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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-L-phenylalanine

Cas:868540-16-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Hangzhou Think Chemical Co. Ltd

(alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-L-phenylalanine CAS No.:868540-16-3 Name: (alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-L-phenyla

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial since 1987 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We can do dif

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(S)-2-{(S)-4-methyl-2-[(S)-2-(2-morpholinoacetamido)-4-phenylbutanamido]-pentanamido}-3-phenylpropanoic acid

Cas:868540-16-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

(alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-L-phenylalanine

Cas:868540-16-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C31H42N4O6 (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine 868540-16-3

Cas:868540-16-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 868540-16-3 with competitive price

Cas:868540-16-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine CAS NO.868540-16-3

Cas:868540-16-3

Min.Order:10 Kilogram

FOB Price: $180.0 / 200.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine 868540-16-3

Cas:868540-16-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine CAS:868540-16-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of c

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine CAS:868540-16-3

Cas:868540-16-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine

Cas:868540-16-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine

Cas:868540-16-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Carfilzomib intermediate 2 Transportation:By Sea/Air/Courier Po

(alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-L-phenylalanine

Cas:868540-16-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine

Cas:868540-16-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:20

Saiwante (shanghai) New Material Technology Co., Ltd.

ProName: (alphaS)-alpha-[(4-Morpholinylacetyl)a... CasNo: 868540-16-3 Molecular Formula: C31H42N4O6 Appearance: detailed see specifications Application: An important raw material and intermed... DeliveryTime: prompt PackAge: according to the

(alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-L-phenylalanine CAS NO.868540-16-3

Cas:868540-16-3

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scientists co

(alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-L-phenylalanine

Cas:868540-16-3

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine

Cas:868540-16-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Carfilzomib Intermediates I CAS No.:868540-16-3 Molecule Formula:C31H42N4O6 Molecule Weight:566.68 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTIN

High Quality Carfilzomib Intermediates I in stock

Cas:868540-16-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine6-3

Cas:868540-16-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine CAS NO.868540-16-3

Cas:868540-16-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine

Cas:868540-16-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine CAS NO.868540-16-3

Cas:868540-16-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

Carfilzomib intermediate

Cas:868540-16-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine CAS NO.868540-16-3

Cas:868540-16-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:shenzhen/shanghai

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine

Cas:868540-16-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(S)-benzyl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamido)-3-phenylpropanoate
875309-92-5

(S)-benzyl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamido)-3-phenylpropanoate

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
With methanol; hydrogen; palladium 10% on activated carbon In ethyl acetate under 760.051 Torr; for 2h;
With palladium on activated charcoal; ammonium formate In methanol at 25 - 30℃; for 2h; Solvent; Reagent/catalyst;77 g
With 5 mol% Pd/C; hydrogen In methanol for 0.5h;
N-tert-butoxycarbonyl-L-leucine
13139-15-6

N-tert-butoxycarbonyl-L-leucine

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
2.2: 0 - 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3.2: 0 - 20 °C / Inert atmosphere
4.1: potassium iodide / tetrahydrofuran / Inert atmosphere
5.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C
View Scheme
Multi-step reaction with 6 steps
1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
2: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C
3: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
4: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
5: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
6: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: benzotriazol-1-ol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 - 30 °C
2.1: trifluoroacetic acid / dichloromethane / 2 h / 2 - 30 °C
2.2: 2 - 30 °C
3.1: trifluoroacetic acid / dichloromethane / 2 h / 2 - 30 °C
3.2: 2 - 30 °C
4.1: ammonium formate; palladium on activated charcoal / methanol / 2 h / 25 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1.1: benzotriazol-1-ol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 - 30 °C
2.1: dichloromethane / 2 h / 0 - 30 °C
3.1: benzotriazol-1-ol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 30 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 2 h / 2 - 30 °C
4.2: 2 - 30 °C
5.1: ammonium formate; palladium on activated charcoal / methanol / 2 h / 25 - 30 °C
View Scheme
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
2: dichloromethane / 1 h / 20 °C
3: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
4: dichloromethane / 1 h / 20 °C
5: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
6: 5 mol% Pd/C; hydrogen / methanol / 0.5 h
View Scheme
methyl (2S)-2-amino-3-phenylpropanoate
2577-90-4

methyl (2S)-2-amino-3-phenylpropanoate

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
2.2: 0 - 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3.2: 0 - 20 °C / Inert atmosphere
4.1: potassium iodide / tetrahydrofuran / Inert atmosphere
5.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C
View Scheme
Multi-step reaction with 6 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
2: dichloromethane / 3 h / 0 - 20 °C
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
4: dichloromethane / 3 h / 0 - 20 °C
5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
6: lithium hydroxide monohydrate / methanol / 3 h / 0 - 20 °C
View Scheme
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester
15136-32-0, 87976-66-7, 120342-25-8, 5874-73-7

