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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Benazepril hydrochloride Manufacturer/High quality/Best price/In stock

Cas:86541-74-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

Introduction Benazepril hydrochloride is the main ingredient in benazepril hydrochloride tablets.The mechanism of action is that it can inhibit the activity of angiotensin-converting enzyme, which can relieve a series of symptoms caused by angiotens

High Quliaty 99% Benazepril hydrochloride 86541-74-4

Cas:86541-74-4

Min.Order:0 Metric Ton

FOB Price: $1845.0

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white crystalline powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:medicine r

Manufacturer high quality Benazepril hydrochloride Cas 86541-74-4 with good price

Cas:86541-74-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Benazepril

Cas:86541-74-4

Min.Order:1

Negotiable

Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Benazepril Hydrochloride manufacturer with low price

Cas:86541-74-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Benazepril hydrochloride 86541-74-4 GMP Manufacturer

Cas:86541-74-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Benazepril hydrochloride

Cas:86541-74-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU-CHEM--Benazepril hydrochloride

Cas:86541-74-4

Min.Order:1 Kilogram

FOB Price: $1300.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can

Benazepril hydrochloride CAS:86541-74-4

Cas:86541-74-4

Min.Order:1 Metric Ton

FOB Price: $520.0 / 888.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 86541-74-4 with fast shipping

Cas:86541-74-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Benazepril hydrochloride/ LIDE PHARMA- Factory supply / Best price

Cas:86541-74-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product Name: Benazepril hydrochloride CAS: 86541-74-4 Synonyms:1h-1-benzazepine-1-aceticacid,2,3,4,5-tetrahydro-3-((1-(ethoxycarbonyl)-3-phe;cgs14824a;monohydrochloride,(s-(r*,r*))-nylpropyl)amino)-2-oxo;BenazeprilHclC24H28N205.HC1;1H

Benazepril hydrochloride

Cas:86541-74-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Benazepril hydrochloride Molecular Structure: Formula: C24H29ClN2O5 Molecular Weight :460.95 Synonyms: 1h-1-benzazepine-1-aceticacid,2,3,4,5-tetrahydro-3-

Factory Supply Benazepril hydrochloride

Cas:86541-74-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Benazepril hydrochloride with CAS:86541-74-4

Cas:86541-74-4

Min.Order:1 Kilogram

FOB Price: $65.0 / 95.0

Type:Trading Company

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many o

Benazepril Hydrochloride CAS 86541-74-4

Cas:86541-74-4

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Benazepril hydrochloride Synonyms: 1h-1-benzazepine-1-aceticacid,2,3,4,5-tetrahydro-3-((1-(ethoxycarbonyl)-3-phe;cgs14824a;monohydrochloride,(s-(r*,r*))-nylpropyl)amino)-2-oxo;BenazeprilHclC24H28N205.HC1;1H-1-Benzazepine-1-acetic a

Benazepril hydrochloride high purity best quality

Cas:86541-74-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Benazepril hydrochloride CAS 86541-74-4 with Fast Shipment

Cas:86541-74-4

Min.Order:1 Kilogram

FOB Price: $7.0 / 32.0

Type:Trading Company

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Benazepril hydrochloride

Cas:86541-74-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Taixing Joxin Bio-tec Co.,Ltd.

(Synonyms:1h-1-benzazepine-1-aceticacid,2,3,4,5-tetrahydro-3-((1-(ethoxycarbonyl)-3-phe cgs14824a monohydrochloride,(s-(r*,r*))-nylpropyl)amino)-2-oxo BenazeprilHclC24H28N205.HC1 1H-1-Benzazepine-1-acetic acid, 3-(1S)-1-(ethoxycarbonyl)-3-pheny

Benazepril Hydrochloride

Cas:86541-74-4

Min.Order:10 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benazepril hydrochloride

Cas:86541-74-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as an antihypertensive Transportation:

Benazepril hydrochloride

Cas:86541-74-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

benazepril hydrochloride

Cas:86541-74-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Maisheng Hebei Technology Co., Ltd.

