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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

5-(4-CHLOROPHENYL)-1H-PYRROLO[2,3-B]PYRIDINE

Cas:918516-27-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 918516-27-5 with best quality

Cas:918516-27-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)- CAS:918516-27-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing i

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)- CAS:918516-27-5

Cas:918516-27-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

5-(4-CHLOROPHENYL)-1H-PYRROLO[2,3-B]PYRIDINE

Cas:918516-27-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridine

Cas:918516-27-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridine

Cas:918516-27-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

1H-Pyrrolo[2,3-b]pyridine,5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM--918516-27-5--1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFUCHEM--918516-27-5--1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:NA Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:It is an important raw material and

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFUCHEM--918516-27-5--1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

5-(4-chlorophenyl)-1h-pyrrolo(2,3-b)pyridine

Cas:918516-27-5

Min.Order:1 Gram

Negotiable

Type:Other

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridine

Cas:918516-27-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Cas:918516-27-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFUCHEM--918516-27-5--1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

We produce carbomer by our own factory,carbomer 940 is our best seller.It is used for cosmetic and medical.And we also become agent for lubrizol.Our carbomer 940 get high viscosity and good transparency.The price will depond on the market,surely supp

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

TIANFUCHEM--918516-27-5--1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Cas:918516-27-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

TIANFUCHEM--918516-27-5--1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)- Application:TIANFUCHEM--918516-27-5--1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine CAS No.918516-27-5

Cas:918516-27-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

best seller Application:API

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Cas:918516-27-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

5-bromo-1H-pyrrolo[2,3-b]pyridine
183208-35-7

5-bromo-1H-pyrrolo[2,3-b]pyridine

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In Dimethyl ether; water Solvent; Temperature; Reflux;92%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,2-dimethoxyethane; water Reflux;92%
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In 1,2-dimethoxyethane at 130℃; for 0.5h; Suzuki coupling; Inert atmosphere; Microwave irradiation;76%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
With sodium hydroxide In water; N,N-dimethyl-formamide at 100℃; for 10h;81.3%
5-(4-Cl-phenyl)azaindole
1356397-48-2

5-(4-Cl-phenyl)azaindole

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 20 - 120℃; for 2h; Product distribution / selectivity;80%
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 20 - 120℃; for 2h;
5-chloro-1H-pyrrolo[2,3-b]pyridine
866546-07-8

5-chloro-1H-pyrrolo[2,3-b]pyridine

phenylboronic acid
98-80-6

phenylboronic acid

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; caesium carbonate In water; toluene Inert atmosphere; Reflux;75%
C14H9ClN2O2
1431663-20-5

C14H9ClN2O2

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
With quinoline; copper chromite at 220℃; for 0.2h; Microwave irradiation;58%
2-azido-3-(5-(4-chlorophenyl)pyridine-3-yl)acrylic acid

2-azido-3-(5-(4-chlorophenyl)pyridine-3-yl)acrylic acid

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
With quinoline; copper chromite at 220℃; for 0.2h; Microwave irradiation;43%
5-bromo-2-pyridylamine
1072-97-5

5-bromo-2-pyridylamine

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C
2: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C
3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere
4: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C
2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C
3: N,N,N',N'-tetramethylguanidine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / toluene / 2 h / 100 °C / Inert atmosphere
4: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 120 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C
2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C
3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C
4: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere
View Scheme
4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C
2: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C
3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere
4: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C
2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C
3: N,N,N',N'-tetramethylguanidine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / toluene / 2 h / 100 °C / Inert atmosphere
4: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 120 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C
2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C
3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C
4: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere
View Scheme
5-(4-chlorophenyl)pyridin-2-ylamine
84596-08-7

5-(4-chlorophenyl)pyridin-2-ylamine

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C
2: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere
3: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C
2: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C
3: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C
2: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 24 h / 80 °C
3: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere
View Scheme
C11H8BrClN2
911113-60-5

C11H8BrClN2

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C
2: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: N,N,N',N'-tetramethylguanidine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / toluene / 2 h / 100 °C / Inert atmosphere
2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 120 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N,N',N'-tetramethylguanidine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / toluene / 2 h / 100 °C / Inert atmosphere
2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 120 °C
View Scheme
Multi-step reaction with 2 steps
1: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C
2: hydrogenchloride / N,N-dimethyl-formamide; water / 1 h / 50 °C
View Scheme
C15H15ClN2O
1356397-47-1

