As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:91374-20-8
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquirySpecifications CAS No.: 91374-20-8 Other Names: Ropinirole MF: C16H24N2O EINECS No.: / Place of Origin: Shaanxi, China (Mainland), S
Cas:91374-20-8
Min.Order:1 Gram
FOB Price: $40.0
Type:Other
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Light yellow crystalline powder Storage:Store at RT. Pack
Cas:91374-20-8
Min.Order:10 Gram
FOB Price: $15.0 / 20.0
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:91374-20-8
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Cas:91374-20-8
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:91374-20-8
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:91374-20-8
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:91374-20-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:91374-20-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryName: Ropinirol hydrochloride Synonyms: ROPINIROLE HCL CAS:91374-20-8 MF: C16H25ClN2O Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application: APIs Transportation:By sea or by air Port:
1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
Cas:91374-20-8
Min.Order:0 Metric Ton
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Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:91374-20-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:91374-20-8
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:91374-20-8
Min.Order:1 Kilogram
FOB Price: $82.0 / 86.0
Type:Trading Company
inquiryRopinirole hydrochloride CAS:91374-20-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic
Cas:91374-20-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:91374-20-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried
Cas:91374-20-8
Min.Order:1 Kilogram
FOB Price: $20.0 / 30.0
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:91374-20-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:91374-20-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:91374-20-8
Min.Order:100 Milligram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:91374-20-8
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:91374-20-8
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:91374-20-8
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality Appearance:Off-White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:antiparkinsonian;non-ergoline D2, D3, and D4 dopamine
Cas:91374-20-8
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryRopinirole hydrochloride Basic information Product Name: Ropinirole hydrochloride Synonyms: 1,3-dihydro-4-(2-(dipropylamino)ethyl)-2h-indol-2-onemonohydrochloride;1,3-dihydro-4-(2-(dipropylamino)ethyl)-2h-indol-2-onmonohydrochloride;4-(2-(dipropy
Cas:91374-20-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct name: Ropinirole Hydrochloride CAS No.:91374-20-8 Molecule Formula:C16H25ClN2O Molecule Weight:296.83 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING I
Cas:91374-20-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. DMF is available. Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and
Cas:91374-20-8
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:91374-20-8
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
Stage #1: propionic acid With sodium tetrahydroborate In toluene at 0 - 5℃; Stage #2: N-Despropylropinirole With sodium tetrahydroborate In toluene at 25 - 80℃; for 3h; Stage #3: With hydrogenchloride In water; isopropyl alcohol | 98% |
<2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride
ropinirole hydrochloride
Conditions | Yield |
---|---|
Stage #1: <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride With hydrogen; palladium 10% on activated carbon In water at 30 - 35℃; under 2942.29 Torr; for 8h; Stage #2: With sodium hydroxide In water pH=10 - 11; Stage #3: With hydrogenchloride In ethanol at 0 - 20℃; for 0.5 - 0.666667h; pH=2.0 - 3.0; | 87.2% |