Our Advantages: 1. A strong scientific research team (40people in the research team, including 7 Doctors, 13Masters...). 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch o

Antihypertensive Angiotensin Pharmaceutical Material Benazepril HCl CAS 86541-74-4

Cas:86541-74-4

Min.Order:1 box

FOB Price: $26.0 / 30.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

Hubei Vanz Pharm Co.,Ltd

Antihypertensive API 99% Purity Bulk Benazepril Hydrochloride Benazepril HCl Powder cas 86541-74-4Name: Benazepril hydrochloride CAS: 86541-74-4 MF: C24H29ClN2O5 MW: 460.95 EINECS: 630-414-2 Melting point 188-190°C storage tem

Shanghai Minstar Chemical Co., Ltd

Benazepril hydrochloride Basic information Product Name: Benazepril hydrochloride Synonyms: 1h-1-benzazepine-1-aceticacid,2,3,4,5-tetrahydro-3-((1-(ethoxycarbonyl)-3-phe;cgs14824a;monohydrochloride,(s-(r*,r*))-nylpropyl)amino)-2-oxo;Benazepril

Benazepril hydrochloride

Cas:86541-74-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Benazepril Hydrochloride CAS No.:86541-74-4 Molecule Formula:C24H29ClN2O5 Molecule Weight:460.95 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard

High Quality Benazepril Hydrochloride

Cas:86541-74-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Synthetic route

(2S,3'S)-2-(1-tert-butoxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester
109010-61-9

(2S,3'S)-2-(1-tert-butoxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate91.6%
With hydrogenchloride In toluene at 0 - 20℃; for 1.5h;90%
With hydrogenchloride In ethyl acetate at -10 - 25℃; for 16h; Industry scale;
With hydrogenchloride In ethyl acetate at 10℃; under 760.051 Torr; Solvent; Reflux;Ca. 114 g
With hydrogenchloride In Isopropyl acetate at 10℃;99.6 g
ethyl (S)-2-(((S)-1-(2-(benzyloxy)-2-oxoethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3- yl)amino)-4-phenylbutanoate

ethyl (S)-2-(((S)-1-(2-(benzyloxy)-2-oxoethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3- yl)amino)-4-phenylbutanoate

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Stage #1: ethyl (S)-2-(((S)-1-(2-(benzyloxy)-2-oxoethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3- yl)amino)-4-phenylbutanoate With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 3h;
Stage #2: With hydrogenchloride In ethyl acetate; acetone Reflux;
91%
2-oxo-4-phenylbutanoic acid ethyl ester
64920-29-2

2-oxo-4-phenylbutanoic acid ethyl ester

(3S)-3-amino-1-(carboxymethyl)-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one sodium salt
86499-53-8

(3S)-3-amino-1-(carboxymethyl)-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one sodium salt

A

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

B

(3S)-1-(carboxymethyl)-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one hydrochloride
86541-77-7

(3S)-1-(carboxymethyl)-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one hydrochloride

Conditions
ConditionsYield
With sodium cyanoborohydride In methanol; acetic acid Ambient temperature;A 12%
B 25%
2-acetylnitrobenzene
577-59-3

2-acetylnitrobenzene

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 99 percent / sodium ethoxide / tetrahydrofuran / 2 h / 0 °C
2.1: phenacyl chloride; baker's yeast / diethyl ether; H2O / 24 h / 30 °C
3.1: H2; HCl / Pd/C / methanol / 20 °C
3.2: 42 percent / AcOH / toluene / 80 °C
4.1: Et3N / tetrahydrofuran / 16 h / 20 °C
5.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
6.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C
6.2: 98 percent / tetrahydrofuran / 5 h / 20 °C
7.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: 99 percent / sodium ethoxide / tetrahydrofuran / 2 h / 0 °C
2.1: phenacyl chloride; baker's yeast / diethyl ether; H2O / 24 h / 30 °C
3.1: NaBH4; acetic acid / 2 h / 0 °C
4.1: H2 / Pd/C / methanol / 24 h / 20 °C
4.2: H2; hydrochloric acid / Pd/C / methanol / 36 h / 20 °C
4.3: 74 percent / AcOH / toluene / 16 h / 80 °C
5.1: Et3N / tetrahydrofuran / 16 h / 20 °C
6.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
7.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C
7.2: 98 percent / tetrahydrofuran / 5 h / 20 °C
8.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C
View Scheme
4-(2-nitrophenyl)-2,4-dioxobutanoic acid ethyl ester
178114-28-8

