Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiry1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)- CAS:918516-27-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing i
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquirySuperior quality, moderate price & quick delivery. Appearance:NA Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:It is an important raw material and
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
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inquiryWe produce carbomer by our own factory,carbomer 940 is our best seller.It is used for cosmetic and medical.And we also become agent for lubrizol.Our carbomer 940 get high viscosity and good transparency.The price will depond on the market,surely supp
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiryR & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
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inquiryJ&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
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inquirybest seller Application:API
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate
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inquiryTIANFUCHEM--918516-27-5--1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)- Application:TIANFUCHEM--918516-27-5--1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-
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inquiryAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
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inquirybest seller Application:API
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiry4-Chlorophenylboronic acid
5-bromo-1H-pyrrolo[2,3-b]pyridine
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In Dimethyl ether; water Solvent; Temperature; Reflux; | 92% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,2-dimethoxyethane; water Reflux; | 92% |
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In 1,2-dimethoxyethane at 130℃; for 0.5h; Suzuki coupling; Inert atmosphere; Microwave irradiation; | 76% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
With sodium hydroxide In water; N,N-dimethyl-formamide at 100℃; for 10h; | 81.3% |
5-(4-Cl-phenyl)azaindole
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 20 - 120℃; for 2h; Product distribution / selectivity; | 80% |
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 20 - 120℃; for 2h; |
5-chloro-1H-pyrrolo[2,3-b]pyridine
phenylboronic acid
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; caesium carbonate In water; toluene Inert atmosphere; Reflux; | 75% |
C14H9ClN2O2
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
With quinoline; copper chromite at 220℃; for 0.2h; Microwave irradiation; | 58% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
With quinoline; copper chromite at 220℃; for 0.2h; Microwave irradiation; | 43% |
5-bromo-2-pyridylamine
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C 2: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C 3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere 4: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C 2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C 3: N,N,N',N'-tetramethylguanidine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / toluene / 2 h / 100 °C / Inert atmosphere 4: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 120 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C 2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C 3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C 4: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme |
4-Chlorophenylboronic acid
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C 2: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C 3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere 4: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C 2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C 3: N,N,N',N'-tetramethylguanidine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / toluene / 2 h / 100 °C / Inert atmosphere 4: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 120 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C 2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C 3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C 4: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme |
5-(4-chlorophenyl)pyridin-2-ylamine
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C 2: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere 3: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C 2: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C 3: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C 2: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 24 h / 80 °C 3: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme |
C11H8BrClN2
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C 2: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: N,N,N',N'-tetramethylguanidine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / toluene / 2 h / 100 °C / Inert atmosphere 2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 120 °C View Scheme | |
Multi-step reaction with 2 steps 1: N,N,N',N'-tetramethylguanidine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / toluene / 2 h / 100 °C / Inert atmosphere 2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 120 °C View Scheme | |
Multi-step reaction with 2 steps 1: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C 2: hydrogenchloride / N,N-dimethyl-formamide; water / 1 h / 50 °C View Scheme |
C15H15ClN2O
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
With hydrogenchloride In water at 50℃; for 1h; Product distribution / selectivity; Inert atmosphere; | |
With hydrogenchloride In water; N,N-dimethyl-formamide at 50℃; for 1h; |
C11H8ClIN2
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere 2: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 24 h / 80 °C 2: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere 2: hydrogenchloride / N,N-dimethyl-formamide; water / 1 h / 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 24 h / 80 °C 2: hydrogenchloride / N,N-dimethyl-formamide; water / 1 h / 50 °C View Scheme |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide / water 2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C 3: N,N,N',N'-tetramethylguanidine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / toluene / 2 h / 100 °C / Inert atmosphere 4: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 120 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydroxide / water 2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C 3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C 4: hydrogenchloride / N,N-dimethyl-formamide; water / 1 h / 50 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydroxide / water 2: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C 3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere 4: hydrogenchloride / N,N-dimethyl-formamide; water / 1 h / 50 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydroxide / water 2: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C 3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 24 h / 80 °C 4: hydrogenchloride / N,N-dimethyl-formamide; water / 1 h / 50 °C View Scheme |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium hydroxide / tetrahydrofuran 2: quinoline; copper chromite / 0.2 h / 220 °C / Microwave irradiation View Scheme | |
Multi-step reaction with 3 steps 1: toluene / 0.2 h / 200 °C / Microwave irradiation 2: lithium hydroxide / tetrahydrofuran 3: quinoline; copper chromite / 0.2 h / 220 °C / Microwave irradiation View Scheme |