(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
1.2: 0 - 20 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
2.2: 0 - 20 °C / Inert atmosphere
3.1: potassium iodide / tetrahydrofuran / Inert atmosphere
4.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C
View Scheme
Multi-step reaction with 5 steps
1: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
3: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
4: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
5: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1: dichloromethane / 3 h / 0 - 20 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
3: dichloromethane / 3 h / 0 - 20 °C
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
5: lithium hydroxide monohydrate / methanol / 3 h / 0 - 20 °C
View Scheme
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate
868539-96-2

(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
1.2: 0 - 20 °C / Inert atmosphere
2.1: potassium iodide / tetrahydrofuran / Inert atmosphere
3.1: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
3: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1: dichloromethane / 3 h / 0 - 20 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
3: lithium hydroxide monohydrate / methanol / 3 h / 0 - 20 °C
View Scheme
C28H36ClN3O5
868540-08-3

C28H36ClN3O5

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium iodide / tetrahydrofuran / Inert atmosphere
2: lithium hydroxide / methanol; water / 12 h / 0 - 5 °C
View Scheme
C32H44N4O6

C32H44N4O6

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
With lithium hydroxide In methanol; water at 0 - 5℃; for 12h;
With lithium hydroxide monohydrate; water In tetrahydrofuran at 25 - 30℃; for 3h;48.0 g
With lithium hydroxide monohydrate In methanol at 0 - 20℃; for 3h;
(S)-methyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate hydrochloride
6461-07-0

(S)-methyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate hydrochloride

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
2: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
3: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
4: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
View Scheme
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
2: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
3: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
4: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
View Scheme
(S)-methyl 2-((S)-2-((S)-2-amino-4-phenyIbutanamido)-4-methylpentanamido)-3-phenylpropanoate hydrochloride

(S)-methyl 2-((S)-2-((S)-2-amino-4-phenyIbutanamido)-4-methylpentanamido)-3-phenylpropanoate hydrochloride

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
2: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
View Scheme
L-leucine
61-90-5

L-leucine

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: sodium hydroxide / water / 20 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
3: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C
4: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
5: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
6: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
7: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
View Scheme
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
7524-50-7

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
2: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C
3: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
4: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
5: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
6: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
View Scheme
L-phenylalanine
63-91-2

L-phenylalanine

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: thionyl chloride / 8 h / 25 - 30 °C
2: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
3: hydrogenchloride / isopropyl alcohol / 2 h / 25 - 30 °C
4: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
5: hydrogenchloride / ethyl acetate / 2 h / 25 - 30 °C
6: benzotriazol-1-ol; 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 0 - 30 °C / Inert atmosphere
7: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 25 - 30 °C
View Scheme
(x)C2HF3O2*C22H28N2O3

(x)C2HF3O2*C22H28N2O3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: benzotriazol-1-ol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 30 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 2 h / 2 - 30 °C
2.2: 2 - 30 °C
3.1: ammonium formate; palladium on activated charcoal / methanol / 2 h / 25 - 30 °C
View Scheme
L-phenylalanine benzyl ester hydrochloride
2462-32-0

L-phenylalanine benzyl ester hydrochloride

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: benzotriazol-1-ol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 - 30 °C
2.1: trifluoroacetic acid / dichloromethane / 2 h / 2 - 30 °C
2.2: 2 - 30 °C
3.1: trifluoroacetic acid / dichloromethane / 2 h / 2 - 30 °C
3.2: 2 - 30 °C
4.1: ammonium formate; palladium on activated charcoal / methanol / 2 h / 25 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1.1: benzotriazol-1-ol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 - 30 °C
2.1: dichloromethane / 2 h / 0 - 30 °C
3.1: benzotriazol-1-ol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 30 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 2 h / 2 - 30 °C
4.2: 2 - 30 °C
5.1: ammonium formate; palladium on activated charcoal / methanol / 2 h / 25 - 30 °C
View Scheme
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
2: dichloromethane / 1 h / 20 °C
3: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
4: dichloromethane / 1 h / 20 °C
5: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
6: 5 mol% Pd/C; hydrogen / methanol / 0.5 h
View Scheme
(S)-benzyl 2-((S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido)-3-phenylpropanoate
140834-91-9, 70637-26-2

