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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ropinirole hydrochloride Manufacturer/High quality/Best price/In stock

Cas:91374-20-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

Specifications CAS No.: 91374-20-8 Other Names: Ropinirole MF: C16H24N2O EINECS No.: / Place of Origin: Shaanxi, China (Mainland), S

Contact Supplier Leave Messages Ropinirole Hydrochloride//CAS No.:91374-20-8

Cas:91374-20-8

Min.Order:1 Gram

FOB Price: $40.0

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Light yellow crystalline powder Storage:Store at RT. Pack

Manufacturer supply Ropinirole hydrochloride CAS 91374-20-8 with high purity

Cas:91374-20-8

Min.Order:10 Gram

FOB Price: $15.0 / 20.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ropinirole Hydrochloride

Cas:91374-20-8

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Ropinirole Hydrochloride

Cas:91374-20-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ropinirole hydrochloride

Cas:91374-20-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Ropinirole hydrochloride

Cas:91374-20-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 91374-20-8 with competitive price

Cas:91374-20-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Ropinirole hydrochloride/ LIDE PHARMA- Factory supply / Best price

Cas:91374-20-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name: Ropinirol hydrochloride Synonyms: ROPINIROLE HCL CAS:91374-20-8 MF: C16H25ClN2O Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application: APIs Transportation:By sea or by air Port:

Ropinirol hydrochloride

Cas:91374-20-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

Ropinirole hydrochloride

Cas:91374-20-8

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2H-Indol-2-one,4-[2-(dipropylamino)ethyl]-1,3-dihydro-, hydrochloride (1:1) 91374-20-8

Cas:91374-20-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Antiparkinsonian drugs Ropinirole hydrochloride CAS:91374-20-8

Cas:91374-20-8

Min.Order:1 Kilogram

FOB Price: $82.0 / 86.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Ropinirole hydrochloride CAS:91374-20-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

Ropinirole hydrochloride CAS:91374-20-8

Cas:91374-20-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ropinirole hydrochloride

Cas:91374-20-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

High Quality Ropinirole Hydrochloride CAS 91374-20-8

Cas:91374-20-8

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2H-Indol-2-one,4-[2-(dipropylamino)ethyl]-1,3-dihydro-, hydrochloride (1:1)

Cas:91374-20-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Ropinirole hydrochloride

Cas:91374-20-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Ropinirole hydrochloride 91374-20-8

Cas:91374-20-8

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-(2-Dipropylaminoethyl)-1,3-dihydroindol-2-one hydrochloride

Cas:91374-20-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Ropinirole Hydrochloride CAS 91374-20-8 with Fast Shipment

Cas:91374-20-8

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ropinirole

Cas:91374-20-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Ropinirole Hydrochloride

Cas:91374-20-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality Appearance:Off-White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:antiparkinsonian;non-ergoline D2, D3, and D4 dopamine

Ropinirole hydrochloride-

Cas:91374-20-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Ropinirole hydrochloride Basic information Product Name: Ropinirole hydrochloride Synonyms: 1,3-dihydro-4-(2-(dipropylamino)ethyl)-2h-indol-2-onemonohydrochloride;1,3-dihydro-4-(2-(dipropylamino)ethyl)-2h-indol-2-onmonohydrochloride;4-(2-(dipropy

TIANFU-CHEM Ropinirole hydrochloride

Cas:91374-20-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Ropinirole Hydrochloride CAS No.:91374-20-8 Molecule Formula:C16H25ClN2O Molecule Weight:296.83 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING I

High Quality Ropinirole Hydrochloride in stock

Cas:91374-20-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

1. DMF is available. Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and

Ropinirole hydrochloride

Cas:91374-20-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Ropinirole hydrochloride

Cas:91374-20-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

propionic acid
802294-64-0

propionic acid

N-Despropylropinirole

N-Despropylropinirole

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Stage #1: propionic acid With sodium tetrahydroborate In toluene at 0 - 5℃;
Stage #2: N-Despropylropinirole With sodium tetrahydroborate In toluene at 25 - 80℃; for 3h;
Stage #3: With hydrogenchloride In water; isopropyl alcohol
98%
<2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride
91374-25-3

