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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 868539-96-2 with competitive price

Cas:868539-96-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Carfilzomi Intermediate Boc-Hph-Leu-Phe-Ome CAS: 868539-96-2

Cas:868539-96-2

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Boc-HPh-Leu-Phe-OMe

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: BOC-Hph-Leu-Phe-Ome CAS No.:868539-96-2 Molecule Formula:C31H43N3O6 Molecule Weight:553.69 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality BOC-Hph-Leu-Phe-Ome in stock

Cas:868539-96-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Boc-HPh-Leu-Phe-Ome

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Trading Company

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Boc-HPh-Leu-Phe-OMe

Cas:868539-96-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

Boc-HPh-Leu-Phe-OMe

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Kilograms/MT Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

Boc-HPh-Leu-Phe-OMe

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

Boc-HPh-Leu-Phe-OMe

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

Boc-HPh-Leu-Phe-OMe

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Boc-HPh-Leu-Phe-OMe

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

868539-96-2

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Terui OP New Material Technology Co., Ltd.

The factory supplies Application:manufacturing supplies

Boc-HPh-Leu-Phe-OMe

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Trading Company

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Boc-HPh-Leu-Phe-OMe

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Trading Company

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Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

(6S,9S,12S)-Methyl 12-benzyl-9-isobutyl-2,2-dimethyl-4,7,10-trioxo-6-phenethyl-3-oxa-5,8,11-triazatridecan-13-oate

Cas:868539-96-2

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Zhengzhou Kingorgchem Chemical Technology Co., Ltd.

1. Subsidiary of Institute of Chemistry, Henan Academy of Sciences, national research platform;2. About 30 years’ experience in this field since 1983;3. An experienced R&D team consisting of Doctors and Masters;4. Various types of analytical instrume

ISO 9001 National Research Platform CAS No. 868539-96-2

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Toda Biotechnology Co., Limited.

Todachem specialize in exporting chemicals for 10 years, we manufacture and distribute high quality pharmaceutical APIs, intermediates, special chemicals, active molecule and other fine chemicals. We have our research laboratory and more than 100 n

Shanghai Yingrui Biopharma Co., Ltd

1. factory price 2. high purity 3.DMF files 4. in stock 5. good service 6. we also provide the custom synthesis service 7. fast delivery SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. was established in 2009 ,is a research and developmen

Boc-HPh-Leu-Phe-Ome 868539-96-2

Cas:868539-96-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Sunsure Chemical Technology Co., Ltd

Nanjing Sunsure Chemical Technology Co., Ltd., established in 2009, has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. Sunsure covers whole

Boc-HPh-Leu-Phe-OMe 868539-96-2 supplier

Cas:868539-96-2

Min.Order:1 Milligram

Negotiable

Type:Lab/Research institutions

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ShenZhen InnoSyn Biotech Co.,Ltd

Produce in South China, less pressure in environment protection, more stable production.Honored as "National Hi-tech Enterprise" & "Shenzhen Hi-tech Enterprise";4000+m2 R&D center & 47,000m2 plant, 20 R&D technicians, tens of reactors from 100L to 50

Boc-HPh-Leu-Phe-OMe

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Trading Company

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coolpharm Ltd

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Appearance:yellow to white solid Storage:keep sealed and keep from direct light Package:According client's requirements Application:Phar

Boc-HPh-Leu-Phe-Ome

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Other

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Cjioo(Shanghai) biotechnology co., LTD

In stock ,If you need HNMR\HPLC,please contact us!excellent quality and reasonable price and absolutely worthy. Storage:in stock Application:Pharmaceutical Intermediate Transportation:By air or By sea or By express

Boc-HPh-Leu-Phe-OMe

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shenzhen Sumshine Biotech Co., Ltd.

1. Our staff are all biomedical related majors with rich experience in the pharmaceutical industry, and can provide you with more professional services.2. Our supplier has a good quality management system, and the quality of products is reliable and

Carfilzomib Impurity 70

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Alchemist-pharm chemical Technology Co. Ltd.

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

868539-96-2

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

NovaChemistry

high purity Application:Drug intermediates Materials intermediates and active molecules

Boc-HPh-Leu-Phe-OMe

Cas:868539-96-2

Min.Order:0

Negotiable

Type:Trading Company

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Synthetic route

Leu-Phe-OMe trifluoroacetate

Leu-Phe-OMe trifluoroacetate

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 0 - 20℃;
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h;
N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

L-leucyl-L-phenylalanine methyl ester
38155-18-9

L-leucyl-L-phenylalanine methyl ester

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;
N-tert-butoxycarbonyl-L-leucine
13139-15-6

N-tert-butoxycarbonyl-L-leucine

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
2: trifluoroacetic acid / dichloromethane / 3 h
3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
2: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C
3: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
2: trifluoroacetic acid / dichloromethane
View Scheme
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
7524-50-7

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
2: trifluoroacetic acid / dichloromethane / 3 h
3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
2: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C
3: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
View Scheme
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester
15136-32-0, 87976-66-7, 120342-25-8, 5874-73-7

(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 3 h
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane / 3 h / 0 - 20 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
View Scheme
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester
15136-32-0, 87976-66-7, 120342-25-8, 5874-73-7

(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
Stage #1: (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 2h;
Stage #2: Boc-L-homophenylalanine With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;
21.59 g
Stage #1: (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester With trifluoroacetic acid In dichloromethane
Stage #2: Boc-L-homophenylalanine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane
246 mg
methyl (2S)-2-amino-3-phenylpropanoate
2577-90-4

methyl (2S)-2-amino-3-phenylpropanoate

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
2: dichloromethane / 3 h / 0 - 20 °C
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
View Scheme
(S)-methyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate hydrochloride
6461-07-0

