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Hangzhou Think Chemical Co. Ltd

Elagolix CAS No.:834153-87-6 Name: Elagolix Synonyms: 4-[[(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidin

High purity Elagolix CAS No.:834153-87-6

Cas:834153-87-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% elagolix 834153-87-6 GMP Manufacturer

Cas:834153-87-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality elagolix

Cas:834153-87-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Elagolix

Cas:834153-87-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFUCHEM elagolix

Cas:834153-87-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Elagolix / LIDE PHARMA- Factory supply / Best price

Cas:834153-87-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 834153-87-6 with competitive price

Cas:834153-87-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 834153-87-6 Elagolix

Cas:834153-87-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developmen

elagolix

Cas:834153-87-6

Min.Order:1 Kilogram

FOB Price: $23.0 / 25.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

Elagolix

Cas:834153-87-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Elagolix Structure: Formula: C32H30F5N3O5 Molecular Weight : 631.59 Synonyms: elagolix;4-[[(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluorome

Factory Supply Elagolix

Cas:834153-87-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

elagolix CAS:834153-87-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

elagolix CAS:834153-87-6

Cas:834153-87-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Elagolix manufacturer with low price

Cas:834153-87-6

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd,Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all em

Elagolix Sodium CAS: 834153-87-6

Cas:834153-87-6

Min.Order:1 Gram

FOB Price: $100.0

Type:Trading Company

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

NBI56418 Elagolix 834153-87-6

Cas:834153-87-6

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ELAGOLIX

Cas:834153-87-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

elagolix/High quality/Best price

Cas:834153-87-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Elagolix

Cas:834153-87-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Elagolix

Cas:834153-87-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

elagolix

Cas:834153-87-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Elagolix CAS No.:834153-87-6 Molecule Formula:C32H30F5N3O5 Molecule Weight:631.59 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPE

Best Quality Elagolix with good supplier

Cas:834153-87-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

1. DMF is available. 2. Under registerring in Russia and Turkey. Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huaro

Elagolix

Cas:834153-87-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

elagolix

Cas:834153-87-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

elagolixCAS NO.: 834153-87-6

Cas:834153-87-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Elagolix

Cas:834153-87-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

elagolix Chemical Properties Boiling point 728.6±70.0 °C(Predicted) density 1.350 pka 4.40±0.10(Predicted) Appearance:powder Storage:

Elagolix

Cas:834153-87-6

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Elagolix

Cas:834153-87-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Synthetic route

4-((R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-trifluoromethylbenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-yl]-1-phenylethylamino)butyric acid ethyl ester
832720-84-0

4-((R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-trifluoromethylbenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-yl]-1-phenylethylamino)butyric acid ethyl ester

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Stage #1: ethyl (R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoate With sodium hydroxide; water In ethanol at 35℃; for 2h;
Stage #2: With hydrogenchloride In water at 10 - 22℃; for 17h; pH=6.1;
91%
With water; sodium hydroxide In ethanol at 35℃;86%
With water; sodium hydroxide In ethanol at 50℃; for 2h;83.59%
(R)-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-3-[2-(2-oxopyrrolidin-1-yl)-2-phenylethyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

(R)-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-3-[2-(2-oxopyrrolidin-1-yl)-2-phenylethyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol at 55 - 60℃;89%
ethyl (R)-4-((tert-butoxycarbonyl)(2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1-(2H)-yl)-1-phenylethyl)amino)butyrate

ethyl (R)-4-((tert-butoxycarbonyl)(2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1-(2H)-yl)-1-phenylethyl)amino)butyrate

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
With water; potassium carbonate In tetrahydrofuran at 50℃; for 6h; Solvent; Temperature;82%
3-[(2R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione trifluoroacetate
830346-50-4

3-[(2R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione trifluoroacetate

Succinic semialdehyde
692-29-5

Succinic semialdehyde

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 25℃; for 18h; Reagent/catalyst; Solvent; Temperature;65%
methyl (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-[2-fluoro-6-(trifluoromethyl)benzyl]-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate
1092070-97-7

methyl (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-[2-fluoro-6-(trifluoromethyl)benzyl]-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
With water; lithium hydroxide In methanol at 45℃;
3-[(2R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione trifluoroacetate
830346-50-4