<2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Stage #1: <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride With hydrogen; palladium 10% on activated carbon In water at 30 - 35℃; under 2942.29 Torr; for 8h;
Stage #2: With sodium hydroxide In water pH=10 - 11;
Stage #3: With hydrogenchloride In ethanol at 0 - 20℃; for 0.5 - 0.666667h; pH=2.0 - 3.0;
87.2%
Stage #1: <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride With hydrogen; palladium 10% on activated carbon In ethanol at 35 - 45℃; under 2206.72 - 4413.43 Torr; for 25h;
Stage #2: With hydrogenchloride In ethanol at 15 - 25℃; for 0.5 - 0.666667h; pH=1.5 - 2.5;
66.8%
With hydrogen; palladium 10% on activated carbon In methanol
Stage #1: <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride With hydrogen; 5% Pd(II)/C(eggshell) In methanol at 25 - 35℃; under 2059.6 - 3236.52 Torr; Sealed tube;
Stage #2: With hydrogenchloride In isopropyl alcohol; toluene at 0 - 35℃;
di-n-propylamine
142-84-7

di-n-propylamine

2-(2-oxo-2,3-dihydro-1H-indol-4-yl)ethyl-4-methylbenzene-1-sulfonate
139122-20-6

2-(2-oxo-2,3-dihydro-1H-indol-4-yl)ethyl-4-methylbenzene-1-sulfonate

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
In water at 80℃; for 5h;87%
With hydrogenchloride In water Large scale;85%
Ropinirole
91374-21-9

Ropinirole

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; water78%
With hydrogenchloride In water
With hydrogenchloride In isopropyl alcohol; toluene at 15 - 20℃; for 1h; Purification / work up;
methyl 2-(2-((tert-butoxycarbonyl)amino)-6-(2-oxoethyl)phenyl)acetate

methyl 2-(2-((tert-butoxycarbonyl)amino)-6-(2-oxoethyl)phenyl)acetate

di-n-propylamine
142-84-7

di-n-propylamine

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Stage #1: methyl 2-(2-((tert-butoxycarbonyl)amino)-6-(2-oxoethyl)phenyl)acetate; di-n-propylamine With acetic acid In dichloromethane for 0.166667h;
Stage #2: With sodium cyanoborohydride In dichloromethane for 2h;
Stage #3: With hydrogenchloride In dichloromethane; water for 16h;
73%
di-n-propylamine
142-84-7

di-n-propylamine

4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one
120427-96-5

4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one

A

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

B

4-ethylenyl-1,3-dihydro-2H-indol-2-one

4-ethylenyl-1,3-dihydro-2H-indol-2-one

Conditions
ConditionsYield
With hydrogenchloride In water Large scale;A 57%
B 38%
di-n-propylamine
142-84-7

di-n-propylamine

4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one
120427-96-5

4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Stage #1: di-n-propylamine; 4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one In water; acetonitrile at 65 - 70℃; for 1.25h;
Stage #2: With hydrogenchloride In water pH=2;
50%
N-[(phenylacetyl)oxy]-2-{2-[2-(dipropylamino)ethyl]phenyl}acetamide hydrochloride

N-[(phenylacetyl)oxy]-2-{2-[2-(dipropylamino)ethyl]phenyl}acetamide hydrochloride

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Stage #1: N-[(phenylacetyl)oxy]-2-{2-[2-(dipropylamino)ethyl]phenyl}acetamide hydrochloride With iron(III) chloride In dichloromethane for 2h; Heating / reflux;
Stage #2: With ammonia In methanol; dichloromethane; water
Stage #3: With hydrogenchloride In water; isopropyl alcohol Product distribution / selectivity;
41.7%
2-{2-[2-(dipropylamino)ethyl]phenyl}-N-hydroxyacetamide
863436-07-1

2-{2-[2-(dipropylamino)ethyl]phenyl}-N-hydroxyacetamide

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Stage #1: 2-{2-[2-(dipropylamino)ethyl]phenyl}-N-hydroxyacetamide With acetyl chloride In dichloromethane at 20℃; for 0.5h;
Stage #2: With iron(III) chloride In dichloromethane at 50℃; for 2h; Heating / reflux;
Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages;
41.1%
Stage #1: 2-{2-[2-(dipropylamino)ethyl]phenyl}-N-hydroxyacetamide With benzoyl chloride In dichloromethane at 20℃; for 0.5h;
Stage #2: With iron(III) chloride In dichloromethane for 2h; Heating / reflux;
Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages;
25.3%
4-(2'-aminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride

4-(2'-aminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride

propionaldehyde
123-38-6

propionaldehyde

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In methanol at 20℃; under 3677.86 Torr; for 24h;41%
2-nitro-6(2-di-n-propylaminoethyl)-phenyl acetic acid hydrochloride

2-nitro-6(2-di-n-propylaminoethyl)-phenyl acetic acid hydrochloride

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
palladium In ethanol; acetonitrile
di-n-propylamine
142-84-7

di-n-propylamine

4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-indolin-2-one
120427-95-4

4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-indolin-2-one

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Stage #1: di-n-propylamine; 4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-indolin-2-one In water; toluene Inert atmosphere; Reflux;
Stage #2: With sodium tetrahydroborate In water; acetonitrile
Stage #3: With hydrogenchloride In dichloromethane; water; acetonitrile at 5℃; for 1h;
N-[2-(2-methyl-3-nitrophenyl)ethyl]-N-propylpropan-1-amine hydrochloride
920986-68-1

N-[2-(2-methyl-3-nitrophenyl)ethyl]-N-propylpropan-1-amine hydrochloride

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ethanol; sodium / tetrahydrofuran / 15 - 30 °C / Inert atmosphere
1.2: 25 - 30 °C
2.1: sodium hydroxide; water / toluene; methanol / 0 - 5 °C / pH 12
2.2: 15 °C
2.3: 25 - 70 °C / pH < 2 / Activated charcoal
3.1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 25 - 35 °C / 2059.6 - 3236.52 Torr / Sealed tube
3.2: 0 - 35 °C
View Scheme
4-[2-(benzoyloxy)ethyl]-3-chloro-1,3-dihydro-2H-indolin-2-one
139122-17-1

4-[2-(benzoyloxy)ethyl]-3-chloro-1,3-dihydro-2H-indolin-2-one

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium on activated charcoal; hydrazine hydrate
2: sodium hydroxide; water / Large scale
3: pyridine / Large scale
4: hydrogenchloride / water / Large scale
View Scheme
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux
2: sodium hydroxide; water / methanol / 4 h / Reflux
3: dichloromethane; pyridine / 3 h / 5 - 10 °C
4: water / 5 h / 80 °C
View Scheme
4-(2-chloroethyl)indolin-2-one

4-(2-chloroethyl)indolin-2-one

di-n-propylamine
142-84-7

di-n-propylamine

A

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

B

4-ethylenyl-1,3-dihydro-2H-indol-2-one

4-ethylenyl-1,3-dihydro-2H-indol-2-one

Conditions
ConditionsYield
With hydrogenchloride In water
isochromane
493-05-0

isochromane

A

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

B

4-ethylenyl-1,3-dihydro-2H-indol-2-one

4-ethylenyl-1,3-dihydro-2H-indol-2-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: bromine / water / Irradiation
2: water; methanol / Acidic conditions; Large scale
3: iron(III) chloride / Acidic conditions; Large scale
4: palladium on activated charcoal; sodium hypophosphite monohydrate / water; ethyl acetate / Large scale
5: hydrogenchloride / water / Large scale
View Scheme
1-Bromoisochromane
50683-32-4

1-Bromoisochromane

A

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

B

4-ethylenyl-1,3-dihydro-2H-indol-2-one

4-ethylenyl-1,3-dihydro-2H-indol-2-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: water; methanol / Acidic conditions; Large scale
2: iron(III) chloride / Acidic conditions; Large scale
3: palladium on activated charcoal; sodium hypophosphite monohydrate / water; ethyl acetate / Large scale
4: hydrogenchloride / water / Large scale
View Scheme
C10H10INO

C10H10INO

di-n-propylamine
142-84-7

di-n-propylamine

A

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

B

4-ethylenyl-1,3-dihydro-2H-indol-2-one

4-ethylenyl-1,3-dihydro-2H-indol-2-one

Conditions
ConditionsYield
With hydrogenchloride In water
2-(2-bromoethyl)-β-nitrostyrene

2-(2-bromoethyl)-β-nitrostyrene

A

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

B

4-ethylenyl-1,3-dihydro-2H-indol-2-one

4-ethylenyl-1,3-dihydro-2H-indol-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: iron(III) chloride / Acidic conditions; Large scale
2: palladium on activated charcoal; sodium hypophosphite monohydrate / water; ethyl acetate / Large scale
3: hydrogenchloride / water / Large scale
View Scheme
4-(2-benzoyloxyethyl)-1,3-dihydro-2H-indolin-2-one
139122-18-2