4-(2-nitrophenyl)-2,4-dioxobutanoic acid ethyl ester

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: phenacyl chloride; baker's yeast / diethyl ether; H2O / 24 h / 30 °C
2.1: H2; HCl / Pd/C / methanol / 20 °C
2.2: 42 percent / AcOH / toluene / 80 °C
3.1: Et3N / tetrahydrofuran / 16 h / 20 °C
4.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
5.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C
5.2: 98 percent / tetrahydrofuran / 5 h / 20 °C
6.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: phenacyl chloride; baker's yeast / diethyl ether; H2O / 24 h / 30 °C
2.1: NaBH4; acetic acid / 2 h / 0 °C
3.1: H2 / Pd/C / methanol / 24 h / 20 °C
3.2: H2; hydrochloric acid / Pd/C / methanol / 36 h / 20 °C
3.3: 74 percent / AcOH / toluene / 16 h / 80 °C
4.1: Et3N / tetrahydrofuran / 16 h / 20 °C
5.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
6.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C
6.2: 98 percent / tetrahydrofuran / 5 h / 20 °C
7.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C
View Scheme
ethyl 2-amino-4-phenyl-(2S)-butyrate
46460-23-5

ethyl 2-amino-4-phenyl-(2S)-butyrate

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
2.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C
2.2: 98 percent / tetrahydrofuran / 5 h / 20 °C
3.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C
View Scheme
(3R)-3-hydroxy-1,3,4,5-tetrahydrobenzo[b]azepin-2-one
608148-60-3

(3R)-3-hydroxy-1,3,4,5-tetrahydrobenzo[b]azepin-2-one

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Et3N / tetrahydrofuran / 16 h / 20 °C
2.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
3.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C
3.2: 98 percent / tetrahydrofuran / 5 h / 20 °C
4.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C
View Scheme
(2R)-2-hydroxy-4-(2-nitrophenyl)-4-oxobutyric acid ethyl ester
608148-58-9

(2R)-2-hydroxy-4-(2-nitrophenyl)-4-oxobutyric acid ethyl ester

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: H2; HCl / Pd/C / methanol / 20 °C
1.2: 42 percent / AcOH / toluene / 80 °C
2.1: Et3N / tetrahydrofuran / 16 h / 20 °C
3.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
4.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C
4.2: 98 percent / tetrahydrofuran / 5 h / 20 °C
5.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: NaBH4; acetic acid / 2 h / 0 °C
2.1: H2 / Pd/C / methanol / 24 h / 20 °C
2.2: H2; hydrochloric acid / Pd/C / methanol / 36 h / 20 °C
2.3: 74 percent / AcOH / toluene / 16 h / 80 °C
3.1: Et3N / tetrahydrofuran / 16 h / 20 °C
4.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
5.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C
5.2: 98 percent / tetrahydrofuran / 5 h / 20 °C
6.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C
View Scheme
(R)-2,4-Dihydroxy-4-(2-nitro-phenyl)-butyric acid ethyl ester
656830-87-4

(R)-2,4-Dihydroxy-4-(2-nitro-phenyl)-butyric acid ethyl ester

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: H2 / Pd/C / methanol / 24 h / 20 °C
1.2: H2; hydrochloric acid / Pd/C / methanol / 36 h / 20 °C
1.3: 74 percent / AcOH / toluene / 16 h / 80 °C
2.1: Et3N / tetrahydrofuran / 16 h / 20 °C
3.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
4.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C
4.2: 98 percent / tetrahydrofuran / 5 h / 20 °C
5.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C
View Scheme
4-(2-nitro-phenyl)-2,4-dioxo-butyric acid butyl ester

