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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product name: BOC-Hph-Leu-Phe-Ome CAS No.:868539-96-2 Molecule Formula:C31H43N3O6 Molecule Weight:553.69 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS
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inquiryHangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
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inquiryJ&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
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1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
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inquiry1. Subsidiary of Institute of Chemistry, Henan Academy of Sciences, national research platform;2. About 30 years’ experience in this field since 1983;3. An experienced R&D team consisting of Doctors and Masters;4. Various types of analytical instrume
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inquiry1. factory price 2. high purity 3.DMF files 4. in stock 5. good service 6. we also provide the custom synthesis service 7. fast delivery SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. was established in 2009 ,is a research and developmen
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inquiryNanjing Sunsure Chemical Technology Co., Ltd., established in 2009, has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. Sunsure covers whole
Cas:868539-96-2
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inquiryProduce in South China, less pressure in environment protection, more stable production.Honored as "National Hi-tech Enterprise" & "Shenzhen Hi-tech Enterprise";4000+m2 R&D center & 47,000m2 plant, 20 R&D technicians, tens of reactors from 100L to 50
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R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
high purity Application:Drug intermediates Materials intermediates and active molecules
Boc-L-homophenylalanine
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 0 - 20℃; | |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h; |
N-tert-butoxycarbonyl-L-phenylalanine
L-leucyl-L-phenylalanine methyl ester
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; |
N-tert-butoxycarbonyl-L-leucine
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 2: trifluoroacetic acid / dichloromethane / 3 h 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C 2.2: 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere 2: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C 3: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C 2: trifluoroacetic acid / dichloromethane View Scheme |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 2: trifluoroacetic acid / dichloromethane / 3 h 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere 2: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C 3: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere View Scheme |
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trifluoroacetic acid / dichloromethane / 3 h 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C 2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: dichloromethane / 3 h / 0 - 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C View Scheme |
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester
Boc-L-homophenylalanine
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Stage #1: (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 2h; Stage #2: Boc-L-homophenylalanine With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere; | 21.59 g |
Stage #1: (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester With trifluoroacetic acid In dichloromethane Stage #2: Boc-L-homophenylalanine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane | 246 mg |
methyl (2S)-2-amino-3-phenylpropanoate
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C 2.2: 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C 2: dichloromethane / 3 h / 0 - 20 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C View Scheme |
Boc-L-homophenylalanine
(S)-methyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate hydrochloride
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 0 - 30℃; for 2h; Inert atmosphere; | 121.0 g |
L-leucine
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide / water / 20 h / 25 - 30 °C 2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere 3: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C 4: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere View Scheme |
L-phenylalanine
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / 8 h / 25 - 30 °C 2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere 3: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C 4: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere View Scheme |
N-tert-butoxycarbonyl-L-phenylalanine
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / 2 h / 0 - 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C 3: dichloromethane / 3 h / 0 - 20 °C 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
trifluoroacetic acid
C2HF3O2*C26H35N3O4
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 1h; Product distribution / selectivity; | |
In dichloromethane at 0 - 20℃; for 3h; |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
C44H61N7O8
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: dichloromethane / 4 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
C39H50N6O6
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: dichloromethane / 4 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: dichloromethane / 4 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; water / 2 h / 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
C38H50N6O6S
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: dichloromethane / 4 h / 20 °C 4: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
C39H53N7O6
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: dichloromethane / 4 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 5: trifluoroacetic acid / dichloromethane / 3 h / 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
C39H52N6O6S
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: dichloromethane / 4 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
With lithium hydroxide monohydrate In tetrahydrofuran; methanol at 0 - 20℃; for 3h; |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: hydrazine / methanol / Reflux 2.1: hydrogenchloride; tert-butyl nitrate / 1,4-dioxane; N,N-dimethyl-formamide / 0.17 h / -30 °C / Inert atmosphere 2.2: -30 - 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: dichloromethane / 4 h / 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: dichloromethane / 4 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
chloroacetyl chloride
C28H36ClN3O5
Conditions | Yield |
---|---|
Stage #1: (S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate With trifluoroacetic acid In dichloromethane at 20℃; for 1h; Stage #2: chloroacetyl chloride With N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere; | 0.64 g |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 1.2: 0 - 20 °C / Inert atmosphere 2.1: potassium iodide / tetrahydrofuran / Inert atmosphere 3.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C 4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 1 h / 0 °C 5.1: tetrahydrofuran; acetonitrile / 2 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 1.2: 0 - 20 °C / Inert atmosphere 2.1: potassium iodide / tetrahydrofuran / Inert atmosphere 3.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C 4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 0 - 5 °C 5.1: tetrahydrofuran; acetonitrile / 2 h / 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 1.2: 0 - 20 °C / Inert atmosphere 2.1: potassium iodide / tetrahydrofuran / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C 2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: dichloromethane / 3 h / 0 - 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 1.2: 0 - 20 °C / Inert atmosphere 2.1: potassium iodide / tetrahydrofuran / Inert atmosphere 3.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C 2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere 3: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1: dichloromethane / 3 h / 0 - 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C 3: lithium hydroxide monohydrate / methanol / 3 h / 0 - 20 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 1.2: 0 - 20 °C / Inert atmosphere 2.1: potassium iodide / tetrahydrofuran / Inert atmosphere 3.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C 4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 1 h / 0 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 1.2: 0 - 20 °C / Inert atmosphere 2.1: potassium iodide / tetrahydrofuran / Inert atmosphere 3.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C 4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C 2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere 3: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C 4: benzotriazol-1-ol; 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 3 h / 0 - 5 °C / Inert atmosphere View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C 2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere 3: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate at 25 - 30℃; for 2h; | 75.2 g |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C 2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere 3: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C 4: 4-methyl-morpholine; HATU / dichloromethane / 6 h / 0 - 5 °C / Inert atmosphere View Scheme |
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C 2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere 3: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C 4: diisopropyl-carbodiimide / dichloromethane / 6 h / 0 - 30 °C / Inert atmosphere View Scheme |
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