #2: Chloroiodomethane In N,N,N,N,N,N-hexamethylphosphoric triamide at 20℃; for 2h; Large scale;
89%
prednisolon
50-24-8

prednisolon

Loteprednol etabonate
82034-46-6

Loteprednol etabonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium periodate / methanol; water / 0.5 h / Heating; Large scale
2.1: triethylamine / dichloromethane / 0.5 h / 0 - 10 °C / Large scale
3.1: sodium ethanolate / N,N,N,N,N,N-hexamethylphosphoric triamide / 24 h / 20 °C / Large scale
3.2: 2 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 4 steps
1: sodium periodate / tetrahydrofuran; methanol; water / 2 h / 20 °C
2: sodium hydrogencarbonate; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 3 h / 20 °C
3: diethylamine / water / pH 2 - 3
4: sodium hydrogencarbonate; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 2 h / 20 °C
View Scheme
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0 02,7. 011,15]heptadeca-3,6-diene-14-carboxylic acid
37927-29-0

(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0 02,7. 011,15]heptadeca-3,6-diene-14-carboxylic acid

Loteprednol etabonate
82034-46-6

Loteprednol etabonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 3 h / 20 °C
2: diethylamine / water / pH 2 - 3
3: sodium hydrogencarbonate; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 2 h / 20 °C
View Scheme
C26H30N2O6

C26H30N2O6

Loteprednol etabonate
82034-46-6

Loteprednol etabonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium hydrogencarbonate; glycidyl methyl ether / 15 h / 50 - 60 °C / Inert atmosphere
2: triethylamine / dichloromethane / 2 h / 0 - 5 °C / Inert atmosphere
3: potassium chloride; dipotassium peroxodisulfate / 3.5 h / Reflux
View Scheme
C26H30N2O6

C26H30N2O6

Loteprednol etabonate
82034-46-6

Loteprednol etabonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium acetate; epichlorohydrin / 15 h / 50 - 60 °C / Inert atmosphere
2: triethylamine / dichloromethane / 2 h / 0 - 5 °C / Inert atmosphere
3: potassium chloride; dipotassium peroxodisulfate / 3.5 h / Reflux
View Scheme
1,4-androstadien-11β-hydroxy-3-one-17α-hydroxynitrile

1,4-androstadien-11β-hydroxy-3-one-17α-hydroxynitrile

Loteprednol etabonate
82034-46-6

Loteprednol etabonate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate; copper(I) trifluoromethanesolfonate toluene complex / tetrahydrofuran / 5 h / Inert atmosphere; Reflux
2: potassium hydrogencarbonate; glycidyl methyl ether / 15 h / 50 - 60 °C / Inert atmosphere
3: triethylamine / dichloromethane / 2 h / 0 - 5 °C / Inert atmosphere
4: potassium chloride; dipotassium peroxodisulfate / 3.5 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: caesium carbonate; copper(l) iodide / 2-methyltetrahydrofuran / 5 h / Inert atmosphere; Reflux
2: potassium acetate; epichlorohydrin / 15 h / 50 - 60 °C / Inert atmosphere
3: triethylamine / dichloromethane / 2 h / 0 - 5 °C / Inert atmosphere
4: potassium chloride; dipotassium peroxodisulfate / 3.5 h / Reflux
View Scheme
Loteprednol etabonate
82034-46-6

Loteprednol etabonate

(8S,10S,13S,14S,17R)-17-Ethoxycarbonyloxy-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid chloromethyl ester
207670-55-1

(8S,10S,13S,14S,17R)-17-Ethoxycarbonyloxy-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid chloromethyl ester

Conditions
ConditionsYield
With sulfuryl dichloride; triethylamine In toluene at -20 - 22℃; for 4h;89%
Loteprednol etabonate
82034-46-6

Loteprednol etabonate

(8S,9S,10R,13S,14S,17R)-17-Ethoxycarbonyloxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid chloromethyl ester

(8S,9S,10R,13S,14S,17R)-17-Ethoxycarbonyloxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid chloromethyl ester

Conditions
ConditionsYield
With acetic anhydride; dimethyl sulfoxide at 22℃; for 72h;72%
Loteprednol etabonate
82034-46-6

Loteprednol etabonate

chloromethyl 1β,11β-epoxy-17α-ethoxycarbonyloxy-2-oxo-10α-androsta-4-ene-17β-carboxylate

chloromethyl 1β,11β-epoxy-17α-ethoxycarbonyloxy-2-oxo-10α-androsta-4-ene-17β-carboxylate

Conditions
ConditionsYield
In water; acetonitrile at 25℃; for 472h; Photolysis;21%
Loteprednol etabonate
82034-46-6