4-(2-nitro-phenyl)-2,4-dioxo-butyric acid butyl ester

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: phenacyl chloride; baker's yeast / diethyl ether; H2O / 24 h / 30 °C
1.2: H2; hydrochloric acid / Pd/C / methanol / 20 °C
1.3: AcOH / toluene / 80 °C
2.1: Et3N / tetrahydrofuran / 16 h / 20 °C
3.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
4.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C
4.2: 98 percent / tetrahydrofuran / 5 h / 20 °C
5.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C
View Scheme
4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester
608148-63-6

4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
2.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C
2.2: 98 percent / tetrahydrofuran / 5 h / 20 °C
3.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C
View Scheme
(2S,3'S)-2-(2'-oxo-2',3',4',5'-tetrahydro-1H-benzo[b]azepin-3'-ylamino)-4-phenylbutyric acid ethyl ester
367909-45-3

(2S,3'S)-2-(2'-oxo-2',3',4',5'-tetrahydro-1H-benzo[b]azepin-3'-ylamino)-4-phenylbutyric acid ethyl ester

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C
1.2: 98 percent / tetrahydrofuran / 5 h / 20 °C
2.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C
View Scheme
2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one
4424-80-0

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 90 percent / PCl5 / xylene / 0.5 h / 90 °C
2: 95 percent / H2, sodium acetate / 5percent Pd/C / acetic acid / 0.5 h / 760 Torr / Ambient temperature
3: 90 percent / sodium azide / dimethylsulfoxide / 3 h / 80 °C
4: 96 percent / Bu4NBr, KOH / tetrahydrofuran / 1.5 h / Ambient temperature
5: 93 percent / H2 / 10percent Pd/C / ethanol / 1.5 h / 2280 Torr / Ambient temperature
7: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature
8: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature
View Scheme
3,3-dichloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one
86499-22-1

3,3-dichloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 95 percent / H2, sodium acetate / 5percent Pd/C / acetic acid / 0.5 h / 760 Torr / Ambient temperature
2: 90 percent / sodium azide / dimethylsulfoxide / 3 h / 80 °C
3: 96 percent / Bu4NBr, KOH / tetrahydrofuran / 1.5 h / Ambient temperature
4: 93 percent / H2 / 10percent Pd/C / ethanol / 1.5 h / 2280 Torr / Ambient temperature
6: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature
7: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature
View Scheme
3-chloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one
86499-23-2

3-chloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 90 percent / sodium azide / dimethylsulfoxide / 3 h / 80 °C
2: 96 percent / Bu4NBr, KOH / tetrahydrofuran / 1.5 h / Ambient temperature
3: 93 percent / H2 / 10percent Pd/C / ethanol / 1.5 h / 2280 Torr / Ambient temperature
5: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature
6: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature
View Scheme
3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine
97278-68-7

3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 96 percent / Bu4NBr, KOH / tetrahydrofuran / 1.5 h / Ambient temperature
2: 93 percent / H2 / 10percent Pd/C / ethanol / 1.5 h / 2280 Torr / Ambient temperature
4: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature
5: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature
View Scheme
ethyl 3-azido-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one-1-acetate
92278-69-8

ethyl 3-azido-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one-1-acetate

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / H2 / 10percent Pd/C / ethanol / 1.5 h / 2280 Torr / Ambient temperature
3: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature
4: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature
View Scheme
3-(S)-amino-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one
94793-89-2

3-(S)-amino-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature
3: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature
View Scheme
(S)-3-amino-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one
86499-52-7

(S)-3-amino-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature
2: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature
View Scheme
3-[[1-(t-butoxy-carbonyl)-3-phenyl-(1S)-propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic acid ethyl ester
859635-53-3

3-[[1-(t-butoxy-carbonyl)-3-phenyl-(1S)-propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic acid ethyl ester

