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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality Estra-1,3,5(10)-triene-3,17-diol,7-[9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl]-,17-acetate,(7a,17b)-

Cas:875573-69-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 875573-69-6 with competitive price

Cas:875573-69-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pudo

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonyl]-estra-1,3,5(10)-triene-3,17-diol 17-acetate 875573-69-6

Cas:875573-69-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Fulvestrant intermediate N-3 CAS 875573-69-6

Cas:875573-69-6

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Estra-1,3,5(10)-triene-3,17-diol,7-[9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl]-,17-acetate,(7a,17b)- CAS:875573-69-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, product

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonyl]-estra-1,3,5(10)-triene-3,17-diol 17-acetate

Cas:875573-69-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Estra-1,3,5(10)-triene-3,17-diol,7-[9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl]-,17-acetate,(7a,17b)- Synonyms: (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonyl]-estra-1,3,5(10)-triene-3,17-diol 17-acetate;(7R,8R,9S,13S,14S,17

Fulvestrant intermediate-6 Manufactuered in China best quality

Cas:875573-69-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Fulvestrant Intermediates 875573-69-6

Cas:875573-69-6

Min.Order:50 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(7alpha,17beta)-7-[9-(4,4,5,5,5-pentafluoropentyl)thio]nonyl]estra-1,3,5(10)- triene-3-diol-17oxyethyl

Cas:875573-69-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonyl]-estra-1,3,5(10)-triene-3,17-diol 17-acetate

Cas:875573-69-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

high quality Estra-1,3,5(10)-triene-3,17-diol,7-[9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl]-,17-acetate,(7a,17b)-

Cas:875573-69-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonyl]estra-1,3,5(10)-Triene-3-Diol-17oxyethyl CAS No.:875573-69-6 Molecule Formula:C34H49F5O3S Molecule Weight:632.81 Purity: 99.0% Package: 25kg/drum Description:White pow

Kono Chem Co.,Ltd

Product Name: Estra-1,3,5(10)-triene-3,17-diol,7-[9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl]-,17-acetate,(7a,17b)- Synonyms: Estra-1,3,5(10)-triene-…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

(7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonyl]-estra-1,3,5(10)-triene-3,17-diol 17-acetateCAS NO.: 875573-69-6

Cas:875573-69-6

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Estra-1,3,5(10)-triene-3,17-diol,7-[9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl]-,17-acetate,(7a,17b)- Chemical Properties Boiling point 631.4±55.0 °C(Predicted) density 1.19 storage temp. Sealed in dry,Room Temperature pka 1

Estra-1,3,5(10)-triene-3,17-diol,7-[9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl]-,17-acetate,(7a,17b)-

Cas:875573-69-6

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

(7A,17B)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)Thio]Nonyl]-Estra-1,3,5(10)-Triene-3,17-Diol 17-Acetate

Cas:875573-69-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(+)-(7α)-[9-bromononyl]estra-1,3,5(10)-triene-3-ol-17β-yl acetate
875573-66-3

(+)-(7α)-[9-bromononyl]estra-1,3,5(10)-triene-3-ol-17β-yl acetate

C6H9F5N2S*ClH

C6H9F5N2S*ClH

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
Stage #1: (+)-(7α)-[9-bromononyl]estra-1,3,5(10)-triene-3-ol-17β-yl acetate; C6H9F5N2S*ClH With potassium hydroxide In N,N-dimethyl-formamide at 0 - 10℃; for 1.5h;
Stage #2: With acetic acid In ethyl acetate; N,N-dimethyl-formamide for 0.166667h;
85%
1-methanesulfonyloxy-4,4,5,5,5-pentafluoropentane
252947-01-6

1-methanesulfonyloxy-4,4,5,5,5-pentafluoropentane

C29H44O3S

C29H44O3S

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 48h; Inert atmosphere; Reflux;80%
(+)-(7α)-[9-bromononyl]estra-1,3,5(10)-triene-3-ol-17β-yl acetate
875573-66-3

(+)-(7α)-[9-bromononyl]estra-1,3,5(10)-triene-3-ol-17β-yl acetate

4,4,5,5,5-pentafluoro-1-pentanethiol
148757-88-4

4,4,5,5,5-pentafluoro-1-pentanethiol

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl acetamide; water at 20℃; for 0.6h; Product distribution / selectivity;
1-methanesulfonyloxy-4,4,5,5,5-pentafluoropentane
252947-01-6

