As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryIntroduction Benazepril hydrochloride is the main ingredient in benazepril hydrochloride tablets.The mechanism of action is that it can inhibit the activity of angiotensin-converting enzyme, which can relieve a series of symptoms caused by angiotens
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white crystalline powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:medicine r
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
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inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryProduct Name: Benazepril hydrochloride CAS: 86541-74-4 Synonyms:1h-1-benzazepine-1-aceticacid,2,3,4,5-tetrahydro-3-((1-(ethoxycarbonyl)-3-phe;cgs14824a;monohydrochloride,(s-(r*,r*))-nylpropyl)amino)-2-oxo;BenazeprilHclC24H28N205.HC1;1H
Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua
Cas:86541-74-4
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inquiry1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Benazepril hydrochloride Molecular Structure: Formula: C24H29ClN2O5 Molecular Weight :460.95 Synonyms: 1h-1-benzazepine-1-aceticacid,2,3,4,5-tetrahydro-3-
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:86541-74-4
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inquiryHebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many o
Cas:86541-74-4
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inquiryProduct Name: Benazepril hydrochloride Synonyms: 1h-1-benzazepine-1-aceticacid,2,3,4,5-tetrahydro-3-((1-(ethoxycarbonyl)-3-phe;cgs14824a;monohydrochloride,(s-(r*,r*))-nylpropyl)amino)-2-oxo;BenazeprilHclC24H28N205.HC1;1H-1-Benzazepine-1-acetic a
Cas:86541-74-4
Min.Order:100 Gram
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inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:86541-74-4
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiry(Synonyms:1h-1-benzazepine-1-aceticacid,2,3,4,5-tetrahydro-3-((1-(ethoxycarbonyl)-3-phe cgs14824a monohydrochloride,(s-(r*,r*))-nylpropyl)amino)-2-oxo BenazeprilHclC24H28N205.HC1 1H-1-Benzazepine-1-acetic acid, 3-(1S)-1-(ethoxycarbonyl)-3-pheny
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as an antihypertensive Transportation:
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:86541-74-4
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryOur Advantages: 1. A strong scientific research team (40people in the research team, including 7 Doctors, 13Masters...). 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch o
Cas:86541-74-4
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inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
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inquiryAntihypertensive API 99% Purity Bulk Benazepril Hydrochloride Benazepril HCl Powder cas 86541-74-4Name: Benazepril hydrochloride CAS: 86541-74-4 MF: C24H29ClN2O5 MW: 460.95 EINECS: 630-414-2 Melting point 188-190°C storage tem
Cas:86541-74-4
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Negotiable
Type:Trading Company
inquiryBenazepril hydrochloride Basic information Product Name: Benazepril hydrochloride Synonyms: 1h-1-benzazepine-1-aceticacid,2,3,4,5-tetrahydro-3-((1-(ethoxycarbonyl)-3-phe;cgs14824a;monohydrochloride,(s-(r*,r*))-nylpropyl)amino)-2-oxo;Benazepril
Cas:86541-74-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct name: Benazepril Hydrochloride CAS No.:86541-74-4 Molecule Formula:C24H29ClN2O5 Molecule Weight:460.95 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard
Cas:86541-74-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
Cas:86541-74-4
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inquiry(2S,3'S)-2-(1-tert-butoxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester
benazepril hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate | 91.6% |
With hydrogenchloride In toluene at 0 - 20℃; for 1.5h; | 90% |
With hydrogenchloride In ethyl acetate at -10 - 25℃; for 16h; Industry scale; | |
With hydrogenchloride In ethyl acetate at 10℃; under 760.051 Torr; Solvent; Reflux; | Ca. 114 g |
With hydrogenchloride In Isopropyl acetate at 10℃; | 99.6 g |
benazepril hydrochloride
Conditions | Yield |
---|---|
Stage #1: ethyl (S)-2-(((S)-1-(2-(benzyloxy)-2-oxoethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3- yl)amino)-4-phenylbutanoate With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 3h; Stage #2: With hydrogenchloride In ethyl acetate; acetone Reflux; | 91% |
2-oxo-4-phenylbutanoic acid ethyl ester
(3S)-3-amino-1-(carboxymethyl)-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one sodium salt
A
benazepril hydrochloride
B
(3S)-1-(carboxymethyl)-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one hydrochloride
Conditions | Yield |
---|---|
With sodium cyanoborohydride In methanol; acetic acid Ambient temperature; | A 12% B 25% |
2-acetylnitrobenzene