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate at 0℃; for 2 - 3h;
benazepril
86541-75-5

benazepril

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Stage #1: benazepril With Celite; pyrographite In acetone for 1h; Heating / reflux; Industry scale;
Stage #2: With hydrogenchloride In water; acetone at 10 - 50℃; for 3h;
2-oxo-4-phenylbutanoic acid ethyl ester
64920-29-2

2-oxo-4-phenylbutanoic acid ethyl ester

(3S)-3-amino-1-(carboxymethyl)-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one sodium salt
86499-53-8

(3S)-3-amino-1-(carboxymethyl)-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one sodium salt

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; sodium cyanoborohydride In methanol; dichloromethane; acetic acid; butanone
With hydrogenchloride; sodium cyanoborohydride In methanol; dichloromethane; acetic acid; butanone
ethyl (R)-2-hydroxy-4-phenylbutyrate
90315-82-5

ethyl (R)-2-hydroxy-4-phenylbutyrate

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / ethyl acetate / 3 h / 0 - 25 °C
2: sodium carbonate / ethyl acetate / 20 h / 80 °C / 760.05 Torr
3: hydrogenchloride / ethyl acetate / 10 °C / 760.05 Torr / Reflux
View Scheme
3-bromo-2,3,4,5-tetrahydro-1H-[1]-benzoazepine-2-one-1-acetic acid tert-butyl ester

3-bromo-2,3,4,5-tetrahydro-1H-[1]-benzoazepine-2-one-1-acetic acid tert-butyl ester

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / methanol / 24 h / 60 °C
2.1: 1,1'-carbonyldiimidazole / Isopropyl acetate / 4 h / 20 °C
2.2: 4 h
3.1: hydrogenchloride / Isopropyl acetate / 10 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / isopropyl alcohol / 24 h / 60 °C
2.1: 1,1'-carbonyldiimidazole / Isopropyl acetate / 4 h / 20 °C
2.2: 4 h
3.1: hydrogenchloride / Isopropyl acetate / 10 °C
View Scheme
D-homophenylalanine
943-73-7

D-homophenylalanine

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / methanol / 24 h / 60 °C
2.1: 1,1'-carbonyldiimidazole / Isopropyl acetate / 4 h / 20 °C
2.2: 4 h
3.1: hydrogenchloride / Isopropyl acetate / 10 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / isopropyl alcohol / 24 h / 60 °C
2.1: 1,1'-carbonyldiimidazole / Isopropyl acetate / 4 h / 20 °C
2.2: 4 h
3.1: hydrogenchloride / Isopropyl acetate / 10 °C
View Scheme
benzyl 2-((S)-3-(((S)-1-((2-nitrobenzyl) amino)-1-oxo-4-phenylbutan-2-yl) amino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetate

benzyl 2-((S)-3-(((S)-1-((2-nitrobenzyl) amino)-1-oxo-4-phenylbutan-2-yl) amino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetate

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / 5 h / Reflux
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C
2.2: Reflux
View Scheme
3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: titanium tetrachloride / 2,2,2-trifluoroethanol / 7 h / 25 °C
2.1: trifluoroacetic acid / 5 h / Reflux
3.1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C
3.2: Reflux
View Scheme
benzyl (3S)-3-amino-2,3,4,5-tetrahydro-2-oxo-1H-benzazepine-1-acetate
183508-58-9

benzyl (3S)-3-amino-2,3,4,5-tetrahydro-2-oxo-1H-benzazepine-1-acetate

benazepril hydrochloride
86541-74-4

benazepril hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: titanium tetrachloride / 2,2,2-trifluoroethanol / 7 h / 25 °C
2.1: trifluoroacetic acid / 5 h / Reflux
3.1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C
3.2: Reflux
View Scheme
benazepril hydrochloride
86541-74-4

benazepril hydrochloride

benazepril
86541-75-5

benazepril

Conditions
ConditionsYield
With potassium carbonate In Isopropyl acetate; water at 20℃; pH=4 - 5; Industry scale;
benazepril hydrochloride
86541-74-4

benazepril hydrochloride

benazeprilate
86541-78-8

benazeprilate

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In methanol; water
With sodium hydroxide for 0.5h; Reflux;

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