3-[(2R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione trifluoroacetate

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 52 °C
2: sodium hydroxide; water / ethanol / 35 °C
View Scheme
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
2: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
2: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione
1150560-59-0

5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 55 °C
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 52 °C
3: sodium hydroxide; water / ethanol / 35 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
3: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
3: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione
1150560-54-5

1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium hydroxide; tri tert-butylphosphoniumtetrafluoroborate / acetone; water / 0.83 h / 15 - 45 °C
2: potassium carbonate / N,N-dimethyl-formamide / 55 °C
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 52 °C
4: sodium hydroxide; water / ethanol / 35 °C
View Scheme
(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium hydroxide; tri tert-butylphosphoniumtetrafluoroborate / acetone; water / 0.83 h / 15 - 45 °C
2: potassium carbonate / N,N-dimethyl-formamide / 55 °C
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 52 °C
4: sodium hydroxide; water / ethanol / 35 °C
View Scheme
Multi-step reaction with 7 steps
1.1: methanol; water / 24 h / 70 °C
2.1: tetra(n-butyl)ammonium hydroxide / water / 0.03 h / Inert atmosphere
2.2: 1 h / 80 °C / Inert atmosphere
3.1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux
4.1: toluene / 4 h / Reflux
4.2: 2 h / Reflux
5.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
7.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 7 steps
1.1: methanol; water / 24 h / 70 °C
2.1: tetra(n-butyl)ammonium hydroxide / water / 0.03 h / Inert atmosphere
2.2: 1 h / 80 °C / Inert atmosphere
3.1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux
4.1: toluene / 4 h / Reflux
4.2: 2 h / Reflux
5.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
7.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 7 steps
1.1: methanol; water / 24 h / 70 °C
2.1: tetra(n-butyl)ammonium hydroxide / water / 0.03 h / Inert atmosphere
2.2: 1 h / 80 °C / Inert atmosphere
3.1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux
4.1: toluene / 4 h / Reflux
4.2: 2 h / Reflux
5.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
7.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 7 steps
1.1: methanol; water / 24 h / 70 °C
2.1: tetra(n-butyl)ammonium hydroxide / water / 0.03 h / Inert atmosphere
2.2: 1 h / 80 °C / Inert atmosphere
3.1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux
4.1: toluene / 4 h / Reflux
4.2: 2 h / Reflux
5.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
7.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
(S)-(+)-<2-<(methylsulfonyl)oxy>-1-phenylethyl>carbamic acid 1,1-dimethylethyl ester
110143-62-9

(S)-(+)-<2-<(methylsulfonyl)oxy>-1-phenylethyl>carbamic acid 1,1-dimethylethyl ester

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 55 °C
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 52 °C
3: sodium hydroxide; water / ethanol / 35 °C
View Scheme
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid
2900-27-8

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 10 °C
2: potassium carbonate / N,N-dimethyl-formamide / 55 °C
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 52 °C
4: sodium hydroxide; water / ethanol / 35 °C
View Scheme
2-(2-fluoro-3-methoxyphenyl)-3-oxo-butyric acid ethyl ester

2-(2-fluoro-3-methoxyphenyl)-3-oxo-butyric acid ethyl ester

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene / 105 - 110 °C
1.2: 105 - 110 °C
2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 90 - 100 °C
3.1: sodium hydroxide; water / ethanol / 55 - 60 °C
View Scheme
Multi-step reaction with 4 steps
1.1: toluene / 4 h / Reflux
1.2: 2 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
4.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: toluene / 4 h / Reflux
1.2: 2 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
4.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
5-bromo-6-methyluracil
15018-56-1

5-bromo-6-methyluracil

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 75 - 85 °C
2: iron(III)-acetylacetonate; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0 - 45 °C
3: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 90 - 100 °C
4: sodium hydroxide; water / ethanol / 55 - 60 °C
View Scheme
1-(bromomethyl)-2-fluoro-6-(trifluoromethyl)benzene
239087-08-2