C15H15ClN2O

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
With hydrogenchloride In water at 50℃; for 1h; Product distribution / selectivity; Inert atmosphere;
With hydrogenchloride In water; N,N-dimethyl-formamide at 50℃; for 1h;
C11H8ClIN2
1356397-46-0

C11H8ClIN2

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere
2: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 24 h / 80 °C
2: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere
2: hydrogenchloride / N,N-dimethyl-formamide; water / 1 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 24 h / 80 °C
2: hydrogenchloride / N,N-dimethyl-formamide; water / 1 h / 50 °C
View Scheme
C11H9ClN2*(x)ClH

C11H9ClN2*(x)ClH

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / water
2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C
3: N,N,N',N'-tetramethylguanidine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / toluene / 2 h / 100 °C / Inert atmosphere
4: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 120 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide / water
2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C
3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C
4: hydrogenchloride / N,N-dimethyl-formamide; water / 1 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide / water
2: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C
3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere
4: hydrogenchloride / N,N-dimethyl-formamide; water / 1 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide / water
2: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C
3: lithium hydroxide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 24 h / 80 °C
4: hydrogenchloride / N,N-dimethyl-formamide; water / 1 h / 50 °C
View Scheme
C15H11ClN4O2

C15H11ClN4O2

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hydroxide / tetrahydrofuran
2: quinoline; copper chromite / 0.2 h / 220 °C / Microwave irradiation
View Scheme
Multi-step reaction with 3 steps
1: toluene / 0.2 h / 200 °C / Microwave irradiation
2: lithium hydroxide / tetrahydrofuran
3: quinoline; copper chromite / 0.2 h / 220 °C / Microwave irradiation
View Scheme
methyl 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
1426575-26-9

methyl 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hydroxide / tetrahydrofuran
2: quinoline; copper chromite / 0.2 h / 220 °C / Microwave irradiation
View Scheme
4-chlorophenylboronic acid pinacol ester
195062-61-4

4-chlorophenylboronic acid pinacol ester

5-bromo-1H-pyrrolo[2,3-b]pyridine
183208-35-7

5-bromo-1H-pyrrolo[2,3-b]pyridine

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
With sodium carbonate In water at 120℃; for 0.5h; Irradiation;19 mg
bromochlorobenzene
106-39-8

bromochlorobenzene

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium acetate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 0.75 h / 120 °C / Irradiation
2: sodium carbonate / water / 0.5 h / 120 °C / Irradiation
View Scheme
5-bromo-1-(tert-butyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
1372929-27-5

5-bromo-1-(tert-butyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate / toluene; water / 7 h / 85 °C / Inert atmosphere
2: aluminum (III) chloride / chlorobenzene / 100 °C / Inert atmosphere
3: hydrogen bromide; water / 24 h / 100 °C
4: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C
View Scheme
5-(4-chlorophenyl)-1-(tert-butyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
1418299-52-1

5-(4-chlorophenyl)-1-(tert-butyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aluminum (III) chloride / chlorobenzene / 100 °C / Inert atmosphere
2: hydrogen bromide; water / 24 h / 100 °C
3: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C
View Scheme
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trichlorophosphate / 8 h / 70 °C
1.2: 2 h / 10 - 26 °C
2.1: sodium methylate / methanol; dimethyl sulfoxide / 1 h / 100 °C / Inert atmosphere
3.1: aluminum (III) chloride / chlorobenzene / 100 °C / Inert atmosphere
4.1: hydrogen bromide; water / 24 h / 100 °C
5.1: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C
View Scheme
Multi-step reaction with 5 steps
1.1: trichlorophosphate / 2.75 h / 10 - 85 °C / Inert atmosphere
1.2: 1.5 h / 0 - 5 °C
2.1: caesium carbonate / dimethyl sulfoxide / 1.5 h / 80 °C / Inert atmosphere
3.1: aluminum (III) chloride / chlorobenzene / 100 °C / Inert atmosphere
4.1: hydrogen bromide; water / 24 h / 100 °C
5.1: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C
View Scheme
N-(2-(4-chlorophenyl)-3-(dimethylamino)allylidene)-N-methylmethanaminium hexafluorophosphate