4-(2-benzoyloxyethyl)-1,3-dihydro-2H-indolin-2-one

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; water / Large scale
2: pyridine / Large scale
3: hydrogenchloride / water / Large scale
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide; water / methanol / 4 h / Reflux
2: dichloromethane; pyridine / 3 h / 5 - 10 °C
3: water / 5 h / 80 °C
View Scheme
4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-indolin-2-one
120427-95-4

4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-indolin-2-one

A

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

B

4-ethylenyl-1,3-dihydro-2H-indol-2-one

4-ethylenyl-1,3-dihydro-2H-indol-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium on activated charcoal; sodium hypophosphite monohydrate / water; ethyl acetate / Large scale
2: hydrogenchloride / water / Large scale
View Scheme
benzoic acid (2-(2-nitroethenyl))phenethyl ester
139122-16-0

benzoic acid (2-(2-nitroethenyl))phenethyl ester

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: iron(III) chloride; acetyl chloride / water; dichloromethane / 3 h / 5 °C / Cooling with ice
2: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux
3: sodium hydroxide; water / methanol / 4 h / Reflux
4: dichloromethane; pyridine / 3 h / 5 - 10 °C
5: water / 5 h / 80 °C
View Scheme
2-phenylethanol
60-12-8

2-phenylethanol

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: hydrogenchloride / water / 20 h / 36 °C
2.1: zinc(II) chloride / dichloromethane / Reflux
2.2: 1.5 h / Reflux
3.1: dimethyl sulfoxide; sodium hydrogencarbonate / 3 h / 110 °C
4.1: ammonium acetate / 10 h / Reflux
5.1: iron(III) chloride; acetyl chloride / water; dichloromethane / 3 h / 5 °C / Cooling with ice
6.1: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux
7.1: sodium hydroxide; water / methanol / 4 h / Reflux
8.1: dichloromethane; pyridine / 3 h / 5 - 10 °C
9.1: water / 5 h / 80 °C
View Scheme
isochromane
493-05-0

isochromane

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: zinc(II) chloride / dichloromethane / Reflux
1.2: 1.5 h / Reflux
2.1: dimethyl sulfoxide; sodium hydrogencarbonate / 3 h / 110 °C
3.1: ammonium acetate / 10 h / Reflux
4.1: iron(III) chloride; acetyl chloride / water; dichloromethane / 3 h / 5 °C / Cooling with ice
5.1: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux
6.1: sodium hydroxide; water / methanol / 4 h / Reflux
7.1: dichloromethane; pyridine / 3 h / 5 - 10 °C
8.1: water / 5 h / 80 °C
View Scheme
2-[2-(chloromethyl)phenyl]ethylbenzoate
168476-58-2

2-[2-(chloromethyl)phenyl]ethylbenzoate

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: dimethyl sulfoxide; sodium hydrogencarbonate / 3 h / 110 °C
2: ammonium acetate / 10 h / Reflux
3: iron(III) chloride; acetyl chloride / water; dichloromethane / 3 h / 5 °C / Cooling with ice
4: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux
5: sodium hydroxide; water / methanol / 4 h / Reflux
6: dichloromethane; pyridine / 3 h / 5 - 10 °C
7: water / 5 h / 80 °C
View Scheme
benzoic acid (2-formyl)phenethyl ester
139122-15-9

benzoic acid (2-formyl)phenethyl ester

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: ammonium acetate / 10 h / Reflux
2: iron(III) chloride; acetyl chloride / water; dichloromethane / 3 h / 5 °C / Cooling with ice
3: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux
4: sodium hydroxide; water / methanol / 4 h / Reflux
5: dichloromethane; pyridine / 3 h / 5 - 10 °C
6: water / 5 h / 80 °C
View Scheme
2-(1H-indol-4-yl)acetic acid
16176-74-2

2-(1H-indol-4-yl)acetic acid

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
2: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C
3: 0.01 h / -40 - 80 °C
4: palladium on activated charcoal; hydrogen / 2 h / 20 °C
5: pyridine / 2 h / 20 °C
6: sodium iodide / 4 h / 100 °C
7: hydrogenchloride / 1,4-dioxane; water
View Scheme
C10H11NO