1-(bromomethyl)-2-fluoro-6-(trifluoromethyl)benzene

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 75 - 85 °C
2: iron(III)-acetylacetonate; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0 - 45 °C
3: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 90 - 100 °C
4: sodium hydroxide; water / ethanol / 55 - 60 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: iron(III)-acetylacetonate; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0 - 45 °C
2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 90 - 100 °C
3: sodium hydroxide; water / ethanol / 55 - 60 °C
View Scheme
1-bromo-2-fluoro-3-methoxybenzene
295376-21-5

1-bromo-2-fluoro-3-methoxybenzene

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 45 - 50 °C / Inert atmosphere
2.1: toluene / 105 - 110 °C
2.2: 105 - 110 °C
3.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 90 - 100 °C
4.1: sodium hydroxide; water / ethanol / 55 - 60 °C
View Scheme
2-(2-fluoro-3-methoxyphenyl)-3-oxo-butyric acid tert-butyl ester

2-(2-fluoro-3-methoxyphenyl)-3-oxo-butyric acid tert-butyl ester

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene / 4 h / Reflux
1.2: 2 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
4.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: toluene / 4 h / Reflux
1.2: 2 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
4.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
2-(2-fluoro-3-methoxyphenyl)-3-oxo-butyric acid benzyl ester

2-(2-fluoro-3-methoxyphenyl)-3-oxo-butyric acid benzyl ester

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene / 4 h / Reflux
1.2: 2 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
4.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: toluene / 4 h / Reflux
1.2: 2 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
4.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
2-(2-fluoro-3-methoxyphenyl)-3-oxo-butyric acid methyl ester

2-(2-fluoro-3-methoxyphenyl)-3-oxo-butyric acid methyl ester

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene / 4 h / Reflux
1.2: 2 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
4.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: toluene / 4 h / Reflux
1.2: 2 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
4.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
(2-fluoro-6-(trifluoromethyl) phenyl)methanamine
239087-06-0

(2-fluoro-6-(trifluoromethyl) phenyl)methanamine

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride / water / 3 h / Reflux
2.1: toluene / 4 h / Reflux
2.2: 2 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogenchloride / water / 3 h / Reflux
2.1: toluene / 4 h / Reflux
2.2: 2 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogenchloride / water / 3 h / Reflux
2.1: toluene / 4 h / Reflux
2.2: 2 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
2-fluoro-6-(trifluoromethyl)benzaldehyde
60611-24-7

2-fluoro-6-(trifluoromethyl)benzaldehyde

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: hydroxylamine hydrochloride; sodium hydroxide / water; ethanol / 1 h
1.2: 2 h
2.1: hydrogenchloride / water / 3 h / Reflux
3.1: toluene / 4 h / Reflux
3.2: 2 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1.1: hydroxylamine hydrochloride; sodium hydroxide / water; ethanol / 1 h
1.2: 2 h
2.1: hydrogenchloride / water / 3 h / Reflux
3.1: toluene / 4 h / Reflux
3.2: 2 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1.1: hydroxylamine hydrochloride; sodium hydroxide / water; ethanol / 1 h
1.2: 2 h
2.1: hydrogenchloride / water / 3 h / Reflux
3.1: toluene / 4 h / Reflux
3.2: 2 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}urea
830346-46-8