(S)-methyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate hydrochloride

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 0 - 30℃; for 2h; Inert atmosphere;121.0 g
L-leucine
61-90-5

L-leucine

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / water / 20 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
3: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C
4: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
View Scheme
L-phenylalanine
63-91-2

L-phenylalanine

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / 8 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
3: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C
4: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
View Scheme
N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / 2 h / 0 - 20 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
3: dichloromethane / 3 h / 0 - 20 °C
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

trifluoroacetic acid
76-05-1

trifluoroacetic acid

C2HF3O2*C26H35N3O4
868539-99-5

C2HF3O2*C26H35N3O4

Conditions
ConditionsYield
In dichloromethane at 20℃; for 1h; Product distribution / selectivity;
In dichloromethane at 0 - 20℃; for 3h;
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

C44H61N7O8
1545469-05-3

C44H61N7O8

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
3: dichloromethane / 4 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

C39H50N6O6
1545468-61-8

C39H50N6O6

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
3: dichloromethane / 4 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

C36H49N4O10P(2-)*2Na(1+)

C36H49N4O10P(2-)*2Na(1+)

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
3: dichloromethane / 4 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; water / 2 h / 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

C38H50N6O6S
1545468-62-9

C38H50N6O6S

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
3: dichloromethane / 4 h / 20 °C
4: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

C39H53N7O6
1545468-63-0

C39H53N7O6

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
3: dichloromethane / 4 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
5: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

C39H52N6O6S
1545468-64-1

C39H52N6O6S

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
3: dichloromethane / 4 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

C30H41N3O6

C30H41N3O6

Conditions
ConditionsYield
With lithium hydroxide monohydrate In tetrahydrofuran; methanol at 0 - 20℃; for 3h;
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

C39H56N4O7

C39H56N4O7

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: hydrazine / methanol / Reflux
2.1: hydrogenchloride; tert-butyl nitrate / 1,4-dioxane; N,N-dimethyl-formamide / 0.17 h / -30 °C / Inert atmosphere
2.2: -30 - 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

(S)-2-((S)-2-amino-4-phenylbutanamido)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pentanamide 2,2,2-trifluoroacetate

(S)-2-((S)-2-amino-4-phenylbutanamido)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pentanamide 2,2,2-trifluoroacetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
3: dichloromethane / 4 h / 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

C50H63N4O10P

C50H63N4O10P

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
3: dichloromethane / 4 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

chloroacetyl chloride
79-04-9

chloroacetyl chloride

C28H36ClN3O5
868540-08-3

C28H36ClN3O5

Conditions
ConditionsYield
Stage #1: (S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate With trifluoroacetic acid In dichloromethane at 20℃; for 1h;
Stage #2: chloroacetyl chloride With N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;
0.64 g
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

(x)C6H8O7*C40H57N5O7

(x)C6H8O7*C40H57N5O7

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
1.2: 0 - 20 °C / Inert atmosphere
2.1: potassium iodide / tetrahydrofuran / Inert atmosphere
3.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C
4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 1 h / 0 °C
5.1: tetrahydrofuran; acetonitrile / 2 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
1.2: 0 - 20 °C / Inert atmosphere
2.1: potassium iodide / tetrahydrofuran / Inert atmosphere
3.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C
4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 0 - 5 °C
5.1: tetrahydrofuran; acetonitrile / 2 h / 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

C32H44N4O6

C32H44N4O6

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
1.2: 0 - 20 °C / Inert atmosphere
2.1: potassium iodide / tetrahydrofuran / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane / 3 h / 0 - 20 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
1.2: 0 - 20 °C / Inert atmosphere
2.1: potassium iodide / tetrahydrofuran / Inert atmosphere
3.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
3: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1: dichloromethane / 3 h / 0 - 20 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
3: lithium hydroxide monohydrate / methanol / 3 h / 0 - 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

carfilzomib

carfilzomib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
1.2: 0 - 20 °C / Inert atmosphere
2.1: potassium iodide / tetrahydrofuran / Inert atmosphere
3.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C
4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 1 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
1.2: 0 - 20 °C / Inert atmosphere
2.1: potassium iodide / tetrahydrofuran / Inert atmosphere
3.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C
4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 0 - 5 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
3: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
4: benzotriazol-1-ol; 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 3 h / 0 - 5 °C / Inert atmosphere
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

Reaxys ID: 30386849

Reaxys ID: 30386849

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
3: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

(S)-methyl 2-((S)-2-((S)-2-amino-4-phenyIbutanamido)-4-methylpentanamido)-3-phenylpropanoate hydrochloride

(S)-methyl 2-((S)-2-((S)-2-amino-4-phenyIbutanamido)-4-methylpentanamido)-3-phenylpropanoate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate at 25 - 30℃; for 2h;75.2 g
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

(S)-perfluorophenyl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoate

(S)-perfluorophenyl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
3: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
4: 4-methyl-morpholine; HATU / dichloromethane / 6 h / 0 - 5 °C / Inert atmosphere
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

(S)-2,5-dioxopyrrolidin-1-yl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoate

(S)-2,5-dioxopyrrolidin-1-yl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
3: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
4: diisopropyl-carbodiimide / dichloromethane / 6 h / 0 - 30 °C / Inert atmosphere
View Scheme

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