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 99 percent / sodium ethoxide / tetrahydrofuran / 2 h / 0 °C 2.1: phenacyl chloride; baker's yeast / diethyl ether; H2O / 24 h / 30 °C 3.1: H2; HCl / Pd/C / methanol / 20 °C 3.2: 42 percent / AcOH / toluene / 80 °C 4.1: Et3N / tetrahydrofuran / 16 h / 20 °C 5.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C 6.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 6.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 7.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 8 steps 1.1: 99 percent / sodium ethoxide / tetrahydrofuran / 2 h / 0 °C 2.1: phenacyl chloride; baker's yeast / diethyl ether; H2O / 24 h / 30 °C 3.1: NaBH4; acetic acid / 2 h / 0 °C 4.1: H2 / Pd/C / methanol / 24 h / 20 °C 4.2: H2; hydrochloric acid / Pd/C / methanol / 36 h / 20 °C 4.3: 74 percent / AcOH / toluene / 16 h / 80 °C 5.1: Et3N / tetrahydrofuran / 16 h / 20 °C 6.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C 7.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 7.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 8.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme |
4-(2-nitrophenyl)-2,4-dioxobutanoic acid ethyl ester
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: phenacyl chloride; baker's yeast / diethyl ether; H2O / 24 h / 30 °C 2.1: H2; HCl / Pd/C / methanol / 20 °C 2.2: 42 percent / AcOH / toluene / 80 °C 3.1: Et3N / tetrahydrofuran / 16 h / 20 °C 4.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C 5.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 5.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 6.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: phenacyl chloride; baker's yeast / diethyl ether; H2O / 24 h / 30 °C 2.1: NaBH4; acetic acid / 2 h / 0 °C 3.1: H2 / Pd/C / methanol / 24 h / 20 °C 3.2: H2; hydrochloric acid / Pd/C / methanol / 36 h / 20 °C 3.3: 74 percent / AcOH / toluene / 16 h / 80 °C 4.1: Et3N / tetrahydrofuran / 16 h / 20 °C 5.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C 6.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 6.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 7.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme |
ethyl 2-amino-4-phenyl-(2S)-butyrate
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C 2.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 2.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 3.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme |
(3R)-3-hydroxy-1,3,4,5-tetrahydrobenzo[b]azepin-2-one
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: Et3N / tetrahydrofuran / 16 h / 20 °C 2.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C 3.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 3.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 4.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme |
(2R)-2-hydroxy-4-(2-nitrophenyl)-4-oxobutyric acid ethyl ester
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: H2; HCl / Pd/C / methanol / 20 °C 1.2: 42 percent / AcOH / toluene / 80 °C 2.1: Et3N / tetrahydrofuran / 16 h / 20 °C 3.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C 4.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 4.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 5.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: NaBH4; acetic acid / 2 h / 0 °C 2.1: H2 / Pd/C / methanol / 24 h / 20 °C 2.2: H2; hydrochloric acid / Pd/C / methanol / 36 h / 20 °C 2.3: 74 percent / AcOH / toluene / 16 h / 80 °C 3.1: Et3N / tetrahydrofuran / 16 h / 20 °C 4.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C 5.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 5.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 6.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme |
(R)-2,4-Dihydroxy-4-(2-nitro-phenyl)-butyric acid ethyl ester
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: H2 / Pd/C / methanol / 24 h / 20 °C 1.2: H2; hydrochloric acid / Pd/C / methanol / 36 h / 20 °C 1.3: 74 percent / AcOH / toluene / 16 h / 80 °C 2.1: Et3N / tetrahydrofuran / 16 h / 20 °C 3.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C 4.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 4.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 5.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme |
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: phenacyl chloride; baker's yeast / diethyl ether; H2O / 24 h / 30 °C 1.2: H2; hydrochloric acid / Pd/C / methanol / 20 °C 1.3: AcOH / toluene / 80 °C 2.1: Et3N / tetrahydrofuran / 16 h / 20 °C 3.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C 4.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 4.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 5.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme |
4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C 2.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 2.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 3.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme |
(2S,3'S)-2-(2'-oxo-2',3',4',5'-tetrahydro-1H-benzo[b]azepin-3'-ylamino)-4-phenylbutyric acid ethyl ester
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 2.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme |
2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 90 percent / PCl5 / xylene / 0.5 h / 90 °C 2: 95 percent / H2, sodium acetate / 5percent Pd/C / acetic acid / 0.5 h / 760 Torr / Ambient temperature 3: 90 percent / sodium azide / dimethylsulfoxide / 3 h / 80 °C 4: 96 percent / Bu4NBr, KOH / tetrahydrofuran / 1.5 h / Ambient temperature 5: 93 percent / H2 / 10percent Pd/C / ethanol / 1.5 h / 2280 Torr / Ambient temperature 7: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature 8: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature View Scheme |