Stage #1: <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride With hydrogen; palladium 10% on activated carbon In ethanol at 35 - 45℃; under 2206.72 - 4413.43 Torr; for 25h; Stage #2: With hydrogenchloride In ethanol at 15 - 25℃; for 0.5 - 0.666667h; pH=1.5 - 2.5; | 66.8% |
With hydrogen; palladium 10% on activated carbon In methanol | |
Stage #1: <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride With hydrogen; 5% Pd(II)/C(eggshell) In methanol at 25 - 35℃; under 2059.6 - 3236.52 Torr; Sealed tube; Stage #2: With hydrogenchloride In isopropyl alcohol; toluene at 0 - 35℃; |
di-n-propylamine
2-(2-oxo-2,3-dihydro-1H-indol-4-yl)ethyl-4-methylbenzene-1-sulfonate
ropinirole hydrochloride
Conditions | Yield |
---|---|
In water at 80℃; for 5h; | 87% |
With hydrogenchloride In water Large scale; | 85% |
Ropinirole
ropinirole hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane; water | 78% |
With hydrogenchloride In water | |
With hydrogenchloride In isopropyl alcohol; toluene at 15 - 20℃; for 1h; Purification / work up; |
di-n-propylamine
ropinirole hydrochloride
Conditions | Yield |
---|---|
Stage #1: methyl 2-(2-((tert-butoxycarbonyl)amino)-6-(2-oxoethyl)phenyl)acetate; di-n-propylamine With acetic acid In dichloromethane for 0.166667h; Stage #2: With sodium cyanoborohydride In dichloromethane for 2h; Stage #3: With hydrogenchloride In dichloromethane; water for 16h; | 73% |
di-n-propylamine
4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one
A
ropinirole hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water Large scale; | A 57% B 38% |
di-n-propylamine
4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one
ropinirole hydrochloride
Conditions | Yield |
---|---|
Stage #1: di-n-propylamine; 4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one In water; acetonitrile at 65 - 70℃; for 1.25h; Stage #2: With hydrogenchloride In water pH=2; | 50% |
ropinirole hydrochloride
Conditions | Yield |
---|---|
Stage #1: N-[(phenylacetyl)oxy]-2-{2-[2-(dipropylamino)ethyl]phenyl}acetamide hydrochloride With iron(III) chloride In dichloromethane for 2h; Heating / reflux; Stage #2: With ammonia In methanol; dichloromethane; water Stage #3: With hydrogenchloride In water; isopropyl alcohol Product distribution / selectivity; | 41.7% |
2-{2-[2-(dipropylamino)ethyl]phenyl}-N-hydroxyacetamide
ropinirole hydrochloride
Conditions | Yield |
---|---|
Stage #1: 2-{2-[2-(dipropylamino)ethyl]phenyl}-N-hydroxyacetamide With acetyl chloride In dichloromethane at 20℃; for 0.5h; Stage #2: With iron(III) chloride In dichloromethane at 50℃; for 2h; Heating / reflux; Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages; | 41.1% |
Stage #1: 2-{2-[2-(dipropylamino)ethyl]phenyl}-N-hydroxyacetamide With benzoyl chloride In dichloromethane at 20℃; for 0.5h; Stage #2: With iron(III) chloride In dichloromethane for 2h; Heating / reflux; Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages; | 25.3% |
propionaldehyde
ropinirole hydrochloride
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In methanol at 20℃; under 3677.86 Torr; for 24h; | 41% |
ropinirole hydrochloride
Conditions | Yield |
---|---|
palladium In ethanol; acetonitrile |
di-n-propylamine
4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-indolin-2-one
ropinirole hydrochloride
Conditions | Yield |
---|---|
Stage #1: di-n-propylamine; 4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-indolin-2-one In water; toluene Inert atmosphere; Reflux; Stage #2: With sodium tetrahydroborate In water; acetonitrile Stage #3: With hydrogenchloride In dichloromethane; water; acetonitrile at 5℃; for 1h; |
N-[2-(2-methyl-3-nitrophenyl)ethyl]-N-propylpropan-1-amine hydrochloride
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ethanol; sodium / tetrahydrofuran / 15 - 30 °C / Inert atmosphere 1.2: 25 - 30 °C 2.1: sodium hydroxide; water / toluene; methanol / 0 - 5 °C / pH 12 2.2: 15 °C 2.3: 25 - 70 °C / pH < 2 / Activated charcoal 3.1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 25 - 35 °C / 2059.6 - 3236.52 Torr / Sealed tube 3.2: 0 - 35 °C View Scheme |
4-[2-(benzoyloxy)ethyl]-3-chloro-1,3-dihydro-2H-indolin-2-one