(S)-benzyl 2-((S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido)-3-phenylpropanoate

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / dichloromethane / 2 h / 2 - 30 °C
1.2: 2 - 30 °C
2.1: trifluoroacetic acid / dichloromethane / 2 h / 2 - 30 °C
2.2: 2 - 30 °C
3.1: ammonium formate; palladium on activated charcoal / methanol / 2 h / 25 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: dichloromethane / 2 h / 0 - 30 °C
2.1: benzotriazol-1-ol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 30 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 2 h / 2 - 30 °C
3.2: 2 - 30 °C
4.1: ammonium formate; palladium on activated charcoal / methanol / 2 h / 25 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1: dichloromethane / 1 h / 20 °C
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
3: dichloromethane / 1 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
5: 5 mol% Pd/C; hydrogen / methanol / 0.5 h
View Scheme
morpholin-4-ylacetic acid
3235-69-6

morpholin-4-ylacetic acid

Fmoc-phenylalanine-2-chlorotrityl resin

Fmoc-phenylalanine-2-chlorotrityl resin

Fmoc-Leu-OH
35661-60-0

Fmoc-Leu-OH

N-(fluorenyl-9-methoxycarbonyl)-L-homophenylalanine
132684-59-4

N-(fluorenyl-9-methoxycarbonyl)-L-homophenylalanine

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Stage #1: Fmoc-phenylalanine-2-chlorotrityl resin With piperidine In N,N-dimethyl-formamide solid-phase peptide synthesis;
Stage #2: Fmoc-Leu-OH With O‑(6‑chlorobezotriazol‑1‑yl)‑N,N,N,N‑tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide solid-phase peptide synthesis;
Stage #3: morpholin-4-ylacetic acid; N-(fluorenyl-9-methoxycarbonyl)-L-homophenylalanine Further stages;
(S)-benzyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate TFA salt
70637-28-4

(S)-benzyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate TFA salt

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
2: dichloromethane / 1 h / 20 °C
3: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
4: 5 mol% Pd/C; hydrogen / methanol / 0.5 h
View Scheme
(S)-benzyl 2-((S)-2-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido)-4-methylpentanamido)-3-phenylpropanoate
868540-15-2

(S)-benzyl 2-((S)-2-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido)-4-methylpentanamido)-3-phenylpropanoate

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloromethane / 1 h / 20 °C
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
3: 5 mol% Pd/C; hydrogen / methanol / 0.5 h
View Scheme
C2HF3O2*C32H39N3O4
875309-83-4

C2HF3O2*C32H39N3O4

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
2: 5 mol% Pd/C; hydrogen / methanol / 0.5 h
View Scheme
Leu-Phe-OMe trifluoroacetate

Leu-Phe-OMe trifluoroacetate

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
2: dichloromethane / 3 h / 0 - 20 °C
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
4: lithium hydroxide monohydrate / methanol / 3 h / 0 - 20 °C
View Scheme
C2HF3O2*C26H35N3O4
868539-99-5

C2HF3O2*C26H35N3O4

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
2: lithium hydroxide monohydrate / methanol / 3 h / 0 - 20 °C
View Scheme
N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: thionyl chloride / 2 h / 0 - 20 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
3: dichloromethane / 3 h / 0 - 20 °C
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
5: dichloromethane / 3 h / 0 - 20 °C
6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
7: lithium hydroxide monohydrate / methanol / 3 h / 0 - 20 °C
View Scheme
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C9H17NO2*C4HF7O2

C9H17NO2*C4HF7O2

carfilzomib

carfilzomib

Conditions
ConditionsYield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine In N,N-dimethyl-formamide at -5℃; for 1.5h;88%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C9H17NO2*C2HF3O2

C9H17NO2*C2HF3O2

(S)-4-methyl-N-((S)-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxohexan-2-yl) amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenyl butanamido)pentanamide

(S)-4-methyl-N-((S)-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxohexan-2-yl) amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenyl butanamido)pentanamide

Conditions
ConditionsYield
Stage #1: (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid With benzotriazol-1-ol In dichloromethane for 0.333333h;
Stage #2: C9H17NO2*C2HF3O2 With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12.5h; Cooling;
87%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C9H17NO2*C3HF5O2