1-methanesulfonyloxy-4,4,5,5,5-pentafluoropentane

BrH*C29H46N2O3S

BrH*C29H46N2O3S

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl acetamide; water at 20℃; for 1h; Product distribution / selectivity;
C29H44O3

C29H44O3

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C
2: 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Reflux
3: hydrazine hydrate / tetrahydrofuran / 4 h / 20 °C
4: potassium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux
View Scheme
C31H44O4

C31H44O4

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Reflux
2: hydrazine hydrate / tetrahydrofuran / 4 h / 20 °C
3: potassium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux
View Scheme
C33H48O5S

C33H48O5S

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrazine hydrate / tetrahydrofuran / 4 h / 20 °C
2: potassium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux
View Scheme
19-nortestosterone
434-22-0

19-nortestosterone

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / 1 h / Reflux
2.1: N-Bromosuccinimide / N,N-dimethyl-formamide; water / 1.25 h / 0 - 7 °C / Inert atmosphere
2.2: 2 h / 0 °C / Reflux; Inert atmosphere
3.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere
3.2: 0.5 h / -20 - 20 °C
4.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C
5.1: 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Reflux
6.1: hydrazine hydrate / tetrahydrofuran / 4 h / 20 °C
7.1: potassium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux
View Scheme
4,4,5,5,5-pentafluorpentan-1-ol
148043-73-6

4,4,5,5,5-pentafluorpentan-1-ol

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / acetonitrile / 4 h / 20 °C / Inert atmosphere
2: potassium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 2 h / 20 °C / Cooling with ice
2: ethanol / Reflux
3: sodium hydroxide / water; methanol / 24 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: thionyl chloride; triethylamine / dichloromethane / 2 h / 0 - 20 °C
2.1: isopropyl alcohol / 80 - 85 °C
3.1: potassium hydroxide / N,N-dimethyl-formamide / 1.5 h / 0 - 10 °C
3.2: 0.17 h
View Scheme
3,17β-diacetoxy-estra-3,5-diene
4999-76-2

3,17β-diacetoxy-estra-3,5-diene

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: N-Bromosuccinimide / N,N-dimethyl-formamide; water / 1.25 h / 0 - 7 °C / Inert atmosphere
1.2: 2 h / 0 °C / Reflux; Inert atmosphere
2.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere
2.2: 0.5 h / -20 - 20 °C
3.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C
4.1: 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Reflux
5.1: hydrazine hydrate / tetrahydrofuran / 4 h / 20 °C
6.1: potassium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux
View Scheme
6-dehydro-19-nortestosterone acetate
2590-41-2

6-dehydro-19-nortestosterone acetate

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere
1.2: 0.5 h / -20 - 20 °C
2.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C
3.1: 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Reflux
4.1: hydrazine hydrate / tetrahydrofuran / 4 h / 20 °C
5.1: potassium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux
View Scheme
(7α,17β)-7-[9-(methanesulfonyloxy)nonyl]estra-1,3,5(10)-triene-3,17-diol-17-acetate

(7α,17β)-7-[9-(methanesulfonyloxy)nonyl]estra-1,3,5(10)-triene-3,17-diol-17-acetate

S-(4,4,5,5,5-pentafluoropentyl)isothiourea methanesulfonate

S-(4,4,5,5,5-pentafluoropentyl)isothiourea methanesulfonate

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
With sodium hydroxide In methanol; water for 24h; Inert atmosphere; Reflux;
1-methanesulfonyloxy-4,4,5,5,5-pentafluoropentane
252947-01-6

1-methanesulfonyloxy-4,4,5,5,5-pentafluoropentane

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol / Reflux
2: sodium hydroxide / water; methanol / 24 h / Inert atmosphere; Reflux
View Scheme
1,1,1,2,2-pentafluoro-5-chloro-n-pentane

1,1,1,2,2-pentafluoro-5-chloro-n-pentane

17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: isopropyl alcohol / 80 - 85 °C
2.1: potassium hydroxide / N,N-dimethyl-formamide / 1.5 h / 0 - 10 °C
2.2: 0.17 h
View Scheme
17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

(+)-(7α)-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5(10)-triene-3,17β-diol
153004-31-0

(+)-(7α)-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5(10)-triene-3,17β-diol