3,3-dichloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 95 percent / H2, sodium acetate / 5percent Pd/C / acetic acid / 0.5 h / 760 Torr / Ambient temperature 2: 90 percent / sodium azide / dimethylsulfoxide / 3 h / 80 °C 3: 96 percent / Bu4NBr, KOH / tetrahydrofuran / 1.5 h / Ambient temperature 4: 93 percent / H2 / 10percent Pd/C / ethanol / 1.5 h / 2280 Torr / Ambient temperature 6: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature 7: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature View Scheme |
3-chloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 90 percent / sodium azide / dimethylsulfoxide / 3 h / 80 °C 2: 96 percent / Bu4NBr, KOH / tetrahydrofuran / 1.5 h / Ambient temperature 3: 93 percent / H2 / 10percent Pd/C / ethanol / 1.5 h / 2280 Torr / Ambient temperature 5: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature 6: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature View Scheme |
3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 96 percent / Bu4NBr, KOH / tetrahydrofuran / 1.5 h / Ambient temperature 2: 93 percent / H2 / 10percent Pd/C / ethanol / 1.5 h / 2280 Torr / Ambient temperature 4: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature 5: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature View Scheme |
ethyl 3-azido-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one-1-acetate
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 93 percent / H2 / 10percent Pd/C / ethanol / 1.5 h / 2280 Torr / Ambient temperature 3: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature 4: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature View Scheme |
3-(S)-amino-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 2: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature 3: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature View Scheme |
(S)-3-amino-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature 2: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature View Scheme |
3-[[1-(t-butoxy-carbonyl)-3-phenyl-(1S)-propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic acid ethyl ester
benazepril hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate at 0℃; for 2 - 3h; |
benazepril
benazepril hydrochloride
Conditions | Yield |
---|---|
Stage #1: benazepril With Celite; pyrographite In acetone for 1h; Heating / reflux; Industry scale; Stage #2: With hydrogenchloride In water; acetone at 10 - 50℃; for 3h; |
2-oxo-4-phenylbutanoic acid ethyl ester
(3S)-3-amino-1-(carboxymethyl)-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one sodium salt
benazepril hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; sodium cyanoborohydride In methanol; dichloromethane; acetic acid; butanone | |
With hydrogenchloride; sodium cyanoborohydride In methanol; dichloromethane; acetic acid; butanone |
ethyl (R)-2-hydroxy-4-phenylbutyrate
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / ethyl acetate / 3 h / 0 - 25 °C 2: sodium carbonate / ethyl acetate / 20 h / 80 °C / 760.05 Torr 3: hydrogenchloride / ethyl acetate / 10 °C / 760.05 Torr / Reflux View Scheme |
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / methanol / 24 h / 60 °C 2.1: 1,1'-carbonyldiimidazole / Isopropyl acetate / 4 h / 20 °C 2.2: 4 h 3.1: hydrogenchloride / Isopropyl acetate / 10 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / isopropyl alcohol / 24 h / 60 °C 2.1: 1,1'-carbonyldiimidazole / Isopropyl acetate / 4 h / 20 °C 2.2: 4 h 3.1: hydrogenchloride / Isopropyl acetate / 10 °C View Scheme |
D-homophenylalanine
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / methanol / 24 h / 60 °C 2.1: 1,1'-carbonyldiimidazole / Isopropyl acetate / 4 h / 20 °C 2.2: 4 h 3.1: hydrogenchloride / Isopropyl acetate / 10 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / isopropyl alcohol / 24 h / 60 °C 2.1: 1,1'-carbonyldiimidazole / Isopropyl acetate / 4 h / 20 °C 2.2: 4 h 3.1: hydrogenchloride / Isopropyl acetate / 10 °C View Scheme |
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: trifluoroacetic acid / 5 h / Reflux 2.1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C 2.2: Reflux View Scheme |
3-phenyl-propionaldehyde
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: titanium tetrachloride / 2,2,2-trifluoroethanol / 7 h / 25 °C 2.1: trifluoroacetic acid / 5 h / Reflux 3.1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C 3.2: Reflux View Scheme |
benzyl (3S)-3-amino-2,3,4,5-tetrahydro-2-oxo-1H-benzazepine-1-acetate
benazepril hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: titanium tetrachloride / 2,2,2-trifluoroethanol / 7 h / 25 °C 2.1: trifluoroacetic acid / 5 h / Reflux 3.1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C 3.2: Reflux View Scheme |
benazepril hydrochloride
benazepril
Conditions | Yield |
---|---|
With potassium carbonate In Isopropyl acetate; water at 20℃; pH=4 - 5; Industry scale; |
benazepril hydrochloride
benazeprilate
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide In methanol; water | |
With sodium hydroxide for 0.5h; Reflux; |
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