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: palladium on activated charcoal; hydrazine hydrate 2: sodium hydroxide; water / Large scale 3: pyridine / Large scale 4: hydrogenchloride / water / Large scale View Scheme | |
Multi-step reaction with 4 steps 1: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux 2: sodium hydroxide; water / methanol / 4 h / Reflux 3: dichloromethane; pyridine / 3 h / 5 - 10 °C 4: water / 5 h / 80 °C View Scheme |
di-n-propylamine
A
ropinirole hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water |
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: bromine / water / Irradiation 2: water; methanol / Acidic conditions; Large scale 3: iron(III) chloride / Acidic conditions; Large scale 4: palladium on activated charcoal; sodium hypophosphite monohydrate / water; ethyl acetate / Large scale 5: hydrogenchloride / water / Large scale View Scheme |
1-Bromoisochromane
A
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: water; methanol / Acidic conditions; Large scale 2: iron(III) chloride / Acidic conditions; Large scale 3: palladium on activated charcoal; sodium hypophosphite monohydrate / water; ethyl acetate / Large scale 4: hydrogenchloride / water / Large scale View Scheme |
di-n-propylamine
A
ropinirole hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water |
A
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: iron(III) chloride / Acidic conditions; Large scale 2: palladium on activated charcoal; sodium hypophosphite monohydrate / water; ethyl acetate / Large scale 3: hydrogenchloride / water / Large scale View Scheme |
4-(2-benzoyloxyethyl)-1,3-dihydro-2H-indolin-2-one
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide; water / Large scale 2: pyridine / Large scale 3: hydrogenchloride / water / Large scale View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide; water / methanol / 4 h / Reflux 2: dichloromethane; pyridine / 3 h / 5 - 10 °C 3: water / 5 h / 80 °C View Scheme |
4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-indolin-2-one
A
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: palladium on activated charcoal; sodium hypophosphite monohydrate / water; ethyl acetate / Large scale 2: hydrogenchloride / water / Large scale View Scheme |
benzoic acid (2-(2-nitroethenyl))phenethyl ester
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: iron(III) chloride; acetyl chloride / water; dichloromethane / 3 h / 5 °C / Cooling with ice 2: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux 3: sodium hydroxide; water / methanol / 4 h / Reflux 4: dichloromethane; pyridine / 3 h / 5 - 10 °C 5: water / 5 h / 80 °C View Scheme |
2-phenylethanol
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: hydrogenchloride / water / 20 h / 36 °C 2.1: zinc(II) chloride / dichloromethane / Reflux 2.2: 1.5 h / Reflux 3.1: dimethyl sulfoxide; sodium hydrogencarbonate / 3 h / 110 °C 4.1: ammonium acetate / 10 h / Reflux 5.1: iron(III) chloride; acetyl chloride / water; dichloromethane / 3 h / 5 °C / Cooling with ice 6.1: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux 7.1: sodium hydroxide; water / methanol / 4 h / Reflux 8.1: dichloromethane; pyridine / 3 h / 5 - 10 °C 9.1: water / 5 h / 80 °C View Scheme |
isochromane
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: zinc(II) chloride / dichloromethane / Reflux 1.2: 1.5 h / Reflux 2.1: dimethyl sulfoxide; sodium hydrogencarbonate / 3 h / 110 °C 3.1: ammonium acetate / 10 h / Reflux 4.1: iron(III) chloride; acetyl chloride / water; dichloromethane / 3 h / 5 °C / Cooling with ice 5.1: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux 6.1: sodium hydroxide; water / methanol / 4 h / Reflux 7.1: dichloromethane; pyridine / 3 h / 5 - 10 °C 8.1: water / 5 h / 80 °C View Scheme |
2-[2-(chloromethyl)phenyl]ethylbenzoate
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: dimethyl sulfoxide; sodium hydrogencarbonate / 3 h / 110 °C 2: ammonium acetate / 10 h / Reflux 3: iron(III) chloride; acetyl chloride / water; dichloromethane / 3 h / 5 °C / Cooling with ice 4: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux 5: sodium hydroxide; water / methanol / 4 h / Reflux 6: dichloromethane; pyridine / 3 h / 5 - 10 °C 7: water / 5 h / 80 °C View Scheme |