methyl 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium hydroxide / tetrahydrofuran 2: quinoline; copper chromite / 0.2 h / 220 °C / Microwave irradiation View Scheme |
4-chlorophenylboronic acid pinacol ester
5-bromo-1H-pyrrolo[2,3-b]pyridine
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
With sodium carbonate In water at 120℃; for 0.5h; Irradiation; | 19 mg |
bromochlorobenzene
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium acetate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 0.75 h / 120 °C / Irradiation 2: sodium carbonate / water / 0.5 h / 120 °C / Irradiation View Scheme |
5-bromo-1-(tert-butyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate / toluene; water / 7 h / 85 °C / Inert atmosphere 2: aluminum (III) chloride / chlorobenzene / 100 °C / Inert atmosphere 3: hydrogen bromide; water / 24 h / 100 °C 4: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C View Scheme |
5-(4-chlorophenyl)-1-(tert-butyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aluminum (III) chloride / chlorobenzene / 100 °C / Inert atmosphere 2: hydrogen bromide; water / 24 h / 100 °C 3: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C View Scheme |
4-chlorophenylacetic Acid
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: trichlorophosphate / 8 h / 70 °C 1.2: 2 h / 10 - 26 °C 2.1: sodium methylate / methanol; dimethyl sulfoxide / 1 h / 100 °C / Inert atmosphere 3.1: aluminum (III) chloride / chlorobenzene / 100 °C / Inert atmosphere 4.1: hydrogen bromide; water / 24 h / 100 °C 5.1: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: trichlorophosphate / 2.75 h / 10 - 85 °C / Inert atmosphere 1.2: 1.5 h / 0 - 5 °C 2.1: caesium carbonate / dimethyl sulfoxide / 1.5 h / 80 °C / Inert atmosphere 3.1: aluminum (III) chloride / chlorobenzene / 100 °C / Inert atmosphere 4.1: hydrogen bromide; water / 24 h / 100 °C 5.1: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C View Scheme |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium methylate / methanol; dimethyl sulfoxide / 1 h / 100 °C / Inert atmosphere 2: aluminum (III) chloride / chlorobenzene / 100 °C / Inert atmosphere 3: hydrogen bromide; water / 24 h / 100 °C 4: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C View Scheme |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: caesium carbonate / dimethyl sulfoxide / 1.5 h / 80 °C / Inert atmosphere 2: aluminum (III) chloride / chlorobenzene / 100 °C / Inert atmosphere 3: hydrogen bromide; water / 24 h / 100 °C 4: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C View Scheme |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen bromide; water / 24 h / 100 °C 2: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C View Scheme |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
With sodium hydroxide In water; dimethyl sulfoxide at 113 - 115℃; for 24h; | 31.8 g |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid
Conditions | Yield |
---|---|
Stage #1: 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2.5h; Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine; aluminum (III) chloride In dichloromethane at 20℃; for 3h; | 85% |
Stage #1: 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid With oxalyl dichloride In dichloromethane at 18 - 26℃; for 2h; Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane at 0 - 26℃; for 5h; | 70% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 2-methyl-5-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride | 80% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
benzoyl chloride
C20H13ClN2O
Conditions | Yield |
---|---|
With zirconium(IV) chloride Friedel-Crafts Acylation; | 79% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
2-fluoro-5-(propylsulfonamido)benzoic acid
Conditions | Yield |
---|---|
Stage #1: 2-fluoro-5-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride | 71% |
Stage #1: 2-fluoro-5-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation; Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation; | 71% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
2-fluoro-3-(propylsulfonamido)benzoic acid
Conditions | Yield |
---|---|
Stage #1: 2-fluoro-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride | 68% |
Stage #1: 2-fluoro-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation; Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation; | 68% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide
N-(3-(bis(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-2,4-difluorophenyl)propane-1-sulfonamide
Conditions | Yield |
---|---|
With potassium carbonate In methanol; water at 130℃; for 0.5h; Microwave irradiation; | 64% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
2,6-difluoro-3-(propylsulfonamido)benzoyl chloride
Conditions | Yield |
---|---|
Stage #1: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In 1,2-dichloro-ethane at 0℃; for 0.666667h; Stage #2: 2,6-difluoro-3-(propylsulfonamido)benzoyl chloride In 1,2-dichloro-ethane at 0 - 20℃; | 60% |
With aluminum (III) chloride In dichloromethane at 0 - 20℃; for 3h; |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
2,6-difluoro-3-(2-methylpropylsulfonamido)benzoic acid
Conditions | Yield |
---|---|
Stage #1: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine; 2,6-difluoro-3-(2-methylpropylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Stage #2: With aluminum (III) chloride In dichloromethane | 58% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 3-fluoro-5-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation; Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation; | 55% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 2,6-difluoro-3-(pentylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride | 54% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 2-methyl-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride | 53% |
Stage #1: 2-methyl-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation; Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation; | 53% |
3-(propylsulfonamido)benzoic acid
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation; Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation; | 52% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 2-chloro-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride | 46% |
Stage #1: 2-chloro-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation; Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation; | 46% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
acetyl chloride
Conditions | Yield |
---|---|
Stage #1: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane at 20℃; for 0.5h; Stage #2: acetyl chloride In dichloromethane at 20℃; for 12h; Stage #3: With sodium hydroxide In water pH=5; | 42% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at 20℃; | 38% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Stage #1: C12H13F2NO3 With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane at 20℃; | 38% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 4-fluoro-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation; Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation; | 37% |
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
2,6-difluoro-3-(ethylsulfonamido)benzoic acid
Conditions | Yield |
---|---|
With aluminum (III) chloride; oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane | 29% |
methanol
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide
Conditions | Yield |
---|---|
With potassium hydroxide at 20℃; for 72h; | |
With potassium hydroxide at 20℃; for 72h; |
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