N-(2-(4-chlorophenyl)-3-(dimethylamino)allylidene)-N-methylmethanaminium hexafluorophosphate

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium methylate / methanol; dimethyl sulfoxide / 1 h / 100 °C / Inert atmosphere
2: aluminum (III) chloride / chlorobenzene / 100 °C / Inert atmosphere
3: hydrogen bromide; water / 24 h / 100 °C
4: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C
View Scheme
N-(2-(4-chlorophenyl)-3-(dimethylamino)allylidene)-N-methylmethanaminium tetrafluoroborate

N-(2-(4-chlorophenyl)-3-(dimethylamino)allylidene)-N-methylmethanaminium tetrafluoroborate

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: caesium carbonate / dimethyl sulfoxide / 1.5 h / 80 °C / Inert atmosphere
2: aluminum (III) chloride / chlorobenzene / 100 °C / Inert atmosphere
3: hydrogen bromide; water / 24 h / 100 °C
4: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C
View Scheme
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen bromide; water / 24 h / 100 °C
2: sodium hydroxide / water; dimethyl sulfoxide / 24 h / 113 - 115 °C
View Scheme
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid hydrobromide

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid hydrobromide

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
With sodium hydroxide In water; dimethyl sulfoxide at 113 - 115℃; for 24h;31.8 g
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid
1103234-56-5

2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid

vemurafenib

vemurafenib

Conditions
ConditionsYield
Stage #1: 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2.5h;
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine; aluminum (III) chloride In dichloromethane at 20℃; for 3h;
85%
Stage #1: 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid With oxalyl dichloride In dichloromethane at 18 - 26℃; for 2h;
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane at 0 - 26℃; for 5h;
70%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

2-methyl-5-(propylsulfonamido)benzoic acid

2-methyl-5-(propylsulfonamido)benzoic acid

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-4-methylphenyl)propane-1-sulfonamide

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-4-methylphenyl)propane-1-sulfonamide

Conditions
ConditionsYield
Stage #1: 2-methyl-5-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride
80%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

benzoyl chloride
98-88-4

benzoyl chloride

C20H13ClN2O
1426575-27-0

C20H13ClN2O

Conditions
ConditionsYield
With zirconium(IV) chloride Friedel-Crafts Acylation;79%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

2-fluoro-5-(propylsulfonamido)benzoic acid
918524-58-0

2-fluoro-5-(propylsulfonamido)benzoic acid

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-4-fluorophenyl)propane-1-sulfonamide

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-4-fluorophenyl)propane-1-sulfonamide

Conditions
ConditionsYield
Stage #1: 2-fluoro-5-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride
71%
Stage #1: 2-fluoro-5-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation;
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation;
71%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

2-fluoro-3-(propylsulfonamido)benzoic acid
918523-49-6

2-fluoro-3-(propylsulfonamido)benzoic acid

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluorophenyl)propane-1-sulfonamide

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluorophenyl)propane-1-sulfonamide

Conditions
ConditionsYield
Stage #1: 2-fluoro-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride
68%
Stage #1: 2-fluoro-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation;
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation;
68%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide
918523-58-7

N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide

N-(3-(bis(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-2,4-difluorophenyl)propane-1-sulfonamide
1522361-91-6

N-(3-(bis(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-2,4-difluorophenyl)propane-1-sulfonamide

Conditions
ConditionsYield
With potassium carbonate In methanol; water at 130℃; for 0.5h; Microwave irradiation;64%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

2,6-difluoro-3-(propylsulfonamido)benzoyl chloride
1186194-32-0

2,6-difluoro-3-(propylsulfonamido)benzoyl chloride

vemurafenib

vemurafenib

Conditions
ConditionsYield
Stage #1: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In 1,2-dichloro-ethane at 0℃; for 0.666667h;
Stage #2: 2,6-difluoro-3-(propylsulfonamido)benzoyl chloride In 1,2-dichloro-ethane at 0 - 20℃;
60%
With aluminum (III) chloride In dichloromethane at 0 - 20℃; for 3h;
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