benzoic acid (2-formyl)phenethyl ester
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: ammonium acetate / 10 h / Reflux 2: iron(III) chloride; acetyl chloride / water; dichloromethane / 3 h / 5 °C / Cooling with ice 3: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux 4: sodium hydroxide; water / methanol / 4 h / Reflux 5: dichloromethane; pyridine / 3 h / 5 - 10 °C 6: water / 5 h / 80 °C View Scheme |
2-(1H-indol-4-yl)acetic acid
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 2: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C 3: 0.01 h / -40 - 80 °C 4: palladium on activated charcoal; hydrogen / 2 h / 20 °C 5: pyridine / 2 h / 20 °C 6: sodium iodide / 4 h / 100 °C 7: hydrogenchloride / 1,4-dioxane; water View Scheme |
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C 2: 0.01 h / -40 - 80 °C 3: palladium on activated charcoal; hydrogen / 2 h / 20 °C 4: pyridine / 2 h / 20 °C 5: sodium iodide / 4 h / 100 °C 6: hydrogenchloride / 1,4-dioxane; water View Scheme |
ropinirole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 0.01 h / -40 - 80 °C 2: palladium on activated charcoal; hydrogen / 2 h / 20 °C 3: pyridine / 2 h / 20 °C 4: sodium iodide / 4 h / 100 °C 5: hydrogenchloride / 1,4-dioxane; water View Scheme |
ropinirole hydrochloride
Ropinirole
Conditions | Yield |
---|---|
With sodium hydroxide In water at 20℃; for 0.25h; | 94% |
With sodium hydroxide In water for 0.25h; | 86% |
With ammonia; water at 22 - 25℃; for 0.5h; Purification / work up; |
Conditions | Yield |
---|---|
Stage #1: formaldehyd; ropinirole hydrochloride With N-ethyl-N,N-diisopropylamine In methanol; water at 60℃; for 18h; Stage #2: With sulfuric acid In methanol; water Reagent/catalyst; Temperature; Solvent; | 71% |
formaldehyd
ropinirole hydrochloride
Conditions | Yield |
---|---|
Stage #1: formaldehyd; ropinirole hydrochloride With triethylamine In methanol; water at 60℃; for 18h; Stage #2: With hydrogenchloride In methanol; water Reagent/catalyst; Temperature; Solvent; | 69% |
ropinirole hydrochloride
2-bromoethyl chloroformate
ropinirole-N-bromoethylcarboxylate
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane at 20℃; | 22.01% |
With triethylamine |
Conditions | Yield |
---|---|
With borate buffer at 100℃; for 0.5h; pH=8.5; |
ropinirole hydrochloride
A
4-(2-dipropylaminoethyl)-1-hydroxy-1,3-dihydroindol-2-one
B
4-(2-dipropylaminoethyl)-1H-indol-2,3-dione
C
2-nitro-6-<2-(di-n-propylamino)ethyl>phenylacetic acid
Conditions | Yield |
---|---|
With dihydrogen peroxide In dihydrogen peroxide at 80℃; for 5h; |
ropinirole hydrochloride
4-(2-((3-aminopropyl)(propyl)amino)ethyl)indolin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium hydroxide / water / 0.25 h / 20 °C 2.1: carbonochloridic acid 1-chloro-ethyl ester; sodium hydrogencarbonate / 17 h / 85 °C 2.2: 18 h / Reflux 3.1: sodium hydroxide / water / 0.08 h 4.1: potassium carbonate / acetonitrile / 19 h / Reflux 5.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium hydroxide / water / 0.25 h / 20 °C 2.1: carbonochloridic acid 1-chloro-ethyl ester; sodium hydrogencarbonate / 17 h / 85 °C 2.2: 18 h / Reflux 3.1: sodium hydroxide / water / 0.08 h 4.1: potassium carbonate / acetonitrile / 19 h / Reflux 5.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: sodium hydroxide / water / 0.25 h 2: sodium hydrogencarbonate / 17 h / 85 °C 3: sodium hydroxide / water / 1.5 h / 20 °C 4: potassium carbonate / acetonitrile / 19 h / Reflux 5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: sodium hydroxide / water / 0.25 h 2: sodium hydrogencarbonate / 17 h / 85 °C 3: sodium hydroxide / water / 1.5 h / 20 °C 4: potassium carbonate / acetonitrile / 19 h / Reflux 5: potassium carbonate / methanol; 1,4-dioxane / 1 h / 20 °C View Scheme |
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