N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}urea

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene / 4 h / Reflux
1.2: 2 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
4.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: toluene / 4 h / Reflux
1.2: 2 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
4.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: toluene / 4 h / Reflux
1.2: 2 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
4.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
potassium 2-fluoro-3-methoxy-phenyl-1-trifluoroborate

potassium 2-fluoro-3-methoxy-phenyl-1-trifluoroborate

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: tetra(n-butyl)ammonium hydroxide / water / 0.03 h / Inert atmosphere
1.2: 1 h / 80 °C / Inert atmosphere
2.1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux
3.1: toluene / 4 h / Reflux
3.2: 2 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1.1: tetra(n-butyl)ammonium hydroxide / water / 0.03 h / Inert atmosphere
1.2: 1 h / 80 °C / Inert atmosphere
2.1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux
3.1: toluene / 4 h / Reflux
3.2: 2 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1.1: tetra(n-butyl)ammonium hydroxide / water / 0.03 h / Inert atmosphere
1.2: 1 h / 80 °C / Inert atmosphere
2.1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux
3.1: toluene / 4 h / Reflux
3.2: 2 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1.1: tetra(n-butyl)ammonium hydroxide / water / 0.03 h / Inert atmosphere
1.2: 1 h / 80 °C / Inert atmosphere
2.1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux
3.1: toluene / 4 h / Reflux
3.2: 2 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
5-(2-fluoro-3-methoxyphenyl)-2,2,6-trimethyl-4H-1,3-dioxin-4-one

5-(2-fluoro-3-methoxyphenyl)-2,2,6-trimethyl-4H-1,3-dioxin-4-one

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux
2.1: toluene / 4 h / Reflux
2.2: 2 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux
2.1: toluene / 4 h / Reflux
2.2: 2 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux
2.1: toluene / 4 h / Reflux
2.2: 2 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux
2.1: toluene / 4 h / Reflux
2.2: 2 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
2-fluoro-1-iodo-3-methoxybenzene
1080673-30-8

2-fluoro-1-iodo-3-methoxybenzene

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: copper(l) iodide; 4R-4-hydroxyproline; caesium carbonate / dimethyl sulfoxide / 96 h / 60 °C / Heating
2.1: toluene / 4 h / Reflux
2.2: 2 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1.1: copper(l) iodide; 4R-4-hydroxyproline; caesium carbonate / dimethyl sulfoxide / 96 h / 60 °C / Heating
2.1: toluene / 4 h / Reflux
2.2: 2 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1.1: copper(l) iodide; 4R-4-hydroxyproline; caesium carbonate / dimethyl sulfoxide / 96 h / 60 °C / Heating
2.1: toluene / 4 h / Reflux
2.2: 2 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1.1: copper(l) iodide; 4R-4-hydroxyproline; caesium carbonate / dimethyl sulfoxide / 96 h / 60 °C / Heating
2.1: toluene / 4 h / Reflux
2.2: 2 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
1-fluoro-2-methoxybenzene
321-28-8

1-fluoro-2-methoxybenzene

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: N,N,N',N'',N'''-pentamethyldiethylenetriamine; n-butyllithium / tetrahydrofuran / 1 h / -78 °C
1.2: 2 h / -78 °C
2.1: copper(l) iodide; 4R-4-hydroxyproline; caesium carbonate / dimethyl sulfoxide / 96 h / 60 °C / Heating
3.1: toluene / 4 h / Reflux
3.2: 2 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1.1: N,N,N',N'',N'''-pentamethyldiethylenetriamine; n-butyllithium / tetrahydrofuran / 1 h / -78 °C
1.2: 2 h / -78 °C
2.1: copper(l) iodide; 4R-4-hydroxyproline; caesium carbonate / dimethyl sulfoxide / 96 h / 60 °C / Heating
3.1: toluene / 4 h / Reflux
3.2: 2 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1.1: N,N,N',N'',N'''-pentamethyldiethylenetriamine; n-butyllithium / tetrahydrofuran / 1 h / -78 °C
1.2: 2 h / -78 °C
2.1: copper(l) iodide; 4R-4-hydroxyproline; caesium carbonate / dimethyl sulfoxide / 96 h / 60 °C / Heating
3.1: toluene / 4 h / Reflux
3.2: 2 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1.1: N,N,N',N'',N'''-pentamethyldiethylenetriamine; n-butyllithium / tetrahydrofuran / 1 h / -78 °C
1.2: 2 h / -78 °C
2.1: copper(l) iodide; 4R-4-hydroxyproline; caesium carbonate / dimethyl sulfoxide / 96 h / 60 °C / Heating
3.1: toluene / 4 h / Reflux
3.2: 2 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 100 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 2 h / 50 °C
View Scheme
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

elagolix phosphoric acid salt

elagolix phosphoric acid salt

Conditions
ConditionsYield
With phosphoric acid In ethyl acetate at 0 - 10℃;93.6%
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 1 h / 60 °C
2: phosphoric acid / water / 25 °C
View Scheme
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