2,6-difluoro-3-(2-methylpropylsulfonamido)benzoic acid
1186194-09-1

2,6-difluoro-3-(2-methylpropylsulfonamido)benzoic acid

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-2-methylpropane-1-sulfonamide

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-2-methylpropane-1-sulfonamide

Conditions
ConditionsYield
Stage #1: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine; 2,6-difluoro-3-(2-methylpropylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane
Stage #2: With aluminum (III) chloride In dichloromethane
58%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

3-fluoro-5-(propylsulfonamido)benzoic acid

3-fluoro-5-(propylsulfonamido)benzoic acid

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-5-fluorophenyl)propane-1-sulfonamide

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-5-fluorophenyl)propane-1-sulfonamide

Conditions
ConditionsYield
Stage #1: 3-fluoro-5-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation;
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation;
55%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

2,6-difluoro-3-(pentylsulfonamido)benzoic acid

2,6-difluoro-3-(pentylsulfonamido)benzoic acid

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)pentane-1-sulfonamide

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)pentane-1-sulfonamide

Conditions
ConditionsYield
Stage #1: 2,6-difluoro-3-(pentylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride
54%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

2-methyl-3-(propylsulfonamido)benzoic acid

2-methyl-3-(propylsulfonamido)benzoic acid

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-methylphenyl)propane-1-sulfonamide

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-methylphenyl)propane-1-sulfonamide

Conditions
ConditionsYield
Stage #1: 2-methyl-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride
53%
Stage #1: 2-methyl-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation;
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation;
53%
3-(propylsulfonamido)benzoic acid
849409-82-1

3-(propylsulfonamido)benzoic acid

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-propane-1-sulfonamide

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-propane-1-sulfonamide

Conditions
ConditionsYield
Stage #1: 3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation;
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation;
52%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

2-chloro-3-(propylsulfonamido)benzoic acid

2-chloro-3-(propylsulfonamido)benzoic acid

N-(2-chloro-3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide

N-(2-chloro-3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide

Conditions
ConditionsYield
Stage #1: 2-chloro-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride
46%
Stage #1: 2-chloro-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation;
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation;
46%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

acetyl chloride
75-36-5

acetyl chloride

1-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone

1-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone

Conditions
ConditionsYield
Stage #1: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane at 20℃; for 0.5h;
Stage #2: acetyl chloride In dichloromethane at 20℃; for 12h;
Stage #3: With sodium hydroxide In water pH=5;
42%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

C10H11BrClNO3S

C10H11BrClNO3S

N-(3-bromo-5-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide

N-(3-bromo-5-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 20℃;38%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

C12H13F2NO3

C12H13F2NO3

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)butyramide

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)butyramide

Conditions
ConditionsYield
Stage #1: C12H13F2NO3 With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃;
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane at 20℃;
38%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

4-fluoro-3-(propylsulfonamido)benzoic acid

4-fluoro-3-(propylsulfonamido)benzoic acid

N-(5-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluorophenyl)propane-1-sulfonamide

N-(5-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluorophenyl)propane-1-sulfonamide

Conditions
ConditionsYield
Stage #1: 4-fluoro-3-(propylsulfonamido)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane Friedel-Crafts Acylation;
Stage #2: 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation;
37%
5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

2,6-difluoro-3-(ethylsulfonamido)benzoic acid
1186609-71-1

2,6-difluoro-3-(ethylsulfonamido)benzoic acid

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)ethanesulfonamide

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)ethanesulfonamide

Conditions
ConditionsYield
With aluminum (III) chloride; oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane29%
methanol
67-56-1

methanol

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
918516-27-5

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide
918523-58-7

N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide

A

propane-1-sulfonic acid (3-{[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-methoxy-methyl}-2,4-difluoro-phenyl)-amide

propane-1-sulfonic acid (3-{[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-methoxy-methyl}-2,4-difluoro-phenyl)-amide

B

propane-1-sulfonic acid (3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-yl]hydroxymethyl}-2,4-difluorophenyl)amide

propane-1-sulfonic acid (3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-yl]hydroxymethyl}-2,4-difluorophenyl)amide

Conditions
ConditionsYield
With potassium hydroxide at 20℃; for 72h;
With potassium hydroxide at 20℃; for 72h;

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