Conditions
ConditionsYield
Stage #1: 17-O-acetyl-S-deoxo-fulvestrant With potassium hydroxide In methanol at 40℃; for 2h;
Stage #2: With acetic acid In methanol; ethyl acetate for 0.166667h;
78.2%
With methanol; potassium hydroxide at 20℃; for 1 - 4h; Product distribution / selectivity;
17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

ICI 182,780-17β-acetate
261506-24-5

ICI 182,780-17β-acetate

Conditions
ConditionsYield
With sodium periodate In tetrahydrofuran; methanol; water at 5 - 20℃;
17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

(7R,8R,9S,13S,14S,17S)-13-methyl-7-(9 - ( (4 , 4 , 5, 5 , 5-pentafluoropentyl)thio)nonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta-[a]phenanthren-17-yl acetate

(7R,8R,9S,13S,14S,17S)-13-methyl-7-(9 - ( (4 , 4 , 5, 5 , 5-pentafluoropentyl)thio)nonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta-[a]phenanthren-17-yl acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / dichloromethane / -10 °C
2: potassium acetate; tricyclohexylphosphine; palladium diacetate / acetonitrile / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: pyridine / dichloromethane-d2 / -10 °C
2: palladium diacetate; tricyclohexylphosphine / acetonitrile / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: pyridine / dichloromethane
2: palladium diacetate; tricyclohexylphosphine / acetonitrile / 80 °C
View Scheme
17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

(7R,8R,9S,13S,14S,17S)-13-methyl-7-(9 - ( (4 , 4 , 5, 5 , 5-pentafluoropentyl)thio)nonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta-[a]phenanthren-17-ol

(7R,8R,9S,13S,14S,17S)-13-methyl-7-(9 - ( (4 , 4 , 5, 5 , 5-pentafluoropentyl)thio)nonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta-[a]phenanthren-17-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine / dichloromethane / -10 °C
2: potassium acetate; tricyclohexylphosphine; palladium diacetate / acetonitrile / 80 °C / Inert atmosphere
3: potassium hydroxide / methanol; tetrahydrofuran / 4 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: pyridine / dichloromethane-d2 / -10 °C
2: palladium diacetate; tricyclohexylphosphine / acetonitrile / 80 °C
3: potassium hydroxide; methanol / tetrahydrofuran / 4 h / 0 - 20 °C
View Scheme
17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

C38H58BF5O4S

C38H58BF5O4S

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine / dichloromethane / -10 °C
2: potassium acetate; tricyclohexylphosphine; palladium diacetate / acetonitrile / 80 °C / Inert atmosphere
3: potassium hydroxide / methanol; tetrahydrofuran / 4 h / 0 - 20 °C
4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
View Scheme
17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

(7R,8R,9S,13S,14S,17S)-13-methyl-7-(9 - ( (4 , 4 , 5, 5 , 5-pentafluoropentyl)thio)nonyl)-3-(((trifluoromethyl)sulfonyl)oxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]-phenanthren-17-yl acetate

(7R,8R,9S,13S,14S,17S)-13-methyl-7-(9 - ( (4 , 4 , 5, 5 , 5-pentafluoropentyl)thio)nonyl)-3-(((trifluoromethyl)sulfonyl)oxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]-phenanthren-17-yl acetate

Conditions
ConditionsYield
With pyridine In dichloromethane at -10℃;0.7 g
With pyridine In dichloromethane-d2 at -10℃;
With pyridine In dichloromethane
17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)boronic acid

((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)boronic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine / dichloromethane-d2 / -10 °C
2: palladium diacetate; tricyclohexylphosphine / acetonitrile / 80 °C
3: potassium hydroxide; methanol / tetrahydrofuran / 4 h / 0 - 20 °C
4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
View Scheme
Multi-step reaction with 4 steps
1: pyridine / dichloromethane
2: palladium diacetate; tricyclohexylphosphine / acetonitrile / 80 °C
3: methanol; potassium hydroxide / tetrahydrofuran
4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
View Scheme
17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)boronic acid

((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)boronic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine / dichloromethane
2: palladium diacetate; tricyclohexylphosphine / acetonitrile / 80 °C
3: methanol; potassium hydroxide / tetrahydrofuran
View Scheme
17-O-acetyl-S-deoxo-fulvestrant
875573-69-6

17-O-acetyl-S-deoxo-fulvestrant

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
With sodium periodate In methanol; water at 20℃; for 24h; Cooling with ice;

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