(R)-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-3-[2-(2-oxopyrrolidin-1-yl)-2-phenylethyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

(R)-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-3-[2-(2-oxopyrrolidin-1-yl)-2-phenylethyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

Conditions
ConditionsYield
With dmap; di-tert-butyl dicarbonate In acetonitrile92%
Stage #1: 4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid With triethylamine In dichloromethane at 20℃; for 1h;
Stage #2: With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 24h;
64.8%
In butanone at 25℃; for 168h;93.03 %Chromat.
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 1 h / 60 °C
2: butanone / 168 h / 25 °C
View Scheme
formaldehyd
50-00-0

formaldehyd

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

(R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-[2-fluoro-6-(trifluoromethyl)benzyl]-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethyl-N-methylamino}butyric acid

(R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-[2-fluoro-6-(trifluoromethyl)benzyl]-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethyl-N-methylamino}butyric acid

Conditions
ConditionsYield
With borane pyridine complex In methanol at 20℃;
With borane pyridine In methanol
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

sodium 4-({(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}amino)butanoate

sodium 4-({(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}amino)butanoate

Conditions
ConditionsYield
With Dowex MSC-11.58 g
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

sodium 3-[2(R)-{hydroxycarbonylpropylamino}-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-((2H3)-methyl)-3H-pyrimidine-2,4-dione

sodium 3-[2(R)-{hydroxycarbonylpropylamino}-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-((2H3)-methyl)-3H-pyrimidine-2,4-dione

Conditions
ConditionsYield
With water-d2; sodium carbonate for 15h; Reflux;
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

3-[2(R)-{hydroxycarbonylpropylamino}-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-((2H3)-methyl)-3H-pyrimidine-2,4-dione

3-[2(R)-{hydroxycarbonylpropylamino}-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-((2H3)-methyl)-3H-pyrimidine-2,4-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate; water-d2 / 15 h / Reflux
2: sodium carbonate; water-d2 / 15 h / Reflux
View Scheme
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

elagolix hydrochloride

elagolix hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 1 h / 60 °C
2: hydrogenchloride / water / 25 °C
View Scheme
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

elagolix hydrobromide

elagolix hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 1 h / 60 °C
2: hydrogen bromide / water / 25 °C
View Scheme
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

elagolix nitrate

elagolix nitrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 1 h / 60 °C
2: nitric acid / water / 25 °C
View Scheme
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

elagolix, sulfuric acid salt

elagolix, sulfuric acid salt

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 1 h / 60 °C
2: sulfuric acid / water / 25 °C
View Scheme
With sulfuric acid In acetonitrile at 27℃; Solvent; Temperature;
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

C32H29F5N3O5(1-)*K(1+)

C32H29F5N3O5(1-)*K(1+)

Conditions
ConditionsYield
With potassium hydroxide In water at 60℃; for 1h;3.7 g
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

2C32H29F5N3O5(1-)*Ca(2+)

2C32H29F5N3O5(1-)*Ca(2+)

Conditions
ConditionsYield
With calcium acetate In water at 60℃; for 1h;3.5 g
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

Pamoic acid
130-85-8

Pamoic acid

elagolix pamoic acid salt (1:1)

elagolix pamoic acid salt (1:1)

Conditions
ConditionsYield
In methanol at 25 - 60℃; for 19h;1.5 g
4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid
834153-87-6

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

benzenesulfonic acid
98-11-3

benzenesulfonic acid

elagolix benzenesulfonic acid salt

elagolix benzenesulfonic acid salt

Conditions
ConditionsYield
In methanol at 20 - 60℃; for 26h;1.1 g

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