C10H11NO

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C
2: 0.01 h / -40 - 80 °C
3: palladium on activated charcoal; hydrogen / 2 h / 20 °C
4: pyridine / 2 h / 20 °C
5: sodium iodide / 4 h / 100 °C
6: hydrogenchloride / 1,4-dioxane; water
View Scheme
C10H10ClNO

C10H10ClNO

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 0.01 h / -40 - 80 °C
2: palladium on activated charcoal; hydrogen / 2 h / 20 °C
3: pyridine / 2 h / 20 °C
4: sodium iodide / 4 h / 100 °C
5: hydrogenchloride / 1,4-dioxane; water
View Scheme
ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

Ropinirole
91374-21-9

Ropinirole

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.25h;94%
With sodium hydroxide In water for 0.25h;86%
With ammonia; water at 22 - 25℃; for 0.5h; Purification / work up;
formaldehyd
50-00-0

formaldehyd

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

3,3'-methylene ropinirole dimer sulfate

3,3'-methylene ropinirole dimer sulfate

Conditions
ConditionsYield
Stage #1: formaldehyd; ropinirole hydrochloride With N-ethyl-N,N-diisopropylamine In methanol; water at 60℃; for 18h;
Stage #2: With sulfuric acid In methanol; water Reagent/catalyst; Temperature; Solvent;
71%
formaldehyd
50-00-0

formaldehyd

ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

3,3'-methylene ropinirole dimer hydrochloride

3,3'-methylene ropinirole dimer hydrochloride

Conditions
ConditionsYield
Stage #1: formaldehyd; ropinirole hydrochloride With triethylamine In methanol; water at 60℃; for 18h;
Stage #2: With hydrogenchloride In methanol; water Reagent/catalyst; Temperature; Solvent;
69%
ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

2-bromoethyl chloroformate
4801-27-8

2-bromoethyl chloroformate

ropinirole-N-bromoethylcarboxylate
1424879-79-7

ropinirole-N-bromoethylcarboxylate

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 20℃;22.01%
With triethylamine
ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

NBD chloride
10199-89-0

NBD chloride

C22H25N5O4
1036069-92-7

C22H25N5O4

Conditions
ConditionsYield
With borate buffer at 100℃; for 0.5h; pH=8.5;
ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

A

4-(2-dipropylaminoethyl)-1-hydroxy-1,3-dihydroindol-2-one
954117-22-7

4-(2-dipropylaminoethyl)-1-hydroxy-1,3-dihydroindol-2-one

B

4-(2-dipropylaminoethyl)-1H-indol-2,3-dione
102842-51-3

4-(2-dipropylaminoethyl)-1H-indol-2,3-dione

C

2-nitro-6-<2-(di-n-propylamino)ethyl>phenylacetic acid
720656-64-4

2-nitro-6-<2-(di-n-propylamino)ethyl>phenylacetic acid

Conditions
ConditionsYield
With dihydrogen peroxide In dihydrogen peroxide at 80℃; for 5h;
ropinirole hydrochloride
91374-20-8

ropinirole hydrochloride

4-(2-((3-aminopropyl)(propyl)amino)ethyl)indolin-2-one
1632235-97-2

4-(2-((3-aminopropyl)(propyl)amino)ethyl)indolin-2-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water / 0.25 h / 20 °C
2.1: carbonochloridic acid 1-chloro-ethyl ester; sodium hydrogencarbonate / 17 h / 85 °C
2.2: 18 h / Reflux
3.1: sodium hydroxide / water / 0.08 h
4.1: potassium carbonate / acetonitrile / 19 h / Reflux
5.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water / 0.25 h / 20 °C
2.1: carbonochloridic acid 1-chloro-ethyl ester; sodium hydrogencarbonate / 17 h / 85 °C
2.2: 18 h / Reflux
3.1: sodium hydroxide / water / 0.08 h
4.1: potassium carbonate / acetonitrile / 19 h / Reflux
5.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium hydroxide / water / 0.25 h
2: sodium hydrogencarbonate / 17 h / 85 °C
3: sodium hydroxide / water / 1.5 h / 20 °C
4: potassium carbonate / acetonitrile / 19 h / Reflux
5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium hydroxide / water / 0.25 h
2: sodium hydrogencarbonate / 17 h / 85 °C
3: sodium hydroxide / water / 1.5 h / 20 °C
4: potassium carbonate / acetonitrile / 19 h / Reflux
5: potassium carbonate / methanol; 1,4-dioxane / 1 h / 20 °C
View Scheme

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