Loteprednol etabonate

A

chloromethyl 17α-ethoxycarbonyloxy-11β-hydroxy-1-methyl-3-oxo-6(5->10α)-abeo-19-norandrosta-1,4-diene-17β-carboxylate

chloromethyl 17α-ethoxycarbonyloxy-11β-hydroxy-1-methyl-3-oxo-6(5->10α)-abeo-19-norandrosta-1,4-diene-17β-carboxylate

B

chloromethyl 17α-ethoxycarbonyloxy-11β-hydroxy-5α-methyl-2-oxo-19-norandrosta-1(10),3-diene-17β-carboxylate

chloromethyl 17α-ethoxycarbonyloxy-11β-hydroxy-5α-methyl-2-oxo-19-norandrosta-1(10),3-diene-17β-carboxylate

Conditions
ConditionsYield
In water at 25℃; for 472h; Photolysis;A 0.4%
B 1.2%
Loteprednol etabonate
82034-46-6

Loteprednol etabonate

A

(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0 02,7. 011,15]heptadeca-3,6-diene-14-carboxylic acid
37927-29-0

(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0 02,7. 011,15]heptadeca-3,6-diene-14-carboxylic acid

B

17α-ethoxycarbonyloxy-11β-hydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic acid

17α-ethoxycarbonyloxy-11β-hydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic acid

Conditions
ConditionsYield
With heptakis(2,6-di-O-methyl)cyclomaltoheptaose; water at 37℃; Kinetics; Activation energy; Further Variations:; Temperatures; Reagents; Solvents; Hydrolysis;
Loteprednol etabonate
82034-46-6

Loteprednol etabonate

(8S,9R,10S,11S,13S,14S,17R)-9,11-Dichloro-17-ethoxycarbonyloxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid chloromethyl ester

(8S,9R,10S,11S,13S,14S,17R)-9,11-Dichloro-17-ethoxycarbonyloxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid chloromethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / SO2Cl2, Et3N / toluene / 4 h / -20 - 22 °C
2: 54 percent / SO2Cl2, pyridine / chlorobenzene / 3 h / -10 - 0 °C
View Scheme
Multi-step reaction with 2 steps
1: 89 percent / SO2Cl2, Et3N / toluene / 4 h / -20 - 22 °C
2: 34 percent / Cl2, H2O, pyridine / CCl4; benzene / 10 h / 5 °C
View Scheme
Loteprednol etabonate
82034-46-6

Loteprednol etabonate

(8S,9R,10S,11S,13S,14S,17R)-9-Chloro-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid chloromethyl ester

(8S,9R,10S,11S,13S,14S,17R)-9-Chloro-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid chloromethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / SO2Cl2, Et3N / toluene / 4 h / -20 - 22 °C
2: 16 percent / Cl2, H2O, pyridine / CCl4; benzene / 10 h / 5 °C
View Scheme
Loteprednol etabonate
82034-46-6

Loteprednol etabonate

chloromethyl 9,11α-epoxy-17α-ethoxycarbonyloxy-3-oxoandrosta-1,4-diene-17β-carboxylate
207670-56-2

chloromethyl 9,11α-epoxy-17α-ethoxycarbonyloxy-3-oxoandrosta-1,4-diene-17β-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / SO2Cl2, Et3N / toluene / 4 h / -20 - 22 °C
2: 7.68 g / 3-chloroperoxybenzoic acid / CHCl3 / 120 h / 22 °C
View Scheme
Loteprednol etabonate
82034-46-6

Loteprednol etabonate

cyanomethyl 9,11α-epoxy-17α-ethoxycarbonyloxy-3-oxoandrosta-1,4-diene-17β-carboxylate

cyanomethyl 9,11α-epoxy-17α-ethoxycarbonyloxy-3-oxoandrosta-1,4-diene-17β-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 89 percent / SO2Cl2, Et3N / toluene / 4 h / -20 - 22 °C
2: 7.68 g / 3-chloroperoxybenzoic acid / CHCl3 / 120 h / 22 °C
3: 14 percent / lithium perchlorate / acetonitrile / 75 h / 70 °C
View Scheme
Loteprednol etabonate
82034-46-6

Loteprednol etabonate

azidomethyl 9,11α-epoxy-17α-ethoxycarbonyloxy-3-oxoandrosta-1,4-diene-17β-carboxylate

azidomethyl 9,11α-epoxy-17α-ethoxycarbonyloxy-3-oxoandrosta-1,4-diene-17β-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 89 percent / SO2Cl2, Et3N / toluene / 4 h / -20 - 22 °C
2: 7.68 g / 3-chloroperoxybenzoic acid / CHCl3 / 120 h / 22 °C
3: 33 percent / LiN3 / acetonitrile / 50 h / 70 °C
View Scheme
Loteprednol etabonate
82034-46-6

Loteprednol etabonate

loteprednol etabonate monohydrate

loteprednol etabonate monohydrate

Conditions
ConditionsYield
With water In acetone at 50℃; under 112511 Torr; Solvent; Pressure; Supercritical conditions;

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