C9H17NO2*C3HF5O2

carfilzomib

carfilzomib

Conditions
ConditionsYield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine In N,N-dimethyl-formamide at -5℃; for 1.5h; Temperature; Reagent/catalyst;86%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

(2R,4S)-4-((tert-butoxycarbonyl)amino)-2-hydroxy-2,6-dimethyl-3-oxoheptyl 3-(prop-2-yn-1-yloxy)propane-1-sulfonate

(2R,4S)-4-((tert-butoxycarbonyl)amino)-2-hydroxy-2,6-dimethyl-3-oxoheptyl 3-(prop-2-yn-1-yloxy)propane-1-sulfonate

(4S,7S,10S,13S,15R)-10-benzyl-15-hydroxy-7,13-diisobutyl-15-methyl-1-morpholino-2,5,8,11,14-pentaoxo-4-phenethyl-3,6,9,12-tetraazahexadecan-16-yl 3-(prop-2-yn-1-ylcarbamoyl)benzenesulfonate
1541172-80-8

(4S,7S,10S,13S,15R)-10-benzyl-15-hydroxy-7,13-diisobutyl-15-methyl-1-morpholino-2,5,8,11,14-pentaoxo-4-phenethyl-3,6,9,12-tetraazahexadecan-16-yl 3-(prop-2-yn-1-ylcarbamoyl)benzenesulfonate

Conditions
ConditionsYield
Stage #1: (2R,4S)-4-((tert-butoxycarbonyl)amino)-2-hydroxy-2,6-dimethyl-3-oxoheptyl 3-(prop-2-yn-1-yloxy)propane-1-sulfonate With hydrogenchloride In 1,4-dioxane at 20℃; for 1h;
Stage #2: (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.5h;
80%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

(S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate
1148157-29-2

(S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate

(S)-4-methyl-N-((S)-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenyl butanamido)pentanamide

(S)-4-methyl-N-((S)-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenyl butanamido)pentanamide

Conditions
ConditionsYield
Stage #1: (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid With benzotriazol-1-ol In dichloromethane for 0.333333h;
Stage #2: (S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12.5h; Cooling;
80%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C13H17NO2*C2HF3O2

C13H17NO2*C2HF3O2

(S)-4-methyl-N-((S)-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-4-phenylbutan-2 -yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

(S)-4-methyl-N-((S)-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-4-phenylbutan-2 -yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

Conditions
ConditionsYield
Stage #1: (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid With benzotriazol-1-ol In dichloromethane for 0.333333h;
Stage #2: C13H17NO2*C2HF3O2 With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12.5h; Cooling;
76%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C7H13NO2*C2HF3O2

C7H13NO2*C2HF3O2

(S)-4-methyl-N-((S)-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxobutan-2-yl) amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenyl butanamido)pentanamide

(S)-4-methyl-N-((S)-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxobutan-2-yl) amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenyl butanamido)pentanamide

Conditions
ConditionsYield
Stage #1: (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid With benzotriazol-1-ol In dichloromethane for 0.333333h;
Stage #2: C7H13NO2*C2HF3O2 With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12.5h; Cooling;
73%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C16H21NO5S*ClH

C16H21NO5S*ClH

trifluoroacetic acid
76-05-1

trifluoroacetic acid

C47H61N5O10S*C2HF3O2

C47H61N5O10S*C2HF3O2

Conditions
ConditionsYield
Stage #1: (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; for 0.333333h;
Stage #2: C16H21NO5S*ClH In dichloromethane at 0℃; for 0.166667h;
Stage #3: trifluoroacetic acid With N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃;
60%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C12H19NO3S*ClH

C12H19NO3S*ClH

trifluoroacetic acid
76-05-1

trifluoroacetic acid

C43H59N5O8S*C2HF3O2

C43H59N5O8S*C2HF3O2

Conditions
ConditionsYield
Stage #1: (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; for 0.333333h;
Stage #2: C12H19NO3S*ClH In dichloromethane at 0℃; for 0.166667h;
Stage #3: trifluoroacetic acid With N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃;
53%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C2HF3O2*C10H19NO3

C2HF3O2*C10H19NO3

(S)-N-((S)-1-((S)-1-((S)-2-(methoxymethyl)oxiran-2-yl)-4-methyl-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

(S)-N-((S)-1-((S)-1-((S)-2-(methoxymethyl)oxiran-2-yl)-4-methyl-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

Conditions
ConditionsYield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;48%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

L-Leu-[CH2SO2]-DFHMC . HC1

L-Leu-[CH2SO2]-DFHMC . HC1

MorphAc-hPhe-Leu-Phe-W-[CH2SO2]-DFHMC . TFA

MorphAc-hPhe-Leu-Phe-W-[CH2SO2]-DFHMC . TFA

Conditions
ConditionsYield
Stage #1: (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; for 0.333333h;
Stage #2: L-Leu-[CH2SO2]-DFHMC . HC1 In dichloromethane at 0℃; for 0.166667h;
Stage #3: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;
47.3%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

L-Leu-[CH2SO2]-DFHMC . HC1

L-Leu-[CH2SO2]-DFHMC . HC1

trifluoroacetic acid
76-05-1

trifluoroacetic acid

C47H59F2N5O10S*C2HF3O2

C47H59F2N5O10S*C2HF3O2

Conditions
ConditionsYield
Stage #1: (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; for 0.333333h;
Stage #2: L-Leu-[CH2SO2]-DFHMC . HC1 In dichloromethane at 0℃; for 0.166667h;
Stage #3: trifluoroacetic acid With N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃;
47%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C25H35NO3Si*C2HF3O2

C25H35NO3Si*C2HF3O2

(S)-N-((S)-1-((S)-1-((S)-2-((tert-butyldiphenylsilyloxy)methyl)oxiran-2-yl)-4-methyl-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

(S)-N-((S)-1-((S)-1-((S)-2-((tert-butyldiphenylsilyloxy)methyl)oxiran-2-yl)-4-methyl-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

Conditions
ConditionsYield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;45%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C12H14F5NO3S*ClH

C12H14F5NO3S*ClH

trifluoroacetic acid
76-05-1

trifluoroacetic acid

C43H54F5N5O8S*C2HF3O2

C43H54F5N5O8S*C2HF3O2

Conditions
ConditionsYield
Stage #1: (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; for 0.333333h;
Stage #2: C12H14F5NO3S*ClH In dichloromethane at 0℃; for 0.166667h;
Stage #3: trifluoroacetic acid With N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃;
36%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C16H20FNO5S*ClH

C16H20FNO5S*ClH

trifluoroacetic acid
76-05-1

trifluoroacetic acid

C47H60FN5O10S*C2HF3O2

C47H60FN5O10S*C2HF3O2

Conditions
ConditionsYield
Stage #1: (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; for 0.333333h;
Stage #2: C16H20FNO5S*ClH In dichloromethane at 0℃; for 0.166667h;
Stage #3: trifluoroacetic acid With N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃;
31%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C12H16F3NO3S*ClH

C12H16F3NO3S*ClH

trifluoroacetic acid
76-05-1

trifluoroacetic acid

C43H56F3N5O8S*C2HF3O2

C43H56F3N5O8S*C2HF3O2

Conditions
ConditionsYield
Stage #1: (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; for 0.333333h;
Stage #2: C12H16F3NO3S*ClH In dichloromethane at 0℃; for 0.166667h;
Stage #3: trifluoroacetic acid With N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃;
23%
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

(2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]pentan-1-one
247068-84-4

(2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]pentan-1-one

carfilzomib

carfilzomib

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 5℃;
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt

(x)C6H8O7*C40H57N5O7

(x)C6H8O7*C40H57N5O7

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 0 - 5 °C
2: tetrahydrofuran; acetonitrile / 2 h / 20 °C
View Scheme
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt

carfilzomib

carfilzomib

Conditions
ConditionsYield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 5℃; for 1.5h; Reagent/catalyst; Temperature; Solvent; stereoselective reaction;230 g
With 4-methyl-morpholine; benzotriazol-1-ol; HATU In N,N-dimethyl-formamide at 0 - 5℃; for 3h; Inert atmosphere;100.0 g
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 5℃; Inert atmosphere;0.08 g
Multi-step reaction with 2 steps
1.1: benzotriazol-1-ol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / -10 - -5 °C
1.2: 0.5 h / 25 - 30 °C
2.1: sodium hydrogencarbonate / dichloromethane; water / 0.17 h / 2 - 6 °C
View Scheme
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C9H17NO2*CH2O2

C9H17NO2*CH2O2

(x)C6H8O7*C40H57N5O7

(x)C6H8O7*C40H57N5O7

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 1 h / 0 °C
2: tetrahydrofuran; acetonitrile / 2 h / 20 °C
View Scheme
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
868540-16-3

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

C9H17NO2*CH2O2

C9H17NO2*CH2O2

carfilzomib

carfilzomib

Conditions
ConditionsYield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine at 0